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anaerobic system and diabetes mellitus

Lyvia Biagi, Arthur Bertachi, Carmen Quirós, Marga Giménez, Ignacio Conget, Jorge Bondia, Josep Vehí
Continuous glucose monitoring (CGM) plays an important role in treatment decisions for patients with type 1 diabetes under conventional or closed-loop therapy. Physical activity represents a great challenge for diabetes management as well as for CGM systems. In this work, the accuracy of CGM in the context of exercise is addressed. Six adults performed aerobic and anaerobic exercise sessions and used two Medtronic Paradigm Enlite-2 sensors under closed-loop therapy. CGM readings were compared with plasma glucose during different periods: one hour before exercise, during exercise, and four hours after the end of exercise...
March 9, 2018: Biosensors
M Juncar, S Bran, R I Juncar, M F Baciut, G Baciut, F Onisor-Gligor
INTRODUCTION: Cervical necrotizing fasciitis is a rare but very severe infection that affects the soft-tissues of the cephalic extremity. Cervical necrotizing fasciitis most frequently occurs secondarily to inflammatory odontogenic disorders and represents the most severe infection of maxillofacial spaces, with a high lethal potential. MATERIALS AND METHODS: In this study, we selected 55 patients with confirmed cervical necrotizing fasciitis of odontogenic origin, treated in the Clinic of Oral and Maxillofacial Surgery in Cluj-Napoca during January 1996-December 2012...
May 2016: Nigerian Journal of Clinical Practice
Cord Sunderkötter, Karsten Becker
Skin and soft tissue infections rank among the most frequent infections worldwide. Classic erysipelas is defined as a non-purulent infection by beta-hemolytic streptococci. The typical signs are tender, warm, bright erythema with tongue-like extensions and early systemic symptoms such as fever or at least chills. Erysipelas always and best responds to penicillin. Limited soft tissue infection or limited cellulitis are the terms we have introduced for infections frequently caused by S. aureus and often originating from chronic wounds or acute trauma...
June 2015: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
Hiroshi Hidaka, Takuhiro Yamaguchi, Jun Hasegawa, Hisakazu Yano, Risako Kakuta, Daiki Ozawa, Kazuhiro Nomura, Yukio Katori
BACKGROUND: Diabetes mellitus has been recognized as the most common systemic disease associated with deep neck infection. We report the first systematic review and meta-analysis of the influence of diabetes on clinical and bacteriological characteristics of deep neck infection. METHODS: Articles were retrieved from PubMed, EMBASE, and the Japan Medical Abstracts Society database. A critical review of 227 studies identified 20 studies eligible for quantitative synthesis...
October 2015: Head & Neck
S A Aliev, É S Aliev, B M Zeĭnalov
The results of treatment of scrotum gangrene (Fournier's disease) in 25 patients aged from 34 to 82 years are presented in the article. The diseases of colorectal zone were nosological reasons of Fournier's disease in 13 patients, the diseases of urogenital tract - in 10 cases. Development of Fournier's disease was associated with closed trauma in 1 patient, and 1 case was associated with gunshot wound of perineum and scrotum. Slowly progressing forms of the disease were detected in 14 patients, fulminant and rapidly progressing variants - in 11 patients...
2014: Khirurgiia
Munvar M Shaik, Sultan Ahmad, Siew H Gan, Adel M Abuzenadah, Ejaz Ahmad, Shams Tabrez, Farid Ahmed, Mohammad A Kamal
Chronic infection can cause slow progressive dementia, cortical atrophy and amyloid deposition in the atrophic form of general paresis. Due to the fact that specific bacterial ligands can increase the expression of proinflammatory molecules that can activate innate and adaptive immune systems, inflammation may play a significant role in the pathogenesis of Alzheimer's disease (AD). Furthermore, there is a significant association between AD and various types of spirochete. Periodontitis is a prevalent and persistent peripheral infection that is associated with gram-negative anaerobic bacteria and is capable of showing localized and systemic infections in the host...
April 2014: CNS & Neurological Disorders Drug Targets
J Wakim El Khoury, D Décosterd
Type 2 diabetes, a world-wide epidemic, is a major concern of health systems around the world. The recommandation of its early management with metformin by the majority of guidelines has made metformin the object of multiple studies to demonstrate its benefits, but more importantly its side effects among whom the most serious is lactic acidosis. The latter is rare, but responsible for high mortality rates and is strongly associated with acute and chronic conditions for which diabetics are prone. These conditions reduce tissue perfusion and activate anaerobic metabolism producing lactate...
