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https://www.readbyqxmd.com/read/29054106/age-of-diagnosis-incidence-and-prevalence-of-recurrent-respiratory-papillomatosis-a-south-african-perspective
#1
R Y Seedat, R Schall
OBJECTIVES: To determine the distribution of the age of onset of recurrent respiratory papillomatosis (RRP) and to determine the incidence and prevalence of RRP in both adults and children in the Free State province of South Africa in order to provide data from a population in sub-Saharan African. DESIGN: Retrospective record review. PARTICIPANTS: All patients with recurrent respiratory papillomatosis in the Free State province of South Africa between 2011 and 2015...
October 20, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/29054048/synthesis-and-characterization-of-incorporating-mussel-mimetic-moieties-into-photoactive-hydrogel-adhesive
#2
Zhiwen Zeng, Hongsheng Wang, Yosry Morsi, Xiumei Mo
Surgical adhesive is the optimal candidate for the replacement of traditional mechanical wound closure. In our paper, mussel adhesive proteins inspired hydrogel adhesive was prepared with 3, 4-dihydroxyphyenylanine acrylamide (DOPA-AA), poly (ethylene glycol) diacrylate (PEGDAA) and thiolated chitosan (CSS) by UV irradiation. DOPA-AA, containing catechol group and vinyl group, was successful synthesized and characterized by FTIR and (1)HNMR. The gelation time, equilibrium water content, degradation, materials properties and adhesive strength of the hydrogels were studied...
October 14, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29053901/familial-hypercholesterolaemia-in-patients-with-ischemic-stroke-or-transient-ischemic-attack
#3
Thomas Toell, Lukas Mayer, Raimund Pechlaner, Stefan Krebs, Karin Willeit, Clemens Lang, Christian Boehme, Barbara Prantl, Michael Knoflach, Julia Ferrari, Philipp Fuchs, Wolfgang Prokop, Andrea Griesmacher, Wilfried Lang, Stefan Kiechl, Johann Willeit
BACKGROUND AND AIMS: Identification of patients with familial hypercholesterolemia (FH) is a prerequisite for the appropriate management of their excess cardiovascular risk. It is currently unknown how many patients with acute ischemic stroke or transient ischemic attack (TIA) are affected by FH and whether systematic screening for FH is warranted in these patients. METHODS: The prevalence of a clinical diagnosis of FH was estimated in a large representative series of patients with acute ischemic stroke or TIA (ABCD2 score ≥3) using the Dutch Lipid Clinic Network Algorithm (DLCNA; possible FH ≥3, probable/definite FH ≥6)...
October 20, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29053890/prospective-comparison-of-aman-and-aidp-in-140-children-with-guillain-barr%C3%A3-syndrome-in-india
#4
Jayantee Kalita, Mritunjai Kumar, Usha K Misra
Introduction There is paucity of reports on subtypes of Guillain-Barré syndrome (GBS) in children. We compared clinical and laboratory findings of acute inflammatory demyelinating poly-radiculo-neuropathy (AIDP) and acute motor axonal neuropathy (AMAN). Methods 140 children with GBS were included. Based on nerve conduction study (NCS), patients were sub-classified as AIDP, AMAN, acute motor sensory axonal neuropathy (AMSAN), and equivocal. Results Clinically 72.1% of patients had pure motor, 24.3% motor-sensory and 3...
October 20, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/29053885/cortical-superficial-siderosis-and-acute-convexity-subarachnoid-hemorrhage-in-cerebral-amyloid-angiopathy
#5
Nicolas Raposo, Lionel Calviere, Vanessa Cazzola, Mélanie Planton, Sofia Patsoura, Matthieu Wargny, Jean François Albucher, Agnès Sommet, Jean Marc Olivot, François Chollet, Jérémie Pariente, Fabrice Bonneville, Alain Viguier
BACKGROUND: Acute convexity subarachnoid hemorrhage (cSAH) and cortical superficial siderosis (cSS) are neuroimaging markers of cerebral amyloid angiopathy (CAA) that may arise through similar mechanisms. We sought to compare the prevalence of cSS between patients with CAA presenting with acute cSAH versus lobar intracerebral hemorrhage (ICH), and to explore the physiopathology of cSS by examining neuroimaging associations. METHODS: We retrospectively analyzed data from 116 consecutive patients with probable CAA (mean age, 77...
