Sebastian Klein, Nora Wuerdemann, Imke Demers, Christopher Kopp, Jennifer Quantius, Arthur Charpentier, Yuri Tolkach, Klaus Brinker, Shachi Jenny Sharma, Julie George, Jochen Hess, Fabian Stögbauer, Martin Lacko, Marijn Struijlaart, Mari F C M van den Hout, Steffen Wagner, Claus Wittekindt, Christine Langer, Christoph Arens, Reinhard Buettner, Alexander Quaas, Hans Christian Reinhardt, Ernst-Jan Speel, Jens Peter Klussmann
Human Papilloma Virus (HPV)-associated oropharyngeal squamous cell cancer (OPSCC) represents an OPSCC subgroup with an overall good prognosis with a rising incidence in Western countries. Multiple lines of evidence suggest that HPV-associated tumors are not a homogeneous tumor entity, underlining the need for accurate prognostic biomarkers. In this retrospective, multi-institutional study involving 906 patients from four centers and one database, we developed a deep learning algorithm (OPSCCnet), to analyze standard H&E stains for the calculation of a patient-level score associated with prognosis, comparing it to combined HPV-DNA and p16-status...
August 19, 2023: NPJ Digital Medicine