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https://www.readbyqxmd.com/read/29909595/disability-experiences-and-perspectives-regarding-reproductive-decisions-parenting-and-the-utility-of-genetic-services-a-qualitative-study
#1
C Roadhouse, C Shuman, K Anstey, K Sappleton, D Chitayat, E Ignagni
Genetic counselors adopt seemingly contradictory roles: advocating for individuals with genetic conditions while offering prenatal diagnosis and the option of selective termination to prevent the birth of a child with a disability. This duality contributes to the tension between the disability and clinical genetics communities. Varying opinions exist amongst the disability community: some value genetic services while others are opposed. However, there is limited research exploring the opinions of individuals with a disability regarding issues related to reproduction and genetic services in the context of personal experience...
June 16, 2018: Journal of Genetic Counseling
https://www.readbyqxmd.com/read/29909594/the-influence-of-adolescence-on-parents-perspectives-of-testing-and-discussing-inherited-cancer-predisposition
#2
Corinna L Schultz, Melissa A Alderfer, Robert B Lindell, Zachary McClain, Kristin Zelley, Kim E Nichols, Carol A Ford
Li-Fraumeni syndrome (LFS) is a highly penetrant cancer predisposition syndrome that may present with a first cancer before or during adolescence/young adulthood. Families offered LFS genetic testing for their children can inform our understanding of how the unique developmental context of adolescence influences parental perspectives about genetic testing and discussions of cancer risk. In this study, semi-structured interviews were conducted with 46 parents of children at risk for LFS to capture those perspectives...
June 16, 2018: Journal of Genetic Counseling
https://www.readbyqxmd.com/read/29909591/update-on-the-use-of-c1-esterase-inhibitor-replacement-therapy-in-the-acute-and-prophylactic-treatment-of-hereditary-angioedema
#3
REVIEW
H Henry Li, Marc Riedl, Jay Kashkin
In the vast majority of patients with hereditary angioedema (HAE), angioedema attacks are due to the quantitative or functional deficiency of C1-esterase inhibitor (C1-INH), which leads to increased vascular permeability and unregulated release of bradykinin. Exogenous administration of C1-INH is a rational way to restore the concentration and functional activity of this protein, regulate the release of bradykinin, and attenuate or prevent subcutaneous and submucosal edema associated with HAE. Recent international guidelines for the management of HAE include C1-INH as an option for acute treatment of HAE...
June 16, 2018: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/29909590/do-cta-measurements-of-annular-diameter-perimeter-and-area-result-in-different-tavi-prosthesis-sizes
#4
Barbora Horehledova, Casper Mihl, Babs M F Hendriks, Nienke G Eijsvoogel, Jindrich Vainer, Leo F Veenstra, Joachim E Wildberger, Marco Das
Incorrect prosthesis size has direct impact on patient outcome after transcatheter aortic valve implantation (TAVI) procedure. Currently, annular diameter, area or perimeter may be used for prosthesis size selection. The aim was to evaluate whether the use different annular dimensions would result in the selection of different prosthesis sizes, when assessed in the same TAVI-candidate during the same phase of a cardiac cycle. Fifty consecutive TAVI-candidates underwent retrospectively ECG-gated computed tomography angiography (CTA)...
June 16, 2018: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/29909589/-it-was-not-my-aim-to-sleep-there-the-impact-of-timing-and-location-of-sex-on-adherence-to-coitally-dependent-hiv-pre-exposure-prophylaxis
#5
Fiona Scorgie, Jonathan Stadler, Deborah Baron, Susan Ju, Tshepiso Ikaneng, Zonke Mabude, Sylvia Makgopa, Matshidiso A Malefo, Kgahlisho N Manenzhe, Thulani Mazibuko, Hilda Ntjana, Busi Nkala, Thesla Palanee-Phillips, Glenda Gray, Helen Rees, Sinead Delany-Moretlwe
The FACTS 001 trial found that vaginal pre- and post-coital application of 1% tenofovir gel did not prevent HIV-1 infection amongst young South African women. The trial included a multi-faceted approach to adherence support and collected objective and self-reported adherence measures. Using qualitative data collected from a random sub-set of FACTS 001 participants (135 in-depth interviews at product discontinuation and 13 focus group discussions at dissemination of trial results), we explore the importance of 'place' and 'timing' in shaping acts of sexual intimacy and product adherence...
