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https://www.readbyqxmd.com/read/29225966/changes-in-glaucoma-medication-during-the-past-eight-years-and-future-directions-in-japan-based-on-an-insurance-medical-claim-database
#1
Masako Sakamoto, Kazuyoshi Kitamura, Kenji Kashiwagi
Purpose: To investigate changes in the status of glaucoma care between 2006 and 2013 and to predict future directions of glaucoma care in Japan. Subjects and Methods: Japanese subjects registered in the largest national insurance claim database in Japan from 2006 to 2013 were analyzed. Estimations of the number of glaucoma patients during the past eight years and of the number of future patients were calculated. Changes in prescription trends among the same patients in the three-year period after initiating antiglaucoma medication were also investigated...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/29225909/improved-treatment-satisfaction-and-medication-adherence-after-readjusting-oral-medication-regimens-with-the-cooperation-of-health-insurance-pharmacy-in-type-2-diabetic-patients-in-japan
#2
Naoko Ogawa, Mitsuyoshi Takahara, Toshihiko Shiraiwa, Mayumi Yamamoto, Kaoru Yamamoto, Masayuki Doi, Yoko Yoshida, Setsuko Gotou
Background: Treatment satisfaction and medication adherence can be improved if physicians carefully monitor the situations, check the level of difficulties patients experience when taking medications at specific times, and readjust medication regimens based on this information. However, physicians in Japan encounter difficulties in taking enough time to collect this information in clinical practice. The aim of the current study was to investigate improvements in satisfaction and adherence with the cooperation of a health insurance pharmacy in clinical practice...
2017: Journal of Pharmaceutical Health Care and Sciences
https://www.readbyqxmd.com/read/29224787/global-research-output-in-antimicrobial-resistance-among-uropathogens-a-bibliometric-analysis-2002-2016
#3
Waleed M Sweileh, Samah W Al-Jabi, Sa 'ed H Zyoud, Ansam F Sawalha, Adham S Abu-Taha
BACKGROUND: Antimicrobial resistance (AMR) among uropathogens contributes to treatment failure. Research in AMR among uropathogens is important to establish treatment. The aim of this study was to assess global research trends in AMR among uropathogens. METHODS: Sciverse Scopus was used to retrieve relevant documents for the period from 2002 to 2016. Only journal articles were included in the analysis. Analysis of author keywords was carried out using VOSviewer...
December 7, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/29224639/a-multinational-clinical-approach-to-assessing-the-effectiveness-of-catheter-based-ultrasound-renal-denervation-the-radiance-htn-and-require-clinical-study-designs
#4
Laura Mauri, Kazuomi Kario, Jan Basile, Joost Daemen, Justin Davies, Ajay J Kirtane, Felix Mahfoud, Roland E Schmieder, Michael Weber, Shinsuke Nanto, Michel Azizi
Catheter-based renal denervation is a new approach to treat hypertension via modulation of the renal sympathetic nerves. Although nonrandomized and small, open-label randomized studies resulted in significant reductions in office blood pressure 6months after renal denervation with monopolar radiofrequency catheters, the first prospective, randomized, sham-controlled study (Symplicity HTN-3) failed to meet its blood pressure efficacy end point. New clinical trials with new catheters have since been designed to address the limitations of earlier studies...
January 2018: American Heart Journal
https://www.readbyqxmd.com/read/29224056/a-5-year-multicenter-prospective-cohort-study-on-the-long-term-visual-prognosis-and-predictive-factors-for-visual-outcome-in-japanese-patients-with-age-related-macular-degeneration-the-amd2000-study
#5
Yumiko Akagi-Kurashige, Akitaka Tsujikawa, Mitsuko Yuzawa, Tatsuro Ishibashi, Hideo Nakanishi, Eiji Nakatani, Satoshi Teramukai, Masanori Fukushima, Nagahisa Yoshimura
PURPOSE: In this study (AMD2000), we aimed to determine the visual prognosis of Japanese patients with age-related macular degeneration (AMD). METHODS: This was a multicenter prospective observational cohort study. In total, 460 patients with AMD were recruited from April 2006 to March 2009 from 18 clinical trial sites in Japan. They were followed up for 5 years, as they continued to receive medical treatment. RESULTS: Of the 409 study eyes followed up for at least 1 year, 243 eyes (59...
