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https://www.readbyqxmd.com/read/29434450/incidence-of-hepatocellular-carcinoma-in-patients-with-chronic-liver-disease-due-to-hepatitis-b-or-c-and-coinfected-with-the-human-immunodeficiency-virus-a-retrospective-cohort-study
#1
Patrícia Dos Santos Marcon, Cristiane Valle Tovo, Dimas Alexandre Kliemann, Patrícia Fisch, Angelo Alves de Mattos
AIM: To assess the incidence of hepatocellular carcinoma (HCC) in chronic liver disease due to hepatitis B virus (HBV) or hepatitis C virus (HCV) coinfected with human immunodeficiency virus (HIV). METHODS: A retrospective cohort study was performed, including patients with chronic liver disease due to HBV or HCV, with and without HIV coinfection. Patients were selected in the largest tertiary public hospital complex in southern Brazil between January 2007 and June 2014...
February 7, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29413883/the-role-of-regulatory-t-cells-in-immunopathogenesis-and-immunotherapy-of-viral-infections
#2
REVIEW
Ahmad Karkhah, Mostafa Javanian, Soheil Ebrahimpour
Two hepatotropic viruses hepatitis C virus (HCV) and hepatitis B virus (HBV) have been considered as the main cause of chronic viral infections. In addition, human immunodeficiency virus (HIV) attacks the immune system by eradication of some white blood cell (T-helper cell). The role of Tregs in HCV, HBV and HIV infections ranges from suppressing antiviral T cell responses to protecting tissues as liver and immune cells from immune mediated injury. In this review, we discuss the influence of regulatory T cells in immunopathology of specific viral infections including HCV, HBV and HIV by focusing on targeting Tregs as novel approach in vaccinology against viral infections...
January 29, 2018: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/29410097/hbv-bypasses-the-innate-immune-response-and-does-not-protect-hcv-from-antiviral-activity-of-interferon
#3
Pascal Mutz, Philippe Metz, Florian A Lempp, Silke Bender, Bingqian Qu, Katrin Schöneweis, Stefan Seitz, Thomas Tu, Agnese Restuccia, Jamie Frankish, Christopher Dächert, Benjamin Schusser, Ronald Koschny, Georgios Polychronidis, Peter Schemmer, Katrin Hoffmann, Thomas F Baumert, Marco Binder, Stephan Urban, Ralf Bartenschlager
BACKGROUND & AIMS: Hepatitis C virus (HCV) infection is sensitive to interferon (IFN)-based therapy whereas HBV infection is not. It is unclear whether HBV escapes detection by the IFN-mediated immune response or actively suppresses it. Moreover, little is known on how HBV and HCV influence each other in co-infected cells. We investigated interactions between HBV and the IFN-mediated immune response using HepaRG cells and primary human hepatocytes (PHHs). We analyzed the effects of HBV on HCV replication, and vice versa, at the single-cell level...
January 31, 2018: Gastroenterology
https://www.readbyqxmd.com/read/29404490/survival-following-hospitalization-with-hepatocellular-carcinoma-among-people-notified-with-hepatitis-b-or-c-virus-in-australia-2000-2014
#4
Reem Waziry, Jason Grebely, Janaki Amin, Maryam Alavi, Behzad Hajarizadeh, Jacob George, Gail V Matthews, Matthew Law, Gregory J Dore
We assessed trends in HCC survival in patients with hepatitis B virus (HBV) or hepatitis C virus (HCV) infection in New South Wales, Australia. Data on HBV (n = 54,399) and HCV (n = 96,908) notifications (1993-2012) were linked to a hospitalization database (July 2000-June 2014), the New South Wales Cancer Registry, and the New South Wales Death Registry. A total of 725 (1.3%) first HBV-hepatocellular carcinoma (HCC) and 1,309 (1.4%) first HCV-HCC hospitalizations were included. Death occurred in 60.4% of HBV-HCC and 69...
