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https://www.readbyqxmd.com/read/28932538/the-value-of-delayed-phase-enhanced-imaging-in-malignant-pleural-mesothelioma
#1
Akash M Patel, Ian Berger, E Paul Wileyto, Urooj Khalid, Drew A Torigian, Arun C Nachiappan, Eduardo M Barbosa, Warren B Gefter, Maya Galperin-Aizenberg, Narainder K Gupta, Charles B Simone, Andrew R Haas, Evan W Alley, Sunil Singhal, Keith A Cengel, Sharyn I Katz
BACKGROUND: Cross-sectional imaging of malignant pleural mesothelioma (MPM) can underestimate the presence of local tumor invasion. Since accurate staging is vital optimal choice of therapy, techniques that optimize pleural imaging are needed. Here we estimate the optimal timing of MPM enhancement on magnetic resonance imaging (MRI). METHODS: All MPM patients with intravenous (IV) contrast enhanced staging MRI between 2000-2016 at our institution were retrospectively selected for image analysis...
August 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28932359/coronary-angiography-findings-in-cardiac-arrest-patients-with-non-diagnostic-post-resuscitation-electrocardiogram-a-comparison-of-shockable-and-non-shockable-initial-rhythms
#2
Pedro Martínez-Losas, Pablo Salinas, Carlos Ferrera, María Teresa Nogales-Romo, Francisco Noriega, María Del Trigo, Iván Javier Núñez-Gil, Luis Nombela-Franco, Nieves Gonzalo, Pilar Jiménez-Quevedo, Javier Escaned, Antonio Fernández-Ortiz, Carlos Macaya, Ana Viana-Tejedor
AIM: To investigate the impact of coronary artery disease in a cohort of patients resuscitated from cardiac arrest with non-diagnostic electrocardiogram. METHODS: From March 2004 to February 2016, 203 consecutive patients resuscitated from in or out-of-hospital sudden cardiac arrest and non-diagnostic post-resuscitation electrocardiogram (defined as ST segment elevation or pre-sumably new left bundle branch block) who underwent invasive coronary angiogram during hospitalization were included...
August 26, 2017: World Journal of Cardiology
https://www.readbyqxmd.com/read/28930821/sonographic-image-of-cervix-epithelioid-trophoblastic-tumor-coexisting-with-mucinous-adenocarcinoma-in-a-postmenopausal-woman-a-case-report
#3
Yi Zhu, Guo-Nan Zhang, Rui-Bo Zhang, Yu Shi, Deng-Feng Wang, Rong He
RATIONALE: Epithelioid trophoblastic tumor (ETT) is a distinctive but rare gestational trophoblastic neoplasia (GTN) composed of chorionic-type intermediate trophoblast cells. Approximately 50% ETT arose from the uterine cervix or lower uterine segment following a previous pregnancy with vaginal bleeding. With its unusual ability to simulate an invasive epithelioid neoplasm, ETT frequently poses a diagnostic challenge, especially involving the uterine cervix. PATIENT CONCERNS: We herein report the case of a 60-year-old female with persistent vaginal bleeding and middle-level elevation of serum human chorionic gonadotropin (hCG)...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28918603/tumor-markers-of-uterine-cervical-cancer-a-new-scenario-to-guide-surgical-practice
#4
REVIEW
Gaetano Valenti, Salvatore Giovanni Vitale, Alessandro Tropea, Antonio Biondi, Antonio Simone Laganà
Since the introduction of Pap smear screening, the incidence and mortality of cervical cancer (CC) have been reduced drastically in USA and in other western states. Nevertheless, CC still remains the main cause of death from gynecological cancer in developing countries where screening programs are scant or inexistent. This evidence highlights the efficacy of screening, and the wide use of Human Papilloma Viruses (HPV) vaccines in developed countries. More and more people are, consequentially, undergoing a screening procedure, usually combined with HPV DNA test, increasing the early diagnosis of intraepithelial HPV-related lesions...
September 16, 2017: Updates in Surgery
https://www.readbyqxmd.com/read/28915523/-biologic-reconstruction-of-full-sized-cartilage-defects-of-the-hip-a-guideline-from-the-dgou-group-clinical-tissue-regeneration-and-the-hip-committee-of-the-aga
#5
Stefan Fickert, Matthias Aurich, Dirk Albrecht, Peter Angele, Lorenz Büchler, Michael Dienst, Christoph Erggelet, Jürgen Fritz, Christoph Gebhart, Hans Gollwitzer, Moritz Kindler, Christoph Lampert, Henning Madry, Gregor Möckel, Phillip Niemeyer, Jörg Schröder, Christian Sobau, Gunter Spahn, Wolfgang Zinser, Stefan Landgraeber
Background Symptomatic pre-arthritic deformities such as femoroacetabular impingement (FAI) or hip dysplasia often lead to localised cartilage defects and subsequently to osteoarthritis. The present review of the working group "Clinical Tissue Regeneration" of the German Society of Orthopaedics and Trauma (DGOU) and the hip committee of the AGA (German speaking Society for Arthroscopy and Joint Surgery) provides an overview of current knowledge of the diagnosis and surgical treatment of cartilage defects, in order to infer appropriate therapy recommendations for the hip...
