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MiRNA T lymphocyte

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https://www.readbyqxmd.com/read/29752469/microrna-17-92-cluster-promotes-the-proliferation-and-the-chemokine-production-of-keratinocytes-implication-for-the-pathogenesis-of-psoriasis
#1
Weigang Zhang, Xiuli Yi, Yawen An, Sen Guo, Shuli Li, Pu Song, Yuqian Chang, Shaolong Zhang, Tianwen Gao, Gang Wang, Chunying Li
Keratinocytes are the main epidermal cell type that constitutes the skin barrier against environmental damages, which emphasizes the balance between the growth and the death of keratinocytes in maintaining skin homeostasis. Aberrant proliferation of keratinocytes and the secretion of inflammatory factors from keratinocytes are related to the formation of chronic inflammatory skin diseases like psoriasis. MicroRNA-17-92 (miRNA-17-92 or miR-17-92) is a miRNA cluster that regulates cell growth and immunity, but the role of miR-17-92 cluster in keratinocytes and its relation to skin diseases have not been well investigated...
May 11, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29743596/genome-wide-profiling-of-micrornas-reveals-novel-insights-into-the-interactions-between-h9n2-avian-influenza-virus-and-avian-dendritic-cells
#2
Jian Lin, Jing Xia, Tian Zhang, Keyun Zhang, Qian Yang
The antigen-presenting ability of dendritic cells (DCs) plays an important and irreplaceable role in recognising and clearing viruses. Antiviral responses must rapidly defend against infection while minimising inflammatory damage, but the mechanisms that regulate the magnitude of response within an infected cell are not well understood. MicroRNAs (microRNAs), small non-coding RNAs, can regulate mouse or avian DCs to inhibit the infection and replication of avian influenza virus (AIV). Here, we performed a global analysis to understand how avian DCs respond to H9N2 AIV and provide a potential mechanism to explain how avian microRNAs can defend against H9N2 AIV replication...
May 10, 2018: Oncogene
https://www.readbyqxmd.com/read/29737865/next-generation-sequencing-for-mirna-profile-of-spleen-cd4-t-cells-in-the-murine-model-of-acute-asthma
#3
Ye Liu, Zhongqi Chen, Kun Xu, Zhengxia Wang, Chaojie Wu, Zhixiao Sun, Ningfei Ji, Mao Huang, Mingshun Zhang
AIM: To explore the miRNAs profile of CD4+ T lymphocytes in asthma via next generation sequencing. METHODS: In the murine model of acute asthma, spleen CD4+ T lymphocytes were sorted, in which small RNAs were extracted and sequenced. Novel miRNAs were measured with real time quantitative reverse transcription polymerase chain reaction (qRT-PCR). RESULTS: A total of 127 miRNAs were found to exhibit at least twofold change. In the 262 predicted novel miRNAs, 14 novel miRNAs were measured in qRT-PCR in the sorted CD4+ T cells or in the differentiated Th1/Th2 cells and novel miR-11 (xxx-m0228-3p) was significantly decreased in the sorted CD4+ T cells from the murine model of asthma and in the Th2 cells...
May 8, 2018: Epigenomics
https://www.readbyqxmd.com/read/29684716/predicted-mirna-mrna-mediated-posttranscriptional-control-associated-with-differences-in-cervical-and-thoracic-thymus-function
#4
Amanda F Assis, Jie Li, Paula B Donate, Janaína A Dernowsek, Nancy R Manley, Geraldo A Passos
A secondary cervical thymus (CT) is present in the neck region in about 50% of human and mice. CT in mice is an independent and functional organ, which can be colonized by T lymphocyte progenitors and generate thymocytes that are selected by the T cell receptor repertoire following the positive and negative selection. However, CT and the main thoracic thymus (TT) have been shown in mice to have significant functional differences. In this study, we use transcriptional profiling to compare mRNA or miRNAs expression patterns in murine CT and TT...
April 20, 2018: Molecular Immunology
https://www.readbyqxmd.com/read/29578533/microrna-663-induces-immune-dysregulation-by-inhibiting-tgf-%C3%AE-1-production-in-bone-marrow-derived-mesenchymal-stem-cells-in-patients-with-systemic-lupus-erythematosus
#5
Linyu Geng, Xiaojun Tang, Kangxing Zhou, Dandan Wang, Shiying Wang, Genhong Yao, Weiwei Chen, Xiang Gao, Wanjun Chen, Songtao Shi, Nan Shen, Xuebing Feng, Lingyun Sun
Mesenchymal stem cells (MSCs) are critical for immune regulation. Although several microRNAs (miRNAs) have been shown to participate in autoimmune pathogenesis by affecting lymphocyte development and function, the roles of miRNAs in MSC dysfunction in autoimmune diseases remain unclear. Here, we show that patients with systemic lupus erythematosus (SLE) display a unique miRNA signature in bone marrow-derived MSCs (BMSCs) compared with normal controls, among which miR-663 is closely associated with SLE disease activity...
March 26, 2018: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/29570251/tumor-derived-exosomes-modulate-t-cell-function-through-transfer-of-rna
#6
Imran G House, Emma V Petley, Paul A Beavis
Tumor cells can develop a variety of mechanisms to evade and subvert the immune system for their survival. Bland et al., in this edition of The FEBS Journal, make the novel finding that the tumor line B16F0 can deliver mRNA/miRNA loaded exosomes to cytotoxic T lymphocytes and alter their metabolic function and interferon gamma production.
March 2018: FEBS Journal
https://www.readbyqxmd.com/read/29551498/analysis-of-the-expression-of-mir-34a-mir-199a-mir-30c-and-mir-19a-in-peripheral-