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https://www.readbyqxmd.com/read/28429247/a-review-of-the-novel-application-and-potential-adverse-effects-of-proton-pump-inhibitors
#1
REVIEW
Li-Yuan Yu, Lu-Ning Sun, Xue-Hui Zhang, Yue-Qi Li, Lei Yu, Zi-Qing-Yun Yuan, Ling Meng, Hong-Wen Zhang, Yong-Qing Wang
Proton pump inhibitors (PPIs) are known as a class of pharmaceutical agents that target H(+)/K(+)-ATPase, which is located in gastric parietal cells. PPIs are widely used in the treatment of gastric acid-related diseases including peptic ulcer disease, erosive esophagitis and gastroesophageal reflux disease, and so on. These drugs present an excellent safety profile and have become one of the most commonly prescribed drugs in primary and specialty care. Except for gastric acid-related diseases, PPIs can also be used in the treatment of Helicobacter pylori infection, viral infections, respiratory system diseases, cancer and so on...
April 20, 2017: Advances in Therapy
https://www.readbyqxmd.com/read/28427896/toll-like-receptor-2-an-important-immunomodulatory-molecule-during-helicobacter-pylori-infection
#2
REVIEW
Maryam Nemati, Tiziana Larussa, Hossein Khorramdelazad, Merat Mahmoodi, Abdollah Jafarzadeh
Toll like receptors (TLRs) are an essential subset of pathogen recognition receptors (PRRs) which identify the microbial components and contribute in the regulation of innate and adaptive immune responses against the infectious agents. The TLRs, especially TLR2, TLR4, TLR5 and TLR9, participate in the induction of immune response against H. pylori. TLR2 is expressed on a number of immune and non-immune cells and recognizes a vast broad of microbial components due to its potential to form heterodimers with other TLRs, including TLR1, TLR6 and TLR10...
April 17, 2017: Life Sciences
https://www.readbyqxmd.com/read/28427781/smoking-increases-the-likelihood-of-helicobacter-pylori-treatment-failure
#3
David Itskoviz, Doron Boltin, Haim Leibovitzh, Tsachi Tsadok Perets, Doron Comaneshter, Arnon Cohen, Yaron Niv, Zohar Levi
BACKGROUND AND AIMS: Data regarding the impact of smoking on the success of Helicobacter pylori (H. pylori) eradication are conflicting, partially due to the fact that sociodemographic status is associated with both smoking and H. pylori treatment success. We aimed to assess the effect of smoking on H. pylori eradication rates after controlling for sociodemographic confounders. METHODS: Included were subjects aged 15 years or older, with a first time positive C(13)-urea breath test (C(13)-UBT) between 2007 to 2014, who underwent a second C(13)-UBT after receiving clarithromycin-based triple therapy...
March 27, 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/28413207/rate-of-active-helicobacter-pylori-infection-among-symptomatic-patients-of-pakistan
#4
F Rasheed, A Yameen, T Ahmad, R Bilal
Only few epidemiological studies have examined the rate of active H. pylori infection in the symptomatic population in Pakistan. This retrospective study presents the laboratory data collected during the past 13 years (2002 to 2015) from 2315 symptomatic patients referred to the BreathMAT Lab, Nuclear Medicine, Oncology and Radiotherapy Institute, Islamabad for the diagnosis of active H. pylori infection using the (13)C Urea Breath Test. Rate of infection and its association with gender and age were evaluated...
April 2017: Malaysian Journal of Pathology
https://www.readbyqxmd.com/read/28413079/mexican-consensus-on-dyspepsia
#5
R Carmona-Sánchez, O Gómez-Escudero, M Zavala-Solares, M V Bielsa-Fernández, E Coss-Adame, A I Hernández-Guerrero, F Huerta-Iga, M E Icaza-Chávez, M A Lira-Pedrín, J A Lizárraga-López, A López-Colombo, A Noble-Lugo, J Pérez-Manauta, R H Raña-Garibay, J M Remes-Troche, J L Tamayo, L F Uscanga, F Zamarripa-Dorsey, M A Valdovinos Díaz, J A Velarde-Ruiz Velasco
Since the publication of the 2007 dyspepsia guidelines of the Asociación Mexicana de Gastroenterología, there have been significant advances in the knowledge of this disease. A systematic search of the literature in PubMed (01/2007 to 06/2016) was carried out to review and update the 2007 guidelines and to provide new evidence-based recommendations. All high-quality articles in Spanish and English were included. Statements were formulated and voted upon using the Delphi method. The level of evidence and strength of recommendation of each statement were established according to the GRADE system...
