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https://www.readbyqxmd.com/read/28723951/cd8-t-cells-provide-immune-protection-against-murine-disseminated-endotheliotropic-orientia-tsutsugamushi-infection
#1
Guang Xu, Nicole L Mendell, Yuejin Liang, Thomas R Shelite, Yenny Goez-Rivillas, Lynn Soong, Donald H Bouyer, David H Walker
Scrub typhus, caused by a Gram-negative obligately intracellular coccobacillus, Orientia tsutsugamushi, is a long neglected but important tropical disease. Orientia tsutsugamushi causes illness in one million people each year, and 1 billion people are at risk. Without appropriate diagnosis and treatment, the disease can cause severe multiorgan failure with a case fatality rate of 7-15%. The current gaps in knowledge of immunity include the unknown mechanisms of host immunity to O. tsutsugamushi. Using an intravenous (i...
July 19, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28723904/impact-of-mass-drug-administration-for-elimination-of-lymphatic-filariasis-in-nepal
#2
Chet Raj Ojha, Basant Joshi, Khagendra Prakash Kc, Shyam Prakash Dumre, Keshav Kumar Yogi, Bandana Bhatta, Tulasi Adhikari, Kathryn Crowley, Babu Ram Marasaini
BACKGROUND: Lymphatic filariasis (LF) is a neglected tropical disease transmitted by mosquitoes. Nepal has implemented a national effort to eliminate LF by 2020 through mass drug administration (MDA) using diethylcarbamazine (DEC) and albendazole (ALB). We assessed the impact of MDAs on LF in selected districts of Nepal after the recommended six MDA rounds had been completed. METHODOLOGY AND PRINCIPAL FINDINGS: Baseline surveys were conducted in seven districts and mapping data were used as baseline in the other three districts before starting MDA in 2009...
July 19, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28721965/the-rise-of-global-health-diplomacy-an-interdisciplinary-concept-linking-health-and-international-relations
#3
Vijay Kumar Chattu
Global health diplomacy (GHD) is relatively a very new field that has yet to be clearly defined and developed though there are various definitions given by different experts from foreign policy, global health, diplomacy, international relations, governance, and law. With the intensification of globalization and increasing gaps between countries, new and reemerging health threats such as HIV/AIDS, tuberculosis, influenza, severe acute respiratory syndrome, Ebola, and Zika and a gradual rethinking on security concepts framed a new political context...
April 2017: Indian Journal of Public Health
https://www.readbyqxmd.com/read/28719274/risk-factors-for-podoconiosis-kamwenge-district-western-uganda-september-2015
#4
Christine Kihembo, Ben Masiira, William Z Lali, Gabriel K Matwale, Joseph K B Matovu, Frank Kaharuza, Alex R Ario, Immaculate Nabukenya, Issa Makumbi, Monica Musenero, Bao-Ping Zhu, Miriam Nanyunja
AbstractPodoconiosis, a noninfectious elephantiasis, is a disabling neglected tropical disease. In August 2015, an elephantiasis case-cluster was reported in Kamwenge District, western Uganda. We investigated to identify the disease's nature and risk factors. We defined a suspected podoconiosis case as onset in a Kamwenge resident of bilateral asymmetrical lower limb swelling lasting ≥ 1 month, plus ≥ 1 of the following associated symptoms: skin itching, burning sensation, plantar edema, lymph ooze, prominent skin markings, rigid toes, or mossy papillomata...
June 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28715423/antibody-trapping-a-novel-mechanism-of-parasite-immune-evasion-by-the-trematode-echinostoma-caproni
#5
Alba Cortés, Javier Sotillo, Carla Muñoz-Antolí, Javier Molina-Durán, J Guillermo Esteban, Rafael Toledo
BACKGROUND: Helminth infections are among the most prevalent neglected tropical diseases, causing an enormous impact in global health and the socioeconomic growth of developing countries. In this context, the study of helminth biology, with emphasis on host-parasite interactions, appears as a promising approach for developing new tools to prevent and control these infections. METHODS/PRINCIPAL FINDINGS: The role that antibody responses have on helminth infections is still not well understood...
