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https://www.readbyqxmd.com/read/29113497/modelling-height-in-adolescence-a-comparison-of-methods-for-estimating-the-age-at-peak-height-velocity
#1
Andrew J Simpkin, Adrian Sayers, Mark S Gilthorpe, Jon Heron, Kate Tilling
BACKGROUND: Controlling for maturational status and timing is crucial in lifecourse epidemiology. One popular non-invasive measure of maturity is the age at peak height velocity (PHV). There are several ways to estimate age at PHV, but it is unclear which of these to use in practice. AIM: To find the optimal approach for estimating age at PHV. SUBJECTS AND METHODS: Methods included the Preece & Baines non-linear growth model, multi-level models with fractional polynomials, SuperImposition by Translation And Rotation (SITAR) and functional data analysis...
November 7, 2017: Annals of Human Biology
https://www.readbyqxmd.com/read/29037006/microrna-150-5p-improves-risk-classification-for-mortality-within-90-days-after-acute-ischemic-stroke
#2
Natalie Scherrer, Francois Fays, Beat Mueller, Andreas Luft, Felix Fluri, Mirjam Christ-Crain, Yvan Devaux, Mira Katan
BACKGROUND AND PURPOSE: Micro ribonucleic acid-150-5p (miR-150-5p) regulates proinflammatory cytokines as well as vessel integrity. We evaluated the incremental prognostic value of logarithm (log) of miR-150-5p plasma levels after ischemic stroke. METHODS: In a prospective cohort study, levels of miR-150-5p were measured within 72 hours of symptom onset in 329 ischemic stroke patients. The outcome measures were unfavorable functional outcome (assessed by the modified Rankin Scale score >2) and mortality within 90 days...
September 2017: Journal of Stroke
https://www.readbyqxmd.com/read/28958780/differential-impacts-of-participation-in-organized-activities-and-maltreatment-types-on-adolescent-academic-and-socioemotional-development
#3
Yoonyoung Kwak, Brittany Mihalec-Adkins, Aura A Mishra, Sharon L Christ
Participation in organized activities has been largely regarded as beneficial for academic and socioemotional development for adolescents, but the impacts of various types of organized activities for adolescents at risk for maltreatment have been rarely tested. In this study, we investigated the differential impacts of five types of maltreatment exposure (physical maltreatment, sexual maltreatment, neglect, other type, and multiple types) on the associations between four types of organized activities (mentored groups, art and music clubs, sport clubs, and academic clubs) and academic and socioemotional development (school engagement, delinquency, depressive symptoms, and trauma symptoms) of adolescents who were investigated by Child Protective Services (CPS) for maltreatment exposure...
September 25, 2017: Child Abuse & Neglect
https://www.readbyqxmd.com/read/28470522/screening-applications-to-test-cellular-fitness-in-transwell-%C3%A2-models-after-nanoparticle-treatment
#4
Bastian Christ, Christina Fey, Alevtina Cubukova, Heike Walles, Sofia Dembski, Marco Metzger
Nanoparticles (NPs) in biotechnology hold great promise for revolutionizing medical treatments and therapies. In order to bring NPs into clinical application there is a number of preclinical in vitro and in vivo tests, which have to be applied before. The initial in vitro evaluation includes a detailed physicochemical characterization as well as biocompatibility tests, among others. For determination of biocompatibility at the cellular level, the correct choice of the in vitro assay as well as NP pretreatment is absolutely essential...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27845521/adolescents-experience-of-parental-psychological-caregiving-and-neglect-construct-development
#5
Sharon L Christ, Yoon Young Kwak, Ting Lu
Psychological or emotional neglect is a recognized form of child maltreatment in the United States. However, neglect as a form of maltreatment and particularly psychological neglect as a subtype are understudied relative to other forms of maltreatment. One reason for this is that few measures of psychological (or emotional) neglect are available and there remains some uncertainty about how to define and measure it. In this article, we put forth a theoretical definition of psychological caregiving, including omission of care or psychological neglect of adolescents by their primary caregivers...
