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PAD AND blood pressure

Nicholas T Kruse, Kenichi Ueda, William E Hughes, Darren P Casey
Peripheral arterial disease (PAD) is characterized by a reduced blood flow (BF) and elevated blood pressure (pressor) response during lower extremity exercise. Although PAD is evident in the upper extremities no studies have determined BF and pressor responses during upper extremity exercise in PAD. Emerging evidence suggests that inorganic nitrate (NO3 ) supplementation may serve as an alternative dietary strategy to boost nitric oxide bioavailability, improving exercising BF and pressor responses during exercise...
March 9, 2018: American Journal of Physiology. Heart and Circulatory Physiology
Shaolei Ma, Yujie Wang, Xiangrong Zuo, Jing Yao, Quan Cao
OBJECTIVE: To explore the effect of acute respiratory distress syndrome (ARDS) induced by endotoxin on the right ventricular function in rats. METHODS: Sixty male Sprague-Dawley (SD) rats were randomly divided into normal saline (NS) control group and lipopolysaccharide (LPS) model group with 30 rats in each group. The rat model of ARDS was reproduced by intratracheal instillation of LPS 10 mg/kg after tracheotomy, and the rats in NS control group was intratracheally given the same volume of NS instead of LPS...
March 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
Jong Wook Kim, Hyun Ju Kim, Young Joo Park, Sung G Kang, Jae Y Park, Jae Hyun Bae, Seok Ho Kang, Hong Seok Park, Du Geon Moon, Jun Cheon, Jeong Gu Lee, Je Jong Kim, Mi Mi Oh
AIMS: Although generally well tolerated, a urodynamic study is an unpleasant and stressful procedure for some patients. This study evaluated the effects of a heating pad on anxiety, pain, and distress during urodynamic studies in female patients with stress urinary incontinence. METHODS: A total of 74 female patients with stress urinary incontinence who underwent a urodynamic study between May 2015 and October 2015 were randomized to either the experimental group using a heating pad (n = 37) or control group (n = 37)...
March 8, 2018: Neurourology and Urodynamics
Costas Tsioufis, Ioannis Andrikou, Gerasimos Siasos, Konstantinos Filis, Dimitrios Tousoulis
Peripheral artery disease (PAD) affects more than 200 million people worldwide. Hypertension has been related to increased risk of PAD. The treatment of elevated blood pressure (BP) in these patients is indicated to lower the cardiovascular risk with a BP goal of less than 130/80mmHg. Although there is no evidence that one class of antihypertensive medication or strategy is superior for BP lowering in PAD, the use of renin-angiotensin-system (RAS) inhibitors can be effective to reduce the cardiovascular risk...
February 16, 2018: Current Opinion in Pharmacology
Jihong Xing, Jian Lu, Jiahao Liu, Jianhua Li
The exercise pressor reflex is amplified in patients with peripheral artery disease (PAD) and in an experimental PAD model of rats induced by femoral artery occlusion. Heightened blood pressure worsens the restricted blood flow directed to the limbs in this disease. The purpose of this study was to determine the role played by muscle oxidative stress in regulating the augmented pressor response to static exercise in PAD. We hypothesized that limb ischemia impairs muscle superoxide dismutase (SOD) thereby leading to abnormal autonomic responsiveness observed in PAD animals, and a chronic compensation of SOD for anti-oxidation improves the exaggerated exercise pressor reflex...
2018: Frontiers in Physiology
Ling Sun, Ting Zou, Bao-Zhu Wang, Fen Liu, Qing-Hua Yuan, Yi-Tong Ma, Xiang Ma
OBJECTIVES: The prevalence of and risk factors for IAD among different ethnicity groups was unknown. Our aim was to investigate the prevalence of and risk factors for IAD among Han, Uygur and Kazakh ethnicities in Xinjiang. China. METHODS: In total, 14,618 adult participants (7,799 males and 6,819 females) were recruited from the Cardiovascular Risk Survey. A 4-stage stratified cluster random sampling method was used. The participants' personal information and medical history were assessed by questionnaire...
2018: PloS One
Zuowei Duan, Lihong Tao, Tieyu Tang, Changbiao Fu, Jiangbing Liu, Bin Chen, Zhensheng Liu, Haifeng Zhang, Yihui Liu, Xinjiang Zhang
Background and purpose: Early neurological deterioration (END) is not uncommon in acute single small subcortical infarct (SSSI), especially in those with parental arterial disease (PAD). The purpose of this study was to elucidate the effect of BP variability on the development of END as well as functional outcome at 90 days in SSSI and to determine whether the effect is linked to the status of parent artery. Methods: Consecutive patients with acute SSSI were prospectively recruited from the First People's Hospital of Yangzhou between Aug 2013 and Jul 2016...