October 2017: Hepatology Communications
https://www.readbyqxmd.com/read/29399277/fatty-liver-disease-an-emerging-etiology-of-hepatocellular-carcinoma-in-argentina
#5
Federico Piñero, Josefina Pages, Sebastián Marciano, Nora Fernández, Jorge Silva, Margarita Anders, Alina Zerega, Ezequiel Ridruejo, Beatriz Ameigeiras, Claudia D'Amico, Luis Gaite, Carla Bermúdez, Manuel Cobos, Carlos Rosales, Gustavo Romero, Lucas McCormack, Virginia Reggiardo, Luis Colombato, Adrián Gadano, Marcelo Silva
AIM: To investigate any changing trends in the etiologies of hepatocellular carcinoma (HCC) in Argentina during the last years. METHODS: A longitudinal cohort study was conducted by 14 regional hospitals starting in 2009 through 2016. All adult patients with newly diagnosed HCC either with pathology or imaging criteria were included. Patients were classified as presenting non-alcoholic fatty liver disease (NAFLD) either by histology or clinically, provided that all other etiologies of liver disease were ruled out, fatty liver was present on abdominal ultrasound and alcohol consumption was excluded...
January 27, 2018: World Journal of Hepatology
https://www.readbyqxmd.com/read/29398866/vitamin-d-deficiency-and-hepatitis-viruses-associated-liver-diseases-a-literature-review
#6
REVIEW
Nghiem Xuan Hoan, Hoang Van Tong, Le Huu Song, Christian G Meyer, Thirumalaisamy P Velavan
The secosteroid hormone vitamin D has, in addition to its effects in bone metabolism also functions in the modulation of immune responses against infectious agents and in inhibiting tumorigenesis. Thus, deficiency of vitamin D is associated with several malignancies, but also with a plethora of infectious diseases. Among other communicable diseases, vitamin D deficiency is involved in the pathogenesis of chronic liver diseases caused by hepatitis B and C viruses (HBV, HCV) and high prevalence of vitamin D deficiency with serum levels below 20 mg/mL in patients with HBV and HCV infection are found worldwide...
January 28, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29397016/risk-of-hbv-reactivation-in-hbv-hcv-coinfected-patients-with-compensated-liver-cirrhosis-treated-with-ombitasvir-paritaprevir-r-dasabuvir-ribavirin
#7
Carmen Monica Preda, Corneliu Petru Popescu, Cristian Baicus, Ileana Constantinescu, Alexandru Oproiu, Theodor Voiosu, Mircea Diculescu, Lucian Negreanu, Liana Gheorghe, Ioan Sporea, Anca Trifan, Emanoil Ceausu, Doina Proca, Mircea Manuc
Hepatitis B virus may reactivate in patients with chronic hepatitis C treated with direct acting antivirals. The aim of the present study was to investigate the risk of HBV reactivation in HBV+HCV coinfected patients with compensated liver cirhosis treated with Paritaprevir/Ombitasvir/Ritonavir, Dasabuvir with Ribavirin. We reviewed prospectively gathered data from a national cohort of 2070 patients with hepatitis C virus compensated liver cirrhosis who received reimbursed Paritaprevir/ Ombitasvir /r, Dasabuvir with Ribavirin for 12 weeks from the Romanian National Health Agency during 2015-2016...
February 3, 2018: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/29391309/role-of-nucleoside-nucleotide-analogues-and-low-dose-hepatitis-b-immune-glob%C3%A3-lin-in-prophylaxis-of-hepatitis-b-recurrence-among-cadaveric-liver-transplant-recipients
#8
Tokunbo Ajayi, Harry Luu, Behnam Saberi, James P Hamilton, Bugra Tolga Konduk, Burak Özşeker, Kawtar Al Khalloufi, Aliaksei Pustavoitau, Benjamin Philosophe, Andrew M Cameron, Ahmet Gürakar
BACKGROUND/AIMS: Hepatitis B core antibody (HBcAb) positivity of the donor or the recipient may pose a risk of hepatitis B virus (HBV) reactivation following liver transplantation (LT). We retrospectively investigated patient survival and reactivation among recipients who were given low-dose Hepatitis B Immune Globulin (HBIG) plus antiviral agent (AV) versus AV only. MATERIALS AND METHODS: Records of cadaveric LT recipients, between 2013 and 2016, with positive Hepatitis B surface Antigen (HBsAg) and/or HBcAb and recipients who had received LT from HBcAb-positive donors were reviewed...
