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Pharmaceutical nanocrystals

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https://www.readbyqxmd.com/read/29773056/nanocrystals-technology-for-pharmaceutical-science
#1
Zhongyao Cheng, Yumei Lian, Zul Kamal, Xin Ma, Jianjun Chen, Xinbo Zhou, Jing Su, Mingfeng Qiu
BACKGROUND: Nanocrystals technology is a promising method for improving the dissolution rate and enhancing the bioavailability of poorly soluble drugs. In recent years, it has been developing rapidly and applied to drug research and engineering. Nanocrystal drugs can be formulated into various dosage forms. OBJECTIVE: This review mainly focused on the nanocrystals technology and its application in pharmaceutical science. Firstly, different preparation methods of nanocrystal technology and the characterization of nanocrystal drugs are briefly described...
May 17, 2018: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29766787/nanocrystal-technology-as-a-strategy-to-improve-drug-bioavailability-and-antitumor-efficacy-for-the-cancer-treatment
#2
Mingxue Fan, Sicong Geng, Yang Liu, Jing Wang, Yiting Wang, Jian Zhong, Zhiqiang Yan, Lei Yu
BACKGROUND AND OBJECTIVE: Nanocrystal technology is an effective approach which can increase the dissolution rate of poorly water-soluble drugs by raising their saturation solubility, thus improving the drug bioavailability. With the development of nanocrystals, its preparation approaches have gradually matured, which can be generally divided into Bottom-up, Top-down and Combinative technologies. METHODS: A systematic literature review in the field of nanocrystal technology for the cancer treatment was scanned and collected data was detailedly analyzed and summarized...
May 15, 2018: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29766786/nanocrystals-the-preparation-precise-control-and-application-toward-the-pharmaceutics-and-foods-industry
#3
Cao Wu, Zhou Chen, Ya Hu, Zhiyuan Rao, Wangping Wu, Zhaogang Yang
Crystallization is a significant process employed to produce a wide variety of materials in pharmaceutical and food area. The control of crystal dimension, crystallinity, and shape is very important because they will affect the subsequent filtration, drying and grinding performance as well as the physical and chemical properties of the material. This review summarizes the special features of crystallization technology and the preparation methods of nanocrystals, and discusses analytical technology which is used to control crystal quality and performance...
May 15, 2018: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29766785/pharmaceutical-strategies-for-stabilizing-drug-nanocrystals
#4
Hyerim Yang, Hyeongmin Kim, Sumin Jung, Hyeyeon Seo, Shofa Khoirun Nida, Seung-Yup Yoo, Jaehwi Lee
BACKGROUND: Nanocrystallization technologies have been widely studied in recent years, as the formulation of drug nanocrystals solves problems of poor drug solubility and bioavailability. However, drug nanocrystals in the size range of 1-1000 nm usually need to be accompanied by stabilizers, such as polymers or surfactants, to enhance their stability. Despite their simplicity, improved dissolution rate, and enhanced bioavailability, the limited stability of nanocrystal formulations has prevented further development...
May 15, 2018: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29766780/soft-biomaterial-based-nanocrystal-in-pharmaceutical
#5
Nandi Chen, Taojunfeng Su, Zhe Cheng, Feifei An
BACKGROUND AND OBJECTIVE: Bio-soft material, a class of derivatives of the natural or synthetic material, is getting more and more prevalent in biomedical researches and applications due to the advantages such as in-vivo biodegradation, good water solubility and designable targeting ability. With the presence of bio-soft materials, the drug nanocrystal can be easily generated and aggregated in a feasible process. Given the promising application of the bio-soft material in biological and chemical research, it is valuable to discuss the crucial step in designing bio-soft materials and analyze the emerging properties of bio-soft materials...
