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https://www.readbyqxmd.com/read/27915068/effects-of-the-pulsed-ultrasound-therapy-on-sensory-nerve-conduction-parameters-and-the-pain-threshold-perceptions-in-humans
#1
Othmar Schuhfried, Damir Vukanovic, Christian Kollmann, Karin Pieber, Tatjana Paternostro-Sluga
BACKGROUND: Therapeutic ultrasound is a often used clinical modality in the non-surgical treatment of entrapment neuropathies. To date the possible mechanism of action of pulsed ultrasound therapy on the peripheral nerve in the treatment of entrapment neuropathies is unclear. OBJECTIVE: To examine the effects of pulsed ultrasound therapy on peripheral nerve conduction parameters. DESIGN: A prospective, randomized, single blind, cross-over study...
November 30, 2016: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/27910920/the-dose-dependent-efficiency-of-radial-shock-wave-therapy-for-patients-with-carpal-tunnel-syndrome-a-prospective-randomized-single-blind-placebo-controlled-trial
#2
Ming-Jen Ke, Liang-Cheng Chen, Yu-Ching Chou, Tsung-Ying Li, Heng-Yi Chu, Chia-Kuang Tsai, Yung-Tsan Wu
Recently, extracorporeal shock wave therapy (ESWT) has been shown to be a novel therapy for carpal tunnel syndrome (CTS). However, previous studies did not examine the diverse effects of different-session ESWT for different-grades CTS. Thus, we conducted a randomized, single-blind, placebo-controlled study. Sixty-nine patients (90 wrists) with mild to moderate CTS were randomized into 3 groups. Group A and C patients received one session of radial ESWT (rESWT) and sham eESWT per week for 3 consecutive weeks, respectively; Group B patients received a single session of rESWT...
December 2, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27904499/boric-acid-reduces-axonal-and-myelin-damage-in-experimental-sciatic-nerve-injury
#3
Zahir Kızılay, Haydar Ali Erken, Nesibe Kahraman Çetin, Serdar Aktaş, Burçin İrem Abas, Ali Yılmaz
The aim of this study was to investigate the effects of boric acid in experimental acute sciatic nerve injury. Twenty-eight adult male rats were randomly divided into four equal groups (n = 7): control (C), boric acid (BA), sciatic nerve injury (I), and sciatic nerve injury + boric acid treatment (BAI). Sciatic nerve injury was generated using a Yasargil aneurysm clip in the groups I and BAI. Boric acid was given four times at 100 mg/kg to rats in the groups BA and BAI after injury (by gavage at 0, 24, 48 and 72 hours) but no injury was made in the group BA...
October 2016: Neural Regeneration Research
https://www.readbyqxmd.com/read/27895925/somatic-neural-alterations-in-non-diabetic-obesity-a-cross-sectional-study
#4
Ram Lochan Yadav, Deepak Sharma, Prakash Kumar Yadav, Dev Kumar Shah, Kopila Agrawal, Rita Khadka, Md Nazrul Islam
BACKGROUND: Reports on alterations in somatic neural functions due to non-diabetic obesity, a major risk factor for diabetes, are few and still a matter of debate. Nevertheless, to our knowledge, reports lack any comments on the type of somatic nerve fibers affected in non-diabetic obesity. Therefore, this study aimed to find out the alteration in somatic neural functions in non-diabetic obese persons if any. METHODS: The study was conducted on 30 adult non-diabetic obese persons (mean age 32...
2016: BMC Obesity
https://www.readbyqxmd.com/read/27895823/effect-of-pioglitazone-on-nerve-conduction-velocity-of-the-median-nerve-in-the-carpal-tunnel-in-type-2-diabetes-patients
#5
Sudip Chatterjee, Debmalya Sanyal, Sourav Das Choudhury, Mili Bandyopadhyay, Suraj Chakraborty, Arabinda Mukherjee
AIM: To evaluate the impact of pioglitazone pharmacotherapy in median nerve electrophysiology in the carpal tunnel among type 2 diabetes patients. METHODS: The study was executed in patients with type 2 diabetes, treated with oral drugs, categorized under pioglitazone or non-pioglitazone group (14 in each group), and who received electrophysiological evaluation by nerve conduction velocity at baseline and 3 mo. RESULTS: At 3 mo, pioglitazone-category had inferior amplitude in sensory median nerve [8...
