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https://www.readbyqxmd.com/read/29451658/clinical-correlation-of-biopsy-results-in-patients-with-temporal-arteritis
#1
Volkan Yuksel, Orkut Guclu, Ebru Tastekin, Umit Halici, Serhat Huseyin, Volkan Inal, Suat Canbaz
OBJECTIVE: Temporal arteritis is systemic vasculitis of medium and large sized vessels. The lowest incidence rates were reported in Turkey, Japan and Israel. We aimed to investigate the results of patients with biopsy-proven temporal arteritis and those classified according to the American College of Rheumatology criteria from a low-incidence region for temporal arteritis. The results of our study are noteworthy, since there is limited data on pathologic diagnosis of temporal arteritis in Turkey...
November 2017: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/29451047/national-survey-of-japanese-patients-with-mevalonate-kinase-deficiency-reveals-distinctive-genetic-and-clinical-characteristics
#2
Takayuki Tanaka, Kohei Yoshioka, Ryuta Nishikomori, Hidemasa Sakai, Junya Abe, Yuriko Yamashita, Ryugo Hiramoto, Akira Morimoto, Eiichi Ishii, Hirokazu Arakawa, Utako Kaneko, Yusei Ohshima, Nami Okamoto, Osamu Ohara, Ikue Hata, Yosuke Shigematsu, Tomoki Kawai, Takahiro Yasumi, Toshio Heike
OBJECTIVES: Mevalonate kinase deficiency (MKD), a rare autosomal recessive autoinflammatory syndrome, is caused by disease-causing variants of the mevalonate kinase gene. A national survey was undertaken to investigate clinical and genetic features of MKD patients in Japan. METHODS: The survey identified ten patients with MKD. Clinical information and laboratory data were collected from medical records and by direct interviews with patients, their families, and their attending physicians...
February 16, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/29448921/evaluation-of-risk-factors-for-perforated-peptic-ulcer
#3
Kazuki Yamamoto, Osamu Takahashi, Hiroko Arioka, Daiki Kobayashi
BACKGROUND: The aim of this study was to evaluate the prediction factors for perforated peptic ulcer (PPU). METHODS: At St. Luke's International Hospital in Tokyo, Japan, a case control study was performed between August 2004 and March 2016. All patients diagnosed with PPU were included. As control subjects, patients with age, sex and date of CT scan corresponding to those of the PPU subjects were included in the study at a proportion of 2 controls for every PPU subject...
February 15, 2018: BMC Gastroenterology
https://www.readbyqxmd.com/read/29445943/impact-of-the-clinical-use-of-rock-inhibitor-on-the-pathogenesis-and-treatment-of-glaucoma
#4
REVIEW
Megumi Honjo, Hidenobu Tanihara
Rho-associated protein kinase (ROCK), a ubiquitously expressed signaling messenger and downstream effector of Rho, is activated by several bioactive factors in the aqueous humor (AH). Rho-ROCK signaling regulates a wide spectrum of fundamental cellular events, including cell adhesion, motility, proliferation, differentiation, and apoptosis. Previous studies, including our own, found that ROCK inhibitor lowers intraocular pressure (IOP) via a direct effect on the conventional AH outflow pathway, by regulation of contractile properties, fibrotic activity, and permeability of the trabecular meshwork (TM) and Schlemm's canal (SC) tissues, influencing extracellular matrix (ECM) production...
February 14, 2018: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29445511/management-of-group-b-streptococcus-positive-pregnant-women-at-maternity-homes-in-japan-a-questionnaire-survey-of-compliance-among-midwives
#5
Kotomi Yamaguchi, Kazutomo Ohashi
Background: Per the 2014 Japanese Midwives Association (JMA) guidelines, midwives were allowed to manage the deliveries for group B streptococcus (GBS)-positive pregnant women in labour at maternity homes without the supervision of a medical doctor if they complied with the guidelines of the Japan Society of Obstetrics and Gynecology (JSOG), wherein midwives working for maternity homes are expected to cooperate with commissioned obstetricians and paediatricians in cooperative medical facilities...
