keyword
https://read.qxmd.com/read/37693478/ubiquitin-ligase-and-signalling-hub-mycbp2-is-required-for-efficient-ephb2-tyrosine-kinase-receptor-function
#21
Chao Chang, Sara L Banerjee, Sung Soon Park, Xiaolei Zhang, David Cotnoir-White, Muriel Desbois, Brock Grill, Artur Kania
Eph receptor tyrosine kinases participate in a variety of normal and pathogenic processes during development and throughout adulthood. This versatility is likely facilitated by the ability of Eph receptors to signal through diverse cellular signalling pathways: primarily by controlling cytoskeletal dynamics, but also by regulating cellular growth, proliferation, and survival. Despite many proteins linked to these signalling pathways interacting with Eph receptors, the specific mechanisms behind such links and their coordination remain to be elucidated...
August 29, 2023: bioRxiv
https://read.qxmd.com/read/37633457/inhibition-of-the-corest-repressor-complex-promotes-wound-re-epithelialization-via-regulation-of-keratinocyte-migration
#22
JOURNAL ARTICLE
Maki Kida, Iqra Fatima, Elena Rozhkova, Marta Otero-Viñas, Muzhou Wu, Jay H Kalin, Philip A Cole, Vincent Falanga, Rhoda M Alani, Andrey A Sharov
Wound healing is a complex process involving phases of hemostasis, inflammation, proliferation, and remodeling. The regenerative process in the skin requires coordination between many regulators including signaling molecules, transcription factors and the epigenetic machinery. Here we show that chromatin regulators histone deacetylase 1 (HDAC1) and lysine-specific histone demethylase 1 (LSD1), key components of the CoREST repressor complex, are upregulated in the regenerating epidermis during wound repair. We also show that corin, a synthetic dual inhibitor of the CoREST complex and HDAC1/LSD1 activities, significantly accelerates wound closure through enhanced re-epithelialization in a mouse tail wound model...
August 24, 2023: Journal of Investigative Dermatology
https://read.qxmd.com/read/37575018/impaired-erythropoietin-producing-hepatocellular-b-receptors-signaling-in-the-prefrontal-cortex-and-hippocampus-following-maternal-immune-activation-in-male-rats
#23
JOURNAL ARTICLE
Yiqian Shao, Yaqi Cai, Tengfei Chen, Keke Hao, Binbin Luo, Xiujuan Wang, Weiyun Guo, Xi Su, Luxian Lv, Yongfeng Yang, Wenqiang Li
An environmental risk factor for schizophrenia (SZ) is maternal infection, which exerts longstanding effects on the neurodevelopment of offspring. Accumulating evidence suggests that synaptic disturbances may contribute to the pathology of the disease, but the underlying molecular mechanisms remain poorly understood. Erythropoietin-producing hepatocellular B (EphB) receptor signaling plays an important role in synaptic plasticity by regulating the formation and maturation of dendritic spines and regulating excitatory neurotransmission...
August 14, 2023: Genes, Brain, and Behavior
https://read.qxmd.com/read/37514012/computational-modeling-high-level-soluble-expression-and-in-vitro-cytotoxicity-assessment-of-recombinant-pseudomonas-aeruginosa-azurin-a-promising-anti-cancer-therapeutic-candidate
#24
JOURNAL ARTICLE
Shakira Aslam, Hafiz Muzzammel Rehman, Muhammad Zeeshan Sarwar, Ajaz Ahmad, Nadeem Ahmed, Muhammad Imran Amirzada, Hafiz Muhammad Rehman, Humaira Yasmin, Tariq Nadeem, Hamid Bashir
Azurin is a natural protein produced by Pseudomonas aeruginosa that exhibits potential anti-tumor, anti-HIV, and anti-parasitic properties. The current study aimed to investigate the potential of azurin protein against breast cancer using both in silico and in vitro analyses. The amino acid sequence of Azurin was used to predict its secondary and tertiary structures, along with its physicochemical properties, using online software. The resulting structure was validated and confirmed using Ramachandran plots and ERRAT2...
June 26, 2023: Pharmaceutics
https://read.qxmd.com/read/37479851/disrupted-in-schizophrenia-1-reverse-ectopic-migration-of-neural-precursors-in-mouse-hilus-after-pilocarpine-induced-status-epilepticus
#25
JOURNAL ARTICLE
Lu Chen, Jing Xu, Lin Zhu, Puying Xu, Lvhua Chang, Yanbing Han, Qian Wu
Neural precursors in the subgranular zone (SGZ) can be stimulated by status epilepticus (SE) and ectopically migrate to the hilus. These mislocated cells serve as "potential pacemakers" of spontaneous recurrent seizures, and targeting them could potentially reverse the seizure process. Disrupted-in-Schizophrenia 1 (DISC1) regulates hippocampal neurogenesis after seizures both in vitro and in vivo. Our previous study found that DISC1 was colocalized with neural precursors in the hilus after SE. However, its molecular mechanism and pathways contribute to the ectopic migration of neural precursors to the hilus induced by SE awaits exploration...
