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https://www.readbyqxmd.com/read/27894602/evolution-and-degree-of-control-of-cardiovascular-risk-factors-after-5-years-of-follow-up-and-their-relationship-with-the-incidence-of-peripheral-arterial-disease-artper-cohort
#1
Rosa Forés, María Teresa Alzamora, Guillem Pera, Marta Valverde, Maria Angla, José Miguel Baena-Díez, Xavier Mundet-Tuduri
BACKGROUND AND OBJECTIVE: Although cardiovascular risk factors (CVRF) are well known, their degree of control is not optimal. The aim of this study is to assess the evolution and control of CVRFs after 5 years of monitoring a population-based cohort and their association with the incidence of peripheral arterial disease (PAD). MATERIAL AND METHOD: Prospective cohort study recruited between 2006-2008. Second phase between 2011-2012. An ankle brachial index was determined for all participants in both phases...
November 25, 2016: Medicina Clínica
https://www.readbyqxmd.com/read/27873008/arterial-stiffness-and-peripheral-arterial-disease-in-patients-with-systemic-lupus-erythematosus
#2
Konstantinos Tziomalos, Ioannis Gkougkourelas, Alexandros Sarantopoulos, Eleni Bekiari, Evangelia Makri, Nikolaos Raptis, Konstantinos Tselios, Marianna Pantoura, Apostolos I Hatzitolios, Panagiota Boura
Systemic lupus erythematosus (SLE) is associated with increased cardiovascular risk. We aimed to evaluate arterial stiffness and the ankle brachial index (ABI), two markers of subclinical cardiovascular disease, in SLE. We studied 55 patients with SLE (12.7% males, age 53.3 ± 15.3 years) and 61 age- and gender-matched controls. Arterial stiffness was evaluated by measuring pulse wave velocity (PWV), augmentation index (AIx) and central systolic, diastolic, pulse and mean blood pressure (BP). Peripheral arterial disease was defined as ABI ≤ 0...
November 21, 2016: Rheumatology International
https://www.readbyqxmd.com/read/27830155/high-systolic-and-diastolic-blood-pressure-variability-is-correlated-with-the-occurrence-of-peripheral-arterial-disease-in-the-first-decade-following-a-diagnosis-of-type-2-diabetes-mellitus-a-new-biomarker-from-old-measurement
#3
Chi-Hsiao Yeh, Hsiu-Chin Yu, Tzu-Yen Huang, Pin-Fu Huang, Yao-Chang Wang, Tzu-Ping Chen, Shun-Ying Yin
Background. To assess whether the visit-to-visit variability in blood pressure (BP) is a risk factor of peripheral arterial disease (PAD) in patients with type 2 diabetes mellitus (T2DM) 10 years after diagnosis. Methods. The electronic medical records of 825 patients, who were diagnosed with type 2 diabetes mellitus (T2DM) during 2000-2002 and regularly followed for 10 years, were retrospectively reviewed. A total of 53,284 clinic visit records, including analysis of BP, BMI, serum glycohemoglobin, and lipid profile, were analyzed...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27805541/inulin-oligofructose-attenuates-metabolic-syndrome-in-high-carbohydrate-high-fat-diet-fed-rats
#4
Senthil A Kumar, Leigh C Ward, Lindsay Brown
Prebiotics alter bacterial content in the colon, and therefore could be useful for obesity management. We investigated the changes following addition of inulin oligofructose (IO) in the food of rats fed either a corn starch (C) diet or a high-carbohydrate, high-fat (H) diet as a model of diet-induced metabolic syndrome. IO did not affect food intake, but reduced body weight gain by 5·3 and 12·3 % in corn starch+inulin oligofructose (CIO) and high-carbohydrate, high-fat with inulin oligofructose (HIO) rats, respectively...
November 2016: British Journal of Nutrition
https://www.readbyqxmd.com/read/27760183/a-novel-index-using-ankle-hemodynamic-parameters-to-assess-the-severity-of-peripheral-arterial-disease-a-pilot-study
#5
Jun Tanno, Yodo Gatate, Takatoshi Kasai, Shintaro Nakano, Takaaki Senbonmatsu, Osamu Sato, Shigeru Ichioka, Makoto Kuro-O, Shigeyuki Nishimura
In peripheral arterial disease (PAD) of the lower extremities, the presence of flow-limiting stenoses can be objectively detected by the ankle-brachial index (ABI). However, the severity of ischemic symptoms is not necessarily associated with the ABI value. Atherosclerotic plaque in lower extremity PAD induces ankle arterial stiffness and reduces ankle vascular resistance, which may decrease ankle blood flow and cause ischemic symptoms. We hypothesized that the ankle hemodynamic index (AHI), defined as the ratio of ankle arterial stiffness to ankle vascular resistance, could be used to assess the blood supply deficiency in a diseased lower limb in patients with PAD...
