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PAD AND blood pressure

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https://www.readbyqxmd.com/read/28219672/changes-in-cardiovascular-function-based-on-adrenalin-and-norepinephrine-metabolism-in-ovariectomized-rats
#1
Hai Jiang, Wenpei Bai, Wenjuan Wang, Jing Zhang, Ke Wang, Yao Liu, Shuya Liu, Jing Jia, Lihua Qin
Menopause is a cardiovascular risk factor in women, and cardiovascular changes during perimenopause can increase the risk. We observed the influence of plasma adrenalin and norepinephrine and their metabolites on the cardiovascular system and the rectification effect of estrogen in ovariectomized rats. Fifty-four adult female Sprague-Dawley rats were randomly divided into sham (Sham), ovariectomized (OVX), or ovariectomized+estrogen treatment groups (OVX+E), with 18 rats in each. The Sham and OVX groups were given normal saline and the OVX+E group was given estradiol valerate beginning 2weeks after ovariectomy and continuing for 4weeks...
February 17, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28202852/association-of-serum-uric-acid-levels-with-leg-ischemia-in-patients-with-peripheral-arterial-disease-after-treatment
#2
Yoko Sotoda, Shigeki Hirooka, Hiroyuki Orita, Ichiro Wakabayashi
AIM: We investigated the relationships of serum uric acid levels with the progression of atherosclerosis in patients with peripheral arterial disease (PAD) after treatment. METHODS: Subjects were male patients diagnosed with PAD. Atherosclerosis at the common carotid artery was evaluated based on its intima-media thickness (IMT). Leg arterial flow was evaluated by measuring ankle-brachial index (ABI) and exercise-induced decrease in ABI. RESULTS: Among various risk factors including age, blood pressure, adiposity, estimated glomerular filtration rate, and blood lipid, blood glucose, uric acid, fibrinogen and C-reactive protein levels, only uric acid levels showed significant correlations with ABI [Pearson's correlation coefficient, -0...
February 15, 2017: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/28197286/pulse-pressure-and-upstroke-time-are-useful-parameters-for-the-diagnosis-of-peripheral-artery-disease-in-patients-with-normal-ankle-brachial-index
#3
Shunsuke Kiuchi, Shinji Hisatake, Ippei Watanabe, Mikihito Toda, Takayuki Kabuki, Takashi Oka, Shintaro Dobashi, Takanori Ikeda
BACKGROUND: Some peripheral artery disease (PAD) patients have normal ankle brachial index (ABI) (0.9 - 1.4), although ABI is a useful parameter for the diagnosis of PAD. We investigated whether other parameters of ABI report sheet are useful to detect these patients. METHODS: We initially enrolled 3,912 patients (7,824 limbs) who underwent ABI for the first time. Subjects who have normal ABI were divided into the PAD group (n = 136) and the non-PAD group (n = 240) by lower extremity ultrasonography...
October 2016: Cardiology Research
https://www.readbyqxmd.com/read/28179001/caryocar-brasiliense-oil-improves-cardiac-function-by-increasing-serca2a-plb-ratio-despite-no-significant-changes-in-cardiovascular-risk-factors-in-rats
#4
Lidiane Guedes Oliveira, Lauane Gomes Moreno, Dirceu Sousa Melo, Liliane Vanessa Costa-Pereira, Mayara Medeiros de Freitas Carvalho, Paulo Henrique Evangelista Silva, Ana Maria Alves, Flávio de Castro Magalhães, Marco Fabrício Dias-Peixoto, Elizabethe Adriana Esteves
BACKGROUND: Caryocar brasiliense (pequi) oil is high in monounsaturated fat acids (MUFA), especially oleic, and in carotenoids, which have been associated with protection against cardiovascular disease. However, this food is poorly studied in this context, especially in the cardiac function. Therefore, we investigated the effects of a long-term intake of pequi oil in systemic cardiovascular risk factors and in the ex vivo cardiac function of rats. METHODS: Previously, we determined fatty acids and carotenoids in pequi oil...
February 8, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28168512/automated-oscillometric-blood-pressure-and-pulse-wave-acquisition-for-evaluation-of-vascular-stiffness-in-atherosclerosis
#5
Alexander Massmann, Jennifer Stemler, Peter Fries, Reinhard Kubale, Lutz Erwin Kraushaar, Arno Buecker
OBJECTIVE: Evaluation of diagnostic accuracy of an oscillometry-based device (VascAssist) combining fully automated ankle-brachial index (ABI) and pulse-wave velocity (PWV) assessment for detection of peripheral arterial disease (PAD). SUBJECTS AND METHODS: 110 consecutive subjects including symptomatic PAD patients (n = 41) and healthy PAD-free participants (n = 69) were recruited. All subjects underwent standard manual Doppler-based ABI (sABI) and oscillometry-based automated ABI (aABI) measurements (VascAssist)...
