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Pharmaceutical nanocrystals

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https://www.readbyqxmd.com/read/28629862/sustained-delivery-of-bsa-hsa-from-biocompatible-plant-cellulose-nanocrystals-for-in-vitro-cholesterol-release-from-endothelial-cells
#1
Rubbel Singla, Sourabh Soni, Yogendra S Padwad, Amitabha Acharya, Sudesh Kumar Yadav
Nanocomposites of plant cellulose nanocrystals (CNCs) were developed by binding model proteins BSA and HSA onto CNCs by physical adsorption and chemical conjugation methods The spectroscopy and microscopy studies confirmed the protein binding onto CNCs. Phosphate buffer saline (pH=4.0, 7.4) and simulated gastric and intestinal fluids (SGF/SIF; pH=1.1/6.5) showed maximum protein release of ∼62% over a period of time. The released proteins were found to retain both structural integrity as well as≥90% of bioactivity...
June 16, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28603030/nanosizing-techniques-for-improving-bioavailability-of-drugs
#2
REVIEW
Raida Al-Kassas, Mahima Bansal, John Shaw
The poor solubility of significant number of Active Pharmaceutical Ingredients (APIs) has become a major challenge in the drug development process. Drugs with poor solubility are difficult to formulate by conventional methods and often show poor bioavailability. In the last decade, attention has been focused on developing nanocrystals for poorly water soluble drugs using nanosizing techniques. Nanosizing is a pharmaceutical process that changes the size of a drug to the sub-micron range in an attempt to increase its surface area and consequently its dissolution rate and bioavailability...
June 8, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28585942/progress-of-crystallization-in-microfluidic-devices
#3
REVIEW
Huan-Huan Shi, Yan Xiao, Steven Ferguson, Xin Huang, Na Wang, Hong-Xun Hao
Microfluidic technology provides a unique environment for the investigation of crystallization processes at the nano or meso scale. The convenient operation and precise control of process parameters, at these scales of operation enabled by microfluidic devices, are attracting significant and increasing attention in the field of crystallization. In this paper, developments and applications of microfluidics in crystallization research including: crystal nucleation and growth, polymorph and cocrystal screening, preparation of nanocrystals, solubility and metastable zone determination, are summarized and discussed...
June 6, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28530283/composite-cd-mof-nanocrystals-containing-microspheres-for-sustained-drug-delivery
#4
Haiyan Li, Nana Lv, Xue Li, Botao Liu, Jing Feng, Xiaohong Ren, Tao Guo, Dawei Chen, J Fraser Stoddart, Ruxandra Gref, Jiwen Zhang
Metal-organic frameworks (MOFs), which are typically embedded in polymer matrices as composites, are emerging as a new class of carriers for sustained drug delivery. Most of the MOFs and the polymers used so far in these composites, however, are not pharmaceutically acceptable. In the investigation reported herein, composites of γ-cyclodextrin (γ-CD)-based MOFs (CD-MOFs) and polyacrylic acid (PAA) were prepared by a solid in oil-in-oil (s/o/o) emulsifying solvent evaporation method. A modified hydrothermal protocol has been established which produces efficiently at 50 °C in 6 h micron (5-10 μm) and nanometer (500-700 nm) diameter CD-MOF particles of uniform size with smooth surfaces and powder X-ray diffraction patterns that are identical with those reported in the literature...
June 8, 2017: Nanoscale
https://www.readbyqxmd.com/read/28527464/-14-n-nqr-lineshape-in-nanocrystals-an-ab-initio-investigation-of-urea
#5
Alan Gregorovič
(14)N nuclear quadrupole resonance (NQR) lineshapes mostly contain information of low interest, although in nanocrystals they may display some unexpected behaviour. In this work, we present an ab initio computational study of the (14)N NQR lineshapes in urea nanocrystals as a function of the nanocrystal size and geometry, focusing on the surface induced broadening of the lineshapes. The lineshapes were obtained through a calculation of the electric field gradient for each nitrogen site in the nanocrystal separately, taking into account the individual crystal field by embedding the molecule of interest in a suitable lattice of point multipoles representing other urea molecules in the nanocrystal...
