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https://www.readbyqxmd.com/read/27845521/adolescents-experience-of-parental-psychological-caregiving-and-neglect-construct-development
#1
Sharon L Christ, Yoon Young Kwak, Ting Lu
Psychological or emotional neglect is a recognized form of child maltreatment in the United States. However, neglect as a form of maltreatment and particularly psychological neglect as a subtype are understudied relative to other forms of maltreatment. One reason for this is that few measures of psychological (or emotional) neglect are available and there remains some uncertainty about how to define and measure it. In this article, we put forth a theoretical definition of psychological caregiving, including omission of care or psychological neglect of adolescents by their primary caregivers...
August 15, 2016: American Journal of Orthopsychiatry
https://www.readbyqxmd.com/read/27179815/impact-of-blandm-1-on-fitness-and-pathogenicity-of-escherichia-coli-and-klebsiella-pneumoniae
#2
Stephan Göttig, Sara Riedel-Christ, Ahmad Saleh, Volkhard A J Kempf, Axel Hamprecht
The objective of this study was to determine whether acquisition of New Delhi metallo-β-lactamase-1 (NDM-1) has an impact on the fitness and virulence of Escherichia coli and Klebsiella pneumoniae. Growth kinetics and the cost of fitness of NDM-1 plasmid carriage were assessed in isogenic E. coli J53 and K. pneumoniae PRZ in vitro by pairwise competition assays. The pathogenicity of NDM-1-expressing E. coli and K. pneumoniae strains and their isogenic controls was analysed in vivo using a Galleria mellonella infection model...
June 2016: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/26320705/working-with-cancer-health-and-employment-among-cancer-survivors
#3
Tainya C Clarke, Sharon L Christ, Hosanna Soler-Vila, David J Lee, Kristopher L Arheart, Guillermo Prado, Alberto Caban Martinez, Lora E Fleming
PURPOSE: Cancer affects a growing proportion of US workers. Factors contributing to whether they continue or return to work after cancer diagnosis include: age, physical and mental health, health insurance, education, and cancer site. The purpose of this study was to assess the complex relationships between health indicators and employment status for adult cancer survivors. METHODS: We analyzed pooled data from the 1997-2012 US National Health Interview Survey (NHIS)...
November 2015: Annals of Epidemiology
https://www.readbyqxmd.com/read/26242864/multicohort-analysis-of-the-maternal-age-effect-on-recombination
#4
Hilary C Martin, Ryan Christ, Julie G Hussin, Jared O'Connell, Scott Gordon, Hamdi Mbarek, Jouke-Jan Hottenga, Kerrie McAloney, Gonnecke Willemsen, Paolo Gasparini, Nicola Pirastu, Grant W Montgomery, Pau Navarro, Nicole Soranzo, Daniela Toniolo, Veronique Vitart, James F Wilson, Jonathan Marchini, Dorret I Boomsma, Nicholas G Martin, Peter Donnelly
Several studies have reported that the number of crossovers increases with maternal age in humans, but others have found the opposite. Resolving the true effect has implications for understanding the maternal age effect on aneuploidies. Here, we revisit this question in the largest sample to date using single nucleotide polymorphism (SNP)-chip data, comprising over 6,000 meioses from nine cohorts. We develop and fit a hierarchical model to allow for differences between cohorts and between mothers. We estimate that over 10 years, the expected number of maternal crossovers increases by 2...
August 5, 2015: Nature Communications
https://www.readbyqxmd.com/read/25905472/primary-cholecystectomy-is-feasible-in-elderly-patients-with-acute-cholecystitis
#5
COMPARATIVE STUDY
Peter C Ambe, Sebastian A Weber, Hildegard Christ, Dirk Wassenberg
BACKGROUND: While early cholecystectomy is generally accepted as the standard procedure for young and fit patients with acute cholecystitis, controversy exits on the management of elderly and severely sick patients. We postulated that primary cholecystectomy is feasible in this subgroup. The aim of this study was to compare the outcomes of young and fit patients to those of elderly patients undergoing surgery for acute cholecystitis. METHODS: The outcomes of elderly patients (≥70 years) undergoing surgery for acute cholecystitis in a primary care center in Germany were retrospectively compared to those of younger patients (<70 years)...
