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https://www.readbyqxmd.com/read/29624118/ephrinb2-activation-enhances-angiogenesis-reduces-amyloid-%C3%AE-deposits-and-secondary-damage-in-thalamus-at-the-early-stage-after-cortical-infarction-in-hypertensive-rats
#1
Shihui Xing, Nannan Pan, Wei Xu, Jian Zhang, Jingjing Li, Chao Dang, Gang Liu, Zhong Pei, Jinsheng Zeng
Cerebral infarction causes secondary neurodegeneration and angiogenesis in thalamus, which impacts functional recovery after stroke. Here, we hypothesize that activation of ephrinB2 could stimulate angiogenesis and restore the secondary neurodegeneration in thalamus after cerebral infarction. Focal cerebral infarction was induced by middle cerebral artery occlusion (MCAO). Secondary damage, angiogenesis, amyloid-β (Aβ) deposits, levels of ephrinB2 and receptor for advanced glycation end product (RAGE) in the ipsilateral thalamus were determined by immunofluorescence and immunoblot...
January 1, 2018: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/29423241/novel-rare-variations-in-genes-that-regulate-developmental-change-in-n-methyl-d-aspartate-receptor-in-patients-with-schizophrenia
#2
Akane Yoshikawa, Fumichika Nishimura, Aya Inai, Yosuke Eriguchi, Masaki Nishioka, Atsuhiko Takaya, Mamoru Tochigi, Yoshiya Kawamura, Tadashi Umekage, Kayoko Kato, Tsukasa Sasaki, Kiyoto Kasai, Chihiro Kakiuchi
The mechanism underlying the vulnerability to developing schizophrenia (SCZ) during adolescence remains elusive. Hypofunction of N-methyl-d-aspartate receptors (NMDARs) has been implicated in the pathophysiology of SCZ. During development, the composition of synaptic NMDARs dramatically changes from NR2B-containing NMDARs to NR2A-containing NMDARs through the phosphorylation of NR2B S1480 or Y1472 by CDK5, CSNK2A1, and EphB2, which plays a pivotal role in the maturation of neural circuits. We hypothesized that the dysregulation of developmental change in NMDARs could be involved in the onset of SCZ...
2018: Human Genome Variation
https://www.readbyqxmd.com/read/29416088/ephb2-receptor-tyrosine-kinase-promotes-hepatic-fibrogenesis-in-mice-via-activation-of-hepatic-stellate-cells
#3
Patrice N Mimche, Choon M Lee, Sylvie M Mimche, Manoj Thapa, Arash Grakoui, Mark Henkemeyer, Tracey J Lamb
Hepatic fibrosis is the result of an excessive wound-healing response subsequent to chronic liver injury. A feature of liver fibrogenesis is the secretion and deposition of extracellular matrix proteins by activated hepatic stellate cells (HSCs). Here we report that upregulation of EphB2 is a prominent feature of two mouse models of hepatic fibrosis and also observed in humans with liver cirrhosis. EphB2 is upregulated and activated in mouse HSCs following chronic carbon tetrachloride (CCl4) exposure. Moreover, we show that EphB2 deficiency attenuates liver fibrosis and inflammation and this is correlated with an overall reduction in pro-fibrotic markers, inflammatory chemokines and cytokines...
February 7, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29383790/xpnpep3-is-a-novel-transcriptional-target-of-canonical-wnt-%C3%AE-catenin-signalling
#4
Raju Kumar, Viswakalyan Kotapalli, Ashmala Naz, Swarnalata Gowrishankar, Satish Rao, Jonathan R Pollack, Murali Dharan Bashyam
Canonical Wnt/β-catenin signaling plays important roles in embryonic development and adult tissue regeneration while aberrant Wnt activation is the major driver of sporadic colorectal cancer (CRC). Thus, it is important to characterize the complete β-catenin target transcriptome. We previously performed microarray-based mRNA profiling of rectal cancer samples stratified for Wnt status. In addition to AXIN2 and EPHB2, XPNPEP3 transcripts were significantly elevated in tumors exhibiting activated Wnt/β-catenin signaling, validated by Q-PCR...