June 16, 2018: AIDS and Behavior
https://www.readbyqxmd.com/read/29909567/paravertebral-blocks-reduce-the-risk-of-postoperative-urinary-retention-in-inguinal-hernia-repair
#6
E Bojaxhi, J Lee, S Bowers, R D Frank, S H Pak, A Rosales, S Padron, R A Greengrass
PURPOSE: Inguinal hernia repair and general anesthesia (GA) are known risk factors for urinary retention. Paravertebral blocks (PVBs) have been utilized to facilitate enhanced recovery after surgery. We evaluate the benefit of incorporating PVBs into our anesthetic technique in a large cohort of ambulatory patients undergoing inguinal hernia repair. METHODS: Records of 619 adults scheduled for ambulatory inguinal hernia repair between 2010 and 2015 were reviewed and categorized based on anesthetic and surgical approach [GA and open (GAO), GA and laparoscopic (GAL), PVB and open (PVBO), and GA/PVB and open (GA/PVBO)]...
June 16, 2018: Hernia: the Journal of Hernias and Abdominal Wall Surgery
https://www.readbyqxmd.com/read/29909544/weight-management-weight-perceptions-and-health-compromising-behaviours-among-adolescent-girls-in-the-compass-study
#7
Amanda Raffoul, Scott T Leatherdale, Sharon I Kirkpatrick
Evidence suggests associations between weight management intentions, weight perceptions, and health-compromising behaviours among adolescent girls. Drawing on cross-sectional data for 21,456 girls, we employed multinomial logistic regression to examine whether smoking, binge drinking, and breakfast-skipping were associated with weight management intentions and weight perceptions. According to self-reported heights and weights, 61.4% of girls were in the healthy weight category. However, most reported trying to manage their weight, with 58% trying to lose, 4...
June 16, 2018: Journal of Primary Prevention
https://www.readbyqxmd.com/read/29909522/why-don-t-segregated-roma-do-more-for-their-health-an-explanatory-framework-from-an-ethnographic-study-in-slovakia
#8
Andrej Belak, Andrea Madarasova Geckova, Jitse P van Dijk, Sijmen A Reijneveld
OBJECTIVES: The health status of segregated Roma is poor. To understand why segregated Roma engage in health-endangering practices, we explored their nonadherence to clinical and public health recommendations. METHODS: We examined one segregated Roma settlement of 260 inhabitants in Slovakia. To obtain qualitative data on local-level mechanisms supporting Roma nonadherence, we combined ethnography and systematic interviewing over 10 years. We then performed a qualitative content analysis based on sociological and public health theories...
June 16, 2018: International Journal of Public Health
https://www.readbyqxmd.com/read/29909518/the-african-indigenous-lens-of-understanding-spirituality-reflection-on-key-emerging-concepts-from-a-reviewed-literature
#9
Chioma Ohajunwa, Gubela Mji
In this paper, we will present a reflection on reviewed literature on African indigenous understanding of spirituality, highlighting the influence of this concept on notions of the self, motivation and well-being. The indigenous understanding of spirituality is central to the understanding of the self as distinct, but positioned within the relational-collective self. This African indigenous perception of the self is grounded within the autonomous experience of the tenets of spirituality, which is explored in this paper through the lens of self-determination theory...
June 16, 2018: Journal of Religion and Health
https://www.readbyqxmd.com/read/29909483/understanding-patient-reported-outcome-measures-in-huntington-disease-at-what-point-is-cognitive-impairment-related-to-poor-measurement-reliability
#10
N E Carlozzi, S Schilling, A L Kratz, J S Paulsen, S Frank, J C Stout
PURPOSE: Symptom progression in Huntington disease (HD) is associated with cognitive decline which may interfere with the self-report of symptoms. Unfortunately, data to support or refute the psychometric reliability of patient-reported outcomes (PROs) as HD progresses are limited. This is problematic given that PROs are increasingly recognized as important measures of efficacy for new treatments. METHODS: We examined PRO data from the HDQLIFE Measurement System (Speech Difficulties; Swallowing Difficulties; Chorea) in 509 individuals with premanifest, early-stage, or late-stage HD...
