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Neglected tropical diseases

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https://www.readbyqxmd.com/read/28521698/leishmanicidal-and-trypanocidal-activity-of-metal-complexes-with-1-2-4-triazolo-1-5-a-pyrimidines-insights-on-their-therapeutic-potential-against-leishmaniasis-and-chagas-disease
#1
Juan M Salas, Ana B Caballero, Ginés M Esteban-Parra, José M Méndez-Arriaga
Since their first synthesis back in the early 20th century, 1,2,4-triazolo[1,5-a]pyrimidines have aroused increasing interest in very diverse areas ranging from chemotherapy to agriculture or even photography. Their similarity to purines confers a potential bioactivity and this feature has been wisely exploited for therapeutic use, including antifungal, antipyretic, analgesic, antiinflammatory, antitumoral and antiparasitic properties. In this review, we focus on the compounds that these nitrogen heterocycles form with metal ions and their antiparasitic activity and therapeutic potential against two neglected diseases of tropical prevalence, leishmaniasis and Chagas disease...
May 16, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28508167/lessons-from-a-15-year-old-boy-with-advanced-schistosomiasis-japonica-in-china-a-case-report
#2
REVIEW
Langui Song, Xiaoying Wu, An Ning, Zhongdao Wu
Schistosomiasis is a chronic, parasitic disease caused by flukes (trematodes) of the genus Schistosoma, which presents the most important global burden of the 17 neglected tropical diseases listed by the World Health Organization. China has made great achievements in schistosomiasis control, and now China is planning to move forward, to eliminate schistosomiasis within 2020, but the fact cannot be denied that the possibility of schistosome infection is still there in some endemic due to its zoonotic nature as well as wide distribution of its intermediate hosts (snails)...
May 16, 2017: Parasitology Research
https://www.readbyqxmd.com/read/28507113/efficacy-of-a-binuclear-cyclopalladated-compound-therapy-for-cutaneous-leishmaniasis-in-the-murine-model-of-infection-with-leishmania-amazonensis-and-its-inhibitory-effect-on-topoisomerase-1b
#3
Angela Maria Arenas Velásquez, Willian Campos Ribeiro, Vutey Venn, Silvia Castelli, Mariana Santoro, Renata Pires de Assis, Rodrigo Alves de Souza, Aline Rimoldi Ribeiro, Thaís Gaban Passalaqua, João Aristeu da Rosa, Amanda Martins Baviera, Antonio Eduardo Mauro, Alessandro Desideri, Elmo Eduardo Almeida-Amaral, Marcia A S Graminha
Leishmaniasis is a disease found throughout the (sub)tropical parts of the world caused by protozoan parasites of the Leishmania genus. Despite the numerous problems associated with existing treatments, pharmaceutical companies continue to neglect the development of better ones. The high toxicity of current drugs combined with emerging resistance makes the discovery of new therapeutic alternatives urgent. Here we report the evaluation of a binuclear cyclopalladated complex containing Pd(II) and N,N' -dimethylbenzylamine (Hdmba) against Leishmania amazonensis...
May 15, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28506839/evolutionary-relationships-among-protein-lysine-deacetylases-of-parasites-causing-neglected-diseases
#4
Larissa L S Scholte, Marina M Mourão, Fabiano Sviatopolk-Mirsky Pais, Jelena Melesina, Dina Robaa, Angela C Volpini, Wolfgang Sippl, Raymond J Pierce, Guilherme Oliveira, Laila A Nahum
The availability of the genomic data of diverse parasites provides an opportunity to identify new drug candidates against neglected tropical diseases affecting people worldwide. Histone modifying enzymes (HMEs) are potential candidates since they play key roles in the regulation of chromatin modifications, thus globally regulating gene expression. Furthermore, aberrant epigenetic states are often associated with human diseases, leading to great interest in HMEs as therapeutic targets. Our work focused on two families of protein lysine deacetylases (HDACs and sirtuins)...
May 13, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/28495384/medicinal-chemistry-of-antischistosomal-drugs-praziquantel-and-oxamniquine
#5
REVIEW
Vinícius Barros Ribeiro da Silva, Bruna Rafaella Koresch Leiva Campos, Jamerson Ferreira de Oliveira, Jean-Luc Decout, Maria do Carmo Alves de Lima
Neglected tropical diseases (NTDs) are a group of diseases that, besides prevailing in poverty conditions, contribute to the maintenance of social inequality, being a strong barrier to a country development. Schistosomiasis, a NTD, is a tropical and subtropical disease caused by the trematode Schistosoma mansoni (Africa, Middle East, Caribbean, Brazil, Venezuela, Suriname), japonicum (China, Indonesia, the Philippines), mekongi (several districts of Cambodia and the Lao People's Democratic Republic), intercalatum and guianensis (areas of tropical rainforests in Central Africa) and hematobium (Middle East Africa, Corsica, France) whose adult forms inhabit the mesenteric vessels of the host, while the intermediate forms are found in the aquatic gastropod snails of the genus Biomphalaria...
