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https://www.readbyqxmd.com/read/28804676/guide-to-the-design-and-application-of-online-questionnaire-surveys
#1
Pramod R Regmi, Elizabeth Waithaka, Anjana Paudyal, Padam Simkhada, Edwin van Teijlingen
Collecting research data through traditional approaches (face-to-face, postal or telephone survey) can be costly and time consuming. The emerging data collection approach based on internet/e-based technologies (e.g. online platforms and email), is a relatively cost effective survey alternative. These novel data collection strategies can collect large amounts of data from participants in a short time frame. Similarly, they also seem to be feasible and effective in collecting data on sensitive issues or with samples they are generally hard to reach, for example, men who have sex with men (MSM) or migrants...
December 2016: Nepal journal of epidemiology
https://www.readbyqxmd.com/read/28770126/anorectal-malformations-histomorphological-and-immunohistochemical-evaluation-of-neuronal-dysfunction
#2
Yashika Bhatia, Sunita Singh, Kamal Nain Rattan, Padam Parmar, Divya Sahni, Rajeev Sen
OBJECTIVE: The patients with anorectal malformations (ARM) have been identified with specific and non-specific pathological changes. The present study was conducted with the aim to study histomorphological changes and various immunohistochemical (IHC) markers (calretinin, S-100, CD117) in intestinal wall specimens to assess neuronal dysfunction in ARM patients. MATERIAL AND METHODS: Thirty children having ARM were included in our study. In all the cases, a representative biopsy was received...
April 2017: Journal of Neonatal Surgery
https://www.readbyqxmd.com/read/28746354/spatio-temporal-epidemiology-of-japanese-encephalitis-in-nepal-2007-2015
#3
Dhan Kumar Pant, Tenzin Tenzin, Rakesh Chand, Barun Kumar Sharma, Padam Raj Bist
Japanese encephalitis (JE) is a major public health problem in Nepal. For the effective management and surveillance of JE, a clear understanding of its epidemiology is essential. Therefore, we conducted descriptive and spatial analyses to understand the spatio-temporal distribution of JE in human in Nepal. From 2007 to 2015, 1,823 JE cases were reported with a cumulative mean incidence of 0.735/100,000 population and a case fatality rate of 6.6%. The death rate in the up-to-24 years of age group was 74%. The JE cases were most commonly reported in the age group of 1-14 years...
2017: PloS One
https://www.readbyqxmd.com/read/28664619/heartwood-extract-from-dalbergia-sissoo-promotes-fracture-healing-and-its-application-in-ovariectomy-induced-osteoporotic-rats
#4
Anirudha Karvande, Vikram Khedgikar, Priyanka Kushwaha, Naseer Ahmad, Priyanka Kothari, Ashwni Verma, Padam Kumar, Geet Kumar Nagar, Prabhat Ranjan Mishra, Rakesh Maurya, Ritu Trivedi
OBJECTIVES: This study was undertaken to investigate the effects of a heartwood ethanolic extract (HEE) made from the Dalbergia sissoo on facture healing and in the prevention of pathological bone loss resulting from estrogen deficiency in ovariectomized (Ovx) rats. METHODS: Heartwood ethanolic extract (250, 500 and 1000 mg/kg per day) was administered orally immediately next day after drill-hole injury and continued for 2 weeks. Ovx rats received HEE at same doses for 12 weeks and compared with 17-β estradiol (E2; 100 μg/kg for 5 days/week subcutaneously) group...
June 30, 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/28645002/synthesis-of-s-linked-trisaccharide-glycal-of-derhodinosylurdamycin-a-discovery-of-alkyl-thiocyanate-as-an-efficient-electrophile-for-stereoselective-sulfenylation-of-2-deoxy-glycosyl-lithium
#5
Padam P Acharya, Kedar N Baryal, Cristin E Reno, Jianglong Zhu
Stereoselective synthesis of S-linked trisaccharide glycal of angucycline antitumor antibiotic derhodinosylurdamycin A is described. The synthesis has been accomplished employing our previously reported umpolung S-glycosylation strategy - stereoselective sulfenylation of 2-deoxy glycosyl lithium. It was found that sugar-derived thiocyanate was a better electrophile than corresponding asymmetric disulfide in this type of stereoselective sulfenylation.
