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cancer coffee

Muhammad Torequl Islam, Shams Tabrez, Nasimudeen R Jabir, Murtaza Ali, Mohammad A Kamal, Lidiane da Silva Araujo, Jose Victor De Oliveira Santos, Ana Maria Oliveira Ferreira Da Mata, Rai Pablo Sousa De Aguiar, Ana Amelia de Carvalho Melo Cavalcante
The popular drink, coffee (Coffea arabica) is under the great attention of late because of its promising pharmacological potential. Caffeine (the major constituent of coffee) is known for its prominent psychoactive impact. This review aims at highlighting the therapeutic potentials of caffeine and other five coffee components viz. caffeic acid, chlorogenic acids, cafestol, ferulic acid and kahweol and their suggested mechanisms of action. A number of pharmacological activities are attributed to these components that include anti-oxidant, anti-inflammatory, immunomodulatory, anti-microbial, anti-cancer, cardioprotective and neuroprotective effects...
March 2, 2018: Current Drug Metabolism
Monika Gorzynik-Debicka, Paulina Przychodzen, Francesco Cappello, Alicja Kuban-Jankowska, Antonella Marino Gammazza, Narcyz Knap, Michal Wozniak, Magdalena Gorska-Ponikowska
Beneficial effects of natural plant polyphenols on the human body have been evaluated in a number of scientific research projects. Bioactive polyphenols are natural compounds of various chemical structures. Their sources are mostly fruits, vegetables, nuts and seeds, roots, bark, leaves of different plants, herbs, whole grain products, processed foods (dark chocolate), as well as tea, coffee, and red wine. Polyphenols are believed to reduce morbidity and/or slow down the development of cardiovascular and neurodegenerative diseases as well as cancer...
February 28, 2018: International Journal of Molecular Sciences
Alex O Okaru, Anke Rullmann, Adriana Farah, Elvira Gonzalez de Mejia, Mariana C Stern, Dirk W Lachenmeier
BACKGROUND: Consumption of very hot (> 65 °C) beverages is probably associated with increased risk of oesophageal cancer. First associations were reported for yerba mate and it was initially believed that high content of polycyclic aromatic hydrocarbons (PAH) might explain the risk. Later research on other beverage groups such as tea and coffee, which are also consumed very hot, found associations with increased risk of oesophageal cancer as well. The risk may therefore not be inherent in any compound contained in mate, but due to temperature...
March 1, 2018: BMC Cancer
Marko Lukic, Lena Maria Nilsson, Guri Skeie, Bernt Lindahl, Tonje Braaten
Studies on the association between heavy coffee consumption and risk of less frequently diagnosed cancers are scarce. We aimed to quantify the association between filtered, boiled, and total coffee consumption and the risk of bladder, esophageal, kidney, pancreatic, and stomach cancers. We used data from the Norwegian Women and Cancer Study and the Northern Sweden Health and Disease Study. Information on coffee consumption was available for 193,439 participants. We used multivariable Cox proportional hazards models to calculate hazard ratios (HR) with 95% confidence intervals (CI) for the investigated cancer sites by category of total, filtered, and boiled coffee consumption...
February 23, 2018: European Journal of Epidemiology
James H O'Keefe, James J DiNicolantonio, Carl J Lavie
Coffee, a complex brew containing hundreds of biologically active compounds, exerts potent effects on long-term human health. Recently, a plethora of studies have been published focusing on health outcomes associated with coffee intake. An inverse association between coffee consumption and all-cause mortality has been seen consistently in large prospective studies. Habitual coffee consumption is also associated with lower risks for cardiovascular (CV) death and a variety of adverse CV outcomes, including coronary heart disease (CHD), congestive heart failure (HF), and stroke; coffee's effects on arrhythmias and hypertension are neutral...
February 20, 2018: Progress in Cardiovascular Diseases
Ikuko Kashino, Shamima Akter, Tetsuya Mizoue, Norie Sawada, Ayaka Kotemori, Keitaro Matsuo, Isao Oze, Hidemi Ito, Mariko Naito, Tomio Nakayama, Yuri Kitamura, Akiko Tamakoshi, Ichiro Tsuji, Yumi Sugawara, Manami Inoue, Chisato Nagata, Atsuko Sadakane, Keitaro Tanaka, Shoichiro Tsugane, Taichi Shimazu
Coffee is a rich source of bioactive compounds that have potential anti-carcinogenic effects. However, it remains unclear whether coffee drinking is associated with colorectal cancer. Also, despite different etiological factors involved in gut physiology, few studies have investigated this association by anatomical site of the lesion. To address these issues, this study examined the association between coffee drinking and colorectal cancer in a pooled analysis from 8 cohort studies conducted in Japan. Among 320,322 participants followed up for 4,503,276 person-years, 6,711 incident colorectal cancer cases were identified...
