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Serum S100A12

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https://www.readbyqxmd.com/read/27914132/associations-between-soluble-receptor-for-advanced-glycation-end-products-srage-and-s100a12-en-rage-with-mortality-in-long-term-hemodialysis-patients
#1
Eul Sik Jung, Wookyung Chung, Ae Jin Kim, Han Ro, Jae Hyun Chang, Hyun Hee Lee, Ji Yong Jung
Hemodialysis (HD) patients experience vascular calcification, ultimately leading to high mortality rates. Previously, we reported associations between soluble receptor for advanced glycation end products (sRAGEs) and extracellular newly identified RAGE-binding protein S100A12 (EN-RAGE) and vascular calcification. Here, we extended our observations, investigating whether these biomarkers may be useful for predicting cardiovascular morbidity and mortality in these subjects. Thus, we evaluated the relationship between sRAGE and S100A12 and mortality in long-term HD patients...
January 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/27836422/surgical-necrotizing-enterocolitis
#2
REVIEW
Jamie R Robinson, Eric J Rellinger, L Dupree Hatch, Joern-Hendrik Weitkamp, K Elizabeth Speck, Melissa Danko, Martin L Blakely
Although currently available data are variable, it appears that the incidence of surgical necrotizing enterocolitis (NEC) has not decreased significantly over the past decade. Pneumoperitoneum and clinical deterioration despite maximal medical therapy remain the most common indications for operative treatment. Robust studies linking outcomes with specific indications for operation are lacking. Promising biomarkers for severe NEC include fecal calprotectin and S100A12; serum fatty acid-binding protein; and urine biomarkers...
November 8, 2016: Seminars in Perinatology
https://www.readbyqxmd.com/read/27689623/alarmins-and-clinical-outcomes-after-major-abdominal-surgery-a-prospective-study
#3
Jan Máca, Filip Burša, Pavel Ševčík, Peter Sklienka, Michal Burda, Michal Holub
PURPOSE: Tissue injury causing immune response is an integral part of surgical procedure. Evaluation of the degree of surgical trauma could help to improve postoperative management and determine the clinical outcomes. MATERIALS AND METHODS: We analyzed serum levels of alarmins, including S100A5, S100A6, S100A8, S100A9, S100A11, and S100A12; high-mobility group box 1; and heat-shock protein 70, after elective major abdominal surgery (n = 82). Blood samples were collected for three consecutive days after surgery...
September 30, 2016: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/27539060/s100a12-is-up-regulated-in-pulmonary-tuberculosis-and-predicts-the-extent-of-alveolar-infiltration-on-chest-radiography-an-observational-study
#4
Luis C Berrocal-Almanza, Surabhi Goyal, Abid Hussain, Tilman E Klassert, Dominik Driesch, Zarko Grozdanovic, Gadamm Sumanlatha, Niyaz Ahmed, Vijayalakshmi Valluri, Melanie L Conrad, Nickel Dittrich, Ralf R Schumann, Birgit Lala, Hortense Slevogt
Pulmonary tuberculosis (PTB) results in lung functional impairment and there are no surrogate markers to monitor the extent of lung involvement. We investigated the clinical significance of S100A12 and soluble receptor for advanced glycation end-products (sRAGE) for predicting the extent of lung involvement. We performed an observational study in India with 119 newly diagnosed, treatment naïve, sputum smear positive, HIV-negative PTB patients and 163 healthy controls. All patients were followed-up for six months...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27493063/inflammation-associated-cytokine-analysis-identifies-presence-of-respiratory-bacterial-pathogens-in-the-nasopharynx
#5
Michael E Pichichero, Anthony Almudevar
We sought to determine if inflammatory cytokines are induced during asymptomatic nasopharyngeal (NP) colonization by the common respiratory bacteria Streptococcus pneumoniae (Spn), non-typeable Haemophilus influenzae (NTHi) and Moraxella catarrhalis (Mcat). 85 serum samples were studied from 85 children 6-36 months of age when children were healthy and potentially NP colonized with Spn, NTHi or Mcat. Immunoassays were used to quantitate serum sICAM-1, IL-10 and S100A12 levels. Logistic regression was used to develop a predictive model for NP colonization probability for causative bacterial pathogen presence...
