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https://www.readbyqxmd.com/read/28893407/risk-of-malignancy-with-systemic-psoriasis-treatment-in-the-psoriasis-longitudinal-assessment-registry
#1
David Fiorentino, Vincent Ho, Mark G Lebwohl, Luiz Leite, Lori Hopkins, Claudia Galindo, Kavitha Goyal, Wayne Langholff, Steven Fakharzadeh, Bhaskar Srivastava, Richard G Langley
BACKGROUND: The effect of systemic therapy on malignancy risk among patients with psoriasis is not fully understood. OBJECTIVE: Evaluate the impact of systemic treatment on malignancy risk among patients with psoriasis in the Psoriasis Longitudinal Assessment and Registry (PSOLAR). METHODS: Nested case-control analyses were performed among patients with no history of malignancy. Cases were defined as first malignancy (other than nonmelanoma skin cancer) in the Psoriasis Longitudinal Assessment and Registry, and controls were matched by age, sex, geographic region, and time on registry...
September 8, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28886803/optical-coherence-tomography-in-the-diagnosis-of-skin-cancer
#2
REVIEW
Amanda Levine, Katie Wang, Orit Markowitz
Optical coherence tomography (OCT) has emerged as a novel noninvasive imaging device that allows for the real-time, in vivo, cross-sectional imaging of skin morphology. OCT has increased imaging depth and field of view compared with reflectance confocal microscopy, at the cost of decreased cellular resolution. Frequency domain OCT, dynamic OCT (D-OCT), and high-definition OCT (HD-OCT) are useful in the diagnosis, treatment planning, and treatment monitoring of nonmelanoma skin cancers. Research is currently underway to assess the utilization of these devices in distinguishing between malignant and benign melanocytic lesions based on vascular patterns on D-OCT and cellular information on HD-OCT...
October 2017: Dermatologic Clinics
https://www.readbyqxmd.com/read/28886797/clinical-diagnosis-of-skin-cancer-enhancing-inspection-and-early-recognition
#3
REVIEW
Alex M Glazer, Darrell S Rigel, Richard R Winkelmann, Aaron S Farberg
The annual incidence rate for melanoma and nonmelanoma skin cancer continues to rise and morbidity and deaths from skin cancer are increasing. Despite advances in therapeutics, the factors that most impact prognosis remain early recognition and removal of neoplasms before deep invasion or metastatic disease can occur. There are numerous public health and screening initiatives that have been introduced to help recognize disease earlier and to increase patients' awareness of signs or changes of lesions that may represent skin cancers...
October 2017: Dermatologic Clinics
https://www.readbyqxmd.com/read/28885696/survivorship-care-planning-in-skin-cancer-an-unbiased-statistical-approach-to-identifying-patterns-of-care-plan-use
#4
Joseph L Benci, Andy J Minn, Carolyn C Vachani, Christina Bach, Karen Arnold-Korzeniowski, Margaret K Hampshire, James M Metz, Christine E Hill-Kayser
BACKGROUND: Nearly 1 in 5 Americans will develop skin cancer, and as a result, survivors of skin cancer compose one of the largest groups of cancer survivors. Survivorship care plans (SCPs) are an important tool for improving patient outcomes and provide critical information to both survivors and health care professionals. Recent efforts have been made to expand SCP utilization; however, which patients currently receive SCPs is poorly understood. METHODS: This study used 596 individuals with a diagnosis of melanoma (n = 391) or nonmelanoma skin cancer (n = 205) who had used an Internet-based SCP tool from May 2010 to December 2016 to model the patient and provider characteristics that determine SCP utilization...
September 8, 2017: Cancer
https://www.readbyqxmd.com/read/28873118/topical-timolol-may-improve-overall-scar-cosmesis-in-acute-surgical-wounds
#5
Ganary Dabiri, Jeffrey Tiger, Renato Goreshi, Allison Fischer, Satori Iwamoto
Acute wounds created by dermatologists following the removal of nonmelanoma skin cancers are closed either by primary or secondary intention, and the best cosmetic outcome is preferentially desired. One parameter that determines the overall cosmesis of the healed wound is its vascularity. Vascular tone results from a complex interplay of a variety of chemokines in the body and their interaction with receptors located on endothelial cell surfaces. In this study, our aim was to determine if topical timolol could improve the overall cosmesis of acute surgical wounds...