January 31, 2018: Genes, Chromosomes & Cancer
https://www.readbyqxmd.com/read/29366625/involvement-of-mglur-i-in-ephb-ephrinb-reverse-signaling-activation-induced-retinal-ganglion-cell-apoptosis-in-a-rat-chronic-hypertension-model
#5
Yuan Zhao, Qian Li, Xue-Yan Li, Peng Cui, Feng Gao, Ke Zhu, Ling-Zhu Li, Xing-Huai Sun, Zhongfeng Wang
EphB/ephrinB reverse signaling is involved in retinal ganglion cell (RGC) apoptosis in experimental glaucoma. Here, we further investigated the mechanisms underlying EphB/ephrinB reverse signaling activation induced RGC apoptosis in a rat chronic ocular hypertension (COH) model, using patch-clamp techniques in retinal slices. In COH retinas, RGCs showed higher spontaneous firing frequency and much more depolarized membrane potential as compared to control, which was mimicked by intravitreally injection of EphB2-Fc, an activator of ephrinB2...
March 15, 2018: Brain Research
https://www.readbyqxmd.com/read/29351916/pathways-impacted-by-genomic-alterations-in-pulmonary-carcinoid-tumors
#6
Michael K Asiedu, Charles F Thomas, Jie Dong, Sandra C Schulte, Prasidda Khadka, Zhifu Sun, Farhad Kosari, Jin Jen, Julian Molina, George Vasmatzis, Ray Kuang, Marie Christine Aubry, Ping Yang, Dennis A Wigle
Purpose: Pulmonary carcinoid tumors account for up to 5% of all lung malignancies in adults, comprise 30% of all carcinoid malignancies, and are defined histologically as typical carcinoid (TC) and atypical carcinoid (AC) tumors. The role of specific genomic alterations in the pathogenesis of pulmonary carcinoid tumors remains poorly understood. We sought to identify genomic alterations and pathways that are deregulated in these tumors to find novel therapeutic targets for pulmonary carcinoid tumors. Experimental Design: We performed integrated genomic analysis of carcinoid tumors comprising whole genome and exome sequencing, mRNA expression profiling and SNP genotyping of specimens from normal lung, TC and AC, and small cell lung carcinoma (SCLC) to fully represent the lung neuroendocrine tumor spectrum...
April 1, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29243484/nanopatterns-of-surface-bound-ephrinb1-produce-multivalent-ligand-receptor-interactions-that-tune-ephb2-receptor-clustering
#7
Verónica Hortigüela, Enara Larrañaga, Francesco Cutrale, Anna Seriola, María García-Díaz, Anna Lagunas, Jordi Andilla, Pablo Loza-Alvarez, Josep Samitier, Samuel Ojosnegros, Elena Martínez
Here we present a nanostructured surface able to produce multivalent interactions between surface-bound ephrinB1 ligands and membrane EphB2 receptors. We created ephrinB1 nanopatterns of regular size (<30 nm in diameter) by using self-assembled diblock copolymers. Next, we used a statistically enhanced version of the Number and Brightness technique, which can discriminate-with molecular sensitivity-the oligomeric states of diffusive species to quantitatively track the EphB2 receptor oligomerization process in real time...
January 10, 2018: Nano Letters
https://www.readbyqxmd.com/read/29207174/calcium-channels-are-involved-in-ephb-ephrinb-reverse-signaling%C3%A2-induced-apoptosis-in-a-rat-chronic-ocular-hypertension-model
#8
Lingdan Dong, Xianglin Cheng, Long Zhou, Yanhong Hu
Erythropoietin-producing hepatocyte receptor B (EphB)/ephrinB reverse signaling has been revealed to be activated in chronic ocular hypertension (COH) by increasing the apoptosis of retinal ganglion cells (RGCs). However, the exact mechanism is not well understood. The present study investigated the involvement of Ca2+ channels in the apoptosis of RGCs induced by EphB/ephrinB reverse signaling in a rat CHO model, which was established by cauterizing 3 out of the 4 episcleral veins. The expression levels of four voltage‑gated Ca2+ channel subunits (Cav3...
February 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29167398/perspectives-on-treatment-of-alzheimer-s-disease-a-closer-look-into-ephb2-depletion
#9
Irene van Dijken, Marc van der Vlag, Raquel Flores Hernández, Anne Ross
No abstract text is available yet for this article.
November 22, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29158322/optogenetic-activation-of-ephb2-receptor-in-dendrites-induced-actin-polymerization-by-activating-arg-kinase
#10
Clifford Locke, Kazuya Machida, Yi Wu, Ji Yu
Erythropoietin-producing hepatocellular (Eph) receptors regulate a wide array of developmental processes by responding to cell-cell contacts. EphB2 is well-expressed in the brain and known to be important for dendritic spine development, as well as for the maintenance of the synapses, although the mechanisms of these functions have not been fully understood. Here we studied EphB2's functions in hippocampal neurons with an optogenetic approach, which allowed us to specify spatial regions of signal activation and monitor in real-time the consequences of signal activation...
