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https://www.readbyqxmd.com/read/29283064/glycogen-synthase-kinase-3%C3%AE-as-a-putative-therapeutic-target-for-bipolar-disorder
#1
Manoj P Dandekar, Samira S Valvassori, Gustavo Colombo Dal-Pont, Joao Quevedo
BACKGROUND: Bipolar disorder (BD) is a debilitating mental ailment characterized by recurrent episodes of mania and depression. Primary mood-stabilizing drugs like lithium and valproate alleviate the hypomanic or mild to moderate manic episodes in patients with BD. One of the extensively studied underlying mechanisms for these pharmacological interventions is inhibition of intracellular signaling cascades associated with glycogen synthase kinase-3 beta (GSK-3β), a multi-functional serine-threonine kinase...
December 27, 2017: Current Drug Metabolism
https://www.readbyqxmd.com/read/28976944/the-new-news-about-lithium-an-underutilized-treatment-in-the-united-states
#2
Robert M Post
Lithium use for the treatment of mood disorders remains quite low, particularly in the United States compared with some European countries. Mogens Schou pioneered the study of lithium for prophylaxis of the recurrent mood disorder and encouraged its greater use. In an effort to further address the appropriate role of this drug, the multiple assets of lithium beyond its well-known antimanic effect are reviewed, and a brief summary of its side effects is outlined. It appears that lithium has positive effects in depression and suicide prevention, cognition, and reducing the incidence of dementia...
October 4, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28858537/anti-inflammatory-treatments-for-mood-disorders-systematic-review-and-meta-analysis
#3
Muhammad I Husain, Rebecca Strawbridge, Paul Ra Stokes, Allan H Young
BACKGROUND: Recent studies suggest that anti-inflammatory medication may play a role in the treatment of mood disorders. AIMS: The purpose of this study was to determine the efficacy of anti-inflammatory drugs in patients with major depressive disorder and bipolar disorder. METHOD: The Cochrane Central Register of Controlled Trials, PubMed, EMBASE, PsychINFO and Clinicaltrials.gov were searched from inception until 15 April 2017 for completed and on-going randomized controlled trials of anti-inflammatory agents for major depressive disorder and bipolar disorder...
September 2017: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/28857068/antimanic-efficacy-of-a-novel-kv3-potassium-channel-modulator
#4
Puja K Parekh, Michelle M Sidor, Andrea Gillman, Darius Becker-Krail, Letizia Bettelini, Roberto Arban, Giuseppe S Alvaro, Erika Zambello, Chiara Mutinelli, Yanhua Huang, Charles H Large, Colleen A McClung
Kv3.1 and Kv3.2 voltage-gated potassium channels are expressed on parvalbumin-positive GABAergic interneurons in corticolimbic brain regions and contribute to high-frequency neural firing. The channels are also expressed on GABAergic neurons of the basal ganglia, substantia nigra, and ventral tegmental area (VTA) where they regulate firing patterns critical for movement control, reward, and motivation. Modulation of Kv3.1 and Kv3.2 channels may therefore have potential in the treatment of disorders in which these systems have been implicated, such as bipolar disorder...
August 31, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28852259/chlorpromazine-as-prophylaxis-for-bipolar-disorder-with-treatment-and-electroconvulsive-therapy-refractory-mania-old-horse-new-trick
#5
Tamonud Modak, Saurabh Kumar, Arghya Pal, Rishab Gupta, Raman Deep Pattanayak, Sudhir Kumar Khandelwal
A 22-year-old male diagnosed with bipolar affective disorder presented to us with a 3(rd) episode mania resistant to both olanzapine and haloperidol as well as electroconvulsive therapy. He, however, responded to chlorpromazine (CPZ) which was also effective as a mood stabilizer. The patient had a relapse of his illness when CPZ was stopped and responded again when it was started. The case demonstrates that CPZ may have a role in as both an anti-manic agent and for the maintenance for bipolar disorders. The possible underlying mechanism for this role is also discussed...
