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https://www.readbyqxmd.com/read/27824224/isolated-interdigital-kaposi-sarcom-in-hiv-negative-patient
#1
Amil G Bahali, Ozlem Su, Dilek Biyikozkaya, Didem Dizman, Zeynep Tosuner, Cuyan Demirkesen, Nahide Onsun
No abstract text is available yet for this article.
December 2016: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/27795414/identification-of-novel-kshv-orf50-transcripts-discovery-of-new-rta-isoforms-with-variable-transactivation-potential
#2
Brian S Wakeman, Yoshihiro Izumiya, Samuel H Speck
: Kaposi's sarcoma-associated herpesvirus (KSHV) is a gammaherpesvirus that has been associated with primary effusion lymphoma, multicentric Castleman's disease, as well as its namesake Kaposi's sarcoma. As a gammaherpesvirus, KSHV is able to acutely replicate, enter latency, and reactivate from this latent state. A key protein involved in both acute replication and reactivation from latency is the replication and transcriptional activator (RTA) encoded by the gene Orf50. RTA is a known transactivator of multiple viral genes allowing for it to control the switch between latency and virus replication...
October 19, 2016: Journal of Virology
https://www.readbyqxmd.com/read/27754006/js-ish-esh-2-update-on-the-detection-and-follow-up-of-early-hypertensive-heart-disease
#3
Enrico Agabiti Rosei
Current Hypertension Guidelines emphasize the importance of assessing the presence of preclinical organ damage. In fact, an extensive evaluation of organ damage may increase the number of patients classified at high CV risk and therefore strongly influence the clinical management of patients. Hypertensive heart disease remains to date the form of organ damage for which there is the greatest amount of evidence of a strong independent prognostic significance. In the presence of a chronic pressure overload, a parallel addition of sarcomers takes place with an increase in myocyte width, which in turn increases left ventricular wall thickness; myocyte hypertrophy is also associated with apoptosis, collagen deposition and ventricular fibrosis with an impairment of coronary hemodynamics as well, thus profoundly influencing functional properties of the left (and right) ventricle...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27642917/js-ish-esh-2-update-on-the-detection-and-follow-up-of-early-hypertensive-heart-disease
#4
Enrico Agabiti Rosei
Current Hypertension Guidelines emphasize the importance of assessing the presence of preclinical organ damage. In fact, an extensive evaluation of organ damage may increase the number of patients classified at high CV risk and therefore strongly influence the clinical management of patients. Hypertensive heart disease remains to date the form of organ damage for which there is the greatest amount of evidence of a strong independent prognostic significance. In the presence of a chronic pressure overload, a parallel addition of sarcomers takes place with an increase in myocyte width, which in turn increases left ventricular wall thickness; myocyte hypertrophy is also associated with apoptosis, collagen deposition and ventricular fibrosis with an impairment of coronary hemodynamics as well, thus profoundly influencing functional properties of the left (and right) ventricle...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/26928838/effectiveness-of-oral-cholera-vaccine-in-haiti-37-month-follow-up
#5
Karine Sévère, Vanessa Rouzier, Stravinsky Benedict Anglade, Claudin Bertil, Patrice Joseph, Alexandra Deroncelay, Marie Marcelle Mabou, Peter F Wright, Florence Duperval Guillaume, Jean William Pape
The first oral cholera vaccine (OCV) campaign, since its prequalification by the World Health Organization, in response to an ongoing cholera epidemic (reactive vaccination) was successfully conducted in a poor urban slum of approximately 70,000 inhabitants in Port-au-Prince, Haiti, in 2012. Vaccine coverage was 75% of the target population. This report documents the impact of OCV in reducing the number of culture-confirmed cases of cholera admitted to the Groupe Haïtien d'Etude du Sarcome de Kaposi et des Infections Opportunistes (GHESKIO) cholera treatment center from that community in the 37 months postvaccination (April 2012-April 30, 2015)...
