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https://www.readbyqxmd.com/read/29679933/slip-avoidance-strategies-in-children-with-bilateral-spastic-cerebral-palsy-and-crouch-gait
#1
Ana Francisca Rozin Kleiner, Ilaria Pacifici, Claudia Condoluci, Chiarella Sforza, Manuela Galli
BACKGROUND: A slip occurs when the required friction (RCOF) to prevent slipping at the foot/floor interfaces exceeds the available friction. The RCOF is dependent upon the biomechanics features of individuals and their gait. On the other hand, the available friction depends on environmental features. Once individuals with crouch gait have their biomechanics of gait completely altered, how do they interact with a supporting surface? The aim was to quantify the RCOF in children with bilateral spastic cerebral palsy (BSCP) and crouch gait...
April 11, 2018: Clinical Biomechanics
https://www.readbyqxmd.com/read/29679897/the-role-of-eveningness-in-obsessive-compulsive-symptoms-cross-sectional-and-prospective-approaches
#2
Rebecca C Cox, Breanna Tuck, Bunmi O Olatunji
BACKGROUND: Eveningness may be defined as the tendency to be most active and alert during the evening. Previous research has linked eveningness with maladaptive psychological outcomes, and recent evidence has highlighted circadian dysregulation as a novel factor in psychopathology, including obsessive-compulsive disorder (OCD). However, limited research has examined the unique relationship between eveningness and OC symptoms. Two studies were conducted to thoroughly examine the links between eveningness and OC symptoms, while also considering the role of depression symptoms and sleep-related factors...
April 6, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29679896/treatment-as-usual-tau-as-a-control-condition-in-trials-of-cognitive-behavioural-based-psychotherapy-for-self-harm-impact-of-content-and-quality-on-outcomes-in-a-systematic-review
#3
REVIEW
Katrina Witt, Daniela Pache de Moraes, Tatiana Taylor Salisbury, Ella Aren S Man, David Gunnell, Philip Hazell, Ellen Townsend, Kees van Heeringen, Keith Hawton
BACKGROUND: Randomized controlled trials (RCTs) are the mainstay of evaluations of the efficacy of psychosocial interventions. In a recent Cochrane systematic review we analysed the efficacy of cognitive behavioural-based psychotherapies compared to treatment as usual (TAU) in adults who self-harm. In this study we examine the content and reporting quality of TAU in these trials and their relationship to outcomes. METHODS: Five electronic databases (CCDANCTR-Studies and References, CENTRAL, MEDLINE, EMBASE, and PsycINFO) were searched for RCTs, indexed between 1 January 1998 and 30 April 2015, of cognitive-behavioural interventions compared to TAU for adults following a recent (within six months) episode of self-harm...
April 4, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29679885/the-influence-of-religious-concepts-on-the-effects-of-blame-appraisals-on-negative-emotions
#4
Eddie M W Tong, Alan Q H Teo
This research examined the regulatory effects of religious concepts on appraisal-emotion processes, focusing on concepts related to God and the relationships between blame appraisals and anger and guilt. In two experimental studies (Studies 1 and 2), blame appraisals were manipulated while participants were exposed to a God or neutral prime, in the context of a failed laboratory task. In an event-sampling study (Study 3), daily blame appraisals and emotions were measured repeatedly in naturalistic environments and their relationships under high perceived moral unacceptability were examined in relation to participants' the tendency to focus on God (God-focus)...
April 18, 2018: Cognition
https://www.readbyqxmd.com/read/29679873/disentangling-the-mental-health-impact-of-childhood-abuse-and-neglect-a-replication-and-extension-study-in-a-brazilian-sample-of-high-risk-youth
#5
Irismar Reis de Oliveira, Ana Cristina Matos-Ragazzo, Yuning Zhang, Nina Maia Vasconcelos, Michella Lopes Velasquez, Daniela Reis, Monica Gonçalves Ribeiro, Marina Monzani da Rocha, Maria Conceição Rosario, Paul Stallard, Charlotte A M Cecil
Childhood maltreatment is a key predictor of mental health problems across the life span. Yet, how maltreatment types independently and jointly influence the risk for psychiatric problems remains unclear. The aim of the study was two-fold: first, to replicate recent findings regarding the impact of maltreatment types on youth psychiatric symptoms, based on a Brazilian sample of high-risk adolescents (n = 347; age range = 11-17 yrs), and second, to extend existing findings by examining whether this relationship is mediated by bullying victimization and/or perpetration...