January 2018: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
https://www.readbyqxmd.com/read/29390565/lymphoepithelioma-like-hepatocellular-carcinoma-a-case-report-and-brief-review-of-literature
#9
Jun-Ke Wang, Yan-Wen Jin, Hai-Jie Hu, Parbatraj Regmi, Wen-Jie Ma, Qin Yang, Fei Liu, Cong-Dun Ran, Fei Su, Er-Liang Zheng, Fu-Yu Li
RATIONAL: Lymphoepithelioma-like hepatocellular carcinoma (LEL-HCC) is a rare variant of hepatocellular carcinoma (HCC). To date, few cases have been reported in the literature, and almost no report in analyzing the different features of LEL-HCC. PATIENT CONCERNS: We describe a 37-year-old female patient with a 32 × 30 mm mass in the right liver. INTERVENTIONS: Complete surgical resection of the lesion was performed. DIAGNOSES: Histopathological examination of the resected tumor revealed undifferentiated HCC cells with significant lymphocytes infiltration...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29388206/fraction-and-incidence-of-liver-cancer-attributable-to-hepatitis-b-and-c-viruses-worldwide
#10
Delphine Maucort-Boulch, Catherine de Martel, Silvia Franceschi, Martyn Plummer
High-quality data on liver cancers by probable cause are scarce in many regions of the world. The United Nations recently set a goal of eliminating viral hepatitis as a major public health threat by 2030. We aimed to estimate the number of new cases of cancers attributable to hepatitis B virus (HBV) and hepatitis C virus (HCV) at a global, regional and country level, and by development status. We used data on the prevalence of HBV and HCV in hepatocellular carcinoma from a systematic review including 119 000 cases in 260 studies covering 50 countries...
January 31, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29387314/trends-in-epidemiology-of-hepatitis-b-and-c-infections-in-ilam-province-national-notifiable-diseases-surveillance-system-data
#11
Salman Khazaei, Manoochehr Karami, Erfan Ayubi, Abolfazl Mohammadbeigi, Azim Hasanbeigi, Kamyar Mansori, Mohammad Reza Mir-Shekar
Background: Hepatitis B virus (HBV) and hepatitis C virus (HCV) infections are the main causes of severe liver failure worldwide. This study was conducted to evaluate the incidence rate and trend of these infections over six successive years from 2008 to 2013 in Ilam Province, western Iran. Methods: We studied the registered data of HBV and HCV based on the National Notifiable Diseases Surveillance System in Ilam Province from 2008 to 2013. Incidence rate per 100,000 populations was estimated for HBV and HCV infections through location, years and age groups of patients...
2018: Caspian Journal of Internal Medicine
https://www.readbyqxmd.com/read/29381084/characterization-of-scca-igm-as-a-biomarker-of-liver-disease-in-an-asian-cohort-of-patients
#12
Hoang Bui Huu, Nhuong Ha Thuc, Hoa Pham Thi Le, Thuy Do Thi Thanh, An Luong Bac, Claudio Tiribelli, Patrizia Pontisso, Andrea Gallotta, Laura Paneghetti, Giorgio Fassina
Viral hepatitis infection is a major global issue and a leading cause of liver disease and associated deaths. Over time, patients infected with hepatitis B (HBV) or C virus (HCV) develop cirrhosis and, eventually, hepatocellular carcinoma (HCC). For this reason, they need to be constantly monitored. Current Asian guidelines recommend the determination of serum alpha-fetoprotein (AFP) together with liver ultrasounds every six months to detect HCC nodules. However, both methods have several limitations, and other biomarkers have been studied for monitoring cirrhosis, including SCCA-IgM, an immune-complex formed by Squamous Cell Carcinoma Antigen and IgM...
