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https://www.readbyqxmd.com/read/28449284/pediatric-melanoma
#1
REVIEW
Christina Stefanaki, Leonidas Chardalias, Efthymia Soura, Alexandra Katsarou, Alexander Stratigos
Pediatric melanoma, although rare, is the most common skin cancer in children. Our current knowledge on pediatric melanoma incidence trends is expanding, as several studies have addressed this issue with conflicting results. Known risk factors for pediatric melanoma include family history of melanoma, a previous history of malignancy, large congenital nevi, numerous melanocytic nevi, sunburns, increased UV exposure and a sun-sensitive phenotype. In younger children melanoma more often presents with atypical features, such as a changing, amelanotic or uniformly colored, often bleeding lesion, not fulfilling in most cases the conventional ABCDE criteria...
April 27, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28447351/estimating-melanin-location-in-the-pigmented-skin-lesions-by-hue-saturation-lightness-color-space-values-of-dermoscopic-images
#2
REVIEW
Hiroshi Sakai, Yoshimi Ando, Kuniko Ikinaga, Masaru Tanaka
The depth of melanin in the skin can be estimated roughly by observation of the color exhibited on dermoscopy. Currently, there are no objective methods to estimate it. The aim of the present study was to clarify the relationship between the depth of melanin in the skin and the color variation exhibited, and to objectively estimate the 3-D location of melanin in the pigmented skin lesions from dermoscopic images. Representative colors in dermoscopic images of acral compound nevus, Spitz nevus and blue nevus were evaluated by the subjectively perceived color on dermoscopy and objective values in hue-saturation-lightness color space values...
May 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/28445445/cardioprotective-effects-of-malvidin-against-isoproterenol-induced-myocardial-infarction-in-rats-a-mechanistic-study
#3
Hui Wei, Hui Li, Shu-Ping Wan, Qiu-Tang Zeng, Long-Xian Cheng, Li-Li Jiang, Yu-Dong Peng
BACKGROUND Malvidin (alvidin-3-glucoside) is a polyphenol that belongs to the class of natural anthocyanin, which is abundantly found in red wines, colored fruits, and the skin of red grapes. Therefore, the current investigation was intended to evaluate the effect of malvidin against myocardial infarction induced by isoproterenol in the rats. MATERIAL AND METHODS The cardioprotective effects was assessed by determining the effect of malvidin on the activities of endogenous antioxidants - catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GSH) - and on the levels of lipid peroxidation and serum marker enzymes...
April 26, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28443103/genotyping-by-sequencing-for-snp-based-linkage-analysis-and-identification-of-qtls-linked-to-fruit-quality-traits-in-japanese-plum-prunus-salicina-lindl
#4
Juan A Salazar, Igor Pacheco, Paulina Shinya, Patricio Zapata, Claudia Silva, Mallikarjuna Aradhya, Dianne Velasco, David Ruiz, Pedro Martínez-Gómez, Rodrigo Infante
Marker-assisted selection (MAS) in stone fruit (Prunus species) breeding is currently difficult to achieve due to the polygenic nature of the most relevant agronomic traits linked to fruit quality. Genotyping by sequencing (GBS), however, provides a large quantity of useful data suitable for fine mapping using Single Nucleotide Polymorphisms (SNPs) from a reference genome. In this study, GBS was used to genotype 272 seedlings of three F1 Japanese plum (Prunus salicina Lindl) progenies derived from crossing "98-99" (as a common female parent) with "Angeleno," "September King," and "September Queen" as male parents...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28442871/epithelioma-adenoides-cysticum-a-report-of-two-cases-in-a-family
#5
Najeeba Riyaz, Bindurani Sudhamani, Arakkal Riyaz
Epithelioma adenoides cysticum or multiple trichoepitheliomas are rare benign hamartomas arising from the hair germ. A 35-year-old female presented with multiple skin-colored firm papules and nodules mainly affecting the central face, scalp, and external ear canal since the age of 9 years. The lesions gradually increased with age. Her 13-year-old son also had similar but smaller lesions on the central face. Histopathology was consistent with trichoepithelioma.
