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https://www.readbyqxmd.com/read/28710583/prototype-metal-artefact-reduction-algorithm-in-flat-panel-computed-tomography-evaluation-in-patients-undergoing-transarterial-hepatic-radioembolisation
#1
Qeumars Mustafa Hamie, Adrian Raoul Kobe, Leif Mietzsch, Michael Manhart, Gilbert Dominique Puippe, Thomas Pfammatter, Roman Guggenberger
OBJECTIVE: To investigate the effect of an on-site prototype metal artefact reduction (MAR) algorithm in cone-beam CT-catheter-arteriography (CBCT-CA) in patients undergoing transarterial radioembolisation (RE) of hepatic masses. METHODS AND MATERIALS: Ethical board approved retrospective study of 29 patients (mean 63.7±13.7 years, 11 female), including 16 patients with arterial metallic coils, undergoing CBCT-CA (8s scan, 200 degrees rotation, 397 projections)...
July 14, 2017: European Radiology
https://www.readbyqxmd.com/read/28685382/safety-and-efficacy-of-transarterial-radioembolisation-in-patients-with-intermediate-or-advanced-stage-hepatocellular-carcinoma-refractory-to-chemoembolisation
#2
Elisabeth G Klompenhouwer, Raphaëla C Dresen, Chris Verslype, Annouschka Laenen, Gert De Hertogh, Christophe M Deroose, Lawrence Bonne, Vincent Vandevaveye, Geert Maleux
INTRODUCTION: Transarterial chemoembolisation (TACE) is the most widely used locoregional treatment for patients with an unresectable hepatocellular carcinoma (HCC). Transarterial radioembolisation (TARE) with yttrium-90 containing microspheres is an emerging interventional treatment that could be complementary or an alternative to TACE. AIM: To evaluate the safety and efficacy of TARE in patients with HCC who are refractory to TACE with drug-eluting beads (DEB-TACE)...
July 6, 2017: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/28677067/intra-arterial-therapy-of-neuroendocrine-tumour-liver-metastases-comparing-conventional-tace-drug-eluting-beads-tace-and-yttrium-90-radioembolisation-as-treatment-options-using-a-propensity-score-analysis-model
#3
Duc Do Minh, Julius Chapiro, Boris Gorodetski, Qiang Huang, Cuihong Liu, Susanne Smolka, Lynn Jeanette Savic, David Wainstejn, MingDe Lin, Todd Schlachter, Bernhard Gebauer, Jean-François Geschwind
OBJECTIVES: To compare efficacy, survival outcome and prognostic factors of conventional transarterial chemoembolisation (cTACE), drug-eluting beads TACE (DEB-TACE) and yttrium-90 radioembolisation (Y90) for the treatment of liver metastases from gastroenteropancreatic (GEP) neuroendocrine tumours (NELM). METHODS: This retrospective analysis included 192 patients (58.6 years mean age, 56% men) with NELM treated with cTACE (N = 122), DEB-TACE (N = 26) or Y90 (N = 44) between 2000 and 2014...
July 4, 2017: European Radiology
https://www.readbyqxmd.com/read/28674968/recommendations-for-radioembolisation-after-liver-surgery-using-yttrium-90-resin-microspheres-based-on-a-survey-of-an-international-expert-panel
#4
Morsal Samim, Linde M van Veenendaal, Manon N G J A Braat, Andor F van den Hoven, Richard Van Hillegersberg, Bruno Sangro, Yung Hsiang Kao, Dave Liu, John D Louie, Daniel Y Sze, Steven C Rose, Daniel B Brown, Hojjat Ahmadzadehfar, Edward Kim, Maurice A A J van den Bosch, Marnix G E H Lam
INTRODUCTION: Guidelines on how to adjust activity in patients with a history of liver surgery who are undergoing yttrium-90 radioembolisation ((90)Y-RE) are lacking. The aim was to study the variability in activity prescription in these patients, between centres with extensive experience using resin microspheres (90)Y-RE, and to draw recommendations on activity prescription based on an expert consensus. METHODS: The variability in activity prescription between centres was investigated by a survey of international experts in the field of (90)Y-RE...
