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Gaurav Agarwal, Padam Hirachan, Jonathan Gelfond, Paolo Fanti, Claudia Hura, Shweta Bansal
BACKGROUND: Vitamin D (25-hydroxyvitamin D; 25[OH]D) deficiency (VDD) is highly prevalent in chronic kidney disease. The aim of this study was to evaluate the effect of oral ergocalciferol supplementation on requirement of erythropoietin (EPO) and active vitamin D analogues, and hospitalization rate in maintenance hemodialysis (HD) patients. METHODS: This retrospective cohort study included 186 patients who were on HD for 3 months and had 25(OH)D levels < 30 ng/ml...
October 7, 2016: BMC Nephrology
Pui-San Loh, Mohd Azlan Ariffin, Vineya Rai, Lee-Lee Lai, Lucy Chan, Norlisah Ramli
STUDY OBJECTIVE: To determine the efficacy of sedation with dexmedetomidine compared to propofol for claustrophobic adults undergoing magnetic resonance imaging (MRI) in our institution. DESIGN: Randomized, prospective, double-blinded study. SETTING: University-based tertiary referral center. PATIENTS: Thirty claustrophobic adults with American Society of Anesthesiologists physical status I and II who were planned for MRI...
November 2016: Journal of Clinical Anesthesia
Taruna Yadav, Padam Parmar, Kamal Nain Rattan
Neurenteric cyst in the thoracic cavity may produce a myriad of clinical features. We report a 7-month-old girl who presented with significant bleeding per rectum. On imaging, a mediastinal cystic structure with air-fluid levels was evident with cervico-thoracic vertebral anomalies. The cyst was excised and histopathology showed intestinal mucosal lining with heterotopic pancreatic tissue confirming the diagnosis of neurenteric cyst.
September 2016: APSP Journal of Case Reports
Nirmal Aryal, Pramod R Regmi, Edwin van Teijlingen, Padam Simkhada, Pratik Adhikary, Yadav Kumar Deo Bhatta, Stewart Mann
Approximately 3.5 million Nepalese are working as migrant workers in the Gulf countries, Malaysia, and India. Every year there are more than 1000 deaths and many hundreds cases of injuries among Nepalese workers in these countries excluding India. A postmortem examination of migrant workers is not carried out in most of these countries, and those with work-related injuries are often sent back to home. Uninsured migrant workers also do not have easy access to health care services in host countries due to the high medical and hospital fees...
September 14, 2016: Asia-Pacific Journal of Public Health
Surendra Kumar, Padam Singh, Vijay Kumar
Attempts were made to determine the rate of expansion of Menopon gallinae by releasing 10 healthier looking adult lice on each of the twelve similar aged fowls and delousing two fowls fortnightly (up to 90 days). The experiments were performed in the months of summer as well as in the months of winter. It was found that an initial inoculum of 10 M. gallinae could produce 636 lice in summers (doubling time 15 days). During winter months 323 M. gallinae were recovered from an inoculum of 10 lice (doubling time 18 days)...
September 2016: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
Dharmendra Choudhary, Priyanka Kushwaha, Jyoti Gautam, Padam Kumar, Ashwani Verma, Avinash Kumar, Saransh Wales Maurya, Ibadur Rahman Siddiqui, Prabhat Ranjan Mishra, Rakesh Maurya, Ritu Trivedi
OBJECTIVE: This study aims to evaluate the skeletal effects of dalbergin (DBN), isolated from Dalbergia sissoo heartwood, in ovariectomized (OVx) BALB/c mice, a postmenopausal osteoporosis model of bone loss. METHODS: Adult BALB/c mice were used and randomly assigned in to six groups with 6 animals (n=6) in each group: sham (surgery operated without ovariectomy) with vehicle, ovariectomy with vehicle, ovariectomy (OVx) with estradiol (E2 5.0μgkg(-)1day(-1)), or ovariectomy with dalbergin at three different doses of DBN (1...
