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https://www.readbyqxmd.com/read/29726031/patient-reported-health-related-quality-of-life-from-the-phase-iii-tourmaline-mm1-study-of-ixazomib-lenalidomide-dexamethasone-versus-placebo-lenalidomide-dexamethasone-in-relapsed-refractory-multiple-myeloma
#1
Xavier Leleu, Tamas Masszi, Nizar J Bahlis, Luisa Viterbo, Bartrum Baker, Peter Gimsing, Vladimir Maisnar, Olga Samoilova, Laura Rosiñol, Christian Langer, Kevin Song, Tohru Izumi, Charles Cleeland, Deborah Berg, Huamao Mark Lin, Yanyan Zhu, Tomas Skacel, Philippe Moreau, Paul G Richardson
TOURMALINE-MM1 is a phase III, randomized, double-blind, placebo-controlled study of ixazomib plus lenalidomide and dexamethasone (IRd) versus placebo-Rd in patients with relapsed/refractory multiple myeloma following 1-3 prior lines of therapy. The study met its primary endpoint, demonstrating significantly longer progression-free survival (PFS) in the IRd arm versus placebo-Rd arm (median 20.6 vs 14.7 months, hazard ratio 0.74, P = 0.01), with limited additional toxicity. Patient-reported health-related quality of life (HRQoL) was a secondary endpoint of TOURMALINE-MM1...
May 4, 2018: American Journal of Hematology
https://www.readbyqxmd.com/read/29716036/evaluation-of-phase-retrieval-approaches-in-magnified-x-ray-phase-nano-computerized-tomography-applied-to-bone-tissue
#2
Boliang Yu, Loriane Weber, Alexandra Pacureanu, Max Langer, Cecile Olivier, Peter Cloetens, Françoise Peyrin
X-ray phase contrast imaging offers higher sensitivity compared to conventional X-ray attenuation imaging and can be simply implemented by propagation when using a partially coherent synchrotron beam. We address the phase retrieval in in-line phase nano-CT using multiple propagation distances. We derive a method which extends Paganin's single distance method and compare it to the contrast transfer function (CTF) approach in the case of a homogeneous object. The methods are applied to phase nano-CT data acquired at the voxel size of 30 nm (ID16A, ESRF, Grenoble, France)...
April 30, 2018: Optics Express
https://www.readbyqxmd.com/read/29600052/a-pooled-analysis-of-advanced-nonsquamous-non-small-cell-lung-cancer-patients-with-stable-treated-brain-metastases-in-two-phase-ii-trials-receiving-bevacizumab-and-pemetrexed-as-second-line-therapy
#3
Matthew A Gubens, Jody C Chuang, Wallace Akerley, Corey J Langer, Christelle Clément-Duchêne, Melanie San Pedro-Salcedo, A Dimitrios Colevas, Konstantin Dragnev, Mark A Socinski, Heather A Wakelee
Background: Brain metastases are a common complication of advanced non-small cell lung cancer (NSCLC). Patients with brain metastases were excluded from the registration trials of bevacizumab that showed a survival benefit with the use of angiogenesis inhibition. Methods: In this study, we pooled data from two separate trials designed to evaluate the risk of central nervous system (CNS) hemorrhage in patients with stable treated brain metastases to look specifically at both the safety and efficacy of bevacizumab and pemetrexed when used as second-line treatment in NSCLC patients with stable treated brain metastases...
January 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29543064/biodynamic-excisional-skin-tension-lines-for-surgical-excisions-untangling-the-science
#4
S P Paul
Objective There remains confusion between Langer's lines and wrinkle lines with respect to the optimal orientation of elliptical excisions on the trunk. This study sought to determine the directions of wound closure that would result in least wound tension after skin lesion excisions. Materials and methods Some 1181 consecutive skin lesion excisions were investigated (age range 13-95 years, median 64 years) using a tensiometer to determine directions of least wound tension. These lines were mapped. Skin tension measurements were taken during the procedure and analysed...
April 2018: Annals of the Royal College of Surgeons of England
https://www.readbyqxmd.com/read/29511910/intravenous-versus-oral-etoposide-efficacy-and-correlation-to-clinical-outcome-in-patients-with-high-grade-metastatic-gastroenteropancreatic-neuroendocrine-neoplasms-who-g3
#5
Abir Salwa Ali, Malin Grönberg, Seppo W Langer, Morten Ladekarl, Geir Olav Hjortland, Lene Weber Vestermark, Pia Österlund, Staffan Welin, Henning Grønbæk, Ulrich Knigge, Halfdan Sorbye, Eva Tiensuu Janson
High-grade gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs, G3) are aggressive cancers of the digestive system with poor prognosis and survival. Platinum-based chemotherapy (cisplatin/carboplatin + etoposide) is considered the first-line palliative treatment. Etoposide is frequently administered intravenously; however, oral etoposide may be used as an alternative. Concerns for oral etoposide include decreased bioavailability, inter- and intra-patient variability and patient compliance. We aimed to evaluate possible differences in progression-free survival (PFS) and overall survival (OS) in patients treated with oral etoposide compared to etoposide given as infusion...