July 3, 2017: European Radiology
https://www.readbyqxmd.com/read/28656502/update-on-treatment-options-for-advanced-bile-duct-tumours-radioembolisation-for-advanced-cholangiocarcinoma
#5
REVIEW
Pavan Najran, Angela Lamarca, Damian Mullan, Mairéad G McNamara, Thomas Westwood, Richard A Hubner, Jeremy Lawrence, Prakash Manoharan, Jon Bell, Juan W Valle
Cholangiocarcinoma is a rare form of gastrointestinal cancer with a poor prognosis. Patients often present with biliary obstruction or non-specific abdominal pain, and a high proportion of patients have advanced disease at initial diagnosis. The goal of this review is to discuss treatment options for patients with advanced bile duct tumours focusing on radioembolisation (RE) and its impact on overall survival. RE provides a therapeutic option for patients with unresectable cholangiocarcinoma. However, although systemic chemotherapy has demonstrated a survival benefit in randomised controlled trials, there is limited supporting evidence for the use of RE in this setting...
July 2017: Current Oncology Reports
https://www.readbyqxmd.com/read/28634669/yttrium-90-y-90-resin-microsphere-therapy-for-patients-with-unresectable-hepatocellular-carcinoma-a-single-center-experience
#6
Semra İnce, Bülent Karaman, Engin Alagoz, Nuri Karadurmuş, Hüseyin Şan, Cemal Nuri Erçin, Nuri Arslan
BACKGROUND/AIM: Selective intraarterial radionuclide therapy (SIRT) with yttrium-90 (Y-90) resin microspheres presently has successful results in primary or metastatic inoperable liver tumors. This procedure, which is also known as radioembolisation, delivers high doses of radiation selectively to hepatic tumors while minimum healthy liver exposure. The aim of this study was to present our clinical experience of radiomicrosphere therapy for the treatment of patients with unresectable hepatocellular carcinoma (HCC)...
June 20, 2017: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/28536968/clinical-and-imaging-based-prognostic-factors-in-radioembolisation-of-liver-metastases-from-colorectal-cancer-a-retrospective-exploratory-analysis
#7
Kathy P Willowson, Aimee R Hayes, David L H Chan, Michael Tapner, Elizabeth J Bernard, Richard Maher, Nick Pavlakis, Stephen J Clarke, Dale L Bailey
BACKGROUND: The aim of this study was to investigate the relationship between absorbed dose and response of colorectal cancer liver metastases treated with [(90)Y]-resin microspheres and to explore possible clinical and imaging derived prognostic factors. METHODS: FDG PET/CT was used to measure response of individual lesions to a measured absorbed dose, derived from post-treatment (90)Y PET imaging. Predicted dose was also derived from planning [(99m)Tc]-MAA SPECT data...
December 2017: EJNMMI Research
https://www.readbyqxmd.com/read/28407278/prevention-and-treatment-of-complications-of-selective-internal-radiation-therapy-expert-guidance-and-systematic-review
#8
REVIEW
Bruno Sangro, Diego Martínez-Urbistondo, Lourens Bester, Jose I Bilbao, Douglas M Coldwell, Patrick Flamen, Andrew Kennedy, Jens Ricke, Ricky A Sharma
Selective internal radiation therapy (SIRT or radioembolisation) by intraarterial injection of radioactive yttrium-90 ((90) Y)-loaded microspheres is increasingly used for the treatment of patients with liver metastases or primary liver cancer. The high-dose beta-radiation penetrates an average of only 2.5 mm from the source so that its effects are limited to the site of delivery. However the off-target diversion of (90) Y microspheres to tissues other than the tumor may lead to complications. The most prominent ones include: radiation gastritis and gastrointestinal (GI) ulcers, cholecystitis, radiation pneumonitis, and radioembolisation-induced liver disease (REILD)...
April 13, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28202430/vespro-an-individual-patient-data-prospective-meta-analysis-of-selective-internal-radiation-therapy-versus-sorafenib-for-advanced-locally-advanced-or-recurrent-hepatocellular-carcinoma-of-the-sarah-and-sirvenib-trials
#9
Val Gebski, Emma Gibbs, Mihir Gandhi, Gilles Chatellier, Aurelia Dinut, Helena Pereira, Pierce Kh Chow, Valérie Vilgrain
BACKGROUND: Untreated advanced hepatocellular carcinoma (HCC) has an overall poor prognosis. Currently there are 2 ongoing prospective randomized controlled trials that are evaluating the efficacy and safety of sorafenib and selective internal radiation therapy (SIRT) with yttrium-90 resin microspheres in patients with advanced HCC. The SorAfenib versus Radioembolisation in Advanced Hepatocellular carcinoma (SARAH; 459 patients) trial is being performed in Europe and the SIRt VErsus SorafeNIB (SIRveNIB; 360 patients) trial in the Asia Pacific region...
