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Eugenol

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https://www.readbyqxmd.com/read/28541424/a-new-in-vitro-bioassay-system-for-the-discovery-and-quantitative-evaluation-of-mosquito-repellents
#1
Abbas Ali, Charles L Cantrell, Ikhlas A Khan
Mosquitoes vector many pathogens that cause human diseases. Repellents play a significant role in reducing the risk of these diseases by preventing mosquito bites. In this paper, we are reporting an Ali and Khan (A & K), large cage in vitro bioassay system that can effectively be used to measure repellency of compounds against mosquitoes. The system uses temperature as a landing and feeding stimulus, and collagen as a feeding substrate. The minimum effective dose (MED) of DEET (N, N-diethyl-meta-toluamide; 19...
May 24, 2017: Journal of Medical Entomology
https://www.readbyqxmd.com/read/28540643/improvement-of-fermented-fish-flour-quality-using-essential-oil-extracted-from-fresh-leaves-of-pimenta-racemosa-mill-j-w-moore
#2
Euloge S Adjou, René G Dègnon, Edwige Dahouenon-Ahoussi, Mohamed M Soumanou, Dominique C K Sohounhloue
The aim of this study was to evaluate the efficacy of the essential oil extracted from fresh leaves of Pimenta racemosa in the improvement of fermented fish flour producing technology. Essential oil of Pimenta racemosa was extracted by hydrodistillation and its chemical composition was determined by GC and GC/MS. Different types of fermented fish flours from Lesser African Threadfin (Galeoides decadactylus) were produced by the modification of the traditional processing technology and the introduction of a step of essential oil adjunction during the process...
May 24, 2017: Natural Products and Bioprospecting
https://www.readbyqxmd.com/read/28530570/enhanced-antimicrobial-activity-of-essential-oil-components-immobilized-on-silica-particles
#3
María Ruiz-Rico, Édgar Pérez-Esteve, Andrea Bernardos, Félix Sancenón, Ramón Martínez-Máñez, María D Marcos, José M Barat
The antimicrobial activity of essential oils components (EOCs) is well-known. However, their high volatility and powerful aroma limit their application in the formulation of a wide range of food products. In this context, the antimicrobial activity of carvacrol, eugenol, thymol and vanillin grafted onto the surface of three silica supports with different morphologies, textural properties and chemical reactivities (fumed silica, amorphous silica and MCM-41) was evaluated herein. Materials characterization revealed a good immobilization yield and all the devices showed a micro-scale particle size...
October 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28529778/crystal-structure-of-the-diglycidyl-ether-of-eugenol
#4
Jordan Vigier, Camille François, Sylvie Pourchet, Gilles Boni, Laurent Plasseraud, Vincent Placet, Stéphane Fontaine, Hélène Cattey
The diep-oxy monomer, C13H16O4 {DGE-Eu; systematic name: 2-[3-meth-oxy-4-(oxiran-2-ylmeth-oxy)benz-yl]oxirane}, was synthesized from eugenol by a three-step reaction. It consists of a 1,2,4-tris-ubstituted benzene ring substituted by diglycidyl ether, a meth-oxy group and a methyl-oxirane group. The three-membered oxirane rings are inclined to the benzene ring by 61.0 (3) and 27.9 (3)°. The methyl-ene C atom of one of the two terminal epoxide rings is positionally disordered [refined occupancy ratio = 0...
May 1, 2017: Acta Crystallographica. Section E, Crystallographic Communications
https://www.readbyqxmd.com/read/28525889/eugenol-alleviated-breast-precancerous-lesions-through-her2-pi3k-akt-pathway-induced-cell-apoptosis-and-s-phase-arrest
#5
Min Ma, Yi Ma, Gui-Juan Zhang, Rui Liao, Xue-Feng Jiang, Xian-Xin Yan, Feng-Jie Bie, Xiao-Bo Li, Yan-Hong Lv
Eugenol can be separated from the oil extract of clove bud, and has many pharmacological functions such as anticancer and transdermal absorption. HER2/PI3K-AKT is a key signaling pathway in the development of breast cancer. In this study, 80 μM eugenol could significantly inhibit the proliferation of HER-2 positive MCF-10AT cells and the inhibition rate was up to 32.8%, but had no obvious inhibitory effect on MCF-7 and MCF-10A cells with HER2 weak expression. Eugenol also significantly induced human breast precancerous lesion MCF-10AT cell apoptosis and cell cycle S-phase arrest, but the biological effects nearly disappeared after HER2 over-expression through transfecting pcDNA3...