December 2015: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/25538792/cholecystectomy-for-acute-cholecystitis-how-time-critical-are-the-so-called-golden-72%C3%A2-hours-or-better-golden-24%C3%A2-hours-and-silver-25-72-hour-a-case-control-study
#6
Peter Ambe, Sebastian A Weber, Hildegard Christ, Dirk Wassenberg
INTRODUCTION: Early cholecystectomy within 72 hours has been shown to be superior to late or delayed cholecystectomy with regard to outcome and cost of treatment. Recently, immediate cholecystectomy within 24 hours of onset of symptom was proposed as standard procedure for the management of fit patients presenting with acute cholecystitis. We sort to find out if there are any differences in surgical outcomes between patients managed within 24 h and those managed 25-72 h following symptom begin for acute cholecystitis...
2014: World Journal of Emergency Surgery: WJES
https://www.readbyqxmd.com/read/25255074/pharmacokinetics-of-hydromorphone-after-intravenous-and-intramuscular-administration-in-male-rhesus-macaques-macaca-mulatta
#7
Kristi R Kelly, Bruno H Pypendop, Kari L Christe
This study reports the pharmacokinetics of hydromorphone after intravenous and intramuscular administration to rhesus macaques (Macaca mulatta). Hydromorphone (0.075 mg/kg) was administered intravenously as a bolus or intramuscularly on separate occasions to healthy, socially housed, socially reared, adult, intact male rhesus macaques (n = 4). Blood samples were collected prior to and until 10 h after administration. Serum hydromorphone concentrations were analyzed with liquid chromatography-mass spectrometry...
September 2014: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/24647802/isolated-insular-strokes-and-plasma-mr-proanp-levels-are-associated-with-newly-diagnosed-atrial-fibrillation-a-pilot-study
#8
Karl Frontzek, Felix Fluri, Jakob Siemerkus, Beat Müller, Achim Gass, Mirjam Christ-Crain, Mira Katan
INTRODUCTION: In this study, we assessed the relationship of insular strokes and plasma MR-proANP levels with newly diagnosed atrial fibrillation (NDAF). METHODS: This study is based on a prospective acute stroke cohort (http://www.clinicaltrials.gov, NCT00390962). Patient eligibility was dependent on the diagnosis of acute ischemic stroke, absence of previous stroke based on past medical history and MRI, no history of AF and congestive heart failure (cohort A) and, additionally, no stroke lesion size ≥ 20 mL (sub-cohort A*)...
2014: PloS One
https://www.readbyqxmd.com/read/23905732/actinomycetes-with-antimicrobial-activity-isolated-from-paper-wasp-hymenoptera-vespidae-polistinae-nests
#9
Anne A Madden, Andrew Grassetti, Jonathan-Andrew N Soriano, Philip T Starks
Actinomycetes-a group of antimicrobial producing bacteria-have been successfully cultured and characterized from the nest material of diverse arthropods. Some are symbionts that produce antimicrobial chemicals found to protect nest brood and resources from pathogenic microbes. Others have no known fitness relationship with their associated insects, but have been found to produce antimicrobials in vitro. Consequently, insect nest material is being investigated as a new source of novel antimicrobial producing actinomycetes, which could be harnessed for therapeutic potential...
August 2013: Environmental Entomology
https://www.readbyqxmd.com/read/23877944/procalcitonin-to-initiate-or-discontinue-antibiotics-in-acute-respiratory-tract-infections
#10
REVIEW
Philipp Schuetz, Beat Müller, Mirjam Christ-Crain, Daiana Stolz, Michael Tamm, Lila Bouadma, Charles E Luyt, Michel Wolff, Jean Chastre, Florence Tubach, Kristina B Kristoffersen, Olaf Burkhardt, Tobias Welte, Stefan Schroeder, Vandack Nobre, Long Wei, Neera Bhatnagar, Heiner C Bucher, Matthias Briel
BACKGROUND: Acute respiratory infections (ARIs) comprise a large and heterogeneous group of infections including bacterial, viral and other aetiologies. In recent years, procalcitonin - the prohormone of calcitonin - has emerged as a promising marker for the diagnosis of bacterial infections and for improving decisions about antibiotic therapy. Several randomised controlled trials (RCTs) have demonstrated the feasibility of using procalcitonin for starting and stopping antibiotics in different patient populations with acute respiratory infections and different settings ranging from primary care to emergency departments (EDs), hospital wards and intensive care units (ICUs)...
