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https://www.readbyqxmd.com/read/28102052/increasing-incidence-of-invasive-and-in-situ-cervical-adenocarcinoma-in-the-netherlands-during-2004-2013
#1
Judith van der Horst, Albert G Siebers, Johan Bulten, Leon F Massuger, Inge McM de Kok
In the developed world, the incidence of cervical squamous cell carcinoma has decreased, however, the incidence of adenocarcinoma in situ (AIS) and invasive adenocarcinoma increased, predominantly in young females. The goal of this study was to evaluate the most recent incidence rates of AIS, adenocarcinoma, and squamous cell carcinoma of the uterine cervix in the Netherlands in 2004-2013. By using Dutch national pathology and cancer registries, we calculated European standardized incidence rates (ESR) and estimated annual percentage changes (EAPC) for AIS during 2004-2013 and for invasive cervical carcinomas during 1989-2013...
January 19, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28100595/determinants-of-viral-oncogenes-e6-e7-mrna-over-expression-in-a-population-based-large-sample-of-women-infected-by-high-risk-hpv-types
#2
Paolo Giorgi Rossi, Simonetta Bisanzi, Elena Allia, Alessandra Mongia, Francesca Carozzi, Anna Gillio-Tos, Laura De Marco, Guglielmo Ronco, Daniela Gustinucci, Annarosa Del Mistro, Helena Frayle, Anna Iossa, Giulia Fantacci, Giampaolo Pompei, Elena Cesarini, Simonetta Bulletti, Basilio Passamonti, Martina Rizzi, Maria Gabriella Penon, Alessandra Barca, Maria Benevolo
Cervical cancer screening by HPV-DNA testing with cytology triage is more effective than cytology testing. Compared to cytology, the HPV-DNA test higher sensitivity, that allows better protection with longer intervals, makes it necessary to triage the women with a positive result to compensate its lower specificity.We are conducting a large randomized clinical trial (New Technologies for Cervical Cancer 2, NTCC2) within organized population-based screening programs in Italy using HPV-DNA as primary screening test, to evaluate, by Aptima HPV Assay (Hologic), HPV E6-E7 mRNA as triage test in comparison to cytology...
January 18, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28097471/experiences-and-perceptions-regarding-clinical-breast-exam-screening-by-trained-laywomen-in-malawi
#3
Racquel E Kohler, Anna R Miller, Lily Gutnik, Clara N Lee, Satish Gopal
PURPOSE: Despite the increasing burden, breast cancer control in sub-Saharan Africa is insufficient. Late diagnosis and lack of early detection and screening services contribute to high mortality. Clinical breast exam (CBE) screening can be valuable in low-income countries, including use of community health workers and non-health professionals to conduct exams. We assessed experiences of women who underwent CBE screening by trained laywomen in Lilongwe, Malawi, as part of a pilot program...
January 17, 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28095411/optimal-management-strategies-for-primary-hpv-testing-for-cervical-screening-cost-effectiveness-evaluation-for-the-national-cervical-screening-program-in-australia
#4
Kate T Simms, Michaela Hall, Megan A Smith, Jie-Bin Lew, Suzanne Hughes, Susan Yuill, Ian Hammond, Marion Saville, Karen Canfell
BACKGROUND: Several countries are implementing a transition to HPV testing for cervical screening in response to the introduction of HPV vaccination and evidence indicating that HPV screening is more effective than cytology. In Australia, a 2017 transition from 2-yearly conventional cytology in 18-20 to 69 years to 5-yearly primary HPV screening in 25 to 74 years will involve partial genotyping for HPV 16/18 with direct referral to colposcopy for this higher risk group. The objective of this study was to determine the optimal management of women positive for other high-risk HPV types (not 16/18) ('OHR HPV')...
2017: PloS One
https://www.readbyqxmd.com/read/28094134/cervical-and-breast-cancer-screening-after-cares-a-community-program-for-immigrant-and-marginalized-women
#5
Sheila F Dunn, Aisha K Lofters, Ophira M Ginsburg, Christopher A Meaney, Farah Ahmad, M Catherine Moravac, Cam Tu Janet Nguyen, Angela M Arisz
INTRODUCTION: Marginalized populations such as immigrants and refugees are less likely to receive cancer screening. Cancer Awareness: Ready for Education and Screening (CARES), a multifaceted community-based program in Toronto, Canada, aimed to improve breast and cervical screening among marginalized women. This matched cohort study assessed the impact of CARES on cervical and mammography screening among under-screened/never screened (UNS) attendees. METHODS: Provincial administrative data collected from 1998 to 2014 and provided in 2015 were used to match CARES participants who were age eligible for screening to three controls matched for age, geography, and pre-education screening status...
