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https://www.readbyqxmd.com/read/28719146/natural-compounds-in-cancer-prevention-effects-of-coffee-extracts-and-their-main-polyphenolic-component-5-cqa-on-oncogenic-ras-proteins
#1
Alessandro Palmioli, Carlotta Cairamelli, Renata Tisi, Michela Spinelli, Gaia De Sanctis, Elena Sacco, Cristina Airoldi
Recent epidemiological studies demonstrate that consumption of healthy foods, especially rich in polyphenols content, might reduce the incidence of cancer and degenerative diseases. In particular, chlorogenic acids (CGAs) occur ubiquitously in food, representing the most abundant polyphenols in the human diet. A number of CGA beneficial biological effects, including anti-inflammatory activity, anti-carcinogenic activity and protection against neurodegenerative diseases have been reported. However, the molecular mechanisms at the basis of these biological activities have not yet been investigated in depth...
July 18, 2017: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/28699042/is-the-non-sentinel-lymph-node-compartment-the-next-site-for-melanoma-progression-from-the-sentinel-lymph-node-compartment-in-the-regional-nodal-basin
#2
Andrei Rios-Cantu, Ying Lu, Victor Melendez-Elizondo, Michael Chen, Alejandra Gutierrez-Range, Niloofar Fadaki, Suresh Thummala, Carla West-Coffee, James Cleaver, Mohammed Kashani-Sabet, Stanley P L Leong
Melanoma patients with additional positive lymph nodes in the completion lymph node dissection (CLND) following a positive sentinel lymph node (SLN) biopsy would have a poorer prognosis than patients with no additional positive lymph nodes. We hypothesize that the progression of disease from the SLN to the non-SLN compartment is orderly and is associated with the worsening of the disease status. Thus, the SLN and non-SLN compartments are biologically different in that cancer cells, in general, arrive in the SLN compartment before spreading to the non-SLN compartment...
July 11, 2017: Clinical & Experimental Metastasis
https://www.readbyqxmd.com/read/28698757/new-safety-margins-for-melanoma-surgery-nice-possibility-for-drinking-of-just-that-cup-of-coffee
#3
Georgi Tchernev, Anastasiya Atanasova Chokoeva
BACKGROUND: The American Joint Committee on Cancer (AJCC's) skin melanoma surgical treatment recommendations from 2011 are characterised by a prima facie "freedom of choice" regarding how extensive should be the excisions for melanomas with tumour thickness up to 2 mm and melanoma in situ. It is unclear why the recommended surgical security margins vary between 0.5 and 1 cm for melanoma in situ, whereas for melanomas with a tumour thickness of up to 1.99 mm, the range of variation is also between 1 and 2 cm, without specifying when the surgical field should be broader and, narrower, accordingly...
June 15, 2017: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/28693281/coffee-reduces-kras-expression-in-caco-2-human-colon-carcinoma-cells-via-regulation-of-mirnas
#4
Takuya Nakayama, Megumi Funakoshi-Tago, Hiroomi Tamura
Previous epidemiological studies have demonstrated that moderate coffee consumption is associated with a lower risk of certain types of cancer, particularly colon cancer. To elucidate the molecular basis for this protective action, the effect of coffee on Caco-2 human colon carcinoma cells was investigated. Low concentrations of coffee (<5%) inhibited proliferation of Caco-2 cells without affecting cell viability. Coffee also reduced KRAS proto-oncogene, GTPase (KRAS) gene expression in a dose-dependent manner; however, caffeine, caffeic acid and chlorogenic acid, three major constituents of coffee, did not exhibit this effect...
July 2017: Oncology Letters
https://www.readbyqxmd.com/read/28693038/coffee-drinking-and-mortality-in-10-european-countries-a-multinational-cohort-study
#5
Marc J Gunter, Neil Murphy, Amanda J Cross, Laure Dossus, Laureen Dartois, Guy Fagherazzi, Rudolf Kaaks, Tilman Kühn, Heiner Boeing, Krasimira Aleksandrova, Anne Tjønneland, Anja Olsen, Kim Overvad, Sofus Christian Larsen, Maria Luisa Redondo Cornejo, Antonio Agudo, María José Sánchez Pérez, Jone M Altzibar, Carmen Navarro, Eva Ardanaz, Kay-Tee Khaw, Adam Butterworth, Kathryn E Bradbury, Antonia Trichopoulou, Pagona Lagiou, Dimitrios Trichopoulos, Domenico Palli, Sara Grioni, Paolo Vineis, Salvatore Panico, Rosario Tumino, Bas Bueno-de-Mesquita, Peter Siersema, Max Leenders, Joline W J Beulens, Cuno U Uiterwaal, Peter Wallström, Lena Maria Nilsson, Rikard Landberg, Elisabete Weiderpass, Guri Skeie, Tonje Braaten, Paul Brennan, Idlir Licaj, David C Muller, Rashmi Sinha, Nick Wareham, Elio Riboli
Background: The relationship between coffee consumption and mortality in diverse European populations with variable coffee preparation methods is unclear. Objective: To examine whether coffee consumption is associated with all-cause and cause-specific mortality. Design: Prospective cohort study. Setting: 10 European countries. Participants: 521 330 persons enrolled in EPIC (European Prospective Investigation into Cancer and Nutrition)...