December 15, 2017: Biology Open
https://www.readbyqxmd.com/read/29059157/ephrinb1-promotes-cancer-cell-migration-and-invasion-through-the-interaction-with-rhogdi1
#11
H J Cho, Y-S Hwang, J Yoon, M Lee, H G Lee, I O Daar
Eph receptors and their corresponding ephrin ligands have been associated with regulating cell-cell adhesion and motility, and thus have a critical role in various biological processes including tissue morphogenesis and homeostasis, as well as pathogenesis of several diseases. Aberrant regulation of Eph/ephrin signaling pathways is implicated in tumor progression of various human cancers. Here, we show that a Rho family GTPase regulator, Rho guanine nucleotide dissociation inhibitor 1 (RhoGDI1), can interact with ephrinB1, and this interaction is enhanced upon binding the extracellular domain of the cognate EphB2 receptor...
October 23, 2017: Oncogene
https://www.readbyqxmd.com/read/29027839/ephb-receptors-mainly-ephb3-contribute-to-the-proper-development-of-cortical-thymic-epithelial-cells
#12
Sara Montero-Herradón, Javier García-Ceca, Agustín G Zapata
EphB and their ligands ephrin-B are an important family of protein tyrosine kinase receptors involved in thymocyte-thymic epithelial cell interactions known to be key for the maturation of both thymic cell components. In the present study, we have analyzed the maturation of cortical thymic epithelium in EphB-deficient thymuses evaluating the relative relevance of EphB2 and EphB3 in the process. Results support a relationship between the epithelial hypocellularity of mutant thymuses and altered development of thymocytes, lower proportions of cycling thymic epithelial cells and increased epithelial cell apoptosis...
October 2, 2017: Organogenesis
https://www.readbyqxmd.com/read/28972287/eps15r-and-clathrin-regulate-ephb2-mediated-cell-repulsion
#13
Emma Evergren, Neville Cobbe, Harvey T McMahon
Expression of Eph receptors and their ligands, the ephrins, have important functions in boundary formation and morphogenesis in both adult and embryonic tissue. The EphB receptors and ephrinB ligands are transmembrane proteins that are expressed in different cells and their interaction drives cell repulsion. For cell repulsion to occur, trans-endocytosis of the inter-cellular receptor-ligand EphB-ephrinB complex is required. The molecular mechanism underlying trans-endocytosis is poorly defined. Here we show that the process is clathrin- and Eps15R-mediated using Co115 colorectal cell lines stably expressing EphB2 and ephrinB1...
January 2018: Traffic
https://www.readbyqxmd.com/read/28936833/-mechanism-of-salvianolate-injection-combined-with-aspirin-in-treatment-of-stable-angina-pectoris-based-on-biomolecules-network
#14
Yuan Li, Lian-Xin Wang, Yan-Ming Xie
Biomolecular network analysis was used to predict the mechanism of Salvianolate injection combined with aspirin for the treatment of stable angina pectoris(SAP). Related genes of Salvianolate injection, aspirin and SAP were obtained from Genecards, STITCH and DisGeNET databases. Agilent literature search software was used to construct biomolecular network; modules were identified by AP, MCODE and MCL methods. DAVID software was used for identification of related KEGG pathways. Results showed that Salvianolate injection and aspirin had a coverage rate of 45...
December 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28931592/ubiquitin-ligase-spsb4-diminishes-cell-repulsive-responses-mediated-by-ephb2
#15
Fumihiko Okumura, Akiko Joo-Okumura, Keisuke Obara, Alexander Petersen, Akihiko Nishikimi, Yoshinori Fukui, Kunio Nakatsukasa, Takumi Kamura
Eph receptor tyrosine kinases and their ephrin ligands are overexpressed in various human cancers, including colorectal malignancies, suggesting important roles in many aspects of cancer development and progression as well as in cellular repulsive responses. The ectodomain of EphB2 receptor is cleaved by metalloproteinases (MMPs) MMP-2/MMP-9 and released into the extracellular space after stimulation by its ligand. The remaining membrane-associated fragment is further cleaved by the presenilin-dependent γ-secretase and releases an intracellular peptide that has tyrosine kinase activity...
