Qiong Meng, Chen Chen, Na Yang, Olesia Gololobova, Changyou Shi, Christopher A Dunn, Martina Rossi, Jennifer L Martindale, Nathan Basisty, Jun Ding, Michael Delannoy, Srikanta Basu, Krystyna Mazan-Mamczarz, Chang Hoon Shin, Jen-Hao Yang, Peter F Johnson, Kenneth W Witwer, Arya Biragyn, Payel Sen, Kotb Abdelmohsen, Supriyo De, Myriam Gorospe
Senescent cells are beneficial for repairing acute tissue damage, but they are harmful when they accumulate in tissues, as occurs with advancing age. Senescence-associated extracellular vesicles (S-EVs) can mediate cell-to-cell communication and export intracellular content to the microenvironment of aging tissues. Here, we studied the uptake of EVs from senescent cells (S-EVs) and proliferating cells (P-EVs) and found that P-EVs were readily taken up by proliferating cells (fibroblasts and cervical cancer cells) while S-EVs were not...
October 24, 2023: Proceedings of the National Academy of Sciences of the United States of America