May 5, 2017: Oncotarget
https://www.readbyqxmd.com/read/28524111/synthesis-and-pharmacological-properties-of-novel-esters-based-on-monoterpenoids-and-glycine
#6
Mariia Nesterkina, Iryna Kravchenko
Esters based on mono- and bicyclic terpenoids with glycine have been synthesized via Steglich esterification and characterized by ¹H-NMR, IR, and mass spectral studies. Their analgesic and anti-inflammatory activities were investigated after transdermal delivery on models of formalin, capsaicin, and AITC-induced pain, respectively. Glycine esters of menthol and borneol exhibited higher antinociceptive action, whereas eugenol derivative significantly suppressed the development of the inflammatory process. The mechanism of competitive binding between terpenoid esters and TRPA1/TRPV1 agonists was proposed explaining significant analgesic effect of synthesized derivatives...
May 18, 2017: Pharmaceuticals
https://www.readbyqxmd.com/read/28521511/effects-of-adaptation-to-carvacrol-on-staphylococcus-aureus-in-the-planktonic-and-biofilm-phases
#7
Antonia Nostro, Andreana Marino, Giovanna Ginestra, Luigina Cellini, Mara Di Giulio, Giuseppe Bisignano
The effect of exposure to sub-minimum inhibitory concentrations of carvacrol, for either 3-10 days, on direct (carvacrol) or cross-protection (cinnamaldehyde, eugenol, antibiotics) and the influence on planktonic and biofilm growth of four Staphylococcus aureus strains were reported. The sequential exposure to carvacrol resulted in a direct protection that was more evident in two of the four strains after 10 days. No significant cross-protection against cinnamaldehyde, eugenol and antibiotics was detected...
May 18, 2017: Biofouling
https://www.readbyqxmd.com/read/28518187/in-vitro-shock-absorption-tests-on-implant-supported-crowns-influence-of-crown-materials-and-luting-agents
#8
Martin Rosentritt, Sibylle Schneider-Feyrer, Michael Behr, Verena Preis
PURPOSE: To investigate the force absorption capacity of implant-supported crowns made of different restorative materials and connected to abutments with different luting agents. MATERIALS AND METHODS: Molar crowns were milled of different computer-aided design/computer-aided manufacture materials (n = 8 crowns per material): polymethyl methacrylate, polyether ether ketone, composite, lithium disilicate, titanium, and zirconia. Crowns were mounted on titanium implant replicas using different luting agents: uncemented, temporarily cemented (zinc oxide-eugenol cement), conventionally cemented (zinc oxide phosphate cement), and adhesively bonded...
May 18, 2017: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/28512490/in-vitro-cytotoxicity-of-a-new-nano-root-canal-sealer-on-human-gingival-fibroblasts
#9
Maryam Javidi, Parisa Dastmalchi, Mina Zarei, Maryam Shayani Rad, Ahmad Ghorbani
INTRODUCTION: The aim of this in vitro study was to evaluate the cytotoxicity of a new nano zinc-oxide eugenol (NZOE) sealer on human gingival fibroblasts (HGFs) compared with Pulpdent (micro-sized ZOE sealer) and AH-26 (resin-based sealer). METHODS AND MATERIALS: The Pulpdent, AH-26, and NZOE sealers were prepared and exposed to cell culture media immediately after setting, and 24 h and one week after setting. Then, the primary cultured HGFs were incubated for 24 h with different dilutions (1:1 to 1:32) of each sealer extract...
2017: Iranian Endodontic Journal
https://www.readbyqxmd.com/read/28497968/chemoenzymatic-synthesis-and-%C3%AE-glucosidase-inhibitory-activity-of-dimeric-neolignans-inspired-by-magnolol
#10
Luana Pulvirenti, Vera Muccilli, Nunzio Cardullo, Carmela Spatafora, Corrado Tringali
A chemoenzymatic synthesis of a small library of dimeric neolignans inspired by magnolol (1) is reported. The 2-iodoxybenzoic acid (IBX)-mediated regioselective ortho-hydroxylation of magnolol is described, affording the bisphenols 6 and 7. Further magnolol analogues (12, 13, 15-17, 19-23) were obtained from eugenol (3), tyrosol (4), and homovanillic alcohol (5), through horseradish peroxidase (HRP)-mediated oxidative coupling and regioselective ortho-hydroxylation or ortho-demethylation in the presence of IBX, followed by reductive treatment with Na2S2O4...
