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acclimatization to high altitude

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https://www.readbyqxmd.com/read/28640969/control-of-breathing-and-ventilatory-acclimatization-to-hypoxia-in-deer-mice-native-to-high-altitudes
#1
Catherine M Ivy, Graham R Scott
AIM: We compared the control of breathing and heart rate by hypoxia between high- and low-altitude populations of Peromyscus mice, to help elucidate the physiological specializations that help high-altitude natives cope with O2 limitation. METHODS: Deer mice (P. maniculatus) native to high altitude and congeneric mice native to low altitude (P. leucopus) were bred in captivity at sea level. The F1 progeny of each population were raised to adulthood and then acclimated to normoxia or hypobaric hypoxia (12 kPa, simulating hypoxia at ~4300 m) for 5 months...
June 22, 2017: Acta Physiologica
https://www.readbyqxmd.com/read/28590162/exercise-testing-supplemental-oxygen-and-hypoxia
#2
Susan A Ward, Michael Pw Grocott, Denny Zh Levett
Cardiopulmonary exercise testing (CPET) in hyperoxia and hypoxia has several applications, stemming from characterization of abnormal physiological response profiles associated with exercise intolerance. As altered oxygenation can impact on the performance of gas-concentration and flow sensors and pulmonary gas exchange algorithms, integrated CPET system function requires validation under these conditions. Also, as oxygenation status can influence peak O2 uptake, care should be taken in the selection of work-rate incrementation rates when CPET performance is to be compared with sea-level...
June 7, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28506292/normobaric-hypoxia-overnight-impairs-cognitive-reaction-time
#3
Stephan Pramsohler, Stefan Wimmer, Martin Kopp, Hannes Gatterer, Martin Faulhaber, Martin Burtscher, Nikolaus Cristoph Netzer
BACKGROUND: Impaired reaction time in patients suffering from hypoxia during sleep, caused by sleep breathing disorders, is a well-described phenomenon. High altitude sleep is known to induce periodic breathing with central apneas and oxygen desaturations, even in perfectly healthy subjects. However, deficits in reaction time in mountaineers or workers after just some nights of hypoxia exposure are not sufficiently explored. Therefore, we aimed to investigate the impact of sleep in a normobaric hypoxic environment on reaction time divided by its cognitive and motoric components...
May 15, 2017: BMC Neuroscience
https://www.readbyqxmd.com/read/28486083/progress-in-mass-spectrometry-based-proteomics-in-hypoxia-related-diseases-and-high-altitude-medicine
#4
Zhiqi Gao, Gang Luo, Bing Ni
Human migration, influenced by social conflict and natural disasters as well as global climate change, has become recognized as a major "planetary force." It has also brought to the forefront, new specialties of integrative biology-such as high-altitude medicine-and the impact of hitherto understudied environmental factors on human pathophysiology in these new geographical settings. For people migrating to or living in high-altitude regions, environmental hypoxia is a primary challenge. Decreased partial pressure of oxygen in environmental air, caused by lower barometric pressure, puts living organisms in a hypoxic state...
June 2017: Omics: a Journal of Integrative Biology
https://www.readbyqxmd.com/read/28486037/role-of-arcuate-nucleus-in-the-regulation-of-feeding-behavior-in-the-process-of-altitude-acclimatization-in-rats
#5
Xiang-Wen Liu, Jie Yin, Qi-Sheng Ma, Chu-Chu Qi, Ji-Ying Mu, Lang Zhang, Li-Ping Gao, Yu-Hong Jing
Liu, Xiang-Wen, Jie Yin, Qi-Sheng Ma, Chu-Chu Qi, Ji-Ying Mu, Lang Zhang, Li-Ping Gao, and Yu-Hong Jing. Role of arcuate nucleus in the regulation of feeding behavior in the process of altitude acclimatization in rats. High Alt Med Biol. 00:000-000, 2017.-Highly efficient energy utilization and metabolic homeostasis maintenance rely on neuromodulation. Altitude exposure is known to stimulate neuroendocrine systems to respond to acute hypoxia and adaptive acclimatization. However, limited data on how the adaptive regulation of the arcuate nucleus performs in the process of altitude acclimatization are available...