October 2016: International Journal of Trichology
https://www.readbyqxmd.com/read/28440563/the-sumo-e3-ligase-mdsiz1-promotes-anthocyanin-accumulation-by-sumoylating-mdmyb1-under-low-temperature-conditions-in-apple
#6
Li-Jie Zhou, Yuan-Yuan Li, Rui-Fen Zhang, Chun-Ling Zhang, Xing-Bin Xie, Cheng Zhao, Yu-Jin Hao
MdMYB1 acts as a crucial component of the MYB-bHLH-WD40 (MBW) complex to regulate anthocyanin biosynthesis in red-skinned apples (Malus domestica), but little is known about its posttranslational regulation. Here, a SUMO E3 ligase MdSIZ1 was screened out as an MdMYB1-interacting protein with a yeast two-hybridization approach. The interaction between MdSIZ1 and MdMYB1 was further verified with pull-down and CoIP assays. Furthermore, it was found that MdSIZ1 directly sumoylated MdMYB1 proteins in vivo and in vitro, especially under moderately low temperature (17 °C) conditions, and that this sumoylation was required for MdMYB1 protein stability...
April 25, 2017: Plant, Cell & Environment
https://www.readbyqxmd.com/read/28439965/identifying-signatures-of-positive-selection-in-pigmentation-genes-in-two-south-asian-populations
#7
Manjari Jonnalagadda, Neeraj Bharti, Yatish Patil, Shantanu Ozarkar, Sunitha Manjari K, Rajendra Joshi, Heather Norton
OBJECTIVES: Skin pigmentation is a polygenic trait showing wide phenotypic variations among global populations. While numerous pigmentation genes have been identified to be under positive selection among European and East populations, genes contributing to phenotypic variation in skin pigmentation within and among South Asian populations are still poorly understood. The present study uses data from the Phase 3 of the 1000 genomes project focusing on two South Asian populations-GIH (Gujarati Indian from Houston, Texas) and ITU (Indian Telugu from UK), so as to decode the genetic architecture involved in adaptation to ultraviolet radiation in South Asian populations...
April 24, 2017: American Journal of Human Biology: the Official Journal of the Human Biology Council
https://www.readbyqxmd.com/read/28437469/virtual-race-transformation-reverses-racial-in-group-bias
#8
Béatrice S Hasler, Bernhard Spanlang, Mel Slater
People generally show greater preference for members of their own racial group compared to racial out-group members. This type of 'in-group bias' is evident in mimicry behaviors. We tend to automatically mimic the behaviors of in-group members, and this behavior is associated with interpersonal sensitivity and empathy. However, mimicry is reduced when interacting with out-group members. Although race is considered an unchangeable trait, it is possible using embodiment in immersive virtual reality to engender the illusion in people of having a body of a different race...
2017: PloS One
https://www.readbyqxmd.com/read/28431132/revealing-the-biochemical-and-genetic-basis-of-colour-variation-in-a-polymorphic-lizard
#9
Claire A McLean, Adrian Lutz, Katrina J Rankin, Devi Stuart-Fox, Adnan Moussalli
Determining the mechanistic and genetic basis of animal coloration is essential to understand the costs and constraints on colour production, and the evolution and maintenance of phenotypic variation. However, genes underlying structural colour and widespread pigment classes apart from melanin remain largely uncharacterised, in part due to restricted taxonomic focus. We combined liquid chromatography-mass spectrometry and RNA-seq gene expression analyses to characterise the pigments and genes associated with skin colour in the polymorphic lizard, Ctenophorus decresii...
April 18, 2017: Molecular Biology and Evolution
https://www.readbyqxmd.com/read/28431039/genomic-data-for-78-chickens-from-14-populations
#10
Diyan Li, Tiandong Che, Binlong Chen, Shilin Tian, Xuming Zhou, Guolong Zhang, Miao Li, Uma Gaur, Yan Li, Majing Luo, Long Zhang, Zhongxian Xu, Xiaoling Zhao, Huadong Yin, Yan Wang, Long Jin, Qianzi Tang, Huailiang Xu, Mingyao Yang, Rongjia Zhou, Ruiqiang Li, Qing Zhu, Mingzhou Li
Background: Since the domestication of the red jungle fowls ( Gallus gallus ) (dating back to ∼10,000 B.P.) in Asia, domestic chickens ( Gallus gallus domesticus ) have been subjected to the combined effects of natural selection and human-driven artificial selection; this has resulted in marked phenotypic diversity in a number of traits, including behavior, body composition, egg production and skin color. Population genomic variations through diversifying selection have not been fully investigated...
