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Charles Penner
"It was the best of times, it was the worst of times, it was the age of wisdom, it was the age of foolishness, it was the epoch of belief, it was the epoch of incredulity." The opening line of Dickens's A Tale of Two Cities could easily be the dramatic opening line of a summary of the establishment of a satellite medical school campus in Manitoba. Reflection on my last four years as associate dean reveals that most of the descriptors in that famous sentence at one time or another were apropos. This brief essay will relate the experiences of the last four years and some of the lessons learned along the way...
February 16, 2018: Medical Teacher
Asbjørn Årøen, Brian M Devitt
No abstract text is available yet for this article.
April 2018: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
Cecile Magis-Escurra, Richard M Anthony, Adri G M van der Zanden, Dick van Soolingen, Jan-Willem C Alffenaar
No abstract text is available yet for this article.
April 2018: Lancet Respiratory Medicine
John G O'Grady
No abstract text is available yet for this article.
May 2018: Journal of Hepatology
Eva-Maria Niehaus, Hee-Kyoung Kim, Martin Münsterkötter, Slavica Janevska, Birgit Arndt, Svetlana A Kalinina, Petra M Houterman, Il-Pyung Ahn, Ilaria Alberti, Stefano Tonti, Da-Woon Kim, Christian M K Sieber, Hans-Ulrich Humpf, Sung-Hwan Yun, Ulrich Güldener, Bettina Tudzynski
Fusarium fujikuroi causes bakanae ("foolish seedling") disease of rice which is characterized by hyper-elongation of seedlings resulting from production of gibberellic acids (GAs) by the fungus. This plant pathogen is also known for production of harmful mycotoxins, such as fusarins, fusaric acid, apicidin F and beauvericin. Recently, we generated the first de novo genome sequence of F. fujikuroi strain IMI 58289 combined with extensive transcriptional, epigenetic, proteomic and chemical product analyses. GA production was shown to provide a selective advantage during infection of the preferred host plant rice...
October 2017: PLoS Pathogens
(no author information available yet)
No abstract text is available yet for this article.
April 2017: Journal of the California Dental Association
Min Chen, Georges Grinstein, Chris R Johnson, Jessie Kennedy, Melanie Tory
There is little doubt that having a theoretic foundation will benefit the field of visualization, including its main subfields. Because there has been a substantial amount of work on taxonomies and conceptual models in the visualization literature and some recent work on theoretic frameworks, such a theoretic foundation is not a foolish or impractical ambition. This article asks, "How can we build a theoretic foundation for visualization collectively as a community?" The authors envision the pathways for four different aspects of a theoretic foundation: taxonomies and ontologies, principles and guidelines, conceptual models and theoretic frameworks, and quantitative laws and theoretic systems...
2017: IEEE Computer Graphics and Applications
R Nourse, P Adamshick, J Stoltzfus
OBJECTIVE: Binge drinking is a significant public health problem across college campuses in the United States. Despite substantial research and the use of evidence-based methods, the binge drinking culture remains an obstinate health crisis on campuses. This study examined the current binge drinking rate on a selected college campus, the association between binge drinking and anxiety and depression as well as the associated consequences of students' alcohol use. METHODS: A sample of 201 students from a small, private Mid-Atlantic college completed validated scales as well as demographics and questionnaires...
March 2017: East Asian Archives of Psychiatry: Official Journal of the Hong Kong College of Psychiatrists
Charles K Turner
The mainstream theories and models of the physical sciences, including neuroscience, are all consistent with the principle of causality. Wholly causal explanations make sense of how things go, but are inherently value-neutral, providing no objective basis for true beliefs being better than false beliefs, nor for it being better to intend wisely than foolishly. Dennett (1987) makes a related point in calling the brain a syntactic (procedure-based) engine. He says that you cannot get to a semantic (meaning-based) engine from there...
2017: Frontiers in Psychology
Emily Freeman
Prevalence of HIV after age 50 is considerable, especially in southern Africa. Negative social constructions of HIV in older age, and the health consequences of ageing with the virus, mean that having HIV presents a challenge for many people's roles and social memberships, threatening to disrupt their sense of self. Using constructivist grounded theory and qualitative data from rural Malawi, this paper describes how older men and women deal with these identity challenges. Drawing on a symbolic interactionist framework, it uses identity control theory to explore how the study's participants presented their post-diagnosis behaviours in ways that maintained their most significant pre-diagnosis identities as 'adults', a label they gave to the core identity of being a person who belongs in the social world...
December 24, 2016: Sociology of Health & Illness
Jos L T Blank, Bart L van Hulst, Vivian G Valdmanis
In this paper, we address the issue of whether it is economically advantageous to concentrate emergency rooms (ERs) in large hospitals. Besides identifying economies of scale of ERs, we also focus on chain economies. The latter term refers to the effects on a hospital's costs of ER patients who also need follow-up inpatient or outpatient hospital care. We show that, for each service examined, product-specific economies of scale prevail indicating that it would be beneficial for hospitals to increase ER services...
