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https://www.readbyqxmd.com/read/28489485/igf-1-mediates-ephrinb1-activation-in-regulating-tertiary-dentin-formation
#1
S Matsumura, A Quispe-Salcedo, C M Schiller, J S Shin, B M Locke, S Yakar, E Shimizu
Eph receptors belong to a subfamily of receptor tyrosine kinases that are activated by membrane-spanning ligands called ephrins. Previously, we demonstrated that the ephrinB1-EphB2 interaction regulates odontogenic/osteogenic differentiation from dental pulp cells (DPCs) in vitro. The goal of this study was to identify the molecular mechanisms regulated by the EphB2/ephrinB1 system that govern tertiary dentin formation in vitro and in vivo. During tooth development, ephrinB1, and EphB2 were expressed in preodontoblast and odontoblasts at postnatal day 4...
May 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28414763/enhanced-offspring-predisposition-to-steatohepatitis-with-maternal-high-fat-diet-is-associated-with-epigenetic-and-microbiome-alterations
#2
Umesh D Wankhade, Ying Zhong, Ping Kang, Maria Alfaro, Sree V Chintapalli, Keshari M Thakali, Kartik Shankar
OBJECTIVE: Non-alcoholic fatty liver disease (NAFLD) is an important co-morbidity associated with obesity and a precursor to steatohepatitis. However, the contributions of gestational and early life influences on development of NAFLD and NASH remain poorly appreciated. METHODS: Two independent studies were performed to examine whether maternal over-nutrition via exposure to high fat diet (HFD) leads to exacerbated hepatic responses to post-natal HFD and methionine choline deficient (MCD) diets in the offspring...
2017: PloS One
https://www.readbyqxmd.com/read/28386563/the-effect-of-phototherapy-on-cancer-predisposition-genes-of-diabetic-and-normal-human-skin-fibroblasts
#3
Pongsathorn Chotikasemsri, Boonsin Tangtrakulwanich, Surasak Sangkhathat
The purpose of this study was to investigate whether LED light at different wavelengths affects the expression profile of 143 cancer predisposition genes in both diabetic and normal human fibroblasts. In this study, both diabetic and normal fibroblast cell lines were cultured and irradiated with red (635 nm), green (520 nm), and blue (465 nm) LED light for 10 minutes at 0.67 J/cm(2) each. After that, mRNA from all cell lines was extracted for microarray analysis. We found that green light activates EPHB2, KIT, ANTXR2, ESCO2, MSR1, EXT1, TSC1, KIT, NF1, BUB1B, FANCD2, EPCAM, FANCD2, NF, DIS3L2, and RET in normal fibroblast cells, while blue and red light can upregulate RUNX1, PDGFRA, EHBP1, GPC3, AXIN2, KDR, GLMN, MSMB, EPHB2, MSR1, KIT, FANCD2, BMPR1A, BUB1B, PDE11A, and RET...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28360821/combined-ephb2-receptor-knockdown-with-radiation-decreases-cell-viability-and-invasion-in-medulloblastoma
#4
Shilpa Bhatia, Kellen Hirsch, Sanjana Bukkapatnam, Nimrah A Baig, Ayman Oweida, Anastacia Griego, Dylan Calame, Jaspreet Sharma, Andrew Donson, Nicholas Foreman, Christopher Albanese, Sujatha Venkataraman, Rajeev Vibhakar, Sana D Karam
BACKGROUND: Medulloblastoma is one of the most common types of pediatric brain tumor characterized by the subpopulation of cells that exhibit high invasive potential and radioresistant properties. In addition, dysregulated function and signaling by Eph family of receptors have been shown to impart pro-tumorigenic characteristics in this brain malignancy. In the current study, we investigated whether EphB2 knockdown in combination with radiation can alter invasiveness and decrease medulloblastoma tumor growth or viability in vitro...