July 2013: Evidence-based Child Health: a Cochrane Review Journal
https://www.readbyqxmd.com/read/23648230/altitudinal-variation-in-haemosporidian-parasite-distribution-in-great-tit-populations
#11
Juan van Rooyen, Fabrice Lalubin, Olivier Glaizot, Philippe Christe
BACKGROUND: One of the major issues concerning disease ecology and conservation is knowledge of the factors that influence the distribution of parasites and consequently disease outbreaks. This study aimed to investigate avian haemosporidian composition and the distribution of these parasites in three altitudinally separated great tit (Parus major) populations in western Switzerland over a three-year period. The objectives were to determine the lineage diversity of parasites occuring across the study populations and to investigate whether altitudinal gradients govern the distribution of haemosporidian parasites by lineage...
2013: Parasites & Vectors
https://www.readbyqxmd.com/read/23366849/prosthesis-user-in-the-loop-a-user-specific-biomechanical-modeling-and-simulation-environment
#12
J Wojtusch, P Beckerle, O Christ, K Wolff, O von Stryk, S Rinderknecht, J Vogt
In this paper, a novel biomechanical modeling and simulation environment with an emphasis on user-specific customization is presented. A modular modeling approach for multi-body systems allows a flexible extension by specific biomechanical modeling elements and enables an efficient application in dynamic simulation and optimization problems. A functional distribution of model description and model parameter data in combination with standardized interfaces enables a simple and reliable replacement or modification of specific functional components...
2012: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/22972110/procalcitonin-to-initiate-or-discontinue-antibiotics-in-acute-respiratory-tract-infections
#13
REVIEW
Philipp Schuetz, Beat Müller, Mirjam Christ-Crain, Daiana Stolz, Michael Tamm, Lila Bouadma, Charles E Luyt, Michel Wolff, Jean Chastre, Florence Tubach, Kristina B Kristoffersen, Olaf Burkhardt, Tobias Welte, Stefan Schroeder, Vandack Nobre, Long Wei, Neera Bhatnagar, Heiner C Bucher, Matthias Briel
BACKGROUND: Acute respiratory infections (ARIs) comprise a large and heterogeneous group of infections including bacterial, viral and other aetiologies. In recent years, procalcitonin - the prohormone of calcitonin - has emerged as a promising marker for the diagnosis of bacterial infections and for improving decisions about antibiotic therapy. Several randomised controlled trials (RCTs) have demonstrated the feasibility of using procalcitonin for starting and stopping antibiotics in different patient populations with acute respiratory infections and different settings ranging from primary care to emergency departments (EDs), hospital wards and intensive care units (ICUs)...
September 12, 2012: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/21695560/the-subthreshold-autism-trait-questionnaire-satq-development-of-a-brief-self-report-measure-of-subthreshold-autism-traits
#14
Stephen M Kanne, Jennifer Wang, Shawn E Christ
The current study was motivated by a need for a self-report questionnaire that assesses a broad range of subthreshold autism traits, is brief and easily administered, and is relevant to the general population. An initial item pool was administered to 1,709 students. Structural validity analysis resulted in a 24-item questionnaire termed the Subthreshold Autism Trait Questionnaire (SATQ; Cronbach's alpha coefficient = .73, test-retest reliability = .79). An exploratory factor analysis suggested 5 factors...
May 2012: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/21682920/two-logistic-models-for-the-prediction-of-hypothyroidism-in-pregnancy
#15
Anthony U Mbah, Emmanuel C Ejim, Obinna D Onodugo, Francis O Ezugwu, Matthew I Eze, Peter O Nkwo, Winston C Ugbajah
BACKGROUND: The mounting evidence linking hypothyroidism during pregnancy with poor pregnancy outcome underscores the need for screening and, therefore, a search for more reliable and cheaper screening methods. METHODS: The study was conducted in two phases. The phase one study comprised of healthy women in different stages of pregnancy who attended routine antenatal clinic at St Theresa's Maternity Hospital, Enugu, Nigeria from September 6 to October 18 1994. In this study the variables compared between the hypothyroid and non-hypothyroid pregnant women were maternal age, the number of the pregnancy or gravidity, gestational age, social class, body weight, height, the clinically assessed size of the thyroid gland, serum free thyroxin (FT4) and serum thyrotrophin (TSH)...
