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Hypercholesterolaemia

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https://www.readbyqxmd.com/read/29351744/risk-factors-for-first-time-acute-myocardial-infarction-patients-in-trinidad
#1
M Bahall, T Seemungal, G Legall
BACKGROUND: The relative importance of coronary artery disease (CAD) risk varies globally. The aim of this study was to determine CAD risk factors for acute myocardial infarction (AMI) among patients in public health care institutions in Trinidad using a case-control type study design. METHODS: The sample comprised 251 AMI patients hospitalized between March 1, 2011 and April 30, 2012 and 464 age- and sex-matched non-AMI patients with no terminal or life-threatening illness and who did not undergo treatment for CAD...
January 19, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29338565/associations-of-the-lipid-genetic-variants-thr54-fabp2-and-493t-mttp-with-total-cholesterol-and-low-density-lipoprotein-cholesterol-levels-in-mexican-subjects
#2
Karina Gonzalez-Becerra, Omar Ramos-Lopez, Mary Lolis Garcia-Cazarin, Elisa Barron-Cabrera, Arturo Panduro, Erika Martinez-Lopez
Objective Mexico has one of the world's highest rates of obesity, which is influenced by lipid-genetic and lifestyle factors. This study aimed to determine whether FABP2 (Ala54Thr) and MTTP (-493 G/T) genetic polymorphisms are associated with metabolic disorders in Mexican subjects. Methods A total of 523 subjects participated in a cross-sectional study. Genotyping for FABP2 and MTTP was performed using real-time RT-PCR. Biochemical and anthropometric data were evaluated. Results The genetically at-risk group (Thr54/-493T) was associated with significantly higher total and low-density lipoprotein cholesterol levels (difference between genetically at-risk group and wild-type group: 10...
January 1, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29332377/comparisons-of-three-different-doses-of-alirocumab-application-in-patients-with-hypercholesterolaemia-a-meta-analysis
#3
Yu-Sheng Zhang, Ye-Hua Hao, Hou-Long Luo, Bao-Cheng Xie, Jian-Ying Fu, Zhi-Kun Zhou
INTRODUCTION: Low high-density lipoprotein cholesterol (HDL-C) and high low-density lipoprotein cholesterol (LDL-C) levels are associated with incidence of cardiovascular disease (CVD). Alirocumab has been considered as an efficacious, safe and promising therapeutic modality for hypercholesterolemia. The purpose of this study is to compare the differences of the three different doses of alirocumab in patients with hypercholesterolaemia. EVIDENCE ACQUISITION: Randomized controlled trials were identified from PubMed, EMBASE, PMC and Cochrane-library databases...
January 11, 2018: Minerva Medica
https://www.readbyqxmd.com/read/29306853/management-of-homozygous-familial-hypercholesterolaemia-in-two-brothers
#4
José Real, Cristina Arbona, Rosa Goterris, Juan Francisco Ascaso
Homozygous familial hypercholesterolaemia (HoFH) is a rare, genetic disorder of abnormally high levels of low-density lipoprotein cholesterol (LDL-C) requiring aggressive interventions to retard the evolution of atherosclerotic cardiovascular disease. We treated two brothers (ages 46 years and 47 years) with HoFH with statins, lipoproteinapheresis (LA) and the microsomal triglyceride transfer protein inhibitor lomitapide. Both brothers carried the p.Thr434Arg homozygous LDLR mutation and had childhood total cholesterol levels >700 mg/dL...
January 6, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29275346/clinical-features-and-prognosis-of-patients-with-acute-non-specific-chest-pain-in-emergency-and-cardiology-departments-after-the-introduction-of-high-sensitivity-troponins-a-prospective-cohort-study
#5
Nivethitha Ilangkovan, Hans Mickley, Axel Diederichsen, Annmarie Lassen, Thomas L Sørensen, Hussam Mahmoud Sheta, Peter B Stæhr, Christian Backer Mogensen
OBJECTIVES: To determine the incidence of clinical, cardiac-related endpoints and mortality among patients presenting to an emergency or cardiology department with non-specific chest pain (NSCP), and who receive testing with a high-sensitivity troponin. A second objective was to identify risk factors for the above-noted endpoints during 12 months of follow-up. DESIGN: A prospective multicentre study. SETTING: Emergency and cardiology departments in Southern Denmark...