June 15, 2017: Carbohydrate Research
https://www.readbyqxmd.com/read/28536683/disseminated-invasive-aspergillosis-in-a-prolonged-stay-in-the-intensive-care-unit
#6
Gajender Singh, Sonu Kalyan, Sant Prakash Kataria, Jyoti Sharma, Padam Parmar, Meenu Gilotra, Rajeev Sen
Aspergillus is a common cause of invasive mycosis, especially in immunocompromised individuals. We report the case of a 62-year-old male who was hospitalized after suffering severe physical injuries and died after few weeks of hospitalization. A medicolegal autopsy was conducted, and various organs were sent for histopathological examination of which heart, lungs, and kidneys showed extensive involvement by aspergillus. Thus, a diagnosis of disseminated invasive aspergillosis was made on autopsy, which itself is a rare entity...
January 2017: Autopsy & case reports
https://www.readbyqxmd.com/read/28426117/identifying-the-gaps-in-nepalese-migrant-workers-health-and-well-being-a-review-of-the-literature
#7
Padam P Simkhada, Pramod R Regmi, Edwin van Teijlingen, Nirmal Aryal
Background: The health and well-being of migrant workers from low-income countries is often neglected in travel medicine. This article uses Nepal as a case study to highlight key issues affecting this particular group of international travellers. Methods: This narrative review used a comprehensive systematic literature search to identify relevant studies on Nepal. The included articles were thematically analysed leading to four key themes or risk factors. Results: The search found 18 articles from which we identified 3 key themes related directly to migrant workers: (1) sexual risk taking; (2) occupational health and (3) lifestyles, and a fourth theme related to partners and family of migrant workers who are left behind in Nepal...
July 1, 2017: Journal of Travel Medicine
https://www.readbyqxmd.com/read/28274632/design-and-synthesis-of-dalbergin-analogues-and-evaluation-of-anti-osteoporotic-activity
#8
Padam Kumar, Priyanka Kushwaha, Naseer Ahmad, Saransh Wales Maurya, Kapil Dev, Vikram Khedgikar, Ibadur Rahman Siddiqui, Ritu Trivedi, Rakesh Maurya
The chemical modifications of the hydroxyl group of dalbergin have been described via the introduction of cyclic amine, ester and amide groups. Among the twenty-three prepared novel analogues of dalbergin, compound 4d (EC50 2.3μM) showed significantly increased proliferation as assessed by alkaline phosphatase activity and mineralization in calvarial osteoblast cells in vitro. Compound 4d, at a dose of 1.0mg/kg body weight exhibited the significant osteoprotective effect. It showed a significant increase in osteogenic gene expression RunX2 (∼4fold), ALP (∼5fold), OCN (∼4fold) and COL1 (∼4fold) as compared to control group at the same dose in vivo assay...
April 15, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28120479/urinary-haptoglobin-alpha-1-anti-chymotrypsin-and-retinol-binding-protein-identified-by-proteomics-as-potential-biomarkers-for-lupus-nephritis
#9
A Aggarwal, R Gupta, V S Negi, L Rajasekhar, R Misra, P Singh, V Chaturvedi, S Sinha
The study was aimed at identification by proteomics and validation by enzyme-linked immunosorbent assay (ELISA) of potential urinary biomarkers for lupus nephritis. Study subjects comprised 88 systemic lupus erythematosus (SLE) patients and 60 controls (rheumatoid arthritis, diabetes mellitus and healthy individuals). Based on the SLE disease activity index (SLEDAI), patients were classified as active renal (AR), active non-renal (ANR) or inactive disease (ID). Urinary proteins from a group of patients with AR or ID were resolved by two-dimensional gel electrophoresis and identified by matrix-assisted laser desorption ionization-time of flight-mass spectrometry (MALDI-TOF-MS/MS)...
May 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28118830/the-economic-burden-of-hiv-aids-on-individuals-and-households-in-nepal-a-quantitative-study
#10
Ak Narayan Poudel, David Newlands, Padam Simkhada
BACKGROUND: There have been only limited studies assessing the economic burden of HIV/AIDS in terms of direct costs, and there has been no published study related to productivity costs in Nepal. Therefore, this study explores in detail the economic burden of HIV/AIDS, including direct costs and productivity costs. This paper focuses on the direct costs of seeking treatment, productivity costs, and related factors affecting direct costs, and productivity costs. METHODS: This study was a cross-sectional, quantitative study...
