Márcia Machado Marinho, Matheus Nunes da Rocha, Emanuel Paula Magalhães, Lyanna Rodrigues Ribeiro, Caio Henrique Alexandre Roberto, Francisco Wagner de Queiroz Almeida-Neto, Marília Lopes Monteiro, João Victor Serra Nunes, Ramon Róseo Paula Pessoa Bezerra de Menezes, Emmanuel Silva Marinho, Pedro de Lima Neto, Alice Maria Costa Martins, Hélcio Silva Dos Santos
This study aims to evaluate the antitrypanosomiasis activity of a synthetic dichloro-substituted aminochalcone via in vitro assays against infected cell cultures, as well as a theoretical characterization of pharmacokinetics and pharmacodynamics against the protein targets of the evolutionary cycle of T. cruzi. The in vitro evaluation of parasite proliferation inhibition was performed via cytotoxicity analysis on mammalian host cells, effect on epimastigote and trypomastigote forms, and cell death analysis, while computer simulations characterized the electronic structure of (2E)-1-(4-aminophenyl)-3-(2,4-dichlorophenyl)prop-2-en-1-one (DCl), the mechanism of action against the proteins of the evolutionary cycle of T...
May 9, 2024: Naunyn-Schmiedeberg's Archives of Pharmacology