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https://www.readbyqxmd.com/read/27999015/a-single-dose-of-epidermicin-ni01-is-sufficient-to-eradicate-mrsa-from-the-nares-of-cotton-rats
#1
Samantha Halliwell, Peter Warn, Abdul Sattar, Jeremy P Derrick, Mathew Upton
OBJECTIVES: To investigate the efficacy of a potent novel antimicrobial protein of mass 6 kDa, epidermicin NI01, for eradicating the nasal burden of MRSA in a cotton rat (Sigmodon hispidus) model. METHODS: MRSA strain ATCC 43300 was used to establish a robust colonization of cotton rat nares. This model was used to evaluate the efficacy of topical 0.04% and 0.2% epidermicin NI01, administered twice daily for 3 days consecutively, and topical 0.8% epidermicin NI01 administered once, for reducing nasal MRSA burden...
December 20, 2016: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/27995243/nano-layered-magnesium-fluoride-reservoirs-on-biomaterial-surfaces-strengthen-polymorphonuclear-leukocyte-resistance-to-bacterial-pathogens
#2
Geyong Guo, Huaijuan Zhou, Qiaojie Wang, Jiaxing Wang, Jiaqi Tan, Jinhua Li, Ping Jin, Hao Shen
Biomaterial-related bacterial infections cause patient suffering, mortality and extended periods of hospitalization, imposing a substantial burden on medical systems. In this context, understanding of nanomaterials-bacteria-cells interactions is of both fundamental and clinical significance. Herein, nano-MgF2 films were deposited on titanium substrate via magnetron sputtering. Using this platform, the antibacterial behavior and mechanism of the nano-MgF2 films were investigated in vitro and in vivo. It was found that, for S...
December 20, 2016: Nanoscale
https://www.readbyqxmd.com/read/27855064/rifampin-based-combination-therapy-is-active-in-foreign-body-osteomyelitis-after-prior-rifampin-monotherapy
#3
Cassandra L Brinkman, Suzannah M Schmidt-Malan, Jayawant N Mandrekar, Robin Patel
Staphylococcal prosthetic joint infections (PJIs) are associated with biofilm formation, making them difficult to treat; if managed with débridement and implant retention, rifampin-based therapy is usually employed. Rifampin resistance potentially challenges PJI treatment. In investigating the effects of rifampin monotherapy on methicillin-resistant Staphylococcus aureus (MRSA) foreign body osteomyelitis in rats, we previously demonstrated that rifampin resistance was selected but that it disappeared 14 days following rifampin monotherapy (1) and that rifampin resistance occurred less frequently following two rounds than one round of rifampin monotherapy (2)...
November 14, 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27799220/covalent-immobilization-of-enoxacin-onto-titanium-implant-surfaces-for-inhibiting-multiple-bacterial-species-infection-and-in-vivo-methicillin-resistant-staphylococcus-aureus-infection-prophylaxis
#4
Bin'en Nie, Teng Long, Haiyong Ao, Jianliang Zhou, Tingting Tang, Bing Yue
Infection is one of the most important causes of titanium implant failure in vivo A developing prophylactic method involves the immobilization of antibiotics, especially vancomycin, onto the surface of the titanium implant. However, these methods have a limited effect in curbing multiple bacterial infections due to antibiotic specificity. In the current study, enoxacin was covalently bound to an amine-functionalized Ti surface by use of a polyethylene glycol (PEG) spacer, and the bactericidal effectiveness was investigated in vitro and in vivo The titanium surface was amine functionalized with 3-aminopropyltriethoxysilane (APTES), through which PEG spacer molecules were covalently immobilized onto the titanium, and then the enoxacin was covalently bound to the PEG, which was confirmed by X-ray photoelectron spectrometry (XPS)...
January 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27770905/effect-of-gelatin-sponge-with-colloid-silver-on-bone-healing-in-infected-cranial-defects
#5
Yuliang Dong, Weiqing Liu, Yiling Lei, Tingxi Wu, Shiwen Zhang, Yuchen Guo, Yuan Liu, Demeng Chen, Quan Yuan, Yongyue Wang
Oral infectious diseases may lead to bone loss, which makes it difficult to achieve satisfactory restoration. The rise of multidrug resistant bacteria has put forward severe challenges to the use of antibiotics. Silver (Ag) has long been known as a strong antibacterial agent. In clinic, gelatin sponge with colloid silver is used to reduce tooth extraction complication. To investigate how this material affect infected bone defects, methicillin-resistant Staphylococcus aureus (MRSA) infected 3-mm-diameter cranial defects were created in adult female Sprague-Dawley rats...
