Shahin Tavakol, Valeria Kebets, Jessica Royer, Qiongling Li, Hans Auer, Jordan DeKraker, Elizabeth Jefferies, Neda Bernasconi, Andrea Bernasconi, Christoph Helmstaedter, Thaera Arafat, Jorge Armony, R Nathan Spreng, Lorenzo Caciagli, Birgit Frauscher, Jonathan Smallwood, Boris Bernhardt
OBJECTIVE: Temporal lobe epilepsy (TLE) is typically associated with pathology of the hippocampus, a key structure involved in relational memory, including episodic, semantic, and spatial memory processes. While it is widely accepted that TLE-associated hippocampal alterations underlie memory deficits, it remains unclear whether impairments relate to a specific cognitive domain or multiple ones. METHODS: We administered a recently validated task paradigm to evaluate episodic, semantic, and spatial memory in 24 pharmacoresistant TLE patients and 50 age- and sex-matched healthy controls...
April 20, 2024: Epilepsy & Behavior: E&B