keyword
https://read.qxmd.com/read/38353051/overexpression-of-ephb2-in-the-basolateral-amygdala-is-crucial-for-inducing-visceral-pain-sensitization-in-rats-subjected-to-water-avoidance-stress
#1
JOURNAL ARTICLE
Guang-Bing Duan, Jun-Wen Wang, Hui-Hui Sun, Zhi-Yu Dong, Yan Zhang, Zhen-Xiang Wang, Ye Chen, Ying Chen, Ying Huang, Shu-Chang Xu
AIMS: Basolateral amygdala (BLA), as a center for stress responses and emotional regulation, is involved in visceral hypersensitivity of irritable bowel syndrome (IBS) induced by stress. In the present study, we aimed to investigate the role of EphB2 receptor (EphB2) in BLA and explore the underlying mechanisms in this process. METHODS: Visceral hypersensitivity was induced by water avoidance stress (WAS). Elevated plus maze test, forced swimming test, and sucrose preference test were applied to assess anxiety- and depression-like behaviors...
February 2024: CNS Neuroscience & Therapeutics
https://read.qxmd.com/read/38338684/prognostic-markers-in-tyrosine-kinases-specific-to-basal-like-2-subtype-of-triple-negative-breast-cancer
#2
JOURNAL ARTICLE
Praopim Limsakul, Pongsakorn Choochuen, Thawirasm Jungrungrueang, Krit Charupanit
Triple-negative breast cancer (TNBC), a heterogeneous and therapeutically challenging subtype, comprises over 50% of patients categorized into basal-like 1 (BL1) and basal-like 2 (BL2) intrinsic molecular subtypes. Despite their shared basal-like classification, BL2 is associated with a poor response to neoadjuvant chemotherapy and reduced relapse-free survival compared to BL1. Here, the study focused on identifying subtype-specific markers for BL2 through transcriptomic analysis of TNBC patients using RNA-seq and clinical integration...
January 24, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38295544/ephb2-promotes-enteric-nitrergic-hyperinnervation-and-neurogenic-inflammation-in-dss-induced-chronic-colitis-in-mice
#3
JOURNAL ARTICLE
Yuhua Chen, Chao Huang, Fan Du, Zhuanglong Xiao, Wei Qian, Tao Bai, Jun Song, Yuhu Song, Xiaohua Hou, Lei Zhang
BACKGROUND: Enteric nervous system (ENS) has been closely associated with the neuro-immune response and is currently considered a reliable target for intestinal inflammation. Neuronal nitric oxide synthase (nNOS) nerves are involved in inflammatory diseases by releasing nitric oxide (NO). EphB2 expression and density of innervation of the mucosal layer are positively correlated with the severity of intestinal inflammatory responses. In this study, we hypothesized that a EphB2-mediated mechanism may regulate enteric immunity through modulation of nNOS nerves...
January 30, 2024: International Immunopharmacology
https://read.qxmd.com/read/38289221/ubiquitin-ligase-and-signalling-hub-mycbp2-is-required-for-efficient-ephb2-tyrosine-kinase-receptor-function
#4
JOURNAL ARTICLE
Chao Chang, Sara L Banerjee, Sung Soon Park, Xiao Lei Zhang, David Cotnoir-White, Karla J Opperman, Muriel Desbois, Brock Grill, Artur Kania
Eph receptor tyrosine kinases participate in a variety of normal and pathogenic processes during development and throughout adulthood. This versatility is likely facilitated by the ability of Eph receptors to signal through diverse cellular signalling pathways: primarily by controlling cytoskeletal dynamics, but also by regulating cellular growth, proliferation, and survival. Despite many proteins linked to these signalling pathways interacting with Eph receptors, the specific mechanisms behind such links and their coordination remain to be elucidated...
