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https://www.readbyqxmd.com/read/29144559/treatment-of-helicobacter-pylori-infection-a-clinical-practice-update
#1
REVIEW
Rocco Maurizio Zagari, Stefano Rabitti, Leonardo Henry Eusebi, Franco Bazzoli
BACKGROUND: Helicobacter pylori infection is still frequent in the community and all infected subjects should be offered an eradication therapy. Nowdays physicians have to face the challenge of antibiotic resistance in treating Helicobacter pylori infected individuals. AIM: This review provides an overview of current international guidelines and reports recent evidence from systematic reviews and clinical trials on the treatment of Helicobacter pylori infection, and should help physicians to better treat their patients...
November 16, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29138645/chinese-classical-formula-sijunzi-decoction-and-chronic-atrophic-gastritis-evidence-for-treatment-approach
#2
REVIEW
Danan Gan, Aili Xu, Hongbo Du, Yong'an Ye
Objective: This aim is to evaluate the effect of Sijunzi decoction (SJZD) treating chronic atrophic gastritis (CAG). Methods: We performed searches in seven databases. The randomized controlled trials (RCTs) comparing SJZD with standard medical care or inactive intervention for CAG were enrolled. Combined therapy of SJZD plus conventional therapies compared with conventional therapies alone was also retrieved. The primary outcome included the incidence of gastric cancer and the improvement of atrophy, intestinal metaplasia, and dysplasia based on the gastroscopy and pathology...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29138101/primary-antibiotic-resistance-of-helicobacter-pylori-in-chinese-patients-a-multi-region-prospective-7-year-study
#3
Dong-Sheng Liu, You-Hua Wang, Zhi-Rong Zeng, Zhen-Yu Zhang, Hong Lu, Jian-Ming Xu, Yi-Qi Du, Yan Li, Jiang-Bin Wang, San-Ping Xu, Ye Chen, Chun-Hui Lan, Hong Cheng, Ming-de Jiang, Ling-Xia Zhang, Li-Juan Huo, Shi-Yao Chen, Guo-Xin Zhang, Kai-Chun Wu, Xuan Zhu, You-Xiang Chen, Yin Zhu, Xu Shu, Yong Xie, Nong-Hua Lu
OBJECTIVES: To explore the characteristics of H. pylori resistance in China and the association between antibiotic resistance and several clinical factors. METHODS: H. pylori strains were collected from patients in 13 provinces/cities in China between 2010 and 2016. Demographic data including type of disease, geographic area, age, gender and isolation year were collected to analyse their association with antibiotic resistance. Antibiotic resistance was detected using the Epsilometer test and the Kirby-Bauer disk diffusion method...
November 11, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29136948/gastroprotective-effect-and-mode-of-action-of-methanol-extract-of-sphenodesme-involucrata-var-paniculata-c-b-clarke-munir-lamiaceae-leaves-on-experimental-gastric-ulcer-models
#4
Puthanpura Sasidharan Sreeja, Karuppusamy Arunachalam, Sathyanarayanan Saikumar, Muniyandi Kasipandi, Sivaraj Dhivya, Rajan Murugan, Thangaraj Parimelazhagan
Sphenodesme involucrata var. paniculata (C. B. Clarke) Munir, endemic to South Asia, is used by tribal for alleviation from abdominal disorders, inflammation and body pain. However, the gastroprotective properties of this species have not yet been studied. The leaves of S. involucrata were extracted by Soxhlet extraction using different solvents successively and the extracts were analyzed for antioxidant and anti-Helicobacter pylori activities using different in vitro assays. The chemical composition of methanol extract of S...
November 9, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29133755/analysis-of-the-relationship-between-helicobacter-pylori-infection-and-diabetic-gastroparesis
#5
Ju Huang
BACKGROUND: Whether Helicobacter pylori infection is associated with diabetic gastroparesis (DGP) is unclear. This study aimed to investigate the potential correlation between H. pylori infection and DGP. METHODS: In this study, 163 patients with type 2 diabetes mellitus and 175 nondiabetic patients who were treated in our department were divided into DGP, simple diabetes, non-DGP (NDG), and normal groups based on their conditions. The H. pylori infection rate in each group was calculated...