January 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27760665/-effect-of-quorum-sensing-system-on-the-infection-of-mrsa-and-the-intervention-of-erythromycin-on-it
#6
H Y Shi, Q D Li, X Y Wan
Objective: To investigate the destructive effects of erythromycin on biofilm of MRSA and find the effect of erythromycin on QS related factors. Methods: Tested the MBC of erythromycin on MRSA.Established the model of biofilm.Erythromycin was added into the medium when bacteria were inoculated for 24 h. Tested the biofilm and collected the supernatant or serum of rat at 6, 12, 24, 48, 72 h and 7 d after adding erythromycin to detect the concentration of autoinducing peptides (AIP). Results: The MBC of the erythromycin on standard strains of MRSA was 256 g/L...
October 11, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/27709890/a-biodegradable-polycationic-paint-that-kills-bacteria-in-vitro-and-in-vivo
#7
Jiaul Hoque, Padma Akkapeddi, Chandradhish Ghosh, Divakara S S M Uppu, Jayanta Haldar
Bacterial colonization and subsequent formation of biofilms onto surfaces of medical devices and implants is a major source of nosocomial infections. Most antibacterial coatings to combat infections are either metal-based or nondegradable-polymer-based and hence limited by their nondegradability and unpredictable toxicity. Moreover, to combat infections effectively, the coatings are required to display simultaneous antibacterial and antibiofilm activity. Herein we report biocompatible and biodegradable coatings based on organo-soluble quaternary chitin polymers which were immobilized noncovalently onto surfaces as bactericidal paint...
November 2, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27639707/the-anti-biofilm-effect-of-macrolides-in-a-rat-model-of-s-aureus-foreign-body-infection-might-it-be-of-clinical-relevance
#8
Cristina El Haj, Oscar Murillo, Alba Ribera, Dolors Garcia-Somoza, Fe Tubau, Carmen Cabellos, Javier Cabo, Javier Ariza
Using a tissue cage infection rat model, we test the anti-biofilm effect of clarithromycin on the efficacy of daptomycin and a daptomycin + rifampicin combination against methicillin-susceptible (MSSA) and methicillin-resistant Staphylococcus aureus (MRSA). In vitro: kill curves, daptomycin exposure studies and clarithromycin activity against biofilm were studied. In vivo: the efficacies of clarithromycin, daptomycin or daptomycin + clarithromycin, daptomycin + rifampicin and daptomycin + rifampicin + clarithromycin combinations were evaluated...
September 17, 2016: Medical Microbiology and Immunology
https://www.readbyqxmd.com/read/27637169/tlr-and-nlrp3-inflammasome-expression-deregulation-in-macrophages-of-adult-rats-subjected-to-neonatal-malnutrition-and-infected-with-methicillin-resistant-staphylococcus-aureus
#9
Natália Gomes de Morais, Thacianna Barreto da Costa, Joana Maria Bezerra de Lira, Suênia da Cunha Gonçalves de Albuquerque, Valéria Rêgo Alves Pereira, Milena de Paiva Cavalcanti, Célia Maria Machado Barbosa de Castro
OBJECTIVES: Nutritional aggression in critical periods may lead to epigenetic changes that affect gene expression. The aim of this study was to assess the effect of neonatal malnutrition on the expression of toll-like receptor (TLR)-2, TLR-4, and NLRP3 receptors, caspase-1 enzyme, and interleukin (IL)-1 β production in macrophages infected with methicillin-resistant (MRSA) and methicillin-sensitive (MSSA) Staphylococcus aureus. METHODS: Wistar rats (N = 24) were divided in two distinct groups: nourished (17% casein) and malnourished (8% casein)...
January 2017: Nutrition
https://www.readbyqxmd.com/read/27550347/activity-of-tedizolid-in-methicillin-resistant-staphylococcus-aureus-experimental-foreign-body-associated-osteomyelitis
#10
Kyung-Hwa Park, Kerryl E Greenwood-Quaintance, Jayawant Mandrekar, Robin Patel
We compared tedizolid alone and tedizolid with rifampin to rifampin and vancomycin plus rifampin in a rat model of methicillin-resistant Staphylococcus aureus (MRSA) foreign body-associated osteomyelitis. The study strain was a prosthetic joint infection-associated isolate. Steady-state pharmacokinetics for intraperitoneal administration of tedizolid, vancomycin, and rifampin were determined in uninfected rats. MRSA was inoculated into the proximal tibia, and a wire was implanted. Four weeks later, the rats were treated intraperitoneally for 21 days with tedizolid (n = 14), tedizolid plus rifampin (n = 11), rifampin (n = 16), or vancomycin plus rifampin (n = 13)...