2017: Cancer Cell International
https://www.readbyqxmd.com/read/28358367/overexpression-of-ephb2-in-hippocampus-rescues-impaired-nmda-receptors-trafficking-and-cognitive-dysfunction-in-alzheimer-model
#5
Rui Hu, Pan Wei, Lu Jin, Teng Zheng, Wen-Yu Chen, Xiao-Ya Liu, Xiao-Dong Shi, Jing-Ru Hao, Nan Sun, Can Gao
Alzheimer's disease (AD) is a progressive neurodegenerative disease, which affects more and more people. But there is still no effective treatment for preventing or reversing the progression of the disease. Soluble amyloid-beta (Aβ) oligomers, also known as Aβ-derived diffusible ligands (ADDLs) play an important role in AD. Synaptic activity and cognition critically depend on the function of glutamate receptors. Targeting N-methyl-D-aspartic acid (NMDA) receptors trafficking and its regulation is a new strategy for AD early treatment...
March 30, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28276447/ascl1-promotes-tangential-migration-and-confines-migratory-routes-by-induction-of-ephb2-in-the-telencephalon
#6
Yuan-Hsuan Liu, Jin-Wu Tsai, Jia-Long Chen, Wan-Shan Yang, Pei-Ching Chang, Pei-Lin Cheng, David L Turner, Yuchio Yanagawa, Tsu-Wei Wang, Jenn-Yah Yu
During development, cortical interneurons generated from the ventral telencephalon migrate tangentially into the dorsal telencephalon. Although Achaete-scute family bHLH transcription factor 1 (Ascl1) plays important roles in the developing telencephalon, whether Ascl1 regulates tangential migration remains unclear. Here, we found that Ascl1 promoted tangential migration along the ventricular zone/subventricular zone (VZ/SVZ) and intermediate zone (IZ) of the dorsal telencephalon. Distal-less homeobox 2 (Dlx2) acted downstream of Ascl1 in promoting tangential migration along the VZ/SVZ but not IZ...
March 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28041973/prognostic-significance-of-stromal-grem1-expression-in-colorectal-cancer
#7
Bo Gun Jang, Hye Sung Kim, Weon Young Chang, Jeong Mo Bae, Hyeon Jeong Oh, Xianyu Wen, Seorin Jeong, Nam Yun Cho, Woo Ho Kim, Gyeong Hoon Kang
Cancer-associated fibroblasts are the dominant cell population in the cancer stroma. Gremlin 1 (GREM1), an antagonist of the bone morphogenetic protein pathway, is expressed by cancer-associated fibroblasts in a variety of human cancers. However, its biological significance for cancer patients is largely unknown. We applied RNA in situ hybridization to evaluate the prognostic value of stromal GREM1 expression in a large cohort of 670 colorectal cancers (CRCs). Overall, GREM1 expression in CRCs was lower than that of the matched normal mucosa, and GREM1 expression had a strong positive correlation with BMI1 and inverse correlations with EPHB2 and OLFM4...
April 2017: Human Pathology
https://www.readbyqxmd.com/read/27881781/blocking-the-interaction-between-ephb2-and-addls-by-a-small-peptide-rescues-impaired-synaptic-plasticity-and-memory-deficits-in-a-mouse-model-of-alzheimer-s-disease
#8
Xiao-Dong Shi, Kai Sun, Rui Hu, Xiao-Ya Liu, Qiu-Mei Hu, Xiao-Yu Sun, Bin Yao, Nan Sun, Jing-Ru Hao, Pan Wei, Yuan Han, Can Gao
Soluble amyloid-β (Aβ) oligomers, also known as Aβ-derived diffusible ligands (ADDLs), are thought to be the key pathogenic factor in Alzheimer's disease (AD), but there is still no effective treatment for preventing or reversing the progression of the disease. Targeting NMDA receptor trafficking and regulation is a new strategy for early treatment of AD. Aβ oligomers have been found to bind to the fibronectin (FN) type III repeat domain of EphB2 to trigger EphB2 degradation, thereby impairing the normal functioning of NMDA receptors and resulting in cognitive deficits...
