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Hypercholesterolaemia

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https://www.readbyqxmd.com/read/28329114/pcsk9-monoclonal-antibodies-reverse-the-pro-inflammatory-profile-of-monocytes-in-familial-hypercholesterolaemia
#1
Sophie J Bernelot Moens, Annette E Neele, Jeffrey Kroon, Fleur M van der Valk, Jan Van den Bossche, Marten A Hoeksema, Renate M Hoogeveen, Johan G Schnitzler, Marie T Baccara-Dinet, Garen Manvelian, Menno P J de Winther, Erik S G Stroes
Aims: Migration of monocytes into the arterial wall contributes to arterial inflammation and atherosclerosis progression. Since elevated low-density lipoprotein cholesterol (LDL-C) levels have been associated with activation of plasma monocytes, intensive LDL-C lowering may reverse these pro-inflammatory changes. Using proprotein convertase subtilisin/kexin type 9 (PCSK9) monoclonal antibodies (mAbs) which selectively reduce LDL-C, we studied the impact of LDL-C lowering on monocyte phenotype and function in patients with familial hypercholesterolaemia (FH) not using statins due to statin-associated muscle symptoms...
February 18, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28327405/five-year-experience-of-scoring-criteria-for-familial-hypercholesterolaemia-fh-genetic-testing-in-wales-should-the-criteria-be-refined-to-include-age
#2
K Haralambos, P Ashfield-Watt, R Edwards, R Gingell, D Townsend, S D Whatley, D B N Datta, I F W McDowell
No abstract text is available yet for this article.
December 2016: Atherosclerosis
https://www.readbyqxmd.com/read/28327402/validation-and-utility-of-a-new-ngs-assay-for-familial-hypercholesterolaemia-incorporating-12-ldl-c-raising-snps
#3
Julie Honeychurch, E Watson, A Hills, P Dean, G Woodward, M Wadsley, J Davies, S Humphries, G Bayly, M Williams
No abstract text is available yet for this article.
December 2016: Atherosclerosis
https://www.readbyqxmd.com/read/28327401/validation-of-low-density-lipoprotein-correction-factors-in-a-multi-ethnic-familial-hypercholesterolaemia-population-at-a-north-london-lipid-clinic
#4
A Goyale, A Jain, M Sharifi, A Gallivan, N Hoshi, J W Presaud, D R Nair
No abstract text is available yet for this article.
December 2016: Atherosclerosis
https://www.readbyqxmd.com/read/28327399/cardiovascular-biomarkers-in-monogenic-familial-hypercholesterolaemia-and-polygenic-hypercholesterolaemia
#5
Mahtab Sharifi, Anjly Jain, Jahm Persaud, Steve E Humphries, Devaki Nair
No abstract text is available yet for this article.
December 2016: Atherosclerosis
https://www.readbyqxmd.com/read/28327396/4-years-cascade-genetic-testing-for-familial-hypercholesterolaemia-in-england-increased-referrals-and-ascertainment
#6
Alison Hills, Julie Honeychurch, Joanne Davies, Carol Robinson, Graham Bayly, Andrew Taylor, Mahmoud Barbir, Jane Breen, Melanie Watson, Nigel Wheeldon, Maggie Williams
No abstract text is available yet for this article.
December 2016: Atherosclerosis
https://www.readbyqxmd.com/read/28327395/using-pass-database-and-geographic-information-systems-gis-to-map-familial-hypercholesterolaemia-fh-diagnoses-in-england-and-wales
#7
K Kate Haralambos, J Whitmore
No abstract text is available yet for this article.
December 2016: Atherosclerosis
https://www.readbyqxmd.com/read/28327394/early-identification-of-familial-hypercholesterolaemia-fh-the-prevention-of-cardiovascular-disease-cvd
#8
J Lungley, Z Jayne, D Harvey, D R Nair
No abstract text is available yet for this article.
December 2016: Atherosclerosis
https://www.readbyqxmd.com/read/28327392/the-critical-importance-of-segregation-analysis-in-the-management-of-patients-and-their-families-with-suspected-familial-hypercholesterolaemia-3-examples-from-the-bristol-fh-clinic
#9
Lisa Gritzmacher, G R Bayly, Maggie Williams, Alison Hills, Julie Honeychurch, P F Downie
No abstract text is available yet for this article.
December 2016: Atherosclerosis
https://www.readbyqxmd.com/read/28327391/detection-assessment-and-treatment-of-children-with-familial-hypercholesterolaemia-in-scotland
#10
Alison Cozens, Susan McMahon, Janet Purves, Zosia Miedzybrodska, E Mason
No abstract text is available yet for this article.
