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https://www.readbyqxmd.com/read/29454294/parents-and-early-adolescents-self-efficacy-about-anger-regulation-and-early-adolescents-internalizing-and-externalizing-problems-a-longitudinal-study-in-three-countries
#1
Laura Di Giunta, Anne-Marie R Iselin, Jennifer E Lansford, Nancy Eisenberg, Carolina Lunetti, Eriona Thartori, Emanuele Basili, Concetta Pastorelli, Dario Bacchini, Liliana Maria Uribe Tirado, Maria Gerbino
The present study examines whether early adolescents' self-efficacy beliefs about anger regulation mediate the relation between parents' self-efficacy beliefs about anger regulation and early adolescents' internalizing and externalizing problems. Participants were 534 early adolescents (T1: M age = 10.89, SD = .70; 50% female), their mothers (n = 534), and their fathers (n = 431). Families were drawn from Colombia, Italy, and the USA. Follow-up data were obtained two (T2) and three (T3) years later. At T1 and T3, parents' self-efficacy beliefs were self-reported and internalizing and externalizing problems were assessed via mothers', fathers', and early adolescents' reports...
February 14, 2018: Journal of Adolescence
https://www.readbyqxmd.com/read/29454237/liposomes-of-dimeric-artesunate-phospholipid-a-combination-of-dimerization-and-self-assembly-to-combat-malaria
#2
Muhammad Ismail, Longbing Ling, Yawei Du, Chen Yao, Xinsong Li
Artemisinin and its derivatives are highly effective drugs in the treatment of P. falciparum malaria. However, their clinical applications face challenges because of short half-life, poor bioavailability and growing drug resistance. In this article, novel dimeric artesunate phospholipid (Di-ART-GPC) based liposomes were developed by combination of dimerization and self-assembly to address these shortcomings. Firstly, Di-ART-GPC conjugate was synthesized by a facile esterification of artesunate (ART) and glycerophosphorylcholine (GPC) and confirmed by MS, 1 H NMR and 13 C NMR...
February 10, 2018: Biomaterials
https://www.readbyqxmd.com/read/29454236/stingel-controlled-release-of-a-cyclic-dinucleotide-for-enhanced-cancer-immunotherapy
#3
David G Leach, Neeraja Dharmaraj, Stacey L Piotrowski, Tania L Lopez-Silva, Yu L Lei, Andrew G Sikora, Simon Young, Jeffrey D Hartgerink
Recent advancements in the field of immunotherapy have yielded encouraging results for the treatment of advanced cancers. Cyclic dinucleotides (CDNs) are a powerful new class of immunotherapy drugs known as STING (Stimulator of Interferon Genes) agonists, currently in clinical trials. However, previous studies of CDNs in murine cancer models have required multiple injections, and improve survival only in relatively nonaggressive tumor models. Therefore, we sought to improve the efficacy of CDN immunotherapy by developing a novel biomaterial we call "STINGel...
February 6, 2018: Biomaterials
https://www.readbyqxmd.com/read/29454231/influence-of-heading-perception-in-the-control-of-posture
#4
Alessandro Piras, Milena Raffi, Monica Perazzolo, Salvatore Squatrito
The optic flow visual input directly influences the postural control. The aim of the present study was to examine the relationship between visually induced heading perception and postural stability, using optic flow stimulation. The dots were accelerated to simulate a heading direction to the left or to the right of the vertical midline. The participants were instructed to indicate the perceived optic flow direction by making a saccade to the simulated heading direction. We simultaneously acquired electromyographyc and center of pressure (COP) signals...
February 10, 2018: Journal of Electromyography and Kinesiology
https://www.readbyqxmd.com/read/29454182/the-positive-effect-of-venlafaxine-on-central-motor-conduction
#5
Chunyong Li, Fuda Liu, Haiyan Peng, Yongjun Huang, Xuezhu Song, Qi Xie, Yingkai Li, Yan Liu
OBJECTIVES: Using the triple stimulation technique (TST) and conventional transcranial magnetic stimulation (TMS), this study was designed to investigate the effect of venlafaxine on central motor conduction in healthy adults. PATIENTS AND METHODS: In this crossover, self-controlled trial, eight healthy adult volunteers were randomly divided into groups A and B. In group A, the volunteers were administered 1 venlafaxine capsule once daily for 7 consecutive days, followed by a 3-day break...