November 15, 2017: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/28892054/long-lived-force-patterns-and-deformation-waves-at-repulsive-epithelial-boundaries
#16
Pilar Rodríguez-Franco, Agustí Brugués, Ariadna Marín-Llauradó, Vito Conte, Guiomar Solanas, Eduard Batlle, Jeffrey J Fredberg, Pere Roca-Cusachs, Raimon Sunyer, Xavier Trepat
For an organism to develop and maintain homeostasis, cell types with distinct functions must often be separated by physical boundaries. The formation and maintenance of such boundaries are commonly attributed to mechanisms restricted to the cells lining the boundary. Here we show that, besides these local subcellular mechanisms, the formation and maintenance of tissue boundaries involves long-lived, long-ranged mechanical events. Following contact between two epithelial monolayers expressing, respectively, EphB2 and its ligand ephrinB1, both monolayers exhibit oscillatory patterns of traction forces and intercellular stresses that tend to pull cell-matrix adhesions away from the boundary...
October 2017: Nature Materials
https://www.readbyqxmd.com/read/28800788/mir-204-regulates-cell-proliferation-and-invasion-by-targeting-ephb2-in-human-cervical-cancer
#17
Shanhong Duan, Ali Wu, Zhengyu Chen, Yarong Yang, Liying Liu, Qi Shu
MicroRNAs (miRNAs) are small non-coding RNAs that involved in human carcinogenesis and progression. miR-204 has been reported to be a tumor suppressor in several cancer types. However, the function and underlying molecular mechanism of miR-204 in cervical cancer (CC) are still unclear. In the present study, the expression level of miR-204 was measured using qRT-PCR method in 30 paired CC clinical samples and 6 CC cell lines. We found that the expression of miR-204 was significantly down-regulated in CC tissues and cell lines compared to normal cervical tissues and cell line...
August 11, 2017: Oncology Research
https://www.readbyqxmd.com/read/28781809/a-novel-protein-expression-signature-differentiates-benign-lipomas-from-well-differentiated-liposarcomas
#18
Quang Mather, Jonathon Priego, Kristi Ward, Verma Kundan, Dat Tran, Alok Dwivedi, Brad A Bryan
Benign lipomas and well-differentiated liposarcomas share many histological and molecular features. Due to their similarities, patients with these lipomatous tumors are misdiagnosed up to 40% of the time following radiological detection, up to 17% of the time following histological examination, and in as many as 15% of cases following fluorescent in situ hybridization for chromosomal anomalies. Incorrect classification of these two tumor types leads to increased costs to the patient and delayed accurate diagnoses...
September 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28768156/the-syk-kinases-orchestrate-cerebellar-granule-cell-tangential-migration
#19
Aurélien Benon, Choua Ya, Laurent Martin, Chantal Watrin, Naura Chounlamountri, Iness Jaaoini, Jérôme Honnorat, Véronique Pellier-Monnin, Nelly Noraz
The tyrosine kinases of the Syk family are essential components of the well-characterized immunoreceptor ITAM-based signaling pathway. However, ITAM-based signaling typically does not function in isolation. Instead, it is enmeshed in the molecular network controlling cellular adhesion and chemotaxis. Consistent with the increasing number of data involving ITAM-bearing molecules in neuronal functions, we previously depicted a role for Syk kinases in the establishment of neuronal connectivity. In the developing cerebellum, we found that Syk is essentially expressed in the granule cells (GC) and more importantly, phosphorylated on tyrosine residues representative of an active form of the kinase in tangentially migrating GC...
July 30, 2017: Neuroscience
https://www.readbyqxmd.com/read/28747399/cell-segregation-and-border-sharpening-by-eph-receptor-ephrin-mediated-heterotypic-repulsion
#20
Harriet B Taylor, Anaïs Khuong, Zhonglin Wu, Qiling Xu, Rosalind Morley, Lauren Gregory, Alexei Poliakov, William R Taylor, David G Wilkinson
Eph receptor and ephrin signalling has a major role in cell segregation and border formation, and may act through regulation of cell adhesion, repulsion or tension. To elucidate roles of cell repulsion and adhesion, we combined experiments in cell culture assays with quantitations of cell behaviour which are used in computer simulations. Cells expressing EphB2, or kinase-inactive EphB2 (kiEphB2), segregate and form a sharp border with ephrinB1-expressing cells, and this is disrupted by knockdown of N-cadherin...
July 2017: Journal of the Royal Society, Interface
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