August 14, 2013: Revue Médicale Suisse
M Bomba, D Ciavardelli, E Silvestri, L M T Canzoniero, R Lattanzio, P Chiappini, M Piantelli, C Di Ilio, A Consoli, S L Sensi
Recent studies have shown that type 2 diabetes mellitus (T2DM) is a risk factor for cognitive dysfunction or dementia. Insulin resistance is often associated with T2DM and can induce defective insulin signaling in the central nervous system as well as increase the risk of cognitive impairment in the elderly. Glucagone like peptide-1 (GLP-1) is an incretin hormone and, like GLP-1 analogs, stimulates insulin secretion and has been employed in the treatment of T2DM. GLP-1 and GLP-1 analogs also enhance synaptic plasticity and counteract cognitive deficits in mouse models of neuronal dysfunction and/or degeneration...
2013: Cell Death & Disease
S M F Lima, D C Grisi, E M Kogawa, O L Franco, V C Peixoto, J F Gonçalves-Júnior, M P Arruda, T M B Rezende
Diabetes mellitus (DM) is one of the most common metabolic disorders. DM is characterized by hyperglycaemia, resulting in wound healing difficulties and systemic and oral manifestations, which have a direct effect on dental pulp integrity. Experimental and clinical studies have demonstrated a higher prevalence of periapical lesions in patients with uncontrolled diabetes. The influence of DM on periapical bone resorption and its impact on dental intervention of such patients are reviewed, and its aetiology and pathogenesis are analysed at molecular level...
August 2013: International Endodontic Journal
Kyung Mook Choi, Kyung Ah Han, Hee Jung Ahn, Soon Young Hwang, Ho Cheol Hong, Hae Yoon Choi, Sae Jeong Yang, Hye Jin Yoo, Sei Hyun Baik, Dong Seop Choi, Kyung Wan Min
CONTEXT: Low levels of soluble receptor for advanced glycation end-products (sRAGE) have been linked to systemic inflammation and vascular complications in patients with type 2 diabetes mellitus (T2DM). OBJECTIVE: We examined the effects of exercise on sRAGE and its association with diverse cardiometabolic risk factors and indicators of atherosclerosis in patients with T2DM. DESIGN, SETTING, AND PARTICIPANTS: Seventy-five patients with T2DM were randomized into a control group and an aerobic exercise group (60 min at moderate intensity, five times/wk for 12 wk)...
October 2012: Journal of Clinical Endocrinology and Metabolism
J-J Segura-Egea, L Castellanos-Cosano, G Machuca, J López-López, J Martín-González, E Velasco-Ortega, B Sánchez-Domínguez, F-J López-Frías
The possible connection between chronic oral inflammatory processes, such as apical periodontitis and periodontal disease (PD), and systemic health is one of the most interesting aspects faced by the medical and dental scientific community. Chronic apical periodontitis shares important characteristics with PD: 1) both are chronic infections of the oral cavity, 2) the Gram-negative anaerobic microbiota found in both diseases is comparable, and 3) in both infectious processes increased local levels of inflammatory mediators may have an impact on systemic levels...
March 2012: Medicina Oral, Patología Oral y Cirugía Bucal
Georgios I Kourtoglou
Medical nutrition therapy and physical exercise are the cornerstones of the diabetes management. Patients with type 1 DM always need exogenous insulin administration, recently available in the form of insulin analogs. In type 2 DM, characterized by increased insulin resistance and progressive decline of the beta-cell function, various antidiabetic medications are used. Most of the subjects with type 2 DM will finally need insulin. The main site of insulin action is the skeletal muscle, while the liver is the main site of glucose storage in the form of glycogen...
August 2011: Diabetes Research and Clinical Practice
Hyeung-June Kim, Dong-Heon Kim, Duk-Hwan Ko
Necrotizing fasciitis (NF) is a deep infection of the subcutaneous tissue that progressively destroys fascia and fat; it is associated with systemic toxicity, a fulminant course, and high mortality. NF most frequently develops from trauma that compromises skin integrity, and is more common in patients with predisposing medical conditions such as diabetes mellitus, atherosclerosis, alcoholism, renal disease, liver disease, immunosuppression, malignancy, or corticosteroid use. Most often, NF is caused by polymicrobial pathogens including aerobic and anaerobic bacteria...