April 18, 2018: Child Abuse & Neglect
https://www.readbyqxmd.com/read/29679863/discovery-of-new-gyrase-%C3%AE-inhibitors-via-structure-based-modeling
#6
Afaf H Al-Nadaf, Sajeda A Salah, Mutasem O Taha
Gyrase B is an essential enzyme in the prokaryotes which became an attractive target for antibacterial agents. In our study, we implemented a wide range of docking configurations to dock 120 inhibitors into the in the ATP- binding pocket of Gyrase B enzyme (PDB code: 4GEE). LigandFit docking engines and six scoring functions were utilized in the study. Furthermore, the ligands were docked in their ionized and unionized forms into the hydrous and anhydrous binding pocket. We used docking-based Comparative Intermolecular Contacts Analysis (db-CICA) which is a novel methodology to validate and identify the optimal docking configurations...
March 19, 2018: Computational Biology and Chemistry
https://www.readbyqxmd.com/read/29679862/a-small-scale-study-investigating-staff-and-student-perceptions-of-the-barriers-to-a-preventative-approach-for-adolescent-self-harm-in-secondary-schools-in-wales-a-grounded-theory-model-of-stigma
#7
Rachel Parker
OBJECTIVES: Grounded theory analysis of secondary school staff and pupil perceptions about the barriers to preventative work for adolescent self-harm within the secondary school setting in Wales. STUDY DESIGN: Qualitative and grounded theory. METHODS: Two secondary schools in Wales were purposefully sampled for variation. Four group interviews took place using qualitative research methods (Participatory Rapid Appraisal) with six school-based professionals and six students aged more than 16 years...
April 18, 2018: Public Health
https://www.readbyqxmd.com/read/29679850/non-suicidal-self-injury-in-patients-with-eating-disorders-prevalence-forms-functions-and-body-image-correlates
#8
Sandra Pérez, Jos H Marco, Montse Cañabate
INTRODUCTION: More than one third of patients with eating disorders report NSSI. Moreover, negative attitudes and feelings toward the body, body dissatisfaction, and body image disturbances have been linked to NSSI in community and clinical samples. However, there is a lack of studies exploring NSSI frequency and functions and the specific relationship between multidimensional body image dimensions and NSSI in eating disorder patients. OBJECTIVES: First, we explored the frequency, types, and functions of NSSI in a sample of 226 Spanish female participants with eating disorders (ED)...
April 12, 2018: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/29679795/self-controlled-release-of-oxaliplatin-prodrug-from-d-%C3%AE-tocopheryl-polyethylene-glycol-1000-succinate-tpgs-functionalized-mesoporous-silica-nanoparticles-for-cancer-therapy
#9
Chaoyu Liang, Heping Wang, Min Zhang, Wei Cheng, Zihuang Li, Junpeng Nie, Gan Liu, Daizheng Lian, Zhenhua Xie, Laiqiang Huang, Xiaowei Zeng
Oxaliplatin is a promising antitumor drug, but its effectiveness is limited by its side effects in vivo. In this study, we introduced an Oxaliplatin prodrug (Oxa(IV)) self-controlled release strategy, in which Oxa(IV) is encapsulated by TPGS functionalized mesoporous silica nanoparticles (MSNs), and its release is controlled by biological stimuli, such as acidic environments in tumor tissue and high concentrations of reductants in cancer cells. Despite the lack of auxiliary "gatekeepers" to MSNs, this simplified model of Oxa(IV)-MSNs-TPGS could fine-tune the movements of the drug release...