May 15, 2018: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29738786/production-of-pure-drug-nanocrystals-and-nano-co-crystals-by-confinement-methods
#6
Flavia Fontana, Patricia Figueiredo, Pei Zhang, Jouni T Hirvonen, Dongfei Liu, Helder A Santos
The use of drug nanocrystals in the drug formulation is increasing due to the large number of poorly water-soluble drug compounds synthetized and due to the advantages brought by the nanonization process. The downsizing processes are done using a top-down approach (milling and homogenization currently employed at the industrial level), while the crystallization process is performed by bottom-up techniques (e.g., antisolvent precipitation to the use of supercritical fluids or spray and freeze drying). In addition, the production of nanocrystals in confined environment can be achieved within microfluidics channels...
May 5, 2018: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/29693630/enhanced-photocatalytic-activity-of-110-faceted-tio%C3%A2-rutile-nanorods-in-the-photodegradation-of-hazardous-pharmaceuticals
#7
Tran Thi Thuong Huyen, Tran Thi Kim Chi, Nguyen Duc Dung, Hendrik Kosslick, Nguyen Quang Liem
Rutile TiO₂ with highly active facets has attracted much attention owing to its enhanced activity during the photocatalytic degradation of pollutants such as pharmaceuticals in wastewater. However, it is difficult to obtain by controlling the synthetic conditions. This paper reports a simple hydrothermal synthesis of rutile TiO₂ nanorods with highly exposed {110} facets. The obtained rutile was characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), high-resolution transmission electron microscopy (HR-TEM), and Raman spectroscopy...
April 25, 2018: Nanomaterials
https://www.readbyqxmd.com/read/29691028/cellulose-nanocrystals-from-grape-pomace-production-properties-and-cytotoxicity-assessment
#8
Caroline C S Coelho, Michele Michelin, Miguel A Cerqueira, Catarina Gonçalves, Renata V Tonon, Lorenzo M Pastrana, Otniel Freitas-Silva, António A Vicente, Lourdes M C Cabral, José A Teixeira
Cellulose nanocrystals (CNCs) were obtained from grape pomace through chemical and physical pretreatments. Bleached cellulose pulp was subjected to acid hydrolysis (AH) for 30 or 60 min and an ultrasound treatment to obtain CNCs (AH30S and AH60S ). Compositional analyses of untreated (UGP) and pretreated (PGP) grape pomace showed the effectiveness of pretreatment in removing non-cellulosic components, recovering 80.1% cellulose in PGP (compared to 19.3% of UGP). Scanning and transmission electron microscopies were used to evaluate the CNCs morphology...
July 15, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29620092/hierarchically-porous-ultra-strong-reduced-graphene-oxide-cellulose-nanocrystal-sponges-for-exceptional-adsorption-of-water-contaminants
#9
Nariman Yousefi, Kerwin K W Wong, Zeinab Hosseinidoust, Henning Osholm Sørensen, Stefan Bruns, Yi Zheng, Nathalie Tufenkji
Self-assembly of graphene oxide (GO) nanosheets into porous 3D sponges is a promising approach to exploit their capacity to adsorb contaminants while facilitating the recovery of the nanosheets from treated water. Yet, forming mechanically robust sponges with suitable adsorption properties presents a significant challenge. Ultra-strong and highly porous 3D sponges are formed using GO, vitamin C (VC), and cellulose nanocrystals (CNCs) - natural nanorods isolated from wood pulp. CNCs provide a robust scaffold for the partially reduced GO (rGO) nanosheets resulting in an exceptionally stiff nanohybrid...
April 5, 2018: Nanoscale
https://www.readbyqxmd.com/read/29608856/formulation-and-stabilization-of-concentrated-edible-oil-in-water-emulsions-based-on-electrostatic-complexes-of-a-food-grade-cationic-surfactant-ethyl-lauroyl-arginate-and-cellulose-nanocrystals
#10
Long Bai, Wenchao Xiang, Siqi Huan, Orlando J Rojas
We report on high internal phase ratio, oil-in-water Pickering emulsions that are stable against coalescence during storage. For this, viscous, edible oil (sunflower) was emulsified in the presence of naturally-derived cellulose nanocrystals (CNC) and a food-grade, bio-based cationic surfactant obtained from lauric acid and L-arginine (ethyl lauroyl arginate, LAE). The interactions between CNC and LAE were elucidated by isothermal titration calorimetry (ITC) and supplementary techniques. LAE adsorption on CNC surfaces and its effect on nanoparticle electrostatic stabilization, aggregation state, and emulsifying ability were studied and related to the properties of resultant oil-in-water emulsions...