September 15, 2017: Zeitschrift Für Orthopädie und Unfallchirurgie
https://www.readbyqxmd.com/read/28892888/role-of-herbal-agents-tea-tree-oil-and-aloe-vera-as-cavity-disinfectant-adjuncts-in-minimally-invasive-dentistry-an-in-vivo-comparative-study
#6
Gaurav Patri, Aliva Sahu
INTRODUCTION: The prevention and control of caries necessitates the elimination of cariogenic bacteria and cavity disinfectants have proved to play a major role in achieving the goal. The use of phytotherapy is trending and many natural products have shown anti-microbial properties which can be used as cavity disinfectant in the field of dentistry. AIM: The aim of this study was to compare the efficacy of herbal antibacterial agents (Tea Tree Oil (TTO) and Aloe vera) with commercially available 2% chlorhexidine (CHX) as cavity disinfectant for use in minimally invasive dentistry...
July 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28883420/personalized-structural-image-analysis-in-patients-with-temporal-lobe-epilepsy
#7
Christian Rummel, Nedelina Slavova, Andrea Seiler, Eugenio Abela, Martinus Hauf, Yuliya Burren, Christian Weisstanner, Serge Vulliemoz, Margitta Seeck, Kaspar Schindler, Roland Wiest
Volumetric and morphometric studies have demonstrated structural abnormalities related to chronic epilepsies on a cohort- and population-based level. On a single-patient level, specific patterns of atrophy or cortical reorganization may be widespread and heterogeneous but represent potential targets for further personalized image analysis and surgical therapy. The goal of this study was to compare morphometric data analysis in 37 patients with temporal lobe epilepsies with expert-based image analysis, pre-informed by seizure semiology and ictal scalp EEG...
September 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28881741/crabp-ii-enhances-pancreatic-cancer-cell-migration-and-invasion-by-stabilizing-interleukin-8-expression
#8
Shuiliang Yu, Neetha Parameswaran, Ming Li, Yiwei Wang, Mark W Jackson, Huiping Liu, Wei Xin, Lan Zhou
Our previous study shows that cellular retinoic acid binding protein II (CRABP-II) is overexpressed in pancreatic ductal adenocarcinoma (PDAC) and pre-cancerous lesions, but not detected in normal pancreatic tissues. In this study, we show that deletion of CRABP-II in PDAC cells by CRISPR/Cas9 does not affect cancer cell proliferation, but decreases cell migration and invasion. Gene expression microarray analysis reveals that IL-8 is one of the top genes whose expression is down-regulated upon CRABP-II deletion, while expression of MMP-2 and MMP-14, two targets of IL-8 are also significantly down-regulated...
August 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28869177/correlation-of-18-f-fdg-uptake-on-pet-ct-with-ki67-immunohistochemistry-in-pre-treatment-epithelial-ovarian-cancer
#9
M Mayoral, P Paredes, A Saco, P Fusté, P Perlaza, A Tapias, A Fernandez-Martinez, L Vidal, J Ordi, J Pavia, S Martinez-Roman, F Lomeña
OBJECTIVE: Standardized uptake value (SUV) and volumetric parameters such as metabolic tumour volume (MTV) and total lesion glycolysis (TLG) from (18)F-FDG PET/CT are useful criteria for disease prognosis in pre-operative and post-treatment epithelial ovarian cancer (EOC). Ki67 is another prognostic biomarker in EOC, associated with tumour aggressiveness. The aim of this study is to evaluate the association between (18)F-FDG PET/CT measurements and Ki67 in pre-treatment EOC to determine if PET/CT parameters could non-invasively predict tumour aggressiveness...
August 28, 2017: Revista Española de Medicina Nuclear e Imagen Molecular
https://www.readbyqxmd.com/read/28868088/chondral-defects-of-the-glenohumeral-joint-long-term-outcome-after-microfracturing-of-the-shoulder
#10
Sophia M Hünnebeck, Petra Magosch, Peter Habermeyer, Markus Loew, Sven Lichtenberg
INTRODUCTION: An increasing number of young patients are diagnosed with chondral lesions. Minimally invasive surgical techniques are important in order to delay progression of the early stages of osteoarthritis and the need for total joint replacement. MATERIALS AND METHODS: Patients (n = 32) who had received microfracturing of the shoulder were retrospectively enrolled, of whom 5 had received shoulder replacements after a mean time of 47 months. Of these patients, 23 completed the Disabilities of the Arm, Shoulder and Hand (DASH) and Constant-Murley Scores in addition to an additional subjective questionnaire...
