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nerve conduction velocity

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https://www.readbyqxmd.com/read/29457605/negative-pressure-therapy-in-the-regeneration-of-the-sciatic-nerve-using-vacuum-assisted-closure-in-a-rabbit-model
#1
Jian-Ping Wu, Zhen-Huan Jiang, Xiao-Jun Feng, Jian-Nong Jiang, Mao-Hua Cheng
BACKGROUND The aim of this study was to investigate the effects of negative pressure therapy in the regeneration of the rabbit sciatic nerve using vacuum assisted closure (VAC). MATERIAL AND METHODS Thirty male New Zealand white rabbits underwent surgical injury of the sciatic nerve, followed by negative pressure therapy using vacuum assisted closure (VAC), in three treatment groups: Group A: 0 kPa; Group B: -20 kPa; Group C: -40 kPa. At 12 weeks following surgery, the following factors were studied: motor nerve conduction velocity (MNCV); the number of myelinated nerve fibers; the wet weight of the gastrocnemius muscle...
February 19, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29456810/minocycline-through-attenuation-of-oxidative-stress-and-inflammatory-response-reduces-the-neuropathic-pain-in-a-rat-model-of-chronic-constriction-injury
#2
Abolfazl Abbaszadeh, Saeideh Darabi, Amin Hasanvand, Hossein Amini-Khoei, Amir Abbasnezhad, Razieh Choghakhori, Asghar Aaliehpour
Objectives: Several lines of evidence showed that minocycline possesses antioxidant and anti-inflammatory properties. This study aimed to demonstrate the effects of minocycline in rats subjected to chronic constriction injury (CCI). Materials and Methods: In this study four groups (n = 6-8) of rats were used as follows: Sham, CCI, CCI + minocycline (MIN) 10 mg/Kg (IP) and CCI + MIN 30 mg/Kg (IP). On days 3, 7, 14, and 21 post-surgery hot-plate, acetone, and von Frey tests were carried out...
February 2018: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29456354/impact-of-aging-on-nerve-conduction-velocities-and-late-responses-in-healthy-individuals
#3
Suchitra Sachin Palve, Sachin Bhaskar Palve
Background: Nerve conduction studies are performed to diagnose the disorders of the peripheral nervous system. The reference values for nerve conduction velocity (NCV) and late responses for different nerves considerably vary in different group and type of population. Physiological factors such as age, temperature, height, and gender affect the NCV. However, there are very few studies which show the age group at which these changes become significant. Aim and Objectives: The aim of the study was to establish the electrophysiological data of the specific age group at which changes in NCV as well as late responses of median common peroneal nerve and also see the late response in the form of F-waves and H-reflex...
January 2018: Journal of Neurosciences in Rural Practice
https://www.readbyqxmd.com/read/29453470/nerve-conduction-and-heart-rate-variability-in-patients-with-hypothyroidism-at-a-tertiary-care-centre-in-eastern-nepal
#4
Shital Gupta, Rita Khadka, Dilip Thakur, Robin Maskey, K D Mehta, B H H Paudel
INTRODUCTION: Thyroid hormone effects on many organs including central and peripheral nervous systems. However, these hormones do not affect all systems/organs to a similar extent. Thus, we conducted this study to explore the effect of thyroid hormones on somatic nervous system assessed by Nerve conduction study and cardiac autonomic activity assessed by heart rate variability. METHODS: The study included newly diagnosed hypothyroid patients and healthy controls...
October 2017: JNMA; Journal of the Nepal Medical Association
https://www.readbyqxmd.com/read/29453349/ultrasound-and-shock-wave-stimulation-to-promote-axonal-regeneration-following-nerve-surgery-a-systematic-review-and-meta-analysis-of-preclinical-studies
#5
Simeon C Daeschler, Leila Harhaus, Philipp Schoenle, Arne Boecker, Ulrich Kneser, Konstantin D Bergmeister
Limited regeneration after nerve injury often leads to delayed or incomplete reinnervation and consequently insufficient muscle function. Following nerve surgery, application of low-intensity ultrasound or extracorporeal shock waves may promote nerve regeneration and improve functional outcomes. Because currently clinical data is unavailable, we performed a meta-analysis following the PRISMA-guidelines to investigate the therapeutic effect of ultrasound and shock wave therapies on motor nerve regeneration. Ten ultrasound-studies (N = 445 rats) and three shock-wave studies (N = 110 rats) were identified from multiple databases...
