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https://www.readbyqxmd.com/read/28641285/role-of-glycyrrhizin-in-the-reduction-of-inflammation-in-diabetic-kidney-disease
#1
Vikram Thakur, Syeda Nargis, Mayra Gonzalez, Swetak Pradhan, Daniel Terreros, Munmun Chattopadhyay
BACKGROUND: Diabetic kidney disease (DKD) is one of the most debilitating complications of type 2 diabetes. Recent evidence suggests chronic inflammation to be one of the causal factors of DKD. The mechanisms entailed are not completely elucidated except that a variety of cytokines play a major role in this process. High mobility group box 1 (HMGB1) is a pro-inflammatory toll-like receptor-4 (TLR4)-binding cytokine that is involved in inflammation-associated gene expression. This investigation was designed to assess the involvement of HMGB1, TLR-4, and nuclear factor (NF)-κB in the development of DKD and to evaluate that whether blocking HMGB1 by its natural inhibitor Glycyrrhizin (GLC) can reduce the progression of the disease...
June 23, 2017: Nephron
https://www.readbyqxmd.com/read/28641252/an-embedded-marked-point-process-framework-for-three-level-object-population-analysis
#2
Csaba Benedek
In this paper we introduce a probabilistic approach for extracting complex hierarchical object structures from digital images used by various vision applications. The proposed framework extends conventional Marked Point Process (MPP) models by (i) admitting object-subobject ensembles in parent-child relationships and (ii) allowing corresponding objects to form coherent object groups, by a Bayesian segmentation of the population. Different from earlier, highly domain specific attempts on MPP generalization, the proposed model is defined at an abstract level, providing clear interfaces for applications in various domains...
June 15, 2017: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/28641237/tunable-excited-state-intramolecular-proton-transfer-reactions-with-nh-or-oh-as-a-proton-donor-a-theoretical-investigation
#3
Yuanyuan Li, Keke Wen, Songyan Feng, Huijuan Yuan, Beibei An, Qiuling Zhu, Xugeng Guo, Jinglai Zhang
Excited-state intramolecular proton transfer (ESIPT) reactions occurring in the S1 state for five molecules, which possess five/six-membered ring intramolecular NH···N or OH···N hydrogen bonds bearing quinoline or 2-phenylpyridine moiety, have been described in detail by the time-dependent density functional theory (TD-DFT) approach using the B3LYP hybrid functional. For the five molecules, the constrained potential energy profiles along the ESIPT reactions show that proton transfer is barrierless in molecules possessing six-membered ring intramolecular H-bonds, which is smoother than that with certain barriers in five-membered ring H-bonding systems...
June 15, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28641225/investigation-of-dissociation-constants-for-individual-and-total-naphthenic-acids-species-using-ultra-performance-liquid-chromatography-ion-mobility-time-of-flight-mass-spectrometry-analysis
#4
Rongfu Huang, Pamela Chelme-Ayala, Yanyan Zhang, Mohamed Changalov, Mohamed Gamal El-Din
Ultra-performance liquid chromatography ion mobility time-of-flight mass spectrometry (UPLC-IM-TOFMS) was utilized for the analysis of naphthenic acids (NAs) in fractions of pH-dependent sequential liquid-liquid extractions from oil sands process-affected water. Ion-mobility separation technique allowed the differentiation of OyS-NAs (2 ≤ y ≤ 4) from Ox-NAs (2 ≤ x ≤ 5) via drift time versus retention time separations. The results indicated that the addition of S atom to the O2-NA molecule led to a lower increase in the dissociation constant (pKa) compared to that caused by the addition of O atom...
June 18, 2017: Chemosphere
https://www.readbyqxmd.com/read/28641189/qualitative-and-quantitative-simulation-of-androgen-receptor-antagonists-a-case-study-of-polybrominated-diphenyl-ethers
#5
Yang Wu, Wei Shi, Pu Xia, Xiaowei Zhang, Hongxia Yu
Recently, great attention has been paid to the identification and prediction of the androgen disrupting potencies of polybrominated diphenyl ethers (PBDEs). However, few existing models can discriminate active and inactive compounds, which make the quantitative prediction process including the quantitative structure-activity relationship (QSAR) technique unreliable. In this study, different grouping methods were investigated and compared for qualitative identification, including molecular docking and molecular dynamics simulations (MD)...
