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Michael Co, Ava Kwong, Tony Shek
INTRODUCTION: Due to the possibility of underestimation, surgical excision is usually offered to patients with atypical ductal hyperplasia (ADH) diagnosed with core needle biopsy (CNB). Here we review the 10-year data of patients with ADH diagnosed by CNB, aiming to identify the factors associated with under-diagnosis. METHODS: Retrospective review of database from 1st Jan 2005 to 31st Dec 2014 was performed; patients with ADH diagnosed by CNB were identified. Diagnosis upgrade rate and its risk factors were evaluated...
November 13, 2017: International Journal of Surgery
Zhe Li, D Jean Burnell, Russell Jaye Boyd
Cytochrome P450 enzymes were recently engineered to catalyze the C-H amination reaction of aryl sulfonyl azides with excellent regio- and stereoselectivity (Arnold and coworkers JACS, 2014, 136, 15505). The mechanism of this reaction was studied by quantum mechanical (QM)/molecular mechanical (MM) calculations in this work. The C-H activation is found to be a stepwise process consisting of hydrogen abstraction (H-abstraction) of the reactive C-H bond by an iron nitrenoid cofactor to produce the biradical intermediate and the subsequent radical rebinding to form the final product...
November 13, 2017: Journal of Physical Chemistry. B
Christina Kaiser, Christina Kehrer, Mignon-Denise Keyver-Paik, Thomas Hecking, Tiyasha Hosne Ayub, Claudia Leutner, Hans Schild, Walther Kuhn
Background A published retrospective data of our study group demonstrated that premenopausal women, patients with lobular invasive breast cancer or patients with high breast density [American College of Radiology (ACR) classification 3+4] significantly benefit from magnetic resonance imaging (MRI) leading to additional detection of malignant foci of 20.2% in the index and 2.5% in the contralateral breast, which would otherwise not be detected by routine imaging. Critics of preoperative MRI focus on higher false-positive rates leading to unnecessary surgical procedures and mastectomies...
November 11, 2017: Hormone Molecular Biology and Clinical Investigation
Stephanie A Valenzuela, Alondra J Cortes, Zakery J E Tippins, Morgan H Daly, Terell E Keel, Benjamin F Gherman, John D Spence
A combined computational and experimental study was conducted to examine the effect of extended benzannelation orientation on C(1)-C(5) and C(1)-C(6) cyclization of acyclic quinoxalenediynes. Calculations (mPW1PW91/cc-pVTZ // mPW1PW91/6-31G(d,p)) on terminal and phenylethynyl-substituted 5,6-diethynylquinoxaline and 6,7-diethynylquinoxaline showed C1-C6 Bergman cyclization as the favored thermodynamic reaction pathway, with larger C(1)-C(6) preference for the angular quinoxalenediynes due to gain of a new aromatic sextet...
November 9, 2017: Journal of Organic Chemistry
Rivkah Tamar Rogawski, Ivan V Sergeyev, Yinglu Zhang, Timothy Hoang Tran, Yongjun Li, Liang Tong, Ann E McDermott
We characterize the effect of specifically bound biradicals on the NMR spectra of dihydrofolate reductase (DHFR) from E. coli. Dynamic nuclear polarization methods enhance the signal-to-noise of solid state NMR experiments by transferring polarization from unpaired electrons of biradicals to nuclei. There has been recent interest in co-localizing the paramagnetic polarizing agents with the analyte of interest through covalent or non-covalent specific interactions. This experimental approach broadens the scope of dynamic nuclear polarization methods by offering the possibility of selective signal enhancements and the potential to work in a broad range of environments...
November 8, 2017: Journal of Physical Chemistry. B
Dominique J P van Uden, J Hans W de Wilt, Carla Meeuwis, Charlotte F J M Blanken-Peeters, Ritse M Mann
BACKGROUND: The aim of this study was to describe the dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) features of inflammatory breast cancer (IBC) and to assess the value of DCE-MRI for the prediction of pathological complete response (pCR). METHODS: Image analysis was performed in 15 patients with IBC (cT4d) and 12 patients with non-IBC (cT2), and included the assessment of BIRADS characteristics, skin alterations, enhancement characteristics, and changes post chemotherapy...
September 2017: Breast Care
Tim Seung Chung, Jin H Park, Miguel A Garcia-Garibay
Taking advantage of an operationally simple technique to perform transmission pump-probe spectroscopy in crystalline solids, based on the use nanocrystalline suspensions in water, we analyzed the intermediates in the photodenitrogenation of a Δ2-1,2,3-triazoline bearing a benzophenone group that served as an internal triplet sensitizer. Measurements carried out in acetonitrile solution revealed the formation of a transient with a λmax= 570 nm with a lifetime of 70 ns. Measurements in the solid state displayed an analogous blue shifted transient with a λmax= 510 nm that first grows and then decays with time constants of 63 ns and 270 ns, respectively...
