Ron Nudel, Michael E Benros, Morten Dybdahl Krebs, Rosa Lundbye Allesøe, Camilla Koldbæk Lemvigh, Jonas Bybjerg-Grauholm, Anders D Børglum, Mark J Daly, Merete Nordentoft, Ole Mors, David M Hougaard, Preben Bo Mortensen, Alfonso Buil, Thomas Werge, Simon Rasmussen, Wesley K Thompson
Human leukocyte antigen (HLA) genes encode proteins with important roles in the regulation of the immune system. Many studies have also implicated HLA genes in psychiatric and neurodevelopmental disorders. However, these studies usually focus on one disorder and/or on one HLA candidate gene, often with small samples. Here, we access a large dataset of 65,534 genotyped individuals consisting of controls (N = 19,645) and cases having one or more of autism spectrum disorder (N = 12,331), attention deficit hyperactivity disorder (N = 14,397), schizophrenia (N = 2401), bipolar disorder (N = 1391), depression (N = 18,511), anorexia (N = 2551) or intellectual disability (N = 3175)...
September 2019: European Journal of Human Genetics: EJHG