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https://www.readbyqxmd.com/read/28726868/raman-spectroscopy-for-cancer-detection-and-cancer-surgery-guidance-translation-to-the-clinics
#1
REVIEW
Inês P Santos, Elisa M Barroso, Tom C Bakker Schut, Peter J Caspers, Cornelia G F van Lanschot, Da-Hye Choi, Martine F van der Kamp, Roeland W H Smits, Remco van Doorn, Rob M Verdijk, Vincent Noordhoek Hegt, Jan H von der Thüsen, Carolien H M van Deurzen, Linetta B Koppert, Geert J L H van Leenders, Patricia C Ewing-Graham, Helena C van Doorn, Clemens M F Dirven, Martijn B Busstra, Jose Hardillo, Aniel Sewnaik, Ivo Ten Hove, Hetty Mast, Dominiek A Monserez, Cees Meeuwis, Tamar Nijsten, Eppo B Wolvius, Robert J Baatenburg de Jong, Gerwin J Puppels, Senada Koljenović
Oncological applications of Raman spectroscopy have been contemplated, pursued, and developed at academic level for at least 25 years. Published studies aim to detect pre-malignant lesions, detect cancer in less invasive stages, reduce the number of unnecessary biopsies and guide surgery towards the complete removal of the tumour with adequate tumour resection margins. This review summarizes actual clinical needs in oncology that can be addressed by spontaneous Raman spectroscopy and it provides an overview over the results that have been published between 2007 and 2017...
July 20, 2017: Analyst
https://www.readbyqxmd.com/read/28725554/successful-surgical-management-of-new-onset-refractory-status-epilepticus-norse-presenting-with-gelastic-seizures-in-a-3%C3%A2-year-old-girl
#2
Ahmad Marashly, Sean Lew, Jennifer Koop
Gelastic seizures (GS) are typically associated with hypothalamic hamartomas and present during childhood. However it is now known that GS can be found in focal epilepsies arising from other regions in the brain, including mesial and neocortical frontal, temporal and parietal regions. GS have rarely been described as the presenting manifestation of New Onset Refractory Status Epilepticus (NORSE). In this article we describe a previously healthy 3-year-old who presented with an explosive onset of GS that were refractory to multiple anti-seizure medications...
2017: Epilepsy & Behavior Case Reports
https://www.readbyqxmd.com/read/28710894/short-frontal-plane-fractures-involving-the-dorsoproximal-articular-surface-of-the-proximal-phalanx-description-of-the-injury-and-a-technique-for-repair
#3
I M Wright, G Minshall
BACKGROUND: Chip fractures of the dorsoproximal articular margin of the proximal phalanx are common injuries in racehorses. Large fractures can extend distal to the joint capsule insertion and have been described as dorsal frontal fractures. OBJECTIVES: To report the location and morphology of short frontal plane fractures involving the dorsoproximal articular surface of the proximal phalanx and to describe a technique for repair under arthroscopic and radiographic guidance...
July 15, 2017: Equine Veterinary Journal
https://www.readbyqxmd.com/read/28694742/clinical-validation-of-a-blood-based-classifier-for-diagnostic-evaluation-of-asymptomatic-individuals-with-pulmonary-nodules
#4
Charles E Birse, Jennifer L Tomic, Harvey I Pass, William N Rom, Robert J Lagier
BACKGROUND: The number of pulmonary nodules detected in the US is expected to increase substantially following recent recommendations for nationwide CT-based lung cancer screening. Given the low specificity of CT screening, non-invasive adjuvant methods are needed to differentiate cancerous lesions from benign nodules to help avoid unnecessary invasive procedures in the asymptomatic population. We have constructed a serum-based multi-biomarker panel and assessed its clinical accuracy in a retrospective analysis of samples collected from participants with suspicious radiographic findings in the Prostate, Lung, Chest and Ovarian (PLCO) cancer screening trial...
2017: Clinical Proteomics
https://www.readbyqxmd.com/read/28692681/cervical-hpv-type-specific-pre-vaccination-prevalence-and-age-distribution-in-croatia
#5
Ivan Sabol, Nina Milutin Gašperov, Mihaela Matovina, Ksenija Božinović, Goran Grubišić, Ivan Fistonić, Dragan Belci, Laia Alemany, Sonja Džebro, Mara Dominis, Mario Šekerija, Sara Tous, Silvia de Sanjosé, Magdalena Grce
The main etiological factor of precancerous lesion and invasive cervical cancer are oncogenic human papillomaviruses types (HPVs). The objective of this study was to establish the distribution of the most common HPVs in different cervical lesions and cancer prior to the implementation of organized population-based cervical screening and HPV vaccination in Croatia. In this study, 4,432 cervical specimens, collected through a 16-year period, were tested for the presence of HPV-DNA by polymerase chain reaction (PCR) with three sets of broad-spectrum primers and type-specific primers for most common low-risk (LR) types (HPV-6, 11) and the most common high-risk (HR) types (HPV-16, 18, 31, 33, 45, 52, 58)...