July 2017: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/28858932/utilization-of-topographical-mohs-micrographic-surgery-maps-for-rapid-review-of-clinicopathologic-characteristics-of-nonmelanoma-skin-cancers-of-the-ear
#6
Stanislav N Tolkachjov
BACKGROUND: Nonmelanoma skin cancers (NMSCs) of the ear are considered high risk. Precise location of tumor sites is important when identifying surgical treatment sites. OBJECTIVE: Review precise locations and histopathologic subtypes of auricular NMSC treated with Mohs micrographic surgery (MMS) using a standardized topographical numbering system for rapid data extraction. MATERIALS AND METHODS: Using a MMS topographical number system, the author performed a retrospective chart review of 649 consecutive patients treated with MMS at Mayo Clinic for primary cutaneous basal cell carcinomas (BCCs) or squamous cell carcinomas (SCCs) of the ear...
August 29, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28857942/correlation-between-original-biopsy-pathology-and-mohs-intraoperative-pathology
#7
Evan Stiegel, Charlene Lam, Michael Schowalter, Ally-Khan Somani, Jennifer Lucas, Christine Poblete-Lopez
BACKGROUND: The pathology observed on initial biopsy specimens for nonmelanoma skin cancer (NMSC), specifically the tumor subtype, weighs heavily into the selection of the treatment modality. Recognizing aggressive features on intraoperative Mohs micrographic surgery (MMS) frozen sections that were not indicated on initial biopsy reports is not uncommon. To date, there is limited data describing this discrepancy. OBJECTIVE: To investigate the frequency and nature of incongruity between the pathology seen in initial biopsies and intraoperative Mohs sections, providing information that will potentially impact skin cancer treatment and biopsy recommendations...
August 28, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28838412/intestinal-and-nonintestinal-cancer-risks-for-patients-with-crohn-s-disease
#8
REVIEW
Sushil K Garg, Fernando S Velayos, John B Kisiel
Crohn's disease (CD) is a chronic inflammatory disease that confers a higher risk of cancer than in the general population. New, large, population-based studies in the past decade show that patients with CD are at higher risk of colorectal, small bowel, melanoma, and cervical cancer. Patients who use thiopurines are at additional risk of development of lymphoma and nonmelanoma skin cancer. Preventive surveillance for cancers of the colorectum, skin, and uterine cervix is advised.
September 2017: Gastroenterology Clinics of North America
https://www.readbyqxmd.com/read/28832880/association-of-vitamin-d-receptor-polymorphisms-with-the-risk-of-nonmelanoma-skin-cancer-in-adults
#9
Erin M Burns, Purushotham Guroji, Israr Ahmad, Hana M Nasr, Yingxue Wang, Iman A Tamimi, Elijah Stiefel, Mohammad S Abdelgawwad, Abdullah Shaheen, Anum F Muzaffar, Lisa M Bush, Christina B Hurst, Russell L Griffin, Craig A Elmets, Nabiha Yusuf
Importance: Protective effects of UV-B radiation against nonmelanoma skin cancer (NMSC) are exerted via signaling mechanisms involving the vitamin D receptor (VDR). Recent studies have examined single-nucleotide polymorphisms (SNPs) in the VDR, resulting in contradictory findings as to whether these polymorphisms increase a person's risk for NMSC. Objective: To examine whether the polymorphisms in the VDR gene are associated with the development of NMSC and the demographic characteristics of the participants...
August 23, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28799948/anticancer-drugs-and-the-regulation-of-hedgehog-genes-gli1-and-ptch1-a-comparative-study-in-nonmelanoma-skin-cancer-cell-lines
#10
Uffe H Olesen, Sophie Bojesen, Julie Gehl, Merete Haedersdal
Nonmelanoma skin cancer is the most common cancer in humans, comprising mainly basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). BCC proliferation is highly dependent on the Hedgehog signaling pathway. We aimed to investigate a panel of anticancer drugs with known activity against skin cancer for their therapeutic potential in localized, enhanced topical treatment of SCC and BCC. Cytotoxicity profiles for vismodegib, 5-fluorouracil (5-FU), methotrexate (MTX), cisplatin, bleomycin, and vorinostat were established in terms of half maximal inhibitory concentration values in a panel of immortalized keratinocytes (HaCaT), BCC (UWBCC1 and BCC77015), and SCC (A431 and SCC25) cell lines...