November 20, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/29133389/selective-killing-of-helicobacter-pylori-with-ph-responsive-helix-coil-conformation-transitionable-antimicrobial-polypeptides
#6
Menghua Xiong, Yan Bao, Xin Xu, Hua Wang, Zhiyuan Han, Zhiyu Wang, Yeqing Liu, Songyin Huang, Ziyuan Song, Jinjing Chen, Richard M Peek, Lichen Yin, Lin-Feng Chen, Jianjun Cheng
Current clinical treatment of Helicobacter pylori infection, the main etiological factor in the development of gastritis, gastric ulcers, and gastric carcinoma, requires a combination of at least two antibiotics and one proton pump inhibitor. However, such triple therapy suffers from progressively decreased therapeutic efficacy due to the drug resistance and undesired killing of the commensal bacteria due to poor selectivity. Here, we report the development of antimicrobial polypeptide-based monotherapy, which can specifically kill H...
November 13, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29132551/vonoprazan-treatment-improves-gastrointestinal-symptoms-in-patients-with-gastroesophageal-reflux-disease
#7
Satoshi Shinozaki, Hiroyuki Osawa, Yoshikazu Hayashi, Hirotsugu Sakamoto, Yoshimasa Miura, Alan Kawarai Lefor, Hironori Yamamoto
The effects of vonoprazan, a new potassium-competitive acid blocker, on gastroesophageal reflux disease (GERD) symptom are not fully elucidated. The aim of this study is to determine the effect of vonoprazan on GERD and associated gastrointestinal symptoms. We retrospectively reviewed 88 Helicobacter pylori negative patients with GERD treated with vonoprazan 10 mg daily. Symptoms were evaluated using the Izumo scale, which reflects quality of life related to various abdominal symptoms. The rates of improvement and resolution of GERD symptoms were 86% (76/88) and 57% (50/88), respectively...
December 2017: Kaohsiung Journal of Medical Sciences
https://www.readbyqxmd.com/read/29119724/evaluation-of-first-line-bismuth-containing-7-day-concomitant-quintuple-therapy-for-helicobacter-pylori-eradication
#8
Jianfang Ye, Junbo Hong, Yin Zhu, Yong Xie, Xu Shu, Lingyu Luo, Chuan Xie, Zhenhua Zhu, Nonghua Lu
BACKGROUND: Helicobacter pylori infection is difficult to cure, mainly due to antibiotic resistance. We performed a trial to determine the efficacy and safety of a bismuth-containing 7-day concomitant quintuple regimen for the eradication of H. pylori. METHODS: Conducted from August 2015 to February 2016 at First Affiliated Hospital of Nanchang University, this prospective trial enrolled 70 untreated H. pylori-positive patients. Patients received 7-day quintuple therapy consisting of bismuth subcitrate 220 mg, esomeprazole 20 mg, clarithromycin 500 mg, amoxicillin 1 g, and metronidazole 400 mg, each twice daily...
November 9, 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/29118570/helicobacter-pylori-best-treatment-approach-should-a-national-consensus-be-the-best-consensus
#9
Christos Liatsos, Sotirios D Georgopoulos
No abstract text is available yet for this article.
2017: Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology
https://www.readbyqxmd.com/read/29110085/safety-of-first-line-triple-therapy-with-a-potassium-competitive-acid-blocker-for-helicobacter-pylori-eradication-in-children
#10
Chika Kusano, Takuji Gotoda, Sho Suzuki, Hisatomo Ikehara, Mitsuhiko Moriyama
BACKGROUND: Helicobacter pylori infection is a risk factor for gastric cancer, and it has been reported that eradication of H. pylori is effective for preventing such cancer. Recently, H. pylori eradication has been performed in children as first-line therapy against gastric cancer. Here, we report use of triple therapy with a potassium-competitive acid blocker (P-CAB) for H. pylori eradication in children. METHODS: H. pylori infection testing and eradication therapy began in fiscal year 2015 in junior high school students located in Yurihonjo city and Nikaho city, Akita prefecture, Japan...