December 2016: Atherosclerosis
https://www.readbyqxmd.com/read/28327390/familial-hypercholesterolaemia-fh-finding-the-needle-in-a-haystack-in-a-scottish-population
#11
Emma Gellatly
No abstract text is available yet for this article.
December 2016: Atherosclerosis
https://www.readbyqxmd.com/read/28327387/estimation-of-the-prevalence-of-cholesteryl-ester-storage-disorder-cesd-in-a-cohort-of-patients-with-clinical-features-of-familial-hypercholesterolaemia
#12
Pauline Ashfield-Watt, Kate Haralambos, Rhiannon Edwards, Delyth Townsend, Rob Gingell, Kah Wa Li, Steve E Humphries, Ian McDowell
No abstract text is available yet for this article.
December 2016: Atherosclerosis
https://www.readbyqxmd.com/read/28325998/glucomannan-and-glucomannan-plus-spirulina-enriched-pork-affect-liver-fatty-acid-profile-ldl-receptor-expression-and-antioxidant-status-in-zucker-fa-fa-rats-fed-atherogenic-diets
#13
Laura González-Torres, Cátia Matos, Miguel Vázquez-Velasco, Jorge A Santos-López, Iria Sánchez-Martínez, Camino García-Fernández, Sara Bastida, Juana Benedí, Francisco J Sánchez-Muniz
We evaluated the effects of glucomannan or glucomannan plus spirulina-restructured pork (RP) on liver fatty acid profile, desaturase/elongase enzyme activities and oxidative status of Zucker fa/fa rats for seven weeks. Control (C), glucomannan (G) and glucomannan/spirulina (GS)-RP; HC (cholesterol-enriched control), HG and HGS (cholesterol-enriched glucomannan and glucomannan/spirulina-RP) experimental diets were tested. Increased metabolic syndrome markers were found in C, G and GS rats. Cholesterol feeding increased liver size, fat, and cholesterol and reduced antioxidant enzyme levels and expressions...
2017: Food & Nutrition Research
https://www.readbyqxmd.com/read/28319109/the-broad-study-a-randomised-controlled-trial-using-a-whole-food-plant-based-diet-in-the-community-for-obesity-ischaemic-heart-disease-or-diabetes
#14
N Wright, L Wilson, M Smith, B Duncan, P McHugh
BACKGROUND/OBJECTIVE: There is little randomised evidence using a whole food plant-based (WFPB) diet as intervention for elevated body mass index (BMI) or dyslipidaemia. We investigated the effectiveness of a community-based dietary programme. Primary end points: BMI and cholesterol at 6 months (subsequently extended). SUBJECTS: Ages 35-70, from one general practice in Gisborne, New Zealand. Diagnosed with obesity or overweight and at least one of type 2 diabetes, ischaemic heart disease, hypertension or hypercholesterolaemia...
March 20, 2017: Nutrition & Diabetes
https://www.readbyqxmd.com/read/28314542/impact-of-implementing-electronic-clinical-practice-guidelines-for-the-diagnosis-control-and-treatment-of-cardiovascular-risk-factors-a-pre-post-controlled-study
#15
Eva Comin, Arantxa Catalan-Ramos, Manuel Iglesias-Rodal, Maria Grau, Jose Luis Del Val, Alicia Consola, Ester Amado, Angels Pons, Manel Mata-Cases, Alicia Franzi, Ramon Ciurana, Eva Frigola, Xavier Cos, Josep Davins, Jose M Verdu-Rotellar
OBJECTIVE: To evaluate the impact of computerized clinical practice guidelines on the management, diagnosis, treatment, control, and follow-up of the main cardiovascular risk factors: hypertension, hypercholesterolaemia, and type 2 diabetes mellitus. DESIGN: Pre-post controlled study. SETTING: Catalonia, autonomous community located in north-eastern Spain. PARTICIPANTS: Individuals aged 35-74 years assigned to general practitioners of the Catalan Health Institute...
March 14, 2017: Atencion Primaria
https://www.readbyqxmd.com/read/28302660/rhabdomyolysis-induced-compartment-syndrome-secondary-to-atorvastatin-and-strenuous-exercise
#16
Louise Dunphy, Rossel Morhij, Sarah Tucker
A 50-year-old male UK resident with a history of hypertension and hypercholesterolaemia presented to the emergency department with a 48-hour history of sudden onset bilateral thigh swelling and pain unrelieved by regular analgesia. 3 days prior to presentation, he performed a vigorous workout in the gym. His medications included ramipril 5 mg once daily and atorvastatin 20 mg at night time. He was a non-smoker and did not consume alcohol. He reported no known drug allergies. Physical examination confirmed bilateral swollen thighs, with no overlying skin changes, clinically suggestive of compartment syndrome...