February 15, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/27993095/personnel-dose-reduction-in-90-y-microspheres-liver-directed-radioembolization-from-interventional-radiology-suite-to-patient-ward
#10
Martin Law, K K Wong, W K Tso, Victor Lee, M Y Luk, C C Tong, Ferdinand Chu
OBJECTIVE: To describe a method to reduce the external radiation exposure emitted from the patient after liver-directed radioembolization using (90)Y glass microspheres, to quantitatively estimate the occupational dose of medical personnel providing patient care to the patient radioembolized with the use of the method and to discuss radiation exposure to patients who are adjacent if the patient radioembolized needs hospitalization. METHODS: A lead-lined blanket of lead equivalence of 0...
March 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/27622200/treatment-response-after-radioembolisation-in-patients-with-hepatocellular-carcinoma-an-evaluation-with-dual-energy-computed-tomography
#11
Jens Altenbernd, Axel Wetter, Michael Forsting, Lale Umutlu
PURPOSE: The aim of this prospective study was to examine the diagnostic value of dual-energy CT (DECT) in the assessment of response of HCC after radioembolisation (RE). MATERIAL AND METHODS: 40 HCC patients with 82 measurable target lesions were included in this study. At baseline and follow-up examination target lesions were evaluated with (IU), AASLD and Choi measurement criteria. Disease control was defined as the sum of complete response (CR), partial response (PR), progression disease (PD) and stable disease (SD)...
2016: European Journal of Radiology Open
https://www.readbyqxmd.com/read/27307346/partition-model-based-99mtc-maa-spect-ct-predictive-dosimetry-compared-with-90y-tof-pet-ct-posttreatment-dosimetry-in-radioembolization-of-hepatocellular-carcinoma-a-quantitative-agreement-comparison
#12
COMPARATIVE STUDY
Silvano Gnesin, Laurent Canetti, Salim Adib, Nicolas Cherbuin, Marina Silva Monteiro, Pierre Bize, Alban Denys, John O Prior, Sebastien Baechler, Ariane Boubaker
(90)Y-microsphere selective internal radiation therapy (SIRT) is a valuable treatment in unresectable hepatocellular carcinoma (HCC). Partition-model predictive dosimetry relies on differential tumor-to-nontumor perfusion evaluated on pretreatment (99m)Tc-macroaggregated albumin (MAA) SPECT/CT. The aim of this study was to evaluate agreement between the predictive dosimetry of (99m)Tc-MAA SPECT/CT and posttreatment dosimetry based on (90)Y time-of-flight (TOF) PET/CT. METHODS: We compared the (99m)Tc-MAA SPECT/CT results for 27 treatment sessions (25 HCC patients, 41 tumors) with (90)Y SIRT (7 glass spheres, 20 resin spheres) and the posttreatment (90)Y TOF PET/CT results...
November 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/27108297/liver-ct-for-vascular-mapping-during-radioembolisation-workup-comparison-of-an-early-and-late-arterial-phase-protocol
#13
COMPARATIVE STUDY
Andor F van den Hoven, Manon N G J A Braat, Jip F Prince, Pieter J van Doormaal, Maarten S van Leeuwen, Marnix G E H Lam, Maurice A A J van den Bosch
OBJECTIVES: To compare right gastric (RGA) and segment 4 artery (A4) origin detection rates during radioembolisation workup between early and late arterial phase liver CT protocols. METHODS: 100 consecutive patients who underwent liver CT between May 2012-January 2015 with early or late arterial phase protocol (n = 50 each, 10- vs. 20-s post-threshold delay) were included. RGA/A4 origin detection rates, assessed by two raters, and contrast-to-noise ratio (CNR) of the hepatic artery relative to the portal vein were compared between the protocols...
January 2017: European Radiology
https://www.readbyqxmd.com/read/27020341/origin-dosimetric-effect-and-clinical-limitations-of-the-semi-empirical-body-surface-area-method-for-radioembolisation-using-yttrium-90-resin-microspheres
#14
Yung Hsiang Kao, Meir Lichtenstein
No abstract text is available yet for this article.