November 7, 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/29109345/-analysis-of-the-gray-zone-cutoff-values-of-new-serum-helicobacter-pylori-antibody-kits-using-latex-immunoassay
#11
Masayuki Inui, Susumu Ohwada, Yoshikatsu Inui, Yuko Kondo
The serum Helicobacter pylori titers are good markers for population-based H. pylori screening and treatment programs because the tests used to estimate these titers are noninvasive, inexpensive, and convenient. However, the reference range of 3-10U/mL, which is used as a standard in commercially available serum H. pylori antibody kit E plate Eiken H. pylori antibody II, is regarded as a gray-zone cutoff value to indicate H. pylori infection status. We aimed to clarify the gray-zone cutoff values of H. pylori infection status with new serum H...
2017: Nihon Shokakibyo Gakkai Zasshi, the Japanese Journal of Gastro-enterology
https://www.readbyqxmd.com/read/29103130/in-vitro-antimicrobial-activity-and-downregulation-of-virulence-gene-expression-on-helicobacter-pylori-by-reuterin
#12
Víctor Hugo Urrutia-Baca, Erandi Escamilla-García, Myriam Angélica de la Garza-Ramos, Patricia Tamez-Guerra, Ricardo Gomez-Flores, Cynthia Sofía Urbina-Ríos
Helicobacter pylori is an infectious agent commonly associated with gastrointestinal diseases. The use of probiotics to treat this infection has been documented, however, their potential antimicrobial metabolites have not yet been investigated. In the present study, the effect of reuterin produced by Lactobacillus reuteri on H. pylori growth and virulence gene expression was evaluated. It was observed that reuterin caused significant (P < 0.05) H. pylori growth inhibition at concentrations from 0.08 to 20...
November 4, 2017: Probiotics and Antimicrobial Proteins
https://www.readbyqxmd.com/read/29102269/assessment-of-the-use-of-vitamin-c-and-e-supplements-concomitantly-to-antibiotic-treatment-against-helicobacter-pylori-a-systematic-review-and-meta-analysis
#13
Edgar Yaset Caicedo Ochoa, César Orlando Quintero Moreno, Yardany Rafael Méndez Fandiño, Sofía Catalina Sánchez Fonseca, Héctor Fabio Cortes Motta, Santiago Alejandro Guio Guerra
INTRODUCTION: Helicobacter pylori infections affect almost 50% of the world population, constituting a risk factor for benign and malignant gastrointestinal diseases. The increased resistance to antibiotic treatment against this infection represents a dilemma in the search of other therapeutic alternatives. OBJECTIVE: To determine the efficacy of the use of vitaminC and E supplements concomitantly to antibiotic treatment against H. pylori infections. METHODS: We performed a systematic review on the MedLine (PubMed), Embase and Cochrane Central Register of Clinical Trials (CENTRAL) databases, searching for studies evaluating the efficacy of vitaminC and/or E supplements in the antibiotic treatment of H...
November 1, 2017: Medicina Clínica
https://www.readbyqxmd.com/read/29094477/rescue-therapy-with-bismuth-quadruple-regimen-in-patients-with-helicobacter-pylori-resistant-strains
#14
Giulia Fiorini, Ilaria Maria Saracino, Angelo Zullo, Luigi Gatta, Matteo Pavoni, Dino Vaira
BACKGROUND: Bismuth quadruple therapy (BQT) is the recommended rescue therapy for Helicobacter pylori (H. pylori) infection. This study aimed to assess the efficacy and safety of a 10-day BQT regimen in patients who failed previous therapies and were infected with multiresistant H. pylori strains MATERIALS AND METHODS: Helicobacter pylori-infected patients underwent endoscopy, culture, and susceptibility test for clarithromycin, metronidazole, and levofloxacin. Treatment with three-in-one capsule (Pylera®) four times daily and esomeprazole 20 mg twice daily for 10 days was administered...
November 1, 2017: Helicobacter
https://www.readbyqxmd.com/read/29093241/national-consensus-on-management-of-dyspepsia-and-helicobacter-pylori-infection
#15
Ari F Syam, Marcellus Simadibrata, Dadang Makmun, Murdani Abdullah, Achmad Fauzi, Kaka Renaldi, Hasan Maulahela, Amanda P Utari
Dyspepsia is one of numerous general complaints, which is commonly encountered by doctors of various disciplines. In daily practice, the complaint is not only limited for gastroenterologists. Knowledge on pathophysiology of dyspepsia have been developing continuously since a scientific investigation has been started in 1980's, which considers Helicobacter pylori as one of key factor in managing dyspepsia, either it is associated with ulcer or non-ulcer. The management of dyspepsia cannot be separated from the management of H...
