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https://www.readbyqxmd.com/read/29160902/proportion-and-number-of-cancer-cases-and-deaths-attributable-to-potentially-modifiable-risk-factors-in-the-united-states
#1
Farhad Islami, Ann Goding Sauer, Kimberly D Miller, Rebecca L Siegel, Stacey A Fedewa, Eric J Jacobs, Marjorie L McCullough, Alpa V Patel, Jiemin Ma, Isabelle Soerjomataram, W Dana Flanders, Otis W Brawley, Susan M Gapstur, Ahmedin Jemal
Contemporary information on the fraction of cancers that potentially could be prevented is useful for priority setting in cancer prevention and control. Herein, the authors estimate the proportion and number of invasive cancer cases and deaths, overall (excluding nonmelanoma skin cancers) and for 26 cancer types, in adults aged 30 years and older in the United States in 2014, that were attributable to major, potentially modifiable exposures (cigarette smoking; secondhand smoke; excess body weight; alcohol intake; consumption of red and processed meat; low consumption of fruits/vegetables, dietary fiber, and dietary calcium; physical inactivity; ultraviolet radiation; and 6 cancer-associated infections)...
November 21, 2017: CA: a Cancer Journal for Clinicians
https://www.readbyqxmd.com/read/29133634/immunohistochemical-expression-of-x-linked-inhibitor-of-apoptosis-in-eyelid-sebaceous-gland-carcinoma-predicts-a-worse-prognosis
#2
Perumal Jayaraj, Seema Sen, P S Dhanaraj, Romika Jhajhria, Shalu Singh, Vijay Kumar Singh
PURPOSE: Overexpression of the inhibitors of apoptosis proteins have been demonstrated in a variety and of solid tumors including melanomas and nonmelanomas skin cancers. X-linked inhibitor of apoptosis protein (XIAP) is an inhibitor of apoptosis which prevents apoptosis by inhibiting caspases 9, 7, and 3. The prognostic value of XIAP in sebaceous gland carcinoma (SGC) remains unexplored. METHODS: The immunohistochemical expression of XIAP was evaluated in 29 SGC cases...
November 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29130624/efficiency-of-electrochemotherapy-with-reduced-bleomycin-dose-in-the-treatment-of-nonmelanoma-head-and-neck-skin-cancer-preliminary-results
#3
Ales Groselj, Masa Bosnjak, Primoz Strojan, Mojca Krzan, Maja Cemazar, Gregor Sersa
BACKGROUND: In the present study, effectiveness of electrochemotherapy was compared in patients with nonmelanoma skin cancer (NMSC) of the head and neck using standard and reduced doses of bleomycin. METHODS: Twenty-eight patients older than 65 years were prospectively treated with electrochemotherapy for nonmelanoma head and neck skin cancer. In the experimental group (n = 12 patients; 24 lesions), reduced bleomycin doses (10 000 IU/m(2) ) were used. In the control group (n = 16 patients; 28 lesions), the standard bleomycin doses (15 000 IU/m(2) ) were used...
November 11, 2017: Head & Neck
https://www.readbyqxmd.com/read/29119028/erosive-pustular-dermatosis-of-the-scalp-with-urate-like-crystals
#4
Patrick O Emanuel, Sharad P Paul
Follicular urate-like crystals were first described in Necrotizing Infundibular Crystalline Folliculitis (NICF), a rare cutaneous disorder with multiple waxy folliculocentric papules. Similar crystal accumulation may be seen within follicular infundibulae as an incidental finding. We describe a case showing identical crystals occurring within the horn-like crusts of a patient with erosive pustular dermatosis of the scalp (EPDS), a condition which due to its presentation can often be mistaken for nonmelanoma skin cancer...
