Maki Kida, Iqra Fatima, Elena Rozhkova, Marta Otero-Viñas, Muzhou Wu, Jay H Kalin, Philip A Cole, Vincent Falanga, Rhoda M Alani, Andrey A Sharov
Wound healing is a complex process involving phases of hemostasis, inflammation, proliferation, and remodeling. The regenerative process in the skin requires coordination between many regulators including signaling molecules, transcription factors and the epigenetic machinery. Here we show that chromatin regulators histone deacetylase 1 (HDAC1) and lysine-specific histone demethylase 1 (LSD1), key components of the CoREST repressor complex, are upregulated in the regenerating epidermis during wound repair. We also show that corin, a synthetic dual inhibitor of the CoREST complex and HDAC1/LSD1 activities, significantly accelerates wound closure through enhanced re-epithelialization in a mouse tail wound model...
August 24, 2023: Journal of Investigative Dermatology