March 16, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28301218/retinal-pathology-is-associated-with-increased-blood-retina-barrier-permeability-in-a-diabetic-and-hypercholesterolaemic-pig-model-beneficial-effects-of-the-lppla2-inhibitor-darapladib
#17
Nimish K Acharya, Xin Qi, Eric L Goldwaser, George A Godsey, Hao Wu, Mary C Kosciuk, Theresa A Freeman, Colin H Macphee, Robert L Wilensky, Venkat Venkataraman, Robert G Nagele
Using a porcine model of diabetes mellitus and hypercholesterolaemia, we previously showed that diabetes mellitus and hypercholesterolaemia is associated with a chronic increase in blood-brain barrier permeability in the cerebral cortex, leading to selective binding of immunoglobulin G and deposition of amyloid-beta1-42 peptide in pyramidal neurons. Treatment with Darapladib (GlaxoSmithKline, SB480848), an inhibitor of lipoprotein-associated phospholipase-A2, alleviated these effects. Here, investigation of the effects of chronic diabetes mellitus and hypercholesterolaemia on the pig retina revealed a corresponding increased permeability of the blood-retina barrier coupled with a leak of plasma components into the retina, alterations in retinal architecture, selective IgG binding to neurons in the ganglion cell layer, thinning of retinal layers due to cell loss and increased glial fibrillary acidic protein expression in Müller cells, all of which were curtailed by treatment with Darapladib...
March 1, 2017: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/28292782/exploring-the-fitness-hypothesis-in-als-a-population-based-case-control-study-of-parental-cause-of-death-and-lifespan
#18
Anne E Visser, Meinie Seelen, Alexander Hulsbergen, Joris de Graaf, Anneke J van der Kooi, Joost Raaphorst, Jan H Veldink, Leonard H van den Berg
OBJECTIVE: To investigate the theory of premorbid fitness in amyotrophic lateral sclerosis (ALS), we studied whether a common genetic profile for physical or cardiovascular fitness was manifest in progenitors leading to less cardiovascular death and a longer lifespan in parents of patients with ALS compared with parents of controls. METHODS: Patient and disease characteristics, levels of physical activity, parental cause and age of death were obtained using a structured questionnaire from a population-based, case-control study of ALS in the Netherlands...
March 14, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/28285379/evolocumab-for-treating-primary-hypercholesterolaemia-and-mixed-dyslipidaemia-an-evidence-review-group-perspective-of-a-nice-single-technology-appraisal
#19
Christopher Carroll, Paul Tappenden, Rachid Rafia, Jean Hamilton, Duncan Chambers, Mark Clowes, Paul Durrington, Nadeem Qureshi, Anthony S Wierzbicki
As part of its single technology appraisal (STA) process, the UK National Institute for Health and Care Excellence (NICE) invited the manufacturer of evolocumab (Amgen) to submit evidence on the clinical and cost effectiveness of evolocumab. The appraisal assessed evolocumab as monotherapy or in combination with a statin with or without ezetimibe, or in combination with ezetimibe (without statin therapy), in adult patients with primary hypercholesterolaemia (which includes mixed dyslipidaemia), for whom statins do not provide optimal control of their low-density lipoprotein cholesterol (LDL-C) levels and/or for whom statins are contraindicated or not tolerated...
March 11, 2017: PharmacoEconomics
https://www.readbyqxmd.com/read/28283862/failure-to-control-hypercholesterolaemia-in-the-irish-adult-population-cross-sectional-analysis-of-the-baseline-wave-of-the-irish-longitudinal-study-on-ageing-tilda
#20
C Murphy, E Shelley, A M O'Halloran, T Fahey, R A Kenny
BACKGROUND: Hypercholesterolaemia is an important modifiable risk factor for cardiovascular disease (CVD) which requires monitoring and management at a population level. AIMS: This study aims to describe the distribution of serum cholesterol in a community living population of older adults in Ireland and to examine the awareness, treatment and control of hypercholesterolaemia according to CVD risk status. METHOD: This is a cross-sectional study in a nationally representative sample of adults aged 50-79 years (n = 5287)...
March 10, 2017: Irish Journal of Medical Science
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