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https://www.readbyqxmd.com/read/28437855/mild-fetal-cerebral-ventriculomegaly-prevalence-characteristics-and-utility-of-ancillary-testing-in-cases-presenting-to-a-tertiary-referral-center
#1
Alison J Mehlhorn, Cara E Morin, Jade J Wong-You-Cheong, Stephen A Contag
OBJECTIVE: Ventriculomegaly is the most common fetal brain anomaly identified during prenatal anatomy ultrasound. The aim of our study was to characterize cases of mild ventriculomegaly and investigate the utility of ancillary tests. METHOD: We reviewed 121 cases of mild ventriculomegaly, defined as lateral ventricle diameter of 10-15 mm. Characteristics of the ventricular dilation as well as each pregnancy were investigated. Ancillary tests performed included follow-up MRI, chromosomal abnormality testing, and maternal serologic infection screening...
April 24, 2017: Prenatal Diagnosis
https://www.readbyqxmd.com/read/28437803/prevalence-of-helicobacter-pylori-infection-among-blood-donors-in-saxony-anhalt-germany-a-region-at-intermediate-risk-for-gastric-cancer
#2
Caspar Franck, Armin Hoffmann, Alexander Link, Christian Schulz, Kerstin Wuttig, Elke Becker, Marcell Heim, Marino Venerito, Peter Malfertheiner
Background In the federal state of Saxony-Anhalt, gastric cancer (GC) incidence ranks among the highest in Germany. Helicobacter pylori prevalence is a surrogate marker for GC risk in a given population. In 2010 we reported an H. pylori seroprevalence of 44.4 % in patients at the emergency ward of the University Hospital of Magdeburg, the capital of Saxony-Anhalt. Our aim is to update these findings in a cohort of healthy blood donors from the same region. Materials and methods The sera of 516 consecutive blood donors (40...
April 24, 2017: Zeitschrift Für Gastroenterologie
https://www.readbyqxmd.com/read/28437465/serological-evidence-for-transmission-of-multiple-dengue-virus-serotypes-in-papua-new-guinea-and-west-papua-prior-to-1963
#3
Dagwin Luang-Suarkia, Timo Ernst, Michael P Alpers, Ralph Garruto, David Smith, Allison Imrie
Little is known about the natural history of dengue in Papua New Guinea (PNG). We assessed dengue virus (DENV)-specific neutralizing antibody profiles in serum samples collected from northern and southern coastal areas and the highland region of New Guinea between 1959 and 1963. Neutralizing antibodies were demonstrated in sera from the northern coast of New Guinea: from Sabron in Dutch New Guinea (now known as West Papua) and from four villages in East Sepik in what is now PNG. Previous monotypic infection with DENV-1, DENV-2, and DENV-4 was identified, with a predominance of anti-DENV-2 neutralizing antibody...
April 24, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28437323/lack-of-utility-of-anti-ttg-igg-to-diagnose-celiac-disease-when-anti-ttg-iga-is-negative
#4
Imad Absah, Abdul R Rishi, Rami Gebrail, Melissa R Snyder, Joseph A Murray
OBJECTIVES: Guidelines for diagnosing celiac disease (CD) recommend initial testing with a highly sensitive serologic test for anti-tissue transglutaminase immunoglobulin A antibodies (tTG IgA). When the probability of CD is high, IgA deficiency should be considered. The 2 approaches to address this include measuring "both tTG IgA and tTG IgG" or measuring "total IgA." We aim to assess the utility of an isolated positive tTG IgG result in diagnosing CD. METHODS: We conducted a retrospective review of patients undergoing serologic testing for CD from January 1997 to June 2014...
May 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28436254/the-correlation-between-histological-gastritis-staging-olga-olgim-and-serum-pepsinogen-test-in-assessment-of-gastric-atrophy-intestinal-metaplasia-in-china
#5
Xiaoteng Wang, Bin Lu, Lina Meng, Yihong Fan, Shuo Zhang, Meng Li
BACKGROUND: Serum pepsinogen (PG) test, as an indicator of gastric mucosal atrophy, reflects the functional and morphologic status of gastric mucosal and it is suggested to serve as a useful predictive marker for patients with gastric cancer (GC). The available classifications of gastritis, known as the Operative Link on Gastritis Assessment (OLGA) and Operative Link on Gastritis Intestinal Metaplasia (OLGIM), integrating the severity and topography of atrophy/intestinal metaplasia (IM), have been gradually accepted and used in screening for GC in recent years...
