keyword
https://read.qxmd.com/read/38451070/influence-of-the-gut-and-airway-microbiome-on-asthma-development-and-disease
#1
REVIEW
Tamar Smulders, Marc P Van Der Schee, Anke H Maitland-Van Der Zee, Frederik G Dikkers, Cornelis M Van Drunen
There are ample data to suggest that early-life dysbiosis of both the gut and/or airway microbiome can predispose a child to develop along a trajectory toward asthma. Although individual studies show clear associations between dysbiosis and asthma development, it is less clear what (collection of) bacterial species is mechanistically responsible for the observed effects. This is partly due to issues related to the asthma diagnosis and the broad spectrum of anatomical sites, sample techniques, and analysis protocols that are used in different studies...
March 2024: Pediatric Allergy and Immunology
https://read.qxmd.com/read/38422259/production-of-a-ric-c3-hypo-allergen-with-no-ige-binding-or-anaphylactogenic-activity
#2
JOURNAL ARTICLE
M G B Bartholazzi, T M Lodi, E S Mello, A O Carvalho, B C B Beirão, O L T Machado
Several studies have been carried out to expand the use of Ricinus communis L. castor bean (Ricinus communis L castor bean.). This oilseed finds appropriate conditions for its development in Brazil, with more than 700 applications. The main allergens of this plant are Ric c1 and Ric c3, that cross-react with various aeroallergens and food allergens such as peanuts, soybeans, corn, and wheat. This study aimed to determine the effect of mutations in Ric c3 amino acid residues known to affect IgE binding and allergy challenges...
2024: Brazilian Journal of Biology
https://read.qxmd.com/read/38409905/corn-dependent-exercise-induced-anaphylaxis-with-cross-antigenicity-to-avocado
#3
JOURNAL ARTICLE
Yuri Takaoka, Nayu Sato, Masashi Nakamura, Kayoko Matsunaga, Amane Shigekawa, Makoto Kameda
No abstract text is available yet for this article.
2024: Pediatrics International: Official Journal of the Japan Pediatric Society
https://read.qxmd.com/read/38158046/evaluation-of-elisa-test-kits-for-detection-of-milk-protein-in-frying-oil-treated-at-different-temperatures
#4
JOURNAL ARTICLE
Yingshuang Lu, Tong-Jen Fu
Milk is a common ingredient in fried foods. Allergen cross-contact can occur through reuse of frying oil. To enable assessment of the allergy risk of reused oil, methods for quantification of milk protein in oil are needed. This study evaluated four commercial ELISA test kits in comparison with the 660 nm total protein assay for detection of milk protein in oil after frying. Corn oil spiked with nonfat or whole milk powder were fried at 150°C or 180°C for 3 min and were analyzed by ELISA kits either directly or after pre-extraction with phosphate-buffered saline containing 0...
December 27, 2023: Journal of Food Protection
https://read.qxmd.com/read/37763228/allergic-proctocolitis-literature-review-and-proposal-of-a-diagnostic-therapeutic-algorithm
#5
REVIEW
Simona Barni, Francesca Mori, Mattia Giovannini, Lucia Liotti, Carla Mastrorilli, Luca Pecoraro, Francesca Saretta, Riccardo Castagnoli, Stefania Arasi, Lucia Caminiti, Mariannita Gelsomino, Angela Klain, Michele Miraglia Del Giudice, Elio Novembre
Allergic proctocolitis (AP) is a benign condition, frequent in childhood, that is classified as a non-IgE-mediated food allergy. The prevalence is unknown; however, its frequency appears to be increasing, especially in exclusively breastfed infants. Clinical manifestations typically begin in the first few months of life with the appearance of bright red blood (hematochezia), with or without mucus, in the stool of apparently healthy, thriving infants. Most cases of AP are caused by cow's milk proteins; however, other allergens, such as soy, egg, corn, and wheat, may be potential triggers...
August 29, 2023: Life
https://read.qxmd.com/read/37705461/inflammatory-innate-lymphoid-cells-predict-response-speed-to-dupilumab-in-chronic-rhinosinusitis-with-nasal-polyps
#6
JOURNAL ARTICLE
Korneliusz Golebski, Rik Johannes Leonardus van der Lans, Danielle van Egmond, Esther de Groot, Hergen Spits, Anke-Hilse Maitland-van der Zee, Cornelis Maria van Drunen, Wytske Johanna Fokkens, Sietze Reitsma
No abstract text is available yet for this article.