January 13, 2017: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28056826/hpv-genotypes-distribution-in-indian-women-with-and-without-cervical-carcinoma-implication-for-hpv-vaccination-program-in-odisha-eastern-india
#6
Rashmirani Senapati, Bhagyalaxmi Nayak, Shantanu Kumar Kar, Bhagirathi Dwibedi
BACKGROUND: Considering the limited cross protection offered by the current HPV vaccines, understanding the HPV genotype distribution among the different population is essential in predicting the efficacy of current vaccine and devising new vaccine strategy. The present work aimed at investigating the HPV genotypes distribution among women with and without cervical carcinoma in Odisha, Eastern India. METHODS: A total of 607 participants have been enrolled between January 2014 and June 2016...
January 5, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28056279/-the-strategy-for-establishment-of-comprehensive-cervical-cancer-prevention-and-control-in-the-world
#7
H L Bao, L W Fang, L H Wang
Cervical cancer is one of the most common malignancies among women. Screening programs for cervical cancer have been implemented in many developed countries. Comprehensive systems for cervical cancer prevention and control have improved over the past 30 years, which has led to a significant decline in the morbidity and mortality of cervical cancer. Since 2009, the Chinese government has conducted the Cervical Cancer and Breast Cancer Screening Program for Rural Women on a national scale, which has substantially improved cervical cancer prevention and control...
January 6, 2017: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/28052819/disparities-in-cervical-cancer-incidence-and-mortality-can-epigenetics-contribute-to-eliminating-disparities
#8
R L Maguire, A C Vidal, S K Murphy, C Hoyo
Screening for uterine cervical intraepithelial neoplasia (CIN) followed by aggressive treatment has reduced invasive cervical cancer (ICC) incidence and mortality. However, ICC cases and carcinoma in situ (CIS) continue to be diagnosed annually in the United States, with minorities bearing the brunt of this burden. Because ICC peak incidence and mortality are 10-15 years earlier than other solid cancers, the number of potential years of life lost to this cancer is substantial. Screening for early signs of CIN is still the mainstay of many cervical cancer control programs...
2017: Advances in Cancer Research
https://www.readbyqxmd.com/read/28050595/cervical-cancer-prevention-training-in-south-east-asian-lmics
#9
Joseph Soon-Yau Ng, Ida Ismail-Pratt
The Association of Southeast Asian Nations (ASEAN) is a confederation of 10 sovereign states occupying approximately 1.7 million square miles of Southeast Asia with an estimated population of just under 630 million. Southeast Asia continues to have one of the world's highest rates of cervical cancer-related death. Organised training in cervical cancer screening is essential but lacking in low to middle income countries (LMICs). Systematic training of local doctors is an essential part of an effective screening program and an effective strategy to reduce cervical cancer-related mortality...
February 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/28027120/cervical-cancer-screening-of-adolescents-should-not-be-encouraged
#10
Laílca Quirino Henrique, Adriana Bittencourt Campaner, Flavia Salomão dʼAvila
OBJECTIVE: The study aims to assess the frequency of cytological abnormalities in adolescents and young women, to establish the optimum age to start screening. METHODS: A retrospective study of cervical cytology results were obtained from the data center at the Santa Casa Hospital of São Paulo between January 2006 and December 2014, adopting the Bethesda nomenclature system. The cytology exams were divided into 3 groups: group 1-adolescents (10-19 years old); group 2-young women (20-24 years old); and group 3-adults, comprising the remaining cytology exams...
January 2017: Journal of Lower Genital Tract Disease
https://www.readbyqxmd.com/read/28017434/cost-effectiveness-of-increasing-cervical-cancer-screening-coverage-in-the-middle-east-an-example-from-lebanon
#11
Monisha Sharma, Muhieddine Seoud, Jane J Kim
BACKGROUND: Most cervical cancer (CC) cases in Lebanon are detected at later stages and associated with high mortality. There is no national organized CC screening program so screening is opportunistic and limited to women who can pay out-of-pocket. Therefore, a small percentage of women receive repeated screenings while most are under-or never screened. We evaluated the cost-effectiveness of increasing screening coverage and extending intervals. METHODS: We used an individual-based Monte Carlo model simulating HPV and CC natural history and screening...
