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Archana Vimal, Anubhuti Jha, Awanish Kumar
Salmonella typhimurium is the causative agent of severe human infections and mortality throughout the world. Pacing advent of new resistance mechanisms in this microorganism exists, rendering treatment of infectious disease difficult. Ciprofloxacin is no longer considered the first choice of antimicrobial agent due to the emergence of resistance. Therefore, the need for scenario is to find out novel drug target and its potential inhibitor to fight against this pathogen. The present study was undertaken to find out a novel drug target and its inhibitor for improving the current therapeutic methods for treating Salmonella infections...
November 11, 2017: Microbial Pathogenesis
Rabih Darwiche, Ola El Atab, Stéphanie Cottier, Roger Schneiter
In their natural habitat, yeast cells are constantly challenged by changing environmental conditions and a fierce competition for limiting resources. To thrive under such conditions, cells need to adapt and divide quickly, and be able to neutralize the toxic compounds secreted by their neighbors. Proteins like the pathogen-related yeast, Pry proteins, which belong to the large CAP/SCP/TAPS superfamily, may have an important role in this function. CAP proteins are conserved from yeast to man and are characterized by a unique αβα sandwich fold...
November 10, 2017: FEBS Letters
Shipra Jaidka, Rani Somani, Deepti Jawa Singh, Tasneem Sheikh, Nidhi Chaudhary, Asiya Basheer
Background: Herbs have renewed importance in this modern era for their antimicrobial properties and fewer side effects. So a novel idea to use these herbs for pulpectomy; was implemented. There are chances of failure of pulpectomy due to inefficient removal of microbial load. Thus, for a successful endodontic treatment, obturating material with optimum antimicrobial properties is advocated in the present study. Aim: To compare and evaluate the antibacterial efficacy of zinc oxide eugenol, zinc oxide with tulsi extract and zinc oxide with aloe vera as obturating materials against E...
September 2017: Journal of Oral Biology and Craniofacial Research
Sergio A Rodriguez, O A Pinto, Axel Hollmann
Unravelling the chemical language of insects has been the subject of intense research in the field of chemical ecology for the past five decades. Insect communication is mainly based on chemosensation due to the small body size of insects, which limits their ability to produce or perceive auditory and visual signals, especially over large distances. Chemicals involved in insect communication are called semiochemicals. These volatiles and semivolatiles compounds allow to Insects to find a mate, besides the oviposition site in reproduction and food sources...
November 2, 2017: Colloids and Surfaces. B, Biointerfaces
Immacolata Anacarso, Carla Sabia, Simona de Niederhäusern, Ramona Iseppi, Carla Condò, Moreno Bondi, Patrizia Messi
Several species of the genus Acanthamoeba cause human diseases. Treatment of infections involves various problems, emphasising the need to develop alternative antiprotozoal agents. We studied the anti-amoebic activity of Essential Oils (EOs), derived from rosemary (Rosmarinus officinalis L.) and cloves (Syzygium aromaticum L. Merr. & Perry), against Acanthamoeba polyphaga strain. The amoebicidal activity of cloves and rosemary EOs was preliminary demonstrated by the morphology change (modifications in the cell shape, the presence of precipitates in the cytoplasm, autophagic vesicles, membrane blends) of the treated trophozoites...
November 8, 2017: Natural Product Research
Chi Nguyen Thi Thanh, Mai Truong Thi Cam, Thong Pham Van, Long Nguyen, My Nguyen Ha, Luc Van Meervelt
The synthesis of potassium (η(2)-4-allyl-2-methoxyphenol)trichloridoplatinate(II), K[PtCl3(C10H12O2)], (1), starting from Zeise's salt and Ocimum sanctum L. oil has been optimized. Starting from (1), three new platinum(II) complexes, namely (η(2)-4-allyl-2-methoxyphenol)chlorido(2-methylquinolin-8-olato-κ(2)N,O)platinum(II), (2), (η(2)-4-allyl-2-methoxyphenol)chlorido(5-nitroquinolin-8-olato-κ(2)N,O)platinum(II), (3), and (η(2)-4-allyl-2-methoxyphenol)chlorido(5,7-dichloroquinolin-8-olato-κ(2)N,O)platinum(II), [Pt(C9H4Cl2NO)Cl(C10H12O2)], (4), containing eugenol and a quinolin-8-ol derivative (R-OQ), have been synthesized and characterized by elemental analyses, MS, IR, (1)H NMR and NOESY spectra...