September 14, 2023: Allergy
https://read.qxmd.com/read/37649109/high-excess-free-fructose-beverage-consumption-is-not-associated-with-prevalent-allergy-in-us-adults-a-population-based-analysis-of-nhanes-2005-2006
#7
JOURNAL ARTICLE
Ruili Yu, Lili Cai, Bo Yang
BACKGROUND: A strong association exists between high-excess free fructose (EFF) beverage consumption and prevalent allergy in children and adolescents; however, whether this association exists in the adult population is unclear. Therefore, this study aimed to investigate the relationship between high-EFF beverage intake and prevalent allergy. METHODS: This cross-sectional study extracted data from the National Health and Nutrition Examination Survey 2005-2006. Adults aged ≥ 20 were eligible for inclusion, excluding those without complete information on beverage intake, allergic symptom survey, and allergen-specific immunoglobulin E test results...
August 30, 2023: Journal of Health, Population, and Nutrition
https://read.qxmd.com/read/37633241/nesfatin-1-regulates-the-hmgb1-tlr4-nf-%C3%AE%C2%BAb-signaling-pathway-to-inhibit-inflammation-and-its-effects-on-the-random-skin-flap-survival-in-rats
#8
JOURNAL ARTICLE
Zhikai Jiang, Kaitao Wang, Yuting Lin, Taotao Zhou, Yi Lin, Jianpeng Chen, Qicheng Lan, Zhefeng Meng, Xuao Liu, Hang Lin, Dingsheng Lin
OBJECTIVE: Random skin flaps are often placed by plastic surgeons to treat limb deformities and dysfunction. Nesfatin-1 (NES) is a peptide that exerts angiogenic, anti-inflammatory, and anti-oxidant effects. We assessed the impact of NES on flap survival and the underlying mechanism. METHODS: We modified the McFarlane random skin flap rat model. Thirty-six male Sprague-Dawley rats were randomly divided into a control group (corn oil solution with DMSO), low-dose group (NES-L at 10 µg/kg/day), and high-dose group (NES-H at 20 µg/kg/day)...
August 24, 2023: International Immunopharmacology
https://read.qxmd.com/read/37605554/difference-in-respiratory-syncytial-virus-specific-fc-mediated-antibody-effector-functions-between-children-and-adults
#9
JOURNAL ARTICLE
Anke J Lakerveld, Anne T Gelderloos, Rutger M Schepp, Cornelis A M de Haan, Robert S van Binnendijk, Nynke Y Rots, Josine van Beek, Cécile A C M van Els, Puck B van Kasteren
Respiratory syncytial virus (RSV) infections are a major cause of bronchiolitis and pneumonia in infants and older adults, for which there is no known correlate of protection. Increasing evidence suggests that Fc-mediated antibody effector functions have an important role, but little is known about the development, heterogeneity, and durability of these functional responses. In light of future vaccine strategies, a clear view of the immunological background and differences between various target populations is of crucial importance...
August 22, 2023: Clinical and Experimental Immunology
https://read.qxmd.com/read/37454339/an-international-survey-of-allogeneic-hematopoietic-cell-transplantation-for-x-linked-agammaglobulinemia
#10
JOURNAL ARTICLE
Akira Nishimura, Ramya Uppuluri, Revathi Raj, Venkateswaran Vellaichamy Swaminathan, Yifei Cheng, Rolla F Abu-Arja, Bin Fu, Alexandra Laberko, Michael H Albert, Fabian Hauck, Giorgia Bucciol, Venetia Bigley, Suzanne Elcombe, Gaurav Kharya, Cornelis Jan H Pronk, Claudia Wehr, Bénédicte Neven, Klaus Warnatz, Isabelle Meyts, Tomohiro Morio, Andrew R Gennery, Hirokazu Kanegane
PURPOSE: X-linked agammaglobulinemia (XLA) is an inborn error of immunity caused by variants in Bruton's tyrosine kinase (BTK). XLA patients require lifelong immunoglobulin replacement therapy (IgRT). Only few XLA patients are indicated for allogeneic hematopoietic cell transplantation (HCT) because of severe complications. Accordingly, the published transplantation experience in XLA is minimal. We aimed to collect clinical data of XLA patients who received HCT in an international framework and to establish appropriate transplantation criteria and methods for XLA patients...