July 21, 2023: Molecular Neurobiology
https://read.qxmd.com/read/37423317/schedule-induced-alcohol-intake-during-adolescence-sex-dependently-impairs-hippocampal-synaptic-plasticity-and-spatial-memory
#26
JOURNAL ARTICLE
Ana Belén Sanz-Martos, Esmeralda Fuentes-Verdugo, Beatriz Merino, Lidia Morales, Vicente Pérez, Roberto Capellán, Ricardo Pellón, Miguel Miguéns, Nuria Del Olmo
In a previous study, we demonstrated that intermittent ethanol administration in male adolescent animals impaired hippocampus-dependent spatial memory, particularly under conditions of excessive ethanol administration. In this current study, we subjected adolescent male and female Wistar rats an alcohol schedule-induced drinking (SID) procedure to obtain an elevated rate of alcohol self-administration and assessed their hippocampus-dependent spatial memory. We also studied hippocampal synaptic transmission and plasticity, as well as the expression levels of several genes involved in these mechanisms...
July 7, 2023: Behavioural Brain Research
https://read.qxmd.com/read/37401197/ephrin-b-ephb-in-neuropathic-pain-role-and-molecular-mechanisms
#27
REVIEW
Sahibpreet Kaur, Anjana Bali, Nirmal Singh, Amteshwar Singh Jaggi
Ephrins are protein ligands that act through the tyrosine kinase receptor family, Eph receptors. The role of ephrin/Eph in the critical processes involved in the development of the nervous system, including axon guidance and cell migration, has been well documented. Moreover, studies have shown an upregulation of ephrin B1/EphB1 and ephrin B2/EphB2 in neuropathic pain of different etiology. The activation of the ephrin B/EphB system in the dorsal root ganglion and dorsal horn of the spinal cord may be essential in initiating and maintaining neuropathic pain...
July 3, 2023: Fundamental & Clinical Pharmacology
https://read.qxmd.com/read/37382172/the-transcriptional-foundations-of-interferon-%C3%AE-mediated-endometrial-cell-to-uterine-receptivity
#28
JOURNAL ARTICLE
Kezhen Yao, Li Fang, Yu Sun
PROBLEM: Interferon-λ (IFN-λ) is a novel non-redundant regulator that participates in the fetal-maternal immune interaction, including immune regulation, uterine receptivity, cell migration and adhesion, and endometrium apoptosis. However, the exact transcriptional foundation for endometrial signaling of IFN-λ is not completely understood, and studies regarding IFN-λ to implantation failure in vivo are limited. METHOD OF STUDY: The gene expression profile of human endometrial Ishikawa cell line treated with IFN-λ or IFN-α (100 ng/mL) for 6 h was analyzed using RNA-sequencing...
July 2023: American Journal of Reproductive Immunology: AJRI
https://read.qxmd.com/read/37318740/nt-3-combined-with-tgf-%C3%AE-signaling-pathway-enhance-the-repair-of-spinal-cord-injury-by-inhibiting-glial-scar-formation-and-promoting-axonal-regeneration
#29
JOURNAL ARTICLE
Taibang Chen, Xiaoqing He, Jing Wang, Di Du, Yongqing Xu
This study investigated the mechanism of neurotrophin-3 (NT-3) in promoting spinal cord injury repair through the transforming growth factor-beta (TGF-β) signaling pathway. A mouse model of spinal cord injury was established. Forty C57BL/6J mice were randomized into model, NT-3, NT-3 + TGF-β1 and NT-3 + LY364947 groups. The Basso-Beattie-Bresnahan (BBB) scores of the NT-3 and NT-3 + LY364947 groups were significantly higher than the model group. The BBB score of the NT-3 + TGF-β1 group was significantly lower than NT-3 group...
June 15, 2023: Molecular Biotechnology
https://read.qxmd.com/read/37191732/proteomic-profiling-of-retina-and-retinal-pigment-epithelium-combined-embryonic-tissue-to-facilitate-ocular-disease-gene-discovery
#30
JOURNAL ARTICLE
Sandeep Aryal, Deepti Anand, Hongzhan Huang, Ashok P Reddy, Phillip A Wilmarth, Larry L David, Salil A Lachke
To expedite gene discovery in eye development and its associated defects, we previously developed a bioinformatics resource-tool iSyTE (integrated Systems Tool for Eye gene discovery). However, iSyTE is presently limited to lens tissue and is predominantly based on transcriptomics datasets. Therefore, to extend iSyTE to other eye tissues on the proteome level, we performed high-throughput tandem mass spectrometry (MS/MS) on mouse embryonic day (E)14.5 retina and retinal pigment epithelium combined tissue and identified an average of 3300 proteins per sample (n = 5)...