November 15, 2016: World Journal of Diabetes
https://www.readbyqxmd.com/read/27894152/surgical-decompression-in-the-treatment-of-diabetic-peripheral-neuropathy-a-systematic-review-and-meta-analysis
#6
Yiji Tu, William Charles Lineaweaver, Zenggan Chen, Junda Hu, Fred Mullins, Feng Zhang
Background Over the last decade, surgical decompression procedures have been commonly used in the treatment of diabetic peripheral neuropathy. However, the effectiveness of them remains to be proved. Methods A comprehensive literature search of databases including PubMed-Medline, Ovid-EMBASE, and Cochrane Library was performed to collect the related literatures. The Medical Subject Headings used were "diabetic neuropathy," "surgical decompression," and "outcomes." The methodological index for nonrandomized studies was adopted for assessing the studies included in this review...
November 28, 2016: Journal of Reconstructive Microsurgery
https://www.readbyqxmd.com/read/27893494/a-comparison-of-magnetic-resonance-imaging-and-electroneuromyography-for-denervated-muscle-diagnosis
#7
Betül Tepeli, Metin Karataş, Mehmet Coşkun, Oya Ümit Yemişçi
INTRODUCTION: The aim of this study was to evaluate the diagnostic value of magnetic resonance imaging (MRI) for muscle denervation due to focal lesions of the median nerve and to compare electrophysiological findings with MRI findings. METHODS: Twenty-six patients with electrophysiological studies diagnose for focal lesions of the median nerve were included in this study. Electrophysiological studies and MRI were conducted on 34 patients' hands. Patient hands were divided into two groups based on edema findings revealed by the MRI: group 1 (edema-negative group; n = 24) and group 2 (edema-positive group; n = 10)...
November 21, 2016: Journal of Clinical Neurophysiology: Official Publication of the American Electroencephalographic Society
https://www.readbyqxmd.com/read/27882734/novel-mutations-in-sh3tc2-in-a-young-japanese-girl-with-charcot-marie-tooth-disease-type-4c
#8
Kazushi Ichikawa, Keita Numasawa, Saoko Takeshita, Akihiro Hashiguchi, Hiroshi Takashima
Charcot-Marie-Tooth disease type 4C (CMT4C) is an autosomal recessive demyelinating form of CMT characterized clinically by early onset and severe spinal deformities, and is caused by mutations in SH3TC2. We describe the case of a 10-year-old Japanese girl diagnosed with CMT4C. The patient developed progressive foot deformities such as marked pes cavus and ankle contracture, with mild muscle weakness in both legs, and generalized areflexia. On electrophysiological studies, motor nerve conduction velocity ranged from 22...
November 2016: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/27861125/4-aminopyridine-promotes-functional-recovery-and-remyelination-in-acute-peripheral-nerve-injury
#9
Kuang-Ching Tseng, Haiyan Li, Andrew Clark, Leigh Sundem, Michael Zuscik, Mark Noble, John Elfar
Traumatic peripheral nerve damage is a major medical problem without effective treatment options. In repurposing studies on 4-aminopyridine (4-AP), a potassium channel blocker that provides symptomatic relief in some chronic neurological afflictions, we discovered this agent offers significant promise as a small molecule regenerative agent for acute traumatic nerve injury. We found, in a mouse model of sciatic crush injury, that sustained early 4-AP administration increased the speed and extent of behavioral recovery too rapidly to be explained by axonal regeneration...
December 1, 2016: EMBO Molecular Medicine
https://www.readbyqxmd.com/read/27856098/gastric-perforation-and-critical-illness-polyneuropathy-after-steroid-treatment-in-a-patient-with-encephalitis-encephalopathy-with-transient-splenial-lesion
#10
Mitsuru Ikeno, Shinpei Abe, Hirokazu Kurahashi, Michihiko Takasu, Toshiaki Shimizu, Akihisa Okumura
The outcome of mild encephalitis/encephalopathy with reversible splenial lesion (MERS) is favorable whether or not specific treatment is performed. We report a patient with MERS treated with methylprednisolone, complicated by gastric perforation followed by critical illness polyneuropathy. The patient was a 14-year-old male with mildly impaired consciousness and hyponatremia who was treated with methylprednisolone pulse therapy. High fever appeared after methylprednisolone pulse therapy and free air was recognized on an abdomen roentgenogram...