2018: Maternal Health, Neonatology and Perinatology
https://www.readbyqxmd.com/read/29445508/development-of-the-japanese-version-of-the-preschool-confusion-assessment-method-for-the-icu
#6
Yujiro Matsuishi, Haruhiko Hoshino, Nobutake Shimojo, Yuki Enomoto, Takahiro Kido, Subrina Jesmin, Masahiko Sumitani, Yoshiaki Inoue
Aim: Delirium is associated with various negative clinical outcomes, such as decline in cognitive ability, increased length of hospital stay, and higher mortality. For these reasons, early diagnosis of delirium is critical. Unfortunately, there are no reliable diagnostic criteria or tool of delirium for infants and preschool-aged children in Japan. The aim of the present study was to translate a new delirium assessment tool, the Preschool Confusion Assessment Method for the Intensive Care Unit (psCAM-ICU), for accurately diagnosing clinically ill infants and preschool-aged children, from English to Japanese...
January 2018: Acute Medicine & Surgery
https://www.readbyqxmd.com/read/29445507/development-of-the-japanese-version-of-the-cornell-assessment-of-pediatric-delirium
#7
Haruhiko Hoshino, Yujiro Matsuishi, Nobutake Shimojo, Yuki Enomoto, Takahiro Kido, Yoshiaki Inoue
Aim: Delirium is a form of acute cerebral dysfunction and is associated with increased length of hospital stay, mortality, and health-care costs for adult patients in intensive care. However, in Japan, there are currently no reliable criteria or tools for diagnosing delirium in critically ill pediatric patients. The purpose of this study was to translate the Cornell Assessment of Pediatric Delirium (CAPD)-a screening tool for pediatric delirium-from English to Japanese for use in the diagnosis of delirium for pediatric patients in pediatric intensive care units...
January 2018: Acute Medicine & Surgery
https://www.readbyqxmd.com/read/29443366/paradoxical-anatomic-response-to-topical-carbonic-anhydrase-inhibitor-in-x-linked-retinoschisis
#8
Brandon Menke, Alex Walters, John F Payne
An 11-year-old boy presented for central vision blurring in each eye. Visual acuity was 20/80 and examination revealed spoke-wheel foveal schisis and peripheral elevated diaphanous inner retina in each eye. Spectral-domain optical coherence tomography showed inner-retinal, flat-topped cysts in each eye. Electrophysiologic testing was refused, but a clinical diagnosis of X-linked retinoschisis was made. Three months after topical dorzolamide (Trusopt; Santen Pharmaceutical, Osaka, Japan) was started, the macular cysts worsened significantly...
February 1, 2018: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/29441498/cost-of-illness-of-japanese-patients-with-chronic-lymphocytic-leukemia-cll-and-budget-impact-of-the-market-introduction-of-ibrutinib
#9
Jörg Mahlich, Shinichiro Okamoto, Akiko Tsubota
BACKGROUND: Ibrutinib was introduced in Japan in 2016 as a new oral treatment option for patients with relapsed/refractory (RR) chronic lymphocytic leukemia (CLL). There is increasing interest from the Japanese government to assess economic aspects of new medical interventions, especially in the area of oncology. OBJECTIVE: We describe the treatment patterns of Japanese patients with CLL, estimate the cost of the disease from a health insurance perspective, and predict the budget impact of the introduction of ibrutinib...
September 2017: PharmacoEconomics Open
https://www.readbyqxmd.com/read/29437992/-the-industry-must-be-inconspicuous-japan-tobacco-s-corruption-of-science-and-health-policy-via-the-smoking-research-foundation
#10
Kaori Iida, Robert N Proctor
OBJECTIVE: To investigate how and why Japan Tobacco, Inc. (JT) in 1986 established the Smoking Research Foundation (SRF), a research-funding institution, and to explore the extent to which SRF has influenced science and health policy in Japan. METHODS: We analysed documents in the Truth Tobacco Industry Documents archive, along with recent Japanese litigation documents and published documents. RESULTS: JT's effort to combat effective tobacco control was strengthened in the mid-1980s, following privatisation of the company...
