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Hypercholesterolaemia

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https://www.readbyqxmd.com/read/28235412/the-herbal-formula-kh-204-is-protective-against-erectile-dysfunction-by-minimizing-oxidative-stress-and-improving-lipid-profiles-in-a-rat-model-of-erectile-dysfunction-induced-by-hypercholesterolaemia
#1
Hoon Jang, Woong Jin Bae, Su Jin Kim, Hyuk Jin Cho, Seung Mo Yuk, Dong Seok Han, Chang Shik Youn, Eun Bi Kwon, Sung Yeoun Hwang, Sae Woong Kim
BACKGROUND: Hypercholesterolaemia (HC) is a major risk factor for ischemic heart disease and is also known to be a risk factor for erectile dysfunction (ED). ED caused by HC is thought to be related to HC-induced oxidative stress damage in the vascular endothelium and erectile tissue. KH-204 is an herbal formula with a strong antioxidant effect. We evaluated the effects of KH-204 on erectile function in a rat model of HC-induced ED. METHODS: Male Sprague-Dawley rats (6 weeks old) were divided into normal control, high-fat and cholesterol diet (HFC), and HFC with KH-204 treatment (HFC + KH) groups (n = 12 each)...
February 24, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28220743/analysis-of-mutations-causing-familial-hypercholesterolaemia-in-black-south-african-patients-of-different-ancestr
#2
U K Ibe, R Whittall, S E Humphries, G Pilcher, F Raal
BACKGROUND: Familial hypercholesterolaemia (FH) is usually caused by mutations in three genes (LDLR, APOB and PCSK9). OBJECTIVE: To identify the spectrum of FH-causing mutations in black South African (SA) patients. METHODS: DNA samples of 16 unrelated South African FH patients with elevated low-density lipoprotein cholesterol levels, tendon xanthomas and corneal arcus (3 clinically homozygous FH and 13 heterozygous FH) of ethnic African origin were screened for mutations in the LDLR (coding region, promoter and intron/exon boundaries), APOB (part of exon 26) and PCSK9 genes (exon 7), using high-resolution melting...
January 30, 2017: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/28215937/long-term-treatment-with-evolocumab-added-to-conventional-drug-therapy-with-or-without-apheresis-in-patients-with-homozygous-familial-hypercholesterolaemia-an-interim-subset-analysis-of-the-open-label-taussig-study
#3
Frederick J Raal, G Kees Hovingh, Dirk Blom, Raul D Santos, Mariko Harada-Shiba, Eric Bruckert, Patrick Couture, Handrean Soran, Gerald F Watts, Christopher Kurtz, Narimon Honarpour, Lihua Tang, Sree Kasichayanula, Scott M Wasserman, Evan A Stein
BACKGROUND: Homozygous familial hypercholesterolaemia is a genetic disorder characterised by substantially raised LDL cholesterol, reduced LDL receptor function, xanthomas, and cardiovascular disease before age 20 years. Conventional therapy is with statins, ezetimibe, and apheresis. We aimed to assess the long-term safety and efficacy of the proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor evolocumab in a subset of patients with homozygous familial hypercholesterolaemia enrolled in an open-label, non-randomised phase 3 trial...
February 16, 2017: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/28206728/laparoscopic-roux-en-y-gastric-bypass-vs-laparoscopic-sleeve-gastrectomy-for-morbid-obesity-a-systematic-review-and-meta-analysis-of-lipid-effects-at-one-year-post-surgery
#4
Elisenda Climent, David Benaiges, Juan Pedro-Botet, Albert Goday, Ivan Solà, José M Ramón, Juana A Flores-LE Roux, Miguel Á Checa
INTRODUCTION: Results of the effects of Roux-en-Y gastric bypass (GB) and sleeve gastrectomy (SG) on triglyceride and high-density lipoprotein (HDL) cholesterol levels are controversial. Moreover, previous meta-analyses focused on global dyslipidaemia remission, but did not include the separate remission rates of the different lipid fractions. Hence, the aim of the present meta-analysis was to compare the outcomes (concentration change and remission rates) of GB and SG on diverse lipid disorders one year post-bariatric surgery (BS)...
