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nephrotic syndrome elderly

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https://www.readbyqxmd.com/read/27855638/alteration-of-histone-h3k4-methylation-in-glomerular-podocytes-associated-with-proteinuria-in-patients-with-membranous-nephropathy
#1
Takayuki Fujino, Naoyuki Hasebe
BACKGROUND: Histone H3K4 trimethylation (H3K4 me3) is found in active euchromatic regions and plays an important role in podocyte function in which actin filaments are abundant in the foot processes. The pathogenesis of membranous nephropathy (MN), the most prevalent cause of primary nephrotic syndrome in the middle-aged and elderly, is podocyte dysfunction. METHODS: We investigated the role of H3K4 me3 in podocyte dysfunction in nephrotic syndrome using cultured podocytes and a mouse proteinuria model induced by LPS...
November 17, 2016: BMC Nephrology
https://www.readbyqxmd.com/read/27596627/biopsy-proven-kidney-diseases-in-the-elderly-clinical-characteristics-renal-histopathological-spectrum-and-prognostic-factors
#2
Yue Chen, Ping Li, Chunli Cui, Aihong Yuan, Kun Zhang, Chen Yu
OBJECTIVE: To explore the clinical characteristics, renal histopathological spectrum and prognostic factors of biopsy-proven kidney diseases in the elderly. METHODS: A retrospective observational study was conducted in elderly patients who had received renal biopsies. Demographic, clinical and pathological data at the time of the biopsy were collected from the medical records. Follow-up records and prognostic factors were studied. RESULTS: The elderly (≥60 years) accounted for 74 of 434 (17...
September 5, 2016: Journal of International Medical Research
https://www.readbyqxmd.com/read/27536673/management-of-membranous-nephropathy-in-western-countries
#3
REVIEW
Talal Alfaadhel, Daniel Cattran
BACKGROUND: Idiopathic membranous nephropathy (IMN) is a common cause of nephrotic syndrome (NS) in adults in Western countries. In 2012, the KDIGO (Kidney Disease: Improving Global Outcomes) working group published guidelines for the management of glomerulonephritis, thus providing a template for the treatment of this condition. While being aware of the impact of the clinicians' acumen and that patients may choose a different therapeutic option due to the risks of specific drugs and also of the evolving guidelines, this review details our approach to the management of patients with IMN in a Western center (Toronto)...
September 2015: Kidney Diseases
https://www.readbyqxmd.com/read/27536672/management-of-membranous-nephropathy-in-asia
#4
REVIEW
Jing Xu, Xiaofan Hu, Jingyuan Xie, Nan Chen
BACKGROUND: Membranous nephropathy (MN) is the most common cause of nephrotic syndrome (NS) in adults, accounting for about 20.0% of all NS cases. With an increasing prevalence, especially in the elderly, it has received great attention in Asia. SUMMARY: Recently, the prevalence of idiopathic MN (IMN) has significantly increased among the elderly people in Asia and other places in the world. Although the exact mechanism of IMN remains unveiled, the identification of new antigens such as PLA2R and THSD7A has greatly enhanced our understanding of its pathogenesis...
September 2015: Kidney Diseases
https://www.readbyqxmd.com/read/27297947/novel-type-of-renal-amyloidosis-derived-from-apolipoprotein-cii
#5
Samih H Nasr, Surendra Dasari, Linda Hasadsri, Jason D Theis, Julie A Vrana, Morie A Gertz, Prasuna Muppa, Michael T Zimmermann, Karen L Grogg, Angela Dispenzieri, Sanjeev Sethi, W Edward Highsmith, Giampaolo Merlini, Nelson Leung, Paul J Kurtin
Amyloidosis is characterized by extracellular deposition of misfolded proteins as insoluble fibrils. Most renal amyloidosis cases are Ig light chain, AA, or leukocyte chemotactic factor 2 amyloidosis, but rare hereditary forms can also involve the kidneys. Here, we describe the case of a 61-year-old woman who presented with nephrotic syndrome and renal impairment. Examination of the renal biopsy specimen revealed amyloidosis with predominant involvement of glomeruli and medullary interstitium. Proteomic analysis of Congo red-positive deposits detected large amounts of the Apo-CII protein...