2017: PloS One
https://www.readbyqxmd.com/read/28683126/can-we-differentiate-minimally-invasive-adenocarcinoma-and-non-invasive-neoplasms-based-on-high-resolution-computed-tomography-features-of-pure-ground-glass-nodules
#6
Xiaoye Wang, Lihua Wang, Weisheng Zhang, Hong Zhao, Feng Li
OBJECTIVE: The purpose of our study was to assess the differentially diagnostic value of radiographic characteristics of pure ground glass nodules (GGNs) between minimally invasive adenocarcinoma and non-invasive neoplasm. METHODS: Sixty-seven pure GGNs (28 minimally invasive adenocarcinomas (MIA) and 39 pre-invasive lesions) were analyzed from June 2012 to June 2015. Pre-invasive lesions consisted of 15 atypical adenomatous hyperplasia (AAH) and 24 adenocarcinomas in situ (AIS)...
2017: PloS One
https://www.readbyqxmd.com/read/28677745/galectin-1-is-a-diagnostic-marker-involved-in-thyroid-cancer-progression
#7
Vanessa Arcolia, Fabrice Journe, Aurore Wattier, Emmanuelle Leteurtre, Florence Renaud, Hans-Joachim Gabius, Myriam Remmelink, Christine Decaestecker, Alexandra Rodriguez, Sébastien Boutry, Sophie Laurent, Sven Saussez
Fine-needle aspiration (FNA) is the most commonly used pre-operative technique for diagnosis of malignant thyroid tumor. However, many benign lesions, with indeterminate diagnosis following FNA, are referred to surgery. Based on multifunctionality of the endogenous galectin-1, we aimed to assess its status for early diagnosis of thyroid cancer. Immunohistochemistry for galectin-1 and -3 was performed on a clinical series of 69 cases of thyroid lesions. Galectin-1 expression was further examined in two additional tissue microarrays (TMA) composed of 66 follicular adenomas and 66 papillary carcinomas in comparison to galectin-3 and cytokeratin-19 (CK19)...
July 4, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28675320/flow-cytometry-for-feline-lymphoma-a-retrospective-study-regarding-pre-analytical-factors-possibly-affecting-the-quality-of-samples
#8
Valeria Martini, Serena Bernardi, Priscilla Marelli, Marzia Cozzi, Stefano Comazzi
Objectives Flow cytometry (FC) is becoming increasingly popular among veterinary oncologists for the diagnosis of lymphoma or leukaemia. It is accurate, fast and minimally invasive. Several studies on FC have been carried out in canine oncology and applied with great results, whereas there is limited knowledge and use of this technique in feline patients. This is mainly owing to the high prevalence of intra-abdominal lymphomas in this species and the associated difficulty in the diagnostic procedures needed to collect the sample...
July 1, 2017: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/28669173/flow-cytometric-analysis-of-dna-ploidy-in-liquid-based-cytology-for-cervical-pre-cancer-and-cancer
#9
Sridhar Mishra, Namrata P Awasthi, Nuzhat Husain, Akansha Anand, Yashodhara Pradeep, Roohi Ansari, Sarita Saxena
Background: DNA ploidy analysis of cervical intraepithelial neoplasia (CIN) and invasive cervical cancer samples by flow cytometry (FCM) has been established as an aid to prognostic assessment. Liquid based cytology (LBC) increases diagnostic specificity by using ancillary techniques that provide information beyond morphology. The present study was undertaken to assess DNA ploidy in LBC samples as an adjunct for early detection of cervical pre-cancer and cancer. Methods: DNA ploidy assessment was performed on LBC samples of 50 cases and 31 controls...
June 25, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28663003/postoperative-radiotherapy-after-dcis-useful-for-whom
#10
Per Karlsson
The number of patients with ductal carcinoma in situ (DCIS) increases with more widely used screening mammography programs. DCIS accounts for approximately 20% of all new breast cancer diagnoses in these programs and the natural course of this heterogeneous group of pre-invasive lesions is not fully known. Better definition of subgroups benefitting from radiotherapy and knowledge on the natural course of DCIS are important issues for the future management of DCIS. Four large randomized trials have studied the effects of postoperative radiotherapy after breast conserving surgery in patients with wider spectrum of DCIS and all of them have shown radiotherapy to halve the risk of ipsilateral events, however, without any significant effect on breast cancer mortality...