May 9, 2017: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/28453332/long-term-intermittent-exposure-to-high-altitude-elevates-asymmetric-dimethylarginine-in-first-exposed-young-adults
#6
Nicole Lüneburg, Patricia Siques, Julio Brito, Juan José De La Cruz, Fabiola León-Velarde, Juliane Hannemann, Cristian Ibanez, Rainer H Böger
Lüneburg, Nicole, Patricia Siques, Julio Brito, Juan José De La Cruz, Fabiola León-Velarde, Juliane Hannemann, Cristian Ibanez, and Rainer Böger. Long-term intermittent exposure to high altitude elevates asymmetric dimethylarginine in first exposed young adults. High Alt Med Biol 00:000-000, 2017.-Hypoxia-induced dysregulation of pulmonary and cerebral circulation may be related to an impaired nitric oxide (NO) pathway. We investigated the effect of chronic intermittent hypobaric hypoxia (CIH) on metabolites of the NO pathway...
April 28, 2017: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/28418725/medex-2015-heart-rate-variability-predicts-development-of-acute-mountain-sickness
#7
Angus Sutherland, Joseph Freer, Laura Evans, Alberto Dolci, Matteo Crotti, Jamie Hugo Macdonald
Sutherland, Angus, Joseph Freer, Laura Evans, Alberto Dolci, Matteo Crotti, and Jamie Hugo Macdonald. MEDEX 2015: Heart rate variability predicts development of acute mountain sickness. High Alt Med Biol 00:000-000, 2017. AIMS: Acute mountain sickness (AMS) develops when the body fails to acclimatize to atmospheric changes at altitude. Preascent prediction of susceptibility to AMS would be a useful tool to prevent subsequent harm. Changes to peripheral oxygen saturation (SpO2) on hypoxic exposure have previously been shown to be of poor predictive value...
April 18, 2017: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/28389828/cross-adaptation-heat-and-cold-adaptation-to-improve-physiological-and-cellular-responses-to-hypoxia
#8
REVIEW
Oliver R Gibson, Lee Taylor, Peter W Watt, Neil S Maxwell
To prepare for extremes of heat, cold or low partial pressures of oxygen (O2), humans can undertake a period of acclimation or acclimatization to induce environment-specific adaptations, e.g. heat acclimation (HA), cold acclimation (CA), or altitude training. While these strategies are effective, they are not always feasible due to logistical impracticalities. Cross-adaptation is a term used to describe the phenomenon whereby alternative environmental interventions, e.g. HA or CA, may be a beneficial alternative to altitude interventions, providing physiological stress and inducing adaptations observable at altitude...
April 7, 2017: Sports Medicine
https://www.readbyqxmd.com/read/28375664/effects-of-short-term-acclimatization-at-the-summit-of-mt-fuji-3776%C3%A2-m-on-sleep-efficacy-cardiovascular-responses-and-ventilatory-responses
#9
Masahiro Horiuchi, Shiro Oda, Tadashi Uno, Junko Endo, Yoko Handa, Yoshiyuki Fukuoka
Horiuchi, Masahiro, Shiro Oda, Tadashi Uno, Junko Endo, Yoko Handa, and Yoshiyuki Fukuoka. Effects of short-term acclimatization at the summit of Mt. Fuji (3776 m) on sleep efficacy, cardiovascular responses, and ventilatory responses. High Alt Med Biol. 18:171-178, 2017.-We investigated the effects of a short period of acclimatization, at 3776 m on Mt. Fuji, on sleep parameters and related physiological responses. Physiological responses were assessed in seven healthy lowlander men during both daytime and sleep while at sea level (SL), as well as for three consecutive nights at high altitude (HA; 3776 m, day 1 [D1], D2, D3, and morning only of D4)...
June 2017: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/28372260/preliminary-investigation-for-effects-of-hypothalamic-leptin-ghrelin-and-arcuate-nucleus-pro-opiomelanocortin-system-on-regulation-of-high-altitude-acclimatization
#10
Yong-Nian Liu, Qi-Sheng Ma, Qiong Wu
This study aims to investigate the mechanism of hypothalamic Leptin/Ghrelin and arcuate nucleus pro-opiomelanocortin (POMC) system in the regulation of high-altitude acclimatization. SD rats (male) were divided into two groups and separately fed at the 2260m and 4700m altitude. Tow groups contained 5 small groups separately, including 1 d, 3 d, 7 d, 15 d and 30 d, and 8 rats in each group. Blood, cerebrospinal fluid and tissues were taken at setting time. Leptin and Ghrelin were detected by using radioactivity immuno-assay...