2017: Case Reports in Dermatological Medicine
https://www.readbyqxmd.com/read/29117359/co-occurring-genomic-alterations-and-association-with-progression-free-survival-in-brafv600-mutated-nonmelanoma-tumors
#5
Shiraj Sen, Funda Meric-Bernstam, David S Hong, Kenneth R Hess, Vivek Subbiah
BRAFV600 mutations occur in multiple nonmelanoma tumors, but no US Food and Drug Administration-approved BRAF-targeted therapies exist for these cancers. BRAF inhibitor vemurafenib was recently found to demonstrate activity across various BRAF-mutated nonmelanoma cancer types. However, most tumors ultimately become resistant to BRAF-targeted monotherapy. To identify whether co-occurring genomic alterations drive resistance to BRAF-targeted therapies, we analyzed next-generation sequencing data from 30 advanced BRAF-mutated nonmelanoma cancers treated with BRAF inhibitor monotherapy...
October 1, 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29117315/interdisciplinary-perspectives-on-sun-safety
#6
Alan C Geller, Nina G Jablonski, Sherry L Pagoto, Jennifer L Hay, Joel Hillhouse, David B Buller, W Larry Kenney, June K Robinson, Richard B Weller, Megan A Moreno, Barbara A Gilchrest, Craig Sinclair, Jamie Arndt, Jennifer M Taber, Kasey L Morris, Laura A Dwyer, Frank M Perna, William M P Klein, Jerry Suls
Overexposure to the sun is associated with an increased risk of melanoma and nonmelanoma skin cancer, but indications of improvements in sun protection behavior are poor. Attempts to identify emerging themes in skin cancer control have largely been driven by groups of experts from a single field. In December 2016, 19 experts from various disciplines convened for Interdisciplinary Perspectives on Skin Cancer, a 2-day meeting hosted by the National Academy of Sciences. The group discussed knowledge gaps, perspectives on sun exposure, implications for skin cancer risk and other health outcomes, and new directions...
November 8, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/29106018/quality-of-life-assessment-in-patients-with-nonmelanoma-skin-cancer-psychometric-validation-of-the-eortc-qlq-c30-questionnaire
#7
Karolina Müller, Sigrid Karrer, Rolf-Markus Szeimies, Julia Steinbauer, Elisabeth Kohl, Dominik Steinbauer, Florian Zeman, Mark Berneburg, Michael Koller
BACKGROUND: Nonmelanoma skin cancer (NMSC) is a chronic and sometimes difficult-to-treat condition affecting the quality of life (QL). The present study was conducted to investigate whether the European Organization for Research and Treatment of Cancer (EORTC) core QL Questionnaire - Cancer (QLQ-C30) is a suitable tool for the assessment of QL in patients with NMSC. PATIENTS AND METHODS: In order to define the psychometric properties of the questionnaire, the QLQ-C30 and the Dermatology Life Quality Index (DLQI) were handed out to 172 patients of the Department of Dermatology at the University Hospital Regensburg, Germany...
November 2017: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/29103328/skin-cancer-associated-with-commonly-prescribed-drugs-tumor-necrosis-factor-alpha-inhibitors-tnf-%C3%AE-is-angiotensin-receptor-blockers-arbs-phosphodiesterase-type-5-inhibitors-pde5is-and-statins-weighing-the-evidence
#8
Beatrice Nardone, Kelsey A Orrell, Paras P Vakharia, Dennis P West
Skin cancers, including both malignant melanoma (MM) and nonmelanoma skin cancer (NMSC), are the most commonly diagnosed cancers in the US. The incidence of both MM and NMSC continues to rise. Areas Covered: Current evidence for an association between four of the most commonly prescribed classes of drugs in the U.S. and risk for MM and NMSC is reported. Medline was searched (January 2000 to May 2017) for each drug in the classes and for "basal cell carcinoma", "squamous cell carcinoma", "non-melanoma skin cancer", "skin cancer" and "melanoma"...
