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https://www.readbyqxmd.com/read/27096953/kca3-1-channel-inhibition-sensitizes-malignant-gliomas-to-temozolomide-treatment
#1
Giuseppina D'Alessandro, Alfonso Grimaldi, Giuseppina Chece, Alessandra Porzia, Vincenzo Esposito, Antonio Santoro, Maurizio Salvati, Fabrizio Mainiero, Davide Ragozzino, Silvia Di Angelantonio, Heike Wulff, Myriam Catalano, Cristina Limatola
Malignant gliomas are among the most frequent and aggressive cerebral tumors, characterized by high proliferative and invasive indexes. Standard therapy for patients, after surgery and radiotherapy, consists of temozolomide (TMZ), a methylating agent that blocks tumor cell proliferation. Currently, there are no therapies aimed at reducing tumor cell invasion. Ion channels are candidate molecular targets involved in glioma cell migration and infiltration into the brain parenchyma. In this paper we demonstrate that: i) blockade of the calcium-activated potassium channel KCa3...
May 24, 2016: Oncotarget
https://www.readbyqxmd.com/read/14985319/proliferation-of-microglia-but-not-photoreceptors-in-the-outer-nuclear-layer-of-the-rd-1-mouse
#2
Caroline J Zeiss, Elizabeth A Johnson
PURPOSE: To establish whether photoreceptor apoptosis in the rd-1 mouse is accompanied by cell cycle progression. Studies of cell cycle proteins in other models of neuronal death provide consistent evidence that a repertoire of proliferative markers accompanies apoptosis. METHODS: The spatiotemporal progression of photoreceptor loss in rd-1 and control mice at postnatal days (PN)8, -10, -12, -15, and -18 was correlated with markers of G(1)- and S-phase progression...
March 2004: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/12873740/expression-of-cyclins-cyclin-dependent-kinases-and-cyclin-dependent-kinase-inhibitors-in-oligodendrogliomas-in-humans
#3
Valentina Fiano, Chiara Ghimenti, Davide Schiffer
Cyclins are regulatory proteins of the cell cycle which bind and activate kinases. In gliomas, contrary to many malignancies, cyclin D1 is rarely amplified, but together with other cyclins, it increases with anaplasia. In a series of 23 surgical biopsies of grade II and III oligodendroglioma, cyclin D1, E, A, B1, CDK4-6, CDK2, Cdc2 and p27/Kip.1 have been studied by immunohistochemistry and Western blot. Cyclin D1 and A increased with anaplasia, showing a linear correlation with MIB.1 labeling index and an inverse correlation with p27/Kip...
August 21, 2003: Neuroscience Letters
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