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Saud Alanazi, Maryam Alnoman, Saeed Banawas, Ryoichi Saito, Mahfuzur R Sarker
C. perfringens type A is the causative agent of C. perfringens type A food poisoning (FP) and non-food-borne (NFB) human gastrointestinal diseases. Due to its ability to form highly heat-resistant spores, it is of great interest to develop strategies alternative to thermal processing to inactivate C. perfrinegens. Thus, in this study we evaluated the inhibitory effects of essential oil constituents (EOCs) (cinnamaldehyde, eugenol, allyl isothiocyanate (AITC), and carvacrol) against germination, outgrowth and vegetative growth of spores of C...
August 2018: Food Microbiology
Mariano S Pedano, Xin Li, Shuchen Li, Zeyi Sun, Stevan M Cokic, Eveline Putzeys, Kumiko Yoshihara, Yashuhiro Yoshida, Zhi Chen, Kirsten Van Landuyt, Bart Van Meerbeek
OBJECTIVES: To evaluate the effect of the eluates from 3 freshly-mixed and setting hydraulic calcium-silicate cements (hCSCs) on human dental pulp cells (HDPCs) and to examine the effect of a newly developed hCSC containing phosphopullulan (PPL) on HDPCs. METHODS: Human dental pulp cells, previously characterized as mesenchymal stem cells, were used. To collect the eluates, disks occupying the whole surface of a 12-well plate were prepared using an experimental hCSC containing phosphopullulan (GC), Nex-Cem MTA (GC), Biodentine (Septodont) or a zinc-oxide (ZnO) eugenol cement (material-related negative control)...
March 7, 2018: Dental Materials: Official Publication of the Academy of Dental Materials
Jason C Marvin, Silvia I Gallegos, Shaida Parsaei, Danieli C Rodrigues
PURPOSE: To evaluate the biocompatibility of five dental cement compositions after directly exposing human gingival fibroblast (HGF) and MC3T3-E1 preosteoblast cells to cement alone and cement applied on commercially pure titanium (cpTi) specimens. MATERIALS AND METHODS: Nanostructurally integrated bioceramic (NIB), resin (R), resin-modified glass ionomer (RMGIC), zinc oxide eugenol (ZOE), and zinc phosphate (ZP) compositions were prepared according to the respective manufacturer's instructions...
March 9, 2018: Journal of Prosthodontics: Official Journal of the American College of Prosthodontists
N Hussain, H Jabbar, M Hayati, J Wu, T P Hyde
OBJECTIVES: The 3 objectives are to assess current preferences for impressions for complete dentures, audit practice and compare practice to current UK teaching. METHODS: Three surveys where undertaken; a survey of GDPs preferences, an audit of practice and a survey of teaching in UK dental schools. RESULTS: UK Universities advocate border moulded custom trays. In stated preferences, 99% of practitioners used custom trays for private practice; 67% for NHS work...
March 8, 2018: European Journal of Prosthodontics and Restorative Dentistry
P M Rolim, G P Fidelis, C E A Padilha, E S Santos, H A O Rocha, G R Macedo
Melon (Cucumis melo L.) has high economic value and in recent years, its production has increased; however, part of the fruit is wasted. Usually, inedible parts such as peel and seeds are discarded during processing and consumption. Extracts of melon residues were prepared and their phenolic compounds, antioxidants and antiproliferative activities were evaluated. Total phenolic compounds were found in hydroethanolic, hydromethanolic, and aqueous extracts, especially for melon peel (1.016 mg gallic acid equivalent/100 g)...
March 1, 2018: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
Habib Mosbah, Hassiba Chahdoura, Jannet Kammoun, Malek Besbes Hlila, Hanen Louati, Saoussen Hammami, Guido Flamini, Lotfi Achour, Boulbaba Selmi
BACKGROUND: α-glucosidase is a therapeutic target for diabetes mellitus (DM) and α-glucosidase inhibitors play a vital role in the treatments for the disease. Furthermore, xanthine oxidase (XO) is a key enzyme that catalyzes hypoxanthine and xanthine to uric acid which at high levels can lead to hyperuricemia which is an important cause of gout. Pancreatic lipase (PL) secreted into the duodenum plays a key role in the digestion and absorption of fats. For its importance in lipid digestion, PL represents an attractive target for obesity prevention...
March 5, 2018: BMC Complementary and Alternative Medicine
Sina Safari, Fereshteh Hosseini Ghavam, Parviz Amini, Kaveh Yaghmaei
PURPOSE: The aim of this study was to evaluate the effects of abutment diameter, cement type, and re-cementation on the retention of implant-supported CAD/CAM metal copings over short abutments. MATERIALS AND METHODS: Sixty abutments with two different diameters, the height of which was reduced to 3 mm, were vertically mounted in acrylic resin blocks with matching implant analogues. The specimens were divided into 2 diameter groups: 4.5 mm and 5.5 mm (n=30). For each abutment a CAD/CAM metal coping was manufactured, with an occlusal loop...