November 6, 2017: Expert Opinion on Drug Safety
https://www.readbyqxmd.com/read/29066323/correlation-between-incisional-biopsy-histological-subtype-and-a-mohs-surgery-specimen-for-nonmelanoma-skin-cancer
#9
E C Cortés-Peralta, J Ocampo-Candiani, O T Vázquez-Martínez, I M Gutiérrez-Villarreal, I Miranda-Maldonado, V Garza-Rodríguez
BACKGROUND: Histological diagnosis of a clinically suspected nonmelanoma skin cancer (NMSC) is recommended before treatment. For NMSC, concordance between the histological subtype of the preoperative biopsy and the excision specimen of basal cell carcinoma (BCC) has been reported to range from 10% to 81%. No large study on the concordance between NMSC histology seen in a preoperative biopsy with the following tumour specimen from Mohs micrographic surgery (MMS) has been performed in a Latin American population...
October 21, 2017: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/29057176/the-effect-of-conversion-from-a-calcineurin-inhibitor-to-sirolimus-on-skin-cancer-reduction-in-post-renal-transplantation-patients
#10
REVIEW
Aaron Smith, Wei Niu, Anand Desai
In kidney transplant patients, skin cancer is the most commonly involved neoplasm. More than 90% of post-transplantation skin cancers are nonmelanoma skin cancers (NMSCs). The majority of them are squamous cell carcinomas and basal cell carcinomas. Calcineurin inhibitors (CNIs) such as cyclosporine and tacrolimus are immunosuppressive agents given after solid organ transplantation, but they can also promote tumor growth. Sirolimus is a novel class of immunosuppressants and has been proven to have antineoplastic properties...
August 13, 2017: Curēus
https://www.readbyqxmd.com/read/29056075/an-updated-review-of-the-jak1-2-inhibitor-ruxolitininb-in-the-philadelphia-negative-myeloproliferative-neoplasms
#11
Natalia Curto-Garcia, Claire N Harrison
Ruxolitinib (Rux), a JAK1/2 inhibitor, has been approved for patients with myelofibrosis and in polycythemia vera with inadequate response/intolerance to hydroxycarbamide. Studies have demonstrated that Rux improves disease-related symptoms and splenomegaly. A late emerging observation from two Phase III trials was that Rux was associated with survival advantage in comparison with placebo or other available therapies in myelofibrosis. Important data suggest that for polycythemia vera Rux improved control of blood counts...
October 23, 2017: Future Oncology
https://www.readbyqxmd.com/read/29044731/nicotinamide-for-prevention-of-nonmelanoma-skin-cancers-a-change-in-practice
#12
L Nestor, J Clowry, K Molloy, M Connolly, A Salim, A M Tobin
No abstract text is available yet for this article.
October 16, 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/29036262/granuloma-annulare-secondary-to-vemurafenib-therapy-for-lung-adenocarcinoma
#13
Helena A Jenkinson, Alan E Siroy, Adrienne Choksi
Numerous cutaneous manifestations have been associated with use of BRAF inhibitors, including two previously reported cases of granuloma annulare (GA) eruptions associated with vemurafenib therapy. Both of these patients were being treated for metastatic melanoma. In this report, we describe the case of a 71-year-old man who developed classic GA lesions while being treated with vemurafenib monotherapy for nonmelanoma cancer, specifically metastatic lung adenocarcinoma positive for BRAF V600 mutation. <p><em>J Drugs Dermatol...
October 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28991855/cancer-risk-in-2621-chinese-patients-with-inflammatory-bowel-disease-a-population-based-cohort-study
#14
Jacqueline So, Whitney Tang, Wai Keung Leung, Michael Li, Fu Hang Lo, Marc T L Wong, Alex Shun Fung Sze, Chi Man Leung, Steven Woon Choy Tsang, Edwin Hok Shing Shan, Kam Hon Chan, Belsy C Y Lam, Aric J Hui, Wai Hung Chow, Tsz Yiu Lam, Vernon Lam, Tsz Wai Lee, Harris Ho Him Lo, Ching Man Tang, Cheuk Lau Wong, Justin C Y Wu, Francis K L Chan, Joseph J Y Sung, Marcus Harbord, Siew C Ng
BACKGROUND: Studies on cancer risk in inflammatory bowel disease (IBD) have yielded inconsistent results. We conducted a population-based study to determine the risk of cancer in patients with Crohn's disease (CD) and ulcerative colitis (UC). METHODS: Using a territory-wide IBD registry in Hong Kong, we identified 2621 patients with IBD and no history of cancer from 1990 to 2016. We followed them from diagnosis until either September 2016, cancer development, proctocolectomy, or death...