2017: American Journal of Orthopsychiatry
https://www.readbyqxmd.com/read/27179815/impact-of-blandm-1-on-fitness-and-pathogenicity-of-escherichia-coli-and-klebsiella-pneumoniae
#6
Stephan Göttig, Sara Riedel-Christ, Ahmad Saleh, Volkhard A J Kempf, Axel Hamprecht
The objective of this study was to determine whether acquisition of New Delhi metallo-β-lactamase-1 (NDM-1) has an impact on the fitness and virulence of Escherichia coli and Klebsiella pneumoniae. Growth kinetics and the cost of fitness of NDM-1 plasmid carriage were assessed in isogenic E. coli J53 and K. pneumoniae PRZ in vitro by pairwise competition assays. The pathogenicity of NDM-1-expressing E. coli and K. pneumoniae strains and their isogenic controls was analysed in vivo using a Galleria mellonella infection model...
June 2016: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/26320705/working-with-cancer-health-and-employment-among-cancer-survivors
#7
Tainya C Clarke, Sharon L Christ, Hosanna Soler-Vila, David J Lee, Kristopher L Arheart, Guillermo Prado, Alberto Caban Martinez, Lora E Fleming
PURPOSE: Cancer affects a growing proportion of US workers. Factors contributing to whether they continue or return to work after cancer diagnosis include: age, physical and mental health, health insurance, education, and cancer site. The purpose of this study was to assess the complex relationships between health indicators and employment status for adult cancer survivors. METHODS: We analyzed pooled data from the 1997-2012 US National Health Interview Survey (NHIS)...
November 2015: Annals of Epidemiology
https://www.readbyqxmd.com/read/26242864/multicohort-analysis-of-the-maternal-age-effect-on-recombination
#8
Hilary C Martin, Ryan Christ, Julie G Hussin, Jared O'Connell, Scott Gordon, Hamdi Mbarek, Jouke-Jan Hottenga, Kerrie McAloney, Gonnecke Willemsen, Paolo Gasparini, Nicola Pirastu, Grant W Montgomery, Pau Navarro, Nicole Soranzo, Daniela Toniolo, Veronique Vitart, James F Wilson, Jonathan Marchini, Dorret I Boomsma, Nicholas G Martin, Peter Donnelly
Several studies have reported that the number of crossovers increases with maternal age in humans, but others have found the opposite. Resolving the true effect has implications for understanding the maternal age effect on aneuploidies. Here, we revisit this question in the largest sample to date using single nucleotide polymorphism (SNP)-chip data, comprising over 6,000 meioses from nine cohorts. We develop and fit a hierarchical model to allow for differences between cohorts and between mothers. We estimate that over 10 years, the expected number of maternal crossovers increases by 2...
August 5, 2015: Nature Communications
https://www.readbyqxmd.com/read/25905472/primary-cholecystectomy-is-feasible-in-elderly-patients-with-acute-cholecystitis
#9
COMPARATIVE STUDY
Peter C Ambe, Sebastian A Weber, Hildegard Christ, Dirk Wassenberg
BACKGROUND: While early cholecystectomy is generally accepted as the standard procedure for young and fit patients with acute cholecystitis, controversy exits on the management of elderly and severely sick patients. We postulated that primary cholecystectomy is feasible in this subgroup. The aim of this study was to compare the outcomes of young and fit patients to those of elderly patients undergoing surgery for acute cholecystitis. METHODS: The outcomes of elderly patients (≥70 years) undergoing surgery for acute cholecystitis in a primary care center in Germany were retrospectively compared to those of younger patients (<70 years)...
December 2015: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/25538792/cholecystectomy-for-acute-cholecystitis-how-time-critical-are-the-so-called-golden-72%C3%A2-hours-or-better-golden-24%C3%A2-hours-and-silver-25-72-hour-a-case-control-study
#10
Peter Ambe, Sebastian A Weber, Hildegard Christ, Dirk Wassenberg
INTRODUCTION: Early cholecystectomy within 72 hours has been shown to be superior to late or delayed cholecystectomy with regard to outcome and cost of treatment. Recently, immediate cholecystectomy within 24 hours of onset of symptom was proposed as standard procedure for the management of fit patients presenting with acute cholecystitis. We sort to find out if there are any differences in surgical outcomes between patients managed within 24 h and those managed 25-72 h following symptom begin for acute cholecystitis...