November 14, 2016: Brain & Development
https://www.readbyqxmd.com/read/27829055/a-novel-approach-for-studying-the-physiology-and-pathophysiology-of-myelinated-and-non-myelinated-axons-in-the-cns-white-matter
#11
Lijun Li, Alexander A Velumian, Marina Samoilova, Michael G Fehlings
Advances in brain connectomics set the need for detailed knowledge of functional properties of myelinated and non-myelinated (if present) axons in specific white matter pathways. The corpus callosum (CC), a major white matter structure interconnecting brain hemispheres, is extensively used for studying CNS axonal function. Unlike another widely used CNS white matter preparation, the optic nerve where all axons are myelinated, the CC contains also a large population of non-myelinated axons, making it particularly useful for studying both types of axons...
2016: PloS One
https://www.readbyqxmd.com/read/27825059/islet-cell-transplantation-improves-nerve-conduction-velocity-in-type-1-diabetes-compared-with-intensive-medical-therapy-over-six-years
#12
Blake Fensom, Claire Harris, Sharon E Thompson, Mohammed Al Mehthel, David M Thompson
BACKGROUND: Neuropathy is a common diabetic complication that can result in significant disability. Few treatment options exist to reverse this process. METHODS: We conducted a one-way crossover cohort study comparing intensive medical treatment and islet cell transplantation for type 1 diabetes on the change in nerve conduction velocity over six years. FINDINGS: For subjects with some neuropathy at baseline (Z score below -1), nerve conduction velocity significantly improved post-transplant (slope (0...
October 19, 2016: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/27822509/peripheral-neuropathy-in-patients-with-cpeo-associated-with-single-and-multiple-mtdna-deletions
#13
Diana Lehmann, Malte E Kornhuber, Carolina Clajus, Charlotte L Alston, Andreas Wienke, Marcus Deschauer, Robert W Taylor, Stephan Zierz
OBJECTIVE: To characterize peripheral nerve involvement in patients with chronic progressive external ophthalmoplegia (CPEO) with single and multiple mitochondrial DNA (mtDNA) deletions, based on clinical scores and detailed nerve conduction studies. METHODS: Peripheral nerve involvement was prospectively investigated in 33 participants with CPEO (single deletions n = 18 and multiple deletions n = 15). Clinically, a modified Total Neuropathy Score (mTNS) and a modified International Cooperative Ataxia Rating Scale (mICARS) were used...
December 2016: Neurology. Genetics
https://www.readbyqxmd.com/read/27818568/redox-status-of-%C3%AE-2gpi-in-different-stages-of-diabetic-angiopathy
#14
Jun Ma, Jing-Yun Zhang, Yan Liu, De-Min Yu, Pei Yu
We explored the redox status of beta 2 glycoprotein I (β2GPI) in different stages of diabetic angiopathy. Type 2 diabetes mellitus (T2DM) had a significantly lower proportion of reduced β2GPI as compared to healthy controls (p < 0.05). There was a trend that the mild coronal atherosclerosis heart disease (CAD) had higher proportion of reduced β2GPI than non-CAD and severe-CAD groups, however without significances (p > 0.05). The mild-A-stenosis group and mild-diabetic retinopathy (DR) groups had higher proportion of reduced β2GPI than their severely affected counterparts...
2016: Disease Markers
https://www.readbyqxmd.com/read/27799904/are-there-abnormalities-in-peripheral-and-central-components-of-somatosensory-evoked-potentials-in-non-specific-chronic-low-back-pain
#15
Christian Puta, Marcel Franz, Kathrin R Blume, Holger H W Gabriel, Wolfgang H R Miltner, Thomas Weiss
Chronic low back pain (CLBP) was shown to be associated with longer reflex response latencies of trunk muscles during external upper limb perturbations. One theoretical, but rarely investigated possibility for longer reflex latencies might be related to modulated somatosensory information processing. Therefore, the present study investigated somatosensory evoked potentials (SEPs) to median nerve stimulation in CLBP patients and healthy controls (HC). Latencies of the peripheral N9 SEP component were used as the primary outcome...