April 27, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28481900/yaws-resurgence-in-bankim-cameroon-the-relative-effectiveness-of-different-means-of-detection-in-rural-communities
#6
Alphonse Um Boock, Paschal Kum Awah, Ferdinand Mou, Mark Nichter
BACKGROUND: Yaws is an infectious, debilitating and disfiguring disease of poverty that mainly affects children in rural communities in tropical areas. In Cameroon, mass-treatment campaigns carried out in the 1950s reduced yaws to such low levels that it was presumed the disease was eradicated. In 2010, an epidemiological study in Bankim Health District detected 29 cases of yaws. Five different means of detecting yaws in clinical and community settings were initiated in Bankim over the following five years...
May 8, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28481502/efficient-inhibition-of-smnace-by-coordination-complexes-is-abolished-by-s-mansoni-sequestration-of-metal
#7
Hélène Muller-Steffner, Sylvain A Jacques, Isabelle Kuhn, Michael D Schultz, Davide Botta, Paul Osswald, Clarisse Maechling, Frances E Lund, Esther Kellenberger
SmNACE is a NAD catabolizing enzyme expressed on the outer tegument of S. mansoni, a human parasite that is one of the major agents of the neglected tropical disease Schistosomiasis. Recently, we identified aroylhydrazone derivatives capable of inhibiting the recombinant form of the enzyme with variable potency (IC50 ranging from 88 μM to 33 nM). In the present study, we investigated the mechanism of action of the least potent micromolar inhibitor (compound 1) and the most potent nanomolar inhibitor (compound 2) in the series on both the recombinant and native SmNACE enzymes...
May 8, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/28472981/infectious-diseases-of-poverty-the-first-five-years
#8
EDITORIAL
Wei Wang, Jin Chen, Hui-Feng Sheng, Na-Na Wang, Pin Yang, Xiao-Nong Zhou, Robert Bergquist
Although the focus in the area of health research may be shifting from infectious to non-communicable diseases, the infectious diseases of poverty remain a major burden of disease of global health concern. A global platform to communicate and share the research on these diseases is needed to facilitate the translation of knowledge into effective approaches and tools for their elimination. Based on the "One health, One world" mission, a new, open-access journal, Infectious Diseases of Poverty (IDP), was launched by BioMed Central in partnership with the National Institute of Parasitic Diseases (NIPD), Chinese Center for Disease Control and Prevention (China CDC) on October 25, 2012...
May 4, 2017: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/28472570/scabies-a-clinical-update
#9
Myra Hardy, Daniel Engelman, Andrew Steer
BACKGROUND: Scabies is a common, yet neglected, skin disease. Scabies occurs across Australia, but most frequently in socioeconomically disadvantaged populations in tropical regions, including in remote Aboriginal and Torres Strait Islander communities. In temperate settings, the disease clusters in institutional care facilities. OBJECTIVE: The objective of this article is to provide updates on the clinical diagnosis and treatment approaches for scabies in Australia...
2017: Australian Family Physician
https://www.readbyqxmd.com/read/28464027/correction-mosqtent-an-individual-portable-protective-double-chamber-mosquito-trap-for-anthropophilic-mosquitoes
#10
(no author information available yet)
[This corrects the article DOI: 10.1371/journal.pntd.0005245.].
May 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28463964/correction-management-and-modeling-approaches-for-controlling-raccoon-rabies-the-road-to-elimination
#11
(no author information available yet)
[This corrects the article DOI: 10.1371/journal.pntd.0005249.].
May 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28463883/htlv-1-infection-and-disease-in-spain
#12
Carmen de Mendoza, Estrella Caballero, Antonio Aguilera, Silvia Requena, Raúl Ortiz de Lejarazu, María Pirón, Rocío González, Ana Jiménez, Lourdes Roc, Ana Treviño, Rafael Benito, Miriam Fernández-Alonso, Aitziber Aguinaga, Carmen Rodríguez, Juan García-Costa, Lidia Blanco, José M Ramos, Enrique Calderón, José M Eirós, Silvia Sauleda, Pablo Barreiro, Vicente Soriano
: Human T-lymphotropic virus type 1 (HTLV-1) infection is a neglected disease despite roughly 15 million people are chronically infected worldwide. Lifelong less than 10% of carriers develop life-threatening diseases, mostly a subacute myelopathy known as tropical spastic paraparesis (TSP) and a lymphoproliferative disorder named adult T-cell leukemia (ATL). HTLV-1 is efficiently transmitted perinatally (breastfeeding), sexually (more from male to female) and parenterally (transfusions, injection drug use and transplants)...
May 1, 2017: AIDS
https://www.readbyqxmd.com/read/28463130/offline-the-new-neglected-non-tropical-diseases
#13
Richard Horton
No abstract text is available yet for this article.
