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Baclofen cream

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https://www.readbyqxmd.com/read/27757050/new-topical-treatment-of-vulvodynia-based-on-the-pathogenetic-role-of-cross-talk-between-nociceptors-immunocompetent-cells-and-epithelial-cells
#1
J M Keppel Hesselink, D J Kopsky, N Sajben
Topical treatments of localized neuropathic pain syndromes in general are mostly neglected, mainly due to the fact that most pain physicians expect that a topical formulation needs to result in a transdermal delivery of the active compounds. On the basis of the practical experience, this study brings forth a new, somewhat neglected element of the vulvodynia pathogenesis: the cross talk between the nerve endings of nociceptors, the adjacent immunocompetent cells, and vaginal epithelial cells. Insight into this cross talk during a pathogenic condition supports the treatment of vulvodynia with topical (compounded) creams...
2016: Journal of Pain Research
https://www.readbyqxmd.com/read/26352120/retrospective-evaluation-on-the-analgesic-activities-of-2-compounded-topical-creams-and-voltaren-gel-in-chronic-noncancer-pain
#2
John C Somberg, Janos Molnar
Pharmacologic treatment of chronic pain is challenging. Oral therapy may require multiple medications; each has side effects, dose limitations, and limited efficacy. Compounded topical formulations have evolved as potential treatment options. The objective of this study was to evaluate the efficacy of 2 compounded topical creams, "Cream I" and "Cream II," in patients with chronic extremity, joint, musculoskeletal, neuropathic, or other chronic topical pain conditions and compare their efficacy with Voltaren gel...
September 2015: American Journal of Therapeutics
https://www.readbyqxmd.com/read/26290669/walking-with-neuropathic-pain-paradoxical-shift-from-burden-to-support
#3
David J Kopsky, Jan M Keppel Hesselink, Roberto Casale
Baclofen 5% cream can be used for the treatment of neuropathic pain. We describe an unusual case of a neuropathic pain patient with spinal cord injury. A 71-year-old woman with a partial spinal cord injury lesion at L4 complained of tingling, pins and needles, and burning in her legs. She scored her pain as 6 before adding baclofen 5% cream to her pain medication (pregabalin 450 mg, acetaminophen 3000 mg, and diclofenac 150 mg daily). One month later she experienced complete pain relief, though experienced increased difficulties in walking, leading to frequent falls...
2015: Case Reports in Medicine
https://www.readbyqxmd.com/read/25859821/retrospective-study-on-the-analgesic-activity-of-a-topical-tt-ctac-cream-in-patients-with-diabetic-neuropathy-and-other-chronic-pain-conditions
#4
John C Somberg, Janos Molnar
Treatment of chronic pain in diabetic neuropathy or neuropathic pain of other origins is challenging. Compounded topical formulations have evolved as potential treatment options. The objective of this retrospective study was to evaluate the efficacy of a compounded topical cream (Transdermal Therapeutics). Two versions of TT-CTAC cream were evaluated: cream 6B and cream 7B. Both creams contain ketamine (10%), baclofen (2%), gabapentin (6%), amitriptyline (4%), bupivacaine (2%), and clonidine (0.2%). Additionally, one cream (7B) contains nifedipine (2%)...
May 2015: American Journal of Therapeutics
https://www.readbyqxmd.com/read/24691823/vulvodynia-and-proctodynia-treated-with-topical-baclofen-5-and-palmitoylethanolamide
#5
Jan M Keppel Hesselink, David J Kopsky, Nancy L Sajben
BACKGROUND: The prevalence of idiopathic vulvodynia and proctodynia is high. Pain management with anti-depressants and anti-epileptics may induce undesirable side effects. Therefore, topical baclofen cream and palmitoylethanolamide might be new therapeutic options. CASE: A 33-year-old woman with intractable chronic vulvar and anal pain had to abstain from sexual intercourse and could neither cycle nor sit for more than 5 min. The patient did not respond to standard treatments...
August 2014: Archives of Gynecology and Obstetrics
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