October 20, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29053874/tau-pathology-and-neurodegeneration-contribute-to-cognitive-impairment-in-alzheimer-s-disease
#6
Alexandre Bejanin, Daniel R Schonhaut, Renaud La Joie, Joel H Kramer, Suzanne L Baker, Natasha Sosa, Nagehan Ayakta, Averill Cantwell, Mustafa Janabi, Mariella Lauriola, James P O'Neil, Maria L Gorno-Tempini, Zachary A Miller, Howard J Rosen, Bruce L Miller, William J Jagust, Gil D Rabinovici
Neuropathological and in vivo studies have revealed a tight relationship between tau pathology and cognitive impairment across the Alzheimer's disease spectrum. However, tau pathology is also intimately associated with neurodegeneration and amyloid pathology. The aim of the present study was therefore to assess whether grey matter atrophy and amyloid pathology contribute to the relationship between tau pathology, as measured with 18F-AV-1451-PET imaging, and cognitive deficits in Alzheimer's disease. We included 40 amyloid-positive patients meeting criteria for mild cognitive impairment due to Alzheimer's disease (n = 5) or probable Alzheimer's disease dementia (n = 35)...
October 7, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29053865/beta-burst-dynamics-in-parkinson-s-disease-off-and-on-dopaminergic-medication
#7
Gerd Tinkhauser, Alek Pogosyan, Huiling Tan, Damian M Herz, Andrea A Kühn, Peter Brown
Exaggerated basal ganglia beta activity (13-35 Hz) is commonly found in patients with Parkinson's disease and can be suppressed by dopaminergic medication, with the degree of suppression being correlated with the improvement in motor symptoms. Importantly, beta activity is not continuously elevated, but fluctuates to give beta bursts. The percentage number of longer beta bursts in a given interval is positively correlated with clinical impairment in Parkinson's disease patients. Here we determine whether the characteristics of beta bursts are dependent on dopaminergic state...
October 10, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29053844/evolutionally-conserved-function-of-kisspeptin-neuronal-system-is-non-reproductive-regulation-as-revealed-by-non-mammalian-study
#8
Mikoto Nakajo, Shinji Kanda, Tomomi Karigo, Akiko Takahashi, Yasuhisa Akazome, Yoshihisa Uenoyama, Makito Kobayashi, Yoshitaka Oka
Kisspeptin neuronal system, which consists of a neuropeptide kisspeptin and its receptor Gpr54, is considered in mammals a key factor of reproductive regulation, so called hypothalamic-pituitary-gonadal (HPG) axis. However, in non-mammalian vertebrates, especially in teleosts, existence of kisspeptin regulation on HPG axis is still controversial. Here, we applied multidisciplinary techniques to a teleost fish, medaka and examined possible kisspeptin regulation on HPG axis. First, we generated knockout medaka for kisspeptin-related genes and found that they show normal fertility, gonadal maturation, and expression of gonadotropins...
October 18, 2017: Endocrinology
https://www.readbyqxmd.com/read/29053768/investigating-the-impact-of-maternal-residential-mobility-on-identifying-critical-windows-of-susceptibility-to-ambient-air-pollution-during-pregnancy
#9
Joshua L Warren, Ji-Young Son, Gavin Pereira, Brian P Leaderer, Michelle L Bell
Identifying periods of increased vulnerability during pregnancy to air pollution with respect to the development of adverse birth outcomes can improve understanding of possible mechanisms of disease development and provide guidelines for protection of the child. Exposure to air pollution during pregnancy is typically based on the residence at delivery, potentially resulting in exposure misclassification and biasing the estimation of critical windows. In this work, we determine the impact of maternal residential mobility during pregnancy on defining weekly exposure to PM10 and the estimation of windows of susceptibility for term low birth weight utilizing birth cohort datasets from Connecticut (1988-2008) that include information on all residential addresses for each woman between conception and delivery...