April 2, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/29529505/release-kinetics-and-cell-viability-of-ibuprofen-nanocrystals-produced-by-melt-emulsification
#11
A R Fernandes, J Dias-Ferreira, C Cabral, M L Garcia, E B Souto
The clinical use of poorly water-soluble drugs has become a big challenge in pharmaceutical development due to the compromised bioavailability of the drugs in vivo. Nanocrystals have been proposed as a formulation strategy to improve the dissolution properties of these drugs. The benefits of using nanocrystals in drug delivery, when compared to other nanoparticles, are related to their production facilities, simple structure, and suitability for a variety of administration routes. High pressure homogenization (HPH) is the most promising production process, which can be employed at low or high temperatures...
June 1, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29458570/functional-and-modified-nanocrystals-technology-for-target-drug-delivery
#12
Juan Zhao, Yangyang Liu, Lulu Wang, Yuqi Zhou, Juan Du, Yancai Wang
In the face of a large number of insoluble drugs, the development of nanocrystals is effective in destroying the limits of poorly soluble drug applications and becoming an indispensable route of drug delivery in the pharmaceutical industry. In addition, the proposed delivery goal is to provide more convenience and benefits and the number of researchers who are developing a number of advanced technologies try to use improved nano-drugs to improve the bioavailability of drug, drug dissolution velocity and solubility...
August 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29442814/evaluation-of-functional-sio%C3%A2-nanoparticles-toxicity-by-a-3d-culture-model
#13
Pascal Pellen-Mussi, Sylvie Tricot-Doleux, Chrystelle Neaime, Nicolas Nerambourg, Francisco Cabello-Hurtado, Stéphane Cordier, Fabien Grasset, Sylvie Jeanne
CONTEXT: as a kind of non-metal oxide SiO2 NPs have been extensively used in biomedicine, pharmaceuticals and other industrial manufacturing fields, such as DNA delivery, cancer therapy… Our group had developed a method based on microemulsion process to prepare SiO2 NPs incorporating photonic or magnetic nanocrystals and luminescent nanosized inorganic metal atom clusters. However, the toxicity of nanoparticles is known to be closely related to their physico-chemical characteristics and chemical composition...
May 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29389599/recent-developments-on-the-extraction-and-application-of-ursolic-acid-a-review
#14
REVIEW
Lucía López-Hortas, Patricia Pérez-Larrán, María Jesús González-Muñoz, Elena Falqué, Herminia Domínguez
Ursolic acid (UA) is a pentacyclic triterpenoid widely found in herbs, leaves, flowers and fruits; update information on the major natural sources or agro-industrial wastes is presented. Traditional (maceration, Soxhlet and heat reflux) and modern (microwave-, ultrasound-, accelerated solvent- and supercritical fluid) extraction and purification technologies of UA, as well as some patented process, are summarized. The great interest in this bioactive compound is related to the beneficial effects in human health due to antioxidant, antimicrobial, anti-inflammatory, hepatoprotective, immunomodulatory, anti-tumor, chemopreventive, cardioprotective, antihyperlipidemic and hypoglycemic activities, and others...
January 2018: Food Research International
https://www.readbyqxmd.com/read/29355619/nanotherapeutics-in-oral-and-parenteral-drug-delivery-key-learnings-and-future-outlooks-as-we-think-small
#15
REVIEW
Puneet Tyagi, J Anand Subramony
Nanotechnology ushered the field of medicine in to a new era. Miniaturization, increased surface area, and the unique physicochemical properties in the nano dimension were explored for new applications. Pharmaceutical industry picked up the technology and early success came fast for oral drug delivery through improvement in dissolution properties of the active molecules. Many products were launched using the nanocrystal technology on the oral side. Further development of polymeric nanoparticles led to wide spread research of nanocarriers for parenteral delivery...