February 6, 2017: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/28150285/cross-sectional-study-of-the-ankle-brachial-index-and-cardiovascular-risk-factors-in-postmenopausal-women
#6
Paweł Wierzchowski, Tadeusz Dereziński, Arkadiusz Migdalski, Łukasz Woda, Beata Wąsikowska, Grzegorz Jakubowski, Arkadiusz Jawień
BACKGROUND: The incidence of peripheral artery disease (PAD) and cardiovascular events in the female population has been on the increase. A: IM: To analyze the risk factors of a cardiovascular event and PAD in women and to assess the usefulness of the ankle-brachial index (ABI). METHODS: Evaluation of selected parameters in a cohort of 365 women living in the same district. The following data were prospectively recorded: weight, height, waist size, hip circumference, smoking, the Intima Media Complex (IMC), ABI value and laboratory results...
February 2, 2017: Kardiologia Polska
https://www.readbyqxmd.com/read/28099586/serotoninergic-modulation-of-basal-cardiovascular-responses-and-responses-induced-by-isotonic-extracellular-volume-expansion-in-rats
#7
Isadora Ferraz Semionatto, Adrieli Oliveira Raminelli, Angelica Cristina Alves, Caroline Santos Capitelli, Rosangela Soares Chriguer
Background: Isotonic blood volume expansion (BVE) induced alterations of sympathetic and parasympathetic activity in the heart and blood vessels, which can be modulated by serotonergic pathways. Objective: To evaluate the effect of saline or serotonergic agonist (DOI) administration in the hypothalamic paraventricular nucleus (PVN) on cardiovascular responses after BVE. Methods: We recorded pulsatile blood pressure through the femoral artery to obtain the mean arterial pressure (MAP), systolic (SBP) and diastolic blood pressure (DBP), heart rate (HR) and the sympathetic-vagal ratio (LF/HF) of Wistar rats before and after they received bilateral microinjections of saline or DOI into the PVN, followed by BVE...
January 16, 2017: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/28012910/a-single-bout-of-arm-crank-exercise-promotes-positive-emotions-and-post-exercise-hypotension-in-patients-with-symptomatic-peripheral-artery%C3%A2-disease
#8
B R Cavalcante, R M Ritti-Dias, A H G Soares, A H Lima, M A Correia, L D De Matos, F Gobbi, A S Leicht, N Wolosker, G G Cucato
OBJECTIVE/BACKGROUND: The objective was to analyze the acute effects of a single bout of arm cranking exercise on affective and cardiovascular parameters in patients with symptomatic peripheral artery disease (PAD). METHODS: This was a prospective, controlled, crossover study. Eleven men with symptomatic PAD underwent two experimental sessions in a random order: control or arm crank exercise (15 × 2 minutes bouts of arm crank exercise interrupted by 2 minutes rest intervals)...
December 21, 2016: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/28003211/lower-limb-hot-water-immersion-acutely-induces-beneficial-hemodynamic-and-cardiovascular-responses-in-peripheral-arterial-disease-and-healthy-elderly-controls
#9
Kate N Thomas, Andre Marie van Rij, Samuel J E Lucas, James D Cotter
Passive heat induces beneficial perfusion profiles, provides substantive cardiovascular strain and reduces blood pressure, thereby holding potential for healthy and cardiovascular disease populations. The aim of this study was to assess acute responses to passive heat via lower-limb hot-water immersion in patients with peripheral arterial disease (PAD) and healthy, elderly controls. Eleven patients with PAD (age 71±6 y, 7 male) and ten Controls (age 72±7 y, 8 male) underwent hot-water immersion (30 min waist-level immersion in 42...
December 21, 2016: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/27894602/evolution-and-degree-of-control-of-cardiovascular-risk-factors-after-5-years-of-follow-up-and-their-relationship-with-the-incidence-of-peripheral-arterial-disease-artper-cohort
#10
Rosa Forés, María Teresa Alzamora, Guillem Pera, Marta Valverde, Maria Angla, José Miguel Baena-Díez, Xavier Mundet-Tuduri
BACKGROUND AND OBJECTIVE: Although cardiovascular risk factors (CVRF) are well known, their degree of control is not optimal. The aim of this study is to assess the evolution and control of CVRFs after 5 years of monitoring a population-based cohort and their association with the incidence of peripheral arterial disease (PAD). MATERIAL AND METHOD: Prospective cohort study recruited between 2006-2008. Second phase between 2011-2012. An ankle brachial index was determined for all participants in both phases...
