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JOURNAL ARTICLE
Jack L Elsey, Eric L Miller, John A Christ, Linda M Abriola
While dozens of studies have attempted to estimate the Monod kinetic parameters of microbial reductive dechlorination, published values in the literature vary by 2-6 orders of magnitude. This lack of consensus can be attributed in part to limitations of both experimental design and parameter estimation techniques. To address these issues, Hamiltonian Monte Carlo was used to produce more than one million sets of realistic simulated microcosm data under a variety of experimental conditions. These data were then employed in model fitting experiments using a number of parameter estimation algorithms for determining Monod kinetic parameters...
February 20, 2024: Journal of Contaminant Hydrology
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JOURNAL ARTICLE
Caitlin K Frankish, Alexander M von Benda-Beckmann, Jonas Teilmann, Jakob Tougaard, Rune Dietz, Signe Sveegaard, Bas Binnerts, Christ A F de Jong, Jacob Nabe-Nielsen
Shipping is the most pervasive source of marine noise pollution globally, yet its impact on sensitive fauna remains unclear. We tracked 10 harbour porpoises for 5-10 days to determine exposure and behavioural reactions to modelled broadband noise (10 Hz-20 kHz, VHF-weighted) from individual ships monitored by AIS. Porpoises spent a third of their time experiencing ship noise above ambient, to which they regularly reacted by moving away during daytime and diving deeper during night. However, even ships >2 km away (noise levels of 93 ± 14 dB re 1 μPa2 ) caused animals to react 5-9 % of the time (∼18...
November 15, 2023: Marine Pollution Bulletin
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JOURNAL ARTICLE
Samuel Madariaga, Christ Devia, Antonello Penna, José I Egaña, Vanessa Lucero, Soledad Ramírez, Felipe Maldonado, Macarena Ganga, Nicolás Valls, Nicolás Villablanca, Tomás Stamm, Patrick L Purdon, Rodrigo Gutiérrez
BACKGROUND: Pharmacological tolerance is defined as a decrease in the effect of a drug over time, or the need to increase the dose to achieve the same effect. It has not been established whether repeated exposure to sevoflurane induces tolerance in children. METHODS: We conducted an observational study in children younger than 6 years of age scheduled for multiple radiotherapy sessions with sevoflurane anesthesia. To evaluate the development of sevoflurane tolerance, we analyzed changes in electroencephalographic spectral power at induction, across sessions...
November 13, 2023: Journal of Neurosurgical Anesthesiology
#4
EDITORIAL
Michael Christ
No abstract text is available yet for this article.
July 3, 2023: American Journal of Cardiology
#5
JOURNAL ARTICLE
I Wayan Christ Widhi Herman Tangkas, Vincent Sutresno Hadi Sujoto, Widi Astuti, Siti Nurul Aisyiyah Jenie, Ferian Anggara, Andhika Putera Utama, Himawan Tri Bayu Murti Petrus, Sutijan
Indonesia is one of the countries in the world that has been utilizing geothermal as a renewable energy source to generate electricity. Depending on the geological setting, geothermal brine possesses critical elements worthwhile to extract. One of the critical elements is lithium which is interesting in being processed as raw material for the battery industries. This study thoroughly presented titanium oxide material for lithium recovery from artificial geothermal brine and the effect of Li/Ti mole ratio, temperature, and solution pH...
2023: J Sustain Metall
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JOURNAL ARTICLE
Andreas Christ Sølvsten Jørgensen, Atiyo Ghosh, Marc Sturrock, Vahid Shahrezaei
The modelling of many real-world problems relies on computationally heavy simulations of randomly interacting individuals or agents. However, the values of the parameters that underlie the interactions between agents are typically poorly known, and hence they need to be inferred from macroscopic observations of the system. Since statistical inference rests on repeated simulations to sample the parameter space, the high computational expense of these simulations can become a stumbling block. In this paper, we compare two ways to mitigate this issue in a Bayesian setting through the use of machine learning methods: One approach is to construct lightweight surrogate models to substitute the simulations used in inference...