March 6, 2018: Medical Oncology
https://www.readbyqxmd.com/read/29422017/metabolomic-profiling-identifies-distinct-phenotypes-for-ass1-positive-and-negative-gbm
#6
Lina Mörén, Richard Perryman, Tim Crook, Julia K Langer, Kevin Oneill, Nelofer Syed, Henrik Antti
BACKGROUND: Tumour cells have a high demand for arginine. However, a subset of glioblastomas has a defect in the arginine biosynthetic pathway due to epigenetic silencing of the rate limiting enzyme argininosuccinate synthetase (ASS1). These tumours are auxotrophic for arginine and susceptible to the arginine degrading enzyme, pegylated arginine deiminase (ADI-PEG20). Moreover, ASS1 deficient GBM have a worse prognosis compared to ASS1 positive tumours. Since altered tumour metabolism is one of the hallmarks of cancer we were interested to determine if these two subtypes exhibited different metabolic profiles that could allow for their non-invasive detection as well as unveil additional novel therapeutic opportunities...
February 8, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29389052/umpolung-at-boron-ancillary-ligand-induced-formation-of-boron-based-donor-ligands-from-phosphine-boranes
#7
Lisa Vondung, Lukas Alig, Monika Ballmann, Robert Langer
Easy-to-prepare η2 -coordinated phosphine-borane ligands are demonstrated to liberate hydrogen upon treatment with different σ-donor/π-acceptor ligands (CO, tBuNC, CN- ). Depending on the utilized ancillary ligand, different reaction pathways are observed, ranging from simple hydride protonation to iron-boron bond formation and subsequent rearrangement to pincer-type ligands based on a tricoordinate boron centre. The last-named reactivity is in line with a formal umpolung at the boron centre from a Lewis acidic borane to a Lewis basic boron-based donor ligand...
February 1, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29378634/evaluating-antibody-functional-activity-and-strain-specificity-of-vaccine-candidates-for-malaria-in-pregnancy-using-in-vitro-phagocytosis-assays
#8
Mirja Hommel, Jo-Anne Chan, Alexandra J Umbers, Christine Langer, Stephen J Rogerson, Joseph D Smith, James G Beeson
BACKGROUND: Malaria in pregnancy is a major cause of poor maternal and infant health, and is associated with the sequestration of P. falciparum-infected erythrocytes (IE) in the placenta. The leading vaccine candidate for pregnancy malaria, VAR2CSA, has been shown to induce antibodies that inhibit IE adhesion to the placental receptor chondroitin sulfate A (CSA), potentially preventing placental infection. However, the ability of vaccination-induced antibodies to promote opsonic phagocytosis is not well defined, but likely to be an important component of protective immunity...
January 29, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29365241/pityriasis-rosea-diagnosis-and-treatment
#9
Jose M Villalon-Gomez
Pityriasis rosea is a common self-limiting rash that usually starts with a herald patch on the trunk and progresses along the Langer lines to a generalized rash over the trunk and limbs. The diagnosis is based on clinical and physical examination findings. The herald patch is an erythematous lesion with an elevated border and depressed center. The generalized rash usually presents two weeks after the herald patch. Patients can develop general malaise, fatigue, nausea, headaches, joint pain, enlarged lymph nodes, fever, and sore throat before or during the course of the rash...
January 1, 2018: American Family Physician
https://www.readbyqxmd.com/read/29320535/rhombic-organization-of-microvilli-domains-found-in-a-cell-model-of-the-human-intestine
#10
Jonas Franz, Jonas Grünebaum, Marcus Schäfer, Dennis Mulac, Florian Rehfeldt, Klaus Langer, Armin Kramer, Christoph Riethmüller
Symmetry is rarely found on cellular surfaces. An exception is the brush border of microvilli, which are essential for the proper function of transport epithelia. In a healthy intestine, they appear densely packed as a 2D-hexagonal lattice. For in vitro testing of intestinal transport the cell line Caco-2 has been established. As reported by electron microscopy, their microvilli arrange primarily in clusters developing secondly into a 2D-hexagonal lattice. Here, atomic force microscopy (AFM) was employed under aqueous buffer conditions on Caco-2 cells, which were cultivated on permeable filter membranes for optimum differentiation...
