Ryan S Anderson, Alexander K Chu, Helena Rylander, Emily E Binversie, Ian D Duncan, Lauren Baker, Shahriar Salamat, Margaret M Patterson, Jordan Gruel, Nyah L Kohler, Hannah K Kearney, Shelby M Ale, Mehdi M Momen, Peter Muir, John P Svaren, Rebecca Johnson, Susannah J Sample
Late-onset peripheral neuropathy (LPN) is a heritable canine neuropathy commonly found in Labrador retrievers and is characterized by laryngeal paralysis and pelvic limb paresis. Our objective was to establish canine LPN as a model for human hereditary peripheral neuropathy by classifying it as either an axonopathy or myelinopathy and evaluating length-dependent degeneration. We conducted a motor nerve conduction study of the sciatic and ulnar nerves, electromyography (EMG) of appendicular and epaxial musculature, and histologic analysis of sciatic and recurrent laryngeal nerves in LPN-affected and control dogs...
March 2024: Journal of Comparative Neurology