February 15, 2017: Minerva Endocrinologica
https://www.readbyqxmd.com/read/28186938/an-online-questionnaire-survey-of-uk-general-practitioners-knowledge-and-management-of-familial-hypercholesterolaemia
#5
See Kwok, Jing Pang, Safwaan Adam, Gerald F Watts, Handrean Soran
OBJECTIVE: Early diagnosis and treatment of heterozygous familial hypercholesterolaemia (HeFH) is known to be associated with reduced mortality from premature coronary artery disease, but HeFH remains underdiagnosed. This survey aims to determine knowledge and current management of HeFH in general practice. SETTING: An online questionnaire was administered to general practitioners' (GPs') in the North West of England to assess their knowledge and management of HeFH...
November 9, 2016: BMJ Open
https://www.readbyqxmd.com/read/28169869/low-density-lipoprotein-receptor-mutational-analysis-in-diagnosis-of-familial-hypercholesterolemia
#6
Mafalda Bourbon, Ana C Alves, Eric J Sijbrands
PURPOSE OF REVIEW: To present up to date evidence on the pathogenicity of low-density lipoprotein receptor (LDLR) variants and to propose a strategy that is suitable for implementation in the clinical work-up of familial hypercholesterolaemia. RECENT FINDINGS: More than 1800 variants have been described in the LDLR gene of patients with a clinical diagnosis of familial hypercholesterolaemia; however, less than 15% have functional evidence of pathogenicity. SUMMARY: The spectrum of variants in the LDLR identified in patients with clinical familial hypercholesterolaemia is increasing as novel variants are still being reported...
February 6, 2017: Current Opinion in Lipidology
https://www.readbyqxmd.com/read/28159968/impact-of-clinical-signs-and-genetic-diagnosis-of-familial-hypercholesterolaemia-on-the-prevalence-of-coronary-artery-disease-in-patients-with-severe-hypercholesterolaemia
#7
Hayato Tada, Masa-Aki Kawashiri, Atsushi Nohara, Akihiro Inazu, Hiroshi Mabuchi, Masakazu Yamagishi
No abstract text is available yet for this article.
February 4, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28144991/hypercholesterolaemia-screening-in-type-1-diabetes-a-difference-of-opinion
#8
T Candler, O Mahmoud, J Edge, J Hamilton Shield
AIM: To assess cholesterol screening of children with Type 1 diabetes by diabetes professionals using a survey of current practice, given that National Institute of Health and Care Excellence guidelines on childhood Type 1 diabetes do not recommend cholesterol screening, yet the National Paediatric Diabetes Audit has an annual cholesterol measure (>12 years) as a key outcome indicator. METHODS: An online survey was sent to 280 members of the Association of Children's Diabetes Clinicians to assess cholesterol screening practice in children...
February 1, 2017: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/28143840/educational-intervention-to-improve-effectiveness-in-treatment-and-control-of-patients-with-high-cardiovascular-risk-in-low-resource-settings-in-argentina-study-protocol-of-a-cluster-randomised-controlled-trial
#9
Pablo Gulayin, Vilma Irazola, Alfredo Lozada, Martin Chaparro, Marilina Santero, Laura Gutierrez, Rosana Poggio, Andrea Beratarrechea, Adolfo Rubinstein
INTRODUCTION: Hypercholesterolaemia is estimated to cause 2.6 million deaths annually and one-third of the cases of ischaemic heart disease. In Argentina, the prevalence of hypercholesterolaemia increased between 2005 and 2013 from 27.9% to 29.8%. Only one out of four subjects with a self-reported diagnosis of coronary heart disease is taking statins. Since 2014, statins (simvastatin 20 mg) are part of the package of drugs provided free-of-charge for patients according to cardiovascular disease (CVD) risk stratification...
January 31, 2017: BMJ Open
https://www.readbyqxmd.com/read/28139200/-costs-of-healthcare-resource-consumption-after-a-myocardial-infarction-in-france-an-estimate-from-a-medicoadministrative-database-gsb
#10
F Philippe, P Blin, S Bouée, C Laurendeau, E Torreton, J Gourmelin, M Velkovski-Rouyer, L Levy-Bachelot, G Steg
OBJECTIVE: To estimate the costs of healthcare resource consumption in the year preceding and the year following a myocardial infarction (MI). PATIENTS AND METHODS: A historical cohort of patients experiencing an MI in France between 2007 and 2011 was extracted from the échantillon généraliste de bénéficiaires, a 1/97th sample of all beneficiaries of public health insurance in France. RESULTS: A total of 1920 patients experiencing an MI were identified...
