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Acne inversa

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https://www.readbyqxmd.com/read/29924129/radical-resection-and-local-coverage-of-hidradenitis-suppurativa-acne-inversa-analysis-of-results
#1
Rogério Rafael DA Silva Mendes, Rafael Ferreira Zatz, Miguel Luiz Antonio Modolin, Fábio DE Freitas Busnardo, Rolf Gemperli
OBJECTIVE: to evaluate the primary outcome of local complications and late recurrence in patients with hidradenitis suppurativa undergoing radical resection and specific reconstruction. METHODS: we conducted a retrospective analysis of the medical records of patients attended by the Plastic Surgery Service of the Clinics Hospital, Medical School, USP, between 2010 and 2016. We included patients who underwent radical resection of hidradenitis suppurativa in advanced stage and reconstruction through primary closure, grafts or flaps...
2018: Revista do Colégio Brasileiro de Cirurgiões
https://www.readbyqxmd.com/read/29860040/long-term-adalimumab-efficacy-in-patients-with-moderate-to-severe-hidradenitis-suppurativa-acne-inversa-3-year-results-of-a-phase-3-open-label-extension-study
#2
Christos C Zouboulis, Martin M Okun, Errol P Prens, Robert Gniadecki, Peter A Foley, Charles Lynde, Jamie Weisman, Yihua Gu, David A Williams, Gregor B E Jemec
BACKGROUND: The long-term optimal dosing strategy for adalimumab in hidradenitis suppurativa/acne inversa (HS) was evaluated by pooling the results of the PIONEER phase 3 trials and an open-label extension (OLE) study. OBJECTIVE: To assess response and tolerability of long-term adalimumab in HS. METHODS: The durations of PIONEER I/II periods A, B, and OLE were 12, 24, and ≥ 52 weeks, respectively. Patients who entered the OLE and received adalimumab 40 mg every week continuously (ADAew) and responders plus partial responders (PRR) were evaluated...
May 31, 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29709603/photodynamic-therapy-for-hidradenitis-suppurativa-acne-inversa-case-report
#3
Yunjie Zhang, Yuguang Yang, Xianbiao Zou
Hidradenitis suppurativa/acne inversa (HS/AI) is a type of chronic suppurative inflammatory reaction of the hair follicles characterized by recurrent dermal abscesses, sinus tracts and scars. So far, there has not been any prospective study proving the efficacy and safety of photodynamic therapy for the disease. In this report, one case of HS/AI achieved resolution of skin lesions, ulcer healing and disappearance of symptoms after nine treatments with 5-aminolevulinic acid photodynamic therapy (ALA-PDT).
June 2018: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29683279/hidradenitis-suppurativa-acne-inversa-a-prospective-bacteriological-study-of-46-patients-and-review-of-the-literature
#4
Valentina Benzecry, Anna Grancini, Elena Guanziroli, Gianluca Nazzaro, Mauro Barbareschi, Angelo V Marzano, Simona Muratori, Stefano Veraldi
BACKGROUND: Hidradenitis suppurativa is a chronic inflammatory disease of the hair follicle that usually involves specific anatomic areas which are partially occluded, have a higher density of eccrine and apocrine sweat glands and a higher pH. These characteristics could promote the superinfection of certain group of bacteria. We aimed to describe the bacteria that can be isolated from hidradenitis lesions and to establish a correlation between bacteriological results and clinical data...
April 19, 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29645385/s1-leitlinie-dermatosen-bei-dermaler-lymphostase
#5
Joachim Dissemond, Finja Jockenhöfer, Anya Miller, Günter Kurzhals, Shahrouz Noori, Stefanie Reich-Schupke, Martin Schlaeger, Erich Schubert, Markus Stücker, Tobias Weberschock, Hans Wilfried Jungkunz
Das Ziel dieser S1-Leitlinie ist es, aktuelles Wissen über dermatologisch relevante Krankheitsbilder bei lokal begrenzter dermaler Lymphostase an allen Lokalisationen des Hautorgans zu vermitteln, um diese frühzeitig zu erkennen, diagnostisch zu sichern und gezielt zu behandeln. Wann immer möglich, sollte diese Therapie anhand klar definierter Algorithmen stadiengerecht erfolgen. Die im klinischen Alltag häufig auftauchenden differenzialdiagnostischen und therapeutischen Fragen lassen eine aktuelle Leitlinie notwendig erscheinen...