December 9, 2017: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29223918/postmortem-computed-tomography-findings-in-cases-of-bath-related-death-applicability-and-limitation-in-forensic-practice
#6
Satoko Mishima, Hideto Suzuki, Tatsushige Fukunaga, Yoko Nishitani
PURPOSE: Bath-related deaths occur frequently in Japan, and many of these deaths are diagnosed as death from disease without autopsy in the current Japanese death-investigation system. Therefore, we aimed to examine the postmortem computed tomography (PMCT) findings of bath-related deaths to determine if PMCT can differentiate between real cases of drowning and sudden deaths not related to drowning. METHODS: Bath-related deaths were sampled from all autopsies conducted at the Tokyo Medical Examiner's Office from September 2015 to August 2016...
December 2, 2017: Forensic Science International
https://www.readbyqxmd.com/read/29221971/preventive-treatment-with-lomerizine-increases-cerebral-blood-flows-during-the-interictal-phase-of-migraine
#7
Ken Ikeda, Joe Aoyagi, Sayori Hanashiro, Masahiro Sawada, Maya Kyuzen, Harumi Morioka, Junya Ebina, Junpei Nagasawa, Masaru Yanagihashi, Yuichi Ishikawa, Ken Miura, Kiyoko Murata, Takanori Takazawa, Kiyokazu Kawabe, Yasuo Iwasaki
BACKGROUND: Changes in regional cerebral blood flow (rCBF) were reported in migraineurs. However, little is known how preventive medications of migraine can influence rCBF. Lomerizine, a calcium channel blocker, has been used for migraine prophylaxis in Japan. We examined rCBF after lomerizine treatment. SUBJECTS AND METHODS: Migraine was diagnosed according to the criteria of the International Classification of Headache Disorders, Third Edition beta. Migraine subtype was classified into migraine with aura (MA) and migraine without aura (MO)...
December 5, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29221890/22nd-international-conference-on-medical-physics-2016-bangkok-thailand-medical-physics-propelling-global-health
#8
EDITORIAL
Virginia Tsapaki, Geoff Ibbott, Anchali Krisanachinda, Kwan-Hoong Ng, Tae-Suk Suh, Slavik Tabakov, John Damilakis
As medical technology evolves and patient needs increase, the need for well-trained and highly professional medical physicists (MPs) becomes even more urgent. The roles and responsibilities of MPs in various departments within the hospital are diverse and demanding. It is obvious that training, continuing education and professional development of MPs have become essential. One of the ways for an MP to advance his or her knowledge is to participate in conferences and congresses. Last year, the 22nd International Conference of Medical Physics (ICMP 2016) took place in Bangkok, Thailand...
December 6, 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/29221489/characteristics-of-the-use-of-cold-combination-products-among-older-ambulatory-patients-at-the-national-hospital-organization-tochigi-medical-center-in-japan-a-retrospective-single-center-observational-study
#9
Junpei Komagamine
OBJECTIVE: This study aimed to determine the frequency and characteristics of prescriptions of cold combination products among older ambulatory patients. A retrospective observational study was conducted using electronic medical records. All patients aged 65 years or older who continued visiting internal medicine physicians for at least 1 year were included. The primary outcome was the prescription of cold combination products by any physicians in National Hospital Organization Tochigi Medical Center during a 1-year follow-up...
December 8, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/29220825/effects-of-nutritional-education-on-weight-change-and-metabolic-abnormalities-among-patients-with-schizophrenia-in-japan-a-randomized-controlled-trial
#10
Norio Sugawara, Toyoaki Sagae, Norio Yasui-Furukori, Manabu Yamazaki, Kazutaka Shimoda, Takao Mori, Takuro Sugai, Hiroshi Matsuda, Yutaro Suzuki, Yuji Ozeki, Kurefu Okamoto, Toshiyuki Someya
OBJECTIVE: Patients with schizophrenia have a higher prevalence of metabolic syndrome (MetS) than the general population. Minimizing weight gain and metabolic abnormalities in a population with an already high prevalence of obesity is of clinical and social importance. This randomized controlled trial investigated the effect of monthly nutritional education on weight change and metabolic abnormalities among patients with schizophrenia in Japan. METHODS: From July 2014 to December 2014, we recruited 265 obese patients who had a DSM-IV diagnosis of schizophrenia or schizoaffective disorder...
December 4, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/29220371/the-impact-of-different-anti-vascular-endothelial-growth-factor-treatment-regimens-on-reducing-burden-for-caregivers-and-patients-with-wet-age-related-macular-degeneration-in-a-single-center-real-world-japanese-setting
#11
Tsukasa Hanemoto, Yusuke Hikichi, Norimasa Kikuchi, Tadahiko Kozawa
OBJECTIVE: To describe the burden associated with different anti-vascular endothelial growth factor (VEGF) treatment strategies for wet age-related macular degeneration (wAMD) in a real-word setting in Japan. METHODS: Single-center, cross-sectional survey of caregivers of patients with wAMD performed in a hospital in Mito-City, a rural area in Japan. Caregiver burden was evaluated using the Burden Index of Caregivers (BIC-11), and depressive symptoms were assessed by the Center for Epidemiologic Studies Depression scale...