August 11, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Sheetal Sharma, Edwin van Teijlingen, Vanora Hundley, Catherine Angell, Padam Simkhada
BACKGROUND: Pregnancy and childbirth are socio-cultural events that carry varying meanings across different societies and cultures. These are often translated into social expectations of what a particular society expects women to do (or not to do) during pregnancy, birth and/or the postnatal period. This paper reports a study exploring beliefs around childbirth in Nepal, a low-income country with a largely Hindu population. The paper then sets these findings in the context of the wider global literature around issues such as periods where women are viewed as polluted (or dirty even) after childbirth...
2016: BMC Pregnancy and Childbirth
Priyanka Kushwaha, Vikram Khedgikar, Naseer Ahmad, Anirudha Karvande, Jyoti Gautam, Padam Kumar, Rakesh Maurya, Ritu Trivedi
Dalbergia sissoo Roxb. is a well known medicinal plant of India, enriched with various flavonoids used for treating multiple diseases. Earlier, we have shown that extract of Dalbergia sissoo Roxb. leaves mitigate ovariectomy induced bone loss and pure compounds (neoflavonoids) isolated from it, promote osteoblastogenesis in primary calvarial osteoblasts cells in vitro. Here, we hypothesize that dalsissooal (DSL), a novel neoflavonoid isolated from the heartwood of Dalbergia sissoo Roxb. is an important constituent of the extract that imparts bone forming effects...
October 5, 2016: European Journal of Pharmacology
Sheetal Sharma, Edwin van Teijlingen, José M Belizán, Vanora Hundley, Padam Simkhada, Elisa Sicuri
BACKGROUND: There is a need for studies evaluating maternal health interventions in low-income countries. This paper evaluates one such intervention designed to promote maternal health among rural women in Nepal. METHODS AND RESULTS: This was a five-year controlled, non-randomised, repeated cross-sectional study (2007, 2010, 2012) of a participatory community-based maternal health promotion intervention focusing on women's groups to improve maternal health services uptake...
2016: PloS One
Padam P Simkhada, Aditi Sharma, Edwin R van Teijlingen, Rachel L Beanland
BACKGROUND: Increased travel abroad has a significant impact on the incidence and prevalence of Sexually Transmitted Infections (STIs). Previous reviews have focused on the knowledge, attitudes and behaviour of tourists and acquisition of STIs. Less is known about the impact on tourism operators in countries visited by tourists. The aim of this review is to ascertain factors influencing sexual behaviour between workers in the tourism industry and tourists; exploring the prevalence of sexual behaviour between the two populations, their perceptions of sexual risk while engaging in sexual activities and the knowledge of tourism operators regarding STIs...
March 2016: Nepal journal of epidemiology
John Orechia, Ameet Pathak, Yunling Shi, Aniket Nawani, Andrey Belozerov, Caitlin Fontes, Camille Lakhiani, Chetan Jawale, Chetansharan Patel, Daniel Quinn, Dmitry Botvinnik, Eddie Mei, Elizabeth Cotter, James Byleckie, Mollie Ullman-Cullere, Padam Chhetri, Poornima Chalasani, Purushotham Karnam, Ronald Beaudoin, Sandeep Sahu, Yelena Belozerova, Jomol P Mathew
We live in the genomic era of medicine, where a patient's genomic/molecular data is becoming increasingly important for disease diagnosis, identification of targeted therapy, and risk assessment for adverse reactions. However, decoding the genomic test results and integrating it with clinical data for retrospective studies and cohort identification for prospective clinical trials is still a challenging task. In order to overcome these barriers, we developed an overarching enterprise informatics framework for translational research and personalized medicine called Synergistic Patient and Research Knowledge Systems (SPARKS) and a suite of tools called Oncology Data Retrieval Systems (OncDRS)...
September 2015: Applied & Translational Genomics
Padam Kumari Agarwal, Mustafa Ali, Ritu Ranjan, Ashutosh Pandey
Mixed gonadal dysgenesis (MGD) is a rare disorder of sexual development (DSD). A seven-year-old child with vagina and an elongated clitoris looking like a penile part of male external genitalia, presented in the Paediatric Surgery Department. Ultrasound of pelvis revealed a streak ovary on the right side and ovotestis on the left side. Uterus was not visualized. Karyotyping revealed 46, XY/45, XO genotype. Laparoscopic gonadectomy with vaginoplasty and the clitoral reduction was performed. A thorough histopathological examination of the specimen revealed structure of ovotestis-consisting of the ovary with Graafian follicles, fallopian tube, infantile testis with Leydig and Sertoli cells, epididymis, vas deference, and pampiniform plexus...