July 2017: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/28271741/the-preclinical-discovery-and-development-of-quetiapine-for-the-treatment-of-mania-and-depression
#6
REVIEW
Aline Silva de Miranda, Fabrício A Moreira, Antônio Lúcio Teixeira
Bipolar disorder is a chronic disabling condition characterized by alternating manic and depressive episodes. Bipolar disorder has been associated with functional impairment, poor quality of life, morbidity and mortality. Despite its significant clinical, social and economic burden, treatment options for bipolar disorder are still limited. Several clinical trials have shown efficacy of the atypical antipsychotic quetiapine (QTP) in the treatment of this condition. However, the mechanisms underlying the antidepressant and anti-manic effects of QTP remain poorly understood...
May 2017: Expert Opinion on Drug Discovery
https://www.readbyqxmd.com/read/27726886/-concordance-between-hospital-prescriptions-and-recommendations-in-the-treatment-of-mania
#7
Edouard-Jules Laforgue, Samuel Bulteau, Jennyfer Cholet, Caroline Victorri-Vigneau, Marie Guitteny, Nicolas Mauduit, Jean-Marie Vanelle, Anne Sauvaget
PURPOSE: There are differences between recommendations and practice in the pharmacological treatment of acute mania. OBJECTIVE: The objective was to assess conformity of the anti-manic prescription between national recommendations (Haute Autorité de santé [French health authority, HAS] and "résumé des caractéristiques du produit" [product characteristics, RCP]) and clinical practice. METHODS: We observed the drug prescriptions of in-patients for a manic episode...
June 2017: Thérapie
https://www.readbyqxmd.com/read/27724879/prevalence-and-appropriateness-of-psychotropic-medication-prescribing-in-a-nationally-representative-cross-sectional-survey-of-male-and-female-prisoners-in-england
#8
Lamiece Hassan, Jane Senior, Roger T Webb, Martin Frisher, Mary P Tully, David While, Jenny J Shaw
BACKGROUND: Mental illness is highly prevalent among prisoners. Although psychotropic medicines can ameliorate symptoms of mental illness, prescribers in prisons must balance clinical needs against risks to safety and security. Concerns have been raised at the large number of prisoners reportedly receiving psychotropic medicines in England. Nonetheless, unlike for the wider community, robust prescribing data are not routinely available for prisons. We investigated gender-specific patterns in the prevalence and appropriateness of psychotropic prescribing in English prisons...
October 10, 2016: BMC Psychiatry
https://www.readbyqxmd.com/read/27703531/lithium-chloride-has-a-biphasic-effect-on-prostate-cancer-stem-cells-and-a-proportional-effect-on-midkine-levels
#9
Mine Erguven, Gulperi Oktem, Ali Nail Kara, Ayhan Bilir
Prostate cancer (PCa) is the second most frequent type of cancer in men worldwide and the levels of differentiation growth factor midkine (MK) are increased in PCa. Cancer and/or the treatment process itself may lead to psychiatric disorders. Lithium chloride (LiCl) has anti-manic properties and has been used in cancer therapy; however, it has a queried safety profile. In addition, cancer stem cells are responsible for the heterogeneous phenotype of tumor cells; they are involved in progression, metastasis, recurrence and therapy resistance in various cancer types...
October 2016: Oncology Letters
https://www.readbyqxmd.com/read/27646265/pde11a-negatively-regulates-lithium-responsivity
#10
G Pathak, M J Agostino, K Bishara, W R Capell, J L Fisher, S Hegde, B A Ibrahim, K Pilarzyk, C Sabin, T Tuczkewycz, S Wilson, M P Kelly
Lithium responsivity in patients with bipolar disorder has been genetically associated with Phosphodiesterase 11A (PDE11A), and lithium decreases PDE11A mRNA in induced pluripotent stem cell-derived hippocampal neurons originating from lithium-responsive patients. PDE11 is an enzyme uniquely enriched in the hippocampus that breaks down cyclic AMP and cyclic GMP. Here we determined whether decreasing PDE11A expression is sufficient to increase lithium responsivity in mice. In dorsal hippocampus and ventral hippocampus (VHIPP), lithium-responsive C57BL/6J and 129S6/SvEvTac mice show decreased PDE11A4 protein expression relative to lithium-unresponsive BALB/cJ mice...
