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https://www.readbyqxmd.com/read/28099459/correction-the-burden-of-leprosy-in-cameroon-fifteen-years-into-the-post-elimination-era
#1
Earnest Njih Tabah, Dickson Shey Nsagha, Anne-Cecile Zoung-Kanyi Bissek, Martin W Bratschi, Theophilus Ngeh Njamnshi, Gerd Pluschke, Alfred Kongnyu Njamnshi
[This corrects the article DOI: 10.1371/journal.pntd.0005012.].
January 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28094163/granulomatous-histiocytic-dermatitides
#2
Mark R Wick
Granulomas of the skin may be classified in several ways. They are either infectious or non-infectious in character, and they contain areas of necrobiosis or necrosis, or not. Responsible infectious agents may be mycobacterial, fungal, treponemal, or parasitic organisms, and each case of granulomatous dermatitis should be assessed histochemically for those microbes. In the non-infectious group, examples of necrobiotic or necrotizing granulomas include granuloma annulare; necrobiosis lipoidica; rheumatoid nodule; and lupus miliaris disseminates faciei...
December 14, 2016: Seminars in Diagnostic Pathology
https://www.readbyqxmd.com/read/28088473/endothelium-adhesion-molecules-icam-1-icam-2-vcam-1-and-vla-4-expression-in-leprosy
#3
Juarez de Sousa, Tinara Leila Sousa Aarão, Jorge Rodrigues de Sousa, Kelly Emi Hirai, Luciana Mota Silva, Leonidas Braga Dias, Francisca Regina Oliveira Carneiro, Hellen Thais Fuzii, Juarez Aantonio Simoes Quaresma
Leprosy triggers a complex relationship between the pathogen and host immune response. Endothelium plays an important role in this immune response by directly influencing cell migration to infected tissues. The objective of this work is to investigate the possible role of endothelium in M. leprae infection, correlating the characteristics of endothelial markers with the expression pattern of cytokines. Thirty-six skin biopsy samples were cut into 5-μm thick sections and stained with hematoxylin-eosin and Ziehl-Neelsen for morphological analysis and then submitted to immunohistochemical analysis using monoclonal antibodies against ICAM-1, ICAM-2, VCAM-1, and VLA-4...
January 11, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28081131/-i-wasted-3-years-thinking-it-s-not-a-problem-patient-and-health-system-delays-in-diagnosis-of-leprosy-in-india-a-mixed-methods-study
#4
Thirumugam Muthuvel, Srinivas Govindarajulu, Petros Isaakidis, Hemant Deepak Shewade, Vasudev Rokade, Rajbir Singh, Sanjeev Kamble
BACKGROUND: Worldwide, leprosy is one of the major causes of preventable disability. India contributes to 60% of global leprosy burden. With increasing numbers of leprosy with grade 2 disability (visible disability) at diagnosis, we aimed to determine risk factors associated with grade 2 disability among new cases and explore patients and providers' perspectives into reasons for late presentation. METHODOLOGY/PRINCIPAL FINDINGS: This was an explanatory mixed-methods study where the quantitative component, a matched case-control design, was followed by a qualitative component...
January 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28073313/conjugal-leprosy-is-there-a-need-for-active-surveillance-in-endemic-areas
#5
Anuradha Jindal, Smitha S Prabhu, Shrutakirthi D Shenoi, Kanthilatha Pai, Sudhir Nayak
No abstract text is available yet for this article.
January 1, 2017: Tropical Doctor
https://www.readbyqxmd.com/read/28071955/leprosy
#6
Colin Binns, Wah Yun Low
No abstract text is available yet for this article.
October 2016: Asia-Pacific Journal of Public Health
https://www.readbyqxmd.com/read/28056107/autophagy-is-an-innate-mechanism-associated-with-leprosy-polarization
#7
Bruno Jorge de Andrade Silva, Mayara Garcia de Mattos Barbosa, Priscila Ribeiro Andrade, Helen Ferreira, José Augusto da Costa Nery, Suzana Côrte-Real, Gilberto Marcelo Sperandio da Silva, Patricia Sammarco Rosa, Mario Fabri, Euzenir Nunes Sarno, Roberta Olmo Pinheiro
Leprosy is a chronic infectious disease that may present different clinical forms according to the immune response of the host. Levels of IFN-γ are significantly raised in paucibacillary tuberculoid (T-lep) when compared with multibacillary lepromatous (L-lep) patients. IFN-γ primes macrophages for inflammatory activation and induces the autophagy antimicrobial mechanism. The involvement of autophagy in the immune response against Mycobacterium leprae remains unexplored. Here, we demonstrated by different autophagic assays that LC3-positive autophagosomes were predominantly observed in T-lep when compared with L-lep lesions and skin-derived macrophages...
