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https://www.readbyqxmd.com/read/28821319/higher-dietary-acid-load-is-weakly-associated-with-higher-adiposity-measures-and-blood-pressure-in-japanese-adults-the-national-health-and-nutrition-survey
#1
Kentaro Murakami, M Barbara E Livingstone, Hitomi Okubo, Satoshi Sasaki
Epidemiologic evidence on the associations between dietary acid load and metabolic risk factors are limited and inconsistent. We investigated the hypothesis that dietary acid load is associated with adverse profiles of metabolic risk factors in Japanese adults. This cross-sectional study included 15 618 Japanese adults aged ≥20 years from the 2012 National Health and Nutrition Survey, Japan. Dietary acid load was characterized as potential renal acid load (PRAL) and net endogenous acid production (NEAP) based on information on nutrient intake, which was derived from a 1-day semi-weighed dietary record...
August 2017: Nutrition Research
https://www.readbyqxmd.com/read/28819072/-overview-of-hereditary-spinocerebellar-ataxias-in-japan
#2
Masayoshi Tada, Akio Yokoseki, Osamu Onodera
Hereditary spinocerebellar degenerations (SCD) are a group of neurodegenerative disorders characterized by slowly progressive ataxia associated with non-cerebellar neurological signs and symptoms. In the Japanese population, dominantly inherited SCDs are much more common than recessively inherited or X-linked SCDs. The most common dominantly inherited SCD in Japan, as well as in many other countries, is Machado-Joseph disease, also known as spinocerebellar ataxia type 3 (MJD/SCA3). MJD/SCA3 is frequently accompanied by non-cerebellar symptoms, including progressive external ophthalmoplegia, pyramidal signs, dystonia, rigidity, dysarthria, and distal muscle atrophies...
August 2017: Brain and Nerve, Shinkei Kenkyū No Shinpo
https://www.readbyqxmd.com/read/28818549/integration-of-dpc-and-clinical-microbiological-data-in-japan-reveals-importance-of-confirming-a-negative-follow-up-blood-culture-in-patients-with-mrsa-bacteremia
#3
Naoki Miyamoto, Koji Yahara, Rie Horita, Tomomi Yano, Naotaka Tashiro, Daiichi Morii, Atsuko Tsutsui, Kenichiro Yaita, Keigo Shibayama, Hiroshi Watanabe
Methicillin-resistant Staphylococcus aureus (MRSA) bacteremia is one of the commonest and most life-threatening of all infectious diseases. The morbidity and mortality rates associated with MRSA bacteremia are higher than those associated with bacteremia caused by other pathogens. A common guideline in MRSA bacteremia treatment is to confirm bacteremia clearance through additional blood cultures 2-4 days after initial positive cultures and as needed thereafter. However, no study has presented statistical evidence of how and to what extent confirming a negative follow-up blood culture impacts clinical outcome...
August 14, 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/28817940/-confirming-the-utility-of-raisus-antifungal-susceptibility-testing-by-new-software
#4
Tomoko Ono, Hiroyuki Suematsu, Haruki Sawamura, Yuka Yamagishi, Hiroshige Mikamo
Clinical and Laboratory Standards Institute (CLSI) methods for susceptibility tests of yeast are used in Japan. On the other hand, the methods have some disadvantage; 1) reading at 24 and 48 h, 2) using unclear scale, approximately 50% inhibition, to determine MICs, 3) calculating trailing growth and paradoxical effects. These makes it difficult to test the susuceptibility for yeasts. Old software of RAISUS, Ver. 6.0 series, resolved problem 1) and 2) but did not resolve problem 3). Recently, new software of RAISUS, Ver...
August 15, 2017: JARMAM: Journal of the Association for Rapid Method and Automation in Microbiology
https://www.readbyqxmd.com/read/28817628/effectiveness-of-helicobacter-pylori-eradication-in-the-prevention-of-primary-gastric-cancer-in-healthy-asymptomatic-people-a-systematic-review-and-meta-analysis-comparing-risk-ratio-with-risk-difference
#5
Takeshi Seta, Yoshimitsu Takahashi, Yoshinori Noguchi, Satoru Shikata, Tatsuya Sakai, Kyoko Sakai, Yukitaka Yamashita, Takeo Nakayama
BACKGROUND: Helicobacter pylori infection is strongly associated with gastric cancer occurrence. However, it is unclear whether eradication therapy reduces the risk of gastric cancer occurrence. We evaluated whether H. pylori eradication reduces the risk of primary gastric cancer by using both risk ratio (RR) and risk difference (RD). METHODS: Searches of PubMed, EMBASE, Google scholar, the Cochrane Library, and the Japan Medical Abstracts Society as well as those registered in databases of the Cochrane Central Register of Controlled Trials, metaRegister of Controlled Trials, ClinicalTrials...