April 16, 2018: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29679793/self-stigma-in-ptsd-prevalence-and-correlates
#10
Kelsey A Bonfils, Paul H Lysaker, Philip T Yanos, Alysia Siegel, Bethany L Leonhardt, Alison V James, Beth Brustuen, Brandi Luedtke, Louanne W Davis
Self-stigma is the internalization of negative societal stereotypes about those with mental illnesses. While self-stigma has been carefully characterized in severe mental disorders, like schizophrenia, the field has yet to examine the prevalence and correlates of self-stigma in post-traumatic stress disorder (PTSD). Thus, we assessed self-stigma in veterans diagnosed with PTSD and compared with veterans with schizophrenia. We further examined associations between PTSD, depressive symptoms and self-stigma in the PTSD sample...
April 3, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29679792/metacognitive-self-reflectivity-moderates-the-relationship-between-distress-tolerance-and-empathy-in-schizophrenia
#11
Kelsey A Bonfils, Kyle S Minor, Bethany L Leonhardt, Paul H Lysaker
Deficits in empathy seen in schizophrenia are thought to play a major role in the social dysfunction seen in the disorder. However, little work has investigated potential determinants of empathic deficits. This study aimed to fill that gap by examining the effects of two variables on empathy - distress tolerance and metacognitive self-reflectivity. Fifty-four people with schizophrenia-spectrum disorders receiving services at an urban VA or community mental health center were assessed for empathy, metacognition, and distress tolerance...
April 13, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29679673/glycogen-based-self-healing-hydrogels-with-ultra-stretchable-flexible-and-enhanced-mechanical-properties-via-sacrificial-bond-interactions
#12
Imtiaz Hussain, Sayed Mir Sayed, Shunli Liu, Olayinka Oderinde, Fang Yao, Guodong Fu
The development of hydrogel materials with enhanced mechanical properties is the primary focus in designing autonomous self-healable hydrogel materials. Here, we present a facile and cost-effective method for the autonomous self-healing hydrogel based on Glycogen (Gly/PAA-Fe3+ ) with enhanced mechanical properties by simple insertion of ferric ions in the physically cross-linked network via metal-ligand interactions. This dual physically cross-linked hydrogel has an excellent elongation at break and self-healing properties due to the dynamic ionic cross-linking point...
April 18, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29679604/outdoor-play-and-nature-connectedness-as-potential-correlates-of-internalized-mental-health-symptoms-among-canadian-adolescents
#13
Caroline Piccininni, Valerie Michaelson, Ian Janssen, William Pickett
Exposures to outdoor environments have great potential to be protective factors for the mental health of young people. In a national analysis of Canadian adolescents, we explored how such exposures, as well as self-perceptions of connectedness with nature, each related to the prevalence of recurrent psychosomatic symptoms. The data source for this cross-sectional study, consisting of a weighted sample of 29,784 students aged 11-15 years from 377 schools, was the 2013/2014 cycle of the Health Behaviour in School-aged Children (HBSC) study...
April 18, 2018: Preventive Medicine
https://www.readbyqxmd.com/read/29679558/self-restrained-regulation-of-stem-cell-niche-activity-by-niche-components-in-the-drosophila-testis
#14
Ran Xu, Jing Li, Hang Zhao, Ruiyan Kong, Min Wei, Lin Shi, Guang Bai, Zhouhua Li
Most, if not all, stem cells reside in a defined microenvironment, called the niche. Short-ranged niche signal must be tightly controlled to be active only inside the niche to maintain the proper balance of stem cell self-renewal verse differentiation. However, how niche components restrict localized niche signal activation remains largely unknown. Here, we find that Thickveins (Tkv, a type I receptor of the Dpp signaling pathway) in cyst stem cells (CySCs) of the testis niche prevents Dpp signaling activation outside of the niche...
April 18, 2018: Developmental Biology
https://www.readbyqxmd.com/read/29679485/identification-and-structure-elucidation-of-the-proresolving-mediators-provides-novel-leads-for-resolution-pharmacology
#15
REVIEW
Jesmond Dalli, Charles N Serhan
Inflammatory diseases are a major socioeconomic burden, with the incidence of such conditions on the rise, especially in western societies. For decades, the primary treatment paradigm for many of these conditions was to develop drugs that inhibit or antagonize the production and biological actions of molecules that were thought to be the culprits in propagating disease, these include cytokines and eicosanoids. This approach is effective in controlling disease propagation; however, long-term exposure to these anti-inflammatories is also associated with many side effects, some of which severe, including immune-suppression...
