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https://www.readbyqxmd.com/read/28432899/serum-micrornas-related-with-chemoradiotherapy-resistance-in-advanced-stage-cervical-squamous-cell-carcinoma
#1
Ying Han, Mei Liu, Ziyi Wang, Manni Huang, Ningzhi Xu, Lingying Wu
OBJECTIVE: To investigate the serum microRNAs as biomarkers in predicting chemoradiotherapy resistance in advanced-stage cervical squamous cell carcinoma (ACSCC) patients. METHODS: Serum samples were collected from International Federation of Gynecology and Obstetrics (FIGO) stage IIB to IIIB cervical squamous cell carcinoma patients treated with platinum based Concomitant Chemoradiotherapy (CCRT) in our hospital during September 2013 to November 2015. Twenty well-matched samples (10 resistant and 10 sensitive) were chosen to screen the miRNA expression profile using serum samples pooled with microarrays...
April 19, 2017: Translational Oncology
https://www.readbyqxmd.com/read/28421376/using-the-stopbang-questionnaire-and-other-pre-test-probability-tools-to-predict-osa-in-younger-thinner-patients-referred-to-a-sleep-medicine-clinic
#2
Michael J McMahon, Karen L Sheikh, Teotimo F Andrada, Aaron B Holley
BACKGROUND: The STOPBANG questionnaire is used to predict the presence of obstructive sleep apnea (OSA). We sought to assess the performance of the STOPBANG questionnaire in younger, thinner patients referred to a sleep medicine clinic. METHODS: We applied the STOPBANG questionnaire to patients referred for level I polysomnography (PSG) at our sleep center. We calculated likelihood ratios and area under the receiver operator characteristic (AUROC) curve and performed sensitivity analyses...
April 19, 2017: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/28419005/clinical-utility-of-polymerase-chain-reaction-testing-for-streptococcus-pneumoniae-in-pediatric-cerebrospinal-fluid-samples-a-diagnostic-accuracy-study-of-more-than-2000-samples-from-2004-2015
#3
Abdullah Alqayoudhi, Maryke Nielsen, Nicola O'Sullivan, Mary Corcoran, Patrick J Gavin, Karina M Butler, Robert Cunney, Richard J Drew
The aim of this retrospective study was to review the diagnostic accuracy of real-time polymerase chain reaction (PCR) testing of cerebrospinal fluid (CSF) samples for Streptococcus pneumoniae DNA in comparison with traditional bacterial culture. The hypothesis was that PCR is more sensitive than culture and would detect more cases of pneumococcal meningitis, particularly in children treated with antimicrobials before CSF sampling occurred. Patients younger than 16 years who had a CSF sample tested for S.pneumoniae DNA by PCR between 2004 and 2015 were included...
April 17, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28412430/incremental-prognostic-value-of-stress-echocardiography-with-carotid-ultrasound-for-suspected-cad
#4
Shahram Ahmadvazir, Benoy N Shah, Konstantinos Zacharias, Roxy Senior
OBJECTIVES: This study hypothesized that ischemia and atherosclerosis assessment by ultrasound (US) may provide incremental prognostic information in patients with new-onset chest pain who do not have coronary artery disease (CAD). BACKGROUND: The clinical significance of atherosclerosis assessment by carotid US in patients undergoing stress echocardiography (SE) in such patients is unknown. METHODS: Consecutive patients with suspected angina but no history of CAD underwent simultaneous SE and US prospectively to assess myocardial ischemia and carotid plaque burden (CPB), respectively...
April 7, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28411522/breaking-the-age-barrier-epilepsy-surgery-in-septuagenarians
#5
Vineet Punia, Ahmed Abdelkader, Andrey Stojic
Resective epilepsy surgery (RES) has traditionally been offered to young patients (<50years). The reservation about offering RES to the elderly is multifactorial with their advanced age and comorbidities being the primary reason. The elderly age group (≥65years of age) is one of the fastest growing populations. The arbitrary age limits for RES need reconsideration in the face of an ever increasing elderly population. Considering such changes in demographics, we report the first case series in the literature of seven septuagenarians who underwent RES in the form of anterior temporal lobectomy (ATL)...