February 15, 2018: International Journal of Cancer. Journal International du Cancer
Amanda J Cross, Marc J Gunter
No abstract text is available yet for this article.
February 6, 2018: Gastroenterology
Kazuo Yamagata
Epidemiologic studies from several countries have found that mortality rates associated with the metabolic syndrome are inversely associated with coffee consumption. Metabolic syndrome can lead to arteriosclerosis by endothelial dysfunction, and increases the risk for myocardial and cerebral infarction. Accordingly, it is important to understand the possible protective effects of coffee against components of the metabolic syndrome, including vascular endothelial function impairment, obesity and diabetes. Coffee contains many components, including caffeine, chlorogenic acid, diterpenes and trigonelline...
February 4, 2018: Antioxidants (Basel, Switzerland)
Piet A van den Brandt
Coffee and tea intake have been associated with reduced mortality, but no studies have investigated possible substitution effects. The relationship of mortality with coffee, tea, and substituting coffee with tea was investigated in the Netherlands Cohort Study. In 1986, 120,852 men and women aged 55-69 years provided information on dietary and lifestyle habits. Mortality follow-up until 1996 consisted of linkage to Statistics Netherlands. Multivariate case-cohort analyses were based on 8665 deaths and 3166 subcohort members with complete data on coffee, tea and confounders...
January 27, 2018: European Journal of Epidemiology
James M Cameron, Holly J Butler, David S Palmer, Matthew J Baker
The complex patterns observed from evaporated liquid drops have been examined extensively over the last 20 years. Complete understanding of drop deposition is vital in many medical processes, and one which is essential to the translation of biofluid spectroscopic disease diagnostics. The promising use of spectroscopy in disease diagnosis has been hindered by the complicated patterns left by dried biological fluids which may inhibit the clinical translation of this technology. Coffee-ring formation, cracking and gelation patterns have all been observed in biofluid drops, and with surface homogeneity being a key element to many spectroscopic techniques, experimental issues have been found to arise...
January 26, 2018: Journal of Biophotonics
Sobhy El-Sayed Hassab El-Nabi, Gouda T M Dawoud, Islam Mohamed El-Garawani, Samraa Samy El Shafey
Coffee is a popular drink; it is one of the most commercialized food products and a rich source of biologically active compounds that are important for human health. This study aimed to prove the anticancer activity of green coffee (GC) and roasted coffee (RC) bean aqueous extracts (Coffea arabica) on breast cancer adenocarcinoma cell line (MCF-7) and the safety of both extracts on normal human peripheral blood lymphocytes culture (HPBL). Total phenolic content for GC and RC extracts was measured and result of both extracts were (0...
January 24, 2018: Anti-cancer Agents in Medicinal Chemistry
Alessandra Lafranconi, Agnieszka Micek, Paolo De Paoli, Sabrina Bimonte, Paola Rossi, Vincenzo Quagliariello, Massimiliano Berretta
Aim: A dose-response meta-analysis was conducted in order to summarize the evidence from prospective cohort studies regarding the association between coffee intake and breast cancer risk. Methods: A systematic search was performed in electronic databases up to March 2017 to identify relevant studies; risk estimates were retrieved from the studies and linear and non-linear dose-response analysis modelled by restricted cubic splines was conducted. A stratified and subgroup analysis by menopausal and estrogen/progesterone receptor (ER/PR) status, smoking status and body mass index (BMI) were performed in order to detect potential confounders...
January 23, 2018: Nutrients
Lusine Yaghjyan, Graham Colditz, Bernard Rosner, Aleksandra Gasparova, Rulla M Tamimi
PURPOSE: Previous studies suggest that coffee and caffeine intake may be associated with reduced breast cancer risk. We investigated the association of coffee and caffeine intake with mammographic breast density by woman's menopausal status and, in postmenopausal women, by hormone therapy (HT). METHODS: This study included 4130 cancer-free women within the Nurses' Health Study and Nurses' Health Study II cohorts. Percent breast density (PD) was measured from digitized film mammograms using a computer-assisted thresholding technique and square root-transformed for the analysis...