July 17, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28700391/human-t-lymphotropic-virus-type-1-infection-and-disease-in-spain
#6
Carmen de Mendoza, Estrella Caballero, Antonio Aguilera, Silvia Requena, Raúl Ortiz de Lejarazu, María Pirón, Rocío González, Ana Jiménez, Lourdes Roc, Ana Treviño, Rafael Benito, Miriam Fernández-Alonso, Aitziber Aguinaga, Carmen Rodríguez, Juan García-Costa, Lidia Blanco, José M Ramos, Enrique Calderón, José M Eirós, Silvia Sauleda, Pablo Barreiro, Vicente Soriano
: Human T-lymphotropic virus type 1 (HTLV-1) infection is a neglected disease despite roughly 15 million people are chronically infected worldwide. Lifelong less than 10% of carriers develop life-threatening diseases, mostly a subacute myelopathy known as tropical spastic paraparesis (TSP) and a lymphoproliferative disorder named adult T-cell leukemia (ATL). HTLV-1 is efficiently transmitted perinatally (breastfeeding), sexually (more from men to women) and parenterally (transfusions, injection drug user (IDU), and transplants)...
July 31, 2017: AIDS
https://www.readbyqxmd.com/read/28700363/prospects-for-elimination-of-soil-transmitted-helminths
#7
Kristjana H Ásbjörnsdóttir, Arianna R Means, Marleen Werkman, Judd L Walson
PURPOSE OF REVIEW: Soil-transmitted helminths (STH) are endemic in 120 countries and are associated with substantial morbidity and loss of economic productivity. Although current WHO guidelines focus on morbidity control through mass drug administration (MDA), there is global interest in whether a strategy targeting disease elimination might be feasible in some settings. This review summarizes the prospects for switching from control to an elimination strategy. RECENT FINDINGS: STH control efforts have reduced the intensity of infections in targeted populations with associated reductions in morbidity...
July 11, 2017: Current Opinion in Infectious Diseases
https://www.readbyqxmd.com/read/28689507/a-survey-of-zoonotic-pathogens-carried-by-house-mouse-and-black-rat-populations-in-yucatan-mexico
#8
J A Panti-May, R R C DE Andrade, Y Gurubel-González, E Palomo-Arjona, L Sodá-Tamayo, J Meza-Sulú, M Ramírez-Sierra, E Dumonteil, V M Vidal-Martínez, C Machaín-Williams, D DE Oliveira, M G Reis, M A Torres-Castro, M R Robles, S F Hernández-Betancourt, F Costa
The house mouse (Mus musculus) and the black rat (Rattus rattus) are reservoir hosts for zoonotic pathogens, several of which cause neglected tropical diseases (NTDs). Studies of the prevalence of these NTD-causing zoonotic pathogens, in house mice and black rats from tropical residential areas are scarce. Three hundred and two house mice and 161 black rats were trapped in 2013 from two urban neighbourhoods and a rural village in Yucatan, Mexico, and subsequently tested for Trypanosoma cruzi, Hymenolepis diminuta and Leptospira interrogans...
July 10, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/28683127/mobile-phone-and-handheld-microscopy-for-neglected-tropical-diseases
#9
Jason Rajchgot, Jean T Coulibaly, Jennifer Keiser, Jürg Utzinger, Nathan C Lo, Michael K Mondry, Jason R Andrews, Isaac I Bogoch
No abstract text is available yet for this article.
July 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28677550/snake-bite-envenoming-a-priority-neglected-tropical-disease
#10
EDITORIAL
The Lancet
No abstract text is available yet for this article.
July 1, 2017: Lancet
https://www.readbyqxmd.com/read/28674055/screening-the-mmv-pathogen-box-across-multiple-pathogens-reclassifies-starting-points-for-open-source-drug-discovery
#11
Sandra Duffy, Melissa L Sykes, Amy J Jones, Todd B Shelper, Moana Simpson, Rebecca Lang, Sally-Ann Poulsen, Brad E Sleebs, Vicky M Avery
Open access drug discovery provides a substantial resource for diseases primarily affecting the poor and disadvantaged. The open access Pathogen Box is comprised of a collection of compounds with demonstrated biological activity against specific pathogenic organisms. The supply of this resource by the Medicines for Malaria Venture has the potential to provide new chemical starting points for a number of tropical and neglected diseases, through repurposing of these compounds for use in drug discovery campaigns for these additional pathogens...
