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https://www.readbyqxmd.com/read/29678392/skeletal-status-in-women-with-carpal-tunnel-syndrome-a-1-yr-prospective-study
#1
Aleksander Kisała, Wojciech Pluskiewicz, Piotr Adamczyk
Functional deterioration due to carpal tunnel syndrome (CTS) may influence the bone status of the forearm and hand. The aim of this prospective study was to establish whether CTS has an impact on bone status at distal parts of the upper limb and to monitor the longitudinal changes of that status during a 1-yr follow-up after surgical treatment. Fifteen women with CTS at mean age of 55.13 ± 9.3 yr, mean weight of 79.18 ± 20.37 kg, and mean height of 157.8 ± 6.17 cm were enrolled into the study...
March 27, 2018: Journal of Clinical Densitometry
https://www.readbyqxmd.com/read/29676840/behavioral-morphological-and-electrophysiological-assessment-of-the-effects-of-type-2-diabetes-mellitus-on-large-and-small-nerve-fibers-in-zucker-diabetic-fatty-rat-zucker-lean-and-wistar-rats
#2
E Garcia-Perez, T Schönberger, M Sumalla, B Stierstorfer, R Solà, H Doods, J Serra, N Gorodetskaya
BACKGROUND: Peripheral neuropathy is a common complication in type 2 diabetes mellitus (T2DM). The most common presentation is in the form of a distal axonal sensory-motor polyneuropathy that involves large and small nerve fibers in variable proportion. METHODS: Zucker Diabetic Fatty rats (ZDF), Zucker Lean (ZL) and Wistar Han (WH) rats were used to asses the behavioral, morphological and electrophysiological effects that T2DM have on peripheral large and small nerve fibers of 6-40 week-old rats...
April 20, 2018: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/29675271/the-relationship-between-peripheral-nerve-conduction-velocity-and-ophthalmological-findings-in-type-2-diabetes-patients-with-early-diabetic-retinopathy
#3
Azusa Ito, Hiroshi Kunikata, Masayuki Yasuda, Shojiro Sawada, Keiichi Kondo, Chihiro Satake, Kazuki Hashimoto, Naoko Aizawa, Hideki Katagiri, Toru Nakazawa
Purpose: Nerve conduction velocity (NCV) is an indicator of neuronal damage in the distal segment of the peripheral nerves. Here, we determined the association between NCV and other systemic and ocular clinical findings, in type 2 diabetes patients with early diabetic retinopathy (DR). Methods: This study included 42 eyes of 42 type 2 diabetes patients (median age: 54 years) with no DR or with mild nonproliferative DR. Standard statistical techniques were used to determine associations between clinical findings...
2018: Journal of Ophthalmology
https://www.readbyqxmd.com/read/29674850/effect-of-dietary-oils-on-peripheral-neuropathy-related-endpoints-in-dietary-obese-rats
#4
Lawrence Coppey, Eric Davidson, Hanna Shevalye, Michael E Torres, Mark A Yorek
Purpose: This study aimed to determine the effect of dietary oils (olive, safflower, evening primrose, flaxseed, or menhaden) enriched in different mono unsaturated fatty acids or polyunsaturated fatty acids on peripheral neuropathies in diet-induced obese Sprague-Dawley rats. Materials and methods: Rats at 12 weeks of age were fed a high-fat diet (45% kcal) for 16 weeks. Afterward, the rats were fed diets with 50% of the kilocalories of fat derived from lard replaced by the different dietary oils...
2018: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
https://www.readbyqxmd.com/read/29661920/dhtkd1-deficiency-causes-charcot-marie-tooth-disease-in-mice
#5
Wang-Yang Xu, Houbao Zhu, Yan Shen, Ying-Han Wan, Xiao-Die Tu, Wen-Ting Wu, Lingyun Tang, Hong-Xin Zhang, Shun-Yuan Lu, Xiao-Long Jin, Jian Fei, Zhu-Gang Wang
DHTKD1, a part of 2-ketoadipic acid dehydrogenase complex, is involved in lysine and tryptophan catabolism. Mutations in DHTKD1 block the metabolic pathway and cause 2-aminoadipic and 2-oxoadipic aciduria (AMOXAD), an autosomal recessive inborn metabolic disorder. In addition, a nonsense mutation in DHTKD1 we identified previously causes Charcot-Marie-Tooth disease (CMT) type 2Q, one of the most common inherited neurological disorders affecting the peripheral nerves in the musculature. However, the comprehensive molecular mechanism underlying CMT2Q remains elusive...