April 22, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/28435330/first-case-of-imported-chikungunya-infection-in-croatia-2016
#6
Boris Luksic, Nenad Pandak, Edita Drazic-Maras, Svjetlana Karabuva, Mislav Radic, Andrea Babic-Erceg, Ljubo Barbic, Vladimir Stevanovic, Tatjana Vilibic-Cavlek
In recent years, several European countries reported cases of imported chikungunya infection. We present the first imported clinically manifested chikungunya fever in Croatia. A 27-year-old woman returned to Croatia on 21 March 2016, after she stayed in Costa Rica for two months where she had noticed a mosquito bite on her left forearm. Five days after the mosquito bite she developed severe arthralgias, fever and erythematous papular rash. In next few days symptoms gradually subsided. After ten days she felt better, but arthralgias re-appeared accompanied with morning stiffness...
2017: International Medical Case Reports Journal
https://www.readbyqxmd.com/read/28435190/prevalence-of-salmonella-in-poultry-processing-environments-in-wet-markets-in-penang-and-perlis-malaysia
#7
Hafiz Nidaullah, Nadarajan Abirami, Ahamed Kamal Shamila-Syuhada, Li-Oon Chuah, Huda Nurul, Teik Pei Tan, Farah Wahida Zainal Abidin, Gulam Rusul
AIM: The aim of this study was to determine the prevalence of various Salmonella serotypes in chickens, carcass contact surfaces as well as environmental samples collected from wet markets and small scale processing plant. MATERIALS AND METHODS: A total of 182 poultry and environmental samples were collected at random on separate occasions from wet markets and small scale processing plant, during the period of October 2014 to July 2015 in Penang and Perlis, Malaysia...
March 2017: Veterinary World
https://www.readbyqxmd.com/read/28434966/diagnostic-biopsy-of-a-motor-branch-of-the-superficial-peroneal-nerve-to-the-peroneus-longus-a-convenient-alternative-for-motor-nerve-biopsy
#8
Randy S D'Amico, Christopher J Winfree
INTRODUCTION: Motor nerve biopsy is performed to supplement clinical, serological, and imaging data in the work-up of neuropathies of unknown origin, especially when motor neuron disease is suspected. METHODS: We describe a surgical technique for biopsy of a motor branch of the superficial peroneal nerve innervating the peroneus longus muscle. RESULTS: Three patients presented with weakness concerning for motor neuropathy and underwent biopsy of a motor branch of the superficial peroneal nerve innervating the peroneus longus muscle...
April 18, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28434776/a-patient-who-made-an-impact-on-how-i-practice-severe-leptospirosis-presenting-as-ards-in-the-icu
#9
Evangelia S Panagiotidou, Sofia V Akritidou, Seraphim T Kotoulas, Evdokia K Sourla, Basilis G Mpikos, Basilis P Bagalas, Ioannis T Stanopoulos, Katalin M Fekete, Athanasia D Pataka
Severe leptospirosis can be a rare cause of acute respiratory distress syndrome (ARDS) and multiorgan failure. A patient who made an impact on how I practice was a case of severe leptospirosis (Weil's disease) that presented as ARDS in the ICU. Leptospirosis is an under-reported infectious disease worldwide and should be considered as a cause of ARDS especially in patients with exposure history complicated with diffuse alveolar bleeding (DAH), icteric hepatitis and renal deterioration. Empiric treatment should be recommended before confirmation of laboratory tests as serological diagnosis is time consuming...
April 20, 2017: Journal of Infection and Public Health
https://www.readbyqxmd.com/read/28434701/upregulated-interleukins-il-6-il-10-and-il-13-in-immunoglobulin-g4-related-aortic-aneurysm-patients
#10
Satomi Kasashima, Atsuhiro Kawashima, Yoh Zen, Satoru Ozaki, Fuminori Kasashima, Masamitsu Endo, Yasushi Matsumoto, Kengo Kawakami
OBJECTIVE: Immunoglobulin (Ig) G4-related aortic aneurysms (IgG4-AAs) are a special aortic aneurysm among IgG4-related diseases (IgG4-RDs), which are inflammatory and fibrous conditions characterized by tumorous swelling of affected organs and high serum IgG4 concentrations. Recently, IgG4-RD pathogenesis was shown to be associated with T-helper-2 (Th2) and regulatory T (Treg) dominant cytokine production, such as interleukin (IL)-4, IL-10, and IL-13. IL-6 is a key proinflammatory cytokine contributing to lymphocyte and plasmacyte maturation and to atherosclerosis and aneurysm development...