February 2018: Journal of Advanced Prosthodontics
Atiqur Rahman, Mahmudur Rahman, Ibrahim Demirtas
In traditional system of medicine, leaves and stem bark of Euphorbia tithymaloides L. have been used for the treatment of asthma, persistent coughing, laryngitis, skin diseases and mouth ulcers. Some studies have reported the anti-inflammatory and antimicrobial activities of phytochemicals from leaf; however, the analysis of essential oil and its antioxidant property is still unexplored. This study evaluates the in vitro antioxidant potential of the essential oil and organic extracts from aerial parts of Euphorbia tithymaloides L...
February 28, 2018: Anti-cancer Agents in Medicinal Chemistry
Koroush Semnani, Masoomeh Shams-Ghahfarokhi, Mehran Afrashi, Aref Fakhrali, Dariush Semnani
Eugenol, as the major phenolic component of clove essential oil due to its desired properties in medical field, was loaded into polyacrylonitrile (PAN) nanofibers with various percentages. Our main purpose in this study was to determine the in vitro antifungal activity of eugenol loaded on PAN nanofibers against Candida albicans as the most common causative agent for candidiasis. Also, the surface morphology and the mechanical properties of nanofibers were studied by scanning electron microscope (SEM) and a tensile tester, respectively...
February 26, 2018: Current Drug Delivery
Hari Prasad Devkota, Bibek Adhikari, Takashi Watanabe, Shoji Yahara
Different plant parts of Ligusticopsis wallichiana (family: Apiaceae) are widely used as traditional medicines. Although many volatile constituents are already identified from the leaves of L. wallichiana , there is no detailed report on the nonvolatile constituents. In the present study, we aimed to isolate and identify the major chemical constituents from the leaves. Bhutkesoside A ( 1 ), falcarindiol ( 2 ), ferulic acid ( 3 ), cnidioside A ( 4 ), quercetin 3- O - β -D-glucopyranoside ( 5 ), rutin ( 6 ), 4'- O -methylquercetin 3- O - β -D-glucopyranoside ( 7 ), scopoletin ( 8 ), umbelliferone ( 9 ), eugenol 4- O - β -D-glucopyranoside ( 10 ) and pumilaside A ( 11 ) were isolated from the 70% MeOH extract...
2018: Journal of Analytical Methods in Chemistry
Tae-Kyun Hong, Haribalan Perumalsamy, Kyoung-Hwa Jang, Eun-Shik Na, Young-Joon Ahn
Bradysia procera is a serious insect pest of Panax ginseng plants. This study was conducted to determine the toxicity and mechanism of action of three phenylpropanoids, three terpenoids, and a ketone from Syzygium aromaticum bud methanol extract and hydrodistillate against third-instar larvae and eggs of B. procera. In a filter-paper mortality bioassay, methyl salicylate (LC50 , 5.26μg/cm2 ) was the most toxic compound, followed by 2-nonanone, eugenol, and eugenyl acetate (8.77-15.40μg/cm2 ). These compounds were significantly less toxic than either thiamethoxam, clothianidin, or cypermethrin...
February 2018: Pesticide Biochemistry and Physiology
Ameena Ali, Chien Hwa Chong, Siau Hui Mah, Luqman Chuah Abdullah, Thomas Shean Yaw Choong, Bee Lin Chua
The phenolic constituents in Piper betle are well known for their antioxidant potential; however, current literature has very little information on their stability under the influence of storage factors. Present study evaluated the stability of total phenolic content (TPC) and antioxidant activity together with individual phenolic constituents (hydroxychavicol, eugenol, isoeugenol and allylpyrocatechol 3,4-diacetate) present in dried Piper betle 's extract under different storage temperature of 5 and 25 °C with and without light for a period of six months...
February 23, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Ankita Kakar, Arundeep Kaur Lamba, Shruti Tandon, Farrukh Faraz, Abdul Ahad
Aim: The aim was to compare the gingival tissue response following placement of a light cure dressing (Barricaid® ) and a non-eugenol periodontal dressing (Coe-Pak™ ) after periodontal flap procedure. This was carried out by evaluating plaque deposition underneath both the dressings, healing response and the patient preference for each. Materials and Methods: A total of 12 patients with chronic generalized periodontitis requiring surgery in at least two different quadrants were enrolled for this split-mouth study...
January 2018: Journal of Natural Science, Biology, and Medicine
Giordana Feriotto, Nicola Marchetti, Valentina Costa, Piera Torricelli, Simone Beninati, Federico Tagliati, Carlo Mischiati
Re-expression of fetal hemoglobin (HbF) was proposed as a possible therapeutic strategy for β-haemoglobinopathies. Although several inducers of HbF were tested in clinical trials, only hydroxyurea (HU) received FDA approval. Despite it produced adequate HbF levels only in half of HU-treated SCD patients, and was ineffective at all in β-thalassemia patients, beneficial effects of this approach suggested to continue in this direction identifying further molecules capable of inducing HbF. We tested the potential of essential oil isolated from Ocimum basilicum L...