June 13, 2016: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/27241076/-giant-cell-aortitis-complicated-by-aa-amyloidosis-diagnosed-with-imaging-techniques-report-of-a-case
#6
J-P Hammelin, G Cardon, M Reberolle, F Moulonguet, Y Neugebauer, G Raybaud, V Gnemmi, E Hachulla
INTRODUCTION: AA amyloidosis is a common but severe complication of many chronic inflammatory processes of infectious, autoimmune, or neoplastic origin. It frequently leads to renal damage, often presenting as a nephrotic syndrome. Giant cell arteritis is a common inflammatory arteritis in elderly people, but rarely complicated by AA amyloidosis. CASE REPORT: We report an 87-year-old female who presented with a nephrotic syndrome and a chronic inflammation, in whom the kidney biopsy showed secondary amyloidosis...
May 27, 2016: La Revue de Médecine Interne
https://www.readbyqxmd.com/read/26844777/renal-biopsy-in-2015-from-epidemiology-to-evidence-based-indications
#7
Marco Fiorentino, Davide Bolignano, Vladimir Tesar, Anna Pisano, Wim Van Biesen, Graziella D'Arrigo, Giovanni Tripepi, Loreto Gesualdo
BACKGROUND: Although the number of patients reaching end-stage kidney disease without a biopsy-proven diagnosis is increasing, the utility of renal biopsy is still an object of debate. We analyzed epidemiological data and the main indications for renal biopsy with a systematic, evidence-based review at current literature. SUMMARY: There is a high discrepancy observed in biopsy rates and in the epidemiology of glomerular diseases worldwide, related to the different time frame of the analyzed reports, lack of data collection, the different reference source population and the heterogeneity of indications...
2016: American Journal of Nephrology
https://www.readbyqxmd.com/read/26759328/pattern-of-biopsy-proven-kidney-disease-in-the-elderly-in-a-tertiary-care-hospital-in-india-a-clinicopathological-study
#8
Soumita Bagchi, Parmod Mittal, Geetika Singh, Sanjay Kumar Agarwal, Lavleen Singh, Dipankar Bhowmik, Sandeep Mahajan, Amit Dinda
BACKGROUND: An aging population is an important demographic issue in India. The knowledge base about kidney diseases among the elderly Indians is inadequate. We aim to delineate the clinical profile and spectrum of biopsy-proven kidney disease in elderly patients. METHODS: Records of all elderly patients (≥60 years) who had undergone kidney biopsy in the nephrology department from January 2010 to December 2014 were reviewed. Their clinical details and laboratory investigations at the time of biopsy were noted...
April 2016: International Urology and Nephrology
https://www.readbyqxmd.com/read/26590949/drug-induced-kidney-disease-a-study-of-the-japan-renal-biopsy-registry-from-2007-to-2015
#9
Hitoshi Yokoyama, Ichie Narita, Hitoshi Sugiyama, Michio Nagata, Hiroshi Sato, Yoshihiko Ueda, Seiichi Matsuo
INTRODUCTION: The Japan Renal Biopsy Registry (J-RBR) was started in 2007 by the Committee for the Standardization of Renal Pathological Diagnosis and the Committee for the Kidney Disease Registry of the Japanese Society of Nephrology. The purpose of this report is to clarify drug-induced kidney disease (DIKD) of renal biopsied cases in Japan. SUBJECTS AND METHODS: We analyzed the data of 26,535 cases that were registered in the J-RBR from 2007 to 2015. RESULTS: Based on clinical and pathological diagnoses, 328 cases (176 males and 152 females) of renal biopsy-proven DIKD were registered in the J-RBR from 2007 to 2015 (1...
October 2016: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/26568005/light-chain-deposition-disease-successfully-treated-with-bortezomib-in-an-elderly-patient-a-case-report-and-review-of-the-literature
#10
REVIEW
Yukihiro Wada, Masayuki Iyoda, Tomohiro Saito, Noriko Arai-Nunota, Ken Iseri, Eiko Tomita, Misa Ikeda, Yutaka Yamaguchi, Takanori Shibata
We herein report the case of an elderly patient with light-chain deposition disease (LCDD) successfully treated with bortezomib. An 83-year-old woman was admitted because of nephrotic syndrome. She was diagnosed to have monoclonal gammopathy of undetermined significance (IgG-κ type) and LCDD, on the basis of serum and urinary immunoelectrophoresis and renal biopsy. She responded to a modified regimen of bortezomib-based chemotherapy with disappearance of proteinuria without any adverse effects. According to a literature review of 16 cases, including the present case, bortezomib-based chemotherapy appears to be a convincing strategy for the treatment of LCDD even in elderly patients...