September 2017: ENeurologicalSci
Eduardo Gustavo Pires de Arruda, Alexandre Mendonça Munhoz, Walter Matsumoto, Thiago Ueda, Renata de Almeida Coudry, Rolf Gemperli
PURPOSE: To evaluate the feasibility of an experimental model of autologous fat graft (AFG) in different interstitial pressure (IP) environments. METHODS: Three mini-pigs(Minipig-BR) with age of 8 months (weight: 25-30 kg) were used. AFG were collected from the bucal fat pad, and grafted in the intramuscular pocket (biceps femoralis muscle). IP model was based on a fusiform ressection followed by primary closure "under tension". A blood pressure catheter located in the intramuscular region connected to a pressure module was applied to quantify IP...
November 2017: Acta Cirúrgica Brasileira
Rashad Zayat, Andreas Goetzenich, Ju-Yeon Lee, HeeJung Kang, So-Hyun Jansen-Park, Thomas Schmitz-Rode, Giulia Musetti, Heike Schnoering, Rüdiger Autschbach, Nima Hatam, Ali Aljalloud
Background: Bedside non-invasive techniques, such as radial artery tonometry, to estimate hemodynamic parameters have gained increased relevance as an attractive alternative and efficient method to measure hemodynamics in outpatient departments. For our pilot study, we sought to compare cardiac output (CO), and stroke volume (SV) estimated from a radial artery tonometry blood pressure pulse analyzer (BPPA) (DMP-Life, DAEYOMEDI Co., Gyeonggi-do, South Korea) to pulsed-wave Doppler (PWD) echocardiography derived parameters...
2017: PeerJ
Udayakumar Karthika Priyadharshini, Radhakrishnan Latha, Ukkirapandian Kavitha, Natarajan Nirmala
Introduction: Indiscriminate use and improper handling of synthetic pesticides in agriculture have resulted in serious problems such as asthma, wheeze and chronic bronchitis among the farmers. Though number of studies have been done on pesticide exposure and its effect on cardiorespiratory parameters in Northern India, only few studies were done in Southern India, thus this study was chosen. Aim: To find the cardiorespiratory changes in farm workers exposed to organophosphorus pesticides...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
Ryan A Becker, Kim Cluff, Nithyanandhi Duraisamy, George P Casale, Iraklis I Pipinos
BACKGROUND: Peripheral artery disease (PAD) is a vascular disease caused by atherosclerosis, resulting in decreased blood flow to the lower extremities. The ankle-brachial index (ABI) is a standard PAD diagnostic test but only identifies reduced blood flow based on blood pressure differences. The early signs of PAD manifest themselves not only at a clinical level but also at an elemental and biochemical level. However, the biochemical and elemental alterations to PAD muscle are not well understood...
December 2017: Journal of Surgical Research
X Yu, J Tan, S L Diamond
Essentials Neutrophil extracellular traps (NETs) are generated during thrombosis and sepsis. The effect of hemodynamics on NETosis during sterile thrombosis was studied using microfluidics. Pressure gradients > 70 mmHg per mm-clot across sterile occlusions drive shear-induced NETosis. High interstitial hemodynamic forces trigger rapid NET release. SUMMARY: Background Neutrophil extracellular traps (NETs) are released when neutrophils encounter infectious pathogens, especially during sepsis...
February 2018: Journal of Thrombosis and Haemostasis: JTH
Jihong Xing, Jianhua Li
BACKGROUND/AIMS: Limb ischemia occurs in peripheral artery disease (PAD). Sympathetic nerve activity (SNA) that regulates blood flow directed to the ischemic limb is exaggerated during exercise in this disease, and transient receptor potential channel A1 (TRPA1) in thin-fiber muscle afferents contributes to the amplified sympathetic response. The purpose of the present study was to determine the role of proteinase-activated receptor-2 (PAR2) in regulating abnormal TRPA1 function and the TRPA1-mediated sympathetic component of the exercise pressor reflex...
2017: Cellular Physiology and Biochemistry
Ángel Herráiz-Adillo, Alba Soriano-Cano, José Alberto Martínez-Hortelano, Miriam Garrido-Miguel, Julián Ángel Mariana-Herráiz, Vicente Martínez-Vizcaíno, Blanca Notario-Pacheco
PURPOSE: Inter-arm systolic blood pressure differences (IASBPD) and inter-leg systolic blood pressure differences (ILSBPD) have arisen as potential tools to detect peripheral artery disease (PAD) and individuals at high cardiovascular risk. This study aims to evaluate the diagnostic accuracy of IASBPD and ILSBPD to detect PAD, and whether IASBPD or ILSBPD improves diagnostic accuracy of the oscillometric ankle-brachial index (ABI). MATERIALS AND METHODS: In this prospective study, eligible for inclusion were consecutive adults, with at least one of the following cardiovascular risk factors: diabetes, dyslipidemia, hypertension, smoking habit or age ≥65...