February 12, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29454176/efficacy-of-intensive-voice-feminisation-therapy-in-a-transgender-young-offender
#6
Sterling Quinn, Nathaniel Swain
Research suggests that transgender young offenders are a uniquely vulnerable caseload that may benefit from speech pathology intervention to help bring their voice into alignment with their gender identity. However, no previous studies have investigated treatment efficacy in this population. This study investigated the impact of intensive voice feminisation therapy targeting fundamental frequency and oral resonance in a 17 year old transgender individual within a youth justice institution. Acoustic analysis, listener and self-ratings of vocal femininity, self-ratings of vocal satisfaction, a post-treatment structured interview, and pre- and post- treatment completion of the Transsexual Voice Questionnaire (TVQ MtF ) were utilised to determine treatment impact...
February 8, 2018: Journal of Communication Disorders
https://www.readbyqxmd.com/read/29454164/self-reported-inhibition-predicts-history-of-suicide-attempts-in-bipolar-disorder-and-major-depression
#7
André Ponsoni, Laura Damiani Branco, Charles Cotrena, Flávio Milman Shansis, Rodrigo Grassi-Oliveira, Rochele Paz Fonseca
BACKGROUND: Studies have reliably identified an association between suicide attempts and executive functions such as decision making (DM) and inhibitory control (IC) in patients with mood disorders. As such, the present study aimed to investigate the association between inhibition, DM, impulsivity and the history of suicide attempts in individuals with bipolar (BD) or major depressive disorder (MDD), identifying which assessment instruments may be most strongly associated with suicide in clinical samples...
February 14, 2018: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/29454131/self-reported-headaches-in-patients-with-unruptured-intracranial-aneurysms-treated-with-the-pipeline-embolization-device
#8
Anna M Schneider, Justin M Moore, Nimer Adeeb, Raghav Gupta, Christoph J Griessenauer, Peter A Winkler, Sarah Sieber, Abdulrahman Y Alturki, Christopher S Ogilvy, Ajith J Thomas
INTRODUCTION: The objective of this study was to analyze patients' perceptions of their headaches both prior to and following Pipeline flow diversion treatment of their unruptured intracranial aneurysms, with the goal of identifying prognostic factors associated with headache patterns to improve predictions of overall outcomes. MATERIALS AND METHODS: We retrospectively identified 133 patients treated with the PED between January 1 st 2014 and December 31 st 2016 at an academic institution in the United States...
February 14, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29454084/augmented-voluntary-consumption-of-ethanol-induced-by-reward-downshift-increases-locomotor-activity-of-male-wistar-rats-in-the-elevated-plus-maze
#9
Rocio Donaire, Shannon E Conrad, Joanna B Thompson, Mauricio R Papini, Carmen Torres
Rats exposed to unexpected reward loss increase voluntary oral consumption of ethanol. Such consumption has been assumed to attenuate loss-induced negative affect (called emotional self-medication). To test this assumption, food-deprived male Wistar rats were exposed to 10 sessions of access to 32% sucrose followed by 5 sessions of access to 4% sucrose (reward downshift). A two-bottle preference test was initiated immediately after each consummatory session to assess ethanol intake. The experimental group received access to 2% ethanol and water, whereas the control group received access to two water bottles...
February 14, 2018: Behavioural Processes
https://www.readbyqxmd.com/read/29454078/looking-for-capacities-rather-than-vulnerabilities-the-moderating-effect-of-health-assets-on-the-associations-between-adverse-social-position-and-health
#10
Mathieu Roy, Mélanie Levasseur, Isabelle Doré, France St-Hilaire, Bernard Michallet, Yves Couturier, Danielle Maltais, Bengt Lindström, Mélissa Généreux
To increase capacities and control over health, it is necessary to foster assets (i.e. factors enhancing abilities of individuals or communities). Acting as a buffer, assets build foundations for overcoming adverse conditions and improving health. However, little is known about the distribution of assets and their associations with social position and health. In this study, we documented the distribution of health assets and examined whether these assets moderate associations between adverse social position and self-reported health...
