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Leslie G Branch, Clayton Crantford, Teresa Cunningham, Gaurav Bharti, James Thompson, Dan Couture, Lisa R David
BACKGROUND: Resorbable plating in cranial reconstruction for craniosynostosis has fewer reported complications than rigid hardware. Few long-term outcome studies exist for pediatric patients treated with this technology for cranial vault reconstruction. METHODS: A retrospective review was performed on pediatric patients undergoing cranial vault reconstruction for craniosynostosis by 3 surgeons over a 15-year period. MacroPore (Cytori Therapeutics, San Diego, CA) or Lactosorb (Walter Lorenz Surgical Inc, Jacksonville, FL), composed of polyglycolic and polylactic acids, was used for resorbable plate fixation...
January 2017: Journal of Craniofacial Surgery
Joel A Aronowitz, Ryan A Lockhart, Cloe S Hakakian, Zoe E Birnbaum
INTRODUCTION: With stromal vascular fraction (SVF) cell and adipose-derived stem cell-based technologies translating into the clinical setting, numerous isolation systems have been developed for the point of care isolation of SVF cells from adipose tissue. A relative lack of performance data on these systems can make objective assessment difficult for prospective clinicians. This study compared the performance of 4 SVF cell isolation systems. METHODS: Four isolation systems were compared: the MultiStation by PNC International, the LipoKit by MediKhan, the GID SVF-2 platform by GID Europe Ltd, and the StemSource 900/MB system by Cytori Therapeutics, Inc...
September 2016: Annals of Plastic Surgery
Timothy D Henry, Carl J Pepine, Charles R Lambert, Jay H Traverse, Richard Schatz, Marco Costa, Thomas J Povsic, R David Anderson, James T Willerson, Steven Kesten, Emerson C Perin
OBJECTIVE: To assess safety and feasibility of autologous adipose-derived regenerative cells (ADRCs), for treatment of chronic ischemic cardiomyopathy patients. BACKGROUND: Preclinical and early clinical trials suggest ADRCs have excellent potential for ischemic conditions. METHODS: The Athena program consisted of two parallel, prospective, randomized (2:1, active: placebo), double-blind trials assessing intramyocardial (IM) ADRC delivery [40-million, n = 28 (ATHENA) and 80-million (ATHENA II) cells, n = 3])...
February 1, 2017: Catheterization and Cardiovascular Interventions
Pietro Gentile, Maria Giovanna Scioli, Augusto Orlandi, Valerio Cervelli
BACKGROUND: Actually, there are 2 main methods to obtain stromal vascular fraction (SVF): enzymatic digestion and mechanical filtration; however, the available systems report heterogeneous and sometimes not univocal results. The aim of this study is to evaluate different procedures for SVF isolation and compare their clinical efficacy in the treatment of soft-tissue defects in plastic and reconstructive surgery. The authors evaluated Celution and Medikhan, enzymatic systems, and Fatstem and Mystem system, mechanical separation systems...
June 2015: Plastic and Reconstructive Surgery. Global Open
Rossana Domenis, Lara Lazzaro, Sarah Calabrese, Damiano Mangoni, Annarita Gallelli, Evgenia Bourkoula, Ivana Manini, Natascha Bergamin, Barbara Toffoletto, Carlo A Beltrami, Antonio P Beltrami, Daniela Cesselli, Pier Camillo Parodi
INTRODUCTION: Autologous fat grafting is commonly used to correct soft-tissue contour deformities. However, results are impaired by a variable and unpredictable resorption rate. Autologous adipose-derived stromal cells in combination with lipoinjection (cell-assisted lipotransfer) seem to favor a long-term persistence of fat grafts, thus fostering the development of devices to be used in the operating room at the point of care, to isolate the stromal vascular fraction (SVF) and produce SVF-enhanced fat grafts with safe and standardized protocols...
January 5, 2015: Stem Cell Research & Therapy
Ondrej Mestak, Andrej Sukop, Yu-Sheng Hsueh, Martin Molitor, Jan Mestak, Jana Matejovska, Lucie Zarubova
BACKGROUND: Breast-conserving treatment (BCT) leads to a progressive and deteriorating breast deformity. Fatgrafting is ideal for breast reconstruction after BCT. The most frequently utilized technique for fat processing is centrifugation. The PureGraft device (Cytori Therapeutics, San Diego, CA, USA) is a new method that involves washing and filtering the fat to prepare the graft. We compared the subjective and objective outcomes of two fat-processing methods, centrifugation and PureGraft filtration...
2014: World Journal of Surgical Oncology
Joel A Aronowitz, Joshua D I Ellenhorn
BACKGROUND: Supplementation of fat grafts with stromal vascular fraction cells is an emerging technique used to improve graft reliability. A variety of systems for isolating stromal vascular fraction cells are commercially available. The lack of performance data obtained operating the systems in a standardized environment prevents objective assessment of performance. This prospective, blinded study compared performance of four commercially available stromal vascular fraction isolation systems when operated in a clinical outpatient surgery environment...