November 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27526720/small-antimicrobial-agents-based-on-acylated-reduced-amide-scaffold
#11
Peng Teng, Da Huo, Alekhya Nimmagadda, Jianfeng Wu, Fengyu She, Ma Su, Xiaoyang Lin, Jiyu Yan, Annie Cao, Chuanwu Xi, Yong Hu, Jianfeng Cai
Prevalence of drug-resistant bacteria has emerged to be one of the greatest threats in the 21st century. Herein, we report the development of a series of small molecular antibacterial agents that are based on the acylated reduced amide scaffold. These molecules display good potency against a panel of multidrug-resistant Gram-positive and Gram-negative bacterial strains. Meanwhile, they also effectively inhibit the biofilm formation. Mechanistic studies suggest that these compounds kill bacteria by compromising bacterial membranes, a mechanism analogous to that of host-defense peptides (HDPs)...
September 8, 2016: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27472197/local-intramedullary-delivery-of-vancomycin-can-prevent-the-development-of-long-bone-staphylococcus-aureus-infection
#12
Catherine Loc-Carrillo, Caroline Wang, Ahranee Canden, Michael Burr, Jayant Agarwal
Current treatments for methicillin-resistant Staphylococcus aureus (MRSA) infections require intravenously delivered vancomycin; however, systemically delivered vancomycin has its problems. To determine the feasibility and safety of locally delivering vancomycin hydrochloride (~25 mg/Kg) to the medullary canal of long bones, we conducted a pharmacokinetics study using a rat tibia model. We found that administering the vancomycin intraosseously resulted in very low concentrations of vancomycin in the blood plasma and the muscle surrounding the tibia, reducing the risk for systemic toxicity, which is often seen with traditional intravenous administration of vancomycin...
2016: PloS One
https://www.readbyqxmd.com/read/27448287/synthesis-of-self-assembled-spermidine-carbon-quantum-dots-effective-against-multidrug-resistant-bacteria
#13
Yu-Jia Li, Scott G Harroun, Yu-Chia Su, Chun-Fang Huang, Binesh Unnikrishnan, Han-Jia Lin, Chia-Hua Lin, Chih-Ching Huang
This study reports a two-step method to synthesize spermidine-capped fluorescent carbon quantum dots (Spd-CQDs) and their potential application as an antibacterial agent. Fluorescent carbon quantum dots (CQDs) are synthesized by pyrolysis of ammonium citrate in the solid state and then modified with spermidine by a simple heating treatment without a coupling agent. Spermidine, a naturally occurring polyamine, binds with DNA, lipids, and proteins involved in many important processes within organisms such as DNA stability, and cell growth, proliferation, and death...
October 2016: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/27393432/potential-role-of-saudi-red-propolis-in-alleviating-lung-damage-induced-by-methicillin-resistant-staphylococcus-aureus-virulence-in-rats
#14
Amna Ali Saddiq, Azza Mostafa Mohamed
The aim of this study was to explore the protective impact of aqueous extract of Saudi red propolis against rat lung damage induced by the pathogenic bacteria namely methicillin resistant Staphylococcus aureus (MRSA) ATCC 6538 strain. Infected rats were received a single intraperitoneal (i.p.) injection of bacterial suspension at a dose of 1 X 10(6) CFU / 100g body weight. Results showed that oral administration of an aqueous extract of propolis (50mg/100g body weight) daily for two weeks to infected rats simultaneously with bacterial infection, effectively ameliorated the alteration of oxidative stress biomarker, malondialdehyde (MDA), as well as the antioxidant markers, glutathione peroxidase (GPx) and superoxide dismutase (SOD), in lungs of infected rats compared with infected untreated ones...