2017: Obere Extremität
https://www.readbyqxmd.com/read/28866449/fractional-flow-reserve-in-below-the-knee-arteries-with-critical-limb-ischemia-and-validation-against-gold-standard-morphologic-functional-measures-and-long-term-clinical-outcomes
#11
Zoltán Ruzsa, Szilárd Róna, Gábor G Tóth, Péter Sótonyi, Olivier F Bertrand, Balázs Nemes, Béla Merkely, Kálmán Hüttl
INTRODUCTION: The aim of this study was to assess the applicability of fractional flow reserve measurement (FFR) in below-the-knee (BTK) arteries and to evaluate its correlation with non-invasive functional parameters before and after angioplasty. METHODS: We enrolled 39 patients with severe BTK arterial lesions. Inclusion criteria were critical limb ischemia (Rutherford 4-6) and angiographically proven arterial stenosis of the distal lower limb (percent diameter stenosis ≥70%)...
July 18, 2017: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/28861337/clinical-neuroimaging-in-the-preterm-infant-diagnosis-and-prognosis
#12
REVIEW
Manuel Hinojosa-Rodríguez, Thalía Harmony, Cristina Carrillo-Prado, John Darrell Van Horn, Andrei Irimia, Carinna Torgerson, Zachary Jacokes
Perinatal care advances emerging over the past twenty years have helped to diminish the mortality and severe neurological morbidity of extremely and very preterm neonates (e.g., cystic Periventricular Leukomalacia [c-PVL] and Germinal Matrix Hemorrhage - Intraventricular Hemorrhage [GMH-IVH grade 3-4/4]; 22 to < 32 weeks of gestational age, GA). However, motor and/or cognitive disabilities associated with mild-to-moderate white and gray matter injury are frequently present in this population (e.g., non-cystic Periventricular Leukomalacia [non-cystic PVL], neuronal-axonal injury and GMH-IVH grade 1-2/4)...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28855635/highly-efficient-dna-free-gene-disruption-in-the-agricultural-pest-ceratitis-capitata-by-crispr-cas9-ribonucleoprotein-complexes
#13
Angela Meccariello, Simona Maria Monti, Alessandra Romanelli, Rita Colonna, Pasquale Primo, Maria Grazia Inghilterra, Giuseppe Del Corsano, Antonio Ramaglia, Giovanni Iazzetti, Antonia Chiarore, Francesco Patti, Svenia D Heinze, Marco Salvemini, Helen Lindsay, Elena Chiavacci, Alexa Burger, Mark D Robinson, Christian Mosimann, Daniel Bopp, Giuseppe Saccone
The Mediterranean fruitfly Ceratitis capitata (medfly) is an invasive agricultural pest of high economic impact and has become an emerging model for developing new genetic control strategies as an alternative to insecticides. Here, we report the successful adaptation of CRISPR-Cas9-based gene disruption in the medfly by injecting in vitro pre-assembled, solubilized Cas9 ribonucleoprotein complexes (RNPs) loaded with gene-specific single guide RNAs (sgRNA) into early embryos. When targeting the eye pigmentation gene white eye (we), a high rate of somatic mosaicism in surviving G0 adults was observed...
August 30, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28844125/stem-cell-therapy-for-avascular-necrosis-of-femoral-head-in-sickle-cell-disease-report-of-11-cases-and-review-of-literature
#14
Mir Sadat-Ali, Md Q Azam, Ezzat M Elshabouri, Ahmad M Tantawy, Sadananda Acharya
Background and Objective: Sickle cell disease (SCD) is quite common in eastern Saudi Arabia and Avascular necrosis of femoral head (ANFH) occurs in 30% of the young patients leading to early joint arthroplasty. This study was conducted to assess the benefits of injection of osteoblasts in the avascular lesions of the head of femur. Patients and Methods: A preset technique was used, 10 CC of bone marrow aspiration was performed under local anesthesia and aseptic technique...
August 31, 2017: International Journal of Stem Cells
https://www.readbyqxmd.com/read/28842226/frozen-section-can-sharpen-or-sand-off-the-surgeon-s-knife-two-case-illustrations-with-skull-base-meningioma-mimics
#15
Madhivanan Karthigeyan, Pravin Salunke, Kirti Gupta, Apinderpreet Singh, Rekhapalli Rajasekhar
OBJECTIVE / BACKGROUND: Lesions at skull base merit careful evaluation of imaging and meticulous preoperative planning. Their needless radical resection could add to surgical morbidity. Occasionally, dura-based inflammatory/ infectious lesions at this site radiologically mimic meningiomas, which are the commonly encountered entity at this site. Not all require excision; rather it could be harmful in few. CASE REPORT: We describe two patients with skull base lesions that apparently resembled a meningioma on imaging, while the frozen section in both cases was contrary to the pre-operative diagnosis with inflammatory lesion in the first and invasive aspergillosis in the second case...