January 2016: Indian Journal of Pathology & Microbiology
Preeti K Mahato, Pramod R Regmi, Edwin van Teijlingen, Padam Simkhada, Catherine Angell, Brijesh Sathian
No abstract text is available yet for this article.
December 2015: Nepal journal of epidemiology
Padam Simkhada, Pramod R Regmi, Puspa Raj Pant, Edwin van Teijlingen, Brijesh Sathain
No abstract text is available yet for this article.
December 2015: Nepal journal of epidemiology
Edwin van Teijlingen, Padam Simkhada
On too many occasions researchers conduct public health and/or epidemiological studies in low-income countries without the appropriate in-country ethical approval. This article reflects on some of the underlying reasons for not applying for ethical approval. The piece concludes that we need to start by educating our (junior) researchers and research students about the importance of research ethics. We conclude with a number of recommendations for researchers, scientific journal editors and reviewers and ethical committees in high-income countries to bring the message home to researchers that ethical approval should be sought in low-income countries if and when required!...
September 2015: Nepal journal of epidemiology
Ak Narayan Poudel, David Newlands, Padam Simkhada
Thousands of people are infected with HIV/AIDS in Nepal and most of them are adults of working age. Therefore, HIV/AIDS is a big burden in Nepal. This review was conducted to find the existing knowledge gap about the economic burden of HIV/AIDS at the household level in Nepal, the extent of economic burden exerted by the disease, and to provide policy recommendations. It is concluded that there was a considerable knowledge gap about the issue, and the economic burden exerted by HIV/AIDS was big enough to push the affected households into poverty...
September 2015: Nepal journal of epidemiology
Edwin van Teijlingen, Padam Simkhada, Bhimsen Devkota, Padmadharini Fanning, Jillian Ireland, Bibha Simkhada, Lokendra Sherchan, Ram Chandra Silwal, Samridhi Pradhan, Shyam K Maharjan, Ram K Maharjan
No abstract text is available yet for this article.
September 2015: Nepal journal of epidemiology
Padam Simkhada, Edwin van Teijlingen, Puspa Raj Pant, Brijesh Sathian, Gangalal Tuladhar
No abstract text is available yet for this article.
June 2015: Nepal journal of epidemiology
P Padam, S Clark, W Irving, R Gellissen, E Thomson, J Main, G S Cooke
New direct-acting antivirals (DAA) for hepatitis C virus (HCV) infection have achieved high cure rates in many patient groups previously considered difficult-to-treat, including those HIV/HCV co-infected. The high price of these medications is likely to limit access to treatment, at least in the short term. Early treatment priority is likely to be given to those with advanced disease, but a more detailed understanding of the potential benefits in treating those with mild disease is needed. We hypothesized that successful HCV treatment within a co-infected population with mild liver disease would lead to a reduction in the use and costs of healthcare services in the 5 years following treatment completion...
February 2016: Journal of Viral Hepatitis
Yi Ren, Xiaoguang Yang, Yu Zhang, Ying Wang, Xuezhi Li
OBJECTIVES: Partial androgen deficiency of the aging male (PADAM) is characterised by a deficiency in serum androgen levels. Both electroacupuncture (EA) and mild moxibustion (MM) can raise serum testosterone levels in PADAM. We investigated the mechanisms underlying the use of EA and MM in a rodent model of PADAM. METHODS: Fifty rats received cyclophosphamide injection over 5 consecutive days to induce PADAM, which was verified by comparing total testosterone (TT) and free testosterone (FT) levels with 10 non-PADAM healthy control rats (CON)...
April 2016: Acupuncture in Medicine: Journal of the British Medical Acupuncture Society
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