May 4, 2016: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/26541413/off-label-use-of-targeted-therapies-in-osteosarcomas-data-from-the-french-registry-outc-s-observatoire-de-l-utilisation-des-th%C3%A3-rapies-cibl%C3%A3-es-dans-les-sarcomes
#6
Mathilde Penel-Page, Isabelle Ray-Coquard, Julie Larcade, Magali Girodet, Laure Bouclier, Muriel Rogasik, Nadège Corradini, Natacha Entz-Werle, Laurence Brugieres, Julien Domont, Cyril Lervat, Sophie Piperno-Neumann, Helène Pacquement, Jacques-Olivier Bay, Jean-Claude Gentet, Antoine Thyss, Loic Chaigneau, Bérangère Narciso, Helène Cornille, Jean-Yves Blay, Perrine Marec-Bérard
BACKGROUND: The objective of this study is to explore the off-label use of targeted therapies (TTs) for patients with osteosarcoma registered within the French Sarcoma Group--Bone Tumor Study Group (GSF-GETO) national registry. METHODS: All patients with an osteosarcoma, registered between January 1, 2009 and July 15, 2013 were analyzed. RESULTS: Twenty-nine patients with refractory relapsed osteosarcomas received 33 treatment lines of TTs...
2015: BMC Cancer
https://www.readbyqxmd.com/read/25705270/retrospective-study-on-osteosarcoma-and-ewing-sarcoma-our-experience
#7
Daniela Nedelcu, Nicoleta Andreescu, Estera Boeriu, Radu Stefanescu, Smaranda Arghirescu, Maria Puiu
INTRODUCTION: Primary bone tumors are relatively rare types of cancer. Their relative frequency is not yet well established and still there is more information needed regarding the evolution and prognosis of those patients. OBJECTIVES: We analyzed several factors (site of lesion, tumor stage, tumor volume, disease related complications, therapy related complications) that influenced the evolution of bone tumor in a lot of patients diagnosed with osteosarcoma or Ewing sarcome...
June 2014: Mædica
https://www.readbyqxmd.com/read/25377264/fetal-heart-extract-facilitates-the-differentiation-of-human-umbilical-cord-blood-derived-mesenchymal-stem-cells-into-heart-muscle-precursor-cells
#8
Truc Le-Buu Pham, Tam Thanh Nguyen, Anh Van Bui, My Thu Nguyen, Phuc Van Pham
Human umbilical cord blood-derived mesenchymal stem cells (UCB-MSCs) are a promising stem cell source with the potential to modulate the immune system as well as the capacity to differentiate into osteoblasts, chondrocytes, and adipocytes. In previous publications, UCB-MSCs have been successfully differentiated into cardiomyocytes. This study aimed to improve the efficacy of differentiation of UCB-MSCs into cardiomyocytes by combining 5-azacytidine (Aza) with mouse fetal heart extract (HE) in the induction medium...
August 2016: Cytotechnology
https://www.readbyqxmd.com/read/25300878/effect-on-survival-of-local-ablative-treatment-of-metastases-from-sarcomas-a-study-of-the-french-sarcoma-group
#9
MULTICENTER STUDY
A T Falk, L Moureau-Zabotto, M Ouali, N Penel, A Italiano, J-O Bay, T Olivier, M-P Sunyach, P Boudou-Roquette, S Salas, C Le Maignan, A Ducassou, N Isambert, E Kalbacher, C Pan, E Saada, F Bertucci, A Thyss, J Thariat
AIMS: Recent data suggest that patients with pulmonary metastases from sarcomas might benefit from ablation of their metastases. Some data are available regarding osteosarcomas/angiosarcomas and lung metastases. The purpose of this study was to assess the efficacy of local ablative treatment on the survival of patients with oligometastases (one to five lesions, any metastatic site, any grade/histology) from sarcomas. MATERIALS AND METHODS: A multicentric retrospective study of the French Sarcoma Group was conducted in sarcoma patients with oligometastases who were treated between 2000 and 2012...
January 2015: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/25071001/treatment-outcomes-for-patients-with-multidrug-resistant-tuberculosis-in-post-earthquake-port-au-prince-haiti
#10
Macarthur Charles, Stalz Charles Vilbrun, Serena P Koenig, Lauren M Hashiguchi, Marie Marcelle Mabou, Oksana Ocheretina, Jean W Pape
We report outcomes and 12-month survival for the first cohort of patients to undergo multidrug-resistant tuberculosis (MDR-TB) treatment after the earthquake in Haiti. From March 3, 2010 to March 28, 2013, 110 patients initiated treatment of laboratory-confirmed MDR-TB at the Groupe Haïtien d'Etude du Sarcome de Kaposi et des Infections Opportunistes (GHESKIO) Center in Port-au-Prince, Haiti. Twenty-seven patients (25%) were human immunodeficiency virus (HIV)-positive. As of October 31, 2013, 95 (86%) patients were either cured or alive on treatment, 4 (4%) patients defaulted, and 11 (10%) patients died...