2015: Internal Medicine
https://www.readbyqxmd.com/read/26154635/clinical-and-epidemiological-prevalence-of-glomerulopathies-elderly-in-the-city-of-uberaba-mg
#11
Lethícia Borges Oliveira, Eliangela de Castro Cobo, Juliana Reis Machado, Fabiano Bichuette Custódio, Marcos Vinícius da Silva, Flávia Aparecida de Oliveira, Rosana Rosa Miranda Correa, Marlene Antônia dos Reis
INTRODUCTION: Currently, the elderly population of Brazil is suffering significant increase. Aging is a physiological process that causes changes in various organs, including the kidney. A kidney biopsy is of paramount importance to clarify the morphological changes of these entities. OBJECTIVES: The aim of this work was to conduct a clinical epidemiological analysis of elderly patients and evaluate the prevalence of major glomerulopathies that affect. METHODS: This is a retrospective and descriptive, with a review of 104 reports of renal biopsies of elderly aged over 60 years, performed in the Nefropatologia Federal University of Triângulo Mineiro (UFTM), between periods January 1996 and December 2010...
April 2015: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
https://www.readbyqxmd.com/read/26135198/renal-biopsy-in-the-elderly-a-single-center-experience
#12
Ozlem Harmankaya, Yildiz Okuturlar, Hakan Kocoglu, Hakan Kaptanogullari, Sibel Kocak Yucel, Hanise Ozkan, Didem Acarer, Ezgi Erdogan, Murvet Yilmaz, Mehmet Hursitoglu
OBJECTIVE: Aging population has been increasing worldwide. So the number of elderly patients presenting with kidney disease has also been increasing. In this retrospective study, we assessed biopsy results of elderly patients and their clinical presentations. MATERIALS AND METHODS: Native renal biopsy results of 98 elderly patients (≥65 years) were analyzed. These 98 patients consisted of 56 males (57.1 %) and 42 females (42.9 %) with a mean age of 70.59 ± 5...
August 2015: International Urology and Nephrology
https://www.readbyqxmd.com/read/25949940/primary-glomerular-diseases-in-the-elderly
#13
REVIEW
Abdullah Sumnu, Meltem Gursu, Savas Ozturk
Primary glomerular diseases in the elderly population are a frustrating topic due to difficulties in both the diagnosis and decision making about treatment. The most frequent type of primary glomerular disease in elderly is membranous nephropathy; while its counterpart in younger population is IgA nephropathy. The most frequent cause of nephrotic syndrome in the elderly is also membranous nephropathy. Pauci-immune crescentic glomerulonephritis (GN) rate increases both in elderly and very elderly population...
May 6, 2015: World Journal of Nephrology
https://www.readbyqxmd.com/read/25922591/successful-prednisolone-therapy-in-elderly-patients-with-severe-forms-of-henoch-sch%C3%A3-nlein-purpura-nephritis
#14
Saiko Kato-Okada, Hiromichi Suzuki, Tsutomu Inoue, Tomohiro Kikuta, Hirokazu Okada
INTRODUCTION: Recently, Henoch-Schönlein purpura (HSP) has been observed in elderly people, although it was believed to be uncommon in these subjects. The increased risks of developing end-stage renal disease (ESRD) in adults in comparison with children were highlighted by different studies; however, limited data are available on the treatment of HSP nephritis in adults. METHODS: Between 2002 and 2008, five elderly Japanese patients (>65 years old) (mean age, 68 years, ranging from 65 to 72) with severe forms of HSP nephritis were entered into a prospective study to evaluate prednisolone therapy on the outcome of nephropathy in terms of clinical symptoms and histopathological changes...
2015: Japanese Clinical Medicine
https://www.readbyqxmd.com/read/25719287/increased-hospital-admissions-associated-with-extreme-heat-exposure-in-king-county-washington-1990-2010
#15
Tania Busch Isaksen, Michael G Yost, Elizabeth K Hom, You Ren, Hilary Lyons, Richard A Fenske
Increased morbidity and mortality have been associated with extreme heat events, particularly in temperate climates. Few epidemiologic studies have considered the impact of extreme heat events on hospitalization rates in the Pacific Northwest region. This study quantifies the historic (May to September 1990-2010) heat-morbidity relationship in the most populous Pacific Northwest County, King County, Washington. A relative risk (RR) analysis was used to explore the association between heat and all non-traumatic hospitalizations on 99th percentile heat days, whereas a time series analysis using a piecewise linear model approximation was used to estimate the effect of heat intensity on hospitalizations, adjusted for temporal trends and day of the week...