2017: PloS One
https://www.readbyqxmd.com/read/28817616/patterns-of-statin-non-prescription-in-patients-with-established-coronary-artery-disease-a-report-from-a-contemporary-multicenter-japanese-pci-registry
#6
Mitsuaki Sawano, Shun Kohsaka, Takayuki Abe, Taku Inohara, Yuichiro Maekawa, Ikuko Ueda, Koichiro Sueyoshi, Masahiro Suzuki, Shigetaka Noma, Yohei Numasawa, Hiroaki Miyata, Keiichi Fukuda, Kim G Smolderen, John A Spertus
Statin therapy is regarded as an effective medication to reduce cardiovascular events in patients at higher risk for future incidence of coronary artery disease. However, very few studies have been conducted to examine its implementation in non-Western real-world practice. In this study, we sought to describe statin prescription patterns in relation to patient characteristics in a Japanese multicenter percutaneous coronary intervention (PCI) registry as a foundation for quality improvement. We studied 15,024 patients that were prospectively enrolled in the Japan Cardiovascular Database-Keio interhospital Cardiovascular Study Registry from January 2009 to August 2014...
2017: PloS One
https://www.readbyqxmd.com/read/28816497/inclusion-of-gaming-disorder-criteria-in-icd-11-a-clinical-perspective-in-favor
#7
Susumu Higuchi, Hideki Nakayama, Satoko Mihara, Masaki Maezono, Takashi Kitayuguchi, Takuma Hashimoto
Data from a specialist treatment facility for Internet addiction (IA) in Japan showed that (a) the vast majority of treatment seekers are addicted to online games, (b) their symptoms are often quite severe, and (c) there is a significant demand for IA treatment. In addition, systemic obstacles to the delivery of medical services in Japan exist due to the exclusion of IA criteria from ICD-10. Consequently, the inclusion of GD criteria in ICD-11 will almost certainly increase the capacity and quality of treatment through advances in research and possible changes in national medical systems to meet treatment demand...
August 17, 2017: Journal of Behavioral Addictions
https://www.readbyqxmd.com/read/28815982/bridge-the-gap-the-need-for-harmonized-regulatory-and-ethical-standards-for-postmarketing-observational-studies
#8
REVIEW
Hisashi Urushihara, Louise Parmenter, Shimon Tashiro, Kenji Matsui, Nancy Dreyer
Drug safety issues do not respect national borders. Hence, addressing a safety question may necessitate globally coordinated efforts between regulatory authorities and market authorization holders (MAHs) to draw reliable conclusions. Regulatory authorities have shared responsibility with MAHs sponsoring postmarketing nonintervention studies in determining study goals and design. Their shared accountabilities include what will be investigated and how the data will be retrieved to ensure appropriate study quality required for regulatory decision making...
August 16, 2017: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/28815860/anxieties-felt-by-ccss-after-treatment-and-the-need-for-continued-support
#9
Naoko Iwai, Akira Shimada, Atsushi Iwai, Sonoe Yamaguchi, Hirokazu Tsukahara, Megumi Oda
BACKGROUND: Childhood cancer survivors (CCSs) and their family members continue to live in fear even after treatment is concluded due to concerns about late effects and recurrences. The consequent long-term psychological burden requires long-term follow-up suited to the anxieties and needs of CCSs, which is why we have conducted the present survey. METHODS: We conducted a questionnaire survey at medical facilities in the Chugoku and Shikoku regions of Japan with CCSs who had survived for at least 5 years following treatment, and their family members...
August 16, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/28814701/-byoin-in-modern-japan-focusing-on-the-terminological-introduction-of-hospital-and-the-complex-formation-of-its-concept
#10
Youngsoo Kim
This paper aims to clarify when the term of Byoin (hospital) was introduced and how its concept was developed in modern Japan. The word "Byoin" was introduced in Japan in 1787 for the first time, but it had not been in use until early 1860s. Instead, various medical institutions performing the functions of modern medical facilities, such as Yojosho (A place for preserving health), Shijuku (private school), called by traditional names as ever. Japanese intellectuals already adopted the word Byoin and the concept of western hospital in early 1860s when their national delegates were dispatched to Europe to revise the treaties forged with western powers...