December 22, 2017: BMJ Open
https://www.readbyqxmd.com/read/29219151/familial-hypercholesterolaemia
#6
REVIEW
Joep C Defesche, Samuel S Gidding, Mariko Harada-Shiba, Robert A Hegele, Raul D Santos, Anthony S Wierzbicki
Familial hypercholesterolaemia is a common inherited disorder characterized by abnormally elevated serum levels of low-density lipoprotein (LDL) cholesterol from birth, which in time can lead to cardiovascular disease (CVD). Most cases are caused by autosomal dominant mutations in LDLR, which encodes the LDL receptor, although mutations in other genes coding for proteins involved in cholesterol metabolism or LDLR function and processing, such as APOB and PCSK9, can also be causative, although less frequently...
December 7, 2017: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/29219145/familial-hypercholesterolaemia
#7
REVIEW
(no author information available yet)
No abstract text is available yet for this article.
December 7, 2017: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/29208363/the-uk-paediatric-familial-hypercholesterolaemia-register-statin-related-safety-and-1-year-growth-data
#8
Steve E Humphries, Jackie Cooper, Peter Dale, Uma Ramaswami
BACKGROUND: For children with familial hypercholesterolemia (FH), UK guidelines recommend consideration of statin therapy by age 10 years and dietary and lifestyle advice to maintain an ideal body weight. OBJECTIVES: The objective of the study is to use the UK Paediatric Familial Hypercholesterolemia Register to determine: (1) the prevalence of plasma markers of liver toxicity and muscle damage in statin-treated FH children; (2) the prevalence of obesity in FH children compared to the UK general population; and (3) to compare growth rates in statin-treated and nontreated children...
November 22, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/29206916/regulation-of-low-density-lipoprotein-cholesterol-by-intestinal-inflammation-and-the-acute-phase-response
#9
Karl Herbert, Clett Erridge
Systemic inflammation, induced by disease or experimental intervention, is well established to result in elevated levels of circulating triglycerides, and reduced levels of high-density lipoprotein-cholesterol (HDL-C), in most mammalian species. However, the relationship between inflammation and low-density lipoprotein-cholesterol (LDL-C) concentrations is less clear. Most reports indicate that systemic inflammation, as observed during sepsis or following high dose experimental endotoxaemia, lowers total and LDL-C in man...
November 30, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/29193500/stroke-patients-with-familial-hypercholesterolemia-need-for-detection-and-aggressive-treatment
#10
Haralampos Milionis
Familial hypercholesterolaemia (FH) is an autosomal dominant disorder originating from mutations in genes encoding low density lipoprotein (LDL)-receptor, apolipoprotein B (apoB), or proprotein convertase subtilisin/kexin type 9 (PCSK9), thus resulting in severe elevations of total and LDL cholesterol levels. Heterozygous FH (HeFH) occurs in 1 in 250 people, whereas homozygous FH (HoFH) is very rare, occurring in about 1 in 160,000 to one million people worldwide [1]. Despite the fact that FH is a relatively rare disease, it is of profound medical interest by serving as a model disease for atherosclerosis...
November 28, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29181714/discontinuation-of-efavirenz-in-paediatric-patients-why-do-children-switch
#11
Elke Wynberg, Eleri Williams, Gareth Tudor-Williams, Hermione Lyall, Caroline Foster
BACKGROUND: Efavirenz, a non-nucleoside reverse transcriptase inhibitor (NNRTI) is used globally as first-line antiretroviral therapy (ART) in combination with a dual nucleoside backbone in adults and children from 3 years of age. Up to 40% of adults taking efavirenz report central nervous system (CNS) adverse effects, and the rates of discontinuation of efavirenz-based treatment are higher than other first-line regimens. Data on efavirenz discontinuation are more limited for children and adolescents...