2018: PloS One
https://www.readbyqxmd.com/read/29276879/unilateral-pityriasis-rosea-in-a-child-a-rare-clinical-presentation
#11
Atiye Oğrum
Oğrum A. Unilateral pityriasis rosea in a child: A rare clinical presentation. Turk J Pediatr 2017; 59: 214-216. Pityriasis rosea is a common papulosquamous disorder with occasional variations in lesion morphology, distribution, number and course of disease. The lesions are classically arranged with their long axes parallel to the Langer`s lines of cleavage and typically affect the trunk and the proximal extremities. Variations in the distribution of pityriasis rosea include inversus, localized, and unilateral forms...
2017: Turkish Journal of Pediatrics
https://www.readbyqxmd.com/read/29186943/modified-minimally-invasive-direct-anterior-approach-through-a-bikini-incision-for-total-hip-arthroplasty-technique-and-results-in-young-female-patients
#12
C Faldini, A Mazzotti, F Perna, N Stefanini, A Panciera, F Pilla, A Ruffilli, E M Neonakis, F Traina
Direct anterior approach for THA has gained popularity over the last years. However, concerns have been raised regarding the cosmetic, related to the incision that does not respect the Langer’s skin tension line and may produce hypertrophic scars. The aim of this study was to analyze the preliminary results in 22 young female patients undergoing THA through a minimally invasive direct anterior approach using a modified oblique bikini incision. Clinical evaluations showed an improvement of WOMAC, UCLA and Harris Hip Score at 5-month follow-up...
October 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29159004/linear-malignant-melanoma-in-situ-reports-and-review-of-cutaneous-malignancies-presenting-as-linear-skin-cancer
#13
Philip R Cohen
Melanomas usually present as oval lesions in which the borders may be irregular. Other morphological features of melanoma include clinical asymmetry, variable color, diameter greater than 6 mm and evolving lesions. Two males whose melanoma in situ presented as linear skin lesions are described and cutaneous malignancies that may appear linear in morphology are summarized in this report. A medical literature search engine, PubMed, was used to search the following terms: cancer, cutaneous, in situ, linear, malignant, malignant melanoma, melanoma in situ, neoplasm, and skin...
September 18, 2017: Curēus
https://www.readbyqxmd.com/read/29129435/etirinotecan-pegol-nktr-102-in-third-line-treatment-of-patients-with-metastatic-or-recurrent-non-small-cell-lung-cancer-results-of-a-phase-ii-study
#14
Charu Aggarwal, Roger B Cohen, Eddy Yu, Wei-Ting Hwang, Joshua M Bauml, Evan Alley, Tracey L Evans, Corey J Langer
BACKGROUND: Third-line treatment options are limited for patients with metastatic non-small-cell lung cancer (NSCLC). Etirinotecan pegol (NKTR-102) is a long-acting topoisomerase-I inhibitor. We conducted a single-arm phase II trial to evaluate its efficacy in third-line treatment. PATIENTS AND METHODS: Patients aged ≥ 18 years with histologically proven NSCLC who had received 2 previous systemic therapy regimens, measurable disease, Eastern Cooperative Oncology Group (ECOG) performance status ≤ 1, and adequate end-organ function were eligible...
March 2018: Clinical Lung Cancer
https://www.readbyqxmd.com/read/29108919/egfr-immunohistochemistry-as-biomarker-for-antibody-based-therapy-of-squamous-nsclc-experience-from-the-first-ring-trial-of-the-german-quality-assurance-initiative-for-pathology-quip-%C3%A2
#15
Iver Petersen, Manfred Dietel, Wolf J Geilenkeuser, Masoud Mireskandari, Wilko Weichert, Katja Steiger, Andreas H Scheel, Reinhard Büttner, Peter Schirmacher, Arne Warth, Felix Lasitschka, Hans-Ulrich Schildhaus, Thomas Kirchner, Simone Reu, Hans Kreipe, Florian Länger, Markus Tiemann, Christoph Schulte, Korinna Jöhrens
BACKGROUND: EGFR and its downstream signaling pathway are important targets for cancer therapy. Recently, the monoclonal anti-EGFR antibody Necitumumab in combination with gemcitabine and cisplatin was approved (EMA/14106/2016) for first-line treatment of squamous non-small cell carcinoma (SqNSCLC). Eligibility was restricted to cases with positive EGFR expression. In this context, a ring trial of the Quality Assurance Initiative for Pathology (QuIP(®)) was launched to prepare the German pathology community for a reliable and reproducible, immunohistochemically based biomarker test...