2017: PloS One
https://www.readbyqxmd.com/read/29218315/a-novel-lens-cleaner-to-prevent-water-drop-adhesions-during-colonoscopy-and-esophagogastroduodenoscopy
#12
Naohisa Yoshida, Yuji Naito, Ritsu Yasuda, Takaaki Murakami, Kiyoshi Ogiso, Ryohei Hirose, Yutaka Inada, Osamu Dohi, Tetsuya Okayama, Kazuhiro Kamada, Kazuhiko Uchiyama, Takeshi Ishikawa, Osamu Handa, Hideyuki Konishi, Rafiz Abdul Rani, Yoshito Itoh
Background and study aims:  Water drop adhesions (WDA) impair endoscopic view during gastrointestinal endoscopy. We developed a novel lens cleaner designed using two types of harmLess surfactants and it is reported to be useful for preventing lens cloudiness during colorectal ESD. In the current study, we examined the ability of it for preventing and removing WDA. Patients and methods:  During laboratory experiments, the cleaner (Cleash; Fujifilm Co., Tokyo, Japan and Nagase Medicals Co...
December 2017: Endoscopy International Open
https://www.readbyqxmd.com/read/29217459/technical-aspects-of-microphysiological-systems-mps-as-a-promising-wet-human-in-vivo-simulator
#13
REVIEW
Toshiyuki Kanamori, Shinji Sugiura, Yasuyuki Sakai
Microphysiological systems (MPS) are currently attracting a lot of interest from pharmaceutical companies worldwide. In the United States and European Union, several large government projects related to MPS have been initiated, and, in Japan, pharmaceutical companies interested in MPS are watching the recent trends and developments in the field. In July 2017, the Japan Agency for Medical Research and Development initiated a research program to develop chip-based MPS. In this review, we examine the technical aspects of commercializing chip-based MPS...
November 23, 2017: Drug Metabolism and Pharmacokinetics
https://www.readbyqxmd.com/read/29216912/changes-in-salivary-oxytocin-after-inhalation-of-clary-sage-essential-oil-scent-in-term-pregnant-women-a-feasibility-pilot-study
#14
Yuriko Tadokoro, Shigeko Horiuchi, Kaori Takahata, Takuya Shuo, Erika Sawano, Kazuyuki Shinohara
OBJECTIVES: This pilot study using a quasi-experimental design was conducted to evaluate the feasibility (i.e., limited efficacy, practicality, and acceptability) of our intervention protocol involving inhalation of the scent of clary sage essential oil by pregnant women and measurement of their preinhalation and postinhalation oxytocin levels. RESULTS: Participants were women of singleton pregnancies between 38 and 40 gestation weeks (N = 11). The experiment group (n = 5) inhaled the scent of clary sage essential oil diluted 50-fold with 10 mL of odorless propylene glycol for 20 min...
December 8, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/29214702/skin-injuries-and-joint-contractures-of-the-upper-extremities-in-rett-syndrome
#15
D Hirano, T Taniguchi
OBJECTIVES: The purpose of this study was to investigate the incidence and type of skin injuries and joint contractures of the upper extremities in individuals with Rett syndrome. METHODS: In 2016, a questionnaire regarding skin injuries and joint contractures was sent to 1016 directors of schools for special needs education and 204 directors of departments of rehabilitation [consisting of 130 facilities for persons with severe motor and intellectual disabilities (SMID), 73 wards for patients with SMID, and the National Hospital Organisation and National Centre Hospital, National Centre of Neurology and Psychiatry] in Japan...
January 2018: Journal of Intellectual Disability Research: JIDR
https://www.readbyqxmd.com/read/29213010/continuous-improvement-of-fitness-for-duty-management-programs-for-workers-engaging-in-stabilizing-and-decommissioning-work-at-the-fukushima-daiichi-nuclear-power-plant
#16
Koji Mori, Seiichiro Tateishi, Tatsuhiko Kubo, Yuichi Kobayashi, Ko Hiraoka, Futoshi Kawashita, Takeshi Hayashi, Yoshifumi Kiyomoto, Masaki Kobashi, Kota Fukai, Hiroyuki Tahara, Ryuji Okazaki, Akira Ogami, Kazuyuki Igari, Katsunori Suzuki, Hiroshi Kikuchi, Kazuhiro Sakai
BACKGROUND: Numerous workers have participated in recovery efforts following the accident that occurred at the Tokyo Electric Power Company (TEPCO) Fukushima Daiichi Nuclear Power Plant after the Great East Japan Earthquake. These workers, belonging to various companies, have been engaged in various tasks since the accident. Given the hazards and stress involved in these tasks and the relatively long time required to transport sick or injured workers to medical institutions, it became necessary to quickly implement a more stringent management program for fitness for duty than in ordinary work environments...