January 24, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28050984/evaluation-of-bacteriological-profile-in-the-apical-root-segment-of-the-patients-with-primary-apical-periodontitis
#11
Aravind Tatikonda, N Sudheep, Krishna P Biswas, K Gowtham, Sudarshan Pujari, Padam Singh
INTRODUCTION: Apical periodontitis usually results from bacterial accumulation and contamination occurring in the root-canal system, and extending beyond the apical foramen to involve the periapical tissues. Literature has a paucity of the studies that stress on the division and analysis of the pulp canal segments. The reason for this disparity might be the technique used for collecting the samples from the pulp canals. Hence, we carried out the present study to evaluate the microbial flora in the apical part of the roots with necrotic pulp canals...
January 1, 2017: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/27936389/ethanolic-extract-of-dalbergia-sissoo-promotes-rapid-regeneration-of-cortical-bone-in-drill-hole-defect-model-of-rat
#12
Vikram Khedgikar, Priyanka Kushwaha, Naseer Ahmad, Jyoti Gautam, Padam Kumar, Rakesh Maurya, Ritu Trivedi
Leaves of Dalbergia sissoo is known to have protective actions against postmenopausal bone loss in rat. In this study, we have evaluated the fracture healing properties of ethanolic extract (EE) of Dalbergia sissoo leaves. To observe the fracture healing property in the drill-hole injury model, we randomly divided total 32 adult female Sprague Dawley rats (180±200g) into 4 groups: (i) Control operated group; (ii) EE (250mg/kg/day); (iii) EE (500mg/kg/day) and (iv) EE (1000mg/kg/day). The right femora were fractured at the mid-diaphysis region and each group of rats received their respective treatment for 15days...
February 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27911880/study-of-the-sign-change-of-exchange-bias-across-the-spin-reorientation-transition-in-co-cr1-x-fe-x-2o4-x%C3%A2-%C3%A2-%C3%A2-%C3%A2-0-00-0-125
#13
R Padam, Swati Pandya, S Ravi, S Ramakrishnan, A K Nigam, A K Grover, D Pal
We present the evolution of novel phenomena of magnetic compensation effect, exchange bias (EB) effect and the field induced anomalies in '[Formula: see text]' substituted multiferroic compound [Formula: see text]. A few percent of '[Formula: see text]' substitution for '[Formula: see text]' in [Formula: see text] results in the reversal of field cooled magnetization under low applied fields below compensation temperature T comp. Further, increase in the field leads to the spin reorientation transition (T SR)...
February 8, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/27871335/aldehyde-dehydrogenase-expression-in-metaphire-posthuma-as-a-bioindicator-to-monitor-heavy-metal-pollution-in-soil
#14
Raju Panday, Padam Shekhar Bhatt, Tribikram Bhattarai, Kumudini Shakya, Lakshmaiah Sreerama
BACKGROUND: Soil contamination and associated pollution plays a detrimental role in soil flora and fauna. Soil is processed and remodeled by subterranean earthworms, accordingly are referred to as soil chemical engineers. These worms, besides processing carbon and nitrogen, serve as minors for processing metals. In heavy metal contaminated soils, they accumulate heavy metals, which in turn cause altered gene expression, including aldehyde dehydrogenase (ALDH) enzymes. This study explores the possibility of ALDH expression in earthworms as a novel biomarker for the heavy metal contamination of soil...
November 21, 2016: BMC Research Notes
https://www.readbyqxmd.com/read/27717322/ergocalciferol-treatment-does-not-improve-erythropoietin-utilization-and-hospitalization-rate-in-hemodialysis-patients
#15
Gaurav Agarwal, Padam Hirachan, Jonathan Gelfond, Paolo Fanti, Claudia Hura, Shweta Bansal
BACKGROUND: Vitamin D (25-hydroxyvitamin D; 25[OH]D) deficiency (VDD) is highly prevalent in chronic kidney disease. The aim of this study was to evaluate the effect of oral ergocalciferol supplementation on requirement of erythropoietin (EPO) and active vitamin D analogues, and hospitalization rate in maintenance hemodialysis (HD) patients. METHODS: This retrospective cohort study included 186 patients who were on HD for 3 months and had 25(OH)D levels < 30 ng/ml...