April 13, 2017: Revista de Gastroenterología de México
https://www.readbyqxmd.com/read/28410791/gastrointestinal-safety-of-celecoxib-versus-naproxen-in-patients-with-cardiothrombotic-diseases-and-arthritis-after-upper-gastrointestinal-bleeding-concern-an-industry-independent-double-blind-double-dummy-randomised-trial
#6
Francis K L Chan, Jessica Y L Ching, Yee Kit Tse, Kelvin Lam, Grace L H Wong, Siew C Ng, Vivian Lee, Kim W L Au, Pui Kuan Cheong, Bing Y Suen, Heyson Chan, Ka Man Kee, Angeline Lo, Vincent W S Wong, Justin C Y Wu, Moe H Kyaw
BACKGROUND: Present guidelines are conflicting for patients at high risk of both cardiovascular and gastrointestinal events who continue to require non-steroidal anti-inflammatory drugs (NSAIDs). We hypothesised that a cyclooxygenase-2-selective NSAID plus proton-pump inhibitor is superior to a non-selective NSAID plus proton-pump inhibitor for prevention of recurrent ulcer bleeding in concomitant users of aspirin with previous ulcer bleeding. METHODS: For this industry-independent, double-blind, double-dummy, randomised trial done in one academic hospital in Hong Kong, we screened patients with arthritis and cardiothrombotic diseases who were presenting with upper gastrointestinal bleeding, were on NSAIDs, and require concomitant aspirin...
April 11, 2017: Lancet
https://www.readbyqxmd.com/read/28410586/efficacy-and-safety-of-jianzhong-decoction-in-treating-peptic-ulcers-a-meta-analysis-of-58-randomised-controlled-trials-with-5192-patients
#7
Yan Sun, Jinping Zhang, Yuanyuan Chen
BACKGROUND: Jianzhong decoction is widely used to treat peptic ulcers; however, due to lack of systematic evaluations, its clinical efficacy remains controversial. We performed meta-analysis to evaluate the efficacy and safety of Jianzhong decoction in treating peptic ulcers. METHODS: Studies were systematically retrieved from PubMed, Embase, Cochrane library, China National Knowledge Infrastructure, Wanfang Database, Chongqing VIP, China Biology Medicine disc (CBMdisc), and references cited in related studies/reviews...
April 14, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28408993/real-world-helicobacter-pylori-diagnosis-in-patients-referred-for-esophagoduodenoscopy-the-gap-between-guidelines-and-clinical-practice
#8
Dor Shirin, Shay Matalon, Benjamin Avidan, Efrat Broide, Haim Shirin
BACKGROUND AND AIMS: Histopathology is the most accurate test to detect H. pylori when performed correctly with unknown validity in daily practice clinic settings. We aimed to determine the rate of potentially false-negative H. pylori results that might be due to continued use of proton pump inhibitors (PPIs) in routine endoscopy practice. We also aimed to establish whether gastroenterologists recommend routine cessation of PPIs before esophagogastroduodenoscopy (EGD) and whether they regularly document that biopsies for H...
December 2016: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/28408943/effectiveness-of-citrus-fruits-on-helicobacter-pylori
#9
REVIEW
Giuseppina Mandalari, Carlo Bisignano, Santa Cirmi, Michele Navarra
It is known that Helicobacter pylori infection is associated with chronic gastritis, peptic ulcer, and gastric carcinoma. Due to the increased side effects of the treatment regimens and the development of antimicrobial resistance, a number of natural compounds have been tested as potential alternatives. In this review, we will examine the current knowledge on the effect of Citrus fruits and their derivatives against H. pylori, highlighting the remaining outstanding questions on the development of novel therapeutic strategies...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28407007/polaprezinc-combined-with-clarithromycin-based-triple-therapy-for-helicobacter-pylori-associated-gastritis-a-prospective-multicenter-randomized-clinical-trial
#10
RANDOMIZED CONTROLLED TRIAL
Bei Tan, Han-Qing Luo, Hong Xu, Nong-Hua Lv, Rui-Hua Shi, He-Sheng Luo, Jian-Sheng Li, Jian-Lin Ren, Yi-You Zou, Yan-Qing Li, Feng Ji, Jing-Yuan Fang, Jia-Ming Qian
The efficacy and safety of polaprezinc combined with triple therapy was compared with triple therapy alone in the eradication of Helicobacter pylori. A randomized, parallel-group, open-label, controlled, prospective multicenter study was conducted in 11 cities in China. Treatment-naive patients with H. pylori-associated gastritis were randomly assigned to one of three arms for a 14-day treatment: Arm A triple therapy (omeprazole 20 mg, amoxicillin 1 g, and clarithromycin 500 mg, each twice daily) plus polaprezinc 75 mg twice daily; Arm B triple therapy plus polaprezinc 150 mg twice daily, or Arm C triple therapy alone...