November 1, 2017: Acta Crystallographica. Section C, Structural Chemistry
Nilgoon Pasdar, Bahman Seraj, Mostafa Fatemi, Shirin Taravati
Background: This study was carried out to evaluate the effect of root canal filling on the bond strength of three intracanal posts in the primary incisors. Materials and Methods: Sixty primary incisors were prepared and then divided into two groups (n = 30). The first group canals obturated with zinc oxide eugenol (ZOE) and Group 2 canals obturated with Metapex. Further, the two group categories were divided into three subgroups (n = 10): (1) short composite post (SCP), (2) glass fiber posts (GFPs) cemented with flowable composite, and (3) GFP with glass ionomer cement (GFP + GIC)...
September 2017: Dental Research Journal
Fatin Myra Abd Manan, Nursyafreena Attan, Zainoha Zakaria, Aemi S Abdul Keyon, Roswanira Abdul Wahab
A biotechnological route via enzymatic esterification was proposed as an alternative way to synthesize the problematic anti-oxidant eugenyl benzoate. The new method overcomes the well-known drawbacks of the chemical route in favor of a more sustainable reaction process. The present work reports a Box-Behnken design (BBD) optimization process to synthesize eugenyl benzoate by esterification of eugenol and benzoic acid catalyzed by the chitosan-chitin nanowhiskers supported Rhizomucor miehei lipase (RML-CS/CNWs)...
January 2018: Enzyme and Microbial Technology
Changliang Jing, Jianyu Gou, Xiaobin Han, Qian Wu, Chengsheng Zhang
Phytophthora nicotianae causes serious black shank disease in tobacco. Syringa oblata essential oil and its main components were evaluated to develop an effective and environmentally friendly biocontrol agent. Eugenol, which exhibited the strongest activity, was intensively investigated in vitro and in vivo. The mycelial growth of P. nicotianae was inhibited by eugenol at a minimum inhibitory concentration of 200μgmL(-1), and inhibition occurred in a dose-dependent manner. Extracellular pH and extracellular conductivity results indicated that eugenol increased membrane permeability...
October 2017: Pesticide Biochemistry and Physiology
Brahmananda Dutta, Kanika S Dhull, Debasmita Das, P V Samir, Rajnish K Verma, Nipa Singh
Introduction: Bacteria and their products play a primary etiological role in the initiation and perpetuation of pulpoperiapical pathosis. Intracanal medication is important for endodontic success as it eliminates microorganisms that persist after chemomechanical preparation. Aim: To compare antimicrobial efficacy of calcium hydroxide powder, triple antibiotic paste, calcium hydroxide with 2% chlorhexidine solution, and triple antibiotic paste with 2% chlorhexidine solution...
July 2017: International Journal of Clinical Pediatric Dentistry
Yi Zhang, Yue Wang, Xiaojing Zhu, Ping Cao, Shaomin Wei, Yanhua Lu
The antibacterial effect and mechanism of eugenol from Syzygium aromaticum (L.) Merr. & L. M. Perry (clove) leaf essential oil (CLEO) against oral anaerobe Porphyromonas gingivalis were investigated. The results showed that eugenol, with content of 90.84% in CLEO, exhibited antibacterial activity against P. gingivalis at a concentration of 31.25 μM. Cell shrink and lysis caused by eugenol were observed with Scanning Electron Microscopy (SEM). The release of macromolecules and uptake of fluorescent dye indicated that the antibacterial activity was due to the ability of eugenol to permeabilize the cell membrane and destroy the integrity of plasmatic membrane irreversibly...
October 31, 2017: Microbial Pathogenesis
Jérôme Muchembled, Caroline Deweer, Karin Sahmer, Patrice Halama
The antifungal activity of seven essential oils (eucalyptus, clove, mint, oregano, savory, tea tree, and thyme) was studied on Venturia inaequalis, the fungus responsible for apple scab. The composition of the essential oils was checked by gas chromatography-mass spectrometry. Each essential oil had its main compound. Liquid tests were performed to calculate the IC50 of essential oils as well as their majority compounds. The tests were made on two strains with different sensitivities to tebuconazole: S755, the sensitive strain, and rs552, the strain with reduced sensitivity...
November 2, 2017: Environmental Science and Pollution Research International
Xiaoxian Chen, Xinggang Liu, Jie Zhong
BACKGROUND: To avoid untoward changes when primary teeth are replaced by permanent teeth, resorption of the material used in primary teeth root canal filling should occur at the same rate as root resorption. The Aim of this study was to compare the success rates of a mixed primary root canal filling (MPRCF, ingredients: zinc oxide-eugenol [ZOE], iodoform, calcium hydroxide) to those of ZOE and Vitapex in pulpectomised primary molars. METHODS: One hundred and sixty primary molars from 155 children (average age 5...