February 4, 2018: Tobacco Control
https://www.readbyqxmd.com/read/29434957/experience-based-surgical-approach-to-pancreatic-mucinous-cystic-neoplasms-with-ovarian-type-stroma
#11
Chang Moo Kang, Akira Matsushita, Ho Kyoung Hwang, Yoko Matsuda, Hyunki Kim, Yoshiharu Nakamura, Woo Jung Lee
The present study aimed to elucidate the clinicopathological characteristics of resected mucinous cystic neoplasm (MCN) with ovarian-type stroma and identify a surgical approach for MCN treatment, on the basis of Republic of Korean (Yonsei University College of Medicine, Seoul, South Korea) and Japanese (Nippon Medical School, Tokyo, Japan) bi-institutional collaboration. The present study retrospectively reviewed 55 MCNs with ovarian-type stroma using pathological re-examination. Clinicopathological features and preoperative clinical parameters were evaluated to predict malignant alterations in MCNs...
February 2018: Oncology Letters
https://www.readbyqxmd.com/read/29434484/bacterial-pneumonia-in-elderly-japanese-populations
#12
REVIEW
Naoya Miyashita, Yasuhiro Yamauchi
Bacterial pneumonia is one of the most important infectious diseases in terms of incidence, effect on quality of life, mortality, and impact on society. Pneumonia was the third leading cause of death in Japan in 2011. In 2016, 119 650 Japanese people died of pneumonia, 96% of whom were aged 65 years and above. The symptoms of pneumonia in elderly people are often atypical. Aspiration pneumonia is seen more frequently than in young people because of swallowing dysfunction in the elderly. The mortality rate is also higher in the elderly than in young people...
2018: Japanese Clinical Medicine
https://www.readbyqxmd.com/read/29434175/can-hybrid-educational-activities-of-team-and-problem-based-learning-program-be-effective-for-japanese-medical-students
#13
Kentaro Iwata, Asako Doi
BACKGROUND: The purpose of this study is to investigate the medical students'perceptions of the Hybrid Educational Activities between team based learning (TBL) and problem based learning (PBL) Program (HEATAPP), a novel educational program that combines characteristics of PBL and TBL. METHODS: A five-day HEATAPP on infectious diseases was provided to 4th year medical students at Kobe University School of Medicine, Kobe, Japan. After the program, a focus group discussion was held among 6 medical students who participated in HEATAPP...
November 10, 2017: Kobe Journal of Medical Sciences
https://www.readbyqxmd.com/read/29434153/risk-factors-for-chest-pain-and-fever-in-patients-undergoing-pleurodesis-with-ok-432
#14
Yoshihito Morimoto, Hidefumi Takei, Keisei Tachibana, Yoko Nakazato, Ryota Tanaka, Yasushi Nagashima, Kazuhiro Watanabe, Reisuke Seki, Takao Shinohara, Haruhiko Kondo
Objective In Japan, pleurodesis is often performed using OK-432. However, OK-432 may cause severe chest pain and fever. The risk factors for these complications are unclear. The aim of this study was to identify the risk factors for chest pain and fever caused by pleurodesis with OK-432. Methods The clinical data of 94 patients who underwent pleurodesis with OK-432 were retrospectively analyzed. Patients who developed chest pain (indicated by a record of rescue pain medication) and/or fever (a recorded temperature of >38°C) were identified...
February 9, 2018: Internal Medicine
https://www.readbyqxmd.com/read/29434084/comprehensive-assessment-of-risk-factors-of-cause-specific-infant-deaths-in-japan
#15
Yui Yamaoka, Naho Morisaki, Haruko Noguchi, Hideto Takahashi, Nanako Tamiya
BACKGROUND: Public attention is given to infants with socially high risks of child abuse and neglect, while clinical attention is provided to infants with a biologically high risk of diseases. However, few studies have systematically evaluated how biological or social factors cross over and affect cause-specific infant mortality. METHODS: We linked birth data with death data from the Japanese national vital statistics database for all infants born from 2003-2010...
February 10, 2018: Journal of Epidemiology
https://www.readbyqxmd.com/read/29432515/urinary-angiotensinogen-excretion-level-is-associated-with-elevated-blood-pressure-in-the-normotensive-general-population
#16
Emiko Sato, An Yi Wang, Michihiro Satoh, Yoko Nishikiori, Ikuko Oba-Yabana, Mai Yoshida, Hiroshi Sato, Sadayoshi Ito, Wataru Hida, Takefumi Mori
Background: Inflammation, intrarenal renin-angiotensin system activation, oxidative stress, and carbonyl stress have been postulated to play a fundamental role in controlling blood pressure. However, little is known about the association among renal renin-angiotensin system activation, carbonyl stress, and blood pressure elevation. Methods: We evaluated the relationship between blood pressure elevation and either renal renin-angiotensin system activity or carbonyl stress in the general population (N=355) in Japan...