October 7, 2016: BMC Nephrology
https://www.readbyqxmd.com/read/27687378/comparing-the-efficacy-and-safety-between-propofol-and-dexmedetomidine-for-sedation-in-claustrophobic-adults-undergoing-magnetic-resonance-imaging-padam-trial
#16
RANDOMIZED CONTROLLED TRIAL
Pui-San Loh, Mohd Azlan Ariffin, Vineya Rai, Lee-Lee Lai, Lucy Chan, Norlisah Ramli
STUDY OBJECTIVE: To determine the efficacy of sedation with dexmedetomidine compared to propofol for claustrophobic adults undergoing magnetic resonance imaging (MRI) in our institution. DESIGN: Randomized, prospective, double-blinded study. SETTING: University-based tertiary referral center. PATIENTS: Thirty claustrophobic adults with American Society of Anesthesiologists physical status I and II who were planned for MRI...
November 2016: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/27672582/neurenteric-cyst-presenting-with-bleeding-per-rectum
#17
Taruna Yadav, Padam Parmar, Kamal Nain Rattan
Neurenteric cyst in the thoracic cavity may produce a myriad of clinical features. We report a 7-month-old girl who presented with significant bleeding per rectum. On imaging, a mediastinal cystic structure with air-fluid levels was evident with cervico-thoracic vertebral anomalies. The cyst was excised and histopathology showed intestinal mucosal lining with heterotopic pancreatic tissue confirming the diagnosis of neurenteric cyst.
September 2016: APSP Journal of Case Reports
https://www.readbyqxmd.com/read/27634831/injury-and-mortality-in-young-nepalese-migrant-workers-a-call-for-public-health-action
#18
Nirmal Aryal, Pramod R Regmi, Edwin van Teijlingen, Padam Simkhada, Pratik Adhikary, Yadav Kumar Deo Bhatta, Stewart Mann
Approximately 3.5 million Nepalese are working as migrant workers in the Gulf countries, Malaysia, and India. Every year there are more than 1000 deaths and many hundreds cases of injuries among Nepalese workers in these countries excluding India. A postmortem examination of migrant workers is not carried out in most of these countries, and those with work-related injuries are often sent back to home. Uninsured migrant workers also do not have easy access to health care services in host countries due to the high medical and hospital fees...
November 2016: Asia-Pacific Journal of Public Health
https://www.readbyqxmd.com/read/27605797/rate-of-population-increase-of-poultry-shaft-louse-menopon-gallinae-in-vivo-condition
#19
Surendra Kumar, Padam Singh, Vijay Kumar
Attempts were made to determine the rate of expansion of Menopon gallinae by releasing 10 healthier looking adult lice on each of the twelve similar aged fowls and delousing two fowls fortnightly (up to 90 days). The experiments were performed in the months of summer as well as in the months of winter. It was found that an initial inoculum of 10 M. gallinae could produce 636 lice in summers (doubling time 15 days). During winter months 323 M. gallinae were recovered from an inoculum of 10 lice (doubling time 18 days)...
September 2016: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/27522257/fast-and-long-acting-neoflavonoids-dalbergin-isolated-from-dalbergia-sissoo-heartwood-is-osteoprotective-in-ovariectomized-model-of-osteoporosis-osteoprotective-effect-of-dalbergin
#20
Dharmendra Choudhary, Priyanka Kushwaha, Jyoti Gautam, Padam Kumar, Ashwani Verma, Avinash Kumar, Saransh Wales Maurya, Ibadur Rahman Siddiqui, Prabhat Ranjan Mishra, Rakesh Maurya, Ritu Trivedi
OBJECTIVE: This study aims to evaluate the skeletal effects of dalbergin (DBN), isolated from Dalbergia sissoo heartwood, in ovariectomized (OVx) BALB/c mice, a postmenopausal osteoporosis model of bone loss. METHODS: Adult BALB/c mice were used and randomly assigned in to six groups with 6 animals (n=6) in each group: sham (surgery operated without ovariectomy) with vehicle, ovariectomy with vehicle, ovariectomy (OVx) with estradiol (E2 5.0μgkg(-)1day(-1)), or ovariectomy with dalbergin at three different doses of DBN (1...
October 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
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