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https://www.readbyqxmd.com/read/28214126/pulmonary-nodules-in-african-migrants-caused-by-chronic-schistosomiasis
#1
REVIEW
Federico Gobbi, Dora Buonfrate, Andrea Angheben, Anna Beltrame, Matteo Bassetti, Luca Bertolaccini, Giuseppe Bogina, Simone Caia, Silvia Duranti, Maria Gobbo, Valentina Marchese, Stefania Marocco, Maria Merelli, Geraldo Monteiro, Alberto Terzi, Zeno Bisoffi
Schistosomiasis is a neglected tropical disease that can cause mainly hepatic and genitourinary damage, depending on the species. Involvement of the lungs has been commonly described in acute infection (Katayama syndrome) and chronic infection (pulmonary hypertension). Although rarely reported in the scientific literature, cases of lung nodules due to chronic schistosome infection are also possible and are probably more frequent than commonly thought. Here we report seven cases of African migrants who were diagnosed with chronic schistosomiasis and pulmonary nodules due to deposition of schistosome eggs, and we compare our findings to the case reports found in the scientific literature...
February 14, 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/28212398/modelling-the-risk-of-taenia-solium-exposure-from-pork-produced-in-western-kenya
#2
Lian F Thomas, William A de Glanville, Elizabeth A J Cook, Barend M De C Bronsvoort, Ian Handel, Claire N Wamae, Samuel Kariuki, Eric M Fèvre
The tapeworm Taenia solium is the parasite responsible for neurocysticercosis, a neglected tropical disease of public health importance, thought to cause approximately 1/3 of epilepsy cases across endemic regions. The consumption of undercooked infected pork perpetuates the parasite's life-cycle through the establishment of adult tapeworm infections in the community. Reducing the risk associated with pork consumption in the developing world is therefore a public health priority. The aim of this study was to estimate the risk of any one pork meal in western Kenya containing a potentially infective T...
February 17, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28207792/partnering-for-impact-integrated-transmission-assessment-surveys-for-lymphatic-filariasis-soil-transmitted-helminths-and-malaria-in-haiti
#3
Alaine Kathryn Knipes, Jean Frantz Lemoine, Franck Monestime, Carl R Fayette, Abdel N Direny, Luccene Desir, Valery E Beau de Rochars, Thomas G Streit, Kristen Renneker, Brian K Chu, Michelle A Chang, Kimberly E Mace, Kimberly Y Won, Patrick J Lammie
BACKGROUND: Since 2001, Haiti's National Program for the Elimination of Lymphatic Filariasis (NPELF) has worked to reduce the transmission of LF through annual mass drug administration with diethylcarbamazine and albendazole. The NPELF reached full national coverage with MDA for LF in 2012, and by 2014, a total of 14 evaluation units (48 communes) had met WHO eligibility criteria to conduct LF transmission assessment surveys (TAS) to determine whether prevalence had been reduced to below a threshold, such that transmission is assumed to be no longer sustainable...
February 16, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28199329/correction-mlst-based-population-genetic-analysis-in-a-global-context-reveals-clonality-amongst-cryptococcus-neoformans-var-grubii-vni-isolates-from-hiv-patients-in-southeastern-brazil
#4
(no author information available yet)
[This corrects the article DOI: 10.1371/journal.pntd.0005223.].
February 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28192438/advances-in-neglected-tropical-disease-vaccines-developing-relative-potency-and-functional-assays-for-the-na-gst-1-alhydrogel-hookworm-vaccine
#5
Jill B Brelsford, Jordan L Plieskatt, Anna Yakovleva, Amar Jariwala, Brian P Keegan, Jin Peng, Pengjun Xia, Guangzhao Li, Doreen Campbell, Maria Victoria Periago, Rodrigo Correa-Oliveira, Maria Elena Bottazzi, Peter J Hotez, David Diemert, Jeffrey M Bethony
A new generation of vaccines for the neglected tropical diseases (NTDs) have now advanced into clinical development, with the Na-GST-1/Alhydrogel Hookworm Vaccine already being tested in Phase 1 studies in healthy adults. The current manuscript focuses on the often overlooked critical aspects of NTD vaccine product development, more specifically, vaccine stability testing programs. A key measure of vaccine stability testing is "relative potency" or the immunogenicity of the vaccine during storage. As with most NTD vaccines, the Na-GST-1/Alhydrogel Hookworm Vaccine was not developed by attenuation or inactivation of the pathogen (Necator americanus), so conventional methods for measuring relative potency are not relevant for this investigational product...