May 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28370674/reduced-blood-flow-through-intrapulmonary-arteriovenous-anastomoses-during-exercise-in-lowlanders-acclimatizing-to-high-altitude
#11
Lindsey M Boulet, Andrew T Lovering, Michael M Tymko, Trevor A Day, Mike Stembridge, Trang Anh Nguyen, Philip N Ainslie, Glen E Foster
What is the central question of this study? The aim was to determine, using the technique of agitated saline contrast echocardiography, whether exercise after 4-7 days at 5050 m would affect blood flow through intrapulmonary arteriovenous anastomoses (Q̇IPAVA) compared with exercise at sea level. What is the main finding and its importance? Despite a significant increase in both cardiac output and pulmonary pressure during exercise at high altitude, there is very little Q̇IPAVA at rest or during exercise after 4-7 days of acclimatization...
March 30, 2017: Experimental Physiology
https://www.readbyqxmd.com/read/28239483/soldiers-load-carriage-performance-in-high-mountains-a-physiological-study
#12
Tirthankar Chatterjee, Debojyoti Bhattacharyya, Anilendu Pramanik, Madhusudan Pal, Deepti Majumdar, Dhurjati Majumdar
BACKGROUND: The present study was designed to evaluate load carriage performance at extremely high altitudes with different loads and walking speeds in terms of physiological evaluation. The degree of maximum oxygen consumption changes at high altitudes was also examined. METHODS: Twelve Indian Army soldiers were acclimatized at altitudes of 3,505 m and 4,300 m. They walked for 10 minutes on a motorized treadmill at 2.5 km/h and 3.5 km/h speeds during carrying no loads and three magnitudes of load (10...
2017: Military Medical Research
https://www.readbyqxmd.com/read/28169986/erythrocytes-retain-hypoxic-adenosine-response-for-faster-acclimatization-upon-re-ascent
#13
Anren Song, Yujin Zhang, Leng Han, Gennady G Yegutkin, Hong Liu, Kaiqi Sun, Angelo D'Alessandro, Jessica Li, Harry Karmouty-Quintana, Takayuki Iriyama, Tingting Weng, Shushan Zhao, Wei Wang, Hongyu Wu, Travis Nemkov, Andrew W Subudhi, Sonja Jameson-Van Houten, Colleen G Julian, Andrew T Lovering, Kirk C Hansen, Hong Zhang, Mikhail Bogdanov, William Dowhan, Jianping Jin, Rodney E Kellems, Holger K Eltzschig, Michael Blackburn, Robert C Roach, Yang Xia
Faster acclimatization to high altitude upon re-ascent is seen in humans; however, the molecular basis for this enhanced adaptive response is unknown. We report that in healthy lowlanders, plasma adenosine levels are rapidly induced by initial ascent to high altitude and achieved even higher levels upon re-ascent, a feature that is positively associated with quicker acclimatization. Erythrocyte equilibrative nucleoside transporter 1 (eENT1) levels are reduced in humans at high altitude and in mice under hypoxia...
February 7, 2017: Nature Communications
https://www.readbyqxmd.com/read/28149350/the-influence-of-high-altitude-acclimatization-on-ventilatory-and-blood-oxygen-saturation-responses-during-normoxic-and-hypoxic-testing
#14
Anton Ušaj, Stojan Burnik
We investigated how acclimatization effects achieved during a high-altitude alpinist expedition influence endurance performance, ventilation ([Formula: see text]) and blood oxygen saturation (SaO2) in normoxic (NOR) and hypoxic conditions (HYP). An incremental testing protocol on a cycle ergometer was used to determine the power output corresponding to the Lactate (PLT) and Ventilatory Threshold (PVT) in NOR and HYP (FiO2=0.13) as indirect characteristics of endurance performance in both conditions. Furthermore, changes in [Formula: see text], SaO2, blood pH and Pco2 were measured at a similar absolute exercise intensity of 180 W in NOR and HYP conditions...
April 1, 2016: Journal of Human Kinetics
https://www.readbyqxmd.com/read/28032333/the-effect-of-%C3%AE-1-adrenergic-blockade-on-post-exercise-brachial-artery-flow-mediated-dilatation-at-sea-level-and-high-altitude
#15
Michael M Tymko, Joshua C Tremblay, Alex B Hansen, Connor A Howe, Chris K Willie, Mike Stembridge, Daniel J Green, Ryan L Hoiland, Prajan Subedi, James D Anholm, Philip N Ainslie
KEY POINTS: Our objective was to quantify endothelial function (via brachial artery flow-mediated dilatation) at sea level (344 m) and high altitude (3800 m) at rest and following both maximal exercise and 30 min of moderate-intensity cycling exercise with and without administration of an α1 -adrenergic blockade. Brachial endothelial function did not differ between sea level and high altitude at rest, nor following maximal exercise. At sea level, endothelial function decreased following 30 min of moderate-intensity exercise, and this decrease was abolished with α1 -adrenergic blockade...