May 21, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28504148/enhanced-emulsifying-properties-of-wood-based-cellulose-nanocrystals-as-pickering-emulsion-stabilizer
#6
Xiaoyu Gong, Yixiang Wang, Lingyun Chen
Cellulose nanocrystals are hydrophilic nanomaterials, which limits their applications as interfacial compounds. Herein, we propose using modified wood-based cellulose nanocrystals as Pickering emulsion stabilizer. Wood cellulose was consecutively oxidized and modified with phenyltrimethylammonium chloride to create hydrophobic domains comprised of phenyl groups. These modified oxidized cellulose nanocrystals (m-O-CNCs) were homogeneous/electrostatically stable in water and they can stabilize O/W Pickering emulsions...
August 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28435075/development-of-oral-lyophilisates-containing-meloxicam-nanocrystals-using-qbd-approach
#7
Sonia Iurian, Cătălina Bogdan, Ioan Tomuță, Piroska Szabó-Révész, Anita Chvatal, Sorin E Leucuța, Mirela Moldovan, Rita Ambrus
The aim of this study was to develop oral lyophilisates with improved meloxicam (MEL) dissolution, optimizing each step of the preparation by design of experiments. First, meloxicam nanosuspensions were prepared by high-pressure homogenization (HPH), using PVP, Poloxamer or PEG as stabilizers and were subjected to freeze-drying using mannitol as cryoprotectant. The effects of the stabilizers and cryoprotectant were assessed and an optimal formulation was generated within the Design Space where the particle sizes and the PDIs are at their lowest values...
June 15, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28281194/development-considerations-for-nanocrystal-drug-products
#8
Mei-Ling Chen, Mathew John, Sau L Lee, Katherine M Tyner
Nanocrystal technology has emerged as a valuable tool for facilitating the delivery of poorly water-soluble active pharmaceutical ingredients (APIs) and enhancing API bioavailability. To date, the US Food and Drug Administration (FDA) has received over 80 applications for drug products containing nanocrystals. These products can be delivered by different routes of administration and are used in a variety of therapeutic areas. To aid in identifying key developmental considerations for these products, a retrospective analysis was performed on the submissions received by the FDA to date...
March 9, 2017: AAPS Journal
https://www.readbyqxmd.com/read/28271901/nanocrystal-dissolution-kinetics-and-solubility-increase-prediction-from-molecular-dynamics-the-case-of-%C3%AE-%C3%AE-and-%C3%AE-glycine
#9
Conor Parks, Andy Koswara, Hsien-Hsin Tung, Nandkishor K Nere, Shailendra Bordawekar, Zoltan K Nagy, Doraiswami Ramkrishna
Nanocrystals are receiving increased attention for pharmaceutical applications due to their enhanced solubility relative to their micron-sized counterpart and, in turn, potentially increased bioavailability. In this work, a computational method is proposed to predict the following: (1) polymorph specific dissolution kinetics and (2) the multiplicative increase in the polymorph specific nanocrystal solubility relative to the bulk solubility. The method uses a combination of molecular dynamics and a parametric particle size dependent mass transfer model...
April 3, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28262608/tailoring-heterostructured-bi2moo6-bi2s3-nanobelts-for-highly-selective-photoelectrochemical-analysis-of-gallic-acid-at-drug-level
#10
Lingnan Wang, Zhenbang Liu, Dandan Wang, Shuang Ni, Dongxue Han, Wei Wang, Li Niu
Along with continuous growing widespread adulterations of botanical drugs, the necessity for drug quality monitoring has become more popular than ever. Considering that antioxidants are widely found in natural plant pharmaceuticals, gallic acid (GA) is often regarded as the reference standard to make sure whether these are up to grade as guided by Chinese Pharmacopeia. Herein, a novel Bi2MoO6/Bi2S3 photoelectrochemical sensor has been successfully involved toward selective GA analysis to supervise drug quality, in which γ-Bi2MoO6 nanobelts were treated as template nanocrystal and scaffold...