February 13, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28192064/aedes-borne-virus-mosquito-interactions-mass-spectrometry-strategies-and-findings
#6
Victoria Pando-Robles, Cesar V Batista
Aedes-borne viruses are responsible for high-impact neglected tropical diseases and unpredictable outbreaks such as the ongoing Zika epidemics. Aedes mosquitoes spread different arboviruses such as Dengue virus (DENV), Chikungunya virus (CHIKV), and Zika virus, among others, and are responsible for the continuous emergence and reemergence of these pathogens. These viruses have complex transmission cycles that include two hosts, namely the Aedes mosquito as a vector and susceptible vertebrate hosts. Human infection with arboviruses causes diseases that range from subclinical or mild to febrile diseases, encephalitis, and hemorrhagic fever...
February 13, 2017: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/28187129/podoconiosis-trachomatous-trichiasis-and-cataract-in-northern-ethiopia-a-comparative-cross-sectional-study
#7
Helen Burn, Sintayehu Aweke, Tariku Wondie, Esmael Habtamu, Kebede Deribe, Saul Rajak, Stephen Bremner, Gail Davey
BACKGROUND: Rural populations in low-income countries commonly suffer from the co-morbidity of neglected tropical diseases (NTDs). Podoconiosis, trachomatous trichiasis (both NTDs) and cataract are common causes of morbidity among subsistence farmers in the highlands of northern Ethiopia. We explored whether podoconiosis was associated with cataract or trachomatous trichiasis (TT) among this population. METHODS: A comparative cross-sectional study was conducted in East Gojam region, Amhara, Ethiopia in May 2016...
February 10, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28185724/simplifying-nature-towards-the-design-of-broad-spectrum-kinetoplastid-inhibitors-inspired-by-acetogenins
#8
Eoin R Gould, Elizabeth F B King, Stefanie K Menzies, Andrew L Fraser, Lindsay B Tulloch, Marija K Zacharova, Terry K Smith, Gordon J Florence
The need for new treatments for the neglected tropical diseases African sleeping sickness, Chagas disease and Leishmaniasis remains urgent with the diseases widespread in tropical regions, affecting the world's very poorest. We have previously reported bis-tetrahydropyran 1,4-triazole analogues designed as mimics of the annonaceous acetogenin natural product chamuvarinin, which maintained trypanocidal activity. Building upon these studies, we here report related triazole compounds with pendant heterocycles, mimicking the original butenolide of the natural product...
January 28, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28182664/improving-our-forecasts-for-trachoma-elimination-what-else-do-we-need-to-know
#9
Amy Pinsent, Manoj Gambhir
The World Health Organization (WHO) has targeted trachoma for elimination as a public health concern by 2020. Mathematical modelling is used for a range of infectious diseases to assess the impact of different intervention strategies on the prevalence of infection or disease. Here we evaluate the performance of four different mechanistic mathematical models that could all realistically represent trachoma transmission. We fit the four different mechanistic models of trachoma transmission to cross-sectional age-specific Polymerase Chain Reaction (PCR) and Trachomatous inflammation, follicular (TF) prevalence data...
February 9, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28179407/calprotectin-as-a-biomarker-for-melioidosis-disease-progression-and-management
#10
Mohan Natesan, Enoka Corea, Shivankari Krishnananthasivam, Harindra Darshana Sathkumara, Jennifer L Dankmeyer, Beverly K Dyas, Kei Amemiya, Aruna Dharshan De Silva, Robert G Ulrich
Melioidosis is a neglected tropical disease that is caused by the bacterium Burkholderia pseudomallei, and is underreported in many endemic countries. A long and costly administration of antibiotics is required to clear infections, and there is an unmet need for biomarkers to guide antibiotic treatment and increase the number of patients that complete therapy. We identified calprotectin as a lead biomarker of Burkholderia pseudomallei infections, and examined correlations between this serum protein and antibiotic treatment outcomes of melioidosis patients...