February 28, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29352889/cellulose-nanocrystals-cncs-with-different-crystalline-allomorph-for-oil-in-water-pickering-emulsions
#16
Xia Li, Jun Li, Jie Gong, Yishan Kuang, Lihuan Mo, Tao Song
In recent years, nanocelluloses have attracted a lot of interests as promising stabilizers for Pickering emulsion particularly in food, cosmetics and pharmaceutics industries. In this work, two cellulose nanocrystals (named CNCs-I and CNCs-II) with different crystalline allomorph were investigated as stabilizers for oil-water Pickering emulsion. CNCs were prepared by sulfuric acid hydrolysis of unmodified and mercerized microcrystalline cellulose (MCC), respectively. CNCs-I was needle-like particles (length - 200 nm, width - 16...
March 1, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29326082/pharmaceutical-nanocrystals-production-by-wet-milling-and-applications
#17
REVIEW
Maria Malamatari, Kevin M G Taylor, Stavros Malamataris, Dennis Douroumis, Kyriakos Kachrimanis
Nanocrystals are regarded as an important nanoformulation approach exhibiting advantages of increased dissolution and saturation solubility with chemical stability and low toxicity. Nanocrystals are produced in the form of nanosuspensions using top-down (e.g., wet milling or high pressure homogenization) and bottom-up methods (e.g., antisolvent precipitation). Wet milling is a scalable method applicable to drugs with different physicochemical and mechanical properties. Nanocrystalline-based formulations, either as liquid nanosuspensions or after downstream processing to solid dosage forms, have been developed as drug delivery systems for various routes of administration (i...
March 2018: Drug Discovery Today
https://www.readbyqxmd.com/read/29285948/translation-of-combination-nanodrugs-into-nanomedicines-lessons-learned-and-future-outlook
#18
Qingxin Mu, Jesse Yu, Lisa A McConnachie, John C Kraft, Yu Gao, Gaurav K Gulati, Rodney J Y Ho
The concept of nanomedicine is not new. For instance, some nanocrystals and colloidal drug molecules are marketed that improve pharmacokinetic characteristics of single-agent therapeutics. For the past two decades, the number of research publications on single-agent nanoformulations has grown exponentially. However, formulations advancing to pre-clinical and clinical evaluations that lead to therapeutic products has been limited. Chronic diseases such as cancer and HIV/AIDS require drug combinations, not single agents, for durable therapeutic responses...
June 2018: Journal of Drug Targeting
https://www.readbyqxmd.com/read/29244515/millisecond-self-assembly-of-stable-nanodispersed-drug-formulations
#19
Vikram J Pansare, Aditya Rawal, Aaron Goodwin, Ron Beyerinck, Robert K Prud'homme, Dwayne T Friesen, Michael Grass, Annie Muske-Dukes, David T Vodak
We report the development of a new spray-drying and nanoparticle assembly process (SNAP) that enables the formation of stable, yet rapidly dissolving, sub-200 nm nanocrystalline particles within a high Tg glassy matrix. SNAP expands the class of drugs that spray-dried dispersion (SDD) processing can address to encompass highly crystalline, but modestly hydrophobic, drugs that are difficult to process by conventional SDD. The process integrates rapid precipitation and spray-drying within a custom designed nozzle to produce high supersaturations and precipitation of the drug and high Tg glassy polymer...
February 5, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29216759/pharmaceutical-potential-of-quantum-dots
#20
Swati Jha, Prateek Mathur, Suman Ramteke, Narendra Kumar Jain
Quantum dots (QDs) or fluorescent nanocrystals are designed nanoparticles that are promising for several biological and bio-medical applications as well as drug delivery and simultaneous cellular imaging. QD's have exhibited promising potential primarily in receptor based targeting as a result of their distinctive physicochemical properties. Functionalized QDs (f-QDs) have been developed as effective, safe, nano-sized smart systems to deliver a wide range of bio-actives. Surface modified fluorescent carbon QDs with surface modification have attracted attention as targeting ligand to accomplish cellular targeting with enhanced specificity...
December 7, 2017: Artificial Cells, Nanomedicine, and Biotechnology
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