February 9, 2017: Medicina Clínica
https://www.readbyqxmd.com/read/27873008/arterial-stiffness-and-peripheral-arterial-disease-in-patients-with-systemic-lupus-erythematosus
#11
Konstantinos Tziomalos, Ioannis Gkougkourelas, Alexandros Sarantopoulos, Eleni Bekiari, Evangelia Makri, Nikolaos Raptis, Konstantinos Tselios, Marianna Pantoura, Apostolos I Hatzitolios, Panagiota Boura
Systemic lupus erythematosus (SLE) is associated with increased cardiovascular risk. We aimed to evaluate arterial stiffness and the ankle brachial index (ABI), two markers of subclinical cardiovascular disease, in SLE. We studied 55 patients with SLE (12.7% males, age 53.3 ± 15.3 years) and 61 age- and gender-matched controls. Arterial stiffness was evaluated by measuring pulse wave velocity (PWV), augmentation index (AIx) and central systolic, diastolic, pulse and mean blood pressure (BP). Peripheral arterial disease was defined as ABI ≤ 0...
February 2017: Rheumatology International
https://www.readbyqxmd.com/read/27830155/high-systolic-and-diastolic-blood-pressure-variability-is-correlated-with-the-occurrence-of-peripheral-arterial-disease-in-the-first-decade-following-a-diagnosis-of-type-2-diabetes-mellitus-a-new-biomarker-from-old-measurement
#12
Chi-Hsiao Yeh, Hsiu-Chin Yu, Tzu-Yen Huang, Pin-Fu Huang, Yao-Chang Wang, Tzu-Ping Chen, Shun-Ying Yin
Background. To assess whether the visit-to-visit variability in blood pressure (BP) is a risk factor of peripheral arterial disease (PAD) in patients with type 2 diabetes mellitus (T2DM) 10 years after diagnosis. Methods. The electronic medical records of 825 patients, who were diagnosed with type 2 diabetes mellitus (T2DM) during 2000-2002 and regularly followed for 10 years, were retrospectively reviewed. A total of 53,284 clinic visit records, including analysis of BP, BMI, serum glycohemoglobin, and lipid profile, were analyzed...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27805541/inulin-oligofructose-attenuates-metabolic-syndrome-in-high-carbohydrate-high-fat-diet-fed-rats
#13
Senthil A Kumar, Leigh C Ward, Lindsay Brown
Prebiotics alter bacterial content in the colon, and therefore could be useful for obesity management. We investigated the changes following addition of inulin oligofructose (IO) in the food of rats fed either a corn starch (C) diet or a high-carbohydrate, high-fat (H) diet as a model of diet-induced metabolic syndrome. IO did not affect food intake, but reduced body weight gain by 5·3 and 12·3 % in corn starch+inulin oligofructose (CIO) and high-carbohydrate, high-fat with inulin oligofructose (HIO) rats, respectively...
November 2016: British Journal of Nutrition
https://www.readbyqxmd.com/read/27760183/a-novel-index-using-ankle-hemodynamic-parameters-to-assess-the-severity-of-peripheral-arterial-disease-a-pilot-study
#14
Jun Tanno, Yodo Gatate, Takatoshi Kasai, Shintaro Nakano, Takaaki Senbonmatsu, Osamu Sato, Shigeru Ichioka, Makoto Kuro-O, Shigeyuki Nishimura
In peripheral arterial disease (PAD) of the lower extremities, the presence of flow-limiting stenoses can be objectively detected by the ankle-brachial index (ABI). However, the severity of ischemic symptoms is not necessarily associated with the ABI value. Atherosclerotic plaque in lower extremity PAD induces ankle arterial stiffness and reduces ankle vascular resistance, which may decrease ankle blood flow and cause ischemic symptoms. We hypothesized that the ankle hemodynamic index (AHI), defined as the ratio of ankle arterial stiffness to ankle vascular resistance, could be used to assess the blood supply deficiency in a diseased lower limb in patients with PAD...
2016: PloS One
https://www.readbyqxmd.com/read/27693032/an-endovascular-model-of-ischemic-myopathy-from-peripheral-arterial-disease
#15
Chandler A Long, Lucas H Timmins, Panagiotis Koutakis, Traci T Goodchild, David J Lefer, Iraklis I Pipinos, George P Casale, Luke P Brewster
OBJECTIVE: Peripheral arterial disease (PAD) is a significant age-related medical condition with limited pharmacologic options. Severe PAD, termed critical limb ischemia, can lead to amputation. Skeletal muscle is the end organ most affected by PAD, leading to ischemic myopathy and debility of the patient. Currently, there are not any therapeutics to treat ischemic myopathy, and proposed biologic agents have not been optimized owing to a lack of preclinical models of PAD. Because a large animal model of ischemic myopathy may be useful in defining the optimal dosing and delivery regimens, the objective was to create and to characterize a swine model of ischemic myopathy that mimics patients with severe PAD...
