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PAD AND blood pressure

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https://www.readbyqxmd.com/read/29786411/bad-transmission-and-sad-distribution-a-new-scenario-for-critical-limb-ischemia
#1
Roberto Ferraresi, Giovanni Mauri, Fabrizio Losurdo, Nicola Troisi, Diego Brancaccio, Carlo M Caravaggi, Luca Neri
BACKGROUND: Most of the studies on peripheral artery disease (PAD) focused on above-the-ankle artery disease, while less is known about foot artery disease. We hypothesize a scenario were two different diseases can be present in PAD patients, big artery disease (BAD) and small artery disease (SAD), overlapping at the foot level; the aim of this study is to evaluate their prevalence and their correlation with risk factors and critical limb ischemia (CLI) in a large cohort of patients with symptomatic PAD...
May 22, 2018: Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/29783062/ykl-40-levels-increase-with-declining-ankle-brachial-index-and-are-associated-with-long-term-cardiovascular-mortality-in-peripheral-arterial-disease-patients
#2
Clemens Höbaus, Maximilian Tscharre, Carsten Thilo Herz, Gerfried Pesau, Thomas Wrba, Renate Koppensteiner, Gerit-Holger Schernthaner
BACKGROUND AND AIMS: YKL-40 is an inflammatory marker secreted by macrophages and is expressed in atherosclerotic plaques. YKL-40 increases in coronary artery disease (CAD) with poor coronary collateral vessel development. Higher levels are linked to reduced survival in CAD patients. Studies evaluating YKL-40 in patients with peripheral arterial disease (PAD) are scarce. This study aims to elucidate a possible link between YKL-40 and PAD severity as well as cardiovascular long-term mortality...
May 9, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29776647/-effect-of-green-alga-ulva-lactuca-polysaccharides-supplementation-on-blood-pressure-and-on-atherogenic-risk-factors-in-rats-fed-a-high-fat-diet
#3
Z I Tair, F Bensalah, F Boukortt
AIM OF THE STUDY: To highlight the benefits of green alga Ulva lactuca polysaccharides supplementation on blood pressure and atherogenic risk factors in rats fed a high fat diet. METHODS: Wistar male rats were fed a high fat diet (30% sheep fat) for 3 months. At an average body weight (BW) of 360g, the rats (n=18) were divided into 3 groups and consumed, for 28 days, either a high fat diet (HFD) or a high fat diet enriched with 1% of whole green algae (WGA) powder or with 1% of its polysaccharides (PLS)...
May 15, 2018: Annales de Cardiologie et D'angéiologie
https://www.readbyqxmd.com/read/29658630/lumbar-sympathectomy-versus-prostanoids-for-critical-limb-ischaemia-due-to-non-reconstructable-peripheral-arterial-disease
#4
REVIEW
Indrani Sen, Sunil Agarwal, Prathap Tharyan, Rachel Forster
BACKGROUND: Peripheral arterial disease (PAD) is a common circulatory problem that can lead to reduced blood flow to the limbs, which may result in critical limb ischaemia (CLI), a painful manifestation that occurs when a person is at rest. The mainstay of treatment for CLI is surgical or endovascular repair. However, when these means of treatment are not suitable, due to anatomical reasons or comorbidities, treatment for pain is limited. Lumbar sympathectomy and prostanoids have both been shown to reduce pain from CLI in people who suffer from non-reconstructable PAD, but there is currently insufficient evidence to determine if one treatment is superior...
April 16, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29655790/hdac11-deletion-reduces-fructose-induced-cardiac-dyslipidemia-apoptosis-and-inflammation-by-attenuating-oxidative-stress-injury
#5
Xiao-Di Fan, Lan-Lan Wan, Man Duan, Shan Lu
Diabetes mellitus (DM) is a risk factor for abnormal heart development, but the molecular mechanism remains obscure. Histone deacetylase 11 (HDAC11), the most recently identified histone deacetylase, is the sole member of class IV HDACs. However, its role in diabetic cardiac injury is still poorly understood. In the present study, we attempted to explore the effects of HDAC11 on fructose (Fru)-induced cardiac injury using the wild type (HDAC11+/+ ) and knockout (HDAC11-/- ) mice. The results indicated that HDAC11 was significantly expressed in human and mouse diabetic heart failure (DHF) hearts...