October 5, 2022: PLoS Computational Biology
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JOURNAL ARTICLE
Anupriya Aggarwal, Anouschka Akerman, Vanessa Milogiannakis, Mariana Ruiz Silva, Gregory Walker, Alberto Ospina Stella, Andrea Kindinger, Thomas Angelovich, Emily Waring, Supavadee Amatayakul-Chantler, Nathan Roth, Sandro Manni, Thomas Hauser, Thomas Barnes, Anna Condylios, Malinna Yeang, Maureen Wong, Tyra Jean, Charles S P Foster, Daniel Christ, Alexandra Carey Hoppe, Mee Ling Munier, David Darley, Melissa Churchill, Damien J Stark, Gail Matthews, William D Rawlinson, Anthony D Kelleher, Stuart G Turville
BACKGROUND: Genetically distinct viral variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been recorded since January 2020. The introduction of global vaccine programs has contributed to lower COVID-19 hospitalisation and mortality rates, particularly in developed countries. In late 2021, Omicron BA.1 emerged, with substantially altered genetic differences and clinical effects from other variants of concern. Shortly after dominating global spread in early 2022, BA...
September 18, 2022: EBioMedicine
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JOURNAL ARTICLE
Nenad Bartonicek, Romain Rouet, Joanna Warren, Claudia Loetsch, Gabriela Santos Rodriguez, Stacey Walters, Francis Lin, David Zahra, James Blackburn, Jillian M Hammond, Andre L M Reis, Ira W Deveson, Nathan Zammit, Mahdi Zeraati, Shane Grey, Daniel Christ, John S Mattick, Tatyana Chtanova, Robert Brink, Marcel E Dinger, Robert J Weatheritt, Jonathan Sprent, Cecile King
The notion that mobile units of nucleic acid known as transposable elements can operate as genomic controlling elements was put forward over six decades ago1,2 . However, it was not until the advancement of genomic sequencing technologies that the abundance and repertoire of transposable elements were revealed, and they are now known to constitute up to two-thirds of mammalian genomes3,4 . The presence of DNA regulatory regions including promoters, enhancers and transcription-factor-binding sites within transposable elements5-8 has led to the hypothesis that transposable elements have been co-opted to regulate mammalian gene expression and cell phenotype8-14 ...
August 2022: Nature
#9
JOURNAL ARTICLE
Romain Pigeault, Mathieu Chevalier, Camille-Sophie Cozzarolo, Molly Baur, Mathilde Arlettaz, Alice Cibois, André Keiser, Antoine Guisan, Philippe Christe, Olivier Glaizot
Understanding the drivers of infection risk helps us to detect the most at-risk species in a community and identify species whose intrinsic characteristics could act as potential reservoirs of pathogens. This knowledge is crucial if we are to predict the emergence and evolution of infectious diseases. To date, most studies have only focused on infections caused by a single parasite, leaving out co-infections. Yet, co-infections are of paramount importance in understanding the ecology and evolution of host-parasite interactions due to the wide range of effects they can have on host fitness and on the evolutionary trajectories of parasites...
June 24, 2022: International Journal for Parasitology
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JOURNAL ARTICLE
Antonela Bicvic, Natalie Scherrer, Juliane Schweizer, Felix Fluri, Mirjam Christ-Crain, Gian Marco De Marchis, Andreas R Luft, Mira Katan
Background: We investigated 92 blood biomarkers implicated in the pathophysiological pathways of ischemic injury, inflammation, hemostasis, and regulation of vascular resistance to predict post-stroke mortality. Aim: Based on the most promising markers, we aimed to create a novel Biomarker Panel Index (BPI) for risk stratification. Methods: In this prospective study, we measured 92 biomarkers in 320 stroke patients. The primary outcome measure was mortality within 90 days...