September 28, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/29106408/cell-type-specific-metabolic-labeling-of-nascent-proteomes-in-vivo
#16
Beatriz Alvarez-Castelao, Christoph T Schanzenbächer, Cyril Hanus, Caspar Glock, Susanne Tom Dieck, Aline R Dörrbaum, Ina Bartnik, Belquis Nassim-Assir, Elena Ciirdaeva, Anke Mueller, Daniela C Dieterich, David A Tirrell, Julian D Langer, Erin M Schuman
Although advances in protein labeling methods have made it possible to measure the proteome of mixed cell populations, it has not been possible to isolate cell-type-specific proteomes in vivo. This is because the existing methods for metabolic protein labeling in vivo access all cell types. We report the development of a transgenic mouse line where Cre-recombinase-induced expression of a mutant methionyl-tRNA synthetase (L274G) enables the cell-type-specific labeling of nascent proteins with a non-canonical amino-acid and click chemistry...
December 2017: Nature Biotechnology
https://www.readbyqxmd.com/read/29077679/revisiting-the-skin-lines-on-the-forehead-and-glabellar-area
#17
Kun Hwang
This paper attempted to revisit the skin lines in forehead and glabellar area.Using PubMed, Scopus, and Google, papers describing skin tension lines of face were searched. Papers with illustrations or pictures of the facial lines were selected and reviewed. The studies of the skin lines in the forehead and glabellar area were analyzed.Langer used the term "cleavage of the cutis, anatomical lines." Over the forehead, he found a border zone of horizontal folds that were interrupted many times by the ascending folds coming from the flabella area...
January 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29057240/emerging-uses-of-circulating-tumor-dna-in-advanced-stage-non-small-cell-lung-cancer
#18
REVIEW
Melina Marmarelis, Jeffrey C Thompson, Charu Aggarwal, Tracey L Evans, Erica Carpenter, Roger B Cohen, Corey J Langer, Joshua Bauml
Targeted therapies have dramatically changed the treatment paradigm for a select group of patients with non-small cell lung cancer (NSCLC) whose tumors harbor targetable genetic aberrations. Patients with such genetic changes enjoy excellent responses to tyrosine kinase inhibitors (TKIs), but resistance is nearly inevitable. Resistance to first line TKIs is heterogeneous and multifactorial-multiple resistance mechanisms have been reported, and different metastatic foci in the same patient may have distinct resistance mechanisms...
September 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28940241/influence-of-oatps-on-hepatic-disposition-of-erlotinib-measured-with-positron-emission-tomography
#19
Martin Bauer, Akihiro Matsuda, Beatrix Wulkersdorfer, Cécile Philippe, Alexander Traxl, Csilla Özvegy-Laczka, Johann Stanek, Lukas Nics, Eva-Maria Klebermass, Stefan Poschner, Walter Jäger, Izabel Patik, Éva Bakos, Gergely Szakács, Wolfgang Wadsak, Marcus Hacker, Markus Zeitlinger, Oliver Langer
To assess hepatic disposition of erlotinib, we performed positron emission tomography (PET) scans with [(11) C]erlotinib in healthy volunteers without and with oral pretreatment with a therapeutic erlotinib dose (300 mg). Erlotinib pretreatment significantly decreased the liver exposure to [(11) C]erlotinib with a concomitant increase in blood exposure, pointing to the involvement of a carrier-mediated hepatic uptake mechanism. Using cell lines overexpressing human organic anion-transporting polypeptides (OATP) 1B1, 1B3 or 2B1, we show that [(11) C]erlotinib is selectively transported by OATP2B1...
September 22, 2017: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28903368/expression-analysis-of-lc3b-and-p62-indicates-intact-activated-autophagy-is-associated-with-an-unfavorable-prognosis-in-colon-cancer
#20
Monique Niklaus, Olivia Adams, Sabina Berezowska, Inti Zlobec, Franziska Graber, Julia Slotta-Huspenina, Ulrich Nitsche, Robert Rosenberg, Mario P Tschan, Rupert Langer
Autophagy is a lysosomal degradation and recycling process implicated in cancer progression and therapy resistance. We assessed the impact of basal autophagy in colon cancer (CC) in vitro and ex vivo. Functional autophagy was demonstrated in CC cell lines (LoVo; HT-29) showing a dose-dependent increase of the autophagy markers LC3B, p62 and autophagic vesciles upon increasing concentrations of the autophagy inhibitor chloroquine, which was demonstrated by immunoblotting, immunofluorescence and electron microscopy...
August 15, 2017: Oncotarget
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