October 19, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/29053746/external-auditory-exostoses-and-hearing-loss-in-the-shanidar-1-neandertal
#10
Erik Trinkaus, Sébastien Villotte
The Late Pleistocene Shanidar 1 older adult male Neandertal is known for the crushing fracture of his left orbit with a probable reduction in vision, the loss of his right forearm and hand, and evidence of an abnormal gait, as well as probable diffuse idiopathic skeletal hyperostosis. He also exhibits advanced external auditory exostoses in his left auditory meatus and larger ones with complete bridging across the porus in the right meatus (both Grade 3). These growths indicate at least unilateral conductive hearing (CHL) loss, a serious sensory deprivation for a Pleistocene hunter-gatherer...
2017: PloS One
https://www.readbyqxmd.com/read/29053607/does-migration-limit-the-effect-of-health-insurance-on-hypertension-management-in-china
#11
Hai Fang, Yinzi Jin, Miaomiao Zhao, Huyang Zhang, John A Rizzo, Donglan Zhang, Zhiyuan Hou
Background: In China, rapid urbanization has caused migration from rural to urban areas, and raised the prevalence of hypertension. However, public health insurance is not portable from one place to another, and migration may limit the effectiveness of this non-portable health insurance on healthcare. Our study aims to investigate whether migration limits the effectiveness of health insurance on hypertension management in China. Methods: Data were obtained from the national baseline survey of the China Health and Retirement Longitudinal Study in 2011, including 4926 hypertensive respondents with public health insurance...
October 20, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29053578/treatment-with-synthetic-glucocorticoids-and-the-hypothalamus-pituitary-adrenal-axis
#12
REVIEW
Rosa Maria Paragliola, Giampaolo Papi, Alfredo Pontecorvi, Salvatore Maria Corsello
Chronic glucocorticoid (GC) treatment represents a widely-prescribed therapy for several diseases in consideration of both anti-inflammatory and immunosuppressive activity but, if used at high doses for prolonged periods, it can determine the systemic effects characteristic of Cushing's syndrome. In addition to signs and symptoms of hypercortisolism, patients on chronic GC therapy are at risk to develop tertiary adrenal insufficiency after the reduction or the withdrawal of corticosteroids or during acute stress...
October 20, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29053399/new-pathogenic-variant-in-the-fgf10-gene-in-the-agenesis-of-lacrimal-and-salivary-gland-syndrome-ophthalmological-and-genetic-study
#13
Maria Jesus Rodrigo, Miriam Idoipe, Silvia Izquierdo, Maria Satue, Antonio Mateo, Antonio Sanchez, Elena Garcia-Martin, Luis Pablo
Aplasia/agenesis of lacrimal and salivary glands is a rare congenital defect that has been associated with disturbances in fibroblast growth factor 10 (FGF10). It can present with symptoms of congenital lacrimal obstruction, dry eye, and dry mouth. We report the ophthalmological and genetic study of a 19-year-old woman and her relatives suffering from this syndrome. A new probably pathogenic variant is described in the FGF10 gene.
October 20, 2017: Ophthalmic Genetics
https://www.readbyqxmd.com/read/29053337/obesity-and-severity-of-acute-exacerbation-of-chronic-obstructive-pulmonary-disease
#14
Tadahiro Goto, Atsushi Hirayama, Mohammad Kamal Faridi, Carlos A Camargo, Kohei Hasegawa
RATIONALE: Obesity is relatively common among individuals with chronic obstructive pulmonary disease (COPD). However, little is known about the association of obesity with severity of acute exacerbation of COPD (AECOPD) and in-hospital mortality. OBJECTIVES: To examine the association of obesity with severity markers of AECOPD and in-hospital mortality. METHODS: This is a retrospective cohort study using population-based data - the 2012-2013 State Inpatient Databases - of seven US states (Arkansas, Florida, Iowa, Nebraska, New York, Utah, and Washington)...