January 30, 2024: ELife
https://read.qxmd.com/read/38286348/ephb2-as-a-key-mediator-of-glioma-progression-insights-from-microenvironmental-receptor-ligand-related-prognostic-gene-signature
#5
JOURNAL ARTICLE
Liming Tan, Jingyuan Zhou, Zhenyu Nie, Ding Li, Bing Wang
Malignant gliomas, characterized by pronounced heterogeneity, a complex microenvironment, and a propensity for relapse and drug resistaniguree, pose significant challenges in oncology. This study aimed to investigate the prognostic value of Ligand and Receptor related genes (LRRGs) within the glioma microenvironment. An intersection of 71 ligand-related genes (LRGs) and 2628 receptor-related genes (RRGs) yielded a total of 69 LRRGs. Utilizing the least absolute shrinkage and selection operator (LASSO) regression analysis, a prognostic RiskScore model comprising 28 LRRGs was constructed...
January 27, 2024: Genomics
https://read.qxmd.com/read/38264851/twin-study-genotype-dependent-epigenetic-factors-affecting-free-thyroxine-levels-in-the-normal-range
#6
JOURNAL ARTICLE
Saki Yoshioka, Yuya Arakawa, Mika Hasegawa, Shiho Kato, Hinako Hashimoto, Saho Mori, Hiromichi Ueda, Mikio Watanabe
Aim: To explore the clinical application of DNA methylation affecting thyroid function, we evaluated the association of DNA methylation with free thyroxine (FT4) and TSH measurements in monozygotic twins. Materials & methods: Discordant pairs for FT4 or TSH levels were examined for the relationship between the within-pair difference of each measurement and the DNA methylation levels using epigenome-wide association studies. The contribution of polymorphisms to the methylation sensitivity was also examined...
January 24, 2024: Epigenomics
https://read.qxmd.com/read/38252844/contrasting-effects-of-cancer-associated-mutations-in-epha3-and-ephb2-kinases
#7
JOURNAL ARTICLE
Yunyoung Kim, W Todd Miller
Erythropoietin-producing hepatoma (Eph) receptors are a family of tyrosine kinases that can act as tumor promoters or tumor suppressors, depending on the receptor and cancer cell type. Cancer-associated somatic mutations have been identified in all Eph receptors, but in most cases, the functional effects of the mutations are unknown. In this study, we expressed and purified the kinase domains of wild-type (WT) EphA3 and EphB2 along with 16 cancer-associated mutants. We identified mutations that decrease EphA3 activity and both activating and inhibitory mutations in EphB2...
January 22, 2024: Biochemistry
https://read.qxmd.com/read/38233755/whole-genome-resequencing-of-major-populations-revealed-domestication-related-genes-in-yaks
#8
JOURNAL ARTICLE
Wei Peng, Changqi Fu, Shi Shu, Guowen Wang, Hui Wang, Binglin Yue, Ming Zhang, Xinrui Liu, Yaxin Liu, Jun Zhang, Jincheng Zhong, Jiabo Wang
BACKGROUND: The yak is a symbol of the Qinghai-Tibet Plateau and provides important basic resources for human life on the plateau. Domestic yaks have been subjected to strong artificial selection and environmental pressures over the long-term. Understanding the molecular mechanisms of phenotypic differences in yak populations can reveal key functional genes involved in the domestication process and improve genetic breeding. MATERIAL AND METHOD: Here, we re-sequenced 80 yaks (Maiwa, Yushu, and Huanhu populations) to identify single-nucleotide polymorphisms (SNPs) as genetic variants...
January 17, 2024: BMC Genomics
https://read.qxmd.com/read/38114003/interaction-between-the-ephb2-receptor-and-efnb1-ligand-drives-gastric-cancer-invasion-and-metastasis-via-the-wnt-%C3%AE-catenin-fak-pathway
#9
JOURNAL ARTICLE
Yaohua Hu, Qinghua Xie, Jumei Zhao, Runze Yang, Jing Qin, Hui Li, Yong Zhao, Xiong Du, Changhong Shi
The survival benefit for patients with gastric cancer (GC) is modest due to its high transfer potential. Targeted therapy for metastasis-related genes in GC may be a viable approach, however, inhibitors specifically targeting GC are limited. In this study, GC patient-derived xenografts (PDX) with metastatic burden were established via orthotopic transplantation. PCR-Array analysis of primary and metastatic tumors revealed EPH receptor B2 (EPHB2) as the most significantly upregulated gene. The interaction between the EPHB2 receptor and its cognate-specific EFNB1 ligands was high in GC and correlated with a poor prognosis...