July 16, 2023: Journal of Clinical Immunology
https://read.qxmd.com/read/37402353/a-pilot-study-to-identify-grass-species-that-mediate-pollen-allergy-in-thailand
#11
JOURNAL ARTICLE
Pakawat Jarupund, Prayoon Jantrakulroj, Chalermpol Suwanphakdee, Chomdao Sinthuvanich
INTRODUCTION: Some grass species that are either common or widely spread in Thailand have not been used for pollen allergy diagnosis. In order to improve diagnostic accuracy, the aim of this pilot study was to identify the grass species responsible for pollen allergy in Thailand. METHODS: The skin sensitization of pollen extracts from six different grass species, including rice (Oryza sativa), corn (Zea mays), sorghum (Sorghum bicolor), para grass (Urochloa mutica), ruzi grass (Urochloa eminii), and green panic grass (Megathyrsus maximus), was evaluated by skin prick test (SPT)...
July 4, 2023: International Archives of Allergy and Immunology
https://read.qxmd.com/read/36898761/bystander-activation-of-tissue-resident-memory-cd4-t-cells-getting-by-with-a-little-help-from-unfamiliar-t-cell-friends
#12
JOURNAL ARTICLE
Rebecca Cornelis, Ziv Shulman
Reexposure to a pathogen triggers the activation of memory T cells that have already encountered a similar microbe. These long-lived CD4 T cells either circulate through the blood and tissues or reside within organs and are referred to as tissue-resident T cells (CD4 TRM ). In the current issue of the European Journal of Immunology[Eur. J. Immunol. 2023.53:xxxx-xxxxx] issue, Curham et al. found that tissue-resident memory CD4 T cells in the lung and nasal tissues can respond to non-cognate immune challenges...
March 10, 2023: European Journal of Immunology
https://read.qxmd.com/read/36780000/combination-immunotherapy-with-synthetic-long-peptides-and-chemotherapy-or-pd-1-blocker-for-cancers-caused-by-human-papilloma-virus-type-16
#13
REVIEW
Cornelis J M Melief, Esmé van der Gracht, Anna-Sophia Wiekmeijer
Therapeutic vaccination of premalignant conditions and of different stages of cancer can be accomplished with several platforms including DNA vaccines, RNA vaccines, synthetic long peptides (SLP), and recombinant viruses. We successfully used a therapeutic vaccine composed of SLP covering the complete sequence of the two oncogenic proteins E6 and E7 of human papillomavirus type 16 (HPV16) as monotherapy in patients with premalignant disease. However, combination treatment might be required in patients with (advanced) cancer because of the hostile cancer microenvironment for T cells in established HPV16+ cancer, often associated with systemic immunosuppression...
February 13, 2023: Seminars in Immunopathology
https://read.qxmd.com/read/36438166/formulation-of-vermicelli-mixed-corn-and-rice-flour-with-additional-carrageenan-and-its-economic-value
#14
JOURNAL ARTICLE
Moh Saeri, Joko Mariyono, Evy Latifah, Aniswatul Khamidah, Ita Yustina, Sugiono Sugiono, Khojin Supriadi, Herman Subagio, Sri Satya Antarlina
The study was aimed at obtaining a vermicelli formulation on a mixture of corn and rice flour, adding carrageenan and its economic analysis. The experiment applied a 2-factorial randomized block design, where factor 1 was a mixture of corn and rice flour (5 levels) and factor 2 was carrageenan concentration (5 levels), repeated three times. The data were analyzed using ANOVA provided in SPSS. When there were significant differences, the analysis proceeded with DMRT at a level of 5% to see differences among treatments...
2022: International Journal of Food Science
https://read.qxmd.com/read/36351370/upper-airway-and-brain-protection-by-plasma-cells-a-local-affair
#15
JOURNAL ARTICLE
Rebecca Cornelis, Ziv Shulman
Protecting the upper airways and brain from viral invasion through the olfactory mucosa is critical. Wellford et al. describe a barrier that restricts the passage of circulating antibodies and prevents them from reaching the olfactory mucosa. Instead, plasma cells are recruited into this site and prevent viral infection of the airways and the brain through local antibody production.
November 8, 2022: Immunity
https://read.qxmd.com/read/36313853/detecting-common-allergens-in-dogs-with-atopic-dermatitis-in-south-korean-provinces-using-a-serological-immunoglobulin-e-specific-allergen-test
#16
JOURNAL ARTICLE
Gareeballah Osman Adam, Yang-Gyu Park, Jeong-Hwi Cho, Jinyoung Choi, Hong-Geun Oh
Background and Aim: Canine atopic dermatitis (CAD) is a hereditary susceptibility to the development of allergic symptoms in response to repeated exposure to generally innocuous substances known as "allergens." Allergens can be plants, animals, mold, mites, or milk. At present, serological enzyme-linked immunoassay (ELISA) kits are used for immunoglobulin E (IgE)-specific allergen detection due to their simplicity and accuracy. This study aimed to detect allergens in dogs with CAD and determine how they differ according to season, breed, age, and sex using a serological test in six provinces in South Korea for 12 months...