May 12, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/28494415/studies-on-curative-efficacy-of-monoterpene-eugenol-on-anti-leukemic-drug-arsenic-trioxide-induced-cardiotoxicity
#11
Prakash Binu, Nellikunnath Priya, Surendran Abhilash, Radhakrishnan Chandraprabha Vineetha, Raveendran Harikumaran Nair
BACKGROUND: Arsenic trioxide (As2O3) is emerging as a frontline agent for the treatment of acute promyelocytic leukemia (APL) but the therapeutic application is limited by its toxicity. QT prolongation, torsades de pointes and sudden cardiac death have been implicated in the As2O3 therapy. So eugenol is a monoterpene compound is well known for its antioxidant properties and protective effect on the cardiovascular system. OBJECTIVE: In this study, the cardioprotective effect of eugenol on cardiac electrical conductivity, tissue electrolytes, myocardial markers, antioxidant system, lipid peroxidation and nitric oxide production was investigated in male Wistar rats treated with arsenic trioxide...
May 7, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28492807/biochemical-parameters-of-silver-catfish-rhamdia-quelen-after-transport-with-eugenol-or-essential-oil-of-lippia-alba-added-to-the-water
#12
J Salbego, C Toni, A G Becker, C C Zeppenfeld, C C Menezes, V L Loro, B M Heinzmann, B Baldisserotto
The transport of live fish is a routine practice in aquaculture and constitutes a considerable source of stress to the animals. The addition of anesthetic to the water used for fish transport can prevent or mitigate the deleterious effects of transport stress. This study investigated the effects of the addition of eugenol (EUG) (1.5 or 3.0 µL L-1) and essential oil of Lippia alba (EOL) (10 or 20 µL L-1) on metabolic parameters (glycogen, lactate and total protein levels) in liver and muscle, acetylcholinesterase activity (AChE) in muscle and brain, and the levels of protein carbonyl (PC), thiobarbituric acid reactive substances (TBARS) and nonprotein thiol groups (NPSH) and activity of glutathione-S-transferase in the liver of silver catfish (Rhamdia quelen; Quoy and Gaimard, 1824) transported for four hours in plastic bags (loading density of 169...
May 4, 2017: Brazilian Journal of Biology, Revista Brasleira de Biologia
https://www.readbyqxmd.com/read/28487962/embryotoxicity-estimation-of-commonly-used-compounds-with-embryonic-stem-cell-test
#13
Hui Liu, Caiping Ren, Weidong Liu, Xingjun Jiang, Lei Wang, Bin Zhu, Wei Jia, Jianxing Lin, Jun Tan, Xiuying Liu
The embryonic stem cell test (EST), an alternative model to animal studies, is a reliable and scientifically validated in vitro system for testing embryotoxicity. In contrast to most in vivo animal tests, two permanent cell lines, murine fibroblasts (BALB/c‑3T3 cells) and murine embryonic stem cells (mES‑D3 cells), are used in EST instead of animals in standard tests of toxicity. The embryotoxic potential of compounds (non, weak or strong embryotoxicity) may be obtained with a biostatistics‑based prediction model and calculated from three different experimental endpoint values: The potency to inhibit growth of i) BALB/c‑3T3 cells and ii) mES‑D3 cells (IC503T3 and IC50ES) as presented using a cell cytotoxicity assay, and iii) the potency to inhibit differentiation of mES‑D3 cells into contracting cardiomyocytes (ID50 D3) as demonstrated in a mES‑D3 cell differentiation assay...
May 9, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28487683/trans-cinnamaldehyde-carvacrol-and-eugenol-reduce-campylobacter-jejuni-colonization-factors-and-expression-of-virulence-genes-in-vitro
#14
Abhinav Upadhyay, Komala Arsi, Basanta R Wagle, Indu Upadhyaya, Sandip Shrestha, Ann M Donoghue, Dan J Donoghue
Campylobacter jejuni is a major foodborne pathogen that causes severe gastroenteritis in humans characterized by fever, diarrhea, and abdominal cramps. In the human gut, Campylobacter adheres and invades the intestinal epithelium followed by cytolethal distending toxin mediated cell death, and enteritis. Reducing the attachment and invasion of Campylobacter to intestinal epithelium and expression of its virulence factors such as motility and cytolethal distending toxin (CDT) production could potentially reduce infection in humans...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28479918/bovine-tooth-discoloration-induced-by-endodontic-filling-materials-for-primary-teeth
#15
Samantha Rodrigues Xavier, Katerine Jahnecke Pilownic, Andressa Heberle Gastmann, Mariana Silveira Echeverria, Ana Regina Romano, Fernanda Geraldo Pappen
Objective. This study evaluated the discoloration potential of endodontic materials used in primary teeth. Material and Methods. Dentine-enamel blocks were prepared from 75 bovine teeth, assorted in five experimental groups (n = 15). The tested materials included an MTA-based material; zinc oxide and eugenol cement (ZOE); Vitapex; and calcium hydroxide thickened with zinc oxide (Calen + ZO). The color measurements were performed using a spectrophotometer at the following intervals: prior to (T0) and after placement of the filling (T1) and after 1 week (T2), 1 month (T3), 3 months (T4), 6 months (T5), and 9 months (T6)...