December 2013: Plastic and Reconstructive Surgery
Natsuko Kakudo, Yoshihito Tanaka, Naoki Morimoto, Takeshi Ogawa, Satoshi Kushida, Tomoya Hara, Kenji Kusumoto
BACKGROUND: To overcome the absorption of traditional fat grafting, techniques for adipose-derived regenerative cell (ADRC)-enriched fat grafting are currently being adapted for practical application. The Celution800/CRS (Cytori Therapeutics, San Diego, CA) has enabled rapid grafting of the patient's own freshly harvested ADRCs without requiring a culturing step. However, the optimal cell concentration and the effects of ADRCs on the characteristics of grafted fat after free fat grafting remain unclear...
October 10, 2013: Journal of Translational Medicine
Hilkka H Peltoniemi, Asko Salmi, Susanna Miettinen, Bettina Mannerström, Kai Saariniemi, Raija Mikkonen, Hannu Kuokkanen, Christian Herold
BACKGROUND: Stem cell enrichment is generally believed to be of crucial importance for success in lipofilling for cosmetic breast augmentation. No comparative clinical studies have been reported to support this. METHODS: A total of 18 women underwent breast augmentation with water-assisted lipotransfer (WAL). In 10 of the cases, transferred lipoaspirate was enriched with stromal stem cells using the Celution(®) system (Cytori Therapeutics Inc., San Diego, Ca, USA)...
November 2013: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
Mark E Schafer, Kevin C Hicok, Daniel C Mills, Steve R Cohen, James J Chao
BACKGROUND: Although clinical evidence of successful autologous fat transfer (AFT) using third-generation ultrasound-assisted liposuction (UAL) is readily available, no study has quantified adipocyte viability using standardized methods. OBJECTIVES: The authors assess acute adipocyte viability following fat aspiration as a first step in determining the overall efficacy of using third-generation UAL for AFT. METHODS: Lipoaspirate samples were collected from patients who underwent elective liposuction procedures at multiple surgery centers...
July 2013: Aesthetic Surgery Journal
Min Zhu, Steven R Cohen, Kevin C Hicok, Rob K Shanahan, Brian M Strem, Johnson C Yu, Douglas M Arm, John K Fraser
BACKGROUND: Successful long-term volume retention of an autologous fat graft is problematic. The presence of contaminating cells, tumescent fluid, and free lipid in the graft contributes to disparate outcomes. Better preparation methods for the fat graft before transplantation may significantly improve results. METHODS: Subcutaneous fat from 22 donors was divided and processed using various graft preparation methods: (1) no manipulation control, (2) gravity separation, (3) Coleman centrifugation, and (4) simultaneous washing with filtration using a commercially available system (Puregraft; Cytori Therapeutics, Inc...
April 2013: Plastic and Reconstructive Surgery
Kevin C Hicok, Marc H Hedrick
The popularity of nonhematopoietic, adult tissue-derived stem and progenitor cells for use as a cellular research tool, and ultimately as a clinical therapeutic, has increased exponentially over the past decade. Almost all adult-derived stem/progenitor cells (autologous and allogeneic), with one exception, require at least some ex vivo expansion or further manipulation prior to use to satisfy efficacy and safety requirements for preclinical or clinical use. The principal reason is the relatively low frequency of these therapeutically valuable cells within any given adult tissue, except for adipose tissue, which has been shown to have at least two log greater concentrations of these progenitor cells...
2011: Methods in Molecular Biology
K Lin, Y Matsubara, Y Masuda, K Togashi, T Ohno, T Tamura, Y Toyoshima, K Sugimachi, M Toyoda, H Marc, A Douglas
BACKGROUND: The therapeutic potential of using stem cells is tremendous. Mesenchymal stromal cells (MSC) have now been isolated in various tissues including bone marrow (BM), muscle, skin and adipose tissue. Among them, adipose tissue could be one of the most suitable cell sources for cell therapy, because of its easy accessibility, minimal morbidity and abundance of stem cells. The large numbers of stem cells in adipose tissue means that clinically relevant stem cell numbers could be extracted from the tissue, potentially eliminating the need for in vitro expansion...
2008: Cytotherapy
Eric Daniels
Cytori Therapeutics, Inc. develops stem and regenerative cell therapies that can be used in a 'real-time' treatment setting for cardiovascular disease, reconstructive surgery and many other serious, chronic and life-threatening conditions and disorders. Cytori uses adult stem cells from adipose tissue, which offers a rich, accessible and autologous source of adult stem cells, and maximizes these benefits to create a cost-effective and safe treatment option.
May 2007: Regenerative Medicine
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