April 21, 2018: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29679445/development-of-coumarin-and-benzofuran-conjugated-hybrids-as-the-versatile-multi-targeted-compounds-for-the-treatment-of-alzheimer-s-disease
#16
Asha Hiremathad, Karam Chand, Rangappa S Keri
Alzheimer's disease (AD), the most common cause of dementia, is a neurodegenerative disorder characterized by progressive deterioration of memory and cognition. The evidenced multi-factorial nature of AD has been considered the main reason for the absence of cure so far. Therefore, the development of novel hybrids to treat the disease is very much essential. Focusing on this, a novel series of coumarin-benzofuran conjugated hybrids have been designed and screened as anti-Alzheimer's disease agents. The strategy is to obtain an effective mimetic of donepezil, which is acetylcholnesterase inhibitor...
April 20, 2018: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/29679419/sexual-orientation-differences-in-alcohol-use-trajectories-and-disorders-in-emerging-adulthood-results-from-a-longitudinal-cohort-study-in-the-united-states
#17
Robert W S Coulter, Hee-Jin Jun, Jerel P Calzo, Nhan L Truong, Christina Mair, Nina Markovic, Brittany M Charlton, Anthony J Silvestre, Ron Stall, Heather L Corliss
AIMS: We estimated sexual-orientation differences in alcohol use trajectories during emerging adulthood, and tested whether alcohol use trajectories mediated sexual-orientation differences in alcohol use disorders (AUDs). DESIGN: Longitudinal self-reported survey data from the Growing Up Today Study. SETTING: USA. PARTICIPANTS: 12,493 participants aged 18-25 during the 2003, 2005, 2007, or 2010 surveys. MEASUREMENTS: Stratified by gender, longitudinal latent class analyses estimated alcohol use trajectories (using past-year frequency, quantity, and binge drinking from 2003-2010)...
April 21, 2018: Addiction
https://www.readbyqxmd.com/read/29679412/influence-of-the-medication-environment-on-the-unsafe-medication-behavior-of-nurses-a-path-analysis
#18
Xi Yu, Ce Li, Xueqin Gao, Furong Liu, Ping Lin
AIMS AND OBJECTIVES: To explore the relationship between the medication environment and the unsafe medication behavior of nurses and to analyze its influence path. BACKGROUND: Unsafe medication behavior is the direct cause of medication error. The organizational environment is the foundation of and plays a guiding role in work behavior. Whether the medication environment correlates with the unsafe medication behavior of nurses remains unclear. DESIGN: This study used a correlative design with self-administered questionnaires, and the SHEL model, an acronym of its elements of software, hardware, environment, and liveware, was used as the framework for the medication environment...
April 20, 2018: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/29679410/associations-of-ultra-processed-food-and-drink-products-with-asthma-and-wheezing-among-brazilian-adolescents
#19
B Melo, L Rezende, P Machado, N Gouveia, R Levy
BACKGROUND: Although both consumption of ultra-processed products and asthma are common during adolescence, the epidemiological evidence in regarding their association is unclear. We investigated the associations of ultra-processed products consumption with asthma and wheezing in a representative sample of Brazilian adolescents. METHODS: We used data from a representative sample of 109,104 Brazilian adolescents enrolled in the National Survey of School Health, 2012...
April 21, 2018: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/29679402/person-centred-leadership-a-relational-approach-to-leadership-derived-through-action-research
#20
Shaun Cardiff, Brendan McCormack, Tanya McCance
AIMS & OBJECTIVES: How does person-centred leadership manifest in clinical nursing. BACKGROUND: Person-centred practice fosters healthful relationships and is gaining increasing attention in nursing and healthcare, but nothing is known about the influence of a person-centred approach to leadership practice. Most leadership models used in nursing were originally developed outside of nursing. DESIGN: A three year participatory action research study where participant leaders planned, researched and learned from their practice development...
April 21, 2018: Journal of Clinical Nursing
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