June 2022: European Stroke Journal
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JOURNAL ARTICLE
Anupriya Aggarwal, Alberto Ospina Stella, Gregory Walker, Anouschka Akerman, Camille Esneau, Vanessa Milogiannakis, Deborah L Burnett, Samantha McAllery, Mariana Ruiz Silva, Yonghui Lu, Charles S P Foster, Fabienne Brilot, Aleha Pillay, Sabastiaan Van Hal, Vennila Mathivanan, Christina Fichter, Andrea Kindinger, Alexandra Carey Hoppe, Mee Ling Munier, Supavadee Amatayakul-Chantler, Nathan Roth, Germano Coppola, Geoff P Symonds, Peter Schofield, Jennifer Jackson, Helen Lenthall, Jake Y Henry, Ohan Mazigi, Hans-Martin Jäck, Miles P Davenport, David R Darley, Gail V Matthews, David S Khoury, Deborah Cromer, Christopher C Goodnow, Daniel Christ, Roselle Robosa, Damien J Starck, Nathan W Bartlett, William D Rawlinson, Anthony D Kelleher, Stuart G Turville
Genetically distinct variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have emerged since the start of the COVID-19 pandemic. Over this period, we developed a rapid platform (R-20) for viral isolation and characterization using primary remnant diagnostic swabs. This, combined with quarantine testing and genomics surveillance, enabled the rapid isolation and characterization of all major SARS-CoV-2 variants circulating in Australia in 2021. Our platform facilitated viral variant isolation, rapid resolution of variant fitness using nasopharyngeal swabs and ranking of evasion of neutralizing antibodies...
June 2022: Nature Microbiology
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JOURNAL ARTICLE
Michal R Zieff, Michelle Hoogenhout, Emma Eastman, Björn U Christ, Alice Galvin, Victoria de Menil, Amina Abubakar, Charles R Newton, Elise Robinson, Kirsten A Donald
This study investigated the psychometric properties of the Swanson, Nolan, and Pelham ADHD Rating Scale (SNAP-IV) in a sample of South African children with neurodevelopmental disorders (n = 201), primarily Autism Spectrum Disorder and Intellectual Disability. We conducted a confirmatory factor analysis to inspect the two-factor structure of the SNAP-IV. We also calculated ordinal coefficient alpha to estimate internal consistency. Fit statistics for the two-factor model approached acceptable levels. The model fit improved slightly after removing an item related to spoken language...
April 22, 2022: Journal of Autism and Developmental Disorders
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JOURNAL ARTICLE
Mary Katherine Huffman, Sharon L Christ, Kenneth F Ferraro, David B Klenosky, Kristine Marceau, Steve Amireault
Objectives. The purpose of this study was to examine the psychometric properties of modified versions of the Behavioral Regulation in Exercise Questionnaire and Exercise Identity Scale for use with adults ages ≥55 years to measure regulatory styles and identity related to physical activity. Methods. Participants [ M age = 66.29 years ( SD = 7.06)] answered an online questionnaire twice across a four-week timescale. We assessed measurement invariance and convergent and divergent validity based on relations between regulatory styles, identity, and physical activity...
January 31, 2022: Journal of Aging and Health
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JOURNAL ARTICLE
Esther Wittermans, Philip A van der Zee, Hongchao Qi, Ewoudt M W van de Garde, Claudine A Blum, Mirjam Christ-Crain, Diederik Gommers, Jan C Grutters, G Paul Voorn, Willem Jan W Bos, Henrik Endeman
BACKGROUND: Latent class analysis (LCA) has identified subgroups with meaningful treatment implications in acute respiratory distress syndrome. We performed a secondary analysis of three studies to assess whether LCA can identify clinically distinct subgroups in community-acquired pneumonia (CAP) and whether the treatment effect of adjunctive corticosteroids differs between subgroups. METHODS: LCA was performed on baseline clinical and biomarker data from the Ovidius trial (n=304) and the Steroids in Pneumonia (STEP) trial (n=727), both randomised controlled trials investigating adjunctive corticosteroid treatment in CAP, and the observational TripleP cohort (n=201)...
January 2022: ERJ Open Research
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JOURNAL ARTICLE
Jack L Elsey, John A Christ, Linda M Abriola
Microcosm experiments to assess microbial reductive dechlorination of chlorinated aliphatic hydrocarbons typically experience 5-50% mass loss due to frequent sampling events and diffusion through septa. A literature review, however, reveals that models fit to such experiments for kinetic constant estimation have generally failed to account for experimental mass loss. To investigate possible resultant bias in best-fit parameters, a series of numerical experiments was conducted in which Monod kinetic models with and without mass loss were fit to more than 1300 synthetic data sets, generated using published microcosm data...