December 17, 2023: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38044379/genome-wide-association-study-for-reproduction-traits-in-colombian-creole-blanco-orejinegro-cattle
#10
JOURNAL ARTICLE
Ana Cristina Herrera Rios, Sindy Liliana Caivio Nasner, Marisol Londoño-Gil, Luis Gabriel Gonzalez-Herrera, Albeiro Lopez-Herrera, Juan Carlos Rincón Flórez
The profitability of the beef cattle production system relies heavily on reproductive traits. Unfortunately, certain traits, such as age at first calving (AFC), calving interval (CI), and gestation length (GL), can pose challenges in traditional breeding programs because of their low heritability (0.01-0.12) and sex-limited characteristics. Another important aspect is the conservation of the genetic resources of animals adapted to the Colombian regions, which implies the preservation and rational use of the creole breeds in the country market...
December 4, 2023: Tropical Animal Health and Production
https://read.qxmd.com/read/37985568/effects-of-mir-204-5p-and-target-gene-ephb2-on-cognitive-impairment-induced-by-aluminum-exposure-in-rats
#11
JOURNAL ARTICLE
Wei Liu, Jie Gao, Niping Hao, Jing Li, Jing Pei, Danfeng Zou, Shuo Yang, Yuhua Yin, Xiaoming Yang, Ping Mu, Lifeng Zhang
Aluminum is a common environmental neurotoxin. Aluminum ions can cross the blood-brain barrier and accumulate in different brain regions, damage brain tissue, and cause cognitive impairment, but the molecular mechanism of aluminum neurotoxicity is not precise. This study investigated the effects of miR-204-5p, target gene EphB2, and downstream signaling pathway NMDAR-ERK-CREB-Arc on cognitive dysfunction induced by aluminum exposure. The results showed that the learning and memory of the rats were impaired in behavior...
November 20, 2023: Biological Trace Element Research
https://read.qxmd.com/read/37980331/the-long-non-coding-rna-taz-as202-promotes-lung-cancer-progression-via-regulation-of-the-e2f1-transcription-factor-and-activation-of-ephrin-signaling
#12
JOURNAL ARTICLE
Giulia Gobbi, Alessandra Grieco, Federica Torricelli, Elisabetta Sauta, Giacomo Santandrea, Eleonora Zanetti, Valentina Fantini, Francesca Reggiani, Silvia Strocchi, Massimiliano Paci, Manik Vohra, Srinivas Vinod Saladi, Davide Carlo Ambrosetti, Alessia Ciarrocchi, Valentina Sancisi
Long non-coding RNAs (lncRNAs) are transcripts without coding potential that are pervasively expressed from the genome and have been increasingly reported to play crucial roles in all aspects of cell biology. They have been also heavily implicated in cancer development and progression, with both oncogenic and tumor suppressor functions. In this work, we identified and characterized a novel lncRNA, TAZ-AS202, expressed from the TAZ genomic locus and exerting pro-oncogenic functions in non-small cell lung cancer...
November 18, 2023: Cell Death & Disease
https://read.qxmd.com/read/37949219/fosl1-modulates-schwann-cell-responses-in-the-wound-microenvironment-and-regulates-peripheral-nerve-regeneration
#13
JOURNAL ARTICLE
Qianqian Chen, Lan Zhang, Fuchao Zhang, Sheng Yi
Peripheral glial Schwann cells switch to a repair state after nerve injury, proliferate to supply lost cell population, migrate to form regeneration tracks, and contribute to the generation of a permissive microenvironment for nerve regeneration. Exploring essential regulators of the repair responses of Schwann cells may benefit the clinical treatment for peripheral nerve injury. In the present study, we find that FOSL1, a AP-1 member that encodes transcription factor FOS Like 1, is highly expressed at the injured sites following peripheral nerve crush...