October 27, 2017: Head & Face Medicine
Syed S Islam, Ibtehaj Al-Sharif, Ahlam Sultan, Amer Al-Mazrou, Adnane Remmal, Abdelilah Aboussekhra
Triple-negative breast tumors are very aggressive and contain relatively high proportion of cancer stem cells, and resistant to chemotherapeutic drugs including cisplatin. To overcome these limitations, we combined eugenol, a natural polyphenolic molecule with cisplatin to normalize cisplatin mediated toxicity and potential drug resistance. Interestingly, the combination treatment provided significantly greater cytotoxic and pro-apoptotic effects as compared to treatment with eugenol or cisplatin alone on several triple-negative breast cancer cells both in vitro and in vivo...
October 26, 2017: Molecular Carcinogenesis
Chang Yang, Shou-Ying Du, Jie Bai, Peng-Yue Li, Ya-Hua Cui, Bing Yang
To establish a determination method for the contents of paeonol, eugenol and piperine in receptor liquid and to research the transdermal permeability of Huoxue Zhitong patch. The contents of paeonol, eugenol and piperine in receptor liquid were determined by high pressure liquid chromatography(HPLC); and the receptor liquid was optimized by taking accumulative amount penetrated within 24 hours, percutaneous permeation rate and skin irritation as indexes. In vitro Franz diffusion experiment was applied to assess the percutaneous penetration characteristics and regularity of Huoxue Zhitong patch...
April 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
Dandan Zhou, Zhuo Wang, Mengyu Li, Mengke Xing, Tingting Xian, Kang Tu
AIMS: This study aimed to investigate the antifungal mechanism of carvacrol and eugenol to inhibit Rhizopus stolonifer and the control of postharvest soft rot decay in peaches. METHODS AND RESULTS: For antifungal mechanism, effects of carvacrol and eugenol on the mycelium growth, leakages of cytoplasmic contents, mycelium morphology, cell membrane, and membrane composition of R. stolonifer was investigated. Carvacrol and eugenol both exhibited dose-depended antifungal activity against R...
October 17, 2017: Journal of Applied Microbiology
Soo Kyung Jun, Hae-Won Kim, Hae-Hyoung Lee, Jung-Hwan Lee
OBJECTIVE: Zinc oxide eugenol (ZOE) is widely used as a therapeutic dental restorative material. However, ZOE has poor mechanical properties and high cytotoxicity toward human dental pulp stem cells (hDPSCs) due to the release of Zn ions. In this study, zirconia-incorporated ZOE (ZZrOE) was developed to reduce the cytotoxicity and improve the mechanical properties of ZOE with sustained therapeutic effects on inflamed hDPSCs in terms of inflammatory gene expression levels compared with those of the original material...
October 13, 2017: Dental Materials: Official Publication of the Academy of Dental Materials
Mitra Askari, Anna Saffarpour, Jalal Purhashemi, Atena Beyki
STATEMENT OF THE PROBLEM: Researchers have long been in search of products to enhance healing and patient comfort postoperatively. PURPOSE: This study aimed to assess the efficacy of propolis extract in combination with Coe-Pak(TM) dressing for pain relief and wound healing after crown lengthening surgery. MATERIALS AND METHOD: This randomized clinical trial was performed on 36 patients who were randomly divided into two groups of Coe-Pak(TM) dressing with (trial group) and without (control group) propolis extract...
September 2017: Journal of Dentistry
Ephantus J Muturi, Jose L Ramirez, Kenneth M Doll, Michael J Bowman
Essential oils are potential alternatives to synthetic insecticides because they have low mammalian toxicity, degrade rapidly in the environment, and possess complex mixtures of bioactive constituents with multi-modal activity against the target insect populations. Twenty-one essential oils were initially screened for their toxicity against Aedes aegypti (L.) larvae and three out of the seven most toxic essential oils (Manuka, oregano, and clove bud essential oils) were examined for their chemical composition and combined toxicity against Ae...
November 7, 2017: Journal of Medical Entomology
Li Fangjun, Yang Zhijia
BACKGROUND: Eugenol, a natural compound available in Syzigium aromaticum (cloves), is exploited for various medicinal applications. Eugenol induces apoptosis and functions as an anti-cancer drug in several types of tumors. We investigated the tumor suppressive role and potential mechanisms of eugenol in human lung cancer cells. METHODS: Human embryonic lung fibroblast MRC-5 and lung cancer adenocarcinoma A549 cells were incubated with or without various concentrations of eugenol for 24 hours...
October 12, 2017: Thoracic Cancer
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