October 19, 2021: Environmental Science & Technology
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JOURNAL ARTICLE
Reshma Kassanjee, Leigh F Johnson, Elizabeth Zaniewski, Marie Ballif, Benedikt Christ, Constantin T Yiannoutsos, Patience Nyakato, Sophie Desmonde, Andrew Edmonds, Tavitiya Sudjaritruk, Jorge Pinto, Rachel Vreeman, Désiré Lucien Dahourou, Christelle Twizere, Azar Kariminia, James G Carlucci, Charles Kasozi, Mary-Ann Davies
INTRODUCTION: The Joint United Nations Programme on HIV/AIDS (UNAIDS) projections of paediatric HIV prevalence and deaths rely on the International epidemiology Databases to Evaluate AIDS (IeDEA) consortium for mortality estimates among children living with HIV (CHIV) receiving antiretroviral therapy (ART). Previous estimates, based on data through 2014, may no longer be accurate due to expanded paediatric HIV care and treatment eligibility, and the possibility of unreported deaths in CHIV considered lost to follow-up (LTFU)...
September 2021: Journal of the International AIDS Society
#17
JOURNAL ARTICLE
Pengfei Zhang, Marco Gandolfi, Francesco Banfi, Christ Glorieux, Liwang Liu
This work reports results on the simultaneous spectroscopy of the specific heat and thermal expansivity of glycerol by making use of a wideband time-resolved thermal lens (TL) technique. An analytical model is presented which describes TL transients in a relaxing system subjected to impulsive laser heating. Experimentally, a set of TL waveforms, from 1 ns to 20 ms, has been recorded for a glycerol sample upon supercooling, from 300 to 200 K. The satisfactory fitting of the TL signals to the model allows the assessment of relaxation strength and relaxation frequency of the two quantities up to sub-100 MHz, extending the specific heat and thermal expansion spectroscopy by nearly three and eight decades, respectively...
August 21, 2021: Journal of Chemical Physics
#18
JOURNAL ARTICLE
Bridget Walsh, Sharon Christ, Christine Weber
Purpose The purpose of this study is to investigate how epidemiological and clinical factors collectively predict whether a preschooler who is stuttering will persist or recover and to provide guidance on how clinicians can use these factors to evaluate a child's risk for stuttering persistence. Method We collected epidemiological and clinical measures from 52 preschoolers ( M = 54.4 months, SD = 6.7 months; 38 boys and 14 girls) diagnosed as stuttering. We then followed these children longitudinally to document whether they eventually recovered or persisted in stuttering...
August 9, 2021: Journal of Speech, Language, and Hearing Research: JSLHR
#19
MULTICENTER STUDY
Tobias Zimmermann, Jeanne du Fay de Lavallaz, Thomas Nestelberger, Danielle M Gualandro, Ivo Strebel, Patrick Badertscher, Pedro Lopez-Ayala, Velina Widmer, Michael Freese, Òscar Miró, Michael Christ, Louise Cullen, Martin Than, F Javier Martin-Sanchez, Salvatore Di Somma, W Frank Peacock, Dagmar I Keller, Jasper Boeddinghaus, Raphael Twerenbold, Desiree Wussler, Luca Koechlin, Joan E Walter, Franz Bürgler, Nicolas Geigy, Michael Kühne, Tobias Reichlin, Jens Lohrmann, Christian Mueller
AIMS: The aim of this study is to characterize recurrent syncope, including sex-specific aspects, and its impact on death and major adverse cardiovascular events (MACE). METHODS AND RESULTS: We characterized recurrent syncope in a large international multicentre study, enrolling patients ≥40 years presenting to the emergency department (ED) with a syncopal event within the last 12 h. Syncope aetiology was centrally adjudicated by two independent cardiologists using all information becoming available during syncope work-up and long-term follow-up...
December 23, 2020: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
#20
JOURNAL ARTICLE
Simon Christ, Thomas Litschel, Petra Schwille, Reinhard Lipowsky
Reaction-diffusion systems encapsulated within giant unilamellar vesicles (GUVs) can lead to shape oscillations of these vesicles as recently observed for the bacterial Min protein system. This system contains two Min proteins, MinD and MinE, which periodically attach to and detach from the GUV membranes, with the detachment being driven by ATP hydrolysis. Here, we address these shape oscillations within the theoretical framework of curvature elasticity and show that they can be understood in terms of a spontaneous curvature that changes periodically with time...
January 22, 2021: Soft Matter
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