October 2014: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/24905939/intracellular-mmp-2-activity-in-skeletal-muscle-is-associated-with-type-ii-fibers
#11
Elin Hadler-Olsen, Ann Iren Solli, Anne Hafstad, Jan-Olof Winberg, Lars Uhlin-Hansen
Matrix metalloproteinase 2 (MMP-2) is a proteolytic enzyme implicated in motility, differentiation, and regeneration of skeletal muscle fibers through processing of extracellular substrates. Although MMP-2 has been found to be localized intracellularly in cardiomyocytes where the enzyme is thought to contribute to post-ischemic loss of contractility, little is known about intracellular MMP-2 activity in skeletal muscle fibers. In the present study we demonstrate intracellular MMP-2 in normal skeletal muscle by immunohistochemical staining...
January 2015: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/24428059/-the-comparative-analysis-of-cardiac-contractility-associated-with-certain-causes-of-death
#12
REVIEW
A G Reznik
Results of the comparative analysis of structural changes in cardiomyocyte sarcomers revealed by polarization microscopy in certain fatal cases. The main causes of impaired cardiac contractility and cardiac arrest in the victims of craniocerebral injury and in the subjects with acute forms of ischemic heart disease (acute coronary artery insufficiency and acute myocardial infarction in the pre-necrotic phase), pneumonia, or mechanical strangulation asphyxia (resulting from hanging, with the loop placed around the anterior upper third of the neck and the knot in the posterolateral aspect)...
July 2013: Sudebno-meditsinskaia Ekspertiza
https://www.readbyqxmd.com/read/24321987/the-haiti-research-based-model-of-international-public-health-collaboration-the-gheskio-centers
#13
Jean W Pape, Patrice D Severe, Daniel W Fitzgerald, Marie M Deschamps, Patrice Joseph, Cynthia Riviere, Vanessa Rouzier, Warren D Johnson
For 3 decades, GHESKIO (the Groupe Haitien d'Etude du Sarcome de Kaposi et des Infections Opportunistes), the Haitian Ministry of Health, and Weill Cornell have pursued a tripartite mission of service, training, and translational research. The initial focus was on AIDS and tuberculosis. The mission has expanded to include the local community and now provides maternal-child health, family planning, cancer prevention and treatment, immunizations (including human papillomavirus, cholera), and primary education through vocational and microcredit programs...
January 1, 2014: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/23924754/is-mutation-p-arg168gly-in-tpm3-gene-responsible-for-type-1-fiber-hypoplasia-and-cap-structure-formation
#14
Anna Fidzianska, Agnieszka Madej-Pilarczyk, Irena Hausmanowa-Petrusewicz
Congenital fiber type disproportion with delayed fiber type maturation and the appearance of cap structures were analyzed in a child with p.Arg168Gly mutation in TPM3 gene. Very narrow myotube-like Type 1 fibers with single nuclei decorated by cap structures seem to be a result of a failure in fusion process and mature fiber formation. Repeated mutations in exon 5 of TPM3 gene giving cap structures may be a different consequence of the loss of specific isoform normally operating in the fusion process and sarcomer formation...
January 2014: Clinical Neuropathology
https://www.readbyqxmd.com/read/23153096/an-english-translation-of-joseph-luc-riopelle-md-h%C3%A3-tel-dieu-of-montr%C3%A3-al-and-jean-paul-th%C3%A3-riault-h%C3%A3-pital-g%C3%A3-n%C3%A3-ral-of-verdun-qu%C3%A3-bec-canada-sur-une-forme-m%C3%A3-connue-de-sarcome-des-parties-molles-le-rhabdomyosarcome-alv%C3%A3-olaire-concerning-an-unrecognized-form
#15
R Beverly Raney, Odile Oberlin, David M Parham
We believe that this is the first translation into English of the first description, in French, of a disease previously unknown. JL Riopelle and JP Thériault, both pathologists, reviewed clinical and pathologic findings in six young patients with soft tissue tumors, and contributed autopsy information on four of the patients. Only one patient was initially correctly diagnosed with rhabdomyosarcoma; the other five initially had alternative diagnoses. Because of space limitations, we have condensed the clinical and pathologic details of their 23-page, approximately 9-font article into two Tables, but have otherwise translated the complete text of this seminal paper...