December 22, 2016: Vaccine
https://www.readbyqxmd.com/read/27988420/aptima-hpv-assay-versus-hybrid-capture-%C3%A2-2-hpv-test-for-primary-cervical-cancer-screening-in-the-hpv-focal-trial
#12
Darrel A Cook, Laurie W Smith, Jennifer Law, Wendy Mei, Dirk J van Niekerk, Kathy Ceballos, Lovedeep Gondara, Eduardo L Franco, Andrew J Coldman, Gina S Ogilvie, Dan Jang, Max Chernesky, Mel Krajden
BACKGROUND: Cervical cancer screening programs are switching from Pap screening to high-risk HPV testing. OBJECTIVES: To compare the Aptima HPV Assay (AHPV) with the Hybrid Capture(®) 2 High-Risk HPV DNA Test(®) (HC2) for primary cervical screening. STUDY DESIGN: HPV FOCAL is a randomized trial comparing HC2 to liquid-based cytology (LBC) for screening women aged 25-65. AHPV and HC2 were compared at the baseline screen (n=3473). Genotyping was by the Aptima HPV 16 18/45 Genotype Assay...
December 11, 2016: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/27975046/comparing-stage-of-diagnosis-of-cervical-cancer-at-presentation-in-immigrant-women-and-long-term-residents-of-ontario-a-retrospective-cohort-study
#13
Teja Voruganti, Rahim Moineddin, Nathaniel Jembere, Laurie Elit, Eva Grunfeld, Aisha K Lofters
BACKGROUND: Globally, cervical cancer is the fourth most common cancer in women and 7th most common cancer overall. Cervical cancer is highly preventable with screening. Previous work has shown that immigrants are less likely to undergo screening than nonimmigrants in Ontario, Canada. We examined whether immigrant women are more likely to present with later stage cervical cancer than long-term residents of the province. METHODS: We conducted a retrospective matched cohort study of women with cervical cancer diagnosed between 2010 and 2014 using provincial administrative health data...
July 2016: CMAJ Open
https://www.readbyqxmd.com/read/27935803/spatiotemporal-mapping-of-cervical-cancer-incidence-highlights-need-for-targeted-prevention-in-songkhla-province-thailand
#14
Jun Zhao, Shama Virani, Hutcha Sriplung
BACKGROUND: The national cervical cancer screening program in Thailand has been successful in reducing overall burden from this disease. However, evaluation on spatial and temporal scales is needed to assess the efficacy of this program in smaller regions. Here, we geographically assess incidence in a province with a uniquely heterogeneous distribution of lifestyle factors associated with religiosity. METHODS: Cervical cancer cases were extracted from the provincial cancer registry from 1989 to 2013...
October 25, 2016: Health Policy and Planning
https://www.readbyqxmd.com/read/27931835/management-of-patients-with-recurrent-advanced-cervical-cancer-beyond-first-line-platinum-regimens-where-do-we-stand-a-literature-review
#15
REVIEW
Stergios Boussios, Esmeralda Seraj, George Zarkavelis, Dimitrios Petrakis, Aristomenes Kollas, Aikaterini Kafantari, Abraam Assi, Konstantina Tatsi, Nicholas Pavlidis, George Pentheroudakis
BACKGROUND: Cervical cancer is the fourth most common cancer affecting women worldwide. Despite advances in screening and human papillomavirus (HPV) vaccination, a significant number of women present with or develop advanced disease. Palliative platinum-based chemotherapy (CT) is the standard first-line treatment for metastatic/recurrent cervical cancer. The prognosis remains poor and effective second line options are urgently needed. METHODS: We searched the English-language medical literature as well as relevant guideline databases, published from January 1981 to December 2015 and identified publications related to cervical cancer and its therapies...