November 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28979658/radiation-therapy-for-the-adjunctive-treatment-of-surgically-excised-keloids-a-review
#15
REVIEW
Nikoo Cheraghi, Armand Cognetta, David Goldberg
BACKGROUND: Radiotherapy has been used historically to treat a wide variety of dermatologie conditions, including nonmelanoma skin cancers, lymphomas, and inflammatory skin conditions. Recently, radiotherapy has been used increasingly as a valuable tool in the postsurgical treatment of large or recalcitrant keloids. OBJECTIVE: The objective of this review was to explore the use of radiation therapy as an adjuvant to surgically excised keloids. DESIGN: A PubMed search of all published English literature regarding the applications of radiotherapy for the treatment of keloids was performed using a combination of keywords including radiation, radiotherapy, brachytherapy, electron beam, superficial radiation, orthovoltage radiation, and keloid...
August 2017: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/28960648/second-primary-cancer-after-major-salivary-gland-carcinoma
#16
Karoliina Hirvonen, Matti Rantanen, Aaro Haapaniemi, Janne Pitkäniemi, Nea Malila, Antti A Mäkitie
BACKGROUND: We investigated the risk of second primary cancers after major salivary gland carcinoma in Finland, with a population of 5.5 million. METHODS: Nationwide cancer registry data were used to identify patients with major salivary gland carcinoma diagnosed between 1953 and 2014. Standardized incidence ratios (SIRs) were estimated to compare their second primary cancer risk with the respective site-specific cancer risk in the general population. RESULTS: There were 1727 patients with major salivary gland carcinomas and 222 second primary cancers had been diagnosed in these patients (SIR 1...
September 29, 2017: Head & Neck
https://www.readbyqxmd.com/read/28957961/antineutrophil-cytoplasmic-antibody-associated-vasculitis-and-malignancy
#17
Maria A C Wester Trejo, Ingeborg M Bajema, Emma E van Daalen
PURPOSE OF REVIEW: Patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) have an increased malignancy risk compared with the general population. This review aims to evaluate recent evidence for changes in the incidence of malignancy in patients with AAV and to examine explanations for the association between AAV and malignancy. RECENT FINDINGS: The overall malignancy risk in patients with AAV has decreased, most likely as a result of recent changes in therapeutic regimen, that is, a decrease in the exposure to cyclophosphamide...
September 27, 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/28947282/diagnostic-accuracy-of-teledermatology-for-nonmelanoma-skin-cancer-can-patients-be-referred-directly-for-surgical-management
#18
Maren E Cotes, Lauren N Albers, Michael Sargen, Suephy C Chen
No abstract text is available yet for this article.
September 22, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28940277/evidence-for-an-association-between-alcohol-intake-and-an-increased-risk-of-nonmelanoma-skin-cancer
#19
COMMENT
M Rota
No abstract text is available yet for this article.
September 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28893407/risk-of-malignancy-with-systemic-psoriasis-treatment-in-the-psoriasis-longitudinal-assessment-registry
#20
David Fiorentino, Vincent Ho, Mark G Lebwohl, Luiz Leite, Lori Hopkins, Claudia Galindo, Kavitha Goyal, Wayne Langholff, Steven Fakharzadeh, Bhaskar Srivastava, Richard G Langley
BACKGROUND: The effect of systemic therapy on malignancy risk among patients with psoriasis is not fully understood. OBJECTIVE: Evaluate the impact of systemic treatment on malignancy risk among patients with psoriasis in the Psoriasis Longitudinal Assessment and Registry (PSOLAR). METHODS: Nested case-control analyses were performed among patients with no history of malignancy. Cases were defined as first malignancy (other than nonmelanoma skin cancer) in the Psoriasis Longitudinal Assessment and Registry, and controls were matched by age, sex, geographic region, and time on registry...
November 2017: Journal of the American Academy of Dermatology
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