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https://www.readbyqxmd.com/read/28500398/comparative-clinical-utility-of-tumor-genomic-testing-and-cell-free-dna-in-metastatic-breast-cancer
#1
Kara N Maxwell, Danielle Soucier-Ernst, Emin Tahirovic, Andrea B Troxel, Candace Clark, Michael Feldman, Christopher Colameco, Bijal Kakrecha, Melissa Langer, David Lieberman, Jennifer J D Morrissette, Matt R Paul, Tien-Chi Pan, Stephanie Yee, Natalie Shih, Erica Carpenter, Lewis A Chodosh, Angela DeMichele
PURPOSE: Breast cancer metastases differ biologically from primary disease; therefore, metastatic biopsies may assist in treatment decision making. Commercial genomic testing of both tumor and circulating tumor DNA have become available clinically, but utility of these tests in breast cancer management remains unclear. METHODS: Patients undergoing a clinically indicated metastatic tumor biopsy were consented to the ongoing METAMORPH registry. Tumor and blood were collected at the time of disease progression before subsequent therapy, and patients were followed for response on subsequent treatment...
May 12, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28479368/safety-analyses-of-pemetrexed-cisplatin-and-pemetrexed-maintenance-therapies-in-patients-with-advanced-non-squamous-nsclc-retrospective-analyses-from-2-phase-iii-studies
#2
Corey J Langer, Luis G Paz-Ares, Antoinette J Wozniak, Cesare Gridelli, Filippo de Marinis, Jean-Louis Pujol, Belen San Antonio, Jian Chen, Jingyi Liu, Ana B Oton, Carla Visseren-Grul, Giorgio V Scagliotti
BACKGROUND: In a phase III study, maintenance pemetrexed showed superior survival over placebo (PARAMOUNT) for patients with advanced non-squamous non-small cell lung cancer (NSCLC) who completed 4 cycles of pemetrexed plus cisplatin (PC) induction therapy, with low incidence of treatment-emergent adverse events (TEAEs) generally associated with pemetrexed. Prior analyses did not account for toxicities carried over from induction; thus, the current analysis was developed to understand toxicities that may be attributed to pemetrexed maintenance versus PC induction, and how treatment duration affects toxicity...
April 12, 2017: Clinical Lung Cancer
https://www.readbyqxmd.com/read/28465795/the-comparison-of-modified-semilunar-technique-in-conjunction-with-connective-tissue-and-subepithelial-connective-tissue-graft-for-root-coverage-a-randomized-controlled-trial
#3
Niloofar Jenabian, Nafiseh Khanjani, Ali Bijani
BACKGROUND: Gingival recession may result in aesthetically unfavourable effects, difficulty in plaque control, increased susceptibility to root caries, and dentin hypersensitivity. OBJECTIVE: The aim of this study was to compare the use of modified semilunar techniques with connective tissue and subepithelial connective tissue grafts (Langer) for denuded root surface coverage. METHODS: In this randomized clinical trial, fourteen localized recessions of Miller class I to II were treated in 5 subjects...
February 2017: Electronic Physician
https://www.readbyqxmd.com/read/28409544/hypoxia-and-the-hypoxia-regulated-transcription-factor-hif-1%C3%AE-suppress-the-host-defence-of-airway-epithelial-cells
#4
Markus Polke, Frederik Seiler, Philipp M Lepper, Andreas Kamyschnikow, Frank Langer, Dominik Monz, Christian Herr, Robert Bals, Christoph Beisswenger
Chronic diseases of the respiratory tract, such as cystic fibrosis, are associated with mucosal and systemic hypoxia. Innate immune functions of airway epithelial cells are required to prevent and control infections of the lung parenchyma. The transcription factor hypoxia-inducible factor 1α (HIF-1α) regulates cellular adaptation to low oxygen conditions. Here, we show that hypoxia and HIF-1α regulate innate immune mechanisms of cultured human bronchial epithelial cells (HBECs). Exposure of primary HBECs to hypoxia or the prolyl hydroxylase inhibitor dimethyloxaloylglycine (DMOG) resulted in a significantly decreased expression of inflammatory mediators (IL-6, IFN-γ-induced protein 10) in response to ligands for TLRs (flagellin, polyI:C) and Pseudomonas aeruginosa, whereas the expression of inflammatory mediators was not affected by hypoxia or DMOG in the absence of microbial factors...