April 16, 2018: Molecular and Cellular Biology
https://www.readbyqxmd.com/read/29657932/normative-ulnar-nerve-conduction-study-comparison-of-two-measurement-methods
#6
Shila Haghighat, Amir Ebrahim Mahmoodian, Lida Kianimehr
Background: Given the high prevalence rate of ulnar neuropathy and importance of its proper management, to have a baseline information about the normative value of motor nerve conduction of first dorsal interosseous (FDI) muscle and abductor digiti minimi muscle (ADM) and their differences as well as their relation with different demographic characteristics of our population, we aimed to determine and compare the mean value of motor conduction velocity of FDI and ADM at forearm and across the elbow among the normal population...
2018: Advanced Biomedical Research
https://www.readbyqxmd.com/read/29649487/expression-patterns-and-role-of-pten-in-rat-peripheral-nerve-development-and-injury
#7
Hui Chen, Jianping Xiang, Junxia Wu, Bo He, Tao Lin, Qingtang Zhu, Xiaolin Liu, Canbin Zheng
Studies have suggested that phosphatase and tensin homolog (PTEN) plays an important role in neuroprotection and neuronal regeneration. To better understand the potential role of PTEN with respect to peripheral nerve development and injury, we investigated the expression pattern of PTEN at different stages of rat peripheral nerve development and injury and subsequently assessed the effect of pharmacological inhibition of PTEN using bpV(pic) on axonal regeneration in a rat sciatic nerve crush injury model. During the early stages of development, PTEN exhibits low expression in neuronal cell bodies and axons...
April 9, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29649429/deletion-of-the-insulin-receptor-in-sensory-neurons-increases-pancreatic-insulin-levels
#8
Caleb W Grote, Natalie M Wilson, Natalie K Katz, Brianne L Guilford, Janelle M Ryals, Lesya Novikova, Lisa Stehno-Bittel, Douglas E Wright
Insulin is known to have neurotrophic properties and loss of insulin support to sensory neurons may contribute to peripheral diabetic neuropathy (PDN). Here, genetically-modified mice were generated in which peripheral sensory neurons lacked the insulin receptor (SNIRKO mice) to determine whether disrupted sensory neuron insulin signaling plays a crucial role in the development of PDN and whether SNIRKO mice develop symptoms of PDN due to reduced insulin neurotrophic support. Our results revealed that SNIRKO mice were euglycemic and never displayed significant changes in a wide range of sensorimotor behaviors, nerve conduction velocity or intraepidermal nerve fiber density...
April 9, 2018: Experimental Neurology
https://www.readbyqxmd.com/read/29644933/grip-strength-of-occupational-workers-in-relation-with-carpal-tunnel-syndrome-and-individual-factors
#9
Greesh Kumar Singh, Sanjay Srivastava
The main objective of the present work was to determine the association of grip strength with carpal tunnel syndrome (CTS) for occupational workers exposed to the risk of CTS. Experiments were performed on sixty workers, fifteen from each occupation. Grip strength was measured using hand dynamometer. Electrophysiological experiments were conducted to measure CTS. Three levels of CTS were identified on the basis of latency value and motor nerve conduction velocity, viz., mild, moderate, and severe. Statistical results suggest that workers having CTS lose their grip strength, and higher levels of CTS lead to greater reduction in the grip strength...
April 12, 2018: International Journal of Occupational Safety and Ergonomics: JOSE
https://www.readbyqxmd.com/read/29644112/unusual-bilateral-sensory-innervation-of-the-dorsum-of-hand-by-lateral-antebrachial-cutaneous-nerve-a-case-report
#10
Neha, Hare Krishna
A 68-year-old male cadaver showed bilateral variation in the sensory innervation of the dorsum of hand. On the dorsum of right hand, first digit and lateral half of second digit were supplied by lateral antebrachial cutaneous nerve (LABCN); medial side of second digit and lateral side of third digit were supplied by superficial branch of radial nerve (SBRN) and medial side of third digit, the fourth and fifth digits were supplied by dorsal cutaneous branch of ulnar nerve (DBUN). On the dorsum of the left hand, lateral side of first digit was supplied by LABCN, medial side of first digit, the second and third digits as well as the lateral side of fourth digit were supplied by SBRN; medial side of fourth digit and fifth digit were supplied by DBUN...