June 19, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28641167/exploring-the-role-of-knowledge-of-condition-and-psycho-social-profiles-of-young-people-with-epilepsy-during-transition
#6
Victoria Gray, Lucy Palmer, Kayleigh Whelby, Jacqui Vinten, Lucy Gait
Transitioning from paediatric to adult care can be a particularly challenging time for young people with epilepsy and research has shown that there are a range of factors which may influence a young person's ability to successfully cope with this difficult time. The following study aimed to explore the psychosocial characteristics of this transitioning population, as well as investigate how knowledgeable the young person and their parent/carer are of their own condition throughout transition. Young people with epilepsy were recruited from two specialist epilepsy clinics in the North West and allocated to one of three groups; Group 1 pre-transition, Group 2 transitioning, and Group 3 post-transition...
June 19, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28641064/a-qualitative-evaluation-of-a-preventive-intervention-for-parents-the-groups-for-family-enrichment_parent-version-gfe_p
#7
Anna Bertoni, Silvia Donato, Antonella Morgano, Raffaella Iafrate, Rosa Rosnati
The traditional objective of parenting enrichment programs is to train parents' abilities and specific competences, but less attention is paid to promoting participants' reflection on their parental identity. These programs are generally delivered to groups of parents, though the group is rarely considered a specific tool to promote changes in participants' relational functioning. The Groups for Family Enrichment_Parent version (GFE_P; Iafrate, Donato, & Bertoni, 2010 ; Iafrate & Rosnati, 2007 ) focus on parental identity in addition to parental competences and skills and purposely use the group of parents as an educational tool, adopting a semistructured format...
July 2017: Journal of Prevention & Intervention in the Community
https://www.readbyqxmd.com/read/28641054/behavioural-interventions-to-reduce-nickel-exposure-in-a-nickel-processing-plant
#8
Krassi Rumchev, Helen Brown, Amanda Wheeler, Gavin Pereira, Jeff Spickett
Nickel is a widely used material in many industries. Although, there is enough evidence that occupational exposure to nickel may cause respiratory illnesses, allergies and even cancer, it is not possible to stop the use of nickel in occupational settings. Nickel exposure, however, can be controlled and reduced significantly in workplaces. The main objective of this study was to assess if educational intervention of hygiene behaviour could reduce nickel exposure among Indonesian nickel smelter workers. Participants were randomly assigned to three intervention groups (n = 99)...
June 22, 2017: Journal of Occupational and Environmental Hygiene
https://www.readbyqxmd.com/read/28641047/the-interaction-of-distress-tolerance-and-intolerance-of-uncertainty-in-the-prediction-of-symptom-reduction-across-cbt-for-social-anxiety-disorder
#9
Danielle Katz, Neil A Rector, Judith M Laposa
Distress tolerance (DT) and intolerance of uncertainty (IU) have been identified as transdiagnostic processes that predict symptom severity across a range of distinct anxiety disorders. However, the joint effect of these two variables on therapeutic outcome has not yet been examined. It is possible that DT and IU may both impact on treatment response to cognitive-behavioural therapy (CBT) in clients with anxiety, as clients with weak DT and strong IU may be less likely to engage in exposure and cognitive restructuring tasks across treatment due to their associated distress...
June 22, 2017: Cognitive Behaviour Therapy
https://www.readbyqxmd.com/read/28641016/from-hydrindane-to-decalin-a-mild-transformation-through-a-dyotropic-ring-expansion
#10
Hugo Santalla, Olalla Nieto Faza, Generosa Gómez, Yagamare Fall, Carlos Silva López
An unexpected ring expansion converting hydrindane cores into decalins has been observed. The process occurs under very mild conditions and with exquisite transfer of chiral information. The ring expansion provides access to decorated decalins with complete stereocontrol. The reaction mechanism is studied in order to gain insight into the underlying causes for the low thermal requirements in this reaction and the nature of the chirality transfer process. Interestingly, both result from an unprecedented dyotropic reaction involving a mesylate group...
