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Audrey M Neyrinck, Sophie Hiel, Caroline Bouzin, Vicenta Garcia Campayo, Patrice D Cani, Laure B Bindels, Nathalie M Delzenne
BACKGROUND: Non-digestible carbohydrates present in cereals such as fructans and arabinoxylans represent promising prebiotic nutrients to prevent the development of obesity and related metabolic disorders. OBJECTIVE AND DESIGN:  The aim of this study was to determine the corrective effects of wheat bran-derived arabinoxylan oligosaccharides in obese mice fed a western diet (WD). WD was given for 4 weeks before wheat bran extract (WBE) supplementation (5%) for an additional 4 weeks, whereas a control group received the standard diet...
March 7, 2018: Nutrition & Diabetes
Irundika H K Dias, Ivana Milic, Gregory Y H Lip, Andrew Devitt, M Cristina Polidori, Helen R Griffiths
Oxysterols (OHC) are biologically active cholesterol metabolites circulating in plasma that may be formed enzymatically (e.g. 24S-OHC, 25-OHC and 27-OHC) or by autoxidative mechanisms (e.g. 7-ketocholesterol, 7β-OHC and 25-OHC). Oxysterols are more soluble than cholesterol and are reported to exert inflammatory, cytoprotective and apoptotic effects according to concentration and species. Esterified oxysterols have been analysed in people with dementia and cardiovascular diseases although there is no consistent relationship between oxysterol esters and disease...
February 17, 2018: Redox Biology
S Yokota, J P Ottervanger, M Mouden, M J de Boer, P L Jager, J R Timmer
PURPOSE: Normal myocardial perfusion imaging (MPI) is associated with excellent prognosis. However, in patients with persisting symptoms, it may be difficult to determine the patients in whom invasive angiography is justified to rule out false negative MPI. We evaluated predictors for severe stenosis at invasive angiography in patients with persisting symptoms after normal MPI. METHODS: 229 consecutive patients with normal MPI, without previous bypass surgery, underwent invasive angiography within 6 months...
March 2, 2018: Netherlands Heart Journal
Rohit A Sinha, Brijesh K Singh, Paul M Yen
It has been known for a long time that thyroid hormones have prominent effects on hepatic fatty acid and cholesterol synthesis and metabolism. Indeed, hypothyroidism has been associated with increased serum levels of triglycerides and cholesterol as well as non-alcoholic fatty liver disease (NAFLD). Advances in areas such as cell imaging, autophagy and metabolomics have generated a more detailed and comprehensive picture of thyroid-hormone-mediated regulation of hepatic lipid metabolism at the molecular level...
February 23, 2018: Nature Reviews. Endocrinology
Yuan-Yang Cheng, Chung-Lan Kao, Shih-Yi Lin, Shin-Tsu Chang, Tz-Shiang Wei, Shih-Ni Chang, Ching-Heng Lin
OBJECTIVES: It has been proven that statin can protect synovial joints from developing osteoarthritis through its anti-inflammatory effects. However, studies on the effect of statins on spinal degenerative joint diseases are few and limited to in vitro studies. Therefore, we investigated the relationship between the statin dosage and the development of spinal degenerative joint diseases. DESIGN: A retrospective cohort study. SETTING: Patients registered in Taiwan National Health Insurance Research Database...
February 8, 2018: BMJ Open
Insa Feinkohl, Georg Winterer, Tobias Pischon
BACKGROUND: Lipid imbalance is linked to age-related cognitive impairment, but its role in postoperative cognitive dysfunction (POCD) is unknown. Here, we present a systematic review and meta-analysis on dyslipidaemia, lipid-lowering treatment and POCD risk. METHODS: PubMed, Ovid SP and Cochrane databases were searched for longitudinal studies that reported on associations of any measure of dyslipidaemia and/or lipid-lowering treatment with POCD as relative risks (RRs) or ORs...
February 2, 2018: Journal of Epidemiology and Community Health
Theodosios D Filippatos, Angelos Liontos, Eliza C Christopoulou, Moses S Elisaf
Over the last 3 decades, hypolipidaemic treatment has significantly reduced both cardiovascular (CV) risk and events, with statins being the cornerstone of this achievement. Nevertheless, residual CV risk and unmet goals in hypolipidaemic treatment make novel options necessary. Recently marketed monoclonal antibodies against proprotein convertase subtilisin/kexin type 9 (PCSK9) have shown the way towards innovation, while other ways of PCSK9 inhibition like small interfering RNA (Inclisiran) are already being tested...
February 8, 2018: Current Vascular Pharmacology
Giuseppa Maresca, Maria C De Cola, Santina Caliri, Rosaria De Luca, Alfredo Manuli, Ileana Scarcella, Giuseppe Silvestri, Placido Bramanti, Michele Torrisi, Rocco S Calabrò, Alessia Bramanti
Introduction Elderly care is a worldwide social and economic challenge for the public health system, and it requires the development of new management strategies. Telemedicine provides an innovative approach towards elderly care, especially for those with chronic diseases. In this study, we aimed to evaluate the potential role of a multidisciplinary telemedicine approach for improving elderly quality of life. Methods Twenty-two participants received weekly vital parameter monitoring and nutritional counselling, biweekly psychological counselling and a monthly consultation with a neurologist...