June 26, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/28607685/concurrent-braf-and-pten-mutations-in-melanoma-of-unknown-origin-presenting-as-a-breast-mass
#11
Emmanuel Agosto-Arroyo, Marilin Rosa, Alec Chau, Laila Khazai
BACKGROUND: Metastases represent a small percentage of the malignancies affecting the breast, and only 5% of melanomas originate from non-cutaneous sites. Multiple genetic aberrations have been associated with the development of melanocytic lesions, including BRAF V600E mutation. Mutations in PTEN gene have also been related to the pathogenesis of multiple malignancies. PURPOSE/METHOD: This is the case of a 28-year-old female who presented with a tender, palpable mass in the upper outer quadrant of the right breast...
2017: SAGE open medical case reports
https://www.readbyqxmd.com/read/28592326/the-genomic-road-to-invasion-examining-the-similarities-and-differences-in-the-genomes-of-associated-oral-pre-cancer-and-cancer-samples
#12
Henry M Wood, Catherine Daly, Rebecca Chalkley, Burcu Senguven, Lisa Ross, Philip Egan, Preetha Chengot, Jennifer Graham, Neeraj Sethi, Thian K Ong, Kenneth MacLennan, Pamela Rabbitts, Caroline Conway
BACKGROUND: It is frequently assumed that pre-invasive lesions are simpler precursors of cancer and will contain a limited subset of the genomic changes seen in their associated invasive disease. Driver mutations are thought to occur early, but it is not known how many of these are present in pre-invasive lesions. These assumptions need to be tested with the increasing focus on both personalised cancer treatments and early detection methodologies. METHODS: We examined genomic copy number changes in 256 pre-invasive and invasive samples from 69 oral cancer patients...
June 7, 2017: Genome Medicine
https://www.readbyqxmd.com/read/28582957/a-case-of-organizing-hematoma-in-a-maxillary-sinus-after-reconstruction-of-a-blow-out-fracture
#13
Sang Hee An, Hyoung Min Park, Il Gyu Kang, Joo Hyun Jung
A 36-year-old man presented because of nasal obstruction, rhinorrhea, and postnasal drip. The patient had undergone reconstruction of a blow-out fracture of the orbital floor 12 years before and had sinusitis that likely had resulted from implant migration into the maxillary sinus. The inflammation was successfully resolved, and the implant was removed through a minimally invasive endoscopic sinus surgery technique. On pathologic examination, an organizing hematoma was identified as the cause of the lesion...
June 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28572614/early-detection-and-serial-monitoring-of-anthracycline-induced-cardiotoxicity-using-t1-mapping-cardiac-magnetic-resonance-imaging-an-animal-study
#14
Yoo Jin Hong, Heae Surng Park, Jeffrey Kihyun Park, Kyunghwa Han, Chul Hwan Park, Tai Kyung Kim, Sae Jong Yoo, Ji Yeon Lee, Pan Ki Kim, Jin Hur, Hye-Jeong Lee, Young Jin Kim, Young Joo Suh, Mun Young Paek, Byoung Wook Choi
A reliable, non-invasive diagnostic method is needed for early detection and serial monitoring of cardiotoxicity, a well-known side effect of chemotherapy. This study aimed to assess the feasibility of T1-mapping cardiac magnetic resonance imaging (CMR) for evaluating subclinical myocardial changes in a doxorubicin-induced cardiotoxicity rabbit model. Adult male New Zealand White rabbits were injected twice-weekly with doxorubicin and subjected to CMR on a clinical 3T MR system before and every 2-4 weeks post-drug administration...
June 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28557798/thermal-ablation-of-a-confluent-lesion-in-the-porcine-kidney-with-a-clinically-available-mr-hifu-system
#15
J M M van Breugel, M de Greef, J W Wijlemans, G Schubert, M A A J van den Bosch, C T W Moonen, M G Ries
The incidence of small renal masses (SRMs) sized  <4 cm has increased over the decades (as co-findings/or due to introduction of cross sectional imaging). Currently, partial nephrectomy (PN) or watchful waiting is advised in these patients. Ultimately, 80-90% of these SRMs require surgical treatment and PN is associated with a 15% complication rate. In this aging population, with possible comorbidities and poor health condition, both PN and watchful waiting are non-ideal treatment options. This resulted in an increased need for early, non-invasive treatment strategies such as MR-guided high intensity focused ultrasound (MR-HIFU)...