2014: World Journal of Emergency Surgery: WJES
https://www.readbyqxmd.com/read/25255074/pharmacokinetics-of-hydromorphone-after-intravenous-and-intramuscular-administration-in-male-rhesus-macaques-macaca-mulatta
#11
Kristi R Kelly, Bruno H Pypendop, Kari L Christe
This study reports the pharmacokinetics of hydromorphone after intravenous and intramuscular administration to rhesus macaques (Macaca mulatta). Hydromorphone (0.075 mg/kg) was administered intravenously as a bolus or intramuscularly on separate occasions to healthy, socially housed, socially reared, adult, intact male rhesus macaques (n = 4). Blood samples were collected prior to and until 10 h after administration. Serum hydromorphone concentrations were analyzed with liquid chromatography-mass spectrometry...
September 2014: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/24647802/isolated-insular-strokes-and-plasma-mr-proanp-levels-are-associated-with-newly-diagnosed-atrial-fibrillation-a-pilot-study
#12
Karl Frontzek, Felix Fluri, Jakob Siemerkus, Beat Müller, Achim Gass, Mirjam Christ-Crain, Mira Katan
INTRODUCTION: In this study, we assessed the relationship of insular strokes and plasma MR-proANP levels with newly diagnosed atrial fibrillation (NDAF). METHODS: This study is based on a prospective acute stroke cohort (http://www.clinicaltrials.gov, NCT00390962). Patient eligibility was dependent on the diagnosis of acute ischemic stroke, absence of previous stroke based on past medical history and MRI, no history of AF and congestive heart failure (cohort A) and, additionally, no stroke lesion size ≥ 20 mL (sub-cohort A*)...
2014: PloS One
https://www.readbyqxmd.com/read/23905732/actinomycetes-with-antimicrobial-activity-isolated-from-paper-wasp-hymenoptera-vespidae-polistinae-nests
#13
Anne A Madden, Andrew Grassetti, Jonathan-Andrew N Soriano, Philip T Starks
Actinomycetes-a group of antimicrobial producing bacteria-have been successfully cultured and characterized from the nest material of diverse arthropods. Some are symbionts that produce antimicrobial chemicals found to protect nest brood and resources from pathogenic microbes. Others have no known fitness relationship with their associated insects, but have been found to produce antimicrobials in vitro. Consequently, insect nest material is being investigated as a new source of novel antimicrobial producing actinomycetes, which could be harnessed for therapeutic potential...
August 2013: Environmental Entomology
https://www.readbyqxmd.com/read/23877944/procalcitonin-to-initiate-or-discontinue-antibiotics-in-acute-respiratory-tract-infections
#14
REVIEW
Philipp Schuetz, Beat Müller, Mirjam Christ-Crain, Daiana Stolz, Michael Tamm, Lila Bouadma, Charles E Luyt, Michel Wolff, Jean Chastre, Florence Tubach, Kristina B Kristoffersen, Olaf Burkhardt, Tobias Welte, Stefan Schroeder, Vandack Nobre, Long Wei, Neera Bhatnagar, Heiner C Bucher, Matthias Briel
BACKGROUND: Acute respiratory infections (ARIs) comprise a large and heterogeneous group of infections including bacterial, viral and other aetiologies. In recent years, procalcitonin - the prohormone of calcitonin - has emerged as a promising marker for the diagnosis of bacterial infections and for improving decisions about antibiotic therapy. Several randomised controlled trials (RCTs) have demonstrated the feasibility of using procalcitonin for starting and stopping antibiotics in different patient populations with acute respiratory infections and different settings ranging from primary care to emergency departments (EDs), hospital wards and intensive care units (ICUs)...
July 2013: Evidence-based Child Health: a Cochrane Review Journal
https://www.readbyqxmd.com/read/23648230/altitudinal-variation-in-haemosporidian-parasite-distribution-in-great-tit-populations
#15
Juan van Rooyen, Fabrice Lalubin, Olivier Glaizot, Philippe Christe
BACKGROUND: One of the major issues concerning disease ecology and conservation is knowledge of the factors that influence the distribution of parasites and consequently disease outbreaks. This study aimed to investigate avian haemosporidian composition and the distribution of these parasites in three altitudinally separated great tit (Parus major) populations in western Switzerland over a three-year period. The objectives were to determine the lineage diversity of parasites occuring across the study populations and to investigate whether altitudinal gradients govern the distribution of haemosporidian parasites by lineage...