March 2018: Anatomy & Cell Biology
https://www.readbyqxmd.com/read/29629543/partial-conduction-block-as-an-early-nerve-conduction-finding-in-neurolymphomatosis
#11
Hyung Jun Park, Ha Young Shin, Se Hoon Kim, Ha Neul Jeong, Young Chul Choi, Bum Chun Suh, Kee Duk Park, Seung Min Kim
BACKGROUND AND PURPOSE: Neurolymphomatosis is a rare manifestation of hematological malignancy and is characterized by direct infiltration of the peripheral nervous system. The objective of this study was to identify the clinical and electrophysiological features of neurolymphomatosis. METHODS: We retrospectively analyzed the medical records of 13 patients with neurolymphomatosis. Seven (54%) of the patients were men, and the median age at symptom onset was 60.0 years...
January 2018: Journal of Clinical Neurology
https://www.readbyqxmd.com/read/29626178/unique-clinical-and-neurophysiologic-profile-of-a-cohort-of-children-with-cmtx3
#12
Manoj Kanhangad, Kayla Cornett, Megan H Brewer, Garth A Nicholson, Monique M Ryan, Robert L Smith, Gopinath M Subramanian, Helen K Young, Stephan Züchner, Marina L Kennerson, Joshua Burns, Manoj P Menezes
OBJECTIVE: To describe in detail the clinical profile of Charcot-Marie-Tooth disease subtype 3 (CMTX3) to aid appropriate genetic testing and rehabilitative therapy. METHODS: We reviewed the clinical and neurophysiologic profile and CMT Pediatric Scale (CMTPedS) assessments of 11 children with CMTX3. RESULTS: Compared with the more common forms of CMT, CMT1A and CMTX, CMTX3 was characterized by early onset with early and progressive hand weakness...
April 6, 2018: Neurology
https://www.readbyqxmd.com/read/29625948/comparing-the-diagnostic-accuracy-of-simple-tests-to-screen-for-diabetic-peripheral-neuropathy-protocol-for-a-cross-sectional-study
#13
Kate Goddard, Prashanth Vas, Alistair Purves, Viktoria McMillan, Thomas Langford, Fiona Reid, Michael Edmonds
BACKGROUND: Various tests are used to detect diabetic peripheral neuropathy by assessing sense perception in the feet. Tests vary in terms of time and resources required. Simple tests are those that can be conducted quickly and easily in primary care without laboratory equipment. There are some limitations to these simple tests, an example being the variable amplitude of the 128 Hz tuning fork. A new test, VibraTip (McCallan Medical, UK), might be a valuable alternative as it emits a consistent amplitude and may offer improved diagnostic accuracy...
April 6, 2018: JMIR Research Protocols
https://www.readbyqxmd.com/read/29623933/electroacupuncture-and-moxibustion-promote-regeneration-of-injured-sciatic-nerve-through-schwann-cell-proliferation-and-nerve-growth-factor-secretion
#14
Lin-Na Hu, Jin-Xin Tian, Wei Gao, Jing Zhu, Fang-Fang Mou, Xiao-Chun Ye, Yu-Pu Liu, Ping-Ping Lu, Shui-Jin Shao, Hai-Dong Guo
Using electroacupuncture and moxibustion to treat peripheral nerve injury is highly efficient with low side effects. However, the electroacupuncture- and moxibustion-based mechanisms underlying nerve repair are still unclear. Here, in vivo and in vitro experiments uncovered one mechanism through which electroacupuncture and moxibustion affect regeneration after peripheral nerve injury. We first established rat models of sciatic nerve injury using neurotomy. Rats were treated with electroacupuncture or moxibustion at acupoints Huantiao (GB30) and Zusanli (ST36)...
March 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/29623298/a-murine-model-of-charcot-marie-tooth-disease-4f-reveals-a-role-for-the-c-terminus-of-periaxin-in-the-formation-and-stabilization-of-cajal-bands
#15
Diane L Sherman, Peter J Brophy
Charcot-Marie-Tooth (CMT) disease comprises up to 80 monogenic inherited neuropathies of the peripheral nervous system (PNS) that collectively result in demyelination and axon degeneration. The majority of CMT disease is primarily either dysmyelinating or demyelinating in which mutations affect the ability of Schwann cells to either assemble or stabilize peripheral nerve myelin. CMT4F is a recessive demyelinating form of the disease caused by mutations in the Periaxin ( PRX ) gene . Periaxin (Prx) interacts with Dystrophin Related Protein 2 (Drp2) in an adhesion complex with the laminin receptor Dystroglycan (Dag)...