November 8, 2023: Journal of Biological Chemistry
https://read.qxmd.com/read/37946211/m2-macrophage-derived-cathepsin-s-promotes-peripheral-nerve-regeneration-via-fibroblast-schwann-cell-signaling-relay
#14
JOURNAL ARTICLE
Eri Oshima, Yoshinori Hayashi, Zhen Xie, Hitoshi Sato, Suzuro Hitomi, Ikuko Shibuta, Kentaro Urata, Junjun Ni, Koichi Iwata, Tatsuo Shirota, Masamichi Shinoda
BACKGROUND: Although peripheral nerves have an intrinsic self-repair capacity following damage, functional recovery is limited in patients. It is a well-established fact that macrophages accumulate at the site of injury. Numerous studies indicate that the phenotypic shift from M1 macrophage to M2 macrophage plays a crucial role in the process of axon regeneration. This polarity change is observed exclusively in peripheral macrophages but not in microglia and CNS macrophages. However, the molecular basis of axonal regeneration by M2 macrophage is not yet fully understood...
November 9, 2023: Journal of Neuroinflammation
https://read.qxmd.com/read/37931130/sequence-basis-for-selectivity-of-ephrin-b2-ligand-for-eph-receptors-and-pathogenic-henipavirus-g-glycoproteins
#15
JOURNAL ARTICLE
Krishna K Narayanan, Moushimi Amaya, Natalie Tsang, Randy Yin, Alka Jays, Christopher C Broder, Diwakar Shukla, Erik Procko
Ephrin-B2 (EFNB2) is a ligand for six Eph receptors in humans and functions as a cell entry receptor for several henipaviruses including the Nipah virus (NiV), a pathogenic zoonotic virus with pandemic potential. To understand the sequence basis of promiscuity for EFNB2 binding to the attachment glycoprotein of NiV (NiV-G) and Eph receptors, we performed deep mutagenesis on EFNB2 to identify mutations that enhance binding to NiV-G over EphB2, one of the highest affinity Eph receptors. The mutations highlight how different EFNB2 conformations are selected by NiV-G versus EphB2...
October 16, 2023: Journal of Virology
https://read.qxmd.com/read/37910792/molecular-determinants-of-epha2-and-ephb2-antagonism-enable-the-design-of-ligands-with-improved-selectivity
#16
JOURNAL ARTICLE
Lorenzo Guidetti, Alfonso Zappia, Laura Scalvini, Francesca Romana Ferrari, Carmine Giorgio, Riccardo Castelli, Francesca Galvani, Federica Vacondio, Silvia Rivara, Marco Mor, Chiara Urbinati, Marco Rusnati, Massimiliano Tognolini, Alessio Lodola
With the aim of identifying novel antagonists selective for the EphA receptor family, a combined experimental and computational approach was taken to investigate the molecular basis of the recognition between a prototypical Eph-ephrin antagonist (UniPR1447) and two representative receptors of the EphA and EphB subfamilies, namely, EphA2 and EphB2 receptors. The conformational free-energy surface (FES) of the binding state of UniPR1447 within the ligand binding domain of EphA2 and EphB2, reconstructed from molecular dynamics (MD) simulations performed on the microsecond time scale, was exploited to drive the design and synthesis of a novel antagonist selective for EphA2 over the EphB2 receptor...