2013: Parasites & Vectors
https://www.readbyqxmd.com/read/23366849/prosthesis-user-in-the-loop-a-user-specific-biomechanical-modeling-and-simulation-environment
#16
J Wojtusch, P Beckerle, O Christ, K Wolff, O von Stryk, S Rinderknecht, J Vogt
In this paper, a novel biomechanical modeling and simulation environment with an emphasis on user-specific customization is presented. A modular modeling approach for multi-body systems allows a flexible extension by specific biomechanical modeling elements and enables an efficient application in dynamic simulation and optimization problems. A functional distribution of model description and model parameter data in combination with standardized interfaces enables a simple and reliable replacement or modification of specific functional components...
2012: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/22972110/procalcitonin-to-initiate-or-discontinue-antibiotics-in-acute-respiratory-tract-infections
#17
REVIEW
Philipp Schuetz, Beat Müller, Mirjam Christ-Crain, Daiana Stolz, Michael Tamm, Lila Bouadma, Charles E Luyt, Michel Wolff, Jean Chastre, Florence Tubach, Kristina B Kristoffersen, Olaf Burkhardt, Tobias Welte, Stefan Schroeder, Vandack Nobre, Long Wei, Neera Bhatnagar, Heiner C Bucher, Matthias Briel
BACKGROUND: Acute respiratory infections (ARIs) comprise a large and heterogeneous group of infections including bacterial, viral and other aetiologies. In recent years, procalcitonin - the prohormone of calcitonin - has emerged as a promising marker for the diagnosis of bacterial infections and for improving decisions about antibiotic therapy. Several randomised controlled trials (RCTs) have demonstrated the feasibility of using procalcitonin for starting and stopping antibiotics in different patient populations with acute respiratory infections and different settings ranging from primary care to emergency departments (EDs), hospital wards and intensive care units (ICUs)...
September 12, 2012: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/21695560/the-subthreshold-autism-trait-questionnaire-satq-development-of-a-brief-self-report-measure-of-subthreshold-autism-traits
#18
Stephen M Kanne, Jennifer Wang, Shawn E Christ
The current study was motivated by a need for a self-report questionnaire that assesses a broad range of subthreshold autism traits, is brief and easily administered, and is relevant to the general population. An initial item pool was administered to 1,709 students. Structural validity analysis resulted in a 24-item questionnaire termed the Subthreshold Autism Trait Questionnaire (SATQ; Cronbach's alpha coefficient = .73, test-retest reliability = .79). An exploratory factor analysis suggested 5 factors...
May 2012: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/21682920/two-logistic-models-for-the-prediction-of-hypothyroidism-in-pregnancy
#19
Anthony U Mbah, Emmanuel C Ejim, Obinna D Onodugo, Francis O Ezugwu, Matthew I Eze, Peter O Nkwo, Winston C Ugbajah
BACKGROUND: The mounting evidence linking hypothyroidism during pregnancy with poor pregnancy outcome underscores the need for screening and, therefore, a search for more reliable and cheaper screening methods. METHODS: The study was conducted in two phases. The phase one study comprised of healthy women in different stages of pregnancy who attended routine antenatal clinic at St Theresa's Maternity Hospital, Enugu, Nigeria from September 6 to October 18 1994. In this study the variables compared between the hypothyroid and non-hypothyroid pregnant women were maternal age, the number of the pregnancy or gravidity, gestational age, social class, body weight, height, the clinically assessed size of the thyroid gland, serum free thyroxin (FT4) and serum thyrotrophin (TSH)...
2011: BMC Research Notes
https://www.readbyqxmd.com/read/21447747/regulation-of-whole-body-energy-homeostasis-with-growth-hormone-replacement-therapy-and-endurance-exercise
#20
Robert Oosterhof, Michael Ith, Roman Trepp, Emanuel Christ, Martin Flück
We hypothesized that network analysis is useful to expose coordination between whole body and myocellular levels of energy metabolism and can identify entities that underlie skeletal muscle's contribution to growth hormone-stimulated lipid handling and metabolic fitness. We assessed 112 metabolic parameters characterizing metabolic rate and substrate handling in tibialis anterior muscle and vascular compartment at rest, after a meal and exercise with growth hormone replacement therapy (GH-RT) of hypopituitary patients (n = 11)...
June 28, 2011: Physiological Genomics
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