Amra Ramović Hamzagić, Danijela Cvetković, Marina Gazdić Janković, Nevena Milivojević Dimitrijević, Dalibor Nikolić, Marko Živanović, Nikolina Kastratović, Ivica Petrović, Sandra Nikolić, Milena Jovanović, Dragana Šeklić, Nenad Filipović, Biljana Ljujić
(1) Background: Cancer stem cells (CSCs) are a subpopulation of cells in a tumor that can self-regenerate and produce different types of cells with the ability to initiate tumor growth and dissemination. Chemotherapy resistance, caused by numerous mechanisms by which tumor tissue manages to overcome the effects of drugs, remains the main problem in cancer treatment. The identification of markers on the cell surface specific to CSCs is important for understanding this phenomenon. (2) Methods: The expression of markers CD24, CD44, ALDH1, and ABCG2 was analyzed on the surface of CSCs in two cancer cell lines, MDA-MB-231 and HCT-116, after treatment with 5-fluorouracil (5-FU) using flow cytometry analysis...
February 25, 2024: Current Oncology