June 2016: Journal of Medical Imaging and Radiation Oncology
https://www.readbyqxmd.com/read/26905230/yttrium-90-microsphere-radioembolisation-for-unresectable-hepatocellular-carcinoma
#15
REVIEW
Omar M Abdel-Rahman, Zeinab Elsayed
BACKGROUND: Hepatocellular carcinoma is the most common liver neoplasm and the fifth most common cancer worldwide. Moreover, its incidence has increased dramatically since the mid-2000s. While surgical resection and liver transplantation are the main curative treatments, only around 20% of people with early hepatocellular carcinoma may benefit from these therapies. Current treatment options for unresectable hepatocellular carcinoma include various ablative and trans-arterial therapies in addition to the drug sorafenib...
2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/26638448/-about-juvenile-nasopharyngeal-angiofibroma
#16
V Urbain, P Meunier, B Otto
We report the case of a young man with a juvenile nasopharyngeal angiofibroma. In this paper, we will first remind the clinical signs of this pathology and its radiological appearance (localisation and extensions). Then we will explain how radioembolisation techniques were used to facilitate the surgical intervention. Finally we will discuss the histology of this tumor.
September 2015: Revue Médicale de Liège
https://www.readbyqxmd.com/read/26516379/sorafenib-for-the-treatment-of-hepatocellular-carcinoma-with-portal-vein-tumour-thrombosis-a-systematic-review-of-comparative-studies
#17
REVIEW
Xingshun Qi, Xiaozhong Guo
Sorafenib is the first-line treatment of choice for advanced hepatocellular carcinoma (HCC). However, the benefits of sorafenib in HCC patients with portal vein tumour thrombosis (PVTT) remain uncertain. Until now, a total of eight comparative studies have been identified for this systematic review. Four retrospective studies showed that hepatic arterial infusion chemotherapy, hepatic resection, and three-dimensional conformal radiotherapy might be superior to sorafenib in improving the overall survival. Two ongoing randomised controlled trials (RCTs) will compare the outcomes of transarterial chemoembolisation or radioembolisation with those of sorafenib for the treatment of HCC with PVTT...
2015: Przegla̜d Gastroenterologiczny
https://www.readbyqxmd.com/read/26327775/radioembolisation-and-portal-vein-embolization-before-resection-of-large-hepatocellular-carcinoma
#18
Fikri Bouazza, Arthur Poncelet, Camilo Alejandro Garcia, Philippe Delatte, Jean Luc Engelhom, Maria Gomez Galdon, Amélie Deleporte, Alain Hendlisz, Bruno Vanderlinden, Patrick Flamen, Vincent Donckier
Resectability of hepatocellular carcinoma in patients with chronic liver disease is dramatically limited by the need to preserve sufficient remnant liver in order to avoid postoperative liver insufficiency. Preoperative treatments aimed at downsizing the tumor and promoting hypertrophy of the future remnant liver may improve resectability and reduce operative morbidity. Here we report the case of a patient with a large hepatocellular carcinoma arising from chronic liver disease. Preoperative treatment, including tumor downsizing with transarterial radioembolization and induction of future remnant liver hypertrophy with right portal vein embolization, resulted in a 53% reduction in tumor volume and compensatory hypertrophy in the contralateral liver...
August 28, 2015: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/26238772/scientific-basis-of-personalised-tomographic-radiation-planning-for-radioembolisation-a-form-of-brachytherapy-planning
#19
Yung Hsiang Kao, Mark Goodwin, Sze Ting Lee, Meir Lichtenstein, Andrew Mark Scott
Today's tomographic imaging techniques such as catheter-directed CT and single photon emission computed tomography with integrated computed tomography may be used for pre-therapy radiation planning for radioembolisation based on prospective calculation of tissue radiation absorbed doses. We outline the scientific concepts that underlie modern personalised tomographic radiation planning for radioembolisation and highlight its similarities to brachytherapy planning.
October 2015: Journal of Medical Imaging and Radiation Oncology
https://www.readbyqxmd.com/read/26116112/heterogeneity-of-microsphere-distribution-in-resected-liver-and-tumour-tissue-following-selective-intrahepatic-radiotherapy
#20
Jonas Högberg, Magnus Rizell, Ragnar Hultborn, Johanna Svensson, Olof Henrikson, Johan Mölne, Peter Gjertsson, Peter Bernhardt
BACKGROUND: Selective arterial radioembolisation of liver tumours has increased, because of encouraging efficacy reports; however, therapeutic parameters used in external beam therapy are not applicable for understanding and predicting potential toxicity and efficacy, necessitating further studies of the physical and biological characteristics of radioembolisation. The aim was to characterise heterogeneity in the distribution of microspheres on a therapeutically relevant geometric scale considering the range of yttrium-90 ((90)Y) β-particles...
December 2014: EJNMMI Research
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