February 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29447059/therapeutic-potential-of-mucuna-pruriens-linn-on-ageing-induced-damage-in-dorsal-nerve-of-the-penis-and-its-implication-on-erectile-function-an-experimental-study-using-albino-rats
#6
Prakash Seppan, Ibrahim Muhammed, Karthik Ganesh Mohanraj, Ganesh Lakshmanan, Dinesh Premavathy, Sakthi Jothi Muthu, Khayinmi Wungmarong Shimray, Sathya Bharathy Sathyanathan
OBJECTIVE: To study the effect of ethanolic seed extract of Mucuna pruriens on damaged dorsal nerve of the penis (DNP) in aged rat in relation to penile erection. METHODS: The rats were divided into four groups Young (3 months), Aged (24 - 28 months), Aged + M. pruriens, and Young + M. pruriens (200 mg/kg b.w/60 days) and were subjected to the hypophysial - gonadal axis, nerve conduction velocity (NCV), and penile reflex. DNP sections were stained with nitric oxide synthase (nNOS), nicotinamide adenine dinucleotide phosphate (NaDPH) diaphorase, androgen receptor (AR), and osmium tetroxide...
February 15, 2018: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
https://www.readbyqxmd.com/read/29443415/comprehensive-assessment-of-the-donor-site-of-the-anterolateral-thigh-flap-a-prospective-study-in-33-patients
#7
Shuang Bai, Zhi-Qiang Zhang, Zhi-Qiang Wang, Zhong-Fei Xu, Wei-Yi Duan, Fa-Yu Liu, Xue-Xin Tan, Chang-Fu Sun
BACKGROUND: The anterolateral thigh (ALT) free flap has been an extremely versatile flap. The purpose of this study was to propose comprehensive functional assessments of the donor site. METHODS: A total of 33 ALT flaps were enrolled prospectively. Objective assessments included isokinetic testing of the knee, and electromyographic examination of the lateral femoral cutaneous nerve (LFCN). The Patient and Observer Scar Assessment Scale (POSAS) was used to subjectively assess the donor-site scar...
February 14, 2018: Head & Neck
https://www.readbyqxmd.com/read/29436863/proinsulin-expressing-dendritic-cells-in-type-2-neuropathic-diabetic-patients-with-and-without-foot-lesions
#8
Maria Sambataro, Luisa Sambado, Enrica Trevisiol, Matilde Cacciatore, Anna Furlan, Piero Maria Stefani, Elena Seganfreddo, Elisabetta Durante, Stefania Conte, Silvia Della Bella, Agostino Paccagnella, Angelo Paolo Dei Tos
Diabetic neuropathy is the most common complication of diabetes and is frequently associated with foot ischemia and infection, but its pathogenesis is controversial. We hypothesized that proinsulin expression in peripheral blood mononuclear cells is a process relevant to this condition and could represent a link among hyperglycemia, nerve susceptibility, and diabetic foot lesions. We assessed proinsulin expression by using flow cytometry in dendritic cells from control participants and patients with type 2 diabetic with or without peripheral neuropathy or accompanied by diabetic foot...
February 12, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29436383/effect-of-long-term-electroacupuncture-stimulation-on-recovery-of-sensorimotor-function-after-peripheral-nerve-anastomosis
#9
Mingxing Zhang, Ye Zhang, Yuhong Bian, Hui Fu, Ying Xu, Yi Guo
BACKGROUND: Recently, application of electroacupuncture (EA) to stimulate nerve regeneration has become a mainstream treatment in clinical rehabilitation and related basic research, but the efficacy of long-term stimulation has not been confirmed. OBJECTIVE: To evaluate the influence of long term EA on peripheral nerve injury (PNI) from multiple angles. METHOD: Twenty-four rats were divided into three groups: control, PNI and PNI+EA. In the latter two groups, PNI was modelled by transection followed by re-anastomosis of thesciatic nerve...
February 7, 2018: Acupuncture in Medicine: Journal of the British Medical Acupuncture Society
https://www.readbyqxmd.com/read/29430866/difference-in-normal-limit-values-of-nerve-conduction-parameters-between-westerner-and-japanese-people-may-need-to-be-considered-when-diagnosing-diabetic-polyneuropathy-using-a-point-of-care-sural-nerve-conduction-device-nc-stat%C3%A2-dpncheck%C3%A2
#10
Kazuhiro Hirayasu, Hideyuki Sasaki, Shohei Kishimoto, Seigo Kurisu, Koji Noda, Kenichi Ogawa, Hiroto Tanaka, Yumiko Sakakibara, Shohei Matsuno, Hiroto Furuta, Mikio Arita, Keigo Naka, Kishio Nanjo
AIM/INTRODUCTION: Studies on a novel point-of-care device for nerve conduction study called DPNCheck have been limited to Westerners. We aimed to clarify Japanese normal limits of nerve action potential (Amp) and conduction velocity (CV) by DPNCheck (Investigation-I), and validity of DPNCheck to identify diabetic symmetric sensorimotor polyneuropathy (DSPN) (Investigation-II). MATERIALS AND METHODS: Investigation-I: 463 non-neuropathic Japanese subjects underwent DPNCheck examinations...