August 2016: Pathogens and Disease
https://www.readbyqxmd.com/read/27407135/pro-inflammatory-s100-proteins-are-associated-with-glomerulonephritis-and-anti-dsdna-antibodies-in-systemic-lupus-erythematosus
#6
H Tydén, C Lood, B Gullstrand, A Jönsen, F Ivars, T Leanderson, A A Bengtsson
OBJECTIVES: Systemic lupus erythematosus (SLE) is associated with elevated levels of S100A8/A9, pro-inflammatory proteins mainly secreted by activated polymorphonuclear neutrophils (PMNs). The underlying mechanisms for increased S100A8/A9 levels and their relation to the clinical phenotype have not been carefully investigated. We assessed S100A8/A9 and S100A12 levels in SLE patient sera in relation to disease activity, clinical phenotype, presence of anti-dsDNA antibodies and ability to promote phagocytosis of necrotic cells (NCs) by PMNs...
July 12, 2016: Lupus
https://www.readbyqxmd.com/read/27333294/secretory-activity-of-neutrophils-correlates-with-genotype-in-familial-mediterranean-fever
#7
Faekah Gohar, Banu Orak, Tilmann Kallinich, Marion Jeske, Mareike Lieber, Horst von Bernuth, Arnd Giese, Elisabeth Weissbarth-Riedel, Johannes-Peter Haas, Frank Dressler, Dirk Holzinger, Peter Lohse, Ulrich Neudorf, Elke Lainka, Claas Hinze, Katja Masjosthusmann, Christoph Kessel, Toni Weinhage, Dirk Foell, Helmut Wittkowski
Objectives Familial Mediterranean Fever (FMF) is an autoinflammatory disorder caused by pyrin-encoding MEFV gene mutations. Patients present with recurrent but self-limiting episodes of acute inflammation and often have persistent subclinical inflammation. The pathophysiology is only partially understood, but neutrophil overactivation is a hallmark of the disease. S100A12 is a neutrophil-derived pro-inflammatory danger signal that is strongly elevated in active FMF. We characterised neutrophilic secretory activity in vitro and investigated the association of S100A12 with disease activity and genotype in FMF patients...
June 22, 2016: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/27296263/-serum-calgranulin-c-is-a-highly-sensitive-autoinflammation-activity-indicator-in-patients-with-familial-periodic-fevers
#8
M V Bogdanova, V V Rameev, L V Kozlovskaya, E S Fedorov, S O Salugina
AIM: To determine the possibility of using the serum proinflammatory calcium-binding protein, or calgranulin C (S100A12), to assess activity and therapeutic efficiency in patients with periodic disease (PD) and other familial periodic fevers (FPFs). SUBJECTS AND METHODS: Thirty-five patients with PD and other FPDs, which were verified by molecular genetic study, were examined. In accordance with the disease activity, the patients were divided into 2 groups. The investigators determined the concentration of S100A12 by solid-phase enzyme immunoassay and that of other acute-phase inflammatory markers (erythrocyte sedimentation rate (ERT), neutrophil counts, and fibrinogen and C-reactive protein (CRP) concentrations)...
2016: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/27271454/serum-c-reactive-protein-and-s100a12-concentrations-in-dogs-with-hepatic-disease
#9
S M Craig, J K Fry, A Rodrigues Hoffmann, P Manino, R M Heilmann, J S Suchodolski, J M Steiner, H A Hottinger, S L Hunter, J A Lidbury
OBJECTIVES: To describe serum C-reactive protein and S100A12 concentrations in dogs with hepatic disease and to determine whether there is a relationship between the concentration of either and the severity of hepatic necroinflammation. METHODS: Serum C-reactive protein and S100A12 concentrations were measured in 46 dogs undergoing hepatic biopsy. Dogs were divided into three groups: congenital portosystemic shunts, chronic hepatitis and hepatic neoplasia. The histological severity of hepatic necroinflammation was scored...
September 2016: Journal of Small Animal Practice
https://www.readbyqxmd.com/read/27251034/effect-of-s100a12-and-soluble-receptor-for-advanced-glycation-end-products-on-the-occurrence-of-severe-acute-pancreatitis
#10
Bing Zhao, Ying Chen, Wen Wu Sun, Wei Wei Chen, Li Ma, Zhi Tao Yang, Jun Huang, Er Zhen Chen, Jian Fei, En Qiang Mao
OBJECTIVE: To assess whether serum levels of S100A12 and soluble receptor for advanced glycation end products (sRAGE) could predict the severity of acute pancreatitis (AP). METHODS: We conducted a non-interventional pilot study, including 74 AP patients and 28 healthy volunteers serving as controls. AP patients were further divided into the mild (MAP, n = 22), moderately severe (MSAP, n = 30) and severe (SAP, n = 22) groups. Peripheral blood samples were collected within 72 h after the onset of AP for the determination of S100A12, sRAGE and C-reactive protein (CRP) levels...