June 16, 2018: Quality of Life Research
https://www.readbyqxmd.com/read/29909480/attitudes-towards-seeking-psychological-help-an-integrative-model-based-on-contact-essentialist-beliefs-about-mental-illness-and-stigma
#11
Alexandra Hantzi, Fotios Anagnostopoulos, Eva Alexiou
Based on intergroup contact theory, a proposed comprehensive model of attitudes towards seeking professional psychological help was tested, including both potential barriers to mental health help-seeking (i.e., public stigma and self-stigma of seeking help, prejudicial and essentialist beliefs about mental illness, intergroup anxiety) and potential facilitators (i.e., direct and extended contact with persons with mental illness). Relevant measures were completed by 119 community-dwelling participants. Path analysis showed that direct (but not extended) contact with mental illness, by reducing intergroup anxiety, led to less negative beliefs about mental illness and weaker essentialist beliefs about mental illness (the latter being directly and positively associated with negative beliefs about mental illness)...
June 16, 2018: Journal of Clinical Psychology in Medical Settings
https://www.readbyqxmd.com/read/29909476/the-use-of-ehealth-to-promote-physical-activity-in-cancer-survivors-a-systematic-review
#12
Ciarán Haberlin, Tom O'Dwyer, David Mockler, Jonathan Moran, Dearbhaile M O'Donnell, Julie Broderick
PURPOSE: Achieving adequate levels of physical activity (PA) and avoiding sedentary behaviour are particularly important in cancer survivors. eHealth, which includes, but is not limited to, the delivery of health information through Internet and mobile technologies, is an emerging concept in healthcare which may present opportunities to improve PA in cancer survivors. The aim of this systematic review was to explore the effects of eHealth in the promotion of PA among cancer survivors...
June 16, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29909456/construction-of-a-thermoresponsive-magnetic-porous-polymer-membrane-enzyme-reactor-for-glutaminase-kinetics-study
#13
Liping Zhao, Juan Qiao, Meyong Hee Moon, Li Qi
Fabrication of polymer membranes with nanopores and a confinement effect toward enzyme immobilization has been an enabling endeavor. In the work reported here, an enzyme reactor based on a thermoresponsive magnetic porous block copolymer membrane was designed and constructed. Reversible addition-fragmentation chain transfer polymerization was used to synthesize the block copolymer, poly(maleic anhydride-styrene-N-isopropylacrylamide), with poly(N-isopropylacrylamide) as the thermoresponsive moiety. The self-assembly property of the block copolymer was used for preparation of magnetic porous thin film matrices with iron oxide nanoparticles...
June 16, 2018: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29909427/contrast-sensitivity-and-motion-discrimination-in-cannabis-users
#14
Elena Mikulskaya, Frances Heritage Martin
RATIONALE: Cannabis use impairs visual attention; however, it is unclear whether cannabis use also impairs low level visual processing or whether low level visual deficits can be related to lower dopaminergic functioning found in cannabis users. OBJECTIVES: To investigate whether spatiotemporal contrast sensitivity and motion discrimination under normal and low luminance conditions differ in cannabis users and non-users. METHODS: Control (n = 20) and cannabis (n = 21) participants completed a visual acuity test, a saliva test and self-report measures...
June 16, 2018: Psychopharmacology
https://www.readbyqxmd.com/read/29909425/binge-like-acquisition-of-%C3%AE-pyrrolidinopentiophenone-%C3%AE-pvp-self-administration-in-female-rats
#15
Mehrak Javadi-Paydar, Eric L Harvey, Yanabel Grant, Sophia A Vandewater, Kevin M Creehan, Jacques D Nguyen, Tobin J Dickerson, Michael A Taffe
RATIONALE: The synthetic cathinone α-pyrrolidinopentiophenone (α-PVP) has been associated with bizarre public behavior in users. Association of such behavior with extended binges of drug use motivates additional investigation, particularly since a prior study found that half of male rats experience a binge of exceptionally high intake, followed by sustained lower levels of self-administration during the acquisition of intravenous self-administration (IVSA) of a related drug, 3,4-methylenedioxypyrovalerone...