February 8, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28173858/mortality-trends-for-neglected-tropical-diseases-in-the-state-of-sergipe-brazil-1980-2013
#11
Marcos Antônio Costa de Albuquerque, Danielle Menezes Dias, Lucas Teixeira Vieira, Carlos Anselmo Lima, Angela Maria da Silva
BACKGROUND: Neglected Tropical Diseases are a set of communicable diseases that affect the population so low socioeconomic status, particularly 1.4 billion people who are living below the poverty level. This study has investigated the magnitude and mortality time trends for these diseases in the state of Sergipe, Northeast Region of Brazil. METHODS: We conducted an ecological study of time series, based on secondary data derived from the Mortality Information System of the Ministry of Health...
February 8, 2017: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/28166845/let-s-get-fissical-fast-in-silico-synchronization-as-a-new-tool-for-cell-division-cycle-analysis
#12
Brooke Morriswood, Markus Engstler
Cell cycle progression is a question of fundamental biological interest. The coordinated duplication and segregation of all cellular structures and organelles is however an extremely complex process, and one which remains only partially understood even in the most intensively researched model organisms. Trypanosomes are in an unusual position in this respect - they are both outstanding model systems for fundamental questions in eukaryotic cell biology, and pathogens that are the causative agents of three of the neglected tropical diseases...
February 7, 2017: Parasitology
https://www.readbyqxmd.com/read/28166826/socio-ecological-dynamics-and-challenges-to-the-governance-of-neglected-tropical-disease-control
#13
REVIEW
Edwin Michael, Shirin Madon
The current global attempts to control the so-called "Neglected Tropical Diseases (NTDs)" have the potential to significantly reduce the morbidity suffered by some of the world's poorest communities. However, the governance of these control programmes is driven by a managerial rationality that assumes predictability of proposed interventions, and which thus primarily seeks to improve the cost-effectiveness of implementation by measuring performance in terms of pre-determined outputs. Here, we argue that this approach has reinforced the narrow normal-science model for controlling parasitic diseases, and in doing so fails to address the complex dynamics, uncertainty and socio-ecological context-specificity that invariably underlie parasite transmission...
February 6, 2017: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/28158193/recombinant-snakebite-antivenoms-a-cost-competitive-solution-to-a-neglected-tropical-disease
#14
Andreas H Laustsen, Kristoffer H Johansen, Mikael Engmark, Mikael R Andersen
Snakebite envenoming is a major public health burden in tropical parts of the developing world. In sub-Saharan Africa, neglect has led to a scarcity of antivenoms threatening the lives and limbs of snakebite victims. Technological advances within antivenom are warranted, but should be evaluated not only on their possible therapeutic impact, but also on their cost-competitiveness. Recombinant antivenoms based on oligoclonal mixtures of human IgG antibodies produced by CHO cell cultivation may be the key to obtaining better snakebite envenoming therapies...
February 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28158185/schistosome-infectivity-in-the-snail-biomphalaria-glabrata-is-partially-dependent-on-the-expression-of-grctm6-a-guadeloupe-resistance-complex-protein
#15
Euan R O Allan, Jacob A Tennessen, Stephanie R Bollmann, Patrick C Hanington, Christopher J Bayne, Michael S Blouin
Schistosomiasis is one of the most important neglected tropical diseases. Despite effective chemotherapeutic treatments, this disease continues to afflict hundreds of millions of people. Understanding the natural intermediate snail hosts of schistosome parasites is vital to the suppression of this disease. A recently identified genomic region in Caribbean Biomphalaria glabrata snails strongly influences their resistance to infection by Schistosoma mansoni. This region contains novel genes having structural similarity to known pathogen recognition proteins...