April 12, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29648515/peripheral-revascularization-attenuates-the-exercise-pressor-reflex-and-increases-coronary-exercise-hyperemia-in-peripheral-arterial-disease
#6
Amanda J Miller, J Carter Luck, Danielle Jin-Kwang Kim, Urs A Leuenberger, Faisal Aziz, John F Radtka, Lawrence I Sinoway, Matthew D Muller
Peripheral arterial disease (PAD) is associated with augmented blood pressure (BP) and impaired coronary blood flow responses to exercise, which may increase cardiovascular risk. We investigated the effects of leg revascularization on the BP and coronary blood flow responses to exercise in PAD. Seventeen PAD patients (11 men, 66 {plus minus} 2 yr) performed single-leg plantar flexion exercise 24 hr before and one month following leg revascularization. BP and heart rate (HR) were measured continuously and rate pressure product (systolic BP x HR) was calculated as an index of myocardial oxygen demand...
April 12, 2018: Journal of Applied Physiology
https://www.readbyqxmd.com/read/29620609/the-use-of-closed-incision-negative-pressure-wound-therapy-in-orthopaedic-surgery
#7
Denis Nam, Robert A Sershon, Brett R Levine, Craig J Della Valle
Wound complications and surgical site infections after orthopaedic procedures result in substantial morbidity and costs. Traditional postoperative wound care consists of applying sterile, dry gauze and abdominal pads to the surgical site, with more frequent dressing changes performed in cases in which wound drainage is excessive. Persistent incisional drainage is of particular concern because it increases the risk of deep infection. The use of closed incision negative-pressure wound therapy (ciNPWT) to manage delayed wound healing was first reported a decade ago, and the benefits of this treatment modality include wound contraction with diminished tensile forces, stabilization of the wound environment, decreased edema and improved removal of exudate, and increased blood and lymphatic flow...
May 1, 2018: Journal of the American Academy of Orthopaedic Surgeons
https://www.readbyqxmd.com/read/29618157/angiopoietin-2-and-survival-in-peripheral-artery-disease-patients
#8
Clemens Höbaus, Gerfried Pesau, Carsten Thilo Herz, Thomas Wrba, Renate Koppensteiner, Gerit-Holger Schernthaner
Survival of peripheral arterial disease (PAD) patients increased over the last decade due to increased use of secondary preventive medication and rapid revascularization of PAD patients. Angiogenetic markers such as vascular endothelial growth factor (VEGF), angiopoietin-2 (Ang-2) and its receptor Tie-2 might be useful markers to assess the residual risk for mortality in PAD patients. The aim of this study was to evaluate angiogenetic markers for the prediction of mortality in a PAD cohort. For this purpose, 366 patients (mean age: 69 ± 10 years) with PAD Fontaine stage I or II were included and followed up over a 5-year study period...
April 2018: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29611173/the-relationship-between-pulse-waveform-analysis-indices-endothelial-function-and-clinical-outcomes-in-patients-with-peripheral-artery-disease-treated-using-percutaneous-transluminal-angioplasty-during-a-one-year-follow-up-period
#9
Paweł S Kaczmarczyk, Paweł Maga, Rafał Niżankowski, Rafał Januszek, Marzena Frołow, Mikołaj Maga, Jolanta Kościelniak, Andrzej Belowski
BACKGROUND: The aim of the current study was to assess the relationship between potential predictors of clinical outcomes after percutaneous transluminal angioplasty (PTA) of peripheral arteries during a one-year follow-up. Indices of endothelial function (EF), arterial pulse waveform analysis (aPWA) and markers of peripheral arteries ischemia were among those mostly examined. METHODS: The study comprised of 72 individuals with PAD who underwent PTA of the peripheral arteries...
April 3, 2018: Cardiology Journal
https://www.readbyqxmd.com/read/29591369/pharmacists-impact-on-secondary-stroke-prevention
#10
Jennifer Andres, Olivia Stanton-Ameisen, Sara Walton, Charles Ruchalski
BACKGROUND: Patients admitted to our institution with a cerebrovascular accident (stroke) or transient ischemic attack (TIA) are referred to the pharmacist-run stroke prevention clinic (SPC) for medication and risk factor management. OBJECTIVE: The objective was to determine if patients receiving care from the SPC have better outcomes than patients who received usual care. METHODS: This was a retrospective chart review of patients referred to the SPC...