2015: Reviews on Environmental Health
https://www.readbyqxmd.com/read/25657979/epidemiological-clinical-and-laboratorial-profile-of-renal-amyloidosis-a-12-year-retrospective-study-of-37-cases
#16
Elissa Oliveira da Fonseca, Porphirio Jose Soares Filho, Licinio Esmeraldo da Silva, Maria Lucia Ribeiro Caldas
BACKGROUND: Renal amyloidosis is one of the main differential diagnoses in the investigation of nephrotic proteinuria in adults, especially elderly patients. OBJECTIVES: The aim of this article is to contribute to international research with epidemiologic data of renal amyloidosis, given the lack of uniformity described in the literature. PATIENTS AND METHODS: A retrospective study of 37 cases of renal amyloidosis diagnosed by kidney biopsy, between 2000 and 2011, considering epidemiological, clinical and laboratory data...
January 2015: Journal of Nephropathology
https://www.readbyqxmd.com/read/25539617/a-clinicopathological-study-of-renal-biopsies-from-288-elderly-patients-analysis-based-on-4-185-cases
#17
Fan Yang, Bing Li, Wenpeng Cui, Chunyan He, Shujun Liu, Qiaoyan Guo, Man Wu, Lining Miao, Ping Luo
PURPOSE: To investigate the clinical characteristics and histopathological features of kidney disease in elderly patients. METHODS: We retrospectively analyzed the results of 4,185 consecutive renal biopsies, and 288 patients aged >60 years at the Second Hospital of Jilin University from January 1998 to December 2013 were finally included. All patients had been clinically and histologically diagnosed with kidney disease. RESULTS: Nephrotic syndrome was the main clinical indication for biopsy...
February 2015: International Urology and Nephrology
https://www.readbyqxmd.com/read/25526441/the-renal-histopathology-spectrum-of-elderly-patients-with-kidney-diseases-a-study-of-430-patients-in-a-single-chinese-center
#18
Ping Zhu, Fu-de Zhou, Ming-hui Zhao
The elderly population has significantly increased in China. However, data regarding renal histopathology in this population is lacking. The present study retrospectively analyzed renal disease spectrum of 430 elderly patients who had received renal biopsy at Peking University First Hospital between January 2003 and December 2012. Among 6049 patients receiving renal biopsies during the same period, 430 (7.10%) were elderly (≥65 years). The ratio of male (263 patients) to female (167 patients) was 1.57:1, with an age of 70...
December 2014: Medicine (Baltimore)
https://www.readbyqxmd.com/read/25298141/study-of-mizoribine-therapy-in-elderly-patients-with-membranous-nephropathy-comparison-with-patients-not-receiving-mizoribine
#19
COMPARATIVE STUDY
Takafumi Ito, Kaori Mochizuki, Tomohiro Oka, Ken Hanada, Kazuaki Tanabe
BACKGROUND: We have previously reported the results of mizoribine (MZR) treatment for elderly patients with membranous nephropathy (MN). Here, we retrospectively compared these patients with those who had been initially treated with prednisolone (PSL) alone. METHODS: The subjects were patients with MN aged ≥65 years who were examined between April 2007 and September 2010 and followed for at least 1 year. RESULTS: The median period until the start of treatment in the MZR group (MZR-G) was 60 days...
January 2015: International Urology and Nephrology
https://www.readbyqxmd.com/read/25230687/outcomes-of-primary-nephrotic-syndrome-in-elderly-japanese-retrospective-analysis-of-the-japan-renal-biopsy-registry-j-rbr
#20
Hitoshi Yokoyama, Hitoshi Sugiyama, Ichiei Narita, Takao Saito, Kunihiro Yamagata, Saori Nishio, Shouichi Fujimoto, Noriko Mori, Yukio Yuzawa, Seiya Okuda, Shoichi Maruyama, Hiroshi Sato, Yoshihiko Ueda, Hirofumi Makino, Seiichi Matsuo
BACKGROUND AND OBJECTIVES: There are very little data available regarding nephrotic syndrome (NS) in elderly (aged ≥65 years) Japanese. The aim of this study was to examine the causes and outcomes of NS in elderly patients who underwent renal biopsies between 2007 and 2010. DESIGN, SETTING, PARTICIPANTS, AND MEASUREMENTS: From July 2007 to June 2010, all of the elderly (aged ≥65 years) Japanese primary NS patients who underwent native renal biopsies and were registered in the Japan renal biopsy registry (J-RBR; 438 patients including 226 males and 212 females) were identified...
June 2015: Clinical and Experimental Nephrology
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