Alexander R Berg, Christin G Hong, Maryia Svirydava, Haiou Li, Philip M Parel, Elizabeth Florida, Ross O'Hagan, Carla J Pantoja, Sundus S Lateef, Paula Anzenberg, Charlotte L Harrington, Grace Ward, Wunan Zhou, Alexander V Sorokin, Marcus Y Chen, Heather L Teague, Andrew J Buckler, Martin P Playford, Joel M Gelfand, Nehal N Mehta
Psoriasis is a systemic inflammatory disease with an increased risk of atherosclerotic events and premature cardiovascular disease. S100A7, A8/A9, and A12 are protein complexes that are produced by activated neutrophils, monocytes, and keratinocytes in psoriasis. Lipid-rich necrotic core (LRNC) is a high-risk coronary plaque feature previously found to be associated with cardiovascular risk factors and psoriasis severity. LRNC can decrease with biologic therapy, but how this occurs remains unknown. We investigated the relationship between S100 proteins, LRNC, and biologic therapy in psoriasis...
June 21, 2022: Journal of Investigative Dermatology