November 23, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27833077/anti-egfr-antibody-sensitizes-colorectal-cancer-stem-like-cells-to-fluorouracil-induced-apoptosis-by-affecting-autophagy
#9
Ye Feng, Shuohui Gao, Yongjian Gao, Xuefeng Wang, Zhi Chen
Recent reports suggest that colorectal carcinoma (CRC) may be sustained by a small subpopulation of cells, termed cancer stem cells (CSCs), which have drug resistance properties as a key reason for chemotherapy failure. The epidermal growth factor receptor (EGFR) controls CRC initiation and progression. Monoclonal antibody against EGFR (cetuximab) has been used in treatment of several cancers. However, the effects of cetuximab on CSCs in the CRC chemotherapy remain unclear. Here, we studied the effects of cetuximab on the CSC-like cells in Fluorouracil (5-FU)-treated CRC cells...
December 6, 2016: Oncotarget
https://www.readbyqxmd.com/read/27799372/correction-tiam-rac-signaling-mediates-trans-endocytosis-of-ephrin-receptor-ephb2-and-is-important-for-cell-repulsion
#10
Thomas N Gaitanos, Jorg Koerner, Ruediger Klein
No abstract text is available yet for this article.
October 31, 2016: Journal of Cell Biology
https://www.readbyqxmd.com/read/27748801/acquisition-of-anticancer-drug-resistance-is-partially-associated-with-cancer-stemness-in-human-colon-cancer-cells
#11
Flaria El Khoury, Laurent Corcos, Stéphanie Durand, Brigitte Simon, Catherine Le Jossic-Corcos
Colorectal cancer (CRC) is one of the most aggressive cancers worldwide. Several anticancer agents are available to treat CRC, but eventually cancer relapse occurs. One major cause of chemotherapy failure is the emergence of drug-resistant tumor cells, suspected to originate from the stem cell compartment. The aim of this study was to ask whether drug resistance was associated with the acquisition of stem cell-like properties. We isolated drug-resistant derivatives of two human CRC cell lines, HT29 and HCT116, using two anticancer drugs with distinct modes of action, oxaliplatin and docetaxel...
December 2016: International Journal of Oncology
https://www.readbyqxmd.com/read/27683910/amygdala-ephb2-signaling-regulates-glutamatergic-neuron-maturation-and-innate-fear
#12
Xiao-Na Zhu, Xian-Dong Liu, Hanyi Zhuang, Mark Henkemeyer, Jing-Yu Yang, Nan-Jie Xu
UNLABELLED: The amygdala serves as emotional center to mediate innate fear behaviors that are reflected through neuronal responses to environmental aversive cues. However, the molecular mechanism underlying the initial neuron responses is poorly understood. In this study, we monitored the innate defensive responses to aversive stimuli of either elevated plus maze or predator odor in juvenile mice and found that glutamatergic neurons were activated in amygdala. Loss of EphB2, a receptor tyrosine kinase expressed in amygdala neurons, suppressed the reactions and led to defects in spine morphogenesis and fear behaviors...
September 28, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27617966/anti-ephrin-type-b-receptor-2-ephb2-and-anti-three-prime-histone-mrna-exonuclease-1-thex1-autoantibodies-in-scleroderma-and-lupus
#13
Doua F Azzouz, Gabriel V Martin, Fanny Arnoux, Nathalie Balandraud, Thierry Martin, Sylvain Dubucquoi, Eric Hachulla, Dominique Farge-Bancel, Kiet Tiev, Jean Cabane, Nathalie Bardin, Laurent Chiche, Marielle Martin, Eléonore C Caillet, Sami B Kanaan, Jean Robert Harlé, Brigitte Granel, Elisabeth Diot, Jean Roudier, Isabelle Auger, Nathalie C Lambert
In a pilot ProtoArray analysis, we identified 6 proteins out of 9483 recognized by autoantibodies (AAb) from patients with systemic sclerosis (SSc). We further investigated the 6 candidates by ELISA on hundreds of controls and patients, including patients with Systemic Lupus Erythematosus (SLE), known for high sera reactivity and overlapping AAb with SSc. Only 2 of the 6 candidates, Ephrin type-B receptor 2 (EphB2) and Three prime Histone mRNA EXonuclease 1 (THEX1), remained significantly recognized by sera samples from SSc compared to controls (healthy or with rheumatic diseases) with, respectively, 34% versus 14% (P = 2...