September 20, 2016: Molecular Psychiatry
https://www.readbyqxmd.com/read/27527887/-mania-induced-by-antibiotic-therapy
#11
T R W M Walrave, S Mohammad, R R Ploeger
We report two cases of adults who developed mania after taking the antibiotic clarithromycin. Clarithromycin is a frequently used antibiotic, but it can lead to a rare but significant psychiatric complication in the form of a manic episode. Mania is commonly associated with bipolar disorder, but the causes can be pharmacological, metabolic or neurologic, particularly when it occurs in patients who themselves or whose families have no past history of psychiatric illness. New-onset mania calls for detailed clinical and laboratory testing and neuro-imaging so that somatic causes can be ruled out...
2016: Tijdschrift Voor Psychiatrie
https://www.readbyqxmd.com/read/27444123/interaction-between-dorsal-hippocampal-nmda-receptors-and-lithium-on-spatial-learning-consolidation-in-rats
#12
Leila Parsaei, Anahita Torkaman-Boutorabi, Fereshteh Asadi, Mohammad-Reza Zarrindast
Previous investigations have shown that NMDA receptors play an important role in learning and memory process. Lithium is a primary drug for management and prophylaxis of bipolar disorder. It can regulate signal transduction pathways in several regions of the brain and alter the function of several neurotransmitter systems involved in memory processes. The present study aimed to test the interaction of NMDA glutamatergic system of the CA1 region of dorsal hippocampus and lithium on spatial learning. Spatial memory was assessed in Morris water maze task by a single training session of eight trials followed by a probe trial and visible test 24h later...
October 2016: Brain Research Bulletin
https://www.readbyqxmd.com/read/26459714/selective-disruption-of-dopamine-d2-receptors-beta-arrestin2-signaling-by-mood-stabilizers
#13
Thomas Del' Guidice, Jean-Martin Beaulieu
Mood stabilizers are a heterogeneous class of drugs having antidepressant and anti-manic effects in bipolar disorders, depression and schizophrenia. Despite wide clinical applications, the mechanisms underlying their shared actions and therapeutic specificity are unknown. Here, we examine the effects of the structurally unrelated mood stabilizers lamotrigine, lithium and valproate on G protein and beta-arrestin-dependent components of dopamine D2 receptor signaling and assess their contribution to the behavioral effects of these drugs...
June 2015: Journal of Receptor and Signal Transduction Research
https://www.readbyqxmd.com/read/26363613/inflammation-as-a-neurobiological-substrate-of-cognitive-impairment-in-bipolar-disorder-evidence-pathophysiology-and-treatment-implications
#14
REVIEW
Joshua D Rosenblat, Elisa Brietzke, Rodrigo B Mansur, Nadia A Maruschak, Yena Lee, Roger S McIntyre
BACKGROUND: Bipolar disorder (BD) has been associated with cognitive impairment during depressed, manic and euthymic periods. Inflammation has been shown to be involved in the pathophysiology of BD and cognitive impairment. METHODS: For this systematic review, the MEDLINE/PubMed, Embase, Google Scholar and ClinicalTrials.gov databases were searched for relevant articles assessing the association between cognitive function and inflammatory markers in BD subjects...
December 1, 2015: Journal of Affective Disorders
https://www.readbyqxmd.com/read/26330288/randomized-placebo-controlled-adjunctive-study-of-armodafinil-for-bipolar-i-depression-implications-of-novel-drug-design-and-heterogeneity-of-concurrent-bipolar-maintenance-treatments
#15
Mark A Frye, Jess Amchin, Michael Bauer, Caleb Adler, Ronghua Yang, Terence A Ketter
BACKGROUND: Some, but not all, prior investigations suggest armodafinil may have utility as an adjunctive treatment in bipolar I depression. METHODS: Multicenter, randomized, double-blind study in patients aged 18 to 65 years experiencing a depressive episode despite maintenance therapy for bipolar I disorder. Patients were randomized to receive adjunctive armodafinil 150 mg/day or adjunctive placebo for 8 weeks. Primary efficacy outcome was change from baseline in 30-Item Inventory of Depressive Symptomatology-Clinician-Rated (IDS-C30) total score at week 8...