April 2018: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/29573406/th17-treg-imbalance-in-hidradentitis-suppurativa-acne-inversa-the-link-to-hair-follicle-dissection-obesity-smoking-and-autoimmune-comorbidities
#6
REVIEW
B C Melnik, S M John, W Chen, G Plewig
BACKGROUND: Disintegration of the infundibula of terminal hair follicles (HF) in intertriginous skin areas exhibits the histological hallmark of hidradenitis suppurativa (HS)/acne inversa, featuring a dissecting terminal hair folliculitis. Elevated serum levels of interleukin 17 and local increase in the ratio of proinflammatory Th17 cells and antiinflammatory regulatory T cells (Tregs) have been reported. Perifollicular Tregs play a key role for HF stem cell homeostasis and infundibular integrity...
March 24, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29569780/a-new-nonsense-mutation-in-the-poglut1-gene-in-two-sisters-with-dowling-degos-disease
#7
S Duchatelet, H Clerc, L Machet, P Gaboriaud, S Miskinyte, T Kervarrec, A Hovnanian
Dowling-Degos disease (DD) (OMIM: 179850, 615327, 615674, 615696) is a rare autosomal-dominant genetic disorder belonging to the spectrum of reticulated pigmented dermatitis(1). Galli-Galli disease is considered as being a variant of DD, harboring all clinical, histological and genetics features of DD in association with acantholysis (2). In 2006, exome sequencing revealed loss-of-function mutations in KRT5 (cytokeratin 5) (p.Ile140fsAsnfs*39, p.Ser5*) in 8 of 10 DD cases (3). Since then, mutations in POGLUT1, encoding O-glucosylosyltransferase 1 enzyme, were reported in Galli-Galli cases (4)...
March 23, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29497777/-correction-to-drug-therapy-of-acne-inversa
#8
S Schneider-Burrus, E Arpa, C Kors, T Stavermann, R Sabat, G Kokolakis
No abstract text is available yet for this article.
March 2018: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/29322225/-surgical-treatment-options-for-hidradenitis-suppurativa-acne-inversa
#9
REVIEW
L Scholl, S Hessam, S Reitenbach, F G Bechara
Hidradenitis suppurativa/acne inversa (HS/AI) is a chronic inflammatory skin disease. Therapy consists of conservative and surgical treatment options. In Hurley stages II and III, surgical intervention is regarded as the method of choice for areas with irreversible tissue destruction. Resection techniques with different grades of invasiveness are described in the literature. Nevertheless, there is no generally accepted concept regarding resection and reconstruction techniques or specific postoperative care...
February 2018: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/29234829/-drug-therapy-of-acne-inversa
#10
REVIEW
S Schneider-Burrus, E Arpa, C Kors, T Stavermann, R Sabat, G Kokolakis
Acne inversa is a chronic inflammatory destructive skin disease that affects about 1% of the population. The therapy should be personalized and consists of surgical and conservative procedures. Antibiotics are administered either topically or systemically. Combination therapy with clindamycin and rifampicin for 10-12 weeks can be very effective. Furthermore, TNF-α inhibitors show adequate efficacy and can be recommended. Adalimumab is the only approved drug product for systemic treatment of acne inversa...
January 2018: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/29159469/-acne-inversa-hidradenitis-suppurativa-an-update
#11
REVIEW
R Sabat, A Tsaousi, J Rossbacher, H Kurzen, T Fadai, U Schwichtenberg, S Schneider-Burrus, G Kokolakis, K Wolk
Acne inversa (AI)/hidradenitis suppurativa is a chronic, recurrent, immune-mediated dermatosis characterized by deep inflammatory nodules, abscesses, fistulas, and undermined scars in skin areas bearing apocrine glands. In addition to the cutaneous manifestation, numerous AI patients show metabolic changes, spondyloarthritis, and depression. AI leads to a strong reduction in the quality of life and an impairment of the sexual life of affected individuals and often culminates in social withdrawal, stigmatization, unemployment, and suicidal thoughts...