January 27, 2017: Annales de Cardiologie et D'angéiologie
https://www.readbyqxmd.com/read/28134590/supervised-exercise-therapy-in-the-management-of-peripheral-arterial-disease-an-assessment-of-compliance
#11
Thomas M Aherne, Elrasheid A H Kheirelseid, Michael Boland, Shane Carr, Thekra Al-Zabi, Khalid Bashar, Daragh Moneley, Austin Leahy, Noel McCaffrey, Peter Naughton
BACKGROUND: Supervised exercise therapy (SET) is an effective option in the management of peripheral arterial disease (PAD). Unfortunately, poor compliance remains prevalent. This study aimed to assess patient exercise compliance and to identify factors influencing symptomatic improvement and SET participation. PATIENTS AND METHODS: Data regarding attendance at SET for this cohort study were extracted from a prospectively maintained database of patients with claudication attending SET at Dublin City University...
January 30, 2017: VASA. Zeitschrift Für Gefässkrankheiten
https://www.readbyqxmd.com/read/28131047/long-term-outcome-in-53-patients-with-homozygous-familial-hypercholesterolaemia-in-a-single-centre-in-france
#12
Eric Bruckert, Olga Kalmykova, Randa Bittar, Valérie Carreau, Sophie Béliard, Samir Saheb, David Rosenbaum, Dominique Bonnefont-Rousselot, Daniel Thomas, Corinne Emery, Babak Khoshnood, Alain Carrié
BACKGROUND AND AIMS: Homozygous familial hypercholesterolaemia (HoFH) is a rare inherited condition characterized by elevated plasma low-density lipoprotein-cholesterol (LDL-C) levels, severe, accelerated atherosclerosis and premature coronary heart disease. We evaluated cardiovascular complications in HoFH patients over extended follow-up and investigated their association with changes in cholesterol over time, as well as total cholesterol burden. METHODS: In this retrospective single-centre study, 53 patients (baseline mean ± standard deviation [SD], total cholesterol 15...
February 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28128061/the-effect-of-proprotein-convertase-subtilisin-kexin-type-9-and-its-inhibition-on-glucose-metabolism-and-cardiovascular-risk-we-should-do-better-the-second-time-after-statins
#13
Vasilios G Athyros, Konstantinos Tziomalos, Michael Doumas, George Sfikas, Asterios Karagiannis
BACKGROUND: Statins remain the cornerstone of hypolipidaemic drug treatment. However, statins exert adverse effects on glucose metabolism. Given that new onset diabetes mellitus (NODM) and worsening of glucose control in patients with established type 2 diabetes mellitus (T2DM) is related to low density lipoprotein cholesterol (LDL-C) reduction, it would be of great interest to investigate if this is also the case for proprotein convertase subtilisin-kexin type 9 (PCSK9) inhibitors, which have recently be licensed for the treatment of hypercholesterolaemia...
January 25, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28123770/predictors-of-peripheral-arterial-disease-in-sle-change-with-patient-s-age
#14
Jose-Gabriel Erdozain, Irama Villar, Javier Nieto, Ioana Ruiz-Arruza, Guillermo Ruiz-Irastorza
OBJECTIVE: To analyse the differential influence of risk factors of peripheral artery disease (PAD) according to age in patients with SLE. METHODS: 216 patients from the Lupus-Cruces cohort were divided in three age groups: ≤34 years, 35-49 years and ≥50 years. A low ankle-brachial index defined PAD. Significant variables were identified by univariant and multivariant analysis in each age group. RESULTS: Different factors were identified in different age groups: antiphospholipid antibodies/antiphospholipid syndrome and glucocorticoids in patients ≤34 years; in patients 35-49 years old, hypertension was the only statistically significant predictor, although a trend was observed for fibrinogen levels; a trend was observed for hypercholesterolaemia in those ≥50 years...