August 9, 2017: Anti-cancer Drugs
https://www.readbyqxmd.com/read/28780365/risk-of-cutaneous-squamous-cell-carcinoma-after-treatment-of-basal-cell-carcinoma-with-vismodegib
#11
Tina Bhutani, Michael Abrouk, Camelia S Sima, Natalia Sadetsky, Jeannie Hou, Ivor Caro, Mary-Margaret Chren, Sarah T Arron
BACKGROUND: Vismodegib is a first-in-class agent targeting the hedgehog signaling pathway for treatment of patients with locally advanced basal cell carcinoma (BCC) and metastatic BCC. There have been concerns about the development of squamous cell carcinoma (SCC) in patients treated with this drug. OBJECTIVE: We sought to determine whether treatment with vismodegib is associated with an increase in the risk of cutaneous SCC. METHODS: In this retrospective cohort study, patients treated with vismodegib as part of phase I and II clinical studies were compared with participants from the University of California, San Francisco, Nonmelanoma Skin Cancer Cohort who received standard therapy for primary BCC...
October 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28780363/effect-of-voriconazole-on-risk-of-nonmelanoma-skin-cancer-after-hematopoietic-cell-transplantation
#12
Lawrence F Kuklinski, Shufeng Li, Margaret R Karagas, Wen-Kai Weng, Bernice Y Kwong
BACKGROUND: Voriconazole has previously been associated with increased risk for cutaneous squamous cell carcinoma (SCC) in solid organ transplant recipients. Less is known about the risk in patients after hematopoietic cell transplantation (HCT). OBJECTIVE: We evaluated the effect of voriconazole on the risk for nonmelanoma skin cancer (NMSC), including SCC and basal cell carcionoma, among those who have undergone allogeneic and autologous HCT. METHODS: In all, 1220 individuals who had undergone allogeneic HCT and 1418 who had undergone autologous HCT were included in a retrospective cohort study...
October 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28748684/prognostic-factors-in-head-and-neck-melanoma-according-to-facial-aesthetic-units
#13
Giovanni Paolino, Michele Cardone, Dario Didona, Elisa Moliterni, Luigi Losco, Paola Corsetti, Giusy Schipani, Teresa Lopez, Stefano Calvieri, Ugo Bottoni
BACKGROUND: Head and neck melanoma is a clinical challenge. Indeed, cutaneous head and neck melanoma shows a worse prognosis in comparison to melanomas of other body sites. Although the emphasis on facial cosmetic preservation plays a pivotal role in comparison to other body areas, specific facial aesthetic units could also play a key role in the prognostic evaluation of the malignancy. METHODS: The aim of the current study was to evaluate the general outcome and clinicopathological features of head and neck melanoma and to detect prognostic differences according to each facial aesthetic unit...
July 26, 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/28745396/alcohol-intake-and-risk-of-nonmelanoma-skin-cancer-a-systematic-review-and-dose-response-meta-analysis
#14
REVIEW
H Yen, A Dhana, J-P Okhovat, A Qureshi, N Keum, E Cho
Nonmelanoma skin cancer (NMSC) comprises mainly basal cell carcinoma (BCC) and cutaneous squamous cell carcinoma (cSCC). The association between alcohol intake and NMSC has been inconclusive; therefore the objective of this study is to quantify the relationship between alcohol intake and NMSC using meta-analyses. A systematic literature search of PubMed and Embase was performed on 30 October 2016. Eligible articles were case-control or cohort studies that examined alcohol intake and risk of BCC or cSCC and reported relative risks (RRs) with 95% confidence intervals (CIs)...
July 26, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28719713/lymph-node-positive-cutaneous-nonmelanoma-skin-cancer-a-poor-prognosis-disease-in-need-of-treatment-intensification
#15
Lora S Wang, Elizabeth A Handorf, John A Ridge, Barbara A Burtness, Miriam N Lango, Ranee Mehra, Jeffrey C Liu, Thomas J Galloway
Locoregionally advanced nonmelanoma skin cancer (NMSC) has an aggressive clinical course characterized by high rates of treatment failure and poor survival compared with localized skin cancers. Our goal was to investigate multimodal therapy for lymph-node-positive NMSC. Data from patients with lymph-node-positive NMSC who underwent surgery and adjuvant therapy at a single tertiary center from 2002 to 2012 were retrospectively reviewed. Median follow-up was 1.8 years (range: 0.5 to 8.5). Overall survival (OS) and progression-free survival (PFS) were calculated using the Kaplan-Meier method...