January 1, 2018: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/29570598/effects-of-resistance-training-on-cardiovascular-function-in-patients-with-peripheral-artery-disease-a-randomized-controlled-trial
#11
Ana P F Gomes, Marilia A Correia, Antônio H G Soares, Gabriel G Cucato, Aluísio H R A Lima, Bruno R Cavalcante, Dário C Sobral-Filho, Raphael M Ritti-Dias
Gomes, APF, Correia, MA, Soares, AHG, Cucato, GG, Lima, AHRA, Cavalcante, BR, Sobral-Filho, DC, and Ritti-Dias, RM. Effects of resistance training on cardiovascular function in patients with peripheral artery disease: A randomized controlled trial. J Strength Cond Res 32(4): 1072-1080, 2018-The aim of this study was to analyze the effects of resistance training on cardiovascular function of patients with peripheral artery disease (PAD). In total, 30 patients with PAD were invited to participate in this randomized controlled trial, randomly allocated to a control (n = 15, 66 ± 2 years; stretching and relaxation exercises) or resistance training group (n = 15, 60 ± 3 years; 3 sets of 10 repetitions of 8 whole-body exercises, with a 2-minute interval between sets)...
April 2018: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29551091/evaluation-of-skeletal-muscle-microvascular-perfusion-of-lower-extremities-by-cardiovascular-magnetic-resonance-arterial-spin-labeling-blood-oxygenation-level-dependent-and-intravoxel-incoherent-motion-techniques
#12
Shiteng Suo, Lan Zhang, Hui Tang, Qihong Ni, Suqin Li, Haimin Mao, Xiangyu Liu, Shengyun He, Jianxun Qu, Qing Lu, Jianrong Xu
BACKGROUND: Noninvasive cardiovascular magnetic resonance (CMR) techniques including arterial spin labeling (ASL), blood oxygenation level-dependent (BOLD), and intravoxel incoherent motion (IVIM), are capable of measuring tissue perfusion-related parameters. We sought to evaluate and compare these three CMR techniques in characterizing skeletal muscle perfusion in lower extremities and to investigate their abilities to diagnose and assess the severity of peripheral arterial disease (PAD)...
March 19, 2018: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/29522355/eight-weeks-of-nitrate-supplementation-improves-blood-flow-and-reduces-the-exaggerated-pressor-response-during-forearm-exercise-in-peripheral-arterial-disease
#13
Nicholas T Kruse, Kenichi Ueda, William E Hughes, Darren P Casey
Peripheral arterial disease (PAD) is characterized by a reduced blood flow (BF) and elevated blood pressure (pressor) response during lower extremity exercise. Although PAD is evident in the upper extremities no studies have determined BF and pressor responses during upper extremity exercise in PAD. Emerging evidence suggests that inorganic nitrate (NO3 ) supplementation may serve as an alternative dietary strategy to boost nitric oxide bioavailability, improving exercising BF and pressor responses during exercise...
March 9, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29519276/-effects-of-acute-respiratory-distress-syndrome-induced-by-endotoxin-on-the-right-ventricular-function-in-rats
#14
Shaolei Ma, Yujie Wang, Xiangrong Zuo, Jing Yao, Quan Cao
OBJECTIVE: To explore the effect of acute respiratory distress syndrome (ARDS) induced by endotoxin on the right ventricular function in rats. METHODS: Sixty male Sprague-Dawley (SD) rats were randomly divided into normal saline (NS) control group and lipopolysaccharide (LPS) model group with 30 rats in each group. The rat model of ARDS was reproduced by intratracheal instillation of LPS 10 mg/kg after tracheotomy, and the rats in NS control group was intratracheally given the same volume of NS instead of LPS...
March 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/29516595/the-effects-of-a-heating-pad-on-anxiety-pain-and-distress-during-urodynamic-study-in-the-female-patients-with-stress-urinary-incontinence
#15
Jong Wook Kim, Hyun Ju Kim, Young Joo Park, Sung G Kang, Jae Y Park, Jae Hyun Bae, Seok Ho Kang, Hong Seok Park, Du Geon Moon, Jun Cheon, Jeong Gu Lee, Je Jong Kim, Mi Mi Oh
AIMS: Although generally well tolerated, a urodynamic study is an unpleasant and stressful procedure for some patients. This study evaluated the effects of a heating pad on anxiety, pain, and distress during urodynamic studies in female patients with stress urinary incontinence. METHODS: A total of 74 female patients with stress urinary incontinence who underwent a urodynamic study between May 2015 and October 2015 were randomized to either the experimental group using a heating pad (n = 37) or control group (n = 37)...