July 2016: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27366751/efficacy-of-linezolid-and-fosfomycin-in-catheter-related-biofilm-infection-caused-by-methicillin-resistant-staphylococcus-aureus
#15
Dong Chai, Xu Liu, Rui Wang, Yan Bai, Yun Cai
As long-standing clinical problems, catheter-related infections and other chronic biofilm infections are more difficult to treat due to the high antibiotic resistance of biofilm. Therefore, new treatments are needed for more effective bacteria clearance. In this study, we evaluated the antibacterial activities of several common antibiotics alone and their combinations against biofilm-embedded methicillin-resistant staphylococcus aureus (MRSA) infections, both in vitro and in vivo. In brief, fosfomycin, levofloxacin, and rifampin alone or in combination with linezolid were tested in vitro against planktonic and biofilm-embedded MRSA infection in three MRSA stains...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27353266/in-vitro-and-in-vivo-effectiveness-of-an-innovative-silver-copper-nanoparticle-coating-of-catheters-to-prevent-methicillin-resistant-staphylococcus-aureus-infection
#16
Myriam K S Ballo, Sami Rtimi, César Pulgarin, Nancy Hopf, Aurélie Berthet, John Kiwi, Philippe Moreillon, José M Entenza, Alain Bizzini
In this study, silver/copper (Ag/Cu)-coated catheters were investigated for their efficacy in preventing methicillin-resistant Staphylococcus aureus (MRSA) infection in vitro and in vivo Ag and Cu were sputtered (67/33% atomic ratio) on polyurethane catheters by direct-current magnetron sputtering. In vitro, Ag/Cu-coated and uncoated catheters were immersed in phosphate-buffered saline (PBS) or rat plasma and exposed to MRSA ATCC 43300 at 10(4) to 10(8) CFU/ml. In vivo, Ag/Cu-coated and uncoated catheters were placed in the jugular vein of rats...
September 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27275854/antibacterial-properties-and-healing-effects-of-melipona-scutellaris-honey-in-mrsa-infected-wounds-of-rats
#17
Vanessa de Fátima Lima Paiva Medeiros, Ítalo Medeiros Azevedo, Amália Cínthia Meneses Rêgo, Eryvaldo Sócrates Tabosa do Egito, Irami Araújo-Filho, Aldo Cunha Medeiros
PURPOSE: To investigate the antimicrobial, immunological and healing effects of Melipona scutellaris honey on infected wounds of rat skin. METHODS: Twenty four Wistar rats were distributed in four groups (6-each). The uninfected skin wounds of group I rats were treated daily with saline for 7 days. Uninfected wounds (group II) rats were treated with honey. In group III (treated with saline) and group IV (treated with honey) wounds were inoculated with MRSA ATTC43300...
May 2016: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/27208868/treatment-for-diabetic-ulcer-wounds-using-a-fern-tannin-optimized-hydrogel-formulation-with-antibacterial-and-antioxidative-properties
#18
Jordan Chia-Yung Lai, How-Yee Lai, Nalamolu Koteswara Rao, Shiow-Fern Ng
ETHNOPHARMACOLOGICAL RELEVANCE: Blechnum orientale Linn. (B. orientale) is a fern traditionally used by the natives as a poultice to treat wounds, boils, ulcers, blisters, abscesses, and sores on the skin. AIM OF THE STUDY: To investigate the wound healing ability of a concentrated extract of B. orientale in a hydrogel formulation in healing diabetic ulcer wounds. MATERIALS AND METHODS: The water extract from the leaves of B. orientale was separated from the crude methanolic extract and subjected to flash column chromatography techniques to produce concentrated fractions...
August 2, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27155369/anti-infective-efficacy-of-the-lactoferrin-derived-antimicrobial-peptide-hlr1r
#19
Camilla Björn, Margit Mahlapuu, Inger Mattsby-Baltzer, Joakim Håkansson
Antimicrobial peptides (AMPs) have emerged as a new class of drug candidates for the treatment of infectious diseases. Here we describe a novel AMP, HLR1r, which is structurally derived from the human milk protein lactoferrin and demonstrates a broad spectrum microbicidal action in vitro. The minimum concentration of HLR1r needed for killing ≥99% of microorganisms in vitro, was in the range of 3-50μg/ml for common Gram-negative and Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA), and for the yeast Candida albicans, when assessed in diluted brain-heart infusion medium...
July 2016: Peptides
https://www.readbyqxmd.com/read/26973620/mechanism-and-in-vivo-evaluation-photodynamic-antibacterial-chemotherapy-of-lysine-porphyrin-conjugate
#20
Zengping Xu, Yuxiang Gao, Shuai Meng, Baochen Yang, Liyun Pang, Chen Wang, Tianjun Liu
Lysine-porphyrin conjugate 4i has potent photosensitive antibacterial effect on clinical isolated bacterial strains such as Methicillin-resistant Staphylococcus aureus (MRSA), Escherichia coli, and Pseudomonas aeruginosa. The mechanism of photodynamic antibacterial chemotherapy of 4i (4i-PACT) in vitro and the treatment effect in vivo was investigated in this paper. Atomic force microscopy (AFM) revealed that 4i-PACT can effectively destroy membrane and wall of bacteria, resulting in leakage of its content...
2016: Frontiers in Microbiology
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