2016: PloS One
https://www.readbyqxmd.com/read/27693032/an-endovascular-model-of-ischemic-myopathy-from-peripheral-arterial-disease
#6
Chandler A Long, Lucas H Timmins, Panagiotis Koutakis, Traci T Goodchild, David J Lefer, Iraklis I Pipinos, George P Casale, Luke P Brewster
OBJECTIVE: Peripheral arterial disease (PAD) is a significant age-related medical condition with limited pharmacologic options. Severe PAD, termed critical limb ischemia, can lead to amputation. Skeletal muscle is the end organ most affected by PAD, leading to ischemic myopathy and debility of the patient. Currently, there are not any therapeutics to treat ischemic myopathy, and proposed biologic agents have not been optimized owing to a lack of preclinical models of PAD. Because a large animal model of ischemic myopathy may be useful in defining the optimal dosing and delivery regimens, the objective was to create and to characterize a swine model of ischemic myopathy that mimics patients with severe PAD...
September 29, 2016: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/27689831/noninvasive-physiologic-vascular-studies-a-guide-to-diagnosing-peripheral-arterial-disease
#7
Robert C Sibley, Stephen P Reis, Jarrod J MacFarlane, Mark A Reddick, Sanjeeva P Kalva, Patrick D Sutphin
Noninvasive physiologic vascular studies play an important role in the diagnosis and characterization in peripheral arterial disease (PAD) of the lower extremity. These studies evaluate the physiologic parameters of blood flow through segmental arterial pressures, Doppler waveforms, and pulse volume recordings. Collectively, they comprise a powerful toolset for defining the functionality of the arterial system, localizing the site of disease, and providing prognostic data. This technology has been widely adopted by diverse medical specialty practitioners, including radiologists, surgeons, cardiologists, and primary care providers...
September 30, 2016: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/27689032/association-between-vitamin-d-status-and-risk-of-peripheral-arterial-disease-the-dong-gu-study
#8
Su-Hyun Oh, Sun-Seog Kweon, Jin-Su Choi, Jung-Ae Rhee, Young-Hoon Lee, Hae-Sung Nam, Seul-Ki Jeong, Kyeong-Soo Park, So-Yeon Ryu, Seong-Woo Choi, Min-Ho Shin
Low levels of vitamin D have been associated with increased cardiovascular disease risk. However, few studies have evaluated the association between vitamin D status and peripheral arterial disease (PAD). We therefore aimed to investigate whether low 25-hydroxyvitamin D (25(OH)D) levels were associated with increased risk of PAD in the Korean population. This cross-sectional study was conducted among 8,960 subjects aged 50 years or older without known myocardial infarction or stroke. PAD was defined by an ankle brachial blood pressure index <0...
September 2016: Chonnam Medical Journal
https://www.readbyqxmd.com/read/27651612/role-of-tranexamic-acid-in-reducing-blood-loss-in-vaginal-delivery
#9
Priyankur Roy, M S Sujatha, Ambarisha Bhandiwad, Bivas Biswas
INTRODUCTION: Anti-fibrinolytic agents are used to reduce obstetric blood loss as the fibrinolytic system is known to get activated after placental delivery. OBJECTIVES: To evaluate the efficacy of parenteral tranexamic acid in reducing blood loss during normal labour and to compare it with the amount of blood loss in patients who received placebo in the third stage of labour. METHODOLOGY: Patients with spontaneous labour or planned for induction of labour and fulfilling the inclusion criteria were recruited for the study...
October 2016: Journal of Obstetrics and Gynaecology of India
https://www.readbyqxmd.com/read/27623758/ankle-brachial-index-for-the-diagnosis-of-lower-limb-peripheral-arterial-disease
#10
Fay Crawford, Karen Welch, Alina Andras, Francesca M Chappell
BACKGROUND: Peripheral arterial disease (PAD) of the lower limb is common, with prevalence of both symptomatic and asymptomatic disease estimated at 13% in the over 50 age group. Symptomatic PAD affects about 5% of individuals in Western populations between the ages of 55 and 74 years. The most common initial symptom of PAD is muscle pain on exercise that is relieved by rest and is attributed to reduced lower limb blood flow due to atherosclerotic disease (intermittent claudication). The ankle brachial index (ABI) is widely used by a variety of healthcare professionals, including specialist nurses, physicians, surgeons and podiatrists working in primary and secondary care settings, to assess signs and symptoms of PAD...