July 2017: Acta Medica Indonesiana
https://www.readbyqxmd.com/read/29089382/long-term-proton-pump-inhibitors-and-risk-of-gastric-cancer-development-after-treatment-for-helicobacter-pylori-a-population-based-study
#16
Ka Shing Cheung, Esther W Chan, Angel Y S Wong, Lijia Chen, Ian C K Wong, Wai Keung Leung
OBJECTIVE: Proton pump inhibitors (PPIs) is associated with worsening of gastric atrophy, particularly in Helicobacter pylori (HP)-infected subjects. We determined the association between PPIs use and gastric cancer (GC) among HP-infected subjects who had received HP therapy. DESIGNS: This study was based on a territory-wide health database of Hong Kong. We identified adults who had received an outpatient prescription of clarithromycin-based triple therapy between year 2003 and 2012...
October 31, 2017: Gut
https://www.readbyqxmd.com/read/29083538/functional-dyspepsia-and-duodenal-eosinophilia-a-new-disease-model
#17
REVIEW
Kening Fan, Nicholas J Talley
Functional dyspepsia (FD) is a highly prevalent disorder that affects more than 10% of the population. In the past decade, the conceptual underpinning of FD has begun to change, and new data are unraveling the underlying pathophysiological mechanisms of this disorder with a focus on the duodenum. The Rome IV criteria were published in 2016, and notably suggests that gastroesophageal reflux disease and irritable bowel syndrome may all be part of the same disease spectrum as FD. Helicobacter pylori explains a minority of FD cases and in Rome IV is considered a separate entity...
October 30, 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/29080461/l-ascorbic-acid-2-glucoside-inhibits-helicobacter-pylori-induced-apoptosis-through-mitochondrial-pathway-in-gastric-epithelial-cells
#18
Xiong Chen, Rui Liu, Xiaoming Liu, Canxia Xu, Xiaoyan Wang
Helicobacter pylori (H. pylori) infection is the major cause for gastritis, peptic ulcer, and gastric cancer. Elevated oxidative stress, mitochondrial dysfunction and apoptotic death of gastric epithelial cells are typical hallmarks of H. pylori infection. Ascorbic Acid 2-Glucoside (AA2G) is a stable version of Vitamin C, that binds glucose to conventional vitamin C. AA2G has free radical scavenging activities and anti-apoptotic abilities. However, the protective effect of AA2G against H. pylori-infection in gastric epithelial cells is yet unknown...
October 25, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29076008/cumulative-helicobacter-pylori-eradication-rates-by-adopting-first-and-second-line-regimens-proposed-by-the-maastricht-iv-consensus-in-obese-patients-undergoing-gastric-bypass-surgery
#19
Rute M Cerqueira, M Correia, H Vilar, M C Manso
AIMS AND METHODS: Our aim was to assess, in obese patients undergoing Roux-en-Y gastric bypass (RYGB) surgery, the cumulative Helicobacter pylori (HP) eradication rates by adopting Maastricht IV guidelines in areas of high clarithromycin resistance rates (CLT)-14 days concomitant first-line therapy with proton-pump inhibitor (PPI) bid, CLT 500 mg bid, metronidazole (MTZ) 500 bid, and amoxicillin (AMX) 1000 mg bid and 14 days second-line therapy with PPI bid, AMX 1000 mg bid and levofloxacin (LVF) 500 mg od...
October 26, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/29075827/helicobacter-pylori-treatment-antibiotics-or-probiotics
#20
REVIEW
Kamila Goderska, Sonia Agudo Pena, Teresa Alarcon
Treatment of Helicobacter pylori infection is important for the management of gastrointestinal disorders such as peptic ulcer and gastric cancer. Due to the increase in the prevalence of H. pylori resistance to antibiotics, triple therapy with clarithromycin is no longer the best treatment for H. pylori, especially in some areas where the local resistance to this antibiotic is higher than 20%. Alternative treatments have been proposed for the eradication of H. pylori. Some of them including novel antibiotics or classical ones in different combinations; these treatments are being used in the regular clinical practice as novel and more effective treatments...
October 26, 2017: Applied Microbiology and Biotechnology
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