April 18, 2017: GigaScience
https://www.readbyqxmd.com/read/28427800/the-effect-of-optune%C3%A2-tumor-treating-fields-transducer-arrays-on-skin-radiation-dose-during-radiotherapy
#11
Edward Bender, Kevin Kozak, Steven Howard, Lori Hayes, John Bayouth, H Ian Robins
A Phase 3 clinical study demonstrated that the addition of 200kHz Tumor Treating Fields (TTF) to temozolomide in the post-radiation (RT) phase of therapy in newly diagnosed glioblastoma increases progression free and overall survival (resulting in FDA and European Union approval). Preclinical studies have demonstrated the ability of TTF to act as a radiosensitizer, suggesting concurrent TTF and RT may have clinical utility. The removal and replacement of TTF transducer arrays from the scalps of patients on a daily basis, i...
April 17, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28423134/infant-mortality-by-color-or-race-from-rond%C3%A3-nia-brazilian-amazon
#12
Caroline Gava, Andrey Moreira Cardoso, Paulo Cesar Basta
OBJECTIVE: To analyze the quality of records for live births and infant deaths and to estimate the infant mortality rate for skin color or race, in order to explore possible racial inequalities in health. METHODS: Descriptive study that analyzed the quality of records of the Live Births Information System and Mortality Information System in Rondônia, Brazilian Amazonian, between 2006-2009. The infant mortality rates were estimated for skin color or race with the direct method and corrected by: (1) proportional distribution of deaths with missing data related to skin color or race; and (2) application of correction factors...
April 10, 2017: Revista de Saúde Pública
https://www.readbyqxmd.com/read/28412949/skin-whitening-among-cameroonian-female-university-students-knowledge-attitudes-practices-and-motivations
#13
Emmanuel Armand Kouotou, Jobert Richie N Nansseu, Hugues Adegbidi, Theophane Christel Joel Zoa Mebara, Elie Claude Ndjitoyap Ndam
BACKGROUND: Lack of data on skin whitening (SW) among Cameroonian female university students prompted us to undertake the present study which aimed at assessing the knowledge, attitudes, practices and motivations of female university students vis-a-vis SW. METHODS: This was a cross-sectional study conducted from January to April 2013 in 4 university campuses of Yaoundé, Cameroon. Any female student regularly registered in one of the study sites, who was present at the campus when the investigator visited and volunteered to participate in the study was enrolled...
April 17, 2017: BMC Women's Health
https://www.readbyqxmd.com/read/28412633/relationship-among-color-development-anthocyanin-and-pigment-related-gene-expression-in-crimson-seedless-grapes-treated-with-abscisic-acid-and-sucrose
#14
Daniela Olivares, Carolina Contreras, Victoria Muñoz, Sebastián Rivera, Mauricio González-Agüero, Julio Retamales, Bruno G Defilippi
'Crimson Seedless' is one of the most important table grape varieties in Chile, but under certain environmental conditions, the fruit exhibits inadequate red color development, causing economic losses due to lower product quality. The use of plant growth regulators, such as abscisic acid (ABA) and ethylene, during development increases the anthocyanin content of the skin, improving the color of the berry. Recently, sucrose has been identified as a signaling molecule capable of regulating the expression of genes of the anthocyanin biosynthesis pathway...
April 6, 2017: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/28411841/the-molecular-revolution-in-cutaneous-biology-the-era-of-genome-wide-association-studies-and-statistical-big%C3%A2-data-and-computational-topics
#15
REVIEW
Hima Anbunathan, Anne M Bowcock
The investigation of biological systems involving all organs of the body including the skin is in era of big data. This requires heavy-duty computational tools, and novel statistical methods. Microarrays have allowed the interrogation of thousands of common genetic markers in thousands of individuals from the same population (termed genome wide association studies or GWAS) to reveal common variation associated with disease or phenotype. These markers are usually single nucleotide polymorphisms (SNPs) that are relatively common in the population...