October 20, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/29053327/exact-identification-of-a-quantum-change-point
#15
Gael Sentís, John Calsamiglia, Ramon Muñoz-Tapia
The detection of change points is a pivotal task in statistical analysis. In the quantum realm, it is a new primitive where one aims at identifying the point where a source that supposedly prepares a sequence of particles in identical quantum states starts preparing a mutated one. We obtain the optimal procedure to identify the change point with certainty-naturally at the price of having a certain probability of getting an inconclusive answer. We obtain the analytical form of the optimal probability of successful identification for any length of the particle sequence...
October 6, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29053317/supercoiling-dna-locates-mismatches
#16
Andrew Dittmore, Sumitabha Brahmachari, Yasuharu Takagi, John F Marko, Keir C Neuman
We present a method of detecting sequence defects by supercoiling DNA with magnetic tweezers. The method is sensitive to a single mismatched base pair in a DNA sequence of several thousand base pairs. We systematically compare DNA molecules with 0 to 16 adjacent mismatches at 1 M monovalent salt and 3.6 pN force and show that under these conditions, a single plectoneme forms and is stably pinned at the defect. We use these measurements to estimate the energy and degree of end-loop kinking at defects. From this, we calculate the relative probability of plectoneme pinning at the mismatch under physiologically relevant conditions...
October 6, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29053283/localization-transition-induced-by-learning-in-random-searches
#17
Andrea Falcón-Cortés, Denis Boyer, Luca Giuggioli, Satya N Majumdar
We solve an adaptive search model where a random walker or Lévy flight stochastically resets to previously visited sites on a d-dimensional lattice containing one trapping site. Because of reinforcement, a phase transition occurs when the resetting rate crosses a threshold above which nondiffusive stationary states emerge, localized around the inhomogeneity. The threshold depends on the trapping strength and on the walker's return probability in the memoryless case. The transition belongs to the same class as the self-consistent theory of Anderson localization...
October 6, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29053246/driving-chemical-reactions-in-plasmonic-nanogaps-with-electrohydrodynamic-flow
#18
William John Thrift, Cuong Quoc Nguyen, Mahsa Darvishzadeh-Varcheie, Siavash Zare, Nicholas Sharac, Robert Noboru Sanderson, Torin J Dupper, Allon I Hochbaum, Filippo Capolino, Mohammad Javad Abdolhosseini Qomi, Regina Ragan
Nanoparticles from colloidal solution - with controlled composition, size, and shape - serve as excellent building blocks for plasmonic devices and metasurfaces. However, understanding hierarchical driving forces affecting geometry of oligomers and interparticle gap spacings is still needed to fabricate high density architectures over large areas. Here, electrohydrodynamic (EHD) flow is used as a long-range driving force to enable carbodiimide crosslinking between nanospheres and produces oligomers exhibiting sub-nanometer gap spacing over mm(2) areas...
October 20, 2017: ACS Nano
https://www.readbyqxmd.com/read/29053204/xen-45-collagen-implant-for-the-treatment-of-uveitic-glaucoma
#19
Chelvin Ca Sng, Jing Wang, Scott Hau, Hla Myint Htoon, Keith Barton
IMPORTANCE: The XEN-45 implant, a hydrophilic collagen implant which drains aqueous to the subconjunctival space, has not been investigated in the context of uveitic glaucoma. BACKGROUND: To determine the safety and efficacy of the XEN-45 collagen implant in eyes with uveitic glaucoma. DESIGN: Exploratory prospective case series PARTICIPANTS: Patients with medically uncontrolled uveitic glaucoma METHODS: Twenty four consecutive patients (mean age ± standard deviation [SD] = 45...
October 20, 2017: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/29053183/impact-of-recent-medicaid-expansions-on-office-based-primary-care-and-specialty-care-among-the-newly-eligible
#20
Adam I Biener, Samuel H Zuvekas, Steven C Hill
OBJECTIVE: To quantify the effect of Medicaid expansions on office-based care among the newly eligible. DATA SOURCE: 2008-2014 Medical Expenditure Panel Survey. STUDY DESIGN: The main sample is adults age 26-64 with incomes ≤138% of poverty who were not eligible for Medicaid prior to the Affordable Care Act. For this population, difference-in-differences linear probability models compare utilization between expansion and nonexpansion states and between 2008-2013 and 2014...
October 20, 2017: Health Services Research
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