April 2017: Ŭi Sahak
https://www.readbyqxmd.com/read/28811927/premature-deaths-among-individuals-with-severe-mental-illness-after-discharge-from-long-term-hospitalisation-in-japan-a-naturalistic-observation-during-a-24-year-period
#11
Shinsuke Kondo, Yousuke Kumakura, Akiko Kanehara, Daisuke Nagato, Taro Ueda, Tsuneo Matsuoka, Yukiko Tao, Kiyoto Kasai
BACKGROUND: Premature death in individuals with severe mental illness (SMI) in countries without nationally collected data, including Japan, is structurally underreported. AIMS: To elucidate excess mortality among individuals with SMI in Japan. METHOD: We retrospectively investigated all deaths among users of a non-clinical community-based mental health service provider in suburban Tokyo from 1992 to 2015. RESULTS: During the study period, 45 individuals died among 254 qualified registrants...
July 2017: BJPsych Open
https://www.readbyqxmd.com/read/28810984/impact-of-a-7-day-field-training-on-oral-health-condition-in-japan-ground-self-defense-force-personnel
#12
Koji Yamashita, Takeshi Nishiyama, Emi Nagata, Atik Ramadhani, Miki Kawada-Matsuo, Hitoshi Komatsuzawa, Takahiko Oho
INTRODUCTION: In the Japan Ground Self-Defense Force (JGSDF), personnel periodically perform intensive training that mimics the conditions seen in battle and during natural disasters. Military training involves intensive, stressful conditions, and changes in immune responses have been found in personnel following training. Good oral condition is important for military personnel to fulfill their duties; however, they have difficulty performing daily oral care under training conditions...
July 2017: Military Medicine
https://www.readbyqxmd.com/read/28808952/effect-of-reducing-cost-sharing-for-outpatient-care-on-children-s-inpatient-services-in-japan
#13
Hirotaka Kato, Rei Goto
BACKGROUND: Assessing the impact of cost sharing on healthcare utilization is a critical issue in health economics and health policy. It may affect the utilization of different services, but is yet to be well understood. OBJECTIVE: This paper investigates the effects of reducing cost sharing for outpatient services on hospital admissions by exploring a subsidy policy for children's outpatient services in Japan. METHODS: Data were extracted from the Japanese Diagnosis Procedure Combination database for 2012 and 2013...
August 15, 2017: Health Economics Review
https://www.readbyqxmd.com/read/28807165/effect-and-mechanism-of-chinese-herbal-medicine-on-parkinson-s-disease
#14
Bai-Yun Zeng
Parkinson's disease is a progressive neurodegenerative disorder. Although both genetic and environmental factors are implicated in the development of Parkinson's disease, the cause of the disease is still unclear. So far conventional treatments to Parkinson's are symptomatic relief and focused mainly on motor symptoms. Chinese herbal medicine has been used to treat many conditions in China, Korea, Japan, and many Southeast Asian countries for 1000 years. During past a few decades, Chinese herbal medicine has gained wider and increasing acceptance within both public and medical profession due to its effectiveness on many conditions in western countries...
2017: International Review of Neurobiology
https://www.readbyqxmd.com/read/28801834/current-characteristics-and-management-of-congenital-esophageal-stenosis-40-consecutive-cases-from-a-multicenter-study-in-the-kyushu-area-of-japan
#15
Masaya Suzuhigashi, Tatsuru Kaji, Hiroyuki Noguchi, Mitsuru Muto, Michiko Goto, Motoi Mukai, Kazuhiko Nakame, Takafumi Kawano, Waka Yamada, Koji Yamada, Shun Onishi, Satoshi Ieiri
PURPOSE: Congenital esophageal stenosis (CES) is rare, and the available clinical data are limited. We explored the current diagnosis, treatment and outcomes of CES. METHODS: A questionnaire survey was performed using medical records at pediatric surgical centers in the Kyushu area. RESULTS: Over 10 years, 40 patients (24 males) had CES. The incidence of associated anomalies was 52.5% (21/40), and that of esophageal atresia was 20.0% (8/40)...