May 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28408914/transcriptome-analysis-reveals-candidate-genes-related-to-color-fading-of-red-bartlett-pyrus-communis-l
#16
Zhigang Wang, Hong Du, Rui Zhai, Linyan Song, Fengwang Ma, Lingfei Xu
The red color of fruit is an attractive plant trait for consumers. Plants with color-faded fruit have a lower commercial value, such as 'Red Bartlett' pears (Pyrus communis L.) that have dark-red fruit in the early stages of fruit development that subsequently fade to red-green at maturity. To identify the reason for color fading, we first analyzed the anthocyanin content of peel from 'Red Bartlett,' which displays the color fading phenomenon, and 'Starkrimson,' which has no color fading. Results showed that the anthocyanin content of 'Red Bartlett' peel decreased significantly late in fruit development, while in 'Starkrimson' there was no significant decrease...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28407952/common-food-colorants-and-allergic-reactions-in-children-myth-or-reality
#17
REVIEW
Gavriela Feketea, Sophia Tsabouri
Various additives, including food colorants (FCs), are used in the food industry to make food appealing to consumers and to add variety. Despite the widespread usage of FCs, adverse reactions related to their consumption, including reactions triggered by immune (immediate and delayed-type hypersensitivity) and non-immune (intolerance) mechanisms, are considered rare. There is a discrepancy between the perception of patients and parents (7.4%) and the reported prevalence of adverse reactions to additives (0...
September 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28403271/clinical-assessment-of-immediate-and-long-term-effects-of-a-two-step-topical-hyaluronic-acid-lip-treatment
#18
Elizabeth T Makino, Priscilla Tan, Kun Qian, Michael Babcock, Rahul C Mehta
<p>Key features of lip aging include loss of volume, color, and definition as well as increases in lines/wrinkles and uneven skin texture. A single-center, open-label clinical study was conducted to assess the efficacy and tolerability of a novel, topical two-step lip treatment (HA5 LS) in female subjects presenting with mild to moderate lip dryness and mild to severe lip condition. Subjects were instructed to apply HA5 LS at least three times a day to ensure coverage 8 hours a day for four weeks. Clinical assessments for efficacy and tolerability were conducted at baseline, baseline post-application, week 2, and week 4...
April 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28403265/improvement-of-atrophic-acne-scars-in-skin-of-color-using-topical-synthetic-epidermal-growth-factor-egf-serum-a-pilot-study
#19
Marie Alexia Stoddard, Jennifer Herrmann, Lauren Moy, Ronald Moy
<p>BACKGROUND: Atrophic scarring in skin of color is a common, permanent, and distressing result of uncontrolled acne vulgaris. Ablative lasers and chemical peels are frequently used to improve the appearance of atrophic scars, primarily through the stimulation of collagen and elastin; however, these treatment modalities are associated with risks, such as dyspigmentation and hypertrophic scarring, especially in patients with darker skin.</p> <p>OBJECTIVE: We evaluated the efficacy of topically applied synthetic epidermal growth factor (EGF) serum in reducing the appearance of atrophic acne scars in skin of color...
April 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28403262/combination-of-in-office-chemical-peels-with-a-topical-comprehensive-pigmentation-control-product-in-skin-of-color-subjects-with-facial-hyperpigmentation
#20
Jeanine Downie, Katie Schneider, Lisa Goberdhan, Elizabeth T Makino, Rahul C Mehta
<p>Dyschromia is one of the primary complaints for patients with skin of color. Treatments need to achieve a balance between tolerability and efficacy to address existing hyperpigmentation without causing additional damage that could trigger post-inflammatory hyperpigmentation (PIH). An open-label, single-center study was conducted to assess the efficacy of a novel comprehensive pigmentation control serum (LYT2) combined with a series of three very superficial chemical peels (VP) in skin of color subjects...
April 1, 2017: Journal of Drugs in Dermatology: JDD
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