October 20, 2017: Journal of Organic Chemistry
Irene Ruggirello, Jacopo Nori, Isacco Desideri, Calogero Saieva, Elisabetta Giannotti, Giulia Bicchierai, Diego De Benedetto, Giulio Francolini, Simonetta Bianchi, Vania Vezzosi, Luis Sanchez, Tommaso Susini, Lorenzo Orzalesi, Icro Meattini, Lorenzo Livi, Vittorio Miele
PURPOSE: The 11-gauge (11G) stereotactic vacuum-assisted breast biopsy (VABB) showed a better profile than 14G-VABB in terms of feasibility, safety, microcalcification sampling, and accuracy. Underestimation rates were significantly lower with 11G-VABB than with 14G-VABB. Thus, the introduction of an even larger needle at the VABB procedure could reduce this rate further. The purpose of this study was to compare the overall performance of stereotactic VABB with 8G and 11G needles. MATERIALS AND METHODS: Four hundred and three VABBs performed between July 2012 and February 2015 at the Breast Diagnostic Unit of Careggi Hospital in Florence were retrospectively analyzed; 197 were performed with 11G-VABB and 206 with 8G-VABB...
October 6, 2017: European Journal of Surgical Oncology
Gloria Zhang, Dana Ataya, Paulette L Lebda, Benjamin C Calhoun
Mucocele-like lesions of the breast diagnosed on core biopsy are usually excised to exclude the possibility of partial sampling of an invasive mucinous carcinoma. The goal of this study was to correlate the pathologic and radiologic features of mucocele-like lesions to determine if excision is mandatory. Over a 16 year period we identified 32 patients with mucocele-like lesions diagnosed on 27 (84%) stereotactic and 5 (16%) ultrasound-guided core biopsies. The indications for core biopsy were: calcifications in 24 (75%), a mass in 7 (22%), and a mass with calcifications in 1 (3%)...
October 11, 2017: Breast Journal
Gérard Audran, Elena G Bagryanskaya, Paul Brémond, Mariya V Edeleva, Sylvain R A Marque, Dmitriy A Parkhomenko, Olga Yu Rogozhnikova, Victor M Tormyshev, Evgeny V Tretyakov, Dmitry V Trukhin, Svetlana I Zhivetyeva
Recently, new applications of trityl-nitroxide biradicals were proposed. In the present study, attachment of a trityl radical to alkoxyamines was performed for the first time. The rate constants kd of C-ON bond homolysis in these alkoxyamines were measured and found to be equal to those for alkoxyamines without trityl. The electron paramagnetic resonance (EPR) spectra of the products of alkoxyamine homolysis (trityl-TEMPO and trityl-SG1 biradicals) were recorded, and the corresponding exchange interactions were estimated...
November 14, 2016: Polymer Chemistry
Juliana M R B Mello, Fernando P Bittelbrunn, Marcio A B C Rockenbach, Guilherme G May, Leonardo M Vedolin, Marilia S Kruger, Matheus D Soldatelli, Guilherme Zwetsch, Gabriel T F de Miranda, Saone I P Teixeira, Bruna S Arruda
OBJECTIVES: To evaluate the quality assurance of mammography results at a reference institution for the diagnosis and treatment of breast cancer in southern Brazil, based on the BIRADS (Breast Imaging Reporting and Data System) 5th edition recommendations for auditing purposes. MATERIALS AND METHODS: Retrospective cohort and cross-sectional study with 4502 patients (9668 mammographies)) who underwent at least one or both breast mammographies throughout 2013 at a regional public hospital, linked to a federal public university...
October 4, 2017: Insights Into Imaging
Martin L Kirk, David A Shultz, Jinyuan Zhang, Ranjana Dangi, Laura Ingersol, Jing Yang, Nathaniel S Finney, Roger D Sommer, Lukasz Wojtas
The correlation of electron transfer with molecular conductance (g: electron transport through single molecules) by Nitzan and others has contributed to a fundamental understanding of single-molecule electronic materials. When an unsymmetric, dipolar molecule spans two electrodes, the possibility exists for different conductance values at equal, but opposite electrode biases. In the device configuration, these molecules serve as rectifiers of the current and the efficiency of the device is given by the rectification ratio (RR = gforward/greverse)...
August 1, 2017: Chemical Science
Joish Upendra Kumar, Vivek Sreekanth, Harikiran R Reddy, Aishwarya B Sridhar, Niveditha Kodali, Anitha S Prabhu
INTRODUCTION: Breast cancer incidence and related mortality is increasing in Indian women. Indian ladies hesitate to seek medical care for breast related issues. Screening mammography, proved to effectively reduce mortality, has been deemed not feasible in Indian context due to cost considerations. The suggested alternatives have not been proven to improve mortality rates. AIM: To find the relevance of screening mammography camp among Indian women. MATERIALS AND METHODS: A week long screening mammography camp was organized in a tertiary care hospital...