February 11, 2018: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/29429781/high-prevalence-and-incidence-of-diabetic-peripheral-neuropathy-in-children-and-adolescents-with-type-1-diabetes-mellitus-results-from-a-five-year-prospective-cohort-study
#11
Isabella Walter-Höliner, Daniela Seick Barbarini, Jürg Lütschg, Anya Blassnig-Ezeh, Ulrike Zanier, Christoph H Saely, Burkhard Simma
BACKGROUND: In this prospective cohort study, we investigated the prevalence of diabetic peripheral neuropathy at baseline and after five years of follow-up in children and adolescents with type 1 diabetes mellitus using both measurements of nerve conduction velocity and clinical neurological examination. METHODS: A total of 38 patients who underwent insulin pump or intensive insulin therapy were included. The subjects averaged 12.6 ± 2.4 years of age and their diabetes duration averaged 5...
December 13, 2017: Pediatric Neurology
https://www.readbyqxmd.com/read/29424937/pathogenesis-of-cranial-neuropathies-in-moebius-syndrome-electrodiagnostic-orofacial-studies
#12
Francis Renault, Roberto Flores-Guevara, Bernard Sergent, Jean Jacques Baudon, Jessie Aouizerate, Marie-Paule Vazquez, Cyril Gitiaux
INTRODUCTION: We designed a retrospective study of 59 patients with congenital sporadic non-progressive bilateral facial and abducens palsies. METHODS: Examinations included needle EMG of facial and oral muscles, facial nerve motor latency and conduction velocity (FNCV), and blink responses (BRs). RESULTS: Neurogenic EMG changes were found in one or more muscles in 55/59 patients, with no abnormal spontaneous activity. EMG changes were homogeneously neurogenic in 17 patients, homogeneously myopathic in one, and heterogeneous in 41/59 patients...
February 9, 2018: Muscle & Nerve
https://www.readbyqxmd.com/read/29424054/chitin-biological-absorbable-catheters-bridging-sural-nerve-grafts-transplanted-into-sciatic-nerve-defects-promote-nerve-regeneration
#13
Zhi-Yong Wang, Jian-Wei Wang, Li-Hua Qin, Wei-Guang Zhang, Pei-Xun Zhang, Bao-Guo Jiang
AIMS: To investigate the efficacy of chitin biological absorbable catheters in a rat model of autologous nerve transplantation. METHODS: A segment of sciatic nerve was removed to produce a sciatic nerve defect, and the sural nerve was cut from the ipsilateral leg and used as a graft to bridge the defect, with or without use of a chitin biological absorbable catheter surrounding the graft. The number and morphology of regenerating myelinated fibers, nerve conduction velocity, nerve function index, triceps surae muscle morphology, and sensory function were evaluated at 9 and 12 months after surgery...
February 8, 2018: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29419686/the-clinical-efficacy-of-epalrestat-combined-with-%C3%AE-lipoic-acid-in-diabetic-peripheral-neuropathy-protocol-for-a-systematic-review-and-meta-analysis
#14
Xiaotong Wang, Haixiong Lin, Shuai Xu, Yuanlin Jin, Ren Zhang
BACKGROUND: Diabetic peripheral neuropathy (DPN) is a common long-term complication of diabetes mellitus, affecting patients in the world. Epalrestat combined with α-lipoic acid (ALA) is the most frequent combine therapy used in the DPN researches. We aim to assess the effectiveness and safety of epalrestat combined with ALA in patients with DPN, compare with epalrestat alone. METHODS: We will search Cochrane Library, PubMed, Wanfang Data, China National Knowledge Infrastructure, VIP Chinese Science and Technology Journals Database, and Chinese Biomedical Database from inception until October 31th, 2017...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29416195/assessment-of-pharmacological-responses-to-an-anti-diabetic-drug-in-a-new-obese-type-2-diabetic-rat-model
#15
Yasutaka Murai, Takeshi Ohta, Hironobu Tadaki, Katsuhiro Miyajima, Masami Shinohara, Fatchiyah Fatchiyah, Takahisa Yamada
Introduction: The number of diabetic patients has recently been increasing worldwide, and numerous anti-diabetic drugs have been developed to induce good glycemic control. In particular, metformin, which exhibits glucose-lowering effects by suppressing gluconeogenesis in the liver, is widely used as a first line oral anti-diabetic drug for type 2 diabetes mellitus. Material and Methods: In this study, the pharmacological effects of metformin were investigated using female and male Spontaneously Diabetic Torii (SDT) fatty rats, a new obese type 2 diabetic model...