September 2012: Pediatric and Developmental Pathology
https://www.readbyqxmd.com/read/22507948/outcomes-of-hiv-infected-patients-treated-for-recurrent-tuberculosis-with-the-standard-retreatment-regimen
#16
J McGreevy, M A Jean Juste, P Severe, S Collins, S Koenig, J W Pape, D W Fitzgerald
SETTING: The Groupe Haitien d'Etude du Sarcome de Kaposi et des Infections Opportunistes (the GHESKIO AIDS and TB Center) in Port-au-Prince, Haiti. OBJECTIVE: To measure the effectiveness of the standard TB retreatment regimen (2HRZES/1HRZE/5HRE) in human immunodeficiency virus (HIV) infected adults. DESIGN: Cohort study. RESULTS: Of 1318 HIV-infected patients with access to antiretroviral therapy following World Health Organization guidelines, 56 were diagnosed with recurrent pulmonary TB and retreated with the standard retreatment regimen: 10 patients (18%) died during retreatment, 3 (5%) defaulted, and 2 (4%) failed treatment...
June 2012: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/22395512/vascular-and-mesenchymal-factors-during-heart-development-a-chronological-study
#17
I D Marinaş, Raluca Marinaş, Ionica Pirici, L Mogoantă
As heart development is an incomplete described area, and likewise an important source of intra- and post-partum morbidity and mortality, we have aimed at analyzing both vascular and cytoskeletal factors during early heart development in humans. The distribution of CD105, CD31, α-SMA, vimentin and desmin have been studied on a series of normal human heart tissues varying between five and 33 weeks of gestational age, utilizing both enzymatic single immunohistochemistry, as well as double immunofluorescence...
2012: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/22378328/growth-in-late-infancy-among-hiv-exposed-children-in-urban-haiti-is-associated-with-participation-in-a-clinic-based-infant-feeding-support-intervention
#18
MULTICENTER STUDY
Rebecca A Heidkamp, Rebecca J Stoltzfus, Daniel W Fitzgerald, Jean W Pape
The integration of nutrition support for infants of HIV-infected mothers is a recognized need; however, the evidence for effective programmatic solutions is weak. The objective of our study was to implement and evaluate a new infant feeding support intervention for HIV-exposed, uninfected, non-breast-fed infants 6-12 mo of age attending the Groupe Haïtien d'Etude du Sarcome de Kaposi et des Infections Opportunistes (GHESKIO) pediatric clinic in Port-au-Prince, Haiti. The 24-wk intervention included a lipid-based nutrient supplement, education, promotion of existing clinical services, and social support...
April 2012: Journal of Nutrition
https://www.readbyqxmd.com/read/22293975/histological-and-ultrastructural-abnormalities-in-murine-desmoglein-2-mutant-hearts
#19
Sebastian Kant, Philipp Krull, Sabine Eisner, Rudolf E Leube, Claudia A Krusche
Mice carrying a deletion of the adhesive extracellular domain of the desmosomal cadherin desmoglein 2 develop an arrhythmogenic right ventricular cardiomyopathylike phenotype with ventricular dilation, fibrosis and arrhythmia. To unravel the sequence of myocardial alterations and to identify potential pathomechanisms, histological analyses were performed on mutant hearts from the juvenile to the adult state, i.e., between 2 and 13 weeks. At an age of 2 weeks 30% of mutants presented lesions,which were visible as white plaques on the heart surface or in the septum...
May 2012: Cell and Tissue Research
https://www.readbyqxmd.com/read/21194407/respiratory-muscle-dysfunction-in-copd-from-muscles-to-cell
#20
REVIEW
M Klimathianaki, K Vaporidi, D Georgopoulos
Respiratory muscle dysfunction is a cardinal feature of acute and chronic respiratory failure in COPD. Diaphragm and accessory inspiratory muscles face increased load due to increased lung resistance and elastance, as well as increased ventilatory demands. Concomitantly, the capacity of the inspiratory muscles to generate pressure is decreased due to mechanical disadvantage imposed by hyperinflation. Additionally, inflammation and oxidative stress impair muscle fiber specific force generation and increase diaphragm susceptibility to sarcomer disruption during acute inspiratory loading...
April 2011: Current Drug Targets
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