July 2016: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/27182898/ten-year-study-of-acute-otitis-media-in-rochester-ny
#11
Michael E Pichichero
This review summarizes a prospective, longitudinal 10-year study in Rochester, NY, involving 760 children where virtually all clinically diagnosed acute otitis media (AOM) was confirmed by bacterial culture of middle ear fluid. This review describes detection of otopathogens in middle ear fluid, nasopharyngeal (NP) otopathogen colonization patterns, AOM risk factor analysis, biomarkers of AOM and antibody responses to NP colonization by otopathogens. After licensure of PCV13, there was an immediate drop in AOM caused by Streptococcus pneumoniae (Spn) vaccine serotypes and shortly thereafer an increase in nonvaccine types 16, 21 and 35B...
September 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/26975751/utility-of-surrogate-markers-for-the-prediction-of-relapses-in-inflammatory-bowel-diseases
#12
REVIEW
Jason Orlando Dimitri Musci, Jack Stephen Cornish, Jan Däbritz
Patients with diagnosed inflammatory bowel disease (IBD) will commonly experience a clinical relapse in spite of a prolonged therapy-induced period of clinical remission. The current methods of assessing subclinical levels of low-grade inflammation which predispose patients to relapse are not optimal when considering both cost and patient comfort. Over the past few decades, much investigation has discovered that proteins such as calprotectin that are released from inflammatory cells are capable of indicating disease activity...
June 2016: Journal of Gastroenterology
https://www.readbyqxmd.com/read/26968077/serum-cytokine-biomarkers-accurately-predict-presence-of-acute-otitis-media-infection-and-recovery-caused-by-haemophilus-influenzae
#13
Michael E Pichichero, Anthony Almudevar
OBJECTIVE: We sought to develop an optimal model using a combination of serum biomarker pro-inflammatory and dampening inflammatory cytokine proteins to predict the presence of acute otitis media (AOM) infection and recovery caused by Nontypeable Haemophilus influenzae (NTHi). METHODS: 88 serum samples were studied from 34 children 6-36 months of age at healthy visits, at onset of AOM diagnosed by qualified pediatricians and confirmed by tympanocentesis to be caused by NTHi and follow up 3 weeks to 4 months later...
April 2016: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/26914918/circulating-s100a12-levels-are-associated-with-progression-of-abdominal-aortic-calcification-in-hemodialysis-patients
#14
Byoung Ho Choi, Han Ro, Eul Sik Jung, Ae Jin Kim, Jae Hyun Chang, Hyun Hee Lee, Wookyung Chung, Ji Yong Jung
Vascular calcification is an important factor associated with mortality in dialysis patients. Recently, soluble receptor for advanced glycation end product (sRAGE) and extracellular RAGE binding protein S100A12 (EN-RAGE) have been reported to be involved in the process of vascular calcification. Therefore, we investigated whether sRAGE and S100A12 are useful indicators of progression of abdominal aortic calcification in hemodialysis (HD) patients. We analyzed annual changes in vascular calcification score (VCS) for up to 4 years, compared to clinical and biological parameters in 149 HD patients...
2016: PloS One
https://www.readbyqxmd.com/read/26765807/validation-of-an-enzyme-linked-immunosorbent-assay-elisa-for-the-measurement-of-canine-s100a12
#15
Romy M Heilmann, Shannon M Cranford, Andy Ambrus, Niels Grützner, Stefan Schellenberg, Craig G Ruaux, Jan S Suchodolski, Jörg M Steiner
BACKGROUND: Canine S100 calcium-binding protein A12 (cS100A12) shows promise as biomarker of inflammation in dogs. A previously developed cS100A12-radioimmunoassay (RIA) requires radioactive tracers and is not sensitive enough for fecal cS100A12 concentrations in 79% of tested healthy dogs. An ELISA assay may be more sensitive than RIA and does not require radioactive tracers. OBJECTIVE: The purpose of the study was to establish a sandwich ELISA for serum and fecal cS100A12, and to establish reference intervals (RI) for normal healthy canine serum and feces...