July 3, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28673023/anemia-and-growth-retardation-associated-with-schistosoma-haematobium-infection-in-mali-a-possible-subtle-impact-of-a-neglected-tropical-disease
#12
Chalotte W Stecher, Moussa Sacko, Henry Madsen, Shona Wilson, Christian Wejse, Adama D Keita, Aly Landouré, Mamadou S Traoré, Per Kallestrup, Eskild Petersen, Birgitte Vennervald
Background: The aim of this cross-sectional study was to investigate a possible association of Schistosoma haematobium with child growth development and describe a plausible schistosomiasis-related anemia in children and adults in a highly schistosomiasis endemic area of Mali. Methods: Urine, feces and blood samples from 399 participants of both sexes (2-40 years of age) were analyzed and supplemented by anthropometric measurements. Results: S...
April 1, 2017: Transactions of the Royal Society of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28668673/the-chemotherapeutic-potential-of-chalcones-against-leishmaniases-a-review
#13
REVIEW
Nasir Tajuddeen, Murtala Bindawa Isah, Mukhtar Adeiza Suleiman, Fanie R van Heerden, Mohammed Auwal Ibrahim
Leishmaniases are endemic diseases in tropical and sub-tropical regions of the world and considered to be among the six most important neglected tropical diseases by the World Health Organization (WHO). The current therapeutic arsenal against the disease suffers from series of chemotherapeutic setbacks. However, since the early 1990s, naturally occurring chalcones with promising antileishmanial effects have been reported and several other synthetic chalcones and chalcone-hybrid molecules were confirmed to possess potent activity against various Leishmania species...
June 28, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28668230/global-funding-trends-for-malaria-research-in-sub-saharan-africa-a-systematic-analysis
#14
Michael G Head, Sian Goss, Yann Gelister, Victor Alegana, Rebecca J Brown, Stuart C Clarke, Joseph R A Fitchett, Rifat Atun, J Anthony G Scott, Marie-Louise Newell, Sabu S Padmadas, Andrew J Tatem
BACKGROUND: Total domestic and international funding for malaria is inadequate to achieve WHO global targets in burden reduction by 2030. We describe the trends of investments in malaria-related research in sub-Saharan Africa and compare investment with national disease burden to identify areas of funding strength and potentially neglected populations. We also considered funding for malaria control. METHODS: Research funding data related to malaria for 1997-2013 were sourced from existing datasets, from 13 major public and philanthropic global health funders, and from funding databases...
June 28, 2017: Lancet Global Health
https://www.readbyqxmd.com/read/28662054/first-evidence-of-lymphatic-filariasis-transmission-interruption-in-cameroon-progress-towards-elimination
#15
Hugues C Nana-Djeunga, Magellan Tchouakui, Guy R Njitchouang, Jules B Tchatchueng-Mbougua, Philippe Nwane, André Domche, Jean Bopda, Stève Mbickmen-Tchana, Julie Akame, Ann Tarini, Emilienne Epée, Benjamin D Biholong, Yaobi Zhang, Jean J Tougoue, Achille Kabore, Flobert Njiokou, Joseph Kamgno
BACKGROUND: Lymphatic filariasis (LF) is among the 10 neglected tropical diseases targeted for control or elimination by 2020. For LF elimination, the World Health Organization (WHO) has proposed a comprehensive strategy including (i) interruption of LF transmission through large-scale annual treatment (or mass drug administration (MDA)) of all eligible individuals in endemic areas, and (ii) alleviation of LF-associated suffering through morbidity management and disability prevention...