2017: PloS One
https://www.readbyqxmd.com/read/28406585/association-of-helicobacter-pylori-with-parkinson-s-disease
#11
Kandadai Rukmini Mridula, Rupam Borgohain, Vupparalli Chandrasekhar Reddy, Venkata Chandrasekhar Srinivasarao Bandaru, Turaga Suryaprabha
BACKGROUND AND PURPOSE: Parkinson's disease (PD) is a major neurological disorder that requires lifelong treatment, and the combined presence of Helicobacter pylori (H. pylori) infection can increase the required anti-PD medications. We aim to investigate the effect of H. pylori infection in Indian PD patients. METHODS: We prospectively recruited 36 PD patients from December 2007 to January 2011. All patients underwent a detailed neurological evaluation and serological examination for H...
April 2017: Journal of Clinical Neurology
https://www.readbyqxmd.com/read/28400819/the-role-of-endoscopic-ultrasound-in-the-diagnosis-and-management-of-primary-gastric-lymphoma
#12
REVIEW
Dimitrios Schizas, Ioannis Ntanasis-Stathopoulos, Diamantis I Tsilimigras, Athanasios D Sioulas, Demetrios Moris, Eleftherios Spartalis, Ilias Scotiniotis, Ioannis S Papanikolaou
Endoscopic ultrasound (EUS) is considered a valuable diagnostic tool during the workup of malignant gastric lesions, including primary gastric lymphomas (PGL). Although endoscopy combined with multiple biopsies remains essential in the establishment of PGL diagnosis, EUS utilization in locoregional disease staging has been well documented in the literature. Data also support the possible role of EUS in prediction of response to first-line treatment, that is, Helicobacter pylori eradication. However, its application in the posttreatment setting remains problematic, since concordance rates between endosonography and histology findings during follow-up seem to vary substantially...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/28399347/conjunctival-tumors-review-of-clinical-features-risks-biomarkers-and-outcomes-the-2017-j-donald-m-gass-lecture
#13
Carol L Shields, Jason L Chien, Thamolwan Surakiatchanukul, Kareem Sioufi, Sara E Lally, Jerry A Shields
Conjunctival tumors encompass a broad range of diagnoses. The 3 most important malignant tumors include ocular surface squamous neoplasia (OSSN) (14%), melanoma (12%), and lymphoma (7%). Conjunctival malignancies are rarely found in children. Regarding OSSN, pre-disposing conditions include chronic solar radiation, immune deficiency (HIV), organ transplant, autoimmune conditions, xeroderma pigmentosum, and chronic exposure to cigarette smoke. OSSN is managed surgically or with topical/injection immunotherapy or chemotherapy...
March 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/28393827/-possibilities-for-optimization-of-eradication-therapy-for-helicobacter-pylori-infection-in-modern-clinical-practice
#14
D N Andreev, D T Dicheva, I V Maev
A steady decline in the effectiveness of standard eradication therapy (ET) regimens for Helicobacter pylori infection necessitates a search for ways of their optimization, by enhancing the efficiency of treatment protocols and by improving their safety and tolerability. The review systematizes the data available in the literature on main accessible methods for optimizing ET regimens. Among the optimization methods that can considerably enhance the efficiency of ET regimens, one may identify their addition of a bismuth agent (by 10-20%), the use of rebamipide (by 11...
2017: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/28391418/randomized-clinical-trial-esomeprazole-bismuth-levofloxacin-and-amoxicillin-or-cefuroxime-as-first-line-eradication-regimens-for-helicobacter-pylori-infection
#15
Wei Fu, Zhiqiang Song, Liya Zhou, Yan Xue, Yu Ding, Baojun Suo, Xueli Tian, Li Wang
BACKGROUND: The eradication of Helicobacter pylori infection remains a challenge, especially in the patients unsuitable to take penicillin. Cephalosporin has the potential to replace amoxicillin for H. pylori eradication. AIMS: To compare the effectiveness, safety, and compliance of amoxicillin- and cefuroxime-containing quadruple regimens in treatment-naïve patients. METHODS: In this open-label randomized control study, 400 patients with H...