March 2016: Veterinary Clinical Pathology
https://www.readbyqxmd.com/read/26653550/diagnostic-importance-of-s100a9-and-s100a12-in-breast-cancer
#16
Meral Gunaldi, Yildiz Okuturlar, Asuman Gedikbasi, Cevher Akarsu, Mehmet Karabulut, Alev Kural
BACKGROUND: The most frequent cause of cancer deaths throughout the world is breast cancer (BC). Therefore, preventing, diagnosing and treating BC has gained importance. S100 protein probably plays an important role in carcinogenesis, cancer development, and metastasis. In this study, we aimed at diagnostic and clinic-pathological importance of serum levels of S100A9 and S100A12 with known cytokine-like pro-inflammatory effects in BC. MATERIAL AND METHOD: Serum samples were collected with BC and the control group consisting of healthy individuals...
December 2015: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/26624497/elevated-s100a8-a9-and-s100a12-serum-levels-reflect-intraocular-inflammation-in-juvenile-idiopathic-arthritis-associated-uveitis-results-from-a-pilot-study
#17
Karoline Walscheid, Arnd Heiligenhaus, Dirk Holzinger, Johannes Roth, Carsten Heinz, Christoph Tappeiner, Maren Kasper, Dirk Foell
PURPOSE: Juvenile idiopathic arthritis-associated uveitis (JIAU) is the most common uveitis entity in childhood. As S100A8/A9 and S100A12 proteins are valuable biomarkers in childhood arthritis, we investigated the occurrence of these proteins in childhood uveitis. METHODS: Serum samples from patients with JIAU (n = 79) or idiopathic anterior uveitis (IAU, n = 24), as well as from nonuveitic controls (n = 24), were collected. Furthermore, aqueous humor samples (JIAU n = 17, nonuveitic controls n = 16, IAU n = 12) were obtained...
December 2015: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/26523111/are-faecal-markers-good-indicators-of-mucosal-healing-in-inflammatory-bowel-disease
#18
REVIEW
Gudula Jam Boon, Andrew S Day, Chris J Mulder, Richard B Gearry
AIM: To review the published literature concerning the accuracy of faecal inflammatory markers for identifying mucosal healing. METHODS: Bibliographical searches were performed in MEDLINE electronic database up to February 2015, using the following terms: "inflammatory bowel disease", "Crohn's disease", "ulcerative colitis", "faecal markers", "calprotectin", "lactoferrin", "S100A12", "endoscop*", "mucosal healing", "remission". In addition, relevant references from these studies were also included...
October 28, 2015: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/26512051/sleep-fragmentation-and-biomarkers-in-juvenile-idiopathic-arthritis
#19
Teresa M Ward, Weichao Yuwen, Joachim Voss, Dirk Foell, Faekah Gohar, Sarah Ringold
OBJECTIVES: (1) To compare sleep (nighttime sleep duration and sleep efficiency) and sleep fragmentation (movement and fragmentation index), as measured by actigraphy, and symptoms (pain and fatigue) in 8- to 14-year-old children with polyarticular and extended oligoarticular juvenile idiopathic arthritis (JIA) and (2) to examine the associations between sleep fragmentation (movement and fragmentation index) and the calcium-binding protein biomarkers S100A12 and myeloid-related protein (MRP8/14)...
May 2016: Biological Research for Nursing
https://www.readbyqxmd.com/read/26486615/increased-serum-concentrations-of-neutrophil-derived-protein-s100a12-in-heterozygous-carriers-of-mefv-mutations
#20
Mareike Lieber, Tilmann Kallinich, Peter Lohse, Jens Klotsche, Dirk Holzinger, Dirk Foell, Helmut Wittkowski
OBJECTIVES: To assess subclinical inflammation in heterozygous carriers of Mediterranean fever (MEFV) gene mutations, analysis of classical inflammation markers and S100A12 was performed. METHODS: Exons 2, 3, and 10 of the MEFV gene, C-reactive protein (CRP), serum amyloid A protein (SAA), procalcitonin (PCT), and S100A12 concentrations, erythrocyte sedimentation rate (ESR), and differential blood count were analysed in apparently healthy parents (n=26) of homozygous children with familial Mediterranean fever (FMF)...
November 2015: Clinical and Experimental Rheumatology
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