April 12, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28408776/application-of-direct-polymerase-chain-reaction-assays-for-campylobacter-fetus-subsp-venerealis-and-tritrichomonas-foetus-to-screen-preputial-samples-from-breeding-bulls-in-cow-calf-herds-in-western-canada
#6
Cheryl L Waldner, Sarah Parker, Karen M Gesy, Taryn Waugh, Emily Lanigan, John R Campbell
The primary objectives of this study were to estimate the prevalence of Campylobacter fetus subsp. venerealis (Cfv) and Tritrichomonas foetus in breeding bulls from a sentinel cohort of cow-calf herds in western Canada and to estimate the association between positive test status and non-pregnancy. The final objective was to evaluate the application of these tests when: i) screening bulls in the absence of a recognized problem with reproductive performance, and ii) testing for diagnosis of poor pregnancy rates...
April 2017: Canadian Journal of Veterinary Research, Revue Canadienne de Recherche Vétérinaire
https://www.readbyqxmd.com/read/28402059/molecular-markers-of-putative-spermatogonial-stem-cells-in-the-domestic-cat
#7
S J Bedford-Guaus, S Kim, L Mulero, J M Vaquero, C Morera, R Adan-Milanès, A Veiga, Á Raya
Spermatogonial stem cells (SSCs) are an important tool for fertility preservation and species conservation. The ability to expand SSCs by in vitro culture is a crucial premise for their use in assisted reproduction. Because SSCs represent a small proportion of the germ cells in the adult testis, culture success is aided by pre-enrichment through sorting techniques based on cell surface-specific markers. Given the importance of the domestic cat as a model for conservation of endangered wild felids, herein we sought to examine culture conditions as well as molecular markers for cat SSCs...
April 2017: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/28400550/primary-pituitary-tuberculosis-revisited
#8
Fatma Ben Abid, Mohammed Abukhattab, Hanfa Karim, Mohamed Agab, Issam Al-Bozom, Wanis H Ibrahim
BACKGROUND Primary pituitary tuberculosis (in absence of other organ involvement and constitutional symptoms) is an extremely rare disease with total reported cases in the literature fewer than a hundred. Misdiagnosis as pituitary adenoma is common and late diagnosis can result in a permanent endocrine dysfunction and/or long-term neurologic sequelae. CASE REPORT We report on the case of a middle-aged woman who presented with severe headache and left third cranial nerve palsy. Magnetic resonance imaging (MRI) revealed a large pituitary tumor invading the left cavernous sinus...
April 12, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/28391124/performance-characteristics-of-an-automated-latex-immunoturbidimetric-assay-hemosil-%C3%A2-hit-ab-pf4-h-for-the-diagnosis-of-immune-heparin-induced-thrombocytopenia
#9
Theodore E Warkentin, Jo-Ann I Sheppard, Lori-Ann Linkins, Donald M Arnold, Ishac Nazy
BACKGROUND: Heparin-induced thrombocytopenia (HIT) is a prothrombotic drug reaction caused by platelet-activating anti-PF4/heparin antibodies. Given time-sensitive treatment considerations, a rapid and accurate laboratory test for HIT antibodies is needed. AIMS: To determine operating characteristics for the HemosIL(®) HIT-Ab(PF4/H), a rapid, on-demand, fully-automated, latex immunoturbidimetric assay (LIA), for diagnosis of HIT. METHODS: We evaluated LIA sensitivity, specificity, negative (NPV) and positive predictive value (PPV), negative (LR-) and positive likelihood ratio (LR+), using citrated-plasma from 429 patients (prospective cohort study of 4Ts scoring; HIT, n=31), and from consecutive HIT patients (n=125), using reference standard serotonin-release assay (SRA)...
March 11, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28390331/body-image-construct-of-sri-lankan-adolescents
#10
B L Goonapienuwala, S B Agampodi, N S Kalupahana, S Siribaddana
Introduction: “Body image” is more than the visual perception of size and it is probably multidimensional. It is known to influence eating behaviors and self-esteem of adolescents. Although widely studied in developed countries, it has been studied little in Sri Lanka. Objectives: This study was designed to translate and culturally adapt a tool to assess dimensions of body image in Sri Lankan adolescents. Methods: The study was carried out in the Anuradhapura District on school going children in grades nine to eleven...
