Bin Qiao, Xinye Song, Weiyi Zhang, Ming Xu, Bowen Zhuang, Wei Li, Huanling Guo, Wenxin Wu, Guangliang Huang, Minru Zhang, Xiaoyan Xie, Nan Zhang, Yong Luan, Chunyang Zhang
BACKGROUND: The lack of a satisfactory strategy for postoperative pain management significantly impairs the quality of life for many patients. However, existing nanoplatforms cannot provide a longer duration of nerve blockage with intensity-adjustable characteristics under imaging guidance for clinical applications. RESULTS: To overcome this challenge, we proposed a biocompatible nanoplatform that enables high-definition ultrasound imaging-guided, intensity-adjustable, and long-lasting analgesia in a postoperative pain management model in awake mice...
November 24, 2022: Journal of Nanobiotechnology