2016: PloS One
https://www.readbyqxmd.com/read/27597758/tiam-rac-signaling-mediates-trans-endocytosis-of-ephrin-receptor-ephb2-and-is-important-for-cell-repulsion
#14
Thomas N Gaitanos, Jorg Koerner, Ruediger Klein
Ephrin receptors interact with membrane-bound ephrin ligands to regulate contact-mediated attraction or repulsion between opposing cells, thereby influencing tissue morphogenesis. Cell repulsion requires bidirectional trans-endocytosis of clustered Eph-ephrin complexes at cell interfaces, but the mechanisms underlying this process are poorly understood. Here, we identified an actin-regulating pathway allowing ephrinB(+) cells to trans-endocytose EphB receptors from opposing cells. Live imaging revealed Rac-dependent F-actin enrichment at sites of EphB2 internalization, but not during vesicle trafficking...
September 12, 2016: Journal of Cell Biology
https://www.readbyqxmd.com/read/27574806/kinase-gene-expression-profiling-of-metastatic-clear-cell-renal-cell-carcinoma-tissue-identifies-potential-new-therapeutic-targets
#15
Pooja Ghatalia, Eddy S Yang, Brittany N Lasseigne, Ryne C Ramaker, Sara J Cooper, Dongquan Chen, Sunil Sudarshan, Shi Wei, Arjun S Guru, Amy Zhao, Tiffiny Cooper, Deborah L Della Manna, Gurudatta Naik, Richard M Myers, Guru Sonpavde
Kinases are therapeutically actionable targets. Kinase inhibitors targeting vascular endothelial growth factor receptors (VEGFR) and mammalian target of rapamycin (mTOR) improve outcomes in metastatic clear cell renal cell carcinoma (ccRCC), but are not curative. Metastatic tumor tissue has not been comprehensively studied for kinase gene expression. Paired intra-patient kinase gene expression analysis in primary tumor (T), matched normal kidney (N) and metastatic tumor tissue (M) may assist in identifying drivers of metastasis and prioritizing therapeutic targets...
2016: PloS One
https://www.readbyqxmd.com/read/27504909/enhancer-decommissioning-by-snail1-induced-competitive-displacement-of-tcf7l2-and-down-regulation-of-transcriptional-activators-results-in-ephb2-silencing
#16
Oskar Schnappauf, Sven Beyes, Annika Dertmann, Vivien Freihen, Patrick Frey, Sabine Jägle, Katja Rose, Tom Michoel, Rudolf Grosschedl, Andreas Hecht
Transcriptional silencing is a major cause for the inactivation of tumor suppressor genes, however, the underlying mechanisms are only poorly understood. The EPHB2 gene encodes a receptor tyrosine kinase that controls epithelial cell migration and allocation in intestinal crypts. Through its ability to restrict cell spreading, EPHB2 functions as a tumor suppressor in colorectal cancer whose expression is frequently lost as tumors progress to the carcinoma stage. Previously we reported that EPHB2 expression depends on a transcriptional enhancer whose activity is diminished in EPHB2 non-expressing cells...
November 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27494882/simultaneous-targeting-of-eph-receptors-in-glioblastoma
#17
Sara Ferluga, Carla Maria Lema Tomé, Denise Mazess Herpai, Ralph D'Agostino, Waldemar Debinski
Eph tyrosine kinase receptors are frequently overexpressed and functional in many cancers, and they are attractive candidates for targeted therapy. Here, we analyzed the expression of Eph receptor A3, one of the most up-regulated factors in glioblastoma cells cultured under tumorsphere-forming conditions, together with EphA2 and EphB2 receptors. EphA3 was overexpressed in up to 60% of glioblastoma tumors tested, but not in normal brain. EphA3 was localized in scattered areas of the tumor, the invasive ring, and niches near tumor vessels...