February 13, 2018: Fitoterapia
Ali Taheri Mirghaed, Mahyar Yasari, Seyed Saeed Mirzargar, Seyyed Morteza Hoseini
The aim of the present study was to investigate anesthetic efficacy of myrcene in rainbow trout (Oncorhynchus mykiss) along with the fish biochemical response to anesthesia in comparison with eugenol. In the first experiment, 240 fish were stocked in 12 tanks and acclimatized to experimental conditions for 2 weeks. Then, the fish of each tank were subjected to one concentration of either eugenol (12, 20, 30, 50, 80, and 130 μL/L) or myrcene (100, 150, 200, 300, 400, and 500 μL/L) concentrations. Induction time of and recovery time from anesthesia were recorded for each fish separately...
February 14, 2018: Fish Physiology and Biochemistry
Fong-Chin Huang, Ashok Giri, Melina Daniilidis, Guangxin Sun, Katja Härtl, Thomas Hoffmann, Wilfried Schwab
Glycosylation mediated by uridine diphosphate-dependent glycosyltransferase (UGT) is one of the most common reactions for the biosynthesis of small molecule glycosides. As glycosides have various biological roles we characterized UGTs from grapevine (Vitis vinifera). In silico analysis of VvUGTs that were highly expressed in leaves identified UGT92G6 which showed sequence similarity to both, monosaccharide and disaccharide glucoside forming transferases. The recombinant UGT92G6 glucosylated phenolics, among them caffeic acid, carvacrol, eugenol, and raspberry ketone, and also accepted geranyl glucoside and citronellyl glucoside...
February 10, 2018: Plant & Cell Physiology
Yi-Ming Wang, Ling-Cong Kong, Jie Liu, Hong-Xia Ma
Background: Bacterial infections have become more challenging to treat due to the emergence of multidrug-resistant pathogenic bacteria. Combined antibiotics prove to be a relatively effective method to control such resistant strains. This study aim to investigate synergistic activity of eugenol combined with colistin against a collection of clinical isolated Escherichia coli (E.coli) strains, and to evaluate potential interaction. Methods: Antimicrobial susceptibility, minimum inhibitory concentration (MIC) and fractional inhibitory concentration index (FICI) of the bacteria were determined by disk diffusion assay, broth microdilution method and checkerboard assay, respectively...
2018: Antimicrobial Resistance and Infection Control
Róbson Ricardo Teixeira, Poliana Aparecida Rodrigues Gazolla, Adalberto Manoel da Silva, Maria Paula Gonçalves Borsodi, Bartira Rossi Bergmann, Rafaela Salgado Ferreira, Boniek Gontijo Vaz, Géssica Adriana Vasconcelos, Wallace Pacienza Lima
In this paper, it is described the synthesis and the evaluation of the leishmanicidal activity of twenty-six eugenol derivatives bearing 1,2,3-triazole functionalities. The evaluation of the compounds on promastigotes of Leishmania amazonensis (WHOM/BR/75/Josefa) showed that eugenol derivatives present leishmanicidal activities with varying degrees of effectiveness. The most active compound, namely 4-(3-(4-allyl-2-methoxyphenoxy)propyl)-1-(4-methylbenzyl)-1H-1,2,3-triazole (7k) (IC50 = 7.4 ± 0.8 μmol L-1), also targeted Leishmania parasites inside peritoneal macrophages (IC50 = 1...
February 3, 2018: European Journal of Medicinal Chemistry
Jie Liu, Zhihong Wei, Haijun Jiao, Ralf Jackstell, Matthias Beller
Green Friedel-Crafts acylation reactions belong to the most desired transformations in organic chemistry. The resulting ketones constitute important intermediates, building blocks, and functional molecules in organic synthesis as well as for the chemical industry. Over the past 60 years, advances in this topic have focused on how to make this reaction more economically and environmentally friendly by using green acylating conditions, such as stoichiometric acylations and catalytic homogeneous and heterogeneous acylations...
January 24, 2018: ACS Central Science
Evan C Palmer-Young, Austin C Calhoun, Anastasiya Mirzayeva, Ben M Sadd
Ecological and evolutionary pressures on hosts and parasites jointly determine infection success. In pollinators, parasite exposure to floral phytochemicals may influence between-host transmission and within-host replication. In the bumble bee parasite Crithidia bombi, strains vary in phytochemical resistance, and resistance increases under in vitro selection, implying that resistance/infectivity trade-offs could maintain intraspecific variation in resistance. We assessed costs and benefits of in vitro selection for resistance to the floral phytochemical eugenol on C...
February 1, 2018: Scientific Reports
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