December 6, 2017: Journal of Occupational Health
https://www.readbyqxmd.com/read/29207078/characterizing-key-nucleotide-polymorphisms-of-hepatitis-c-virus-disease-associations-via-mass-spectrometric-genotyping
#17
Yuta Horiuchi, Jason Lin, Yui Shinojima, Kyoko Fujiwara, Mitsuhiko Moriyama, Hiroki Nagase
As more than 80% of hepatocellular carcinoma patients in Japan also suffer from hepatitis C virus infections some time in their medical history, identifying genetic aberrations associated to hepatitis C virulence in these individuals remains a high priority in the diagnosis and treatment of hepatocellular carcinoma. From the BioBank Japan Project, we acquired 480 subjects of hepatocellular carcinoma, chronic hepatitis and liver cirrhosis, and genotyped 131 clinically relevant host single nucleotide polymorphisms to survey the potential association between certain risk alleles and genes to a patient's predisposition to hepatitis C and liver cancer...
November 22, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/29205682/sibling-visitations-and-viral-infections-in-the-neonatal-intensive-care-unit
#18
Yuho Horikoshi, Kaoru Okazaki, Shigeko Miyokawa, Kazue Kinoshita, Hiroshi Higuchi, Junichi Suwa, Yuta Aizawa, Kahoru Fukuoka
BACKGROUND: Sibling visitations to the neonatal intensive care unit (NICU) are a part of family-centered care, which is now being increasingly endorsed as a positive development in patient care. However, sibling visitations pose a risk of viral infections such that many NICUs in Japan impose strict limits on the practice. The aim of our study was to assess whether sibling visitations to the NICU are related to an increase in the nosocomial viral infection rate. METHODS: This retrospective study was conducted between April 2012 and March 2017 at Tokyo Metropolitan Children's Medical Center in Japan...
December 5, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/29202795/validation-of-an-algorithm-that-determines-stroke-diagnostic-code-accuracy-in-a-japanese-hospital-based-cancer-registry-using-electronic-medical-records
#19
Yasufumi Gon, Daijiro Kabata, Keichi Yamamoto, Ayumi Shintani, Kenichi Todo, Hideki Mochizuki, Manabu Sakaguchi
BACKGROUND: This study aimed to validate an algorithm that determines stroke diagnostic code accuracy, in a hospital-based cancer registry, using electronic medical records (EMRs) in Japan. METHODS: The subjects were 27,932 patients enrolled in the hospital-based cancer registry of Osaka University Hospital, between January 1, 2007 and December 31, 2015. The ICD-10 (international classification of diseases, 10th revision) diagnostic codes for stroke were extracted from the EMR database...
December 4, 2017: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/29201642/the-effect-of-duration-of-illness-and-antipsychotics-on-subcortical-volumes-in-schizophrenia-analysis-of-778-subjects
#20
Naoki Hashimoto, Yoichi M Ito, Naohiro Okada, Hidenaga Yamamori, Yuka Yasuda, Michiko Fujimoto, Noriko Kudo, Ariyoshi Takemura, Shuraku Son, Hisashi Narita, Maeri Yamamoto, Khin Khin Tha, Asuka Katsuki, Kazutaka Ohi, Fumio Yamashita, Shinsuke Koike, Tsutomu Takahashi, Kiyotaka Nemoto, Masaki Fukunaga, Toshiaki Onitsuka, Yoshiyuki Watanabe, Hidenori Yamasue, Michio Suzuki, Kiyoto Kasai, Ichiro Kusumi, Ryota Hashimoto
Background: The effect of duration of illness and antipsychotic medication on the volumes of subcortical structures in schizophrenia is inconsistent among previous reports. We implemented a large sample analysis utilizing clinical data from 11 institutions in a previous meta-analysis. Methods: Imaging and clinical data of 778 schizophrenia subjects were taken from a prospective meta-analysis conducted by the COCORO consortium in Japan. The effect of duration of illness and daily dose and type of antipsychotics were assessed using the linear mixed effect model where the volumes of subcortical structures computed by FreeSurfer were used as a dependent variable and age, sex, duration of illness, daily dose of antipsychotics and intracranial volume were used as independent variables, and the type of protocol was incorporated as a random effect for intercept...
2018: NeuroImage: Clinical
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