January 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28054225/spectrum-and-burden-of-neglected-tropical-diseases-observed-in-an-infectious-and-tropical-diseases-unit-in-florence-italy-2000-2015
#8
Lorenzo Zammarchi, Iacopo Vellere, Leonardo Stella, Filippo Bartalesi, Marianne Strohmeyer, Alessandro Bartoloni
Neglected tropical diseases (NTDs) are a diverse group of acute and chronic conditions with distinct characteristics that thrive mainly among the poorest populations, almost exclusively in tropical countries. To evaluate the relevance and impact of NTDs in a temperate area, the number and features of patients diagnosed with NTDs at the Infectious and Tropical Diseases Unit (ITDU), Azienda Ospedaliero-Universitaria Careggi, Florence, Italy between 2000 and 2015 were retrospectively reviewed. Overall 289 NTD cases were diagnosed in 283 subjects accounting for 2...
January 4, 2017: Internal and Emergency Medicine
https://www.readbyqxmd.com/read/28052367/morphoea-with-prominent-plasma-cell-endoneuritis
#9
M Singh, N Farquharson, C Owen, A J Howat, S Singh, N Francis, E Calonje
Morphoea (localized scleroderma) is a cutaneous inflammatory condition characterized by the development of indurated and discoloured plaques. The histological features of morphoea typically include a superficial and deep perivascular and periadnexal chronic inflammatory infiltrate associated with variable degrees of dermal and/or subcutaneous sclerosis. The infiltrate is typically composed of lymphocytes, macrophages and conspicuous plasma cells. The early stages of morphoea may have a very prominent inflammatory infiltrate associated with subtle sclerosis...
January 4, 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/28050374/infectious-granulomatous-dermatitis-at-a-tertiary-care-centre-in-north-maharashtra-a-histopathological-study
#10
Rajeshwari Kumbar, Nandkumar Dravid, Karibasappa Gundabaktha Nagappa, Chakor Rokade
INTRODUCTION: Infectious granulomatous dermatitis is a distinctive entity of chronic inflammation. Recognizing the aetiology of granulomatous lesion is challenging to the dermatopathologist. The definitive diagnosis of the granulomatous lesions of skin with identification of aetiological agent is very essential for specific treatment and an appropriate desirable outcome. AIM: To study the histomorphology of various granulomatous lesions of skin and classify them, accordingly into different categories...
November 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28043557/antimycobacterial-potency-and-cytotoxicity-study-of-three-medicinal-plants
#11
Patrick Valere Tsouh Fokou, Regina Appiah-Opong, Dorothy Yeboah-Manu, Abena Adomah Kissi-Twum, Lauve Rachel Tchokouaha Yamthe, Aristide Laurel Mokale Kognou, Phyllis Addo, Fabrice Fekam Boyom, Alexander Kwadwo Nyarko
OBJECTIVE/BACKGROUND: Mycobacterial infections including tuberculosis, leprosy, and buruli ulcer are among the most prevalent, debilitating, and deadly tropical diseases, especially in Sub-Saharan Africa. The development of drug resistance to the currently available drugs and the poor compliance emphasize the need for new chemotherapeutic agents. This study was designed to evaluate the in vitro activity of Cleistopholis patens, Annona reticulata, and Greenwayodendron suaveolens against Mycobacterium smegmatis...
December 2016: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28043490/antimycobacterial-activity-of-medicinal-plants-against-the-causative-agent-of-buruli-ulcer-mycobacterium-ulcerans
#12
R Keumoe, M S Nguembou, F P V Tsouh, D V F Donkeng, D Dize, Y L R Tchokouaha, M C D Jiatsa, F R D Youmsi, B Ngameni, B F Fekam
OBJECTIVE/BACKGROUND: Buruli ulcer, known as necrotizing skin disease caused by Mycobacterium ulcerans, has emerged as the most prevalent mycobacteriosis after leprosy and tuberculosis. Accordingly, it has been classified by the World Health Organization as a neglected disease with high significance in tropical areas, including Cameroon. So far, the control of the disease relies mainly on the rifampin-streptomycin combination. Despite its efficiency, it has shown considerable issues, including availability and side effects...
December 2016: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28042219/unusual-presentation-of-multibacillary-nodular-leprosy
#13
Shweta Raut, Swapna Kanade, Gita Nataraj, Preeti Mehta
Despite India achieving the goal of elimination of leprosy as a public health problem, leprosy is still being transmitted in India. However, due to decreased clinical suspicion of leprosy and atypical case presentations, such cases may be not be diagnosed. We present a case report of an unusual presentation of multibacillary leprosy which presented as nodular lesions. This case report indicates that atypical presentations of leprosy may be missed out by primary care physicians.
January 2017: Journal of Laboratory Physicians
https://www.readbyqxmd.com/read/28038394/increased-il-35-producing-tregs-and-cd19-il-35-cells-are-associated-with-disease-progression-in-leprosy-patients
#14
Mohd Tarique, Chaman Saini, Raza Ali Naqvi, Neena Khanna, D N Rao
BACKGROUND: The clinical forms of leprosy consist of a spectrum that reflects the host's immune response to the M. leprae; it provides an ideal model to study the host pathogen interaction and immunological dysregulation in humans. IL-10 and TGF-β producing Tregs are high in leprosy patients and responsible for immune suppression and M. leprae specific T cells anergy. In leprosy, involvement of IL-35 producing Tregs and Bregs remain unstudied. OBJECTIVE: To study the role of IL-35 producing Tregs and Bregs in the human leprosy...