September 14, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27575303/coronary-exercise-hyperemia-is-impaired-in-patients-with-peripheral-arterial-disease
#11
Amanda J Ross, Zhaohui Gao, Jonathan Carter Luck, Cheryl A Blaha, Aimee E Cauffman, Faisal Aziz, John F Radtka, David N Proctor, Urs A Leuenberger, Lawrence I Sinoway, Matthew D Muller
BACKGROUND: Peripheral arterial disease (PAD) is an atherosclerotic vascular disease that affects over 200 million people worldwide. The hallmark of PAD is ischemic leg pain and this condition is also associated with an augmented blood pressure response to exercise, impaired vascular function, and high risk of myocardial infarction and cardiovascular mortality. In this study, we tested the hypothesis that coronary exercise hyperemia is impaired in PAD. METHODS: Twelve patients with PAD and no overt coronary disease (65 ± 2 years, 7 men) and 15 healthy control subjects (64 ± 2 years, 9 men) performed supine plantar flexion exercise (30 contractions/min, increasing workload)...
August 27, 2016: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/27563616/regeneration-of-mandibular-ameloblastoma-defect-with-the-help-of-autologous-dental-pulp-stem-cells-and-buccal-pad-of-fat-stromal-vascular-fraction
#12
K Manimaran, Rohini Sharma, S Sankaranarayanan, S Mahendra Perumal
Ameloblastoma is benign odontogenic tumor, which is locally aggressive in behavior. Till date, the treatment of choice is resection and reconstruction using a variety of modalities. Inadequate resection may lead to many complications such as bone deformity and dysfunction. This report is about a 14-year-old male with ameloblastoma treated with autologous dental pulp stem cells (DPSCs) and stromal vascular fraction (SVF) and evidence of bone regeneration. Marsupialization was performed; tooth was extracted and sent for DPSC cultivation...
January 2016: Annals of Maxillofacial Surgery
https://www.readbyqxmd.com/read/27553104/risk-factor-optimization-and-guideline-directed-medical-therapy-in-us-veterans-with-peripheral-arterial-and-ischemic-cerebrovascular-disease-compared-to-veterans-with-coronary-heart-disease
#13
Ravi S Hira, Jennifer B Cowart, Julia M Akeroyd, David J Ramsey, Yashashwi Pokharel, Vijay Nambi, Hani Jneid, Anita Deswal, Ali Denktas, Addison Taylor, Khurram Nasir, Christie M Ballantyne, Laura A Petersen, Salim S Virani
Cardiovascular disease (CVD) is a systemic process involving multiple vascular beds and includes coronary heart disease (CHD), ischemic cerebrovascular disease (ICVD), and peripheral arterial disease (PAD). All these manifestations are associated with an increased risk of subsequent myocardial infarction, stroke, and death. Guideline-directed medical therapy is recommended for all patients with CVD. In a cohort of US veterans, we identified 1,242,015 patients with CVD receiving care in 130 Veterans Affairs facilities from October 1, 2013 to September 30, 2014...
October 15, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/27536125/detection-of-peripheral-arterial-disease-with-an-improved-automated-device-comparison-of-a-new-oscillometric-device-and-the-standard-doppler-method
#14
Matjaž Špan, Gregor Geršak, Sandrine C Millasseau, Marko Meža, Andrej Košir
In occidental countries, peripheral arterial disease (PAD) is an important health issue; however, most subjects are asymptomatic (~50%) and therefore undiagnosed and untreated. Current guidelines recommend screening for PAD in primary care setting using ankle brachial index (ABI) in all patients with cardiovascular risks. This is, however, not performed strictly because the standard Doppler method is cumbersome and time-consuming. Here, we evaluate the accuracy and reproducibility of ABI measurements obtained by an improved automated oscillometric device, the MESI ABPI MD(®) device, and the standard Doppler method...
2016: Vascular Health and Risk Management
https://www.readbyqxmd.com/read/27531043/relationship-between-limited-joint-mobility-of-hand-and-diabetic-foot-risk-in-patients-with-type-2-diabetes
#15
Yusuke Mineoka, Michiyo Ishii, Akiko Tsuji, Yoriko Komatsu, Yuko Katayama, Mitsuko Yamauchi, Aki Yamashita, Yoshitaka Hashimoto, Naoto Nakamura, Yasukazu Katsumi, Motohide Isono, Michiaki Fukui
BACKGROUND: Foot ulceration is a serious problem for patients with type 2 diabetes and early detection of risks for this condition is important for preventing complications. We conducted a cross-sectional study in patients with type 2 diabetes to determine the relationship between limited joint mobility (LJM) of hand and diabetic foot risk classified using the criteria of the International Working Group on the Diabetic Foot (IWGDF). METHODS: Relationships of LJM of hand and the foot risk with the IWGDF category, hemoglobin A1c, age, body mass index, blood pressure, estimated glomerular filtration (eGFR), diabetic complications including diabetic peripheral neuropathy (DPN), and peripheral arterial disease (PAD) were evaluated in 528 consecutive patients with type 2 diabetes...
