Yuan Ding, Qianzhu Xu, Zhilan Chai, Sunyi Wu, Weixia Xu, Jun Wang, Jianfen Zhou, Zimiao Luo, Yu Liu, Cao Xie, Linwei Lu, Weiyue Lu
Challenges for glioma treatment with nanomedicines include physio-anatomical barriers (the blood-brain barrier and blood-brain tumor barrier), low drug loading capacity, and limited circulation time. Here, a red blood cell membrane-coated docetaxel drug nanocrystal (pV-RBCm-NC(DTX)), modified with pHA-VAP (pV) for all-stage targeting of glioma, was designed. The NC(DTX) core exhibited a high drug loading capacity but low in vivo stability, and the RBCm coating significantly enhanced the stability and prolonged in vivo circulation...
April 3, 2024: Journal of Controlled Release