May 16, 2023: Human Genetics
https://read.qxmd.com/read/37162958/the-sequence-basis-for-selectivity-of-ephrin-b2-ligand-for-eph-receptors-and-pathogenic-henipavirus-g-glycoproteins
#31
Krishna K Narayanan, Moushimi Amaya, Natalie Tsang, Randy Yin, Alka Jays, Christopher C Broder, Diwakar Shukla, Erik Procko
UNLABELLED: Ephrin-B2 (EFNB2) is a ligand for six Eph receptors in humans and functions as a cell entry receptor for several henipaviruses including Nipah virus (NiV), a pathogenic zoonotic virus with pandemic potential. To understand the sequence basis of promiscuity for EFNB2 binding to the attachment glycoprotein of NiV (NiV-G) and Eph receptors, we performed deep mutagenesis on EFNB2 to identify mutations that enhance binding to NiV-G over EphB2, one of the highest affinity Eph receptors...
April 26, 2023: bioRxiv
https://read.qxmd.com/read/37092847/the-3d-culturing-of-organoids-from-murine-intestinal-crypts-and-a-single-stem-cell-for-organoid-research
#32
JOURNAL ARTICLE
Yuta Takase, Kazuto Fujishima, Toshio Takahashi
At present, organoid culture represents an important tool for in vitro studies of different biological aspects and diseases in different organs. Murine small intestinal crypts can form organoids that mimic the intestinal epithelium when cultured in a 3D extracellular matrix. The organoids are composed of all cell types that fulfill various intestinal homeostatic functions. These include Paneth cells, enteroendocrine cells, enterocytes, goblet cells, and tuft cells. Well-characterized molecules are added into the culture medium to enrich the intestinal stem cells (ISCs) labeled with leucine-rich repeats containing G protein-coupled receptor 5 and are used to drive differentiation down specific lineages; these molecules include epidermal growth factor, Noggin (a bone morphogenetic protein), and R-spondin 1...
April 7, 2023: Journal of Visualized Experiments: JoVE
https://read.qxmd.com/read/37091977/an-integrated-bioinformatic-analysis-of-bulk-and-single-cell-sequencing-clarifies-immune-microenvironment-and-metabolic-profiles-of-lung-adenocarcinoma-to-predict-immunotherapy-efficacy
#33
JOURNAL ARTICLE
Mengling Li, Baosen Zhou, Chang Zheng
Targeting the tumor microenvironment is increasingly recognized as an effective treatment of advanced lung adenocarcinoma (LUAD). However, few studies have addressed the efficacy of immunotherapy for LUAD. Here, a novel method for predicting immunotherapy efficacy has been proposed, which combines single-cell and bulk sequencing to characterize the immune microenvironment and metabolic profile of LUAD. TCGA bulk dataset was used to cluster two immune subtypes: C1 with "cold" tumor characteristics and C2 with "hot" tumor characteristics, with different prognosis...
2023: Frontiers in Cell and Developmental Biology
https://read.qxmd.com/read/37036605/exosomes-derived-from-ephb2-overexpressing-bone-marrow-mesenchymal-stem-cells-regulate-immune-balance-and-repair-barrier-function
#34
JOURNAL ARTICLE
Si Chu, Ting Yu, Wenzhu Wang, Hui Wu, Feng Zhu, Chunzhu Wei, Fei Gao, Chang Liu, Heng Fan
BACKGROUND: Disruption of intestinal barrier function and an imbalance in intestinal immunity are crucial for the occurrence and development of ulcerative colitis. Because of their important roles in regulating inflammation and immunity, exosomes (Exos) released from bone marrow mesenchymal stem cells (BMSCs) may be useful for treating ulcerative colitis. The EphB/EphrinB signaling pathway plays a crucial role in the inflammatory process and the development and function of immune cells, and can mediate long-distance intercellular communication through extracellular vesicles...
April 10, 2023: Biotechnology Letters
https://read.qxmd.com/read/37023088/development-and-validation-of-a-prognostic-model-for-mitophagy-related-genes-in-colon-adenocarcinoma-a-study-based-on-tcga-and-geo-databases
#35
JOURNAL ARTICLE
Yong Tang, Haiyang Guo, Lin Chen, Xiaobo Wang, Qi Chen, Lei Gou, Xiuyu Liu, Xianfei Wang
BACKGROUND: Mitophagy is used by eukaryotic cells to eliminate damaged mitochondria. The deregulation of this process can lead to an accumulation of dysfunctional mitochondria and is implicated in carcinogenesis and tumorigenesis. Despite increasing evidence that mitophagy is involved in the development of colon cancer, the role of mitophagy-related genes (MRGs) in colon adenocarcinoma (COAD) prognosis and treatment remains largely unknown. METHODS: Differential analysis was used to identify differentially expressed mitophagy-related genes associated with COAD and conduct key module screening...