July 7, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28554668/anti-tumor-effects-of-a-human-mouse-cross-reactive-anti-adam17-antibody-in-a-pancreatic-cancer-model-in-vivo
#16
Jie Ye, Shun Ming Yuen, Gillian Murphy, Ruiyu Xie, Hang Fai Kwok
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal types of tumor amongst all human cancers due to late diagnosis and resistant to treatment with chemotherapy and radiation. Preclinical and clinical studies have revealed that ErbB family for example epidermal growth factor receptor (EGFR) is a validated molecular target for pancreatic cancer prevention and therapy. The ErbB signaling cascade is regulated by a member of the ADAM (a disintegrin and metalloprotease) family, namely ADAM17, by enzymatic cleavage of precursor ligands into soluble cytokines and growth factors...
May 26, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28542297/rim-sign-and-histogram-analysis-of-apparent-diffusion-coefficient-values-on-diffusion-weighted-mri-in-triple-negative-breast-cancer-comparison-with-er-positive-subtype
#17
Yangsean Choi, Sung Hun Kim, In Kyung Youn, Bong Joo Kang, Woo-Chan Park, Ahwon Lee
PURPOSE: To investigate associations between the clinicopathologic features and MRI features of triple-negative breast cancer (TNBC) and ER-positive breast cancer (BC) via apparent diffusion coefficient (ADC) histogram analysis. MATERIALS AND METHODS: In this study, 221 breast cancer patients with pre-operative MRI performed from August 2009 to March 2015 were included in a retrospective analysis. All patients had a pathologically confirmed diagnosis of invasive carcinoma and were grouped into ER-positive (149) or triple-negative (72) subtypes...
2017: PloS One
https://www.readbyqxmd.com/read/28529749/chondroblastic-osteosarcoma-arising-in-the-maxilla-mimicking-the-radiographic-and-histological-characteristics-of-cemento-osseous-lesions-a-case-report
#18
Bin-Bin Li, Jian-Yun Zhang, Yan Gao
Osteosarcomas of the jaw are comparatively rare and represent only 2-10% of all osteosarcomas. We herein present a rare case of an osteosarcoma exhibiting the radiographic and histological characteristics of cemento-osseous lesions in the alveolar ridge of the maxilla. A 53-year-old male patient presented with the complaint of gradual swelling of the left maxilla over 4 years. Radiography revealed an ill-defined radioopaque mass, intimately associated with the apices of the involved teeth, without a periosteal reaction...
May 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28515797/circulating-nucleosomes-as-new-blood-based-biomarkers-for-detection-of-colorectal-cancer
#19
Jean-François Rahier, Anne Druez, Laurence Faugeras, Jean-Paul Martinet, Myriam Géhénot, Eléonore Josseaux, Marielle Herzog, Jake Micallef, Fabienne George, Monique Delos, Thierry De Ronde, Abdenor Badaoui, Lionel D'Hondt
BACKGROUND: Colonoscopy is currently widely accepted as the gold standard for detection of colorectal cancer (CRC) providing detection of up to 95% of pre-cancerous lesions during the procedure. However, certain limitations exist in most countries including cost and access to the procedure. Moreover, colonoscopy is an invasive technique with risk inherent to the endoscopic procedure. For this reason, alternative screening tests, in particular, fecal occult blood-based tests, have been widely adopted for frontline screening...
2017: Clinical Epigenetics
https://www.readbyqxmd.com/read/28508872/actin-stress-fiber-organization-promotes-cell-stiffening-and-proliferation-of-pre-invasive-breast-cancer-cells
#20
Sandra Tavares, André Filipe Vieira, Anna Verena Taubenberger, Margarida Araújo, Nuno Pimpao Martins, Catarina Brás-Pereira, António Polónia, Maik Herbig, Clara Barreto, Oliver Otto, Joana Cardoso, José B Pereira-Leal, Jochen Guck, Joana Paredes, Florence Janody
Studies of the role of actin in tumour progression have highlighted its key contribution in cell softening associated with cell invasion. Here, using a human breast cell line with conditional Src induction, we demonstrate that cells undergo a stiffening state prior to acquiring malignant features. This state is characterized by the transient accumulation of stress fibres and upregulation of Ena/VASP-like (EVL). EVL, in turn, organizes stress fibres leading to transient cell stiffening, ERK-dependent cell proliferation, as well as enhancement of Src activation and progression towards a fully transformed state...
May 16, 2017: Nature Communications
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