April 29, 2017: Lancet
https://www.readbyqxmd.com/read/28462832/6-nitro-2-3-dihydroimidazo-2-1-b-1-3-thiazoles-facile-synthesis-and-comparative-appraisal-against-tuberculosis-and-neglected-tropical-diseases
#14
Andrew M Thompson, Adrian Blaser, Brian D Palmer, Robert F Anderson, Sujata S Shinde, Delphine Launay, Eric Chatelain, Louis Maes, Scott G Franzblau, Baojie Wan, Yuehong Wang, Zhenkun Ma, William A Denny
As part of a quest for backups to the antitubercular drug pretomanid (PA-824), we investigated the unexplored 6-nitro-2,3-dihydroimidazo[2,1-b][1,3]-thiazoles and related -oxazoles. The nitroimidazothiazoles were prepared in high yield from 2-bromo-4-nitroimidazole via heating with substituted thiiranes and diisopropylethylamine. Equivalent examples of these two structural classes provided broadly comparable MICs, with 2-methyl substitution and extended aryloxymethyl side chains preferred; albeit, S-oxidised thiazoles were ineffective for tuberculosis...
March 27, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28461312/knockdown-of-host-antioxidant-defense-genes-enhances-the-effect-of-glucantime-on-intracellular-leishmania-braziliensis-in-human-macrophages
#15
Jair Téllez, Ibeth Romero, Maurilio José Soares, Mario Steindel, Alvaro José Romanha
Leishmaniasis is a neglected tropical disease affecting millions of people worldwide and represents a major public health problem. Information on protein expression patterns and functional roles within the context of Leishmania-infected human monocyte-derived macrophages (MDMs) under drug treatment conditions are essential to understand the role of these cells in leishmaniasis treatment. We analyzed functional changes in expression of human MDM genes and proteins during in vitro infection by Leishmania braziliensis and treatment with Glucantime (Sb(V)) using quantitative polymerase chain reaction (qPCR) arrays, western blotting, confocal microscopy and short-interfering RNA (siRNA) human gene-inhibition assays...
May 1, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28460833/application-of-nanotechnology-in-treatment-of-leishmaniasis-a-review
#16
REVIEW
Maryam Akbari, Ahmad Oryan, Gholamreza Hatam
Leishmaniasis is a neglected tropical disease caused by a protozoan species of the genus Leishmania affecting mostly the developing countries. The disease with current mortality rate of 50,000 deaths per year threatens approximately 350 million people in more than 90 countries all over the world. Cutaneous, mucocutaneous and visceral leishmaniasis are the most frequent forms of the disease. Chemotherapy still relies on the use of pentavalent antimonials, amphotericin B, liposomal amphotericin B and miltefosin...
April 28, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28455127/oxidative-stress-in-mayaro-virus-infection
#17
Fernanda Caetano Camini, Camila Carla da Silva Caetano, Letícia Trindade Almeida, Joyce Ferreira da Costa Guerra, Breno de Mello Silva, Silvana de Queiroz Silva, José Carlos de Magalhães, Cintia Lopes de Brito Magalhães
Mayaro virus (MAYV) is a neglected tropical arbovirus that causes a febrile syndrome that is sometimes accompanied by incapacitating arthritis/arthralgia. The pathogenesis of MAYV has not been completely defined and oxidative stress mediated by an increase in reactive oxygen species (ROS) and/or depletion of antioxidant defences has been found to contribute to several aspects of viral disease. To investigate whether MAYV induced oxidative stress in host cells, we monitored ROS production, oxidative stress markers and antioxidant defences at different time points after infection...
April 25, 2017: Virus Research
https://www.readbyqxmd.com/read/28450853/micromanagement-of-immune-system-role-of-mirnas-in-helminthic-infections
#18
REVIEW
Naina Arora, Shweta Tripathi, Aloukick K Singh, Prosenjit Mondal, Amit Mishra, Amit Prasad
Helminthic infections fall under neglected tropical diseases, although they inflict severe morbidity to human and causes major economic burden on health care system in many developing countries. There is increased effort to understand their immunopathology in recent days due to their immuno-modulatory capabilities. Immune response is primarily controlled at the transcriptional level, however, microRNA-mediated RNA interference is emerging as important regulatory machinery that works at the translation level...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28450515/draft-genome-sequence-of-mycobacterium-ulcerans-s4018-isolated-from-a-patient-with-an-active-buruli-ulcer-in-benin-africa
#19
Stanimir Kambarev, Stéphane Corvec, Annick Chauty, Estelle Marion, Laurent Marsollier, Frédéric Pecorari
Currently, there are only two publicly available genomes of Mycobacterium ulcerans-the causative agent of the neglected, but devastating, tropical disease Buruli ulcer. Here, we report the draft genome sequence of isolate S4018, recovered from an active cutaneous lesion of a patient with Buruli ulcer in Benin, Africa.
April 27, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28448950/promoting-innovation-in-small-markets-evidence-from-the-market-for-rare-and-intractable-diseases
#20
Toshiaki Iizuka, Gyo Uchida
In many medical care markets with limited profit potential, firms often have little incentive to innovate. These include the market for rare diseases, "neglected" tropical diseases, and personalized medicine. Governments and not-for-profit organizations promote innovation in such markets but empirical evidence on the policy effect is limited. We study this issue by analyzing the impact of a demand-side policy in Japan, which reduces the cost sharing of patients with some rare and intractable diseases and attempts to establish and promote the treatment of those diseases...
April 1, 2017: Journal of Health Economics
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