December 2017: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/29110042/-acne-inversa-hidradenitis-suppurativa-a-challenge-for-the-future
#12
REVIEW
R Sabat
Acne inversa (AI)/hidradenitis suppurativa is a chronic recurrent inflammatory dermatosis with signs of a systemic disease. AI is characterized by typical skin alterations in body areas bearing apocrine glands. The care of the AI patients in Germany is still inadequate. This situation might be significantly improved through the following efforts: (i) shortening of the time between the disease onset and the diagnosis/start of therapy; (ii) the in-depth investigation of AI pathogenesis with the aim of identifying innovative therapeutic targets and blood biomarkers; (iii) establishing a method for quantifying the severity of the disease, which takes into account both the clinical assessment and objective laboratory parameters and the self-assessment of the patient (e...
December 2017: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/28683447/swiss-practice-recommendations-for-the-management-of-hidradenitis-suppurativa-acne-inversa
#13
Robert E Hunger, Emanuel Laffitte, Severin Läuchli, Carlo Mainetti, Michael Mühlstädt, Peter Schiller, Anne-Karine Lapointe, Pascale Meschberger, Alexander A Navarini
Hidradenitis suppurativa (HS) is a painful, inflammatory, debilitating skin disease with a chronic intermittent course. The central pathogenetic event seems to be the occlusion of the hair follicle. HS has a 1-year prevalence of about 1%. It typically presents after puberty with painful, deep-seated, inflamed lesions in the apocrine gland-bearing areas of the body: most commonly the axillae, inguinal, and anogenital regions. HS has a high negative impact on patients' quality of life even in patients with only limited disease burden, and the diagnosis of HS is often made with a long diagnostic delay...
2017: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/28636793/development-and-validation-of-the-international-hidradenitis-suppurativa-severity-score-system-ihs4-a-novel-dynamic-scoring-system-to-assess-hs-severity
#14
C C Zouboulis, T Tzellos, A Kyrgidis, G B E Jemec, F G Bechara, E J Giamarellos-Bourboulis, J R Ingram, T Kanni, I Karagiannidis, A Martorell, Ł Matusiak, A Pinter, E P Prens, D Presser, S Schneider-Burrus, E von Stebut, J C Szepietowski, H H van der Zee, S M Wilden, R Sabat
BACKGROUND: A validated tool for the dynamic severity assessment of hidradenitis suppurativa/acne inversa (HS) is lacking. OBJECTIVES: To develop and validate a novel dynamic scoring system to assess the severity of HS. METHODS: A Delphi voting procedure was conducted among the members of the European Hidradenitis Suppurativa Foundation (EHSF) to achieve consensus towards an initial HS Severity Score System (HS4). Strengths and weaknesses of HS4 were examined by a multicentre prospective study...
November 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28601418/psenen-mutation-carriers-with-co-manifestation-of-acne-inversa-ai-and%C3%A2-dowling-degos-disease-ddd-is%C3%A2-ai%C3%A2-or%C3%A2-ddd-the-subphenotype
#15
Chengrang Li, Wenrui Li, Haoxiang Xu, Xiaofeng Zhang, Bin Su, Wanlu Zhang, Xue Zhang, Baoxi Wang
No abstract text is available yet for this article.
October 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28321845/hidradenitis-suppurativa-gains-increasing-interest-on-world-wide-web-a-source-for-patient-information
#16
Schapoor Hessam, Johannes Salem, Falk G Bechara, Axel Haferkamp, Axel Heidenreich, Pia Paffenholz, Michael Sand, Igor Tsaur, Hendrik Borgmann
BACKGROUND: Gathering health information from Internet websites is increasingly utilized by patients. No data exist about hidradenitis suppurativa (HS)-related online health information. Thus, we aimed to study the quality, popularity, readability, and timeliness of the most frequented websites on HS. METHODS: Google Trends was used to evaluate the public interest in HS. An Internet search on Google was performed for the terms "hidradenitis suppurativa," "acne inversa," and "Verneuil's disease...