February 8, 2018: American Journal of Hypertension
https://www.readbyqxmd.com/read/29432459/use-of-count-based-image-reconstruction-to-evaluate-the-variability-and-repeatability-of-measured-standardised-uptake-values
#17
Tomohiro Kaneta, Hiromitsu Daisaki, Matsuyoshi Ogawa, En-Tao Liu, Hitoshi Iizuka, Tetsu Arisawa, Ayako Hino-Shishikura, Keisuke Yoshida, Tomio Inoue
Standardized uptake values (SUVs) are the most widely used quantitative imaging biomarkers in PET. It is important to evaluate the variability and repeatability of measured SUVs. Phantom studies seem to be essential for this purpose; however, repetitive phantom scanning is not recommended due to the decay of radioactivity. In this study, we performed count-based image reconstruction to avoid the influence of decay using two different PET/CT scanners. By adjusting the ratio of 18F-fluorodeoxyglucose solution to tap water, a NEMA IEC body phantom was set for SUVs of 4...
2018: PloS One
https://www.readbyqxmd.com/read/29429636/the-expand-study-efficacy-and-safety-of-rivaroxaban-in-japanese-patients-with-non-valvular-atrial-fibrillation
#18
Hiroaki Shimokawa, Takeshi Yamashita, Shinichiro Uchiyama, Takanari Kitazono, Wataru Shimizu, Takanori Ikeda, Masahiro Kamouchi, Koichi Kaikita, Koji Fukuda, Hideki Origasa, Ichiro Sakuma, Keijiro Saku, Yasuo Okumura, Yuichiro Nakamura, Hideo Morimoto, Naoki Matsumoto, Akihito Tsuchida, Junya Ako, Nobuyoshi Sugishita, Shogo Shimizu, Hirotsugu Atarashi, Hiroshi Inoue
AIMS: The EXPAND study examined the real-world efficacy and safety of rivaroxaban for the prevention of stroke and systemic embolism (SE) in Japanese patients with non-valvular atrial fibrillation (NVAF). METHODS AND RESULTS: This multicenter, prospective, non-interventional, observational, cohort study was conducted at 684 medical centers in Japan. A total of 7141 NVAF patients ≥20 years of age (mean, 71.6 ± 9.4 years) who were being or about to be treated with rivaroxaban (10 mg/day, 43...
February 3, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29429288/-study-on-the-difference-of-binocular-accommodative-response-between-atients-with-intermittent-exotropia-under-different-viewing-condition
#19
P C Shen, Y Zhang, Y Liu, J Jiang, J J Xu, H L Lin, D Xu
Objective: To evaluate the accommodative response of patients with intermittent exotropia (IXT) objectively, and study the changes of accommodative response of intermittent exotropia patients when maintaining binocular fusion. Methods: The prospective cohort study was used in this study. Twenty-four patients diagnosed with basic intermittent exotropia who visited the eye hospital of Wenzhou Medical University during October 2016 through January 2017 together with 24 normal volunteers were included, the 48 participants aged from 10 to 27 years old...
January 11, 2018: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29425381/automatic-acquisition-of-ct-radiation-dose-data-using-the-diagnostic-reference-level-for-radiation-dose-optimization
#20
Yoshihiro Nakada, Yasuo Okuda, Tatsuya Tsuge, Jyunichi Suzuki, Hiroshi Sakamoto, Tsuyoshi Yamamoto, Yasuhiko Konishi, Takeshi Tsujimoto, Shigeo Nishiki, Toshimitsu Satoh, Nobukazu Aoyama, Kyohei Morimoto, Masamichi Aita, Yusuke Yamashita, Takayasu Yoshitake, Masami Mukai, Yuki Yokooka, Noriya Yokohama, Keiichi Akahane
The present work describes that we try to construct a system that collects dose information that performed CT examination from multiple facilities and unified management. The results of analysis are compared with other National diagnostic reference level (DRL), and the results are fed back to each facility and the cause of the abnormal value is investigated for dose optimization. Medical information collected 139 144 tests from 33 CT devices in 13 facilities. Although the DRL of this study is lower than that of Japan DRL, it was higher than the DRL of each country...
February 7, 2018: Radiation Protection Dosimetry
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