February 27, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28194730/preparation-and-in-vitro-in-vivo-characterization-of-trans-resveratrol-nanocrystals-for-oral-administration
#11
Sandeep K Singh, Vishal Makadia, Shweta Sharma, Mamunur Rashid, Sudhir Shahi, Prabhat R Mishra, Mohammed Wahajuddin, Jiaur R Gayen
Trans -resveratrol (t-RES) is a natural polyphenolic compound with extensive therapeutic activities; however, its clinical application is circumscribed due to its poor solubility and low bioavailability. The purpose of this study was to prepare stable t-RES nanocrystals (t-RES-NCs) with different stabilizers to improve its oral bioavailability. t-RES-NCs were fabricated by the probe sonication method and optimized by particles size, poly dispersive index and zeta potential. The pharmaceutical characterization of t-RES-NCs was further performed systematically...
February 13, 2017: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/28116390/recent-progress-in-cellulose-nanocrystals-sources-and-production
#12
REVIEW
Djalal Trache, M Hazwan Hussin, M K Mohamad Haafiz, Vijay Kumar Thakur
Cellulose nanocrystals, a class of fascinating bio-based nanoscale materials, have received a tremendous amount of interest both in industry and academia owing to its unique structural features and impressive physicochemical properties such as biocompatibility, biodegradability, renewability, low density, adaptable surface chemistry, optical transparency, and improved mechanical properties. This nanomaterial is a promising candidate for applications in fields such as biomedical, pharmaceuticals, electronics, barrier films, nanocomposites, membranes, supercapacitors, etc...
February 2, 2017: Nanoscale
https://www.readbyqxmd.com/read/28088572/bcs-class-iv-drugs-highly-notorious-candidates-for-formulation-development
#13
REVIEW
Rohan Ghadi, Neha Dand
BCS class IV drugs (e.g., amphotericin B, furosemide, acetazolamide, ritonavir, paclitaxel) exhibit many characteristics that are problematic for effective oral and per oral delivery. Some of the problems associated include low aqueous solubility, poor permeability, erratic and poor absorption, inter and intra subject variability and significant positive food effect which leads to low and variable bioavailability. Also, most of the class IV drugs are substrate for P-glycoprotein (low permeability) and substrate for CYP3A4 (extensive pre systemic metabolism) which further potentiates the problem of poor therapeutic potential of these drugs...
January 11, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/27842840/properties-of-cellulose-nanocrystals-from-oil-palm-trunk-isolated-by-total-chlorine-free-method
#14
Junidah Lamaming, Rokiah Hashim, Cheu Peng Leh, Othman Sulaiman
Cellulose nanocrystals were isolated from oil palm trunk by total chlorine free method. The samples were either water pre-hydrolyzed or non-water pre-hydrolyzed, subjected to soda pulping, acidified and ozone bleached. Cellulose and cellulose nanocrystal (CNC) physical, chemical, thermal properties, and crystallinity index were investigated by composition analysis, scanning electron microscopy, transmission electron microscopy, fourier transform infrared, thermogravimetric analysis and X-ray diffraction. Water pre-hydrolysis reduced lignin (<0...
January 20, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/27758683/nanocrystal-based-drug-delivery-system-conventional-and-current-scenario
#15
Shreya Thakkar, Viral Shah, Manju Misra, Kiran Kalia
BACKGROUND: Most of the chemical substances which emerge out as potential drug candidates (Active Pharmaceutical Ingredients) are either weak acids or weak bases. Poor aqueous solubility of these drug substances is a common concern. Several R&D centers are focused on developing suitable, economic, simpler and more feasible solubility enhancement techniques for increasing the solubility and thereby bioavailability of such drug substances. Nanocrystals is one of the preferred approaches for solubility enhancement in last few decades...