June 22, 2017: Organic Letters
https://www.readbyqxmd.com/read/28640998/oximes-and-hydrazones-in-bioconjugation-mechanism-and-catalysis
#11
Dominik K Kölmel, Eric T Kool
The formation of oximes and hydrazones is employed in numerous scientific fields as a simple and versatile conjugation strategy. This imine-forming reaction is applied in fields as diverse as polymer chemistry, biomaterials and hydrogels, dynamic combinatorial chemistry, organic synthesis, and chemical biology. Here we outline chemical developments in this field, with special focus on the past ∼10 years of developments. Recent strategies for installing reactive carbonyl groups and α-nucleophiles into biomolecules are described...
June 22, 2017: Chemical Reviews
https://www.readbyqxmd.com/read/28640989/stimulant-treatment-trajectories-are-associated-with-neural-reward-processing-in-attention-deficit-hyperactivity-disorder
#12
Lizanne J S Schweren, Annabeth Groenman, Daniel von Rhein, Wouter Weeda, Stephen F Faraone, Marjolein Luman, Hanneke van Ewijk, Dirk J Heslenfeld, Barbara Franke, Jan K Buitelaar, Jaap Oosterlaan, Pieter J Hoekstra, Catharina A Hartman
OBJECTIVE: The past decades have seen a surge in stimulant prescriptions for the treatment of attention-deficit/hyperactivity disorder (ADHD). Stimulants acutely alleviate symptoms and cognitive deficits associated with ADHD by modulating striatal dopamine neurotransmission and induce therapeutic changes in brain activation patterns. Long-term functional changes after treatment are unknown, as long-term studies are scarce and have focused on brain structure. In this observational study (2009-2012), we investigated associations between lifetime stimulant treatment history and neural activity during reward processing...
June 20, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28640940/regioselective-direct-c-alkenylation-of-indoles
#13
Marino Petrini
The direct introduction of alkenyl groups into the indole framework avoiding its preliminary functionalization can be carried out using different synthetic strategies. Transition metal complexes facilitate the C-H activation of indoles or alkenes allowing an efficient Csp2- Csp2 bond formation. The hydroindolation of alkynes catalyzed by the same metal complexes or various acidic promoters can also be pursued for the alkenylation process. Conjugate addition of electron-poor alkenes and direct condensation of carbonyl derivative with indoles are also of interest for this purpose...
June 22, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28640919/the-measles-epidemic-trend-over-the-past-30-years-in-a-central-district-in-shanghai-china
#14
Jie Gao, Bing Shen, JianJing Xiong, Yihan Lu, Qingwu Jiang
BACKGROUND: Measles vaccination over the past 50 years has greatly reduced the incidence of measles. However, measles among migrants and the resulting changes in epidemiological characteristics have brought new challenges to the elimination of measles. We aim to describe the measles epidemic trend over the past 30 years in a central district in Shanghai, China. METHODS: The present study was conducted in the Jing'an District, which is located in the center of Shanghai...
2017: PloS One
https://www.readbyqxmd.com/read/28640899/normative-3d-opto-electronic-stereo-photogrammetric-posture-and-spine-morphology-data-in-young-healthy-adult-population
#15
Moreno D'Amico, Edyta Kinel, Piero Roncoletta
Observational cross-sectional study. The current study aims to yield normative data: i.e., the physiological standard for 30 selected quantitative 3D parameters that accurately capture and describe a full-skeleton, upright-standing attitude. Specific and exclusive consideration was given to three distinct categories: postural, spine morphology and pelvic parameters. To capture such 3D parameters, the authors selected a non-ionising 3D opto-electronic stereo-photogrammetric approach. This required the identification and measurement of 27 body landmarks, each specifically tagged with a skin marker...