May 2017: Innate Immunity
https://www.readbyqxmd.com/read/28334658/extraction-of-the-3d-local-orientation-of-myocytes-in-human-cardiac-tissue-using-x-ray-phase-contrast-micro-tomography-and-multi-scale-analysis
#5
François Varray, Iulia Mirea, Max Langer, Françoise Peyrin, Laurent Fanton, Isabelle E Magnin
This paper presents a methodology to access the 3D local myocyte arrangements in fresh human post-mortem heart samples. We investigated the cardiac micro-structure at a high and isotropic resolution of 3.5 µm in three dimensions using X-ray phase micro-tomography at the European Synchrotron Radiation Facility. We then processed the reconstructed volumes to extract the 3D local orientation of the myocytes using a multi-scale approach with no segmentation. We created a simplified 3D model of tissue sample made of simulated myocytes with known size and orientations, to evaluate our orientation extraction method...
February 20, 2017: Medical Image Analysis
https://www.readbyqxmd.com/read/28316241/investigating-the-cellular-specificity-in-tumors-of-a-surface-converting-nanoparticle-by-multimodal-imaging
#6
Francois Fay, Line Hansen, Stefanie J C G Hectors, Brenda L Sanchez-Gaytan, Yiming Zhao, Jun Tang, Jazz Munitz, Amr Alaarg, Mounia S Braza, Anita Gianella, Stuart A Aaronson, Thomas Reiner, Jørgen Kjems, Robert Langer, Freek J M Hoeben, Henk M Janssen, Claudia Calcagno, Gustav J Strijkers, Zahi A Fayad, Carlos Pérez-Medina, Willem J M Mulder
Active targeting of nanoparticles through surface functionalization is a common strategy to enhance tumor delivery specificity. However, active targeting strategies tend to work against long polyethylene glycol's shielding effectiveness and associated favorable pharmacokinetics. To overcome these limitations, we developed a matrix metalloproteinase-2 sensitive surface-converting polyethylene glycol coating. This coating prevents nanoparticle-cell interaction in the bloodstream, but, once exposed to matrix metalloproteinase-2, i...
May 5, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/28179198/cesarean-scar-ectopic-pregnancy-laparoscopic-resection-and-total-scar-dehiscence-repair-a-case-report
#7
Sara Mahgoub, Victor Gabriele, Emilie Faller, Bruno Langer, Arnaud Wattiez, Lise Lecointre, Cherif Akladios
STUDY OBJECTIVE: Illustrate laparoscopic technique for resection of cesarean scar ectopic pregnancy, associated with isthmocele repair. DESIGN: Case report SETTING: Tertiary referral centre in Strasbourg, France. The study was approved by the local IRB. BACKGROUND: Cesarean scar pregnancy is a rare form of ectopic pregnancy. The major risk of this type of pregnancy is the early uterine rupture with massive bleeding and maternal life-threatening...