March 31, 2017: Ceylon Medical Journal
https://www.readbyqxmd.com/read/28389572/prognostic-value-of-noninvasive-cardiovascular-testing-in-patients-with-stable-chest-pain-insights-from-the-promise-trial
#11
Udo Hoffmann, Maros Ferencik, James E Udelson, Michael H Picard, Quynh A Truong, Manesh R Patel, Megan Huang, Michael J Pencina, Daniel B Mark, John F Heitner, Christopher B Fordyce, Patricia A Pellikka, Jean-Claude Tardif, Matthew J Budoff, George Nahhas, Benjamin J Chow, Andrzej S Kosinski, Kerry L Lee, Pamela S Douglas
Background -Optimal management of patients with stable chest pain relies on the prognostic information provided by noninvasive cardiovascular testing, but there are limited data from randomized trials comparing anatomic with functional testing. Methods -In the Prospective Multicenter Imaging Study for Evaluation of Chest Pain (PROMISE) trial, patients with stable chest pain and intermediate pre-test probability for obstructive coronary artery disease (CAD) were randomized to functional testing (exercise electrocardiography, nuclear stress, or stress echocardiography) or coronary computed tomography angiography (CTA)...
April 7, 2017: Circulation
https://www.readbyqxmd.com/read/28389027/role-of-pet-ct-with-18-f-fluorocholine-in-biochemical-recurrence-after-treatment-of-prostate-cancer-with-curative-intent
#12
I Puche-Sanz, E Triviño-Ibáñez, F Vázquez-Alonso, J M Llamas-Elvira, J M Cózar-Olmo, A Rodríguez-Fernández
OBJECTIVES: To analyse the ability of the PET-CT with (18)F-fluorocholine ((18)F-FCH) to detect disease on biochemical recurrence after treatment with curative intent. To determine the clinical variables that would be able to optimise the test's diagnostic yield. MATERIAL AND METHODS: A retrospective study of PET-CTs with (18)F-fluorocholine performed on 61 patients with prostate cancer who had undergone treatment with curative intent and met the criteria for biochemical recurrence...
April 4, 2017: Actas Urologicas Españolas
https://www.readbyqxmd.com/read/28386958/amylase-in-drain-fluid-for-the-diagnosis-of-pancreatic-leak-in-post-pancreatic-resection
#13
REVIEW
Tsetsegdemberel Bat-Ulzii Davidson, Mohammad Yaghoobi, Brian R Davidson, Kurinchi Selvan Gurusamy
BACKGROUND: The treatment of people with clinically significant postoperative pancreatic leaks is different from those without clinically significant pancreatic leaks. It is important to know the diagnostic accuracy of drain fluid amylase as a triage test for the detection of clinically significant pancreatic leaks, so that an informed decision can be made as to whether the patient with a suspected pancreatic leak needs further investigations and treatment. There is currently no systematic review of the diagnostic test accuracy of drain fluid amylase for the diagnosis of clinically relevant pancreatic leak...
April 7, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28377702/brain-acetaldehyde-exposure-impacts-upon-neonatal-respiratory-plasticity-and-ethanol-related-learning-in-rodents
#14
María B Acevedo, Génesis D'Aloisio, Olga B Haymal, Juan C Molina
Prior studies indicate that neonates are very sensitive to ethanol's positive reinforcing effects and to its depressant effects upon breathing. Acetaldehyde (ACD) appears to play a major role in terms of modulating early reinforcing effects of the drug. Yet, there is no pre-existing literature relative to the incidence of this metabolite upon respiratory plasticity. The present study analyzed physiological and behavioral effects of early central administrations of ethanol, acetaldehyde or vehicle. Respiration rates (breaths/min) were registered at post-natal days (PDs) 2 and 4 (post-administration time: 5, 60, or 120 min)...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/28370759/d-dimer-interval-likelihood-ratios-for-pulmonary-embolism
#15
Michael A Kohn, Frederikus A Klok, Nick van Es
OBJECTIVE: To estimate D-Dimer interval likelihood ratios (iLRs) for diagnosing pulmonary embolism (PE). METHODS: The authors used pooled patient-level data from five PE diagnostic management studies to estimate iLRs for the eight D-Dimer intervals with boundaries 250, 500, 750, 1000, 1500, 2500, and 5000 ng/mL. Logistic regression was used to fit the data so that an interval increase corresponds to increasing the likelihood ratio by a constant factor. RESULTS: The iLR for the D-Dimer interval 1000-1499 ng/mL was essentially 1...
