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Acne inversa

Alice Gottlieb, Alan Menter, April Armstrong, Christopher Ocampo, Yihua Gu, Henrique D Teixeira
BACKGROUND: Hidradenitis Suppurativa (HS), also known as acne inversa, is a painful, chronic, debilitating, inflammatory skin disease and has shown response to anti-TNF-α therapy. Efficacy and safety of the anti-TNF-α agent, adalimumab, was assessed in a post hoc analysis of women from the first 16 weeks of a phase 2 study of men and women with HS. METHODS: Patients with moderate-to-severe HS in at least 2 body areas, unresponsive or intolerant to oral antibiotics for treatment of their HS, and with no previous anti-TNF-a or systemic non-biologic treatment, were randomized 1:1:1 to 40 mg adalimumab-weekly or every-other-week, or placebo...
October 1, 2016: Journal of Drugs in Dermatology: JDD
WenChieh Chen, Gerd Plewig
Hidradenitis suppurativa/acne inversa is a diverse, enigmatic and distressful disease that has aroused growing interest in specialists from different disciplines. Both names describe its classical manifestations in the intertriginous regions and reflect the historical view of the disease definition, but cause confusions in the understanding of its pathogenesis and classification. In light of the advance in clinical, histopathological and pathophysiological findings, we propose the term "dissecting terminal hair folliculitis" (DTHF) to characterize its disease nature as folliculitis instead of acneiform disease or apocrine gland disorder...
September 13, 2016: Experimental Dermatology
Christos C Zouboulis
INTRODUCTION: Hidradenitis suppurativa/acne inversa (HS) is a chronic, inflammatory, recurrent, debilitating skin disease of the hair follicle that usually presents after puberty with painful, deep-seated, inflamed lesions in the apocrine gland-bearing areas of the body, most commonly the axillae, inguinal and anogenital regions. A mean disease incidence of 6.0 per 100,000 persons-years and a varying prevalence of 0.05-1% have been reported worldwide. AREAS COVERED: This manuscript summarizes the current evidence on chemistry, pharmacodynamics, pharmacokinetics, as well as clinical efficacy, safety and tolerability of the currently approved biologic drug adalimumab in the treatment of active moderate to severe HS in adults...
October 2016: Expert Review of Clinical Immunology
Uwe Wollina, Dana Langner, Birgit Heinig, Andreas Nowak
BACKGROUND: Acne inversa (hidradentitis suppurativa; AI) is a severe chronic relapsing inflammatory skin disease of unknown cause. Anogenital AI has the strongest negative impact on quality of life and causes great disability. OBJECTIVES: We analyzed patients, comorbities, outcome of extensive surgery, and possible adverse effects. PATIENTS AND METHODS: We included patients from January 2000 to March 2015 with anogenital AI Hurley grade III...
August 6, 2016: International Journal of Dermatology
S Tugnoli, V Bettoli, C Agnoli, S Caracciolo
Hidradenitis Suppurative-Acne Inversa is one of the most debilitating chronic skin diseases. It seriously affects the emotional and relational life of the patient, it has a significant psychiatric comorbidity and it impairs the quality of life. We present the report of a clinical situation with onset of the illness in a young woman during pregnancy, a case characterized by particular evolution, severe systemic involvement, strong psycho-emotional impact on the patient and impairment of subjective well-being of the caregiver...
May 2016: La Clinica Terapeutica
Ioannis Karagiannidis, Georgios Nikolakis, Robert Sabat, Christos C Zouboulis
Hidradenitis suppurativa / acne inversa (HS) is a chronic inflammatory, debilitating skin disorder with a largely unknown etiology. However, many observations such as the typical onset of the disease after puberty, the female predominance, the pre-menstrual flare ups and the improvement during pregnancy suggest a contribution of endocrinological factors to the emergence of the disease. In addition, the reported efficacy of anti-androgen treatment on HS indicates a possible involvement of androgens in the pathogenesis...
June 13, 2016: Reviews in Endocrine & Metabolic Disorders
Vincenzo Bettoli, Giulia Toni, Michela Ricci, Stefania Zauli, Annarosa Virgili
No abstract text is available yet for this article.
June 2016: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
Evangelos J Giamarellos-Bourboulis, Matthias Platzer, Ioannis Karagiannidis, Theodora Kanni, Georgios Nikolakis, Jens Ulrich, Michael Bellutti, Harald Gollnick, Michael Bauer, Christos C Zouboulis, Klaus Huse
Hidradenitis suppurativa/acne inversa (HS) has a multifactorial pathogenesis, with many patients reporting positive family history. Nine β-defensin genes (among them DEFB4 and DEFB103, encoding for proinflammatory mediators human β-defensin-2 and human β-defensin-3, respectively) exist as a cluster (DEFB) affected by copy number (CN). We hypothesized that CNs are greater in patients with HS and that they are linked to genetic susceptibility. CNs of DEFB were studied in two independent patient cohorts: 163 patients from Greece and 98 from Germany...
August 2016: Journal of Investigative Dermatology
Yuan Liu, Ting Miao, Jingyue Ma, Lili Shao, Suju Luo, Yan Li, Quanzhong Liu
No abstract text is available yet for this article.
June 1, 2016: European Journal of Dermatology: EJD
Vincenzo Bettoli, Stefania Zauli, Anna Virgili
No abstract text is available yet for this article.
April 2016: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
J W Frew
No abstract text is available yet for this article.