February 4, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28152774/quality-of-life-qol-in-patients-pts-with-squamous-scc-nsclc-treated-with-nab-paclitaxel-with-carboplatin-nab-p-c-induction-therapy-interim-analysis-of-the-phase-iii-abound-sqm-study
#8
Corey J Langer, Robert M Jotte, Edward S Kim, Amy Ko, Teng Jin Ong, Mark A Socinski, Peter Staib, Nataliya Trunova, David R Spigel
64 Background: Recent data on QoL in pts with advanced NSCLC treated with platinum-doublets are limited. This interim analysis evaluated QoL in pts with SCC NSCLC treated with nab-P/C during the induction part of the ABOUND.sqm study. METHODS: In the ongoing phase III ABOUND.sqm study, pts with advanced SCC NSCLC are treated with first-line nab-P 100 mg/m(2) d 1, 8, 15 and C AUC 6 mg•min/mL d 1 (21-d cycles) for 4 cycles (induction). Pts not progressing after 4 cycles are randomized 2:1 to maintenance nab-P 100 mg/m(2)d 1 and 8 of each 21-d cycle + best supportive care (BSC) or BSC alone until progression...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28062918/glycine-decarboxylase-and-hif-1%C3%AE-expression-are-negative-prognostic-factors-in-primary-resected-early-stage-non-small-cell-lung-cancer
#9
Sabina Berezowska, José A Galván, Rupert Langer, Lukas Bubendorf, Spasenija Savic, Mathias Gugger, Ralph A Schmid, Thomas M Marti
Glycine decarboxylase (GLDC) was recently described as a critical enzyme of tumor-initiating cells and, thus, a driver of tumorigenesis in lung non-small cell cancer (NSCC). It is important in metabolism under hypoxic conditions. Hypoxia-inducible factor 1-alpha (HIF-1α) is the unique subunit that determines HIF system activity, thereby regulating the adverse effects of hypoxia on cancer outcome. We examined the expression and prognostic significance of GLDC and HIF-1α in primary resected stage I/II NSCC...
March 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/27868283/non-invasive-evaluation-of-skin-tension-lines-with-elastic-waves
#10
C Deroy, M Destrade, A Mc Alinden, A Ní Annaidh
BACKGROUND: Since their discovery by Karl Langer in the 19th Century, Skin Tension Lines (STLs) have been used by surgeons to decide the location and orientation of an incision. Although these lines are patient-specific, most surgeons rely on generic maps to determine their orientation. Beyond the imprecise pinch test, there remains no accepted method for determining STLs in vivo. METHODS: (i) The speed of an elastic motion travelling radially on the skin of canine cadavers was measured with a commercial device called the Reviscometer(®) ...
November 20, 2016: Skin Research and Technology
https://www.readbyqxmd.com/read/27863923/pretreatment-red-blood-cell-total-folate-concentration-is-associated-with-response-to-pemetrexed-in-stage-iv-nonsquamous-non-small-cell-lung-cancer
#11
Stephen J Bagley, Steven Vitale, Suhong Zhang, Charu Aggarwal, Tracey L Evans, Evan W Alley, Roger B Cohen, Corey J Langer, Ian A Blair, Anil Vachani, Alexander S Whitehead
INTRODUCTION: Pemetrexed inhibits folate-dependent enzymes involved in pyrimidine and purine synthesis. Previous studies of genetic variation in these enzymes as predictors of pemetrexed efficacy have yielded inconsistent results. We investigated whether red blood cell (RBC) total folate, a phenotypic rather than genotypic, marker of cellular folate status was associated with the response to pemetrexed-based chemotherapy in advanced nonsquamous non-small-cell lung cancer (NSCLC). MATERIALS AND METHODS: We conducted a prospective cohort study of patients with stage IV nonsquamous NSCLC receiving first-line chemotherapy containing pemetrexed...
March 2017: Clinical Lung Cancer
https://www.readbyqxmd.com/read/27789942/comparison-of-cellular-effects-of-starch-coated-spions-and-poly-lactic-co-glycolic-acid-matrix-nanoparticles-on-human-monocytes
#12
COMPARATIVE STUDY
Dominik Gonnissen, Ying Qu, Klaus Langer, Cengiz Öztürk, Yuliang Zhao, Chunying Chen, Guiscard Seebohm, Martina Düfer, Harald Fuchs, Hans-Joachim Galla, Kristina Riehemann
Within the last years, progress has been made in the knowledge of the properties of medically used nanoparticles and their toxic effects, but still, little is known about their influence on cellular processes of immune cells. The aim of our comparative study was to present the influence of two different nanoparticle types on subcellular processes of primary monocytes and the leukemic monocyte cell line MM6. We used core-shell starch-coated superparamagnetic iron oxide nanoparticles (SPIONs) and matrix poly(lactic-co-glycolic acid) (PLGA) nanoparticles for our experiments...