2016: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/27795728/radix-astragali-based-chinese-herbal-medicine-for-oxaliplatin-induced-peripheral-neuropathy-a-systematic-review-and-meta-analysis
#16
REVIEW
Bo Deng, Liqun Jia, Zhiqiang Cheng
Background. Treatment of chemotherapy-induced peripheral neuropathy (CIPN) remains a big challenge for oncologists. The aim of this study is to evaluate the effects of Radix Astragali- (RA-) based Chinese herbal medicine in the prevention and treatment of oxaliplatin-induced peripheral neuropathy, including the incidence and grading of neurotoxicity, effective percentage, and nerve conduction velocity. Methods. All randomized controlled trials (RCTs) were found using PubMed, Cochrane, Springer, China National Knowledge Infrastructure (CNKI), and Wanfang Database of China Science Periodical Database (CSPD) by keyword search...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/27792993/abnormal-autonomic-nervous-system-function-in-rural-thai-men-a-potential-contributor-to-their-high-risk-of-sudden-unexplained-nocturnal-death-syndrome
#17
Raoyrin Chanavirut, Terdthai Tong-Un, Dusit Jirakulsomchok, J Michael Wyss, Sanya Roysommuti
BACKGROUND: Rural compared to urban Thai populations have a higher incidence of sudden unexplained nocturnal death syndrome (SUNDS). This study tests the hypothesis that compared to young urban Thai men, the young rural northeast Thai men display autonomic system dysfunction that may contribute to their relatively high risk to develop SUNDS. METHODS: Forty-seven healthy second and third year students from Khon Kaen University (20-22years old) were divided into central, urban northeastern, and rural northeastern groups, based on the locality in which they had grown up and in which their parents had lived prior to their birth...
October 4, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27790497/an-unusual-presentation-of-scrub-typhus
#18
Giridhar Reddy Banda, Srikrishna Raghavendra Boddu, Priyanka Ballal, Jayaprakash Belle
Presentation of scrub typhus associated with brachial neuritis is extremely rare with only a few cases reported so far. Here, we report a case of a 45-year-old female who presented with fever and right shoulder pain. Laboratory parameters showed leucocytosis with ELISA and PCR for scrub typhus positive. Electromyography (EMG) and Nerve Conduction Velocity (NCV) study was suggestive of brachial neuritis. She was given doxycycline therapy for 10 days following which her shoulder pain resolved.
September 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27789344/behavioral-and-electromyographic-assessment-of-oxaliplatin-induced-motor-dysfunctions-evidence-for-a-therapeutic-effect-of-allopregnanolone
#19
Omar Taleb, Fateh Bouzobra, Hava Tekin-Pala, Laurence Meyer, Ayikoé, G Mensah-Nyagan, Christine Patte-Mensah
The antineoplastic oxaliplatin (OXAL) is pivotal for metastatic cancer treatments. However, OXAL evokes sensory and motor side-effects including pain, muscle weakness, motor nerve fiber dysfunctions/neuropathies that significantly impact patients' lives. Therefore, preclinical investigations are struggling to characterize effective analgesics against OXAL-induced painful/sensory symptoms but surprisingly, OXAL-evoked motor dysfunctions received little attention although these neurological symptoms are also disabling for patients...
October 24, 2016: Behavioural Brain Research
https://www.readbyqxmd.com/read/27785412/neuroradiological-neurophysiological-and-molecular-findings-in-infantile-krabbe-disease-two-case-reports
#20
E Vargiami, E Papathanasiou, S Batzios, M Kyriazi, E Dimitriou, A Anastasiou, H Michelakakis, A-K Giese, D I Zafeiriou
Krabbe disease is an autosomal recessive neurodegenerative disorder due to a defect of the lysosomal enzyme β-galactocerebrosidase (β-GALC). Depending on the age of onset, the disease is classified into infantile and later-onset forms. We report neuroradiological, neurophysiological and molecular findings in two Greek patients with the infantile form of Krabbe disease. The index patients presented at the age of 3.5 and 6 months, respectively, due to developmental delay. Magnetic resonance imaging (MRI) of the first patient's brain demonstrated signs of leukodystrophy, while nerve conduction velocities (NCVs) were significantly decreased...
July 1, 2016: Balkan Journal of Medical Genetics: BJMG
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