November 2017: Health Economics
James L Wofford, Melanie J Martin, Claudia L Campos
No abstract text is available yet for this article.
November 1, 2016: JAMA Internal Medicine
Milton Packer
New heart failure guidelines have been issued during the past several months, both in the United States and in Europe, in response to recent advances in and the approval of new drugs for the treatment of heart failure. Although guidelines documents are often viewed as authoritative and purely evidence-based, there are replete with meaningful (and inexplicable) inconsistencies, which derive from a review of the same body of scientific data by different groups. This satirical review highlights several examples of the entertaining foolishness of recent guideline documents in the good-natured hope that physicians will understand what the guidelines are, and more importantly, what they are not...
September 2016: Journal of Cardiac Failure
D Page, S Crymble, K Lawday, M Long, J Stoffman, L Waterhouse, P Wilton
INTRODUCTION: A network of 25 haemophilia/inherited bleeding disorder comprehensive care centres was established in Canada in the 1970s and 1980s. In 2007, standards of care, focused on the structural and resource requirements necessary to effectively provide optimal care, were adopted. AIM: Assess how human and physical resources affect centres' capacity to attain standards of care. METHODS: The Canadian Hemophilia Society (CHS), with the support of the Association of Hemophilia Clinic Directors of Canada (AHCDC), undertook the assessment...
July 2016: Haemophilia: the Official Journal of the World Federation of Hemophilia
V Sri Nagesh
The ultimate dream of every young student stepping into the hallowed portals of a medical college is to achieve the holy grail of medical education, a DM seat. However, the real battle begins only after the DM seat is won. The residency is a veritable roller coaster ride all through the three years, with the student alternating between exhilaration and despondency, wisdom and foolishness, hope and despair and ecstasy and agony. The long working hours, logistic difficulties, interpersonal conflicts and resource limitations are the anvils on which the callow postgraduates are beaten into shape, to bring to fore, their inner steel...
January 2016: Indian Journal of Endocrinology and Metabolism
Madiha Khan, Laura Ragni, Paul Tabb, Brenda C Salasini, Steven Chatfield, Raju Datla, John Lock, Xiahezi Kuai, Charles Després, Marcel Proveniers, Cao Yongguo, Daoquan Xiang, Halima Morin, Jean-Pierre Rullière, Sylvie Citerne, Shelley R Hepworth, Véronique Pautot
In the model plant Arabidopsis (Arabidopsis thaliana), endogenous and environmental signals acting on the shoot apical meristem cause acquisition of inflorescence meristem fate. This results in changed patterns of aerial development seen as the transition from making leaves to the production of flowers separated by elongated internodes. Two related BEL1-like homeobox genes, PENNYWISE (PNY) and POUND-FOOLISH (PNF), fulfill this transition. Loss of function of these genes impairs stem cell maintenance and blocks internode elongation and flowering...
November 2015: Plant Physiology
George Leslie Hicks
No abstract text is available yet for this article.
November 2015: Journal of Thoracic and Cardiovascular Surgery
Garry Dossey
During the past twenty years a digital sea change has affected our world. Digital devices have changed the way we live and especially the way we work in our professions. As dentists, we are able to work with far greater accuracy and precision than ever before; we would be foolish not to embrace these advances. But, as is often the case with rapid cultural changes, we need to be aware of the possibility of unintended consequences that may accompany this revolution. Sound scientific studies are beginning to warn of the psychological and physiological problems of overuse of digital devices in our daily lives...
April 2015: Texas Dental Journal
David Jolley
Dementia has been recognised as a major challenge to health, social care and economies. Research by Rubinsztein and colleagues, in this issue, has compared the services provided by memory clinics with those of traditional community mental health team services. They conclude that memory clinics offer a more comprehensive and multidisciplinary service at no extra cost. Here I will question some of their findings and highlight the importance of better continuity of care between primary and secondary services.
February 2015: BJPsych Bulletin
Gerald Cochran, Craig Field, Michael Foreman, Thomas Ylioja, Carlos V R Brown
Alcohol-related injuries are a major source of admission for trauma care. Screening and brief intervention (SBI) for injured patients can result in decreased drinking and risk behaviors. It is not clear SBI is equally beneficial for all injured patients. A secondary data analysis of 553 patients admitted to two Level-1 trauma centers was conducted. Latent class analysis was used to identify patient subgroups based on injury-related risks and consequences of alcohol use. Intervention effects on drinking were examined among subgroups...
June 2016: Injury Prevention: Journal of the International Society for Child and Adolescent Injury Prevention
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