2016: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/27745820/carboplatin-and-pemetrexed-with-or-without-pembrolizumab-for-advanced-non-squamous-non-small-cell-lung-cancer-a-randomised-phase-2-cohort-of-the-open-label-keynote-021-study
#13
Corey J Langer, Shirish M Gadgeel, Hossein Borghaei, Vassiliki A Papadimitrakopoulou, Amita Patnaik, Steven F Powell, Ryan D Gentzler, Renato G Martins, James P Stevenson, Shadia I Jalal, Amit Panwalkar, James Chih-Hsin Yang, Matthew Gubens, Lecia V Sequist, Mark M Awad, Joseph Fiore, Yang Ge, Harry Raftopoulos, Leena Gandhi
BACKGROUND: Limited evidence exists to show that adding a third agent to platinum-doublet chemotherapy improves efficacy in the first-line advanced non-small-cell lung cancer (NSCLC) setting. The anti-PD-1 antibody pembrolizumab has shown efficacy as monotherapy in patients with advanced NSCLC and has a non-overlapping toxicity profile with chemotherapy. We assessed whether the addition of pembrolizumab to platinum-doublet chemotherapy improves efficacy in patients with advanced non-squamous NSCLC...
November 2016: Lancet Oncology
https://www.readbyqxmd.com/read/27619946/preloading-with-l-bpa-l-tyrosine-and-l-dopa-enhances-the-uptake-of-18-f-fbpa-in-human-and-mouse-tumour-cell-lines
#14
Bettina Wingelhofer, Katharina Kreis, Severin Mairinger, Viktoria Muchitsch, Johann Stanek, Thomas Wanek, Oliver Langer, Claudia Kuntner
Aim of this study was to investigate if cellular [(18)F]FBPA uptake can be increased upon preloading with amino acids. [(18)F]FBPA uptake was assessed in HuH-7, CaCo-2 and B16-F1 cells pretreated with different concentrations or incubation times of L-BPA, L-tyrosine or L-DOPA. Without preloading, highest uptake of [(18)F]FBPA was observed in B16-F1 cells, followed by CaCo-2 cells and HuH-7 cells. In all cell lines higher [(18)F]FBPA accumulation (up to 1.65-fold) was obtained with increasing L-BPA, L-DOPA and L-tyrosine concentrations...
December 2016: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/27614920/synthesis-and-preclinical-characterization-of-1-6-deoxy-6-18-f-fluoro-%C3%AE-d-allofuranosyl-2-nitroimidazole-%C3%AE-6-18-f-fazal-as-a-positron-emission-tomography-radiotracer-to-assess-tumor-hypoxia
#15
Thomas Wanek, Katharina Kreis, Petra Križková, Anna Schweifer, Christoph Denk, Johann Stanek, Severin Mairinger, Thomas Filip, Michael Sauberer, Patricia Edelhofer, Alexander Traxl, Viktoria E Muchitsch, Kurt Mereiter, Friedrich Hammerschmidt, Carol E Cass, Vijaya L Damaraju, Oliver Langer, Claudia Kuntner
Positron emission tomography (PET) using fluorine-18 ((18)F)-labeled 2-nitroimidazole radiotracers has proven useful for assessment of tumor oxygenation. However, the passive diffusion-driven cellular uptake of currently available radiotracers results in slow kinetics and low tumor-to-background ratios. With the aim to develop a compound that is actively transported into cells, 1-(6'-deoxy-6'-[(18)F]fluoro-β-d-allofuranosyl)-2-nitroimidazole (β-[(18)F]1), a putative nucleoside transporter substrate, was synthetized by nucleophilic [(18)F]fluoride substitution of an acetyl protected labeling precursor with a tosylate leaving group (β-6) in a final radiochemical yield of 12±8% (n=10, based on [(18)F]fluoride starting activity) in a total synthesis time of 60min with a specific activity at end of synthesis of 218±58GBq/μmol (n=10)...