August 2022: Veterinary World
https://read.qxmd.com/read/36067905/novel-model-for-chronic-intestinal-inflammation-in-chickens-2-immunologic-mechanism-behind-the-inflammatory-response
#17
JOURNAL ARTICLE
Gabriela C Dal Pont, A Lee, C Bortoluzzi, Y Z Farnell, C Gougoulias, M H Kogut
Intestinal inflammation in poultry is a complex response that involves immune and intestinal cells which is still not fully understood. Thus, to better understand the mechanisms that drive the chronic intestinal inflammation in fowl we conducted an experiment applying a previously established nutritional model of low-grade chronic intestinal inflammation to evaluate cytokine and chemokine profiles in the chicken intestine. For this, we placed 90 one-day chickens into two treatments: (1) a control group (CNT) fed a corn-soybean diet, and (2) a group fed a diet high in non-starch polysaccharides (NSP)...
September 3, 2022: Developmental and Comparative Immunology
https://read.qxmd.com/read/35985324/the-pre-exposure-sars-cov-2-specific-t-cell-repertoire-determines-the-quality-of-the-immune-response-to-vaccination
#18
JOURNAL ARTICLE
Carina Saggau, Gabriela Rios Martini, Elisa Rosati, Silja Meise, Berith Messner, Ann-Kristin Kamps, Nicole Bekel, Johannes Gigla, Ruben Rose, Mathias Voß, Ulf M Geisen, Hayley M Reid, Melike Sümbül, Florian Tran, Dennis K Berner, Yascha Khodamoradi, Maria J G T Vehreschild, Oliver Cornely, Philipp Koehler, Andi Krumbholz, Helmut Fickenscher, Oliver Kreuzer, Claudia Schreiber, Andre Franke, Stefan Schreiber, Bimba Hoyer, Alexander Scheffold, Petra Bacher
SARS-CoV-2 infection and vaccination generates enormous host-response heterogeneity and an age-dependent loss of immune-response quality. How the pre-exposure T cell repertoire contributes to this heterogeneity is poorly understood. We combined analysis of SARS-CoV-2-specific CD4+ T cells pre- and post-vaccination with longitudinal T cell receptor tracking. We identified strong pre-exposure T cell variability that correlated with subsequent immune-response quality and age. High-quality responses, defined by strong expansion of high-avidity spike-specific T cells, high interleukin-21 production, and specific immunoglobulin G, depended on an intact naive repertoire and exclusion of pre-existing memory T cells...
August 12, 2022: Immunity
https://read.qxmd.com/read/35811287/prevalence-clinical-presentation-and-associated-atopic-diseases-of-pediatric-fruit-and-vegetable-allergy-a-population-based-study
#19
JOURNAL ARTICLE
Shih-Kuan Li, Zheying Liu, Chih-Kang Huang, Tzee-Chung Wu, Ching-Feng Huang
BACKGROUND: In children, fruit and vegetable allergies are often overlooked compared with well-known allergies such as those to eggs, milk, and shellfish. Therefore, this study aimed to analyze fruit and vegetable allergies in children, including prevalence, types of food allergens, clinical presentation, management, and associated comorbid atopic diseases. METHODS: In 2012, a nationwide, cross-sectional, random sampling questionnaire-based survey for common fruit and vegetable allergies was conducted in Taiwan...
June 22, 2022: Pediatrics and Neonatology
https://read.qxmd.com/read/35533555/high-fructose-corn-syrup-promotes-proinflammatory-macrophage-activation-via-ros-mediated-nf-%C3%AE%C2%BAb-signaling-and-exacerbates-colitis-in-mice
#20
JOURNAL ARTICLE
Liping Wang, Tiantian Ji, Ye Yuan, Haoyu Fu, Yang Wang, Shaobo Tian, Jia Hu, Lin Wang, Zheng Wang
The dramatically increasing incidence and prevalence of inflammatory bowel disease (IBD) are reportedly related to a Western diet, which is characterized by high sugar consumption. Dietary simple sugars aggravate IBD in animal models. However, the mechanisms underlying this effect remain unclear. Given that high-fructose corn syrup (HFCS) is a major added sugar in food and beverages, we focus on HFCS and investigated the effects of HFCS on a dextran sulfate sodium (DSS)-induced murine colitis model and in RAW264...
August 2022: International Immunopharmacology
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