December 2016: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/27926800/interobserver-reproducibility-of-cytologic-p16-ink4a-ki-67-dual-immunostaining-in-human-papillomavirus-positive-women
#16
Maria Benevolo, Elena Allia, Daniela Gustinucci, Francesca Rollo, Simonetta Bulletti, Elena Cesarini, Basilio Passamonti, Maria Rosaria Giovagnoli, Elisabetta Carico, Francesca M Carozzi, Alessandra Mongia, Giulia Fantacci, Massimo Confortini, Teresa Rubino, Cristina Fodero, Sonia Prandi, Natalina Marchi, Angelo Farruggio, Anna Coccia, Luigia Macrì, Bruno Ghiringhello, Guglielmo Ronco, Emma Bragantini, Enzo Polla, Vincenzo Maccallini, Giovanni Negri, Paolo Giorgi Rossi
BACKGROUND: The accumulation of cyclin-dependent kinase inhibitor 2A (p16(ink4a) ) protein in a cell is associated with neoplastic progression in precancerous cervical lesions. Dual staining for p16(ink4a) and Ki-67 has been proposed as a triage test in cervical cancer screening for women who test positive for human papillomavirus DNA. In this study, interobserver reproducibility of the interpretation of this test was assessed. METHODS: Forty-two immunostained, liquid-based cytology slides were divided into 2 sets and were interpreted by 17 to 21 readers from 9 different laboratories, yielding a total of 816 reports...
December 7, 2016: Cancer
https://www.readbyqxmd.com/read/27925175/to-expand-coverage-or-increase-frequency-quantifying-the-tradeoffs-between-equity-and-efficiency-facing-cervical-cancer-screening-programs-in-low-resource-settings
#17
Nicole G Campos, Vivien Tsu, Jose Jeronimo, Mercy Mvundura, Kyueun Lee, Jane J Kim
Cervical cancer is a leading cause of cancer death worldwide, with 85% of the disease burden residing in less developed regions. To inform evidence-based decision-making as cervical cancer screening programs are planned, implemented, and scaled in low- and middle-income countries, we used cost and test performance data from the START-UP demonstration project in Uganda and a microsimulation model of HPV infection and cervical carcinogenesis to quantify the health benefits, distributional equity, cost-effectiveness, and financial impact of either 1) improving access to cervical cancer screening or 2) increasing the number of lifetime screening opportunities for women who already have access...
December 7, 2016: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/27922905/scale-up-of-an-human-papillomavirus-testing-implementation-program-in-el-salvador
#18
Miriam Cremer, Mauricio Maza, Karla Alfaro, Mario Morales Velado, Juan Felix, Philip E Castle, Jane Kim, Julia C Gage
OBJECTIVE: The Cervical Cancer Prevention in El Salvador is a demonstration project to introduce a lower-cost human papillomavirus (HPV)-DNA test into a public sector project. Started in October 2012, The Cervical Cancer Prevention in El Salvador consists of 3 phases and will ultimately screen 30,000 women. Results of phase 2 of the project are presented. The objective of this project was to compare colposcopy and noncolposcopy-based management for HPV-positive women. MATERIAL AND METHODS: In phase 2, a total of 8,050 women, aged 30 to 49 years, were screened; 6,761 provided both self- and provider-collected specimens and 1,289 provided only provider-testing specimens...
January 2017: Journal of Lower Genital Tract Disease
https://www.readbyqxmd.com/read/27922769/see-test-treat-a-5-year-experience-of-pathologists-driving-cervical-and-breast-cancer-screening-to-underserved-and-underinsured-populations
#19
Barbarajean Magnani, Beth Harubin, Judith F Katz, Andrea L Zuckerman, William C Strohsnitter
CONTEXT: - See, Test & Treat is a pathologist-driven program to provide cervical and breast cancer screening to underserved and underinsured patient populations. This program is largely funded by the CAP Foundation (College of American Pathologists, Northfield, Illinois) and is a collaborative effort among several medical specialties united to address gaps in the current health care system. OBJECTIVE: - To provide an outline for administering a See, Test & Treat program, using an academic medical center as a model for providing care and collating the results of 5 years of data on the See, Test & Treat program's findings...
December 2016: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/27918650/clinical-value-of-fully-automated-p16-ki-67-dual-staining-in-the-triage-of-hpv-positive-women-in-the-norwegian-cervical-cancer-screening-program
#20
Irene T Ovestad, Ingvild Dalen, Elisabeth Hansen, Janne L D Loge, Britt Mona Dybdahl, Marius B Dirdal, Pia Moltu, Jannicke M Berland
BACKGROUND: More accurate biomarkers in cervical cytology screening could reduce the number of women unnecessarily referred for biopsy. This study investigated the ability of p16/Ki-67 dual staining to predict high-grade cervical intraepithelial neoplasia (CIN) in human papillomavirus (HPV)-positive women from the Norwegian Cervical Cancer Screening Program. METHODS: Automated p16/Ki-67 dual staining was performed on liquid-based cytology samples from 266 women who were HPV-positive at their secondary screening...
December 5, 2016: Cancer
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