November 27, 2017: Clinical Drug Investigation
https://www.readbyqxmd.com/read/29154680/cardiovascular-disease-predictors-and-adipose-tissue-macrophage-polarization-is-there-a-link
#12
Ivana Kralova Lesna, Marek Petras, Sona Cejkova, Anna Kralova, Jiri Fronek, Libor Janousek, Filip Thieme, Tomas Tyll, Rudolf Poledne
Background The risk of cardiovascular disease is closely connected to adipose tissue inflammation. The links between cardiovascular risk predictors and pro and anti-inflammatory macrophages in human adipose tissue were analysed to gain an insight into the pathophysiology of cardiovascular disease. Design Subcutaneous and visceral adipose tissues were obtained from 79 subjects, 52 living kidney donors (during nephrectomy) and 27 patients with peripheral artery disease (during arterial tree reconstruction). Methods Macrophage subsets were isolated from adipose tissues and analysed by flow cytometry using CD14, CD16, CD36 and CD163 monoclonal antibodies...
January 1, 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/29153764/corrigendum-to-monascus-purpureus-for-statin-and-ezetimibe-intolerant-heterozygous-familial-hypercholesterolaemia-patients-a-clinical-study-atherosclerosis-supplements-30c-2017-86-91
#13
Claudia Stefanutti, Fabio Mazza, Dario Mesce, Claudia Morozzi, Serafina Di Giacomo, Marco Vitale, Mario Pergolini
No abstract text is available yet for this article.
November 16, 2017: Atherosclerosis. Supplements
https://www.readbyqxmd.com/read/29146640/lipid-profiles-and-determinants-of-total-cholesterol-and-hypercholesterolaemia-among-25-74-year-old-urban-and-rural-citizens-of-the-yangon-region-myanmar-a-cross-sectional-study
#14
Aung Soe Htet, Marte Karoline Kjøllesdal, Wai Phyo Aung, Aye Nyein Moe Myint, Win Thuzar Aye, Myint Myint Wai, Than Than Nu, Ei Mon Hla, Pyone Pyone Soe, Nan Wut Yi Tun, Naw Angela, Mya Mya Khaing, Aung Kyaw Htoo, Soe Tun, Pai Thitsar, Theeoo Lwin, San San Wai, Thi Thi Aung, Khin Aye Thant, Wai Wai Aung Po, Seng Taung Gauzam, Tun Tun Naing, Thet Min Tun, Khin San Myint, Kyi Kyi Oo, Nang Kee Myu Mang, Soe Moe Naing, Ko Ko Zaw, Marius Bergsmark Bjertness, Lhamo Yangchen Sherpa, Win Myint Oo, Hein Stigum, Espen Bjertness
OBJECTIVE: The first is to estimate the prevalence of dyslipidaemia (hypercholesterolaemia, hypertriglyceridaemia, high low-density lipoprotein (LDL) level and low high-density lipoprotein (HDL) level), as well as the mean levels of total cholesterol, triglyceride, LDL and HDL, in the urban and rural Yangon Region, Myanmar. The second is to investigate the association between urban-rural location and total cholesterol. DESIGN: Two cross-sectional studies using the WHO STEPS methodology...
November 15, 2017: BMJ Open
https://www.readbyqxmd.com/read/29136293/efficacy-and-safety-of-tofacitinib-for-moderate-to-severe-plaque-psoriasis-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#15
REVIEW
C-M Kuo, T-H Tung, S-H Wang, C-C Chi
The effects of tofacitinib in treating moderate-to-severe plaque psoriasis were unclear. We aimed to assess the effects of tofacitinib in treating moderate-to-severe plaque psoriasis. We searched PubMed, Cochrane Central Register of Controlled Trials, and EMBASE for relevant randomised controlled trials (RCTs), and conducted a systematic review and meta-analysis. Four RCTs with 2,724 participants were included. Compared to placebo, tofacitinib significantly improved psoriasis (≥ 75% reduction in the Psoriasis Area and Severity Index score: 5 mg BID: risk difference (RD) 0...