2017: International Journal of Dentistry
https://www.readbyqxmd.com/read/28469824/traction-test-of-temporary-dental-cements
#16
Juan-Luis Román-Rodríguez, Diego Millan-Martínez, Antonio Fons-Font, Rubén Agustín-Panadero, Lucía Fernández-Estevan
BACKGROUND: Classic self-curing temporary cements obstruct the translucence of provisional restorations. New dual-cure esthetic temporary cements need investigation and comparison with classic cements to ensure that they are equally retentive and provide adequate translucence. The objective is to analyze by means of traction testing in a in vitro study the retention of five temporary cements. MATERIAL AND METHODS: Ten molars were prepared and ten provisional resin restorations were fabricated using CAD-CAM technology (n=10)...
April 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/28461773/activation-of-transient-receptor-potential-vanilloid-3-by-the-methanolic-extract-of-schisandra-chinensis-fruit-and-its-chemical-constituent-%C3%AE-schisandrin
#17
Yuran Nam, Hyun Jong Kim, Young-Mi Kim, Young-Won Chin, Yung Kyu Kim, Hyo Sang Bae, Joo Hyun Nam, Woo Kyung Kim
Transient receptor potential vanilloid 3 (TRPV3) is a non-selective cation channel with modest permeability to calcium ions. It is involved in intracellular calcium signaling and is therefore important in processes such as thermal sensation, skin barrier formation, and wound healing. TRPV3 was initially proposed as a warm temperature sensor. It is activated by synthetic small-molecule chemicals and plant-derived natural compounds such as camphor and eugenol. Schisandra chinensis (Turcz.) Baill (SC) has diverse pharmacological properties including antiallergic, anti-inflammatory, and wound healing activities...
May 2017: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/28458297/influence-of-clove-oil-and-eugenol-on-muscle-contraction-of-silkworm-bombyx-mori
#18
Kantaporn Kheawfu, Surachai Pikulkaew, Hiroshi Hamamoto, Kazuhisa Sekimizu, Siriporn Okonogi
Clove oil is used in fish anesthesia and expected to have a mechanism via glutamic receptor. The present study explores the activities of clove oil and its major compound, eugenol, in comparison with L-glutamic acid on glutamic receptor of silkworm muscle and fish anesthesia. It was found that clove oil and eugenol had similar effects to L-glutamic acid on inhibition of silkworm muscle contraction after treated with D-glutamic acid and kainic acid. Anesthetic activity of the test samples was investigated in goldfish...
April 30, 2017: Drug Discoveries & Therapeutics
https://www.readbyqxmd.com/read/28450018/interaction-between-natural-antioxidants-derived-from-cinnamon-and-cocoa-in-binary-and-complex-mixtures
#19
Dimas Rahadian Aji Muhammad, Danar Praseptiangga, Davy Van de Walle, Koen Dewettinck
Cinnamon and cocoa are known to be valuable sources of bioactive phytochemicals, mainly the polyphenols. This paper investigates the potential antioxidant activity of cinnamon and cocoa extract and the interaction of their mixtures by various in vitro tests. Moreover, the combination effect of their constituents in a binary mixture was studied. Two representative active compounds of chocolate (epicatechin, catechin) were combined with seven of cinnamon (gallic acid, tannic acid, quercetin, sinapic acid, cinnamic acid, eugenol and cinnamaldehyde) in multilevel ratios...
September 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28449595/pharmaceutical-perspectives-of-spices-and-condiments-as-alternative-antimicrobial-remedy
#20
Savita P D'Souza, Suvarna V Chavannavar, B Kanchanashri, S B Niveditha
Medicinal values of spices and condiments are being revived by biologists through in vitro and in vivo trials providing evidence for its antimicrobial activities. The essential oils and extracts of spices like black pepper, cloves, cinnamon, and nutmeg contain active compounds like piperine, eugenol, cinnamaldehyde, and lignans. Similarly, condiments like coriander, black cumin, turmeric, garlic, and ginger are recognized for constituents like linalool, thymoquinones, curcumin, allicin, and geranial respectively...
January 1, 2017: Journal of Evidence-based Complementary & Alternative Medicine
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