January 17, 2018: Breast Cancer Research and Treatment
Ayaka Kotemori, Junko Ishihara, Ling Zha, Rong Liu, Norie Sawada, Motoki Iwasaki, Tomotaka Sobue, Shoichiro Tsugane
Acrylamide forms during cooking and is classified as a probable carcinogen in humans, mandating the need for epidemiological studies of dietary acrylamide and cancers. However, the risk of dietary acrylamide exposure to breast cancer in Japanese women has not been assessed. We investigated the association between dietary acrylamide intake and risk of breast cancer in the Japan Public Health Center-based Prospective Study. The present study included 48,910 women aged 45-74 years who responded to a 5-year follow-up survey questionnaire...
December 30, 2017: Cancer Science
Christian D Fankhauser, Hugh Mostafid
PURPOSE OF REVIEW: We review the influence of nutrition and lifestyle on bladder cancer incidence and recurrence and summarize food items, diets and lifestyle practices that physicians may wish to prioritize for discussion with their patients. RECENT FINDINGS: Recent study results suggest an association between bladder cancer incidence and several food items including meat, fruit, vegetables, milk products and oil. Micronutrient deficiency is associated with bladder cancer risk; however, it remains unclear if micronutrient supplementation can modify bladder cancer incidence...
January 2018: Current Opinion in Urology
Giorgio Ivan Russo, Daniele Campisi, Marina Di Mauro, Federica Regis, Giulio Reale, Marina Marranzano, Rosalia Ragusa, Tatiana Solinas, Massimo Madonia, Sebastiano Cimino, Giuseppe Morgia
Dietary polyphenols gained the interest of the scientific community due to their wide content in a variety of plant-derived foods and beverages commonly consumed, such as fruits, vegetables, coffee, tea, and cocoa . We aimed to investigate whether there was an association between dietary phenolic acid consumption and prostate cancer (PCa) in South Italy. We conducted a population-based case-control study from January 2015 to December 2016 in a single institution of the municipality of Catania, southern Italy (Registration number: 41/2015)...
December 5, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Jue-Sheng Ong, Liang-Dar Hwang, Gabriel Cuellar-Partida, Nicholas G Martin, Georgia Chenevix-Trench, Michael C J Quinn, Marilyn C Cornelis, Puya Gharahkhani, Penelope M Webb, Stuart MacGregor
Background: Coffee consumption has been shown to be associated with various health outcomes in observational studies. However, evidence for its association with epithelial ovarian cancer (EOC) is inconsistent and it is unclear whether these associations are causal. Methods: We used single nucleotide polymorphisms associated with (i) coffee and (ii) caffeine consumption to perform Mendelian randomization (MR) on EOC risk. We conducted a two-sample MR using genetic data on 44 062 individuals of European ancestry from the Ovarian Cancer Association Consortium (OCAC), and combined instrumental variable estimates using a Wald-type ratio estimator...
November 25, 2017: International Journal of Epidemiology
Tanja Frey, Elizabeth A Platz, Norma Kanarek, Gary Bradwin, Adrian S Dobs, Sabine Rohrmann
BACKGROUND: By modulating the levels of sex steroid hormones and sex hormone-binding globulin (SHBG), caffeine could be a factor in the development of several conditions in men, including prostate cancer. The aim of this study was to evaluate if caffeine consumption is associated with concentrations of sex steroid hormones and SHBG in men. METHODS: 1,410 men aged 20 + years who attended the morning examination session of the Third National Health and Nutrition Examination Survey (1988-1991) were included in the analysis...
January 2018: Cancer Causes & Control: CCC
Jie Shen, Yuanqing Ye, David W Chang, Maosheng Huang, John V Heymach, Jack A Roth, Xifeng Wu, Hua Zhao
OBJECTIVES: The prognosis for advanced-stage non-small cell lung cancer (NSCLC) is usually poor. However, survival may be variable and difficult to predict. In the current study, we aimed to identify circulating metabolites as potential predictive biomarkers for overall survival of advanced-stage (III/IV) NSCLC patients treated with first-line platinum-based chemotherapy. MATERIALS AND METHODS: Using two-stage study design, we performed global metabolomic profiling in blood of 220 advanced-stage NSCLC patients, including 110 with poor survival and 110 with good survival...
December 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
Robin Poole, Oliver J Kennedy, Paul Roderick, Jonathan A Fallowfield, Peter C Hayes, Julie Parkes
Objectives  To evaluate the existing evidence for associations between coffee consumption and multiple health outcomes. Design  Umbrella review of the evidence across meta-analyses of observational and interventional studies of coffee consumption and any health outcome. Data sources  PubMed, Embase, CINAHL, Cochrane Database of Systematic Reviews, and screening of references. Eligibility criteria for selecting studies  Meta-analyses of both observational and interventional studies that examined the associations between coffee consumption and any health outcome in any adult population in all countries and all settings...
November 22, 2017: BMJ: British Medical Journal
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