October 14, 2016: Recent Patents on Nanotechnology
https://www.readbyqxmd.com/read/27558875/pulmonary-exposure-to-cellulose-nanocrystals-caused-deleterious-effects-to-reproductive-system-in-male-mice
#16
Mariana T Farcas, Elena R Kisin, Autumn L Menas, Dmitriy W Gutkin, Alexander Star, Richard S Reiner, Naveena Yanamala, Kai Savolainen, Anna A Shvedova
Over the past several years there has been an increased number of applications of cellulosic materials in many sectors, including the food industry, cosmetics, and pharmaceuticals. However, to date, there are few studies investigating the potential adverse effects of cellulose nanocrystals (CNC). The objective of this study was to determine long-term outcomes on the male reproductive system of mice upon repeated pharyngeal aspiration exposure to CNC. To achieve this, cauda epididymal sperm samples were analyzed for sperm concentration, motility, morphological abnormalities, and DNA damage...
2016: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/27502389/lymphatic-delivery-of-anti-hiv-drug-nanoparticles
#17
REVIEW
Yogendra Nayak, Kiran Avadhani, Srinivas Mutalik, Usha Y Nayak
BACKGROUND: HIV infection persists for a longer time in AIDS patient compared to many other viral diseases. This is mainly because the HIV resides maximally in lymphatic system mainly the lymph nodes. Most of the present anti-HIV drugs have very poor bioavailability at lymphatic tissue. Hence, pharmaceutical scientists have made many efforts to formulate anti-HIV drugs for targeting lymphatic system. The exploration of nanoparticulate drug delivery systems have been popularly investigated for lymphatic targeting and for improving therapeutic efficacy...
2016: Recent Patents on Nanotechnology
https://www.readbyqxmd.com/read/27468180/impacts-of-chemical-modification-on-the-toxicity-of-diverse-nanocellulose-materials-to-developing-zebrafish
#18
Bryan J Harper, Alicea Clendaniel, Federico Sinche, Daniel Way, Michael Hughes, Jenna Schardt, John Simonsen, Aleksandr B Stefaniak, Stacey L Harper
Cellulose is an abundant and renewable resource currently being investigated for utility in nanomaterial form for various promising applications ranging from medical and pharmaceutical uses to mechanical reinforcement and biofuels. The utility of nanocellulose and wide implementation ensures increasing exposure to humans and the environment as nanocellulose-based technologies advance. Here, we investigate how differences in aspect ratio and changes to surface chemistry, as well as synthesis methods, influence the biocompatibility of nanocellulose materials using the embryonic zebrafish...
June 2016: Cellulose
https://www.readbyqxmd.com/read/27428180/nanostructured-drugs-embedded-into-a-polymeric-matrix-vinpocetine-pvp-hybrids-investigated-by-debye-function-analysis
#19
Dritan Hasa, Carlotta Giacobbe, Beatrice Perissutti, Dario Voinovich, Mario Grassi, Antonio Cervellino, Norberto Masciocchi, Antonietta Guagliardi
Microcrystalline vinpocetine, coground with cross-linked polyvinylpyrrolidone, affords hybrids containing nanosized drug nanocrystals, the size and size distributions of which depend on milling times and drug-to-polymer weight ratios. Using an innovative approach to microstructural characterization, we analyzed wide-angle X-ray total scattering data by the Debye function analysis and demonstrated the possibility to characterize pharmaceutical solid dispersions obtaining a reliable quantitative view of the physicochemical status of the drug dispersed in an amorphous carrier...
September 6, 2016: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/27419648/biopolymer-nano-particles-and-natural-nano-carriers-for-nano-encapsulation-of-phenolic-compounds
#20
REVIEW
Afshin Faridi Esfanjani, Seid Mahdi Jafari
Phenolic compounds are major micronutrients in our diet,(1) and evidence for their role in the prevention of degenerative diseases such as cancer, inflammation and neurodegenerative diseases is emerging. The easily destruction against environment stresses and low bioavailability of phenolics are main limitations of their application. Therefore, nano-encapsulated phenolics as a fine delivery system can solve their restrictions. Polymeric nanoparticles and natural nano-carriers are one of the most effective and industrial techniques which can be used for protection and delivery of phenolics...
October 1, 2016: Colloids and Surfaces. B, Biointerfaces
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