February 14, 2018: Preventive Medicine
https://www.readbyqxmd.com/read/29454064/rna-based-micelles-a-novel-platform-for-chemotherapeutic-drug-loading-and-delivery
#11
Yi Shu, Hongran Yin, Mehdi Rajabi, Hui Li, Mario Vieweger, Sijin Guo, Dan Shu, Peixuan Guo
RNA can serve as powerful building blocks for bottom-up fabrication of nanostructures for biotechnological and biomedical applications. In addition to current self-assembly strategies utilizing base pairing, motif piling and tertiary interactions, we reported for the first time to build RNA based micellar nanoconstruct with a cholesterol molecule conjugated onto one helical end of a branched pRNA three-way junction (3WJ) motif. The resulting amphiphilic RNA micelles consist of a hydrophilic RNA head and a covalently linked hydrophobic lipid tail that can spontaneously assemble in aqueous solution via hydrophobic interaction...
February 14, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29454054/genomic-perspectives-of-spider-silk-genes-through-target-capture-sequencing-conservation-of-stabilization-mechanisms-and-homology-based-structural-models-of-spidroin-terminal-regions
#12
Matthew A Collin, Thomas H Clarke, Nadia A Ayoub, Cheryl Y Hayashi
A powerful system for studying protein aggregation, particularly rapid self-assembly, is spider silk. Spider silks are proteinaceous and silk proteins are synthesized and stored within silk glands as liquid dope. As needed, liquid dope is near-instantaneously transformed into solid fibers or viscous adhesives. The dominant constituents of silks are spidroins (spider fibroins) and their terminal domains are vital for the tight control of silk self-assembly. To better understand spidroin termini, we used target capture and deep sequencing to identify spidroin gene sequences from six species representing the araneoid families of Araneidae, Nephilidae, and Theridiidae...
February 14, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29454035/high-and-low-doses-of-cocaine-intake-are-differentially-regulated-by-dopamine-d2-receptors-in-the-ventral-tegmental-area-and-the-nucleus-accumbens
#13
R Chen, S McIntosh, S E Hemby, H Sun, T Sexton, Thomas Martin, S R Childers
Dopamine D2 receptors (D2Rs) in the ventral tegmental area (VTA) and the nucleus accumbens (NAc) are associated with vulnerability to addiction; however, whether D2Rs in these two brain regions play differential roles in regulation of drug intake is unknown. Here, we compared the effect of decreased mRNA level of Drd2 in each region on cocaine self-administration in a dose-response function. Drd2 mRNA levels in rat VTA or NAc were knocked down by bilateral microinjection of lentivirus coding shRNAs against rat Drd2...
February 14, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29453965/effects-of-beauveria-bassiana-on-predation-and-behavior-of-the-predatory-mite-phytoseiulus-persimilis
#14
Shengyong Wu, Zhenlong Xing, Weinan Sun, Xuenong Xu, Ruixia Meng, Zhongren Lei
Determination of intraguild interactions between entomopathogens and predators is important when attempting to use a combination of these two natural enemy groups for biological control of their shared arthropod pest species. This study assessed the effects of Beauveria bassiana on the predation and associated behavior of the predatory mite, Phytoseiulus persimilis, against Tetranychus urticae. The functional response tests showed that P. persimilis exhibited a Holling type II response on the spider mite, Tetranychus urticae, when treated with either a B...
February 14, 2018: Journal of Invertebrate Pathology
https://www.readbyqxmd.com/read/29453904/synthesis-self-assembly-and-photoresponsive-liquid-crystals-based-on-azobenzene-derivatives
#15
Hongyan Wang, Yi Han, Wei Yuan, Mengjiao Wu, Yulan Chen
A new class of rod-coil-rod molecules with an azobenzene core were synthesized. They were found to form robust organogels in several kinds of organic solvents. Scanning electron microscopy (SEM), transmission electron microscopy (TEM), atomic force microscopy (AFM), FT-IR spectroscopy, UV-vis absorption spectroscopy, 1H NMR, and X-ray diffraction (XRD) revealed that in these organogels, the molecules self-assembled into nanofiber network with an H-type aggregation mode under the joint effect of Pi-Pi stacking, intermolecular hydrogen bonding, and van der Waals forces...