November 14, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29115200/barley-%C3%AE-glucan-reduces-blood-cholesterol-levels-via-interrupting-bile-acid-metabolism
#16
Yanan Wang, Scott V Harding, Sijo J Thandapilly, Susan M Tosh, Peter J H Jones, Nancy P Ames
Underlying mechanisms responsible for the cholesterol-lowering effect of β-glucan have been proposed, yet have not been fully demonstrated. The primary aim of this study was to determine whether the consumption of barley β-glucan lowers cholesterol by affecting the cholesterol absorption, cholesterol synthesis or bile acid synthesis. In addition, this study was aimed to assess whether the underlying mechanisms are related to cholesterol 7α hydroxylase (CYP7A1) SNP rs3808607 as proposed by us earlier. In a controlled, randomised, cross-over study, participants with mild hypercholesterolaemia (n 30) were randomly assigned to receive breakfast containing 3 g high-molecular weight (HMW), 5 g low-molecular weight (LMW), 3 g LMW barley β-glucan or a control diet, each for 5 weeks...
November 8, 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/29106543/survival-in-homozygous-familial-hypercholesterolaemia-is-determined-by-the-on-treatment-level-of-serum-cholesterol
#17
Gilbert R Thompson, Dirk J Blom, A David Marais, Mary Seed, Gillian J Pilcher, Frederick J Raal
Aims: Homozygous familial hypercholesterolaemia (FH) is a rare inherited disorder characterized by extreme hypercholesterolaemia from birth, accelerated atherosclerosis, and premature death. Many forms of lipid-lowering therapies have been used in the past, but definitive evidence of benefit has been lacking. We therefore undertook a retrospective survey of lipid levels and clinical outcomes of FH homozygotes treated with a combination of lipid-lowering measures between 1990 and 2014 in South Africa and the UK...
July 1, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29097374/people-at-risk-of-familial-hypercholesterolaemia-should-have-dna-test-says-nice
#18
(no author information available yet)
No abstract text is available yet for this article.
November 2, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29096866/monascus-purpureus-for-statin-and-ezetimibe-intolerant-heterozygous-familial-hypercholesterolaemia-patients-a-clinical-study
#19
Claudia Stefanutti, Fabio Mazza, Dario Mesce, Claudia Morozzi, Serafina Di Giacomo, Marco Vitale, Mario Pergolini
BACKGROUND: Hypercholesterolaemia is a major risk factor for cardiovascular disease and requires effective therapy in affected patients. Statins, the mainstay of lipid-lowering therapy, can cause side effects, including myalgia, in some patients. Ezetimibe, is frequently used as an add-on therapy for statins, and is also used as a monotherapy in statin-intolerant patients, however elevations in liver transaminases can occur. We examined the lipid-lowering efficacy of the natural fungal product Monascus purpureus (MP), which contains the natural statin monacolin K...
November 2017: Atherosclerosis. Supplements
https://www.readbyqxmd.com/read/29096839/lipoprotein-apheresis-downregulates-il-1%C3%AE-il-6-and-tnf-%C3%AE-mrna-expression-in-severe-dyslipidaemia
#20
Claudia Stefanutti, Fabio Mazza, Daniela Pasqualetti, Serafina Di Giacomo, Gerald F Watts, Maria Simona Massari, Joel de Neve, Claudia Morozzi, Moritz Fischer
BACKGROUND AND AIMS: Dyslipidaemias are associated with cardiovascular mortality and morbidity, driven by unstable atherosclerotic plaques with inflammatory infiltrates. Levels of messenger RNA (mRNA) for pro-inflammatory cytokines have been positively correlated with atherosclerotic disease progression. Therapeutic lipoprotein apheresis (LA) reduces plasma lipid levels and reduces inflammation. We evaluated the effects of LA on expression of mRNA coding for key pro-inflammatory cytokines in patients with dyslipidaemia, homo-/hetero-zygous familial hypercholesterolaemia (HoFH, HeFH) or hyperlipoprotein(a)aemia [hyperLp(a)] and associated coronary artery disease (CAD)...
November 2017: Atherosclerosis. Supplements
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