June 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28656524/identification-of-potential-trypanothione-reductase-inhibitors-among-commercially-available-formula-see-text-carboline-derivatives-using-chemical-space-lead-like-and-drug-like-filters-pharmacophore-models-and-molecular-docking
#16
Jorge Rodríguez-Becerra, Lizethly Cáceres-Jensen, José Hernández-Ramos, Lorena Barrientos
American trypanosomiasis or Chagas disease caused by the protozoan Trypanosoma cruzi (T. cruzi) is an important endemic trypanosomiasis in Central and South America. This disease was considered to be a priority in the global plan to combat neglected tropical diseases, 2008-2015, which indicates that there is an urgent need to develop more effective drugs. The development of new chemotherapeutic agents against Chagas disease can be related to an important biochemical feature of T. cruzi: its redox defense system...
June 27, 2017: Molecular Diversity
https://www.readbyqxmd.com/read/28649245/camelid-single-domain-antibodies-as-an-alternative-to-overcome-challenges-related-to-the-prevention-detection-and-control-of-neglected-tropical-diseases
#17
REVIEW
Carla F C Fernandes, Soraya Dos S Pereira, Marcos B Luiz, Juliana P Zuliani, Gilvan P Furtado, Rodrigo G Stabeli
Due mainly to properties such as high affinity and antigen specificity, antibodies have become important tools for biomedical research, diagnosis, and treatment of several human diseases. When the objective is to administer them for therapy, strategies are used to reduce the heterologous protein immunogenicity and to improve pharmacokinetic and pharmacodynamic characteristics. Size minimization contributes to ameliorate these characteristics, while preserving the antigen-antibody interaction site. Since the discovery that camelids produce functional antibodies devoid of light chains, studies have proposed the use of single domains for biosensors, monitoring and treatment of tumors, therapies for inflammatory and neurodegenerative diseases, drug delivery, or passive immunotherapy...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28648861/preparing-clinicians-for-re-emerging-arbovirus-infectious-diseases-in-europe
#18
REVIEW
Louise Sigfrid, Chantal Reusken, Isabella Eckerle, Veronique Nussenblatt, Sam Lipworth, Janey Messina, Moritz Kraemer, Onder Ergonul, Anna Papa, Marion Koopmans, Peter Horby
BACKGROUND: Arthropod-borne virus (Arbovirus) infections are considered an emerging threat for Europe, with an increase in cases in recent decades. The increase in global travel and trade has contributed to the introduction of vectors and viruses into new geographical areas. Tropical arboviruses such as dengue and chikungunya have re-emerged causing local, sporadic outbreaks ignited by travel-imported cases. The recent Zika virus outbreak in the Americas highlighted a need to strengthen preparedness to (re-)emerging arbovirus infections globally...
June 22, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28637488/a-high-throughput-colorimetric-assay-for-detection-of-schistosoma-mansoni-viability-based-on-the-tetrazolium-salt-xtt
#19
Pedro Henrique Nascimento Aguiar, Núbia Monteiro Gonçalves Soares Fernandes, Carlos Leomar Zani, Marina Moraes Mourão
BACKGROUND: Schistosoma mansoni is a trematode parasite that causes schistosomiasis, one of the most prevalent neglected tropical diseases, leading to the loss of 2.6 million disability-adjusted life years. Praziquantel is the only drug available, and new drugs are required. The most common strategy in schistosomiasis drug discovery is the use of the schistosomula larval-stage for a pre-screen in drug sensitivity assays. However, assessing schistosomula viability by microscopy has always been a limitation to the throughput of such assays...
June 21, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28636445/developing-a-casper-survey-to-assess-the-prevalence-of-risk-factors-for-neglected-tropical-diseases-in-texas
#20
Seth Smitherman, Tracy Hammond, Daniel Goldberg, Jennifer Horney
While more than a billion people live at risk of neglected tropical diseases in areas of Asia, sub-Saharan Africa, and Latin America, the degree to which such diseases burden countries like the United States is currently unclear. Even though many neglected tropical diseases such as dengue, leishmaniasis, and Chagas disease are not endemic to the United States, the possibility of their emergence is noteworthy, especially in states like Texas, which has high levels of poverty, a large immigrant population, and a climate amenable to the vectors for these diseases and is geographically proximate to endemic areas...
May 2017: Health Security
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