September 29, 2016: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/27689831/noninvasive-physiologic-vascular-studies-a-guide-to-diagnosing-peripheral-arterial-disease
#16
Robert C Sibley, Stephen P Reis, Jarrod J MacFarlane, Mark A Reddick, Sanjeeva P Kalva, Patrick D Sutphin
Noninvasive physiologic vascular studies play an important role in the diagnosis and characterization in peripheral arterial disease (PAD) of the lower extremity. These studies evaluate the physiologic parameters of blood flow through segmental arterial pressures, Doppler waveforms, and pulse volume recordings. Collectively, they comprise a powerful toolset for defining the functionality of the arterial system, localizing the site of disease, and providing prognostic data. This technology has been widely adopted by diverse medical specialty practitioners, including radiologists, surgeons, cardiologists, and primary care providers...
January 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/27689032/association-between-vitamin-d-status-and-risk-of-peripheral-arterial-disease-the-dong-gu-study
#17
Su-Hyun Oh, Sun-Seog Kweon, Jin-Su Choi, Jung-Ae Rhee, Young-Hoon Lee, Hae-Sung Nam, Seul-Ki Jeong, Kyeong-Soo Park, So-Yeon Ryu, Seong-Woo Choi, Min-Ho Shin
Low levels of vitamin D have been associated with increased cardiovascular disease risk. However, few studies have evaluated the association between vitamin D status and peripheral arterial disease (PAD). We therefore aimed to investigate whether low 25-hydroxyvitamin D (25(OH)D) levels were associated with increased risk of PAD in the Korean population. This cross-sectional study was conducted among 8,960 subjects aged 50 years or older without known myocardial infarction or stroke. PAD was defined by an ankle brachial blood pressure index <0...
September 2016: Chonnam Medical Journal
https://www.readbyqxmd.com/read/27651612/role-of-tranexamic-acid-in-reducing-blood-loss-in-vaginal-delivery
#18
Priyankur Roy, M S Sujatha, Ambarisha Bhandiwad, Bivas Biswas
INTRODUCTION: Anti-fibrinolytic agents are used to reduce obstetric blood loss as the fibrinolytic system is known to get activated after placental delivery. OBJECTIVES: To evaluate the efficacy of parenteral tranexamic acid in reducing blood loss during normal labour and to compare it with the amount of blood loss in patients who received placebo in the third stage of labour. METHODOLOGY: Patients with spontaneous labour or planned for induction of labour and fulfilling the inclusion criteria were recruited for the study...
October 2016: Journal of Obstetrics and Gynaecology of India
https://www.readbyqxmd.com/read/27623758/ankle-brachial-index-for-the-diagnosis-of-lower-limb-peripheral-arterial-disease
#19
Fay Crawford, Karen Welch, Alina Andras, Francesca M Chappell
BACKGROUND: Peripheral arterial disease (PAD) of the lower limb is common, with prevalence of both symptomatic and asymptomatic disease estimated at 13% in the over 50 age group. Symptomatic PAD affects about 5% of individuals in Western populations between the ages of 55 and 74 years. The most common initial symptom of PAD is muscle pain on exercise that is relieved by rest and is attributed to reduced lower limb blood flow due to atherosclerotic disease (intermittent claudication). The ankle brachial index (ABI) is widely used by a variety of healthcare professionals, including specialist nurses, physicians, surgeons and podiatrists working in primary and secondary care settings, to assess signs and symptoms of PAD...
September 14, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27575303/coronary-exercise-hyperemia-is-impaired-in-patients-with-peripheral-arterial-disease
#20
Amanda J Ross, Zhaohui Gao, Jonathan Carter Luck, Cheryl A Blaha, Aimee E Cauffman, Faisal Aziz, John F Radtka, David N Proctor, Urs A Leuenberger, Lawrence I Sinoway, Matthew D Muller
BACKGROUND: Peripheral arterial disease (PAD) is an atherosclerotic vascular disease that affects over 200 million people worldwide. The hallmark of PAD is ischemic leg pain and this condition is also associated with an augmented blood pressure response to exercise, impaired vascular function, and high risk of myocardial infarction and cardiovascular mortality. In this study, we tested the hypothesis that coronary exercise hyperemia is impaired in PAD. METHODS: Twelve patients with PAD and no overt coronary disease (65 ± 2 years, 7 men) and 15 healthy control subjects (64 ± 2 years, 9 men) performed supine plantar flexion exercise (30 contractions/min, increasing workload)...
January 2017: Annals of Vascular Surgery
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