July 11, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28693036/association-of-coffee-consumption-with-total-and-cause-specific-mortality-among-nonwhite-populations
#6
Song-Yi Park, Neal D Freedman, Christopher A Haiman, Loïc Le Marchand, Lynne R Wilkens, Veronica Wendy Setiawan
Background: Coffee consumption has been associated with reduced risk for death in prospective cohort studies; however, data in nonwhites are sparse. Objective: To examine the association of coffee consumption with risk for total and cause-specific death. Design: The MEC (Multiethnic Cohort), a prospective population-based cohort study established between 1993 and 1996. Setting: Hawaii and Los Angeles, California. Participants: 185 855 African Americans, Native Hawaiians, Japanese Americans, Latinos, and whites aged 45 to 75 years at recruitment...
July 11, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28668478/preliminary-evidence-of-polymorphisms-of-cell-cycle-regulatory-genes-and-their-roles-in-urinary-tract-urothelial-cancer-susceptibility-and-prognosis-in-a-taiwan-population
#7
Ying-Chu Lin, Tzyh-Chyuan Hour, Yu-Chieh Tsai, Shu-Pin Huang, Wen-Jeng Wu, Chung-Hsin Chen, Yeong-Shiau Pu, Shiu-Dong Chung, Chao-Yuan Huang
OBJECTIVE: Our aims were to investigate the correlations between polymorphisms in the cell cycle regulatory genes (aurora kinase A [AURKA], survivin, p21, and p53) and UC risk and prognosis. PATIENTS AND METHODS: This study recruited 185 patients with UTUC, 46 patients with bladder cancer, and 188 hospital controls. Demographic data and possible confounding factors were collected using a standardized questionnaire. Genotyping was determined by real-time polymerase chain reaction and TaqMan probe methods...
June 28, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28662634/healthy-dietary-patterns-decrease-the-risk-of-colorectal-cancer-in-the-mecca-region-saudi-arabia-a-case-control-study
#8
Firas S Azzeh, Eyad M Alshammari, Awfa Y Alazzeh, Abdelelah S Jazar, Ibrahim R Dabbour, Hani A El-Taani, Ahmed A Obeidat, Fayrooz A Kattan, Sufyan H Tashtoush
BACKGROUND: Colorectal cancer (CRC) is the first most common cancer in males and the third most common cancer in females in Saudi Arabia. Dietary habits are strongly associated with the inhibition or proliferation of malignancy. Therefore, this study is aiming to investigate the risks and protective benefits of dietary factors affecting CRC in the Mecca region of Saudi Arabia. METHODS: A case-control study was conducted from June 2014 to March 2015. One hundred thirty-seven patients with colon and/or rectal cancer were recruited in the case group, while 164 healthy participants were recruited in the control group...
June 29, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28624617/core-shell-iron-oxide-layered-double-hydroxide-high-electrochemical-sensing-performance-of-h2o2-biomarker-in-live-cancer-cells-with-plasma-therapeutics
#9
Muhammad Asif, Hongwei Liu, Ayesha Aziz, Haitao Wang, Zhengyun Wang, Muhammad Ajmal, Fei Xiao, Hongfang Liu
In this work, we develop a new type of multifunctional core-shell nanomaterial by controllable integration of CuAl layered double hydroxides (LDHs) over the surface of iron oxides (Fe3O4) nanospheres (NSs) to fabricate (Fe3O4@CuAl NSs) hybrid material with interior tunability of LDH phase and explore its practical application in ultrasensitive detection of emerging biomarker, i.e., H2O2 as cancer diagnostic probe. In addition, atmospheric pressure plasmas (APPs) have also been used as potential therapeutic approach for cancer treatment...