July 2017: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/28712661/managing-incidentalomas-safely-do-computed-tomography-requisitions-tell-us-what-we-need-to-know
#16
Matthew Walker, Joy Borgaonkar, Daria Manos
PURPOSE: Technological advancements and the ever-increasing use of computed tomography (CT) have greatly increased the detection of incidental findings, including tiny pulmonary nodules. The management of many "incidentalomas" is significantly influenced by a patient's history of cancer. The study aim is to determine if CT requisitions include prior history of malignancy. METHODS: Requisitions for chest CTs performed at our adult tertiary care hospital during April 2012 were compared to a cancer history questionnaire, administered to patients at the time of CT scan...
July 13, 2017: Canadian Association of Radiologists Journal, Journal L'Association Canadienne des Radiologistes
https://www.readbyqxmd.com/read/28704830/sirtuins-in-skin-and-skin-cancers
#17
Liz Mariely Garcia-Peterson, Melissa Jean Wilking-Busch, Mary Ann Ndiaye, Christine Gaby Azer Philippe, Vijayasaradhi Setaluri, Nihal Ahmad
The sirtuins are a family of proteins that comprise class III of the histone deacetylases. These NAD+-dependent proteins have been found to be intricately involved in a variety of important and skin-relevant cellular functions and processes, including aging, UV damage response, oxidative stress, and wound repair. In addition, recent research is unraveling the role of sirtuins in a variety of skin diseases, including melanoma and nonmelanoma skin cancers. In this review, we provide a discussion on the potential roles and implications of different sirtuins in skin-specific cellular processes, which may have relevance to skin health and skin diseases...
2017: Skin Pharmacology and Physiology
https://www.readbyqxmd.com/read/28700773/association-of-multiple-primary-skin-cancers-with-human-immunodeficiency-virus-infection-cd4-count-and-viral-load
#18
Maryam M Asgari, G Thomas Ray, Charles P Quesenberry, Kenneth A Katz, Michael J Silverberg
Importance: Persons with human immunodeficiency virus (HIV) have a 2.8-fold higher risk than HIV-uninfected persons of nonmelanoma skin cancer (NMSC), defined as basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). Individuals with a prior NMSC history are at increased risk for subsequent NMSC, but the magnitude of risk and its relation to HIV disease-related factors, including CD4 count and viral load (VL), are unknown. Objective: To better understand how laboratory markers currently used to evaluate HIV disease progression may be associated with subsequent NMSC risk...
September 1, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28681396/association-of-atopy-and-tentative-diagnosis-of-skin-cancer-results-from-occupational-skin-cancer-screenings
#19
I Schäfer, P Mohr, N Zander, R Fölster-Holst, M Augustin
BACKGROUND: The relationship between atopic conditions and carcinoma of the skin has been described inconsistently. Population-based data providing information on atopic diseases as well as on skin cancer are sparse. OBJECTIVE: To determine the correlation between atopy and prevalence of precanceroses, non-melanoma skin cancer and malignant melanoma (MM), while taking into account known risk factors for skin cancer. METHODS: Data from occupational skin cancer screenings were analysed in a cross-sectional study...
July 6, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28676156/anatomy-of-the-skin-and-the-pathogenesis-of-nonmelanoma-skin-cancer
#20
REVIEW
William D Losquadro
Skin is composed of the epidermis, dermis, and adnexal structures. The epidermis is composed of 4 layers-the stratums basale, spinosum, granulosum, and corneum. The dermis is divided into a superficial papillary dermis and deeper reticular dermis. Collagen and elastin within the reticular dermis are responsible for skin tensile strength and elasticity, respectively. The 2 most common kinds of nonmelanoma skin cancers are basal cell and squamous cell carcinoma. Both are caused by a host of environmental and genetic factors, although UV light exposure is the single greatest predisposing factor...
August 2017: Facial Plastic Surgery Clinics of North America
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