December 2017: Medical Archives
https://www.readbyqxmd.com/read/29412513/determination-of-peripheral-neuropathy-in-high-fat-fed-low-dose-streptozotocin-treated-female-c57bl-6j-mice-and-sprague-dawley-rats
#16
Lawrence J Coppey, Hanna Shevalye, Alexander Obrosov, Eric P Davidson
AIMS/INTRODUCTION: Peripheral neuropathy is a common complication of diabetes and also occurs in 30% of human obese subjects with impaired glucose tolerance. Even though peripheral neuropathy affects both genders most pre-clinical studies have been performed using male rodents. The aim of this study was to create diet induced obesity and type 2 diabetes in female rats and mice in order to examine development of peripheral neuropathy. MATERIALS AND METHODS: At twelve weeks of age rats and mice were separated into three groups...
February 7, 2018: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/29406919/correlation-between-serum-uric-acid-and-diabetic-peripheral-neuropathy-in-t2dm-patients
#17
Xiaopu Lin, Lingling Xu, Deqiang Zhao, Zhiyin Luo, Suyue Pan
AIM: To investigate the correlation between serum uric acid (SUA) and diabetic peripheral neuropathy (DPN) in type 2 diabetes mellitus (T2DM) patients. METHODS: Two hundred T2DM patients were divided into four groups at the cut-off points of 5, 7, and 9mg/dL of SUA levels. Nerve conduction studies (NCS), Semmes-Weinstein monofilament testing (SWMT), and vibration perception threshold (VPT) tests were performed on these patients. RESULTS: Significant differences in motor/sensory nerve amplitude and conduction velocity (CV) parameters among different SUA level groups were observed (all P<0...
February 15, 2018: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29406910/immunohistochemistry-and-electrophysiological-findings-in-swine-abattoir-workers-with-immune-mediated-polyradiculoneuropathy
#18
Suraj A Muley, Stacy Holzbauer, Brent Clark, James Sejvar, Ruth Lynfield, Gareth Parry, Aaron S DeVries
IMPORTANCE: Workers exposed to aerosolized brain in a swine-processing plant developed immune-mediated polyradiculoneuropathy (IP) possibly triggered by an immune response. OBJECTIVE: Immunohistochemistry results were correlated with electrophysiological variables to examine the immunopathogenesis of this disorder. DESIGN/SETTING: Laboratory studies used normal nerve tissue that was exposed to sera from 12 IP patients; 10 exposed controls; and 10 unexposed controls...
February 15, 2018: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29402528/influence-of-chronic-volume-overload-induced-atrial-remodeling-on-electrophysiological-responses-to-cholinergic-receptor-stimulation-in-the-isolated-rat-atria
#19
Xin Cao, Megumi Aimoto, Marie Fukumoto, Yoshinobu Nagasawa, Hikaru Tanaka, Akira Takahara
Whereas molecular mechanisms of atrial fibrillation (AF) have been widely investigated, there is limited information regarding interrelation between chronic volume overload and parasympathetic nervous system in the pathophysiology of AF. In this study, we investigated the influence of abdominal aorto-venocaval shunt (AVS)-induced atrial remodeling on electrophysiological responses to cholinergic receptor stimulation in the isolated rat atria. Interstitial fibrosis, cardiomyocyte hypertrophy and atrial enlargement, known as structural arrhythmogenic substrates for AF, took place after one month of AVS operation...
January 16, 2018: Journal of Pharmacological Sciences
https://www.readbyqxmd.com/read/29400678/a-comparative-study-of-rehabilitation-therapy-in-traumatic-upper-limb-peripheral-nerve-injuries
#20
Cristian Milicin, Elena Sîrbu
INTRODUCTION: Lower motor neurons are the only neurons of the central nervous system (CNS) with the ability to regenerate without any intervention after an axotomy. AIM: This present study was conducted to analyze clinical and electrophysiological parameters in four groups of upper limb peripheral neuropathies, before and after treatment, comparing the results obtained after three cures of complex rehabilitation therapy. MATERIALS AND METHODS: We selected a number of 107 patients (66 women and 41 men) aged between 29 and 77 years (mean age = 49...
2018: NeuroRehabilitation
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