June 3, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28612129/coffee-consumption-and-risk-of-non-hodgkin-s-lymphoma-evidence-from-the-italian-multicentre-case-control-study
#10
Stefano Parodi, Franco Domenico Merlo, Emanuele Stagnaro
PURPOSE: Several investigations have analysed the association between coffee intake and risk of cancer. Contradictory results were reported by the studies conducted in non-Hodgkin's lymphomas (NHL) few of which report results according to main NHL subgroups. The present study is aimed at evaluating the association between coffee consumption and the risk of NHL by analysing data from a large Italian multicentre case-control study that included 1,418 interviewed cases (1,301 B cell and 117 T cell NHL), diagnosed between 1990 and 1993, and 1,774 population healthy controls...
June 13, 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28588600/date-palm-tree-phoenix-dactylifera-l-natural-products-and-therapeutic-options
#11
REVIEW
Reem A Al-Alawi, Jawhara H Al-Mashiqri, Jawaher S M Al-Nadabi, Badria I Al-Shihi, Younis Baqi
Many plants, including some of the commonly consumed herbs and spices in our daily food, can be safely and effectively used to prevent and/or treat some health concerns. For example, caffeine the active ingredient found in coffee beans (Coffea), shows biological activity in the treatment of the central nervous system (CNS) disorders, indole-3-carbinol, and 3,3'-diindolylmethane are both broccoli (Brassica oleracea) derived phytochemicals with potential anti-cancer activity, and resveratrol, isolated from grape (Vitis vinifera), is reported to extend lifespan and provide cardio-neuro-protective, anti-diabetic, and anti-cancer effects...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28578041/microbiota-source-impact-in-vitro-metabolite-colonic-production-and-anti-proliferative-effect-of-spent-coffee-grounds-on-human-colon-cancer-cells-ht-29
#12
Angélica María Hernández-Arriaga, B Dave Oomah, Rocio Campos-Vega
Human gut flora-mediated non-digestible fraction of spent coffee grounds (hgf-NDSCG) was evaluated for its chemopreventive effect and molecular mechanisms involved on human colon adenocarcinoma HT-29 cell survival using two different microbiota source [lean (L) and overweight (OW)]. The source of human gut flora (hgf) (L or OW) affected the pH of hgf-NDSCG only minimally, but linearly reduced those of hgf-inulin. The variability between lean and overweight microbiota was characterized by the metabolism and/or bioaccessibility of different phenolic metabolites, their intermediate and end products as well as by variable time courses...
July 2017: Food Research International
https://www.readbyqxmd.com/read/28566532/risk-and-protective-factors-for-the-occurrence-of-sporadic-pancreatic-endocrine-neoplasms
#13
Roberto Valente, Alastair J Hayes, Sven-Petter Haugvik, Per Hedenström, Darko Siuka, Emilie Korsæth, Daniel Kaemmerer, Stuart Michael Robinson, Patrick Maisonneuve, Gianfranco Delle Fave, Bjorn Lindkvist, Gabriele Capurso
Pancreatic neuroendocrine neoplasms (PNENs) represent 10% of all pancreatic tumors by prevalence. Their incidence has reportedly increased over recent decades in parallel with that of pancreatic adenocarcinoma. PNENs are relatively rare and of the few institutions that have published potential risk factors, findings have been heterogenous. AIM: To investigate the association between potential risk and protective factors for the occurrence of sporadic PNENs across a European population from several institutions...
May 31, 2017: Endocrine-related Cancer
https://www.readbyqxmd.com/read/28560871/forecasting-chronic-diseases-using-data-fusion
#14
Evrim Acar, Gözde Gürdeniz, Francesco Savorani, Louise Hansen, Anja Olsen, Anne Tjønneland, Lars Ove Dragsted, Rasmus Bro
Data fusion, that is, extracting information through the fusion of complementary data sets, is a topic of great interest in metabolomics because analytical platforms such as liquid chromatography-mass spectrometry (LC-MS) and nuclear magnetic resonance (NMR) spectroscopy commonly used for chemical profiling of biofluids provide complementary information. In this study, with a goal of forecasting acute coronary syndrome (ACS), breast cancer, and colon cancer, we jointly analyzed LC-MS, NMR measurements of plasma samples, and the metadata corresponding to the lifestyle of participants...
