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ADHD and (RON)

Dora Wynchank, Margreet Ten Have, Denise Bijlenga, Brenda W Penninx, Aartjan T Beekman, Femke Lamers, Ron de Graaf, J J Sandra Kooij
STUDY OBJECTIVES: Insomnia and short or long sleep duration are important comorbid conditions in adults with attention-deficit hyperactivity disorder (ADHD), but reports of the association vary. In a general population study, we evaluated the relationship between ADHD symptom severity, insomnia symptoms, and sleep duration in adults. METHODS: Data were from the third wave of the Netherlands Mental Health Survey and Incidence Study-2 (NEMESIS-2; n = 4,618). ADHD symptom severity and symptom dimensions (hyperactivity and inattention) were assessed using the Adult ADHD Self-Report Scale screener...
March 15, 2018: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
Suzan W N Vogel, Margreet L Ten Have, Denise Bijlenga, Ron de Graaf, Aartjan T F Beekman, J J Sandra Kooij
OBJECTIVE: This is the first study to examine self-reported seasonal differences in the severity of ADHD symptoms in adults from the general population. METHOD: Data were analyzed from N = 5,303 respondents participating in the second wave of the Netherlands Mental Health Survey and Incidence Study-2, a population-based study on mental health. ADHD symptoms were assessed using the Adult ADHD Self-Report Scale Screener. As indicators of the severity of ADHD symptoms, the total ADHD symptom score and inattention and hyperactivity subscale scores were examined...
May 19, 2016: Journal of Attention Disorders
L Oja, M Huotilainen, E Nikkanen, H Oksanen-Hennah, M Laasonen, A Voutilainen, L von Wendt, K Alho
Involuntary switching of attention to distracting sounds was studied by measuring effects of these events on auditory discrimination performance and event-related brain potentials (ERPs) in 6-11-year-old boys with Attention Deficit-Hyperactivity Disorder (ADHD) and comorbid Oppositional Defiant Disorder (ODD) and in age-matched controls. The children were instructed to differentiate between two animal calls by pressing one response button, for example, to a dog bark and another button to a cat mew. These task-relevant sounds were presented from one of two loudspeakers in front of the child, and there were occasional task-irrelevant changes in the sound location, that is, the loudspeaker...
February 1, 2016: Brain Research
A García Ron, R Serrano Grasa, R Blanco Lago, B Huete Hernani, D A Pérez Martinez
INTRODUCTION: Attention deficit hyperactivity disorder (ADHD) is the most frequent neurodevelopmental disorder and must be considered a public health priority because of its functional repercussions in school, family, and social settings. Health empowerment is an innovative model of care for patients with chronic diseases based on self-management education. Our goal is to evaluate the effectiveness of empowerment using coaching within a multimodal treatment plan in paediatric patients with ADHD...
March 2016: Neurología: Publicación Oficial de la Sociedad Española de Neurología
Ronald D Chervin, Susan S Ellenberg, Xiaoling Hou, Carole L Marcus, Susan L Garetz, Eliot S Katz, Elise K Hodges, Ron B Mitchell, Dwight T Jones, Raanan Arens, Raouf Amin, Susan Redline, Carol L Rosen
BACKGROUND: Adenotonsillectomy (AT) is commonly performed for childhood OSA syndrome (OSAS), but little is known about prognosis without treatment. METHODS: The Childhood Adenotonsillectomy Trial (CHAT) randomized 50% of eligible children with OSAS to a control arm (watchful waiting), with 7-month follow-up symptom inventories, physical examinations, and polysomnography. Polysomnographic and symptomatic resolution were defined respectively by an apnea/hypopnea index (AHI) <2 and obstructive apnea index (OAI) <1 and by an OSAS symptom score (Pediatric Sleep Questionnaire [PSQ]) < 0...
November 2015: Chest
Orly Ben-Or, Nathanel Zelnik, Ron Shaoul, Avi Pacht, Aaron Lerner
In recent years, there has been an increasing incidence of inflammatory bowel disease in children and adolescents. Neurologic involvement has been mainly reported in adults, and information in pediatrics is based primarily on individual case reports. In this study, we explored the prevalence and spectrum of neurologic manifestations of 50 children with inflammatory bowel disease in comparison to healthy controls. Based on clinical reports and neurologic evaluation, 34 patients (68%) exhibited neurologic manifestations compared with 10 children (23...
April 2015: Journal of Child Neurology
Ron Nudel, Nuala H Simpson, Gillian Baird, Anne O'Hare, Gina Conti-Ramsden, Patrick F Bolton, Elizabeth R Hennessy, Anthony P Monaco, Julian C Knight, Bruce Winney, Simon E Fisher, Dianne F Newbury
BACKGROUND: Human leukocyte antigen (HLA) loci have been implicated in several neurodevelopmental disorders in which language is affected. However, to date, no studies have investigated the possible involvement of HLA loci in specific language impairment (SLI), a disorder that is defined primarily upon unexpected language impairment. We report association analyses of single-nucleotide polymorphisms (SNPs) and HLA types in a cohort of individuals affected by language impairment. METHODS: We perform quantitative association analyses of three linguistic measures and case-control association analyses using both SNP data and imputed HLA types...