August 22, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28840099/specific-dti-seeding-and-diffusivity-analysis-improve-the-quality-and-prognostic-value-of-tms-based-deterministic-dti-of-the-pyramidal-tract
#16
Tizian Rosenstock, Davide Giampiccolo, Heike Schneider, Sophia Jutta Runge, Ina Bährend, Peter Vajkoczy, Thomas Picht
OBJECT: Navigated transcranial magnetic stimulation (nTMS) combined with diffusion tensor imaging (DTI) is used preoperatively in patients with eloquent-located brain lesions and allows analyzing non-invasively the spatial relationship between the tumor and functional areas (e.g. the motor cortex and the corticospinal tract [CST]). In this study, we examined the diffusion parameters FA (fractional anisotropy) and ADC (apparent diffusion coefficient) within the CST in different locations and analyzed their interrater reliability and usefulness for predicting the patients' motor outcome with a precise approach of specific region of interest (ROI) seeding based on the color-coded FA-map...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28829664/risk-factors-for-post-transplant-death-in-donation-after-circulatory-death-liver-transplantation
#17
Song Liu, Ji Miao, Xiaolei Shi, Yafu Wu, Chunping Jiang, Xinhua Zhu, Xingyu Wu, Yitao Ding, Qingxiang Xu
PURPOSE: In spite of the increasing success of liver transplantation, there remains inevitable risk of postoperative complications, re-operations, and even death. Risk factors that correlate with post-transplant death have not been fully identified. MATERIALS AND METHODS: We performed a retrospective analysis of 65 adults that received donation after circulatory death liver transplantation. Binary logistic regression and Cox's proportional hazards regression were employed to identify risk factors that associate with postoperative death and the length of survival period...
August 22, 2017: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/28821892/routine-staging-using-chest-computed-tomography-in-workup-of-treatment-na%C3%A3-ve-hepatocellular-carcinoma-prior-to-locoregional-therapy-is-there-a-need
#18
Po Wey Leong, Uei Pua, Kian Soon Lim
INTRODUCTION: The lung is the most common site of distal metastasis in patients with hepatocellular carcinoma (HCC), as seen in more than half of patients with extrahepatic disease. The incidence of pulmonary metastasis in all patients with HCC, however, remains low (between 4.5% to 20%). Their presence, nevertheless, contraindicates curative locoregional therapies. The role of staging chest computed tomography (CT) before locoregional treatment is not well defined. This study aimed to assess the utility of pre-treatment chest CT prior to locoregional therapy...
July 2017: Annals of the Academy of Medicine, Singapore
https://www.readbyqxmd.com/read/28809039/juvenile-melanomas-western-australian-melanoma-advisory-service-experience
#19
Jie Xin Xu, Sharnice Koek, Samantha Lee, Mark Hanikeri, Mark Lee, Trevor Beer, Christobel Saunders
BACKGROUND/OBJECTIVES: Juvenile melanoma (before 20 years of age) is a rare condition with poorly defined risk factors. We describe features of juvenile melanoma in Western Australia over the last two decades. METHOD: A retrospective review of juvenile melanomas was conducted from prospectively maintained databases, reviewed for patients' characteristics, clinical information, histology, treatment, recurrence and survival data. RESULTS: Altogether 95 cases of juvenile melanoma were reported to the Western Australian Cancer Registry between 2000 and 2013...
August 15, 2017: Australasian Journal of Dermatology
https://www.readbyqxmd.com/read/28799121/3-t-multiparametric-mri-characteristics-of-prostate-cancer-patients-suspicious-for-biochemical-recurrence-after-primary-focal-cryosurgery-hemiablation
#20
Michael Kongnyuy, Daniel M Halpern, Corinne C Liu, Kaitlin E Kosinski, David J Habibian, Anthony T Corcoran, Aaron E Katz
INTRODUCTION: We aimed to report on multiparametric MRI (mpMRI) characteristics of post-primary focal cryosurgery (PFC) patients suspected of biochemical recurrence (BCR) by the Phoenix criteria. METHODS: We retrospectively reviewed all patients at our institution who had undergone PFC. Prostate-specific antigen nadir was determined using 2 or more post-PFC values. Suspicion of BCR was determined using the Phoenix criteria (nadir + 2 ng/ml). At the discretion of the physician, pre-and post-PFC 3-T mpMRIs were obtained and in a few cases biopsies were performed...
August 10, 2017: International Urology and Nephrology
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