June 16, 2018: Psychopharmacology
https://www.readbyqxmd.com/read/29909373/what-insights-do-patients-and-caregivers-have-on-acute-kidney-injury-and-posthospitalisation-care-a-single-centre-qualitative-study-from-toronto-canada
#16
Samuel A Silver, Marianne Saragosa, Neill K Adhikari, Chaim M Bell, Ziv Harel, Andrea Harvey, Abhijat Kitchlu, Javier A Neyra, Ron Wald, Lianne Jeffs
OBJECTIVES: Hospitalisation with acute kidney injury (AKI) is associated with short-term and long-term adverse events, but patient and caregiver experiences with AKI are not well described. We sought to better understand patient and caregiver perspectives after a hospitalisation with AKI to inform discharge strategies that may improve outcomes for this high-risk population. DESIGN: Qualitative study with semistructured interviews. SETTING: Tertiary care hospital in Toronto, Ontario, Canada...
June 15, 2018: BMJ Open
https://www.readbyqxmd.com/read/29909349/who-is-prone-to-wander-and-when-examining-an-integrative-effect-of-working-memory-capacity-and-mindfulness-trait-on-mind-wandering-under-different-task-loads
#17
Yu-Jeng Ju, Yunn-Wen Lien
We proposed an integration hypothesis of mind wandering in which the tendency of mind wandering is only related to working memory capacity (WMC) when a self-regulation process is required (i.e., under a high task load); however, this tendency is related to mindfulness regardless of task load. A within-group experiment with 160 participants was conducted. Task load was manipulated as high or low using modified 0-back and 2-back tasks, during which participants' self-caught mind wanderings and the types of mind wandering (aware vs...
June 13, 2018: Consciousness and Cognition
https://www.readbyqxmd.com/read/29909302/affective-styles-in-mood-and-anxiety-disorders-clinical-validation-of-the-affective-style-questionnaire-asq
#18
Christina Totzeck, Tobias Teismann, Stefan G Hofmann, Ruth von Brachel, Xiao Chi Zhang, Verena Pflug, Jürgen Margraf
BACKGROUND: Emotion regulation plays a critical role in the development and maintenance of psychological disorders. Less is known about the association of affective styles and psychopathology. The 20-item "Affective Style Questionnaire" (ASQ) has been validated in nonclinical samples. The American and German validation studies resulted in a three-factor structure (concealing, adjusting, and tolerating). The present study aimed to investigate three aspects: (1) the validation of the ASQ within a clinical sample, (2) the examination of possible differences in affective styles between patients suffering from affective versus anxiety disorders, and (3) the association of affective styles and anxiety, depression, and stress symptoms...
June 2, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29909257/practice-and-effectiveness-of-web-based-problem-based-learning-approach-in-a-large-class-size-system-a-comparative-study
#19
Yongxia Ding, Peili Zhang
Problem-based learning (PBL) is an effective and highly efficient teaching approach that is extensively applied in education systems across a variety of countries. This study aimed to investigate the effectiveness of web-based PBL teaching pedagogies in large classes. The cluster sampling method was used to separate two college-level nursing student classes (graduating class of 2013) into two groups. The experimental group (n = 162) was taught using a web-based PBL teaching approach, while the control group (n = 166) was taught using conventional teaching methods...
June 12, 2018: Nurse Education in Practice
https://www.readbyqxmd.com/read/29909241/bone-breaking-infections-a-focus-on-bacterial-and-mosquito-borne-viral-infections
#20
REVIEW
Yan Chao Cui, Qiong Wu, Seoh Wei Teh, Amira Peli, Gang Bu, Yu Sheng Qiu, Giovanni Benelli, S Suresh Kumar
The recent global resurgence of arthritogenic alphaviruses, including Ross River, chikungunya, and dengue, highlights an urgency for the development of therapeutic strategies. Currently, dengue represents the most rapidly transmitting mosquito-borne viral disease worldwide. By contracting bone breaking diseases, patients experience devastating clinical manifestations involving muscle pain and bone loss. The bone self-repair and regeneration mechanisms can be damaged by the presence of viruses and bacteria. The rapid establishment of dengue epidemic and the severity of bacterial and viral infections affecting the bone stress the urgent need of developing effective interventions...
June 14, 2018: Microbial Pathogenesis
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