2017: PloS One
https://www.readbyqxmd.com/read/28640834/overexpression-of-gmfdl19-enhances-tolerance-to-drought-and-salt-stresses-in-soybean
#16
Yuanyuan Li, Quanzhen Chen, Haiyang Nan, Xiaoming Li, Sijia Lu, Xiaohui Zhao, Baohui Liu, Changhong Guo, Fanjiang Kong, Dong Cao
The basic leucine zipper (bZIP) family of transcription factors plays an important role in the growth and developmental process as well as responds to various abiotic stresses, such as drought and high salinity. Our previous work identified GmFDL19, a bZIP transcription factor, as a flowering promoter in soybean, and the overexpression of GmFDL19 caused early flowering in transgenic soybean plants. Here, we report that GmFDL19 also enhances tolerance to drought and salt stress in soybean. GmFDL19 was determined to be a group A member, and its transcription expression was highly induced by abscisic acid (ABA), polyethylene glycol (PEG 6000) and high salt stresses...
2017: PloS One
https://www.readbyqxmd.com/read/28640802/peroxisomal-biogenesis-is-genetically-and-biochemically-linked-to-carbohydrate-metabolism-in-drosophila-and-mouse
#17
Michael F Wangler, Yu-Hsin Chao, Vafa Bayat, Nikolaos Giagtzoglou, Abhijit Babaji Shinde, Nagireddy Putluri, Cristian Coarfa, Taraka Donti, Brett H Graham, Joseph E Faust, James A McNew, Ann Moser, Marco Sardiello, Myriam Baes, Hugo J Bellen
Peroxisome biogenesis disorders (PBD) are a group of multi-system human diseases due to mutations in the PEX genes that are responsible for peroxisome assembly and function. These disorders lead to global defects in peroxisomal function and result in severe brain, liver, bone and kidney disease. In order to study their pathogenesis we undertook a systematic genetic and biochemical study of Drosophila pex16 and pex2 mutants. These mutants are short-lived with defects in locomotion and activity. Moreover these mutants exhibit severe morphologic and functional peroxisomal defects...
June 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28640659/phlda1-pleckstrin-homology-like-domain-family-a-member-1-knockdown-promotes-migration-and-invasion-of-mcf10a-breast-epithelial-cells
#18
Naieli Bonatto, Maria José Carlini, Simone Aparecida de Bessa Garcia, Maria Aparecida Nagai
PHLDA1 (pleckstrin homology-like domain, family A, member 1) is a multifunctional protein that plays distinct roles in several biological processes including cell death and therefore its altered expression has been identified in different types of cancer. Progressively loss of PHLDA1 was found in primary and metastatic melanoma while its overexpression was reported in intestinal and pancreatic tumors. Previous work from our group showed that negative expression of PHLDA1 protein was a strong predictor of poor prognosis for breast cancer disease...
June 22, 2017: Cell Adhesion & Migration
https://www.readbyqxmd.com/read/28640639/alkaline-earth-centered-co-homologation-reduction-and-amine-carbonylation
#19
Mathew D Anker, Christos E Kefalidis, Yan Yang, Jian Fang, Michael S Hill, Mary F Mahon, Laurent Maron
Reactions of -diketiminato magnesium and calcium hydrides with 1 atmosphere of CO result in a reductive coupling process to produce the corresponding derivatives of the cis-ethenediolate dianion. Computational (DFT) analysis of this processes mediated by Ca, Sr and Ba highlight a common mechanism and a facility for the reaction that increases with increasing alkaline earth (Ae) atomic weight. Reaction of CO with PhSiH3 in the presence of the magnesium or calcium hydrides results in catalytic reduction to methylsilane and methylene silylether products respectively...
June 22, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28637243/nanopore-sequencing-data-analysis-state-of-the-art-applications-and-challenges
#20
Alberto Magi, Roberto Semeraro, Alessandra Mingrino, Betti Giusti, Romina D'Aurizio
The nanopore sequencing process is based on the transit of a DNA molecule through a nanoscopic pore, and since the 90s is considered as one of the most promising approaches to detect polymeric molecules. In 2014, Oxford Nanopore Technologies (ONT) launched a beta-testing program that supplied the scientific community with the first prototype of a nanopore sequencer: the MinION. Thanks to this program, several research groups had the opportunity to evaluate the performance of this novel instrument and develop novel computational approaches for analyzing this new generation of data...
June 16, 2017: Briefings in Bioinformatics
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