September 13, 2016: Oncotarget
https://www.readbyqxmd.com/read/27476799/novel-genetic-variants-associated-with-increased-vertebral-volumetric-bmd-reduced-vertebral-fracture-risk-and-increased-expression-of-slc1a3-and-ephb2
#18
Carrie M Nielson, Ching-Ti Liu, Albert V Smith, Cheryl L Ackert-Bicknell, Sjur Reppe, Johanna Jakobsdottir, Christina Wassel, Thomas C Register, Ling Oei, Nerea Alonso, Edwin H Oei, Neeta Parimi, Elizabeth J Samelson, Mike A Nalls, Joseph Zmuda, Thomas Lang, Mary Bouxsein, Jeanne Latourelle, Melina Claussnitzer, Kristin Siggeirsdottir, Priya Srikanth, Erik Lorentzen, Liesbeth Vandenput, Carl Langefeld, Laura Raffield, Greg Terry, Amanda J Cox, Matthew A Allison, Michael H Criqui, Don Bowden, M Arfan Ikram, Dan Mellström, Magnus K Karlsson, John Carr, Matthew Budoff, Caroline Phillips, L Adrienne Cupples, Wen-Chi Chou, Richard H Myers, Stuart H Ralston, Kaare M Gautvik, Peggy M Cawthon, Steven Cummings, David Karasik, Fernando Rivadeneira, Vilmundur Gudnason, Eric S Orwoll, Tamara B Harris, Claes Ohlsson, Douglas P Kiel, Yi-Hsiang Hsu
Genome-wide association studies (GWASs) have revealed numerous loci for areal bone mineral density (aBMD). We completed the first GWAS meta-analysis (n = 15,275) of lumbar spine volumetric BMD (vBMD) measured by quantitative computed tomography (QCT), allowing for examination of the trabecular bone compartment. SNPs that were significantly associated with vBMD were also examined in two GWAS meta-analyses to determine associations with morphometric vertebral fracture (n = 21,701) and clinical vertebral fracture (n = 5893)...
December 2016: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/27446912/gene-expression-profiling-of-muscle-stem-cells-identifies-novel-regulators-of-postnatal-myogenesis
#19
Sonia Alonso-Martin, Anne Rochat, Despoina Mademtzoglou, Jessica Morais, Aurélien de Reyniès, Frédéric Auradé, Ted Hung-Tse Chang, Peter S Zammit, Frédéric Relaix
Skeletal muscle growth and regeneration require a population of muscle stem cells, the satellite cells, located in close contact to the myofiber. These cells are specified during fetal and early postnatal development in mice from a Pax3/7 population of embryonic progenitor cells. As little is known about the genetic control of their formation and maintenance, we performed a genome-wide chronological expression profile identifying the dynamic transcriptomic changes involved in establishment of muscle stem cells through life, and acquisition of muscle stem cell properties...
2016: Frontiers in Cell and Developmental Biology
https://www.readbyqxmd.com/read/27419051/identification-of-approved-drugs-that-inhibit-the-binding-of-amyloid-%C3%AE-oligomers-to-ephrin-type-b-receptor-2
#20
Koichiro Suzuki, Takahiro Aimi, Tomoaki Ishihara, Tohru Mizushima
Ephrin type-B receptor 2 (EphB2) is a member of the receptor tyrosine kinase family and plays an important role in learning and memory functions. In patients with Alzheimer's disease (AD) and in mouse models of AD, a reduction in the hippocampal EphB2 level is observed. It was recently reported that normalization of the EphB2 level in the dentate gyrus rescues memory function in a mouse model of AD, suggesting that drugs that restore EphB2 levels may be beneficial in the treatment of AD. Amyloid β (Aβ) oligomers, which are believed to be key molecules involved in the pathogenesis of AD, induce EphB2 degradation through their direct binding to EphB2...
May 2016: FEBS Open Bio
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