August 16, 2016: Journal of Diabetes
https://www.readbyqxmd.com/read/27526424/-cardio-vascular-risk-factors-control-in-elderly-patients-with-peripheral-artery-disease
#16
Dorota Studzińska, Barbara Gryglewska, Maria Wojnarowska, Joanna Paleń, Bogusław Rudel, Tomasz Grodzicki
OBJECTIVE: The assessment of control of modifiable risk factors among elderly patients with peripheral artery disease (PAD) admitted to the hospital angiology ward. METHODS: The results of treatment of dyslipidemia (DL), hypertension (HT), diabetes mellitus (DM) and prevalence of cigarette smoking were assessed among older (>65 years old, group I) and younger patients (group II) with PAD in a admission day to hospital. RESULTS: The study population included 154 patients (I--92 and II--65 subjects) aged 67...
2016: Przegla̧d Lekarski
https://www.readbyqxmd.com/read/27522380/the-improvement-of-walking-abilities-and-endothelial-function-after-the-supervised-training-treadmill-program-sttp-in-patients-with-peripheral-artery-disease-pad-is-not-related-to-prostacyclin-and-thromboxane-release
#17
Rafał Januszek, Piotr Mika, Roman Nowobilski, Paweł Maga, Rafał Niżankowski
BACKGROUND: In this prospective study we evaluated the relationship between thromboxane B2 (TXB2), prostacyclin (PGI2) and lactate concentrations, and the improvement of walking abilities and endothelial function in patients with peripheral artery disease (PAD) undergoing a supervised treadmill training program (STTP). METHODS: A total of fifty-nine patients with stable intermittent claudication were included into a 12-week long STTP. Changes in blood pressure, biochemical parameters, ankle/brachial index (ABI), flow-mediated dilatation (FMD), maximal walking time (MWT) and pain-free walking time (PFWT) were assessed before and after STTP...
November 1, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27469399/intra-abdominal-packing-with-laparotomy-pads-and-quikclot%C3%A2-during-damage-control-laparotomy-a-safety-analysis
#18
Rachel L Choron, Joshua P Hazelton, Krystal Hunter, Lisa Capano-Wehrle, John Gaughan, John Chovanes, Mark J Seamon
BACKGROUND: Intra-abdominal packing with laparotomy pads (LP) is a common and rapid method for hemorrhage control in critically injured patients. Combat Gauze™ and Trauma Pads™ ([QC] Z-Medica QuikClot(®)) are kaolin impregnated hemostatic agents, that in addition to LP, may improve hemorrhage control. While QC packing has been effective in a swine liver injury model, QC remains unstudied for human intra-abdominal use. We hypothesized QC packing during damage control laparotomy (DCL) better controls hemorrhage than standard packing and is safe for intracorporeal use...
July 21, 2016: Injury
https://www.readbyqxmd.com/read/27428501/adaptation-of-external-counterpulsation-based-on-individual-shear-rate-therapy-improves-endothelial-function-and-claudication-distance-in-peripheral-artery-disease
#19
Eva-Elina Buschmann, Michele Brix, Lulu Li, Janke Doreen, Andreas Zietzer, Meijing Li, Ivo Buschmann, Philipp Hillmeister
BACKGROUND: External counterpulsation therapy enhances blood flow and was shown to improve endothelial function and quality of life in coronary artery disease patients. However, high pressures of up to 300 mmHg may lead to malperfusion of the ischaemic limb. To improve the clinical outcome of patients with peripheral artery disease (PAD), we adjusted external counterpulsation and developed a novel non-invasive approach termed individual shear rate therapy (ISRT). PATIENTS AND METHODS: In the present study, 14 patients with a Fontaine stage IIb and femoral-popliteal PAD underwent 30 hours of ISRT over 5 weeks...
2016: VASA. Zeitschrift Für Gefässkrankheiten
https://www.readbyqxmd.com/read/27387019/high-circulating-osteoprotegerin-levels-are-associated-with-non-zero-blood-groups
#20
Elod Erno Nagy, Timea Varga-Fekete, Attila Puskas, Piroska Kelemen, Zoltan Brassai, Katalin Szekeres-Csiki, Timea Gombos, Maria Csilla Csanyi, Jolan Harsfalvi
BACKGROUND: Osteoprotegerin (OPG) and von Willebrand factor (VWF) form complex within endothelial cells and following secretion. The nature of blood group antigens strongly influences the levels of circulating VWF, but there is no available data concerning its ascendancy on OPG levels. We aimed to assess the relationship of AB0 blood groups with OPG, VWF levels (VWF: Ag) and collagen binding activity (VWF: CB) in peripheral arterial disease (PAD) patients. METHODS: Functional and laboratory parameters of 105 PAD patients and 109 controls were examined...
2016: BMC Cardiovascular Disorders
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