January 17, 2014: Journal of Neurodevelopmental Disorders
Boris Gramatikov, Kristina Irsch, Marie Müllenbroich, Nicole Frindt, Yinhong Qu, Ron Gutmark, Yi-Kai Wu, David Guyton
A device for continuous monitoring of central fixation utilizes birefringence, the property of the Henle fibers surrounding the human fovea, to change the polarization state of light. A circular scan of retinal birefringence, where the scanning circle encompasses the fovea, allows identification of true central fixation-an assessment much needed in various applications in ophthalmology, psychology, and psychiatry. The device allows continuous monitoring for central fixation over an extended period of time in the presence of fixation targets and distracting stimuli, which may be helpful in detecting attention deficit hyperactivity disorder, autism spectrum disorders, and other disorders characterized by changes in the subject's ability to maintain fixation...
September 2013: Annals of Biomedical Engineering
Miquel A Fullana, Gemma Vilagut, David Mataix-Cols, Núria Duran Adroher, Ronny Bruffaerts, Brendan Bunting, Jose M Caldas de Almeida, Silvia Florescu, Giovanni de Girolamo, Ron de Graaf, Josep M Haro, Viviane Kovess, Jordi Alonso
BACKGROUND: Although hoarding symptoms have been traditionally conceptualized as part of obsessive-compulsive disorder (OCD), recent data suggest that they may be more closely related to attention-deficit hyperactivity (ADHD) symptoms and, in particular, inattention. The aim of the present epidemiological study was to investigate the association between retrospectively reported ADHD symptoms in childhood and lifetime hoarding symptoms. METHODS: Retrospectively reported childhood ADHD, and lifetime hoarding and obsessive-compulsive symptoms were assessed with the Composite International Diagnostic Interview 3...
August 2013: Depression and Anxiety
Martin Poot, Annemarie A Verrijn Stuart, Emma van Daalen, Andries van Iperen, Ellen van Binsbergen, Ron Hochstenbach
Patients with trisomy or tetrasomy of distal 15q show a recognizable overgrowth syndrome, whereas patients with a monosomy of 15q26 share some degree of pre- and postnatal growth retardation, but differ with respect to facial and skeletal dysmorphisms, congenital heart disease and intellectual development. By reviewing 16 cases with losses of 15q26 we found that the size of the deletion was also not a predictor of the breadth of the phenotypic spectrum, the severity of disease or prognosis of the patient. Although monosomies of 15q26 do not represent a classical contiguous gene syndrome, a few candidate genes for selected features such as proportional growth retardation and cardiac abnormalities have been identified...
July 2013: European Journal of Medical Genetics
Ron de Graaf, Margreet ten Have, Marlous Tuithof, Saskia van Dorsselaer
BACKGROUND: Prospective studies measuring first-incidence of DSM-IV mood, anxiety and substance use disorders in the general population are rare. We assessed these incidence rates in the Dutch population; and identified baseline sociodemographic, physical and psychopathological variables, and negative changes in sociodemographics and physical health between baseline and follow-up, as determinants of first-onset main categories of disorders. METHOD: Data are from NEMESIS-2, a representative face-to-face survey including 5303 subjects aged 18-64 interviewed twice (2007-2009; 2010-2012) with the CIDI 3...
July 2013: Journal of Affective Disorders
J J Sandra Kooij, Michael Huss, Philip Asherson, Ron Akehurst, Kathleen Beusterien, Alexis French, Rahul Sasané, Paul Hodgkins
OBJECTIVE: Given high rates of comorbidity, lack of awareness and global acceptance, and varying guidelines for its management, adult ADHD may be an especially difficult condition to diagnose and treat. The objective of this review was to explore and characterize similarities and differences among comorbidities associated with adult ADHD. METHOD: A review of the literature over the past 10 years was performed using Ovid. RESULTS: A myriad of comorbid conditions such as impulse-control/personality, anxiety, mood, substance use, learning, and sleep disorders overlap with adult ADHD...
July 2012: Journal of Attention Disorders
Philip Asherson, Ron Akehurst, J J Sandra Kooij, Michael Huss, Kathleen Beusterien, Rahul Sasané, Shadi Gholizadeh, Paul Hodgkins
OBJECTIVE: To explore the literature focusing on cultural influences in the diagnosis of adult ADHD and respective societal burden. METHOD: A review of the literature over the past 10 years was performed using OVID. RESULTS: Although numerous articles focused on diagnosis and burden of adult ADHD, few focused on cultural factors influencing diagnosis. Like other mental health disorders, cultural and social perspectives contribute to our understanding of adult ADHD and may play a significant role in the diagnosis and varying acceptance of the condition...