August 11, 2017: Pediatric Surgery International
https://www.readbyqxmd.com/read/28801436/effect-of-endoscopic-transpapillary-biliary-drainage-with-without-endoscopic-sphincterotomy-on-post-endoscopic-retrograde-cholangiopancreatography-pancreatitis-in-patients-with-biliary-stricture-e-best-a-protocol-for-a-multicentre-randomised-controlled-trial
#16
Shin Kato, Masaki Kuwatani, Ryo Sugiura, Itsuki Sano, Kazumichi Kawakubo, Kota Ono, Naoya Sakamoto
INTRODUCTION: The effect of endoscopic sphincterotomy prior to endoscopic biliary stenting to prevent post-endoscopic retrograde cholangiopancreatography pancreatitis remains to be fully elucidated. The aim of this study is to prospectively evaluate the non-inferiority of non-endoscopic sphincterotomy prior to stenting for naïve major duodenal papilla compared with endoscopic sphincterotomy prior to stenting in patients with biliary stricture. METHODS AND ANALYSIS: We designed a multicentre randomised controlled trial, for which we will recruit 370 patients with biliary stricture requiring endoscopic biliary stenting from 26 high-volume institutions in Japan...
August 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/28795466/reduced-prevalence-of-hepatitis-b-surface-antigen-positivity-among-pregnant-women-born-after-the-national-implementation-of-immunoprophylaxis-for-babies-born-to-hepatitis-b-virus-carrier-mothers-in-japan
#17
Aya Sugiyama, Masayuki Ohisa, Shintaro Nagashima, Chikako Yamamoto, Chuon Channarena, Toshiko Fujii, Tomoyuki Akita, Keiko Katayama, Yoshiki Kudo, Junko Tanaka
AIM: We aimed to estimate hepatitis B surface antigen (HBsAg) positivity among birth year-stratified pregnant women in Hiroshima, Japan, and compare prevalence rates among women between born before and after implementation of a national immunoprophylactic vaccination program for babies born to hepatitis B virus (HBV) carrier mothers in Japan. METHODS: Pregnant women who gave birth at all delivery hospitals/clinics in Hiroshima prefecture between April 1, 2010 and March 31, 2011 were eligible...
August 9, 2017: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/28794693/human-genetics-in-troubled-times-and-places
#18
REVIEW
Peter S Harper
The development of human genetics world-wide during the twentieth century, especially across Europe, has occurred against a background of repeated catastrophes, including two world wars and the ideological problems and repression posed by Nazism and Communism. The published scientific literature gives few hints of these problems and there is a danger that they will be forgotten. The First World War was largely indiscriminate in its carnage, but World War 2 and the preceding years of fascism were associated with widespread migration, especially of Jewish workers expelled from Germany, and of their children, a number of whom would become major contributors to the post-war generation of human and medical geneticists in Britain and America...
2018: Hereditas
https://www.readbyqxmd.com/read/28794428/japan-s-initiative-on-rare-and-undiagnosed-diseases-irud-towards-an-end-to-the-diagnostic-odyssey
#19
Takeya Adachi, Kazuo Kawamura, Yoshihiko Furusawa, Yuji Nishizaki, Noriaki Imanishi, Senkei Umehara, Kazuo Izumi, Makoto Suematsu
Japan has been facing challenges relating to specifically defined rare diseases, called Nan-Byo in Japanese (literally 'difficult'+'illness'), and has already taken measures for them since 1972. This governmental support has surely benefited Nan-Byo patients; however, those suffering from medically unidentified conditions do not fall into this scheme and thus still confront difficulty in obtaining an examination, a diagnosis, and a treatment. To identify such rare and often undiagnosed diseases, we must integrate systematic diagnosis by medical experts with phenotypic and genetic data matching...
September 2017: European Journal of Human Genetics: EJHG
https://www.readbyqxmd.com/read/28794386/overview-of-the-81-st-annual-scientific-meeting-of-the-japanese-circulation-society%C3%A3-cardiovascular-medicine-for-the-next-generation
#20
Noboru Fujino, Tsuyoshi Yoshimuta, Fukiko Ichida, Koichiro Kinugawa, Kazuo Usuda, Michihiko Kitayama, Hidekazu Ino, Masa-Aki Kawashiri, Hiroshi Tada, Sumio Mizuno, Kenshi Hayashi, Hirofumi Takemura, Masakazu Yamagishi
The 81(st)Annual Scientific Meeting of the Japanese Circulation Society was held in Kanazawa, Japan, on March 17-19, 2017 under a miraculously clear sky. The frontlines of healthcare and medicine are dramatically changing. Thus, "Cardiovascular Medicine for Next Generation" was chosen as the main theme of this meeting. The program was constructed around major identified issues, including renewal of our understanding of basic cardiovascular medicine, translational research, and preventive molecular medicine, all of which are anticipated to transcend the medical field over the next generation...
August 8, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
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