April 20, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28434420/environmental-sampling-coupled-with-real-time-pcr-and-genotyping-to-investigate-the-source-of-a-q-fever-outbreak-in-a-work-setting
#11
A Hurtado, E Alonso, I Aspiritxaga, I López Etxaniz, B Ocabo, J F Barandika, J I Fernández-Ortiz DE Murúa, F Urbaneja, R Álvarez-Alonso, I Jado, A L García-Pérez
A Q fever outbreak was declared in February 2016 in a company that manufactures hoists and chains and therefore with no apparent occupational-associated risk. Coxiella burnetii infection was diagnosed by serology in eight of the 29 workers of the company; seven of them had fever or flu-like signs and five had pneumonia, one requiring hospitalisation. A further case of C. burnetii pneumonia was diagnosed in a local resident. Real-time PCR (RTi-PCR) showed a widespread distribution of C. burnetii DNA in dust samples collected from the plant facilities, thus confirming the exposure of workers to the infection inside the factory...
April 24, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/28433622/diminished-capacity-of-opsonization-and-immune-complex-solubilization-and-detection-of-anti-c1q-antibodies-in-sera-from-patients-with-hereditary-angioedema
#12
Daisuke Honda, Isao Ohsawa, Nobuyuki Sato, Hiroyuki Inoshita, Satoshi Mano, Yasuhiko Tomino, Yusuke Suzuki
BACKGROUND: Hereditary angioedema (HAE) is an autosomal dominant disease caused by deficiency of C1 esterase inhibitor. Symptoms of HAE include edema, which can potentially cause suffocation. Some patients with HAE exhibit immunological abnormalities, which could prevent an accurate diagnosis. Low levels of complement components are characteristic of HAE and in other settings are thought to reduce elimination of apoptotic cells and immune complex (IC). Thus, we aimed to experimentally clarify the mechanism of immunological abnormalities using sera from HAE patients...
April 19, 2017: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/28433574/serodiagnosis-of-toxoplasmosis-the-effect-of-measurement-of-igg-avidity-in-pregnant-women-in-rabat-in-morocco
#13
Majda Laboudi, Abderrahim Sadak
BACKGROUND: The diagnosis of toxoplasmosis in pregnant women during the early first trimester of pregnancy is very important for preventing congenital infection of the fetus; it will not only prevent the risk of transmitting the infection to the fetus but it will also enable to give these women a preventive treatment. In this study, the avidity test was performed on pregnant women during their first prenatal visit at the National Institute of Hygiene in Rabat, Morocco. FINDINGS: One hundred and twenty-eight sera samples were collected from 128 pregnant women between august 2015 and June 2016; these women were chosen retrospectively and were in their first 4 months of pregnancy...
April 19, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28432167/a-tale-of-two-vasculitides-biopsy-proven-giant-cell-arteritis-followed-by-the-independent-development-of-renal-limited-microscopic-polyangiitis
#14
Roman Zuckerman, Mayur Patel, Deborah R Alpert
We describe an 80-year-old woman who presented with headaches, bilateral jaw claudication and visual symptoms. She was diagnosed with giant cell arteritis, which was confirmed by temporal artery biopsy. She was treated with high-dose prednisone followed by a slow taper, with complete resolution of symptoms. Approximately 4 years later, she developed progressively worsening renal function associated with haematuria. Serological workup revealed a high-titre perinuclear antinuclear cytoplasmic antibody and antibodies to myeloperoxidase...
April 21, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28432047/delayed-lgi1-seropositivity-in-voltage-gated-potassium-channel-vgkc-complex-antibody-limbic-encephalitis
#15
Michael Sweeney, Jonathan Galli, Scott McNally, Anne Tebo, Thomas Haven, Perla Thulin, Stacey L Clardy
We utilise a clinical case to highlight why exclusion of voltage-gated potassium channel (VGKC)-complex autoantibody testing in serological evaluation of patients may delay or miss the diagnosis. A 68-year-old man presented with increasing involuntary movements consistent with faciobrachial dystonic seizures (FBDS). Initial evaluation demonstrated VGKC antibody seropositivity with leucine-rich glioma-inactivated 1 (LGI1) and contactin-associated protein-like 2 (CASPR2) seronegativity. Aggressive immunotherapy with methylprednisolone and plasmapheresis was started early in the course of his presentation...