November 10, 2017: Blood Pressure
V Cornejo Del Río, J Mostaza, C Lahoz, V Sánchez-Arroyo, C Sabín, S López, P Patrón, P Fernández-García, B Fernández-Puntero, D Vicent, L Montesano-Sánchez, F García-Iglesias, T González-Alegre, E Estirado, F Laguna, C de Burgos-Lunar, P Gómez-Campelo, J C Abanades-Herranz, J M de Miguel-Yanes, M A Salinero-Fort
AIM: To describe the prevalence of Peripheral Artery Disease (PAD) in a random population sample and to evaluate its relationship with Mediterranean diet and with other potential cardiovascular risk factors such as serum uric acid and pulse pressure in individuals ranged 45 to 74 years. METHODS: Cross-sectional analysis of 1568 subjects (mean age 6.5 years, 43% males), randomly selected from the population. A fasting blood sample was obtained to determine glucose, lipids, and HbA1C levels...
2017: PloS One
Evan A Kempf, Korynne S Rollins, Tyler D Hopkins, Alec L Butenas, Joseph M Santin, Joshua R Smith, Steven W Copp
Mechanical and metabolic signals arising during skeletal muscle contraction reflexly increase sympathetic nerve activity and blood pressure (i.e., the exercise pressor reflex). In a rat model of simulated peripheral artery disease (PAD) in which a femoral artery is chronically (~72 hours) ligated, the mechanically-sensitive component of the exercise pressor reflex during 1 Hz dynamic contraction is exaggerated compared to that found in normal rats. Whether this is due to an enhanced acute sensitization of mechanoreceptors by metabolites produced during contraction or involves a chronic sensitization of mechanoreceptors is unknown...
October 20, 2017: American Journal of Physiology. Heart and Circulatory Physiology
J Matthew Kuczmarski, Kellee Unrath, Gail D Thomas
Patients with atherosclerotic peripheral artery disease (PAD) have an augmented pressor response to treadmill walking, but the underlying mechanisms remain poorly understood and difficult to isolate due to the confounding presence of numerous cardiovascular risk factors. In this study, we tested the hypothesis that a chronic deficit in muscle blood flow capacity would be sufficient to trigger an exaggerated pressor response to dynamic exercise. Sprague Dawley rats (5 male, 5 female) were instrumented with radiotelemetery devices in order to measure the cardiovascular responses to treadmill running before and after bilateral femoral artery ligation, which has been shown previously to reduce the blood flow capacity of the distal hindlimb muscles by >60%...
October 6, 2017: American Journal of Physiology. Heart and Circulatory Physiology
R C Price, W Gandhi, C Nadeau, R Tarnavskiy, A Qu, E Fahey, L Stone, P Schweinhardt
BACKGROUND: Human experimental pain models provide an important translational link between pre-clinical models and clinical pain. Using topical capsaicin and continuous heat application, the novel capsaicin/heat ongoing pain (CHOP) model induces long-lasting experimental pain of which the perceived intensity can be individually adjusted. METHODS: In the CHOP model, capsaicin or control cream is applied to a 10 × 10 cm skin area and a heating pad is applied over the area after cream removal...
October 6, 2017: European Journal of Pain: EJP
Agnes Keszler, Brian Lindemer, Dorothee Weihrauch, Deron Jones, Neil Hogg, Nicole L Lohr
Peripheral artery disease (PAD) is a morbid condition whereby ischemic peripheral muscle causes pain and tissue breakdown. Interestingly, PAD risk factors, e.g. diabetes mellitus, cause endothelial dysfunction secondary to decreased nitric oxide (NO) levels, which could explain treatment failures. Previously, we demonstrated 670nm light (R/NIR) increased NO from nitrosyl-heme stores, therefore we hypothesized R/NIR can stimulate vasodilation in healthy and diabetic blood vessels. Vasodilation was tested by ex vivo pressure myography in wild type C57Bl/6, endothelial nitric oxide synthase (eNOS) knockout, and db/db mice (10mW/cm2 for 5min with 10min dark period)...
December 2017: Free Radical Biology & Medicine
Juan Tang, Tao Li, Pinhong Li, Yuefei Ma, Momo Liu, Qiaoyun Shan, Fengqi Guo, Ting Zhou, Qianping Wei
BACKGROUNDS: There is still a lack of consensus about how to assess the risk of peripheral arterial disease (PAD) and cardiovascular disease (CVD) in patients with diabetic retinopathy (DR). AIMS: We investigated the risk factors for DR and their association with PAD and CVD in patients with type 2 diabetes (T2D). METHODS: A total of 1,421 patients diagnosed with T2D participated in this study. DR stages were classified as non-DR, nonproliferative DR (NPDR), or proliferative DR (PDR)...
September 21, 2017: Ophthalmic Research
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