December 2010: Clinics in Orthopedic Surgery
M Pedalino, O G Di Primio, R Vella, E Vercesi, G Marino
Fournier's disease is a necrotizing fasciitis that prefers the male and which is located in the perineal area. In view of possible complications related to sepsis, systemic organ impairment and high mortality, is now considered a urological emergency. The main causes are infections of urethral and anorectal tract, immunodepression syndromes, diabetes mellitus and trauma. Infections are mixed with aerobic and anaerobic germs responsible of necrosis of tissue disorders due to the phenomena of necrotizing immunovasculitis disease...
January 2010: Urologia
L Ozsari, N Karadurmus, M Sahin, G Uckaya, A U Ural, M Kutlu
Diabetes mellitus (DM) is a complex disease that affects many systems. The most important cells of the immune system are lymphomononuclear (LMN) cells. Here, we aimed to evaluate the energy metabolism of LMN cells in patients with diabetes and impaired glucose tolerance. We measured LMN cell energy metabolism in patients with type 2 diabetes mellitus, impaired glucose tolerance (IGT) and healthy subjects. Cells were freshly isolated from peripheral blood and the subgroups were determined by flow cytometric method...
February 2010: Endocrine
Kay Ohlendieck
Glycolysis represents one of the best-understood and most ancient metabolic pathways. In skeletal muscle fibres, energy for contraction is supplied by adenosine triphosphate via anaerobic glycolysis, the phosphocreatine shuttle and oxidative phosphorylation. In this respect, the anaerobic glycolytic pathway supports short duration performances of contractile tissues of high intensity. The catalytic elements associated with glycolysis are altered during development, muscle differentiation, physiological adaptations and many pathological mechanisms, such as muscular dystrophy, diabetes mellitus and age-related muscle weakness...
November 2010: Biochimica et Biophysica Acta
Jaime S Rosa, Rebecca L Flores, Stacy R Oliver, Andria M Pontello, Frank P Zaldivar, Pietro R Galassetti
Poor glycemic control in Type 1 diabetes (T1DM) causes long-term cardiovascular complications, at least in part via chronic, low-grade inflammation associated with recurrent hyperglycemia. While physical activity can reduce both inflammation and cardiovascular risks, the underlying molecular mechanisms remain unclear. This is particularly important for T1DM children, for whom the prevention of long-term cardiovascular complications must include optimization of exercise-related anti-inflammatory strategies. We therefore studied the effect of prior hyperglycemia on resting and exercise-induced inflammatory status (plasma IL-6) in T1DM children...
February 2010: Journal of Applied Physiology
Toshihiko Nagata
Periodontal disease is a chronic inflammatory disorder by the anaerobic bacteria invasion into periodontal tissues including gingival connective tissue, periodontal ligament, and alveolar bone. Periodontitis is classified into two types, gingivitis and periodontitis. Diabetic patients tend to suffer from periodontitis with severe alveolar bone loss caused by lowered immune reaction and delayed tissue recovering. Periodontal pathogens such as P. gingivalis lipopolysaccharide (P-LPS) and several cytokines (TNF-alpha, IL-1 and IL-6) stimulate osteoclast differentiation in gingival connective tissue...
September 2009: Clinical Calcium
S A Aliev, S F Rafiev, F S Rafiev, E S Aliev
Results of treatment of fulminating scrotum gangrene (Fournier disease) in 17 patients at the age of 34-82 years are presented. Bounded (slow progressive) forms were observed in 12 patients, widespread (fulminant and rapidly progressive) forms--in 5 patients. Colorectal pathology as the most likely cause of Fournier disease was observed in 8 patients, urogenital pathology--in 7 patients. In 2 patients blunt injury (1) and gunshot wound (1) of scrotum preceded the development of Fournier disease. 5 patients suffered from diabetes mellitus differed in severity...
2008: Khirurgiia
Hideto Suzuki, Kazumoto Murata, Atsushi Sakamoto
A 67-year-old female with uncontrolled diabetes mellitus (DM) was admitted to a hospital because of sudden onset of mid-abdominal pain. Laboratory data only showed mild elevation of white blood cell counts. She was diagnosed as constipation, and given laxative and enema. However, 9 h after the admission, her blood pressure suddenly went down with developing of metabolic acidosis, and died 20 h after the admission. Forensic autopsy revealed massive pneumohemia in the venous system. Edematous dark-brown colored lesions of mucosal surface were discontinuously observed from terminal ileum to sigmoid colon with bloody ascites...
April 2009: Legal Medicine
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