January 1, 2018: Journal of Telemedicine and Telecare
Aleksandra Pelczarska, Michał Jakubczyk, Joanna Jakubiak-Lasocka, Maciej Banach, Małgorzata Myśliwiec, Marcin Gruchała, Maciej Niewada
BACKGROUND AND AIMS: Familial hypercholesterolaemia (FH) elevates the cholesterol level and increases the risk of coronary events and death. Early detection and treatment reduce this risk. We aimed to determine the cost-effectiveness of FH screening in Poland in children, first job takers, and after an acute coronary syndrome (ACS) event, each followed by a cascade screening in the relatives of the positively-diagnosed subjects. METHODS: A decision tree was constructed to model the diagnosis process...
January 31, 2018: Atherosclerosis
Cèlia Rodríguez-Borjabad, Daiana Ibarretxe, Josefa Girona, Raimon Ferré, Albert Feliu, Núria Amigó, Eugenio Guijarro, Luis Masana, Núria Plana
BACKGROUND AND AIMS: Familial hypercholesterolaemia (FH) is underdiagnosed in children. In addition to lipid concentrations, lipoprotein particle quantity and quality could influence cardiovascular risk. We aimed to perform a comprehensive plasma lipid study, including lipoprotein particle number and size assessment by two-dimensional nuclear magnetic resonance (2D-1H-NMR), in children with FH compared to non-affected children and to evaluate the clinical value of these factors as subclinical atherosclerosis biomarkers...
January 31, 2018: Atherosclerosis
Marie Dahl, Lars Frost, Rikke Søgaard, Ib Christian Klausen, Vibeke Lorentzen, Jes Lindholt
BACKGROUND: Reducing women's cardiovascular risk and the economic costs associated with cardiovascular diseases (CVD) and diabetes (DM) continues to be a challenge. Whether a multifaceted CVD screening programme is beneficial as a preventive strategy in women remains uncertain. The aim of this study was to investigate the prevalence of CVD and DM as well as the acceptability toward screening and preventive actions. METHODS: An observational study was performed among all women born in 1936, 1941, 1946 and 1951 living in Viborg Municipality, Denmark, from October 2011...
February 5, 2018: BMC Cardiovascular Disorders
Krzysztof Chlebus, Barbara Cybulska, Marcin Gruchała, Anna Smaga, Katarzyna Wróbel, Bogdan Wojtyniak, Marcin Pajkowski, Piotr Jankowski, Tomasz Zdrojewski
BACKGROUND: Familial hypercholesterolaemia (FH) is the most common genetic disease leading to premature atherosclerosis. AIM: The aim of the study was to evaluate the prevalence, diagnosis, and treatment of FH in outpatient practice in Poland. METHODS: The study included a representative sample of 147 primary care physicians, cardiologists, and diabetologists caring for 2812 adult patients with hypercholesterolaemia and low-density lipoprotein cholesterol (LDL-C) level >1...
February 5, 2018: Kardiologia Polska
Hee Nam Kim, Sun-Seog Kweon, Min-Ho Shin
We aimed to evaluate the prevalence of familial hypercholesterolaemia (FH) in a subject with hypercholesterolaemia from two population-based cohorts in South Korea. A total of 283 subjects with total cholesterol levels of 290 mg/dL (7.5 mmol/L) or higher were selected from the Namwon and Dong-gu Studies. We used next generation sequencing (NGS) to detect mutations in low-density lipoprotein receptors (LDLR), apolipoprotein B (APOB) and proprotein convertase subtilisin/kexin type 9 (PCSK9) genes. We have confirmed 17 different mutations of the LDLR, APOB and PCSK9 in 23 subjects (8...
January 2018: Chonnam Medical Journal
Handrean Soran, Safwaan Adam, Jamal B Mohammad, Jan H Ho, Jonathan D Schofield, See Kwok, Tarza Siahmansur, Yifen Liu, Akheel A Syed, Shaishav S Dhage, Claudia Stefanutti, Rachelle Donn, Rayaz A Malik, Maciej Banach, Paul N Durrington
Hypercholesterolaemia is amongst the most common conditions encountered in the medical profession. It remains one of the key modifiable cardiovascular risk factors and there have been recent advances in the risk stratification methods and treatment options available. In this review, we provide a background into hypercholesterolaemia for non-specialists and consider the merits of the different risk assessment tools available. We also provide detailed considerations as to: i) when to start treatment, ii) what targets to aim for and iii) the role of low density lipoprotein cholesterol...
January 2018: Archives of Medical Science: AMS
Katrina Ellis, Jing Pang, Damon Bell, John Burnett, Carl Schultz, Graham Hillis, Gerald Watts
No abstract text is available yet for this article.
August 2017: Atherosclerosis
Jing Pang, Arun Abraham, Timothy R Bates, Damon A Bell, Amanda J Hooper, John R Burnett, Gerald F Watts
No abstract text is available yet for this article.
August 2017: Atherosclerosis
Jacqueline Dm Ryan, Jing Pang, Gerald F Watts, Alistair Vickery
No abstract text is available yet for this article.
August 2017: Atherosclerosis
Radzi Rahmat, Yung-An Chua, Zaliha Ismail, Noor Alicezah Mohd Kasim, Thuhairah Abdul Rahman, Anis Safura Ramli, Suraya Abdul Razak, Hapizah Nawawi
No abstract text is available yet for this article.
August 2017: Atherosclerosis
Paul Downie, Lisa Gritzmacher, Frances Palmer, Graham Bayly
No abstract text is available yet for this article.
August 2017: Atherosclerosis
Paola Bigolin, Antonio Antonucci, Raffaella Marin, Daniela Vianello, Sandra Bertocco, Lorenzo Previato, Fabrizio Fabris, Enzo Manzato, Sabina Zambon, Alberto Zambon
No abstract text is available yet for this article.
August 2017: Atherosclerosis
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