April 20, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28431885/safety-of-adding-oats-to-a-gluten-free-diet-for-patients-with-celiac-disease-systematic-review-and-meta-analysis-of-clinical-and-observational-studies
#16
María Inés Pinto-Sánchez, Natalia Causada-Calo, Premysl Bercik, Alexander C Ford, Joseph A Murray, David Armstrong, Carol Semrad, Sonia S Kupfer, Armin Alaedini, Paul Moayyedi, Daniel A Leffler, Elena F Verdú, Peter Green
BACKGROUND & AIMS: Patients with celiac disease should maintain a gluten-free diet (GFD), excluding wheat, rye, and barley. Oats might increase the nutritional value of a GFD, but their including is controversial. We performed a systematic review and meta-analysis to evaluate the safety of oats as part of a GFD in patients with celiac disease. METHODS: We searched the Cochrane Central Register of Controlled Trials, MEDLINE, and EMBASE databases for clinical trials and observational studies of the effects of including oats in GFD of patients with celiac disease...
April 18, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28431115/spatial-distribution-of-falciparum-malaria-infections-in-zanzibar-implications-for-focal-drug-administration-strategies-targeting-asymptomatic-parasite-carriers
#17
Anders Björkman, Jackie Cook, Hugh Sturrock, Mwinyi Msellem, Abdullah Ali, Weiping Xu, Fabrizio Molteni, Roly Gosling, Chris Drakeley, Andreas Mårtensson
Background.: Optimal use of mass/targeted screen-and-treat or mass or focal drug administration as malaria elimination strategies remains unclear. We therefore studied spatial distribution of Plasmodium falciparum infections to compare simulated effects of these strategies on reducing the parasite reservoir in a pre-elimination setting. Methods.: P. falciparum rapid diagnostic tests (RDTs) and molecular (polymerase chain reaction [PCR]) and serological (enzyme-linked immunosorbent assay) analyses were performed on finger-prick blood samples from a population-based survey in 3 adjacent communities...
May 1, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28430889/accuracy-of-diagnostic-tests-for-schistosoma-mansoni-infection-in-asymptomatic-eritrean-refugees-serology-and-poc-cca-against-stool-microscopy
#18
Afona Chernet, Kerstin Kling, Véronique Sydow, Esther Kuenzli, Christoph Hatz, Jürg Utzinger, Lisette van Lieshout, Hanspeter Marti, Niklaus D Labhardt, Andreas Neumayr
Background: The unprecedented increase in number of African refugees arriving in Europe is confronting clinicians and general practitioners with the question of whether or not and how to screen migrants from endemic regions for Schistosoma mansoni infection. Methods: We assessed the accuracy of three different diagnostic tests for S.mansoni infection (stool microscopy [samples prepared by sedimentation technique], serology, and point-of-care circulating cathodic antigen [POC-CCA] urine cassette test) in 107 newly arrived asymptomatic Eritrean refugees in Switzerland...
April 19, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28430372/retinal-nerve-fibre-layer-thickness-is-reduced-in-metabolic-syndrome
#19
R Zarei, P Anvari, Y Eslami, G Fakhraie, M Mohammadi, A Jamali, M Afarideh, A Ghajar, S Heydarzade, A Esteghamati, S Moghimi
AIMS: To investigate retinal nerve fibre layer (RNFL) thickness in people with metabolic syndrome (MetS) and healthy controls. METHODS: A cross-sectional study was performed from March 2014 to January 2016. All participants underwent anthropometric and serological biochemical measurements, ophthalmological examination, and spectral-domain optical coherence tomography (SD-OCT). Individuals with elevated intraocular pressure, glaucoma, diabetic retinopathy and other ocular disorders were excluded...
April 21, 2017: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/28429245/assessing-pruritus-in-hidradenitis-suppurativa-a-cross-sectional-study
#20
Allard R J V Vossen, Annelien Schoenmakers, Kelsey R van Straalen, Errol P Prens, Hessel H van der Zee
BACKGROUND: Pruritus is still a forgotten aspect of hidradenitis suppurativa (HS) and, to date, has never been adequately studied. OBJECTIVE: The aim of this study was to determine the prevalence, and explore the characteristics, of pruritus in a well-defined cohort of HS patients. SETTING: An academic hospital-based cross-sectional study in The Netherlands. METHODS: A numerical rating scale (NRS, 0-10) was used to determine the prevalence of HS-related itch (NRS score ≥3)...
April 20, 2017: American Journal of Clinical Dermatology
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