April 1, 2017: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/28369259/diagnostic-value-of-global-myocardial-perfusion-reserve-assessment-based-on-coronary-sinus-flow-measurements-using-cardiovascular-magnetic-resonance-in-addition-to-myocardial-stress-perfusion-imaging
#16
Zornitsa Shomanova, Anca Florian, Michael Bietenbeck, Johannes Waltenberger, Udo Sechtem, Ali Yilmaz
Aims: Myocardial perfusion reserve (MPR) is defined as the maximal possible increase in myocardial blood flow (MBF) above baseline conditions. Global MBF can be measured non-invasively by means of coronary sinus flow velocity encoded cine (VENC) cardiovascular magnetic resonance (CMR). We aimed to explore the relationship between global MBF/MPR and the extent and severity of coronary artery disease (CAD) in patients referred for CAD work-up by adenosine-stress CMR. Methods and results: Fifty-eight patients with suspected obstructive CAD underwent both adenosine-stress CMR and invasive coronary angiography...
March 23, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/28366287/whole-body-computed-tomography-versus-selective-radiological-imaging-strategy-in-trauma-an-evidence-based-clinical-review
#17
Brit Long, Michael D April, Shane Summers, Alex Koyfman
BACKGROUND: Trauma patients often present with injuries requiring resuscitation and further evaluation. Many providers advocate for whole body computed tomography (WBCT) for rapid and comprehensive diagnosis of life-threatening injuries. OBJECTIVE: Evaluate the literature concerning mortality effect, emergency department (ED) length of stay, radiation, and incidental findings associated with WBCT. DISCUSSION: Physicians have historically relied upon history and physical examination to diagnose life-threatening injuries in trauma...
March 21, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28358277/evaluation-of-head-and-brain-injury-risk-functions-using-sub-injurious-human-volunteer-data
#18
Erin J Sanchez, Lee F Gabler, James S McGhee, Ardyn V Olszko, Valeta Carol Chancey, Jeff Crandall, Matthew B Panzer
Risk assessment models are developed to estimate the probability of brain injury during head impact using mechanical response variables such as head kinematics and brain tissue deformation. Existing injury risk functions have been developed using different datasets based on human volunteer and scaled animal injury responses to impact. However, many of these functions have not been independently evaluated with respect to laboratory-controlled human response data. In this study, the specificity of fourteen existing brain injury risk functions was assessed by evaluating their ability to correctly predict non-injurious response using previously conducted sled tests with well-instrumented human research volunteers...
March 30, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28357778/impact-of-panel-gene-testing-for-hereditary-breast-and-ovarian-cancer-on-patients
#19
Heidi S Lumish, Hallie Steinfeld, Carrie Koval, Donna Russo, Elana Levinson, Julia Wynn, James Duong, Wendy K Chung
Recent advances in next generation sequencing have enabled panel gene testing, or simultaneous testing for mutations in multiple genes for a clinical condition. With more extensive and widespread genetic testing, there will be increased detection of genes with moderate penetrance without established clinical guidelines and of variants of uncertain significance (VUS), or genetic variants unknown to either be disease-causing or benign. This study surveyed 232 patients who underwent genetic counseling for hereditary breast and ovarian cancer to examine the impact of panel gene testing on psychological outcomes, patient understanding, and utilization of genetic information...
March 29, 2017: Journal of Genetic Counseling
https://www.readbyqxmd.com/read/28357464/monosodium-glutamate-associated-alterations-in-open-field-anxiety-related-and-conditioned-place-preference-behaviours-in-mice
#20
Olakunle James Onaolapo, Olaleye Samuel Aremu, Adejoke Yetunde Onaolapo
The present study investigated changes in behaviour associated with oral monosodium glutamate (a flavouring agent), using the open field, elevated plus maze and conditioned place preference (CPP) paradigms, respectively. Mice were assigned to two groups for CPP [monosodium glutamate (MSG)-naïve (n = 40) and MSG-pretreated (n = 40)] and two groups for open field (OF) and elevated plus maze (EPM) tests [n = 40 each], respectively. Animals in respective groups were then divided into four subgroups (n = 10) (vehicle or MSG (80, 160 and 320 mg/kg))...
March 29, 2017: Naunyn-Schmiedeberg's Archives of Pharmacology
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