December 27, 2016: Cytokine
https://www.readbyqxmd.com/read/28027305/evaluation-of-polymerase-chain-reaction-pcr-with-slit-skin-smear-examination-sss-to-confirm-clinical-diagnosis-of-leprosy-in-eastern-nepal
#15
Shraddha Siwakoti, Keshav Rai, Narayan Raj Bhattarai, Sudha Agarwal, Basudha Khanal
BACKGROUND: Detection of Mycobacterium leprae in slit skin smear (SSS) is a gold standard technique for the leprosy diagnosis. Over recent years, molecular diagnosis by using PCR has been increasingly used as an alternative for its diagnosis due to its higher sensitivity. This study was carried out for comparative evaluation of PCR and SSS microscopy in a cohort of new leprosy cases diagnosed in B. P. Koirala Institute of health Sciences, Dharan, Nepal. METHODOLOGY/PRINCIPAL FINDINGS: In this prospective crossectional study, 50 new clinically diagnosed cases of leprosy were included...
December 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28025823/hla-alleles-are-genetic-markers-for-susceptibility-and-resistance-towards-leprosy-in-a-mexican-mestizo-population
#16
Maribel Aguilar-Medina, Monica Escamilla-Tilch, Luis Octavio Frías-Castro, Geovanni Romero-Quintana, Iris Estrada-García, Sergio Estrada-Parra, Julio Granados, Eliakym Arambula Meraz, Guzman Sánchez-Schmitz, Shabaana Abdul Khader, Javier Rangel-Moreno, Rosalío Ramos-Payán
Despite the use of multidrug therapy, leprosy remains endemic in some countries. The association of several human leucocyte antigen (HLA) alleles and gene polymorphisms with leprosy has been demonstrated in many populations, but the major immune contributors associated to the spectrum of leprosy have not been defined yet. In this study, genotyping of HLA-A, -B, -DR, and -DQ alleles was performed in leprosy patients (n = 113) and control subjects (n = 117) from the region with the highest incidence for the disease in México...
December 27, 2016: Annals of Human Genetics
https://www.readbyqxmd.com/read/28011849/leprosy-and-bone-marrow-involvement
#17
P Rastogi, B A Chhabria, S Sreedharanunni, A Pannu, N Varma, S Varma
No abstract text is available yet for this article.
November 15, 2016: QJM: Monthly Journal of the Association of Physicians
https://www.readbyqxmd.com/read/28004652/cutaneous-changes-in-internal-malignancy-study-from-a-tertiary-care-center
#18
Iffat Hassan, Sumaya Zeerak, Sanaullah Kuchay, Safia Bashir, Yasmeen J Bhat, Syed Mubashir, Farhan Rasool, Gousia Sheikh, Peerzada Sajad
BACKGROUND: A wide variety of systemic diseases and internal malignancies have cutaneous manifestations. In the context of internal malignancy, many cutaneous changes are highly specific to the underlying malignancy, while other changes are nonspecific. Some changes are also due to the modalities employed in the treatment of malignancies. METHODS: Two hundred and fifty patients who were diagnosed with internal malignancy and who were attending the department of radiation oncology, were evaluated at the Department of Dermatology, Sexually Transmitted Diseases and Leprosy of Government Medical College, Srinagar...
December 20, 2016: Indian Journal of Dermatology, Venereology and Leprology
https://www.readbyqxmd.com/read/28003920/a-rare-case-of-coexistence-of-borderline-lepromatous-leprosy-with-tuberculosis-verrucosa-cutis
#19
Biswajit Dey, Debasis Gochhait, Nagendran Prabhakaran, Laxmisha Chandrashekar, Biswanath Behera
Occurrence of pulmonary tuberculosis with leprosy is known but association of cutaneous tuberculosis with leprosy is rare. We report a case of borderline lepromatous leprosy coexistent with tuberculosis verrucosa cutis in a 29-year-old male, who presented with multiple skin coloured nodules and hyperkeratotic scaly lesions of 3-month duration. Dual infections are associated with high mortality and morbidity. Therefore early diagnosis and management helps to reduce mortality and to mitigate the effects of morbidity...
2016: Case Reports in Infectious Diseases
https://www.readbyqxmd.com/read/28001229/sociodemographic-and-epidemiological-profile-of-leprosy-patients-in-an-endemic-region-in-brazil
#20
Ronald Jefferson Martins, Maria Emília Oliveira Gomes Carloni, Suzely Adas Saliba Moimaz, Cléa Adas Saliba Garbin, Artênio José Ísper Garbin
INTRODUCTION: The incidence of Hansen's disease is high in overlooked populations. METHODS: Data of Hansen's disease cases reported in the information system of the Department of Informatics, Brazilian Unified Health System, from 2013 to 2014 were analyzed. RESULTS: Among 434 studied cases of Hansen's disease, the female sex (52.5%), adult age (73.7%), low educational level (61.8%), and multibacillary form were associated with higher prevalence rates...
November 2016: Revista da Sociedade Brasileira de Medicina Tropical
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