November 1, 2023: Journal of Chemical Information and Modeling
https://read.qxmd.com/read/37906644/il-38-regulates-intestinal-stem-cell-homeostasis-by-inducing-wnt-signaling-and-beneficial-il-1%C3%AE-secretion
#17
JOURNAL ARTICLE
Alberto Dinarello, Makenna May, Jesus Amo-Aparicio, Tania Azam, Joseph M Gaballa, Carlo Marchetti, Annachiara Tesoriere, Rachele Ghirardo, Jasmina S Redzic, William S Webber, Shaikh M Atif, Suzhao Li, Elan Z Eisenmesser, Dennis M de Graaf, Charles A Dinarello
The IL-1 Family member IL-38 has been characterized primarily as an antiinflammatory cytokine in human and mouse models of systemic diseases. Here, we examined the role of IL-38 in the murine small intestine (SI). Immunostaining of SI revealed that IL-38 expression partially confines to intestinal stem cells. Cultures of intestinal organoids reveal IL-38 functions as a growth factor by increasing organoid size via inducing WNT3a. In contrast, organoids from IL-38-deficient mice develop more slowly. This reduction in size is likely due to the downregulation of intestinal stemness markers (i...
November 7, 2023: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/37864909/mirna-transcriptomics-analysis-shows-mir-483-5p-and-mir-503-5p-targeted-mirna-in-extracellular-vesicles-from-severe-acute-pancreatitis-associated-lung-injury-patients
#18
JOURNAL ARTICLE
Yicheng Xiong, Xiangyang Chen, Xiaodan Yang, Hang Zhang, Xinmiao Li, Zilu Wang, Sizhe Feng, Wen Wen, Xiangqing Xiong
AIM: This study sought to identify potential biomarkers and miRNA-mRNA networks within extracellular vesicles (EVs) for detecting severe acute pancreatitis-associated lung injury (SAPALI). METHODS: Blood-derived EVs were isolated, and their miRNA transcriptomic profiles were comprehensively analyzed using miRBase v.21 database along with miRDeep2 tool to predict novel miRNAs. DEGseq R package was deployed for the identification of differentially expressed miRNAs (DEMs)...
October 19, 2023: International Immunopharmacology
https://read.qxmd.com/read/37862381/surfaceome-analysis-of-extracellular-vesicles-from-senescent-cells-uncovers-uptake-repressor-dpp4
#19
JOURNAL ARTICLE
Qiong Meng, Chen Chen, Na Yang, Olesia Gololobova, Changyou Shi, Christopher A Dunn, Martina Rossi, Jennifer L Martindale, Nathan Basisty, Jun Ding, Michael Delannoy, Srikanta Basu, Krystyna Mazan-Mamczarz, Chang Hoon Shin, Jen-Hao Yang, Peter F Johnson, Kenneth W Witwer, Arya Biragyn, Payel Sen, Kotb Abdelmohsen, Supriyo De, Myriam Gorospe
Senescent cells are beneficial for repairing acute tissue damage, but they are harmful when they accumulate in tissues, as occurs with advancing age. Senescence-associated extracellular vesicles (S-EVs) can mediate cell-to-cell communication and export intracellular content to the microenvironment of aging tissues. Here, we studied the uptake of EVs from senescent cells (S-EVs) and proliferating cells (P-EVs) and found that P-EVs were readily taken up by proliferating cells (fibroblasts and cervical cancer cells) while S-EVs were not...
October 24, 2023: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/37719713/interactions-between-genes-involved-in-physiological-dysregulation-and-axon-guidance-role-in-alzheimer-s-disease
#20
JOURNAL ARTICLE
Konstantin G Arbeev, Svetlana Ukraintseva, Olivia Bagley, Hongzhe Duan, Deqing Wu, Igor Akushevich, Eric Stallard, Alexander Kulminski, Kaare Christensen, Mary F Feitosa, Jeffrey R O'Connell, Daniel Parker, Heather Whitson, Anatoliy I Yashin
Dysregulation of physiological processes may contribute to Alzheimer's disease (AD) development. We previously found that an increase in the level of physiological dysregulation (PD) in the aging body is associated with declining resilience and robustness to major diseases. Also, our genome-wide association study found that genes associated with the age-related increase in PD frequently represented pathways implicated in axon guidance and synaptic function, which in turn were linked to AD and related traits (e...
2023: Frontiers in Genetics
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