June 9, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28558558/three-cups-of-espresso-a-day-may-halve-prostate-cancer-risk
#15
(no author information available yet)
Drinking more than three cups of Italian-style espresso coffee every day could halve the risk of prostate cancer in men.
May 31, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28535255/tea-and-coffee-consumption-in-relation-to-dna-methylation-in-four-european-cohorts
#16
Weronica E Ek, Elmar W Tobi, Muhammad Ahsan, Erik Lampa, Erica Ponzi, Soterios A Kyrtopoulos, Panagiotis Georgiadis, L H Lumey, Bastiaan T Heijmans, Maria Botsivali, Ingvar A Bergdahl, Torgny Karlsson, Mathias Rask-Andersen, Domenico Palli, Erik Ingelsson, Åsa K Hedman, Lena M Nilsson, Paolo Vineis, Lars Lind, James M Flanagan, Åsa Johansson
Lifestyle factors, such as food choices and exposure to chemicals, can alter DNA methylation and lead to changes in gene activity. Two such exposures with pharmacologically active components are coffee and tea consumption. Both coffee and tea has been suggested to play an important role in modulating disease-risk in humans by suppressing tumour progression, decreasing inflammation and influencing estrogen metabolism. These mechanisms may be mediated by changes in DNA methylation.To investigate if DNA methylation in blood is associated with coffee and tea consumption we performed a genome-wide DNA methylation study for coffee and tea consumption in four European cohorts (N = 3,096)...
May 23, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28531805/troxerutin-txn-potentiated-5-fluorouracil-5-fu-treatment-of-human-gastric-cancer-through-suppressing-stat3-nf-%C3%AE%C2%BAb-and-bcl-2-signaling-pathways
#17
Gui-Yun Xu, Xiao-Jun Tang
Gastric cancer still presents a significant problem for public health worldwide. Troxerutin (TXN), a flavonoid present in tea, coffee, cereal grains, and a variety of fruits and vegetables, exhibits various pharmacological and biological activities in vitro and in vivo. We investigated the ability of TXN to reverse the in vitro and in vivo drug resistance of human gastric cancer cells, which were resistant to treatment of 5-Fluorouracil (5-FU). 5-Fu is a pyrimidine analog, which is widely used in the treatment of cancers...
August 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28506698/antiproliferative-and-cytotoxic-effects-of-green-coffee-and-yerba-mate-extracts-their-main-hydroxycinnamic-acids-methylxanthine-and-metabolites-in-different-human-cell-lines
#18
M Amigo-Benavent, S Wang, R Mateos, B Sarriá, L Bravo
This work aimed at studying the effects of green coffee bean (GCBE) and yerba mate (YME) extracts, their main phenolic components (5-caffeoylquinic acid, 5-CQA; 3,5-dicaffeoylquinic acid, 3,5-DCQA) and metabolites (ferulic acid, FA; caffeic acid, CA; dihydrocaffeic acid, DHCA; and dihydroferulic acid, DHFA) along with caffeine (CAF) on the viability and proliferation of different human cell lines. Extracts (10-1000 μg/mL) and standards (10-1000 μM) were assayed in colon (Caco-2), lung (A549), oesophageal (OE-33), urinary bladder (T24) human carcinoma cells, and a non-cancer cell line (CCD-18Co)...
August 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28488131/erratum-to-coffee-tea-and-caffeine-intake-and-the-risk-of-non-melanoma-skin-cancer-a-review-of-the-literature-and-meta-analysis
#19
Saverio Caini, Maria Sofia Cattaruzza, Benedetta Bendinelli, Giulio Tosti, Giovanna Masala, Patrizia Gnagnarella, Melania Assedi, Ignazio Stanganelli, Domenico Palli, Sara Gandini
No abstract text is available yet for this article.
May 9, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/28479483/coffee-and-autoimmunity-more-than-a-mere-hot-beverage
#20
REVIEW
Kassem Sharif, Abdulla Watad, Nicola Luigi Bragazzi, Mohammad Adawi, Howard Amital, Yehuda Shoenfeld
Coffee is one of the world's most consumed beverage. In the last decades, coffee consumption has attracted a huge body of research due to its impact on health. Recent scientific evidences showed that coffee intake could be associated with decreased mortality from cardiovascular and neurological diseases, diabetes type II, as well as from endometrial and liver cancer, among others. In this review, on the basis of available data in the literature, we aimed to investigate the association between coffee intake and its influence on the immune system and the insurgence of the most relevant autoimmune diseases...
May 4, 2017: Autoimmunity Reviews
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