2017: Lupus Science & Medicine
https://www.readbyqxmd.com/read/28119386/survival-prospects-after-acute-myocardial-infarction-in-the-uk-a-matched-cohort-study-1987-2011
#15
Lisanne A Gitsels, Elena Kulinskaya, Nicholas Steel
OBJECTIVES: Estimate survival after acute myocardial infarction (AMI) in the general population aged 60 and over and the effect of recommended treatments. DESIGN: Cohort study in the UK with routinely collected data between January 1987 and March 2011. SETTING: 310 general practices that contributed to The Health Improvement Network (THIN) database. PARTICIPANTS: 4 cohorts who reached the age of 60, 65, 70, or 75 years between 1987 and 2011 included 16 744, 43 528, 73 728, and 76 392 participants, respectively...
January 24, 2017: BMJ Open
https://www.readbyqxmd.com/read/28104607/pcsk9-inhibitors-for-hypercholesterolaemia
#16
Patricia McGettigan, Robin E Ferner
No abstract text is available yet for this article.
January 19, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28104544/molecular-genetics-of-familial-hypercholesterolemia-in-israel-revisited
#17
Ronen Durst, Uche Ken Ibe, Shoshi Shpitzen, Daniel Schurr, Osnat Eliav, Marta Futema, Ros Whittall, Auryan Szalat, Vardiella Meiner, Hilla Knobler, Dov Gavish, Yaakov Henkin, Avishay Ellis, Ardon Rubinstein, Dror Harats, Rafael Bitzur, Bruno Hershkovitz, Steve E Humphries, Eran Leitersdorf
BACKGROUND AND AIMS: Familial hypercholesterolemia (FH) is an autosomal dominant disease caused by mutations in the genes for LDL receptor (LDLR), apolipoprotein B (APOB) and proprotein convertase subtilisin/kexin type9 (PCSK9). The purpose of the current investigation was to define the current spectrum of mutations causing FH in Israel. METHODS: New families were collected through the MEDPED (Make Early Diagnosis Prevent Early Death) FH program. Molecular analysis of the LDLR, PCSK9 and APOB genes was done using High Resolution Melt and direct sequencing in 67 index cases...
February 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28087751/odyssey-escape-is-pcsk9-inhibition-the-trojan-horse-for-the-use-of-lipoprotein-apheresis-in-familial-hypercholesterolaemia
#18
EDITORIAL
Gerald F Watts, Claudia Stefanutti
No abstract text is available yet for this article.
December 21, 2016: European Heart Journal
https://www.readbyqxmd.com/read/28067533/frequent-coexistence-of-chronic-heart-failure-and-chronic-obstructive-pulmonary-disease-in-respiratory-and-cardiac-outpatients-evidence-from-suspirium-a-multicentre-italian-survey
#19
Raffaele Griffo, Antonio Spanevello, Pier Luigi Temporelli, Pompilio Faggiano, Mauro Carone, Giovanna Magni, Nicolino Ambrosino, Luigi Tavazzi
Background Chronic heart failure (CHF) and chronic obstructive pulmonary disease (COPD) frequently coexist but concurrent COPD + CHF has been little investigated. Design This multicentre survey (SUSPIRIUM) was designed to evaluate: the prevalence of COPD in stable CHF and CHF in stable COPD; diagnostic/therapeutic work-up for concurrent COPD + CHF; clinical profile of patients with COPD + CHF; predictors of COPD in CHF and CHF in COPD. Methods A 5-month-long cross-sectional prospective observational survey was conducted in 10 cardiac and 10 respiratory connected outpatient units...
January 1, 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/28065523/a-web-based-registry-for-familial-hypercholesterolaemia
#20
Kathryn R Napier, Jing Pang, Leanne Lamont, Caroline E Walker, Hugh Js Dawkins, Adam A Hunter, Frank M van Bockxmeer, Gerald F Watts, Matthew I Bellgard
Familial hypercholesterolaemia (FH) is the most common and serious monogenic disorder of lipoprotein metabolism that leads to premature coronary heart disease. Patients with FH are often under-treated, and many remain undiagnosed. The deployment of the FH Australasia Network Registry is a crucial component of the comprehensive model of care for FH, which aims to provide a standardised, high-quality and cost-effective system of care that is likely to have the highest impact on patient outcomes. The FH Australasia Network Registry was customised using a registry framework that is an open source, interoperable system that enables the efficient customisation and deployment of national and international web-based disease registries that can be modified dynamically as registry requirements evolve...
November 30, 2016: Heart, Lung & Circulation
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