July 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28287404/mutations-in-%C3%AE-secretase-subunit-encoding-psenen-underlie-dowling-degos-disease-associated-with-acne-inversa
#17
Damian J Ralser, F Buket Ü Basmanav, Aylar Tafazzoli, Jade Wititsuwannakul, Sarah Delker, Sumita Danda, Holger Thiele, Sabrina Wolf, Michélle Busch, Susanne A Pulimood, Janine Altmüller, Peter Nürnberg, Didier Lacombe, Uwe Hillen, Jörg Wenzel, Jorge Frank, Benjamin Odermatt, Regina C Betz
Dowling-Degos disease (DDD) is an autosomal-dominant disorder of skin pigmentation associated with mutations in keratin 5 (KRT5), protein O-fucosyltransferase 1 (POFUT1), or protein O-glucosyltransferase 1 (POGLUT1). Here, we have identified 6 heterozygous truncating mutations in PSENEN, encoding presenilin enhancer protein 2, in 6 unrelated patients and families with DDD in whom mutations in KRT5, POFUT1, and POGLUT1 have been excluded. Further examination revealed that the histopathologic feature of follicular hyperkeratosis distinguished these 6 patients from previously studied individuals with DDD...
April 3, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28256718/lipocalin-2-is-expressed-by-activated-granulocytes-and-keratinocytes-in-affected-skin-and-reflects-disease-activity-in-acne-inversa-hidradenitis-suppurativa
#18
K Wolk, J Wenzel, A Tsaousi, E Witte-Händel, N Babel, C Zelenak, H-D Volk, W Sterry, S Schneider-Burrus, R Sabat
BACKGROUND: Acne inversa (AI)/hidradenitis suppurativa is a chronic inflammatory disease characterized by painful axillary, inguinal and perianal skin lesions with deep-seated nodules, abscesses and fistulae. OBJECTIVES: This study aimed to identify and characterize the key players in AI pathogenesis. METHODS: Epidemiological and anamnestic data for patients with AI were collected, and blood and skin samples were also taken. Healthy participants and patients with psoriasis served as controls...
November 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/27976439/prospective-multicentre-cohort-study-on-9154-surgical-procedures-to-assess-the-risk-of-postoperative-bleeding-a-dessi-study
#19
MULTICENTER STUDY
W Koenen, C Kunte, D Hartmann, H Breuninger, M Moehrle, F G Bechara, H J Schulze, A Lösler, C R Löser, T Wetzig, D Pappai, S Rapprich, C Weiß, J Faulhaber
BACKGROUND: To date, there is still a debate how to deal with patients receiving antithrombotic agents prior to surgical procedures on the skin. OBJECTIVE: To prospectively assess complications after dermatosurgical interventions, especially bleeding, depending on anticoagulation therapy. METHODS: Patients underwent surgery consecutively as scheduled, without randomization, whether or not they were currently taking anticoagulants. Nine institutions of the DESSI (DErmatoSurgical Study Initiative) working group documented patient data prospectively on a standardized study sheet prior to and after 9154 dermatosurgical interventions...
April 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27900998/novel-mutations-in-psenen-gene-in-two-chinese-acne-inversa-families-manifested-as-familial-multiple-comedones-and-dowling-degos-disease
#20
Cheng Zhou, Guang-Dong Wen, Lwin Myint Soe, Hong-Jun Xu, Juan Du, Jian-Zhong Zhang
BACKGROUND: Acne inversa (AI), also called hidradenitis suppurativa, is a chronic, inflammatory, recurrent skin disease of the hair follicle. Familial AI shows autosomal-dominant inheritance caused by mutations in the γ-secretase genes. This study was aimed to identify the specific mutations in the γ-secretase genes in two Chinese families with AI. METHODS: In this study, two Chinese families with AI were investigated. All the affected individuals in the two families mainly manifested with multiple comedones, pitted scars, and a few inflammatory nodules on their face, neck, trunk, axilla, buttocks, upper arms, and thighs...
December 5, 2016: Chinese Medical Journal
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