March 2018: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29459079/anti-hypertensive-treatment-in-peripheral-artery-disease
#16
REVIEW
Costas Tsioufis, Ioannis Andrikou, Gerasimos Siasos, Konstantinos Filis, Dimitrios Tousoulis
Peripheral artery disease (PAD) affects more than 200 million people worldwide. Hypertension has been related to increased risk of PAD. The treatment of elevated blood pressure (BP) in these patients is indicated to lower the cardiovascular risk with a BP goal of less than 130/80mmHg. Although there is no evidence that one class of antihypertensive medication or strategy is superior for BP lowering in PAD, the use of renin-angiotensin-system (RAS) inhibitors can be effective to reduce the cardiovascular risk...
February 16, 2018: Current Opinion in Pharmacology
https://www.readbyqxmd.com/read/29456512/local-injections-of-superoxide-dismutase-attenuate-the-exercise-pressor-reflex-in-rats-with-femoral-artery-occlusion
#17
Jihong Xing, Jian Lu, Jiahao Liu, Jianhua Li
The exercise pressor reflex is amplified in patients with peripheral artery disease (PAD) and in an experimental PAD model of rats induced by femoral artery occlusion. Heightened blood pressure worsens the restricted blood flow directed to the limbs in this disease. The purpose of this study was to determine the role played by muscle oxidative stress in regulating the augmented pressor response to static exercise in PAD. We hypothesized that limb ischemia impairs muscle superoxide dismutase (SOD) thereby leading to abnormal autonomic responsiveness observed in PAD animals, and a chronic compensation of SOD for anti-oxidation improves the exaggerated exercise pressor reflex...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29346374/epidemiological-investigation-into-the-prevalence-of-abnormal-inter-arm-blood-pressure-differences-among-different-ethnicities-in-xinjiang-china
#18
Ling Sun, Ting Zou, Bao-Zhu Wang, Fen Liu, Qing-Hua Yuan, Yi-Tong Ma, Xiang Ma
OBJECTIVES: The prevalence of and risk factors for IAD among different ethnicity groups was unknown. Our aim was to investigate the prevalence of and risk factors for IAD among Han, Uygur and Kazakh ethnicities in Xinjiang. China. METHODS: In total, 14,618 adult participants (7,799 males and 6,819 females) were recruited from the Cardiovascular Risk Survey. A 4-stage stratified cluster random sampling method was used. The participants' personal information and medical history were assessed by questionnaire...
2018: PloS One
https://www.readbyqxmd.com/read/29260031/effect-of-blood-pressure-variability-on-early-neurological-deterioration-in-single-small-subcortical-infarction-with-parental-arterial-disease
#19
Zuowei Duan, Lihong Tao, Tieyu Tang, Changbiao Fu, Jiangbing Liu, Bin Chen, Zhensheng Liu, Haifeng Zhang, Yihui Liu, Xinjiang Zhang
Background and purpose: Early neurological deterioration (END) is not uncommon in acute single small subcortical infarct (SSSI), especially in those with parental arterial disease (PAD). The purpose of this study was to elucidate the effect of BP variability on the development of END as well as functional outcome at 90 days in SSSI and to determine whether the effect is linked to the status of parent artery. Methods: Consecutive patients with acute SSSI were prospectively recruited from the First People's Hospital of Yangzhou between Aug 2013 and Jul 2016...
September 2017: ENeurologicalSci
https://www.readbyqxmd.com/read/29236794/qualitative-analysis-of-the-viability-of-autogenous-fat-grafts-grafted-in-different-environments-of-interstitial-pressure-preliminary-results-and-description-of-a-new-experimental-model-in-mini-pigs
#20
Eduardo Gustavo Pires de Arruda, Alexandre Mendonça Munhoz, Walter Matsumoto, Thiago Ueda, Renata de Almeida Coudry, Rolf Gemperli
PURPOSE: To evaluate the feasibility of an experimental model of autologous fat graft (AFG) in different interstitial pressure (IP) environments. METHODS: Three mini-pigs(Minipig-BR) with age of 8 months (weight: 25-30 kg) were used. AFG were collected from the bucal fat pad, and grafted in the intramuscular pocket (biceps femoralis muscle). IP model was based on a fusiform ressection followed by primary closure "under tension". A blood pressure catheter located in the intramuscular region connected to a pressure module was applied to quantify IP...
November 2017: Acta Cirúrgica Brasileira
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