2011: BMC Research Notes
https://www.readbyqxmd.com/read/21447747/regulation-of-whole-body-energy-homeostasis-with-growth-hormone-replacement-therapy-and-endurance-exercise
#16
Robert Oosterhof, Michael Ith, Roman Trepp, Emanuel Christ, Martin Flück
We hypothesized that network analysis is useful to expose coordination between whole body and myocellular levels of energy metabolism and can identify entities that underlie skeletal muscle's contribution to growth hormone-stimulated lipid handling and metabolic fitness. We assessed 112 metabolic parameters characterizing metabolic rate and substrate handling in tibialis anterior muscle and vascular compartment at rest, after a meal and exercise with growth hormone replacement therapy (GH-RT) of hypopituitary patients (n = 11)...
June 28, 2011: Physiological Genomics
https://www.readbyqxmd.com/read/21303029/near-threshold-equal-loudness-contours-for-harbor-seals-phoca-vitulina-derived-from-reaction-times-during-underwater-audiometry-a-preliminary-study
#17
Ronald A Kastelein, Paul J Wensveen, John M Terhune, Christ A F de Jong
Equal-loudness functions describe relationships between the frequencies of sounds and their perceived loudness. This pilot study investigated the possibility of deriving equal-loudness contours based on the assumption that sounds of equal perceived loudness elicit equal reaction times (RTs). During a psychoacoustic underwater hearing study, the responses of two young female harbor seals to tonal signals between 0.125 and 100 kHz were filmed. Frame-by-frame analysis was used to quantify RT (the time between the onset of the sound stimulus and the onset of movement of the seal away from the listening station)...
January 2011: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/21280746/large-heat-capacity-anomaly-near-the-consolute-point-of-the-binary-mixture-nitromethane-and-3-pentanol
#18
Patricia Losada-Pérez, Chandra Shekhar Pati Tripathi, Jan Leys, Christ Glorieux, Jan Thoen
The large critical anomaly in the isobaric heat capacity C(p,x)(T) of the binary mixture nitromethane + 3-pentanol is measured using high-resolution adiabatic scanning calorimetry. The unique features of this technique provided an alternative approach to the study of the critical behavior of C(p,x)(T), providing further C(p,x)(T) related quantities from which valuable information could be extracted. Our data are in full agreement with the predictions of the Modern Theory of Critical Phenomena; specifically, 3D-Ising model values for the critical exponent α and the universal amplitude ratio values of the leading critical amplitudes, as well as for the first correction-to-scaling ones, provide the optimum fits to represent the experimental data...
January 28, 2011: Journal of Chemical Physics
https://www.readbyqxmd.com/read/21230091/order-of-phase-transitions-and-tricriticality-in-mixtures-of-octyloxycyanobiphenyl-and-nonyloxycyanobiphenyl-liquid-crystals-a-high-resolution-study-by-adiabatic-scanning-calorimetry
#19
George Cordoyiannis, Chandra Shekhar Pati Tripathi, Christ Glorieux, Jan Thoen
A detailed study has been performed for mixtures of octyloxycyanobiphenyl (8OCB) and nonyloxycyanobiphenyl (9OCB) liquid crystals and nine of their mixtures by means of high-resolution adiabatic scanning calorimetry. The isotropic to nematic transitions are weakly first order with latent heat values in the range usually encountered for this transition in other liquid crystals. With the exception of pure 8OCB, for which only an upper limit of 1.8 J  kg(-1) for the latent heat could be established, finite latent heats have been obtained for the nematic to smectic-A transition of all the mixtures and of pure 9OCB...
September 2010: Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics
https://www.readbyqxmd.com/read/21227550/hiv-1-integrase-strand-transfer-inhibitors-design-synthesis-and-molecular-modeling-investigation
#20
Laura De Luca, Sara De Grazia, Stefania Ferro, Rosaria Gitto, Frauke Christ, Zeger Debyser, Alba Chimirri
This study is focused on a new series of benzylindole derivatives with various substituents at the benzene-fused ring, suggested by our 3D pharmacophore model developed for HIV-1 integrase inhibitors (INIs). All synthesized compounds proved to be active in the nanomolar range (6-35 nM) on the strand-transfer step (ST). In particular, derivative 4-[1-(4-fluorobenzyl)-5,7-dimethoxy-1H-indol-3-yl]-2-hydroxy-4-oxobut-2-enoic acid (8e), presenting the highest best-fit value on pharmacophore model, showed a potency comparable to that of clinical INSTIs GS 9137 (1) and MK-0518 (2)...
February 2011: European Journal of Medicinal Chemistry
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