March 2016: British Journal of Dermatology
Wayne Gulliver, Christos C Zouboulis, Errol Prens, Gregor B E Jemec, Thrasivoulos Tzellos
Hidradenitis suppurativa/acne inversa (HS) is a chronic inflammatory skin disease characterized by painful, recurrent nodules and abscesses that rupture and lead to sinus tracts and scarring. To date, an evidence-based therapeutic approach has not been the standard of care and this is likely due to the lack of evidence based treatment guidelines. The purpose of this study was to promote a holistic evidence-based approach which implemented Level of Evidence and Strength of Recommendation for the treatment of HS...
February 1, 2016: Reviews in Endocrine & Metabolic Disorders
Alexander Meyer, Raymund E Horch, Elisabeth Schoengart, Justus P Beier, Christian D Taeger, Andreas Arkudas, Werner Lang
PURPOSE: Free flap transplantation to vascular reconstructions as arteriovenous (AV) loops has been established in centers as a feasible therapeutic option for defect reconstruction in the absence of proper recipient vessels, caused by oncologic resections, radiation, or trauma. We report our 10-year experience in free flap transplantation after vascular reconstruction with special emphasis on complication rate and postoperative mobility. PATIENTS AND METHODS: Forty-seven patients (mean age: 60 years, range: 19-86) were included...
April 2016: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
Raphael Parrado, Manuel Cadena, Arturo Vergara, Diana Cadena, Juan G Chalela
Hidradenitis suppurativa (HS), also known as acne inversa, is a chronic, recurrent inflammatory disease affecting skin that bears apocrine glands. It is characterised by the presence of tender subcutaneous nodules that may rupture, resulting in deep dermal abscesses, fibrosis with dermal contractures and induration of the skin. The management of HS is a challenge for physicians as the pathogenesis is not clearly defined and prevents the use and development of directed therapies. Treatment options are oral agents (antibiotics, immunomodulators) and surgical excision...
December 13, 2015: International Wound Journal
Carina M Woodruff, Abbas M Charlie, Kieron S Leslie
Hidradenitis suppurativa is a chronic inflammatory disease of apocrine gland-bearing skin. Although immunologic derangements, genetic predisposition, obesity, and smoking are likely important factors, the pathogenesis of the disease and the effect of available treatments on disease course have not been fully elucidated. In the absence of proper treatment, chronic inflammation results in diffuse scarring and a wide array of complications, including the development of cutaneous squamous cell carcinoma. This severe and chronic disease can have detrimental effects on self-esteem and quality of life...
December 2015: Mayo Clinic Proceedings
Andrea Chiricozzi, Sara Faleri, Chiara Franceschini, Raffaele Dante Caposiena Caro, Sergio Chimenti, Luca Bianchi
INTRODUCTION: Hidradenitis suppurativa (HS) is a chronic, disabling, skin disorder. Because of renewed scientific interest in HS, different aspects of the condition, such as disease severity assessment, are being investigated and better defined. The aim of this study is to provide a novel tool for the assessment of disease severity. METHODS AND MATERIALS: An HS-tailored, composite, dynamic score, named the Acne Inversa Severity Index (AISI) was designed to include a physician-rated assessment that considers the type of lesions occurring and the affected body sites...
October 2015: Wounds: a Compendium of Clinical Research and Practice
X Xiao, Y He, C Li, X Zhang, H Xu, B Wang
BACKGROUND: Acne inversa (AI) is a chronic inflammatory skin disease with an autosomal dominant inheritance pattern. Mutations of the gene encoding nicastrin (NCSTN), a cofactor subunit of γ-secretase, are responsible for familial AI. However, whether deficiency of nicastrin is functionally implicated in the biological behaviours of human keratinocytes and related molecular mechanisms remains unknown. OBJECTIVES: To study alterations of biological traits and related signalling pathways modulated by nicastrin knockdown in keratinocytes...
March 2016: British Journal of Dermatology
Errol Prens, Inge Deckers
The pathogenesis of hidradenitis suppurativa (HS) or acne inversa is not completely understood. Recent research has led to greater insight into the mechanisms involved in the disease. The primary defect in HS pathophysiology rests with the hair follicle. Follicular occlusion, followed by follicular rupture, and a foreign body-type immune response are necessary conditions for the development of clinical HS. A specific genetic signature and environmental factors, such as cigarette smoking, microbial colonization, and adiposity, all contribute to the HS phenotype...
November 2015: Journal of the American Academy of Dermatology
F William Danby, Paul G Hazen, Jurr Boer
When the prevention of new lesions fails and when medical therapy of established and growing lesions is ineffective, surgery is the accepted method of dealing with hidradenitis suppurativa/acne inversa. The rationale and preferred techniques of mini-unroofing using a biopsy punch, deroofing using scissors, electrosurgery or laser, and classical wide excision and closure are discussed. The situation in which incision and drainage is considered for temporary pain relief would be best considered an opportunity for deroofing, as illustrated in the accompanying online videos...
November 2015: Journal of the American Academy of Dermatology
F William Danby
Full control of hidradenitis suppurativa requires the prevention of new lesions. These appear to be induced by a complex series of hormonally driven molecular activities that lead to obstruction of the follicular duct, rupture and destruction of the sebaceous glands, the development of deep dermal sinuses that subsequently rupture to the surface, and production of an invasive subcutaneous mass that is resistant to medical therapy. Preliminary observations suggest that the use of a healthy and fully natural zero dairy and low glycemic-load diet may provide relief from progression of the lesions and possibly prevention of new lesions, even when medications fail...
November 2015: Journal of the American Academy of Dermatology
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