2018: Wellcome Open Research
https://www.readbyqxmd.com/read/29619066/efficacy-and-safety-of-the-injection-of-the-traditional-chinese-medicine-puerarin-for-the-treatment-of-diabetic-peripheral-neuropathy-a-systematic-review-and-meta-analysis-of-53-randomized-controlled-trials
#16
REVIEW
Baocheng Xie, Qinghui Wang, Chenhui Zhou, Jiahuan Wu, Daohua Xu
Objective: The injection of the traditional Chinese patent medicine puerarin has been widely used in the treatment of various diseases such as angina pectoris or ischemic stroke. We aim to evaluate the efficacy and safety of puerarin injection for the treatment of diabetic peripheral neuropathy (DPN). Methods: A systematic literature search was performed in seven medical databases from their inception until June 2017. 53 studies with RCTs, totaling 3284 patients, were included in this meta-analysis...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29615088/ultrasound-guided-needle-release-of-the-transverse-carpal-ligament-with-and-without-corticosteroid-injection-for-the-treatment-of-carpal-tunnel-syndrome
#17
Xuan-Yan Guo, Mao-Xiang Xiong, Man Lu, Xue-Qing Cheng, Yan-Yan Wu, Shi-Yin Chen, Kai Chen, Qiao-Dan Zhou, Lei Wang, Li Tan, Jie-Rong Quan, Fan-Ding He, Qin Chen
BACKGROUND: To compare the clinical effectiveness of ultrasound-guided needle release of the transverse carpal ligament (TCL) with and without corticosteroid injection in carpal tunnel syndrome (CTS). METHODS: From June 2016 to June 2017, 49 CTS patients (50 wrists) were included in this study. Twenty-five wrists were treated with ultrasound-guided needle release of the TCL plus corticosteroid injection (group A), and 25 wrists were treated with single ultrasound-guided needle release of the TCL (group B)...
April 3, 2018: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/29614623/ring-finger-sensorial-conduction-studies-in-grading-carpal-tunnel-syndrome-part-ii
#18
Murat Alemdar
BACKGROUND: Comparison of sensory conduction of median nerve (MN) with the one of ulnar nerve (UN) over writs-to-ring finger (RF) segment is useful in electrodiagnosis of carpal tunnel syndrome (CTS). However, there is not any consensus regarding the usage of this technique in grading of CTS. OBJECTIVES: To determine whether the hands of CTS with elicitable MN sensory responses on index finger, but not on RF (non-respondings) compose a more severe electrophysiologic grade than the hands with elicitable responses on both fingers (respondings)...
March 23, 2018: Journal of Back and Musculoskeletal Rehabilitation
https://www.readbyqxmd.com/read/29608799/one-stop-microvascular-screening-service-an-effective-model-for-the-early-detection-of-diabetic-peripheral-neuropathy-and-the-high-risk-foot
#19
O Binns-Hall, D Selvarajah, D Sanger, J Walker, A Scott, S Tesfaye
AIMS: To evaluate the feasibility of a one-stop microvascular screening service for the early diagnosis of diabetic distal symmetrical polyneuropathy, painful distal symmetrical polyneuropathy and the at-risk diabetic foot. METHODS: People with diabetes attending retinal screening in hospital and community settings had their feet examined by a podiatrist. Assessment included: Toronto Clinical Neuropathy Score evaluation; a 10-g monofilament test; and two validated, objective and quick measures of neuropathy obtained using the point-of-care devices 'DPN-Check', a hand-held device that measures sural nerve conduction velocity and amplitude, and 'Sudoscan', a device that measures sudomotor function...
April 2, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/29606547/effect-of-aerobic-training-on-nerve-conduction-in-men-with-type-2-diabetes-and-peripheral-neuropathy-a-randomized-controlled-trial
#20
Farhad Gholami, Saeed Nikookheslat, Yaghoub Salekzamani, Normand Boule, Afshar Jafari
OBJECTIVE: Peripheral neuropathy (PN) is one of the long-term complications of diabetes. Few studies have investigated the role of regular exercise on diabetic PN. We examined the effect of aerobic training on nerve conduction velocity and action potential amplitude in the lower limbs of men with type 2 diabetes and PN. METHODS: In a randomized controlled study, 24 volunteers diagnosed with diabetic PN were randomly assigned to exercise or control groups. Aerobic training consisted of 20-45min walking or running at 50-70% of heart rate reserve for three sessions per week over 12weeks...
March 29, 2018: Neurophysiologie Clinique, Clinical Neurophysiology
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