April 8, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28386474/finding-novel-antibiotic-substances-from-medicinal-plants-antimicrobial-properties-of-nigella-sativa-directed-against-multidrug-resistant-bacteria
#16
Seher Nancy Bakal, Stefan Bereswill, Markus M Heimesaat
The progressive rise in multidrug-resistant (MDR) bacterial strains poses serious problems in the treatment of infectious diseases. While the number of newly developed antimicrobial compounds has greatly fallen, the resistance of pathogens against commonly prescribed drugs is further increasing. This rise in resistance illustrates the need for developing novel therapeutic and preventive antimicrobial options. The medicinal herb Nigella sativa and its derivatives constitute promising candidates. In a comprehensive literature survey (using the PubMed data base), we searched for publications on the antimicrobial effects of N...
March 2017: European Journal of Microbiology & Immunology
https://www.readbyqxmd.com/read/28385468/approach-attitudes-and-knowledge-of-general-practitioners-in-relation-to-helicobacter-pylori-is-inadequate-there-is-much-room-for-improvement
#17
A D Cano-Contreras, O Rascón, M Amieva-Balmori, S Ríos-Gálvez, Y J Maza, A Meixueiro-Daza, F Roesch-Dietlen, J M Remes-Troche
BACKGROUND: Helicobacter pylori (Hp) infection is one of the most common infections in humans. Due to its worldwide prevalence, a series of guidelines and recommendations has been developed for the appropriate screening, diagnosis, and management of patients with Hp infection. AIM: To evaluate the approach, attitudes, and knowledge of a group of Mexican general practitioners in relation to Hp. MATERIALS AND METHODS: A cross-sectional study was conducted that evaluated the knowledge of Hp diagnosis and treatment through the application of a questionnaire...
April 3, 2017: Revista de Gastroenterología de México
https://www.readbyqxmd.com/read/28384920/dissimilar-pain-of-primary-epiploic-appendagitis-and-malabsorption
#18
Wolfgang J Schnedl, Dietmar Enko, Sandra J Wallner-Liebmann, Sonja Lackner, Harald Mangge
Primary Epiploic Appendagitis (PEA) is a rare cause of acute or subacute abdominal complaints and non-migratory pain. Usually the diagnosis of PEA is made when Computed Tomography (CT) reveals characteristic figures. Nonspecific abdominal complaints including diffuse abdominal pain may be caused by carbohydrate and/or protein malabsorption. We report a case of a patient with PEA who recovered without medication or surgical treatment within a few days. Eight months later, he was diagnosed with lactose- and histamine malabsorption and Helicobacter pylori infection...
February 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28374931/a-link-between-platelet-to-lymphocyte-ratio-and-helicobacter-pylori-infection
#19
Raymond Farah, Hamza Hamza, Rola Khamisy-Farah
PURPOSE: Chronic Helicobacter pylori gastritis affects two-thirds of the world's population and is one of the most common chronic inflammatory disorders of humans, the infection clearly results in chronic mucosal inflammation in the stomach and duodenum, which, in turn, might lead to abnormalities in gastroduodenal motility and sensitivity and is the most frequent cause of dyspepsia and peptic disease. Some studies showed that there was a correlation between low-grade inflammation as CRP and HP infection...
April 4, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/28373764/effect-of-treatment-failure-on-the-caga-epiya-motif-in-helicobacter-pylori-strains-from-colombian-subjects
#20
Javier Andres Bustamante-Rengifo, Andres Jenuer Matta, Alvaro Jairo Pazos, Luis Eduardo Bravo
AIM: To evaluate effect of treatment failure on cagA and vacA genotypes in Helicobacter pylori (H. pylori) isolates from Colombia. METHODS: One hundred and seventy-six participants infected with H. pylori from Colombia were treated during 14 d with the triple-standard therapy. Six weeks later, eradication was evaluated by (13)C-Urea breath test. Patients with treatment failure were subjected to endoscopy control; biopsies obtained were used for histopathology and culture...
March 21, 2017: World Journal of Gastroenterology: WJG
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