December 2015: International Journal of Bipolar Disorders
https://www.readbyqxmd.com/read/26325389/production-of-nurr-1-specific-polyclonal-antibodies-free-of-cross-reactivity-against-its-close-homologs-nor1-and-nur77
#16
Pierre Leblanc, Minho Moon, Woori Kim, Inhye Jeong, Chun-Hyung Kim, Kwang-Soo Kim
The nuclear receptor subfamily 4 (NR4A) is composed of 3 related proteins sharing a DNA binding domain (DBD) and a ligand-binding domain (LBD). The nuclear receptor related 1 protein (Nurr1 or NR4A2) plays a key role in the maintenance of the dopaminergic system. Dopamine dysfunctions associated with the Nurr1 gene include Parkinson's disease, schizophrenia and manic depression among others. Furthermore, recent evidence indicates that Nurr1 is also expressed in other brain areas such as the hippocampus and plays critical roles for learning and memory...
2015: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/26311765/trpm2-a-susceptibility-gene-for-bipolar-disorder-regulates-glycogen-synthase-kinase-3-activity-in-the-brain
#17
Yongwoo Jang, Sung Hoon Lee, Byeongjun Lee, Seungmoon Jung, Arshi Khalid, Kunitoshi Uchida, Makoto Tominaga, Daejong Jeon, Uhtaek Oh
UNLABELLED: Bipolar disorder (BD) is a psychiatric disease that causes mood swings between manic and depressed states. Although genetic linkage studies have shown an association between BD and TRPM2, a Ca(2+)-permeable cation channel, the nature of this association is unknown. Here, we show that D543E, a mutation of Trpm2 that is frequently found in BD patients, induces loss of function. Trpm2-deficient mice exhibited BD-related behavior such as increased anxiety and decreased social responses, along with disrupted EEG functional connectivity...
August 26, 2015: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/26291962/celecoxib-adjunctive-therapy-for-acute-bipolar-mania-a-randomized-double-blind-placebo-controlled-trial
#18
RANDOMIZED CONTROLLED TRIAL
Somayeh Arabzadeh, Niusha Ameli, Atefeh Zeinoddini, Farzin Rezaei, Mehdi Farokhnia, Payam Mohammadinejad, Ali Ghaleiha, Shahin Akhondzadeh
OBJECTIVES: Recent research has focused on the inflammatory cascade as a key culprit in the etiology of bipolar disorder. We hypothesized that celecoxib, via its anti-inflammatory properties, may have a therapeutic role in mood disorder. METHODS: Forty-six inpatients with the diagnosis of acute bipolar mania without psychotic features participated in a parallel, randomized, double-blind, placebo-controlled trial, and underwent six weeks of treatment with either celecoxib (400 mg daily) or placebo as an adjunctive treatment to sodium valproate...
September 2015: Bipolar Disorders
https://www.readbyqxmd.com/read/26219985/chronic-treatment-with-mood-stabilizer-lithium-inhibits-amphetamine-induced-risk-taking-manic-like-behaviors
#19
Zhu Zhou, Ying Wang, Hua Tan, Veni Bharti, Yi Che, Jun-Feng Wang
A lack of behavioral tests and animal models for manic-depressive bipolar disorder is recognized as an important factor limiting development of novel pharmaceutical treatments for the disorder. Repeated amphetamine-induced hyperactivity is a commonly used animal model for mania. However, hyperactivity represents only one facet of mania and is also seen in other disorders. Increased engagement in risk taking behavior is frequently observed in the manic phase of bipolar disorder. In the present study, we analyzed the effect of the most commonly used mood stabilizer lithium on repeated amphetamine treatment-induced risk-taking behaviors in rats using elevated plus maze and wire-beam bridge tests...
August 31, 2015: Neuroscience Letters
https://www.readbyqxmd.com/read/26199781/anti-nmda-receptor-encephalitis-in-a-patient-with-previous-psychosis-and-neurological-abnormalities-a-diagnostic-challenge
#20
R David Heekin, Maria C Catalano, Alfred T Frontera, Glenn Catalano
Anti-N-methyl-D-aspartate (NMDA) receptor encephalitis is an autoimmune disorder characterized by IgG autoantibodies directed against the NR1 subunit of the NMDA glutamate receptor. Psychiatric symptoms are common and include psychosis, mania, depressed mood, aggression, and speech abnormalities. Neurological symptoms such as seizures, decreased responsiveness, dyskinesias, and other movement abnormalities and/or autonomic instability are frequently seen as well. We present the case of a woman who was followed up at our facility for over 14 years for the treatment of multiple neuropsychiatric symptoms...
2015: Case Reports in Psychiatry
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