February 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28152426/design-and-synthesis-of-a-new-series-of-3-5-disubstituted-isoxazoles-active-against-trypanosoma-cruzi-and-leishmania-amazonensis
#16
Rafael da Rosa, Milene Höehr de Moraes, Lara Almida Zimmermann, Eloir Paulo Schenkel, Mario Steindel, Lílian Sibelle Campos Bernardes
Chagas disease and leishmaniasis are neglected tropical diseases (NTDs) endemic in developing countries. Although there are drugs available for their treatment, efforts on finding new efficacious therapies are continuous. The natural lignans grandisin (1) and veraguensin (2) show activity against trypomastigote T. cruzi and their scaffold has been used as inspiration to design new derivatives with improved potency and chemical properties. We describe here the planning and microwave-irradiated synthesis of 26 isoxazole derivatives based on the structure of the lignans 1 and 2...
January 23, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28146095/synthesis%C3%A2-of%C3%A2-16%C3%A2-new%C3%A2-hybrids%C3%A2-from%C3%A2-tetrahydropyrans-derivatives%C3%A2-and%C3%A2-morita-baylis-hillman%C3%A2-adducts-%C3%A2-in-vitro%C3%A2-screening%C3%A2-against%C3%A2-leishmania%C3%A2-donovani
#17
Suervy Canuto de Oliveira Sousa, Juliana da Câmara Rocha, Tatjana de Souza Lima Keesen, Everton da Paz Silva, Priscilla Anne Castro de Assis, João Paulo Gomes de Oliveira, Saulo Luís Capim, Francisco José Seixas Xavier, Bruno Guimarães Marinho, Fábio Pedrosa Lins Silva, Claudio Gabriel Lima-Junior, Mário Luiz Araújo de Almeida Vasconcellos
Leishmaniases are a group of neglected tropical diseases (NTDs) caused by protozoan parasites from >20 Leishmania species. Visceral leishmaniasis (VL), also known as kala-aza, is the most severe form of leishmaniasis, usually fatal in the absence of treatment in 95% of cases. The Morita-Baylis-Hillman adducts (MBHAs) are being explored as drug candidates against several diseases, one of them being leishmaniasis. We present here the design, synthesis and in vitro screening against Leishmania donovani of sixteen new molecular hybrids from analgesic/antiinflammatory tetrahydropyrans derivatives and Morita-Baylis-Hillman adducts...
January 30, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28141850/correction-trypanosoma-brucei-cyp51-essentiality-and-targeting-therapy-in-an-experimental-model
#18
(no author information available yet)
[This corrects the article DOI: 10.1371/journal.pntd.0005125.].
January 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28138052/estimating-burdens-of-neglected-tropical-zoonotic-diseases-on-islands-with-introduced-mammals
#19
Luz A de Wit, Donald A Croll, Bernie Tershy, Kelly M Newton, Dena Spatz, Nick D Holmes, A Marm Kilpatrick
Many neglected tropical zoonotic diseases are maintained by introduced mammals, and on islands the most common introduced species are rodents, cats, and dogs. Management of introduced mammals, including control or eradication of feral populations, which is frequently done for ecological restoration, could also reduce or eliminate the diseases these animals carry. Understanding the burden of these zoonotic diseases is crucial for quantifying the potential public health benefits of introduced mammal management...
January 30, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28137745/multiple-introductions-and-recent-spread-of-the-emerging-human-pathogen-mycobacterium-ulcerans-across-africa
#20
Koen Vandelannoote, Conor J Meehan, Miriam Eddyani, Dissou Affolabi, Delphin Mavinga Phanzu, Sara Eyangoh, Kurt Jordaens, Françoise Portaels, Kirstie Mangas, Torsten Seemann, Laurent Marsollier, Estelle Marion, Annick Chauty, Jordi Landier, Arnaud Fontanet, Herwig Leirs, Timothy P Stinear, Bouke C de Jong
Buruli ulcer (BU) is an insidious neglected tropical disease. Cases are reported around the world but the rural regions of West and Central Africa are most affected. How BU is transmitted and spreads has remained a mystery, even though the causative agent, Mycobacterium ulcerans, has been known for more than 70 years. Here, using the tools of population genomics, we reconstruct the evolutionary history of M. ulcerans by comparing 165 isolates spanning 48 years and representing 11 endemic countries across Africa...
January 30, 2017: Genome Biology and Evolution
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