July 2012: Journal of Attention Disorders
Marlous Tuithof, Margreet ten Have, Wim van den Brink, Wilma Vollebergh, Ron de Graaf
BACKGROUND: Much is unclear about the association between attention-deficit/hyperactivity disorder (ADHD) and alcohol use (disorder). Research on this subject is hindered by the role of conduct disorder (CD). We investigate whether (1) childhood ADHD is associated with higher prevalence and earlier onset of alcohol initiation, regular alcohol use and alcohol use disorder (AUD) (2) CD mediates or modifies this association. METHODS: Data were derived from the baseline assessment of the Netherlands Mental Health Survey and Incidence Study-2, a general population study...
June 1, 2012: Drug and Alcohol Dependence
François Laplante, Wayne G Brake, Sara L Chehab, Ron M Sullivan
Birth complications involving reduced oxygen to the fetus pose risks for neurodevelopmental disorders like schizophrenia and ADHD, which involve central dopamine (DA) dysfunction and also show gender differences in incidence or severity. Here, we examine possible sex differences in the long-term consequences of perinatal anoxia in the rat, on central DA systems and DA-mediated behaviour. As adults, sensorimotor gating (prepulse inhibition, PPI) was differentially affected by anoxia in males and females, tending to be impaired only in males...
January 6, 2012: Neuroscience Letters
Andrew Lloyd, Paul Hodgkins, Rahul Sasane, Ron Akehurst, Edmund J S Sonuga-Barke, Patrick Fitzgerald, Annabel Nixon, Haim Erder, John Brazier
BACKGROUND: Attempts to estimate the cost effectiveness of attention-deficit hyperactivity disorder (ADHD) treatments in the past have relied on classifying ADHD patients as responders or non-responders to treatment. Responder status has been associated with a small gain in health-related quality of life (HR-QOL) [or utility, as measured using the generic QOL measure EQ-5D] of 0.06 (on a scale from 0 being dead to 1.0 being full health). OBJECTIVES: The goal of the present study was to develop and validate several ADHD-related health states, and to estimate utility values measured amongst the general public for those states and to re-estimate utility values associated with responder status...
2011: Patient
Ron Langevin, Suzanne Curnoe
This study examines the best predictor of lifetime recidivism among Hare's psychopathy scores (PCL-R), attention deficit hyperactivity disorder (ADHD) diagnosis, and brain dysfunction measures in a sample of 1,695 adult male sexual, violent, and nonviolent offenders. Results indicated that most variables were associated with significantly more frequent recidivism. The best predictor of overall recidivism was the PCL-R, but more specifically, it was its items on criminal history that were associated with recidivism...
February 2011: International Journal of Offender Therapy and Comparative Criminology
Jaswinder K Ghuman, Michael G Aman, Luc Lecavalier, Mark A Riddle, Alan Gelenberg, Ron Wright, Sydney Rice, Harinder S Ghuman, Carolyn Fort
OBJECTIVE: The aim of this study was to investigate the short-term efficacy and safety of methylphenidate (MPH) to treat attention-deficit/hyperactivity disorder (ADHD) symptoms in an understudied population of preschoolers with pervasive developmental disorder (PDD) or intellectual disability (ID). METHODS: Fourteen preschoolers with developmental disorders (DD, n = 14; PDD, n = 12; ID, n = 2) underwent MPH titration in a single-blind manner followed by a 4-week double-blind crossover phase...
August 2009: Journal of Child and Adolescent Psychopharmacology
Jaswinder K Ghuman, Michael G Aman, Harinder S Ghuman, Thomas Reichenbacher, Alan Gelenberg, Ron Wright, Sydney Rice, Carolyn Fort
OBJECTIVE: The aim of this study was to report preliminary data regarding effectiveness and tolerability of atomoxetine in 3- to 5-year-old preschool children with attention-deficit/hyperactivity disorder (ADHD). METHODS: Nine boys and 3 girls (mean age = 5.0 +/- 0.72 years) diagnosed with ADHD were treated with atomoxetine in an open-label pilot study. Atomoxetine was gradually titrated to a maximum dose of 1.8 mg/kg per day. RESULTS: There was a significant effect of time from baseline to end point on the parent-rated hyperactivity/impulsivity Swanson Nolan and Pelham (SNAP-IV-HI) subscale ratings (F[9, 11] = 6...
April 2009: Journal of Child and Adolescent Psychopharmacology
Carmen Lara, John Fayyad, Ron de Graaf, Ronald C Kessler, Sergio Aguilar-Gaxiola, Matthias Angermeyer, Koen Demytteneare, Giovanni de Girolamo, Josep Maria Haro, Robert Jin, Elie G Karam, Jean-Pierre Lépine, Maria Elena Medina Mora, Johan Ormel, José Posada-Villa, Nancy Sampson
BACKGROUND: Although it is known that childhood attention-deficit/hyperactivity disorder (ADHD) often persists into adulthood, childhood predictors of this persistence have not been widely studied. METHODS: Childhood history of ADHD and adult ADHD were assessed in 10 countries in the World Health Organization World Mental Health Surveys. Logistic regression analysis was used to study associations of retrospectively reported childhood risk factors with adult persistence among the 629 adult respondents with childhood ADHD...
January 1, 2009: Biological Psychiatry
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