2023: PloS One
https://read.qxmd.com/read/36993571/proteomic-profiling-of-retina-and-retinal-pigment-epithelium-combined-embryonic-tissue-to-facilitate-ocular-disease-gene-discovery
#36
Sandeep Aryal, Deepti Anand, Hongzhan Huang, Ashok P Reddy, Phillip A Wilmarth, Larry L David, Salil A Lachke
To expedite gene discovery in eye development and its associated defects, we previously developed a bioinformatics resource-tool iSyTE (integrated Systems Tool for Eye gene discovery). However, iSyTE is presently limited to lens tissue and is predominantly based on transcriptomics datasets. Therefore, to extend iSyTE to other eye tissues on the proteome level, we performed high-throughput tandem mass spectrometry (MS/MS) on mouse embryonic day (E)14.5 retina and retinal pigment epithelium combined tissue and identified an average of 3,300 proteins per sample (n=5)...
March 17, 2023: Research Square
https://read.qxmd.com/read/36898846/fusobacterium-nucleatum-induced-exosomal-hottip-promotes-gastric-cancer-progression-through-mir-885-3p-ephb2-axis
#37
JOURNAL ARTICLE
Yiwei Xin, Xinyang Li, Mengjiao Zhang, Ziqi Shang, Zhengdong Luo, Yifeng Wang, Xinru Gui, Qi Liu, Tingting Li, Shunjie Zeng, Helgi B Schiöth, Xin Zhang, Yi Zhang
Recent studies have demonstrated that Fusobacterium nucleatum (Fn) is associated with gastric cancer (GC). Cancer-derived exosomes contain key regulatory non-coding RNAs and are crucial medium of intercellular communication. However, the function and regulatory mechanism of exosomes (Fn-GCEx) secreted from Fn-infected GC cells remains unclear. In this study, Fn-GCEx enhanced the proliferation, migration and invasion capacity of GC cells in vitro, as well as tumor growth and metastasis in vivo. And, HOTTIP was upregulated in GC cells treated with Fn-GCEx...
March 10, 2023: Cancer Science
https://read.qxmd.com/read/36847923/an-investigation-of-binding-interactions-of-tumor-targeted-peptide-conjugated-polyphenols-with-the-kinase-domain-of-ephrin-b4-and-b2-receptors
#38
JOURNAL ARTICLE
Saige M Mitchell, Ryan M Heise, Molly E Murray, Dominic J Lambo, Rachel E Daso, Ipsita A Banerjee
Recent studies have shown that Ephrin receptors may be upregulated in several types of cancers including breast, ovarian and endometrial cancers, making them a target for drug design. In this work, we have utilized a target-hopping approach to design new natural product-peptide conjugates and examined their interactions with the kinase-binding domain of EphB4 and EphB2 receptors. The peptide sequences were generated through point mutations of the known EphB4 antagonist peptide TNYLFSPNGPIA. Their anticancer properties and secondary structures were analyzed computationally...
February 27, 2023: Molecular Diversity
https://read.qxmd.com/read/36834826/neddylation-of-ephb1-regulates-its-activity-and-associates-with-liver-fibrosis
#39
JOURNAL ARTICLE
Rongxin Li, Dan Zhang, Yueqing Han, Ke Chen, Weiran Guo, Yijun Chen, Shuzhen Wang
Liver fibrosis is a pathological process characterized by the excessive synthesis and accumulation of extracellular matrix proteins (ECMs) contributed mainly by the activated hepatic stellate cells (HSCs). Currently, no direct and effective anti-fibrotic agents have been approved for clinical use worldwide. Although the dysregulation of Eph receptor tyrosine kinase EphB2 has been reported to associate with the development of liver fibrosis, the involvement of other Eph family members in liver fibrosis remains underexplored...
February 8, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/36817047/construction-of-cuproptosis%C3%A2-associated-prognostic-signature-in-colon-adenocarcinoma-based-on-bioinformatics-and-rt%C3%A2-qpcr-analysis
#40
JOURNAL ARTICLE
Guang Yang, Haiping Wang, Binlian Sun
Colon adenocarcinoma (COAD) is the most common pathological subtype of colon cancer with a high degree of malignancy. Cuproptosis is a newly discovered copper-dependent cell death pattern distinguished from all the other known programmed cell death. Hence, it can be used as a potential therapeutic target for cancer. The present study aimed to clarify the relationship between cuproptosis and prognosis of COAD. The variations of 12 cuproptosis-associated genes based on 623 patients with COAD were comprehensively identified...
March 2023: Oncology Letters
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