March 1, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28006436/professor-bengt-saltin-symposium-environmental-challenges-to-human-performance
#16
REVIEW
Philip N Ainslie
This short review is from a presentation made at the Bengt Saltin Symposium, October 15-17, at the 2015 Canadian Society for Exercise Physiology conference, Hamilton, Canada. The review provides context of the important work of the late Dr. Saltin's contributions to environmental physiology. In addition to well-controlled laboratory experiments to better understand the influence of hypoxia or temperature, or both, Dr. Saltin also led several field expeditions to the North Greenland, Kenya, Himalayas, and the Andes, where he studied several aspects of human adaptation to environment...
January 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/27994555/physiological-adjustments-and-circulating-microrna-reprogramming-are-involved-in-early-acclimatization-to-high-altitude-in-chinese-han-males
#17
Bao Liu, He Huang, Shou-Xian Wang, Gang Wu, Gang Xu, Bing-Da Sun, Er-Long Zhang, Yu-Qi Gao
Background: Altitude acclimatization is a physiological process that restores oxygen delivery to the tissues and promotes oxygen use under high altitude hypoxia. High altitude sickness occurs in individuals without acclimatization. Unraveling the molecular underpinnings of altitude acclimatization could help understand the beneficial body responses to high altitude hypoxia as well as the altered biological events in un-acclimatized individuals. This study assessed physiological adjustments and circulating microRNA (cmiRNA) profiles in individuals exposed to high altitude, aiming to explore altitude acclimatization in humans...
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/27888818/high-altitude-illness
#18
REVIEW
Anna Hartman-Ksycińska, Jolanta Kluz-Zawadzka, Bogumił Lewandowski
High-altitude illness is a result of prolonged high-altitude exposure of unacclimatized individuals. The illness is seen in the form of acute mountain sickness (AMS) which if not treated leads to potentially life-threatening high altitude pulmonary oedema and high-altitude cerebral oedema. Medical problems are caused by hypobaric hypoxia stimulating hypoxia-inducible factor (HIF) release. As a result, the central nervous system, circulation and respiratory system function impairment occurs. The most important factor in AMS treatment is acclimatization, withdrawing further ascent and rest or beginning to descent; oxygen supplementation, and pharmacological intervention, and, if available, a portable hyperbaric chamber...
2016: Przegla̧d Epidemiologiczny
https://www.readbyqxmd.com/read/27793615/seasonal-variation-of-metabolism-in-lizard-phrynocephalus-vlangalii-at-high-altitude
#19
Shiwei Liang, Weixin Li, Yang Zhang, Xiaolong Tang, Jianzheng He, Yucheng Bai, Dongqin Li, Yan Wang, Qiang Chen
Seasonal acclimatization is important for animals to live optimally in the varying environment. Phrynocephalus vlangalii, a species of lizard endemic in China, distributes on Qinghai-Tibet Plateau ranging from 2000 to 4600m above sea level. To dissect how this lizard mediate metabolism to adapt various season, the preferred body temperature (Tb), standard metabolic rate (SMR), mitochondrial respiration rates and activities of four metabolic enzymes in this species were tested in different seasons (spring, summer, and autumn)...
January 2017: Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology
https://www.readbyqxmd.com/read/27754698/effect-of-increased-blood-flow-on-pulmonary-circulation-before-and-during-high-altitude-acclimatization
#20
Matthias Peter Hilty, Andrea Müller, Daniela Flück, Christoph Siebenmann, Peter Rasmussen, Stefanie Keiser, Katja Auinger, Carsten Lundby, Marco Maggiorini
Matthias Peter Hilty, Andrea Mueller, Daniela Flück, Christoph Siebenmann, Peter Rasmussen, Stefanie Keiser, Katja Auinger, Carsten Lundby, and Marco Maggiorini. Effect of increased blood flow on the pulmonary circulation before and during high altitude acclimatization. High Alt Med Biol. 17:305-314, 2016.-Introduction and Methods: Acute exposure to high altitude increases pulmonary artery pressure (Ppa) and pulmonary vascular resistance (PVR). The evolution of Ppa and PVR with continuous hypoxic exposure remains, however, elusive...
December 2016: High Altitude Medicine & Biology
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