February 17, 2018: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/29453846/fabrication-of-miniature-elastomer-lenses-with-programmable-liquid-mold-for-smartphone-microscopy-curing-polydimethylsiloxane-with-in-situ-curvature-control
#16
Bhuvaneshwari Karunakaran, Joseph Tharion, Arvind Ramrao Dhawangale, Debjani Paul, Soumyo Mukherji
Miniature lenses can transform commercial imaging systems, e.g., smartphones and webcams, into powerful, low-cost, handheld microscopes. To date, the reproducible fabrication of polymer lenses is still a challenge as they require controlled dispensing of viscous liquid. This paper reports a reproducible lens fabrication technique using liquid mold with programmable curvature and off-the-shelf materials. The lens curvature is controlled during fabrication by tuning the curvature of an interface of two immiscible liquids [polydimethylsiloxane (PDMS) and glycerol]...
February 2018: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/29453838/from-cba-to-precautionary-appraisal-practical-responses-to-intractable-problems
#17
Andrew Stirling, Josie Coburn
The purpose of this essay is to critically review the design of methods for ethically robust forms of technology appraisal in the regulation of research and innovation in synthetic biology. It will focus, in particular, on the extent to which cost-benefit analysis offers a basis for informing decisions about which technological pathways to pursue and which to discourage. A further goal is to consider what (if anything) the precautionary principle might offer in enabling better decisions. And this, in turn, raises questions about why mention of precaution can excite accusations of unscientific bias or irrational, "anti-innovation" extremism...
January 2018: Hastings Center Report
https://www.readbyqxmd.com/read/29453834/demystifying-evidence-based-policy-analysis-by-revealing-hidden-value-laden-constraints
#18
Adam M Finkel
Consider any choice that affects some social policy. A decision that considers evidence will, at its heart, contain some kind of explicit or implicit "because" statement: "We are doing X because the evidence says Y." But can evidence ever truly speak for itself, in the sense of being reducible to objective utterances that are either correct or in need of correction? Before answering, consider what you'd prefer. Would you rather receive evidence that was free of any value judgments imposed by human actors, that was laden with value judgments that you agree with, or laden with value judgments that you disagree with? The central assertion of this essay is that, throughout policy analysis but especially in assessments of the costs and benefits of regulating versus encouraging new technologies (cost-benefit analysis, or CBA), the first possibility above is a mirage, and the second and third are self-contradictory...
January 2018: Hastings Center Report
https://www.readbyqxmd.com/read/29453793/cross-cultural-comparison-of-predictors-for-self-care-behaviors-in-patients-with-type-2-diabetes
#19
Kaori Ikeda, Shimpei Fujimoto, Beth Morling, Shiho Ayano-Takahara, Shin-Ichi Harashima, Yukiko Uchida, Nobuya Inagaki
The aim of this study is to evaluate how culture moderates the behavioral and psychosocial predictors of diabetes self-care activities. Patients with type 2 diabetes were recruited in the outpatient department at two sites: Kyoto University hospital in Japan and the Christiana Care Health System in the United States. The data was collected by survey using questionnaires including questions on the frequency of self-care activities, behavioral and psychosocial predictors, and other background information from 149 Japanese patients and 48 American patients...
February 17, 2018: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/29453786/long-term-outcomes-of-6-mm-diameter-of-fully-covered-self-expandable-metal-stents-in-benign-refractory-pancreatic-ductal-stricture
#20
Dongwook Oh, Jae Hoon Lee, Tae Jun Song, Do Hyun Park, Sung Koo Lee, Myung-Hwan Kim, Sang Soo Lee
OBJECTIVES: Fully covered self-expandable metal stents (FCSEMSs) placement has been tried for pancreatic ductal strictures in chronic pancreatitis. However, the long-term outcome of this procedure remains unknown. This study aimed to investigate the procedural and long-term outcomes of FCSEMS placement in patients with benign refractory pancreatic ductal strictures. METHODS: Between August 2011 and September 2015, 18 patients underwent endoscopic treatment with FCSEMSs for a benign refractory pancreatic ductal stricture...
February 17, 2018: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
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