August 2017: Journal of Clinical and Diagnostic Research: JCDR
Akihito Konishi, Yui Okada, Motohiro Nakano, Kenji Sugisaki, Kazunobu Sato, Takeji Takui, Makoto Yasuda
Mesityl derivatives of the unknown dibenzopentalene isomer dibenzo[a,f]pentalene were synthesized. The molecular geometry and physical properties of dibenzo[a,f]pentalene were investigated. Dibenzo[a,f]pentalene combines a large antiaromatic and appreciable singlet open-shell character, properties not shared by well-known isomer dibenzo[a,e]pentalene.
October 10, 2017: Journal of the American Chemical Society
Olubukola At Omidiji, Princess C Campbell, Nicholas K Irurhe, Omolola M Atalabi, Oluyemisi O Toyobo
BACKGROUND: Breast cancer is the commonest female cancer in Nigeria. Despite its increased awareness, affordability of available screening tools is a bane. Mammography, the goal standard for screening is costly and not widely available in terms of infrastructure, technical/personnel capabilities. Ultrasound is accessible and affordable. OBJECTIVES: This study compared the use of ultrasound and mammography as breast cancer screening tools in women in South West Nigeria by characterizing and comparing the prevalent breast parenchyma, breast cancer features and the independent sensitivity of ultrasound and mammography...
March 2017: Ghana Medical Journal
D Demchig, C Mello-Thoms, Kh Khulan, A Ramish, P C Brennan
Objective: Mammographic density (MD) is a significant risk factor for breast cancer and an important determinant for establishing efficiency of any screening program. Currently, the distribution and influential factors of MD is unknown among Mongolian women. This work aims to characterize MD of Mongolian women. Methods: The ethical approval was obtained from Research Ethics Board of the University of Sydney (2014/973) and National Ethic Committee from Ministry of Mongolia (2015/04). We recruited 1985 women aged 16-83 from the National Cancer Center in Mongolia for whom MD and age of each woman was known...
September 27, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
Tharushi A Perera, Eric W Reinheimer, Todd W Hudnall
The discovery of thermal and photochemical control by Woodward and Hoffmann revolutionized how we understand chemical reactivity. Similarly, we now describe the first example of a carbene that exhibits differing thermal and photochemical reactivity. When a singlet ground-state N,N'-diamidocarbene 1 was photolyzed at 380 nm, excitation to a triplet state was observed. The triplet-state electronic structure was characteristic of the expected biradical σ(1)pπ(1) spin configuration according to a combination of spectroscopic and computational methods...
October 4, 2017: Journal of the American Chemical Society
Gavin O Jones, Zachary J Krebs
Thorough computational studies were performed on mechanisms and energies for the thermal trimerizations of neutral or electron-rich acetylenes used as cross-linkers in organic hard-masks for lithography applications. These studies indicate that the operative mechanism proceeds through initial cyclobutadiene formation via a biradical mechanism. Cyclobutadienes form Dewar benzenes via Diels-Alder cycloadditions, or biradical processes, or both, before producing benzenes by electrocyclic ring-opening reactions...
October 11, 2017: Organic & Biomolecular Chemistry
Ioannis K Papapanagiotou, Dimitra Koulocheri, Vasileios Kalles, Paraskevi Liakou, Nikolaos V Michalopoulos, Wasim Al-Harethee, Georgia Georgiou, Maria Matiatou, Afroditi Nonni, Anastasia Pazaiti, Georgios E Theodoropoulos, Evangelos Menenakos, Georgios C Zografos
BACKGROUND: The Breast Lesion Excision System(®) (BLES(®)) is a stereotactic vacuum-assisted breast biopsy device that utilizes radiofrequency in order to excise non-palpable mammographic lesions for pathologic diagnosis. The purpose of this study was to evaluate the efficacy of BLES(®) in performing complete, margin-free excisions of small solid carcinomas. METHODS: Our retrospective study of prospectively enrolled patients included 50 cases of non-palpable, BIRADS ≥ 4, solid by means of mammography and sonography, lesions...
September 16, 2017: Breast Cancer: the Journal of the Japanese Breast Cancer Society
Joshua E Barker, Conerd K Frederickson, Michael H Jones, Lev N Zakharov, Michael M Haley
The synthesis and optoelectronic properties of 24 π-electron, formally antiaromatic fluoreno[3,2-b]fluorene and fluoreno[4,3-c]fluorene (FF), are presented. The solid-state structure of [4,3-c]FF along with computationally analogous molecules shows that the outer rings are aromatic while the central four rings possess a bond-localized 2,6-naphthoquinodimethane motif. The antiaromaticity and biradical character of the FFs is assessed computationally, the results of which indicate the dominance of the closed-shell ground state for these molecules...
October 6, 2017: Organic Letters
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