November 1, 2016: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/27594517/a-size-selective-intracellular-delivery-platform
#16
May Tun Saung, Armon Sharei, Viktor A Adalsteinsson, Nahyun Cho, Tushar Kamath, Camilo Ruiz, Jesse Kirkpatrick, Nehal Patel, Mari Mino-Kenudson, Sarah P Thayer, Robert Langer, Klavs F Jensen, Andrew S Liss, J Christopher Love
Identifying and separating a subpopulation of cells from a heterogeneous mixture are essential elements of biological research. Current approaches require detailed knowledge of unique cell surface properties of the target cell population. A method is described that exploits size differences of cells to facilitate selective intracellular delivery using a high throughput microfluidic device. Cells traversing a constriction within this device undergo a transient disruption of the cell membrane that allows for cytoplasmic delivery of cargo...
September 4, 2016: Small
https://www.readbyqxmd.com/read/27466628/identification-of-polymer-surface-adsorbed-proteins-implicated-in-pluripotent-human-embryonic-stem-cell-expansion
#17
Moamen Hammad, Wei Rao, James G W Smith, Daniel G Anderson, Robert Langer, Lorraine E Young, David A Barrett, Martyn C Davies, Chris Denning, Morgan R Alexander
Improved biomaterials are required for application in regenerative medicine, biosensing, and as medical devices. The response of cells to the chemistry of polymers cultured in media is generally regarded as being dominated by proteins adsorbed to the surface. Here we use mass spectrometry to identify proteins adsorbed from a complex mouse embryonic fibroblast (MEF) conditioned medium found to support pluripotent human embryonic stem cell (hESC) expansion on a plasma etched tissue culture polystyrene surface...
August 16, 2016: Biomaterials Science
https://www.readbyqxmd.com/read/27457235/antitumor-evaluation-of-two-selected-pakistani-plant-extracts-on-human-bone-and-breast-cancer-cell-lines
#18
Nadja Engel, Iftikhar Ali, Anna Adamus, Marcus Frank, Akber Dad, Sajjad Ali, Barbara Nebe, Muhammad Atif, Muhammad Ismail, Peter Langer, Viqar Uddin Ahmad
BACKGROUND: The medicinal plants Vincetoxicum arnottianum (VSM), Berberis orthobotrys (BORM), Onosma hispida (OHRM and OHAM) and Caccinia macranthera (CMM) are used traditionally in Pakistan and around the world for the treatment of various diseases including cancer, dermal infections, uterine tumor, wounds etc. The present study focuses on the investigation of the selected Pakistani plants for their potential as anticancer agents on human bone and breast cancer cell lines in comparison with non-tumorigenic control cells...
July 26, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27453542/a-new-skin-tensiometer-device-computational-analyses-to-understand-biodynamic-excisional-skin-tension-lines
#19
Sharad P Paul, Justin Matulich, Nick Charlton
One of the problems in planning cutaneous surgery is that human skin is anisotropic, or directionally dependent. Indeed, skin tension varies between individuals and at different body sites. Many a surgeon has tried to design different devices to measure skin tension to help plan excisional surgery, or to understand wound healing. However, many of the devices have been beset with problems due to many confounding variables - differences in technical ability, material (sutures) used and variability between different users...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27416779/constitutive-modeling-of-stress-softening-and-permanent-set-in-a-porcine-skin-tissue-impact-of-the-storage-preservation
#20
A S Caro-Bretelle, P Ienny, R Leger, S Corn, I Bazin, F Bretelle
Prior to testing, soft tissues are usually maintained in different media and additives (solution, air, cryopreservant…) under various environment conditions (temperature, storage duration….). In many cases, results from mechanical tests performed on these stored tissues are supposed to be as closed as possible to the fresh ones. In the present work, cyclic tensile tests were performed with increasing values of strain on porcine skin tissues (excised following the Langer's lines) to enhance tissues mechanical nonlinearity such as softening behavior and permanent set...
June 27, 2016: Journal of Biomechanics
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