January 30, 2018: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/29371017/hepatitis-b-virus-reactivation-during-direct-acting-antiviral-therapy-for-hepatitis-c-a-systematic-review-and-meta-analysis
#13
Marcus M Mücke, Lisa I Backus, Victoria T Mücke, Nicola Coppola, Carmen M Preda, Ming-Lun Yeh, Lydia S Y Tang, Pamela S Belperio, Eleanor M Wilson, Ming-Lung Yu, Stefan Zeuzem, Eva Herrmann, Johannes Vermehren
BACKGROUND: Direct-acting antiviral (DAA) therapy for chronic hepatitis C virus (HCV) infection might pose a risk for hepatitis B virus (HBV) reactivation in patients coinfected with chronic or resolved HBV infection. The need for HBV antiviral prophylaxis during DAA treatment remains controversial. We aimed to analyse the absolute risk of HBV reactivation in patients with active or resolved HBV infection treated with DAAs for HCV infection. METHODS: For this systematic review and meta-analysis, we searched PubMed, Ovid MEDLINE, the Cochrane Central Register of Controlled Trials, and Web of Science from Oct 1, 2010, to Sept 30, 2017, to identify studies of patients with chronic or resolved HBV infection at baseline treated with DAAs for chronic HCV infection...
January 19, 2018: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29353268/non-invasive-diagnostic-criteria-for-hepatocellular-carcinoma-in-hepatitis-b-virus-endemic-areas-is-cirrhosis-indispensable
#14
Xiao-Wen Huang, Bing Liao, Yang Huang, Jin-Yu Liang, Quan-Yuan Shan, Shun-Li Shen, Xiao-Yan Xie, Ming-de Lu, Li-da Chen, Wei Wang
AIM: To confirm whether cirrhosis is indispensable for the non-invasive diagnostic criteria for hepatocellular carcinoma (HCC) in hepatitis B virus (HBV)-endemic areas. METHODS: Between January 2014 and December 2014, a total of 409 patients with pathologically proven focal liver lesions who underwent contrast-enhanced ultrasound (CEUS) were recruited from our institution. Clinical liver cirrhosis, HBV/HCV infection and HCC-typical vascular pattern of the targeted lesion on CEUS were evaluated...
January 19, 2018: Digestive Diseases
https://www.readbyqxmd.com/read/29345515/safety-of-biologic-agents-for-psoriasis-in-patients-with-viral-hepatitis
#15
Nawaf AlMutairi, Hesham Alaadin Abouzaid
INTRODUCTION: Biologics are highly effective, important treatment options for moderate-to-severe psoriasis. Biologics are well tolerated and have few side effects. However, the use of biologics in patients with concomitant chronic viral hepatitis is debatable. Recent reports have suggested a very low associated risk of reactivation of chronic hepatitis B (HBV) and C (HCB). OBJECTIVE: To evaluate the safety and effectiveness of biologics for moderate to severe psoriasis patients with concomitant chronic viral hepatitis...
January 18, 2018: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/29331069/cellular-membrane-trafficking-machineries-utilized-by-the-hepatitis-viruses
#16
REVIEW
Jun Inoue, Masashi Ninomiya, Tooru Shimosegawa, Mark A McNiven
While the life cycles of hepatitis viruses (hepatitis A, B, C, D, and E viruses) have been modestly characterized, recent intensive studies have provided new insights. Because these viruses 'hijack' the membrane trafficking of the host cell machinery during replicative propagation, it is essential to determine and understand these specific cellular pathways. Hepatitis B virus (HBV) and hepatitis C virus (HCV) are well known as a leading cause of liver cirrhosis and hepatocellular carcinoma. While substantial inroads toward treating HCV patients have recently been made, patients with HBV continue to require life-long treatment, which makes a thorough understanding of the HBV life cycle essential...
January 13, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29324587/linkage-to-care-of-hbsag-positive-and-anti-hcv-positive-patients-after-a-systematic-screening-approach-in-the-german-primary-care-setting
#17
Anja Lüllau, David Petroff, Olaf Bätz, Jan Kramer, Katrin Jedrysiak, Hannelore Tenckhoff, Thomas Berg, Ingmar Wolffram, Johannes Wiegand
BACKGROUND: Identification of previously unknown cases is important to lower the burden of chronic hepatitis B and C infection. However, a screening program in the primary care setting has not yet been established. Therefore, a systematic screening project was conducted in 21 008 patients (Wolffram and colleagues). Here, we describe linkage to care of identified HbsAg-positive and anti-hepatitis C virus (HCV)-positive patients. METHODS: General practitioners characterized further medical care by a standardized questionnaire...
January 10, 2018: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29322398/hepatitis-c-virus-infection-and-development-of-type-2-diabetes-mellitus-systematic-review-and-meta-analysis-of-the-literature
#18
REVIEW
Silvia Fabiani, Poupak Fallahi, Silvia Martina Ferrari, Mario Miccoli, Alessandro Antonelli
Type 2 diabetes mellitus (T2DM) is an endocrine disorder encompassing multifactorial mechanisms, and chronic hepatitis C virus infection (CHC) is a multifaceted disorder, associated with extrahepatic manifestations, including endocrinological disorders. CHC and T2DM are associated, but the subject remains controversial. We performed a systematic review and meta-analysis evaluating such association, searching on PubMed until February 29, 2016. Inclusion criteria were: 1) presence of at least one internal control group age- and gender-matched (non-hepatopathic controls; and/or hepatopathic, not HCV-positive, controls); 2) sufficient data to calculate odds ratio and relative risk...
January 11, 2018: Reviews in Endocrine & Metabolic Disorders
https://www.readbyqxmd.com/read/29299894/human-immunodeficiency-virus-hiv-and-hepatitis-virus-coinfection-among-hiv-infected-korean-patients-the-korea-hiv-aids-cohort-study
#19
Yong Chan Kim, Jin Young Ahn, June Myung Kim, Youn Jeong Kim, Dae Won Park, Young Kyung Yoon, Joon Young Song, Shin Woo Kim, Jin Soo Lee, Bo Youl Choi, Yun Su Choi, Ju Yeon Choi, Myung Guk Han, Chun Kang, Jun Yong Choi
BACKGROUND: Despite declines in mortality and morbidity rates of patients with human immunodeficiency virus (HIV) infection as the result of highly active antiretroviral therapy, liver diseases due to chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infections are a leading cause of death among HIV-infected patients. However, HIV and HBV or HCV coinfection is still poorly documented, and more information is needed to better understand the characteristics of HIV-infected patients in Korea...
December 2017: Infection & Chemotherapy
https://www.readbyqxmd.com/read/29286012/hepatitis-a-b-c-and-hiv-seroprevalence-among-syrian-refugee-children-admitted-to-outpatient-clinics
#20
Şükran Köse, Ilker Ödemiş, Didem Çelik, Bengü Gireniz Tatar, Ilkay Akbulut, Dilek Yilmaz Çiftdoğan
Viral hepatitis is the most common cause of serious health problems such as liver cirrhosis and hepatocellular carcinoma (HCC). Leading to immunodeficiency disorders through different mechanisms, Human Immunodeficiency Virus (HIV) causes the development of severe secondary infections. Hepatitis A (HAV) is thought to spread by the faecal-oral route, while Hepatitis B (HBV), Hepatitis C (HCV) and HIV are mostly transmitted vertically during childhood. In our study, we aimed to determine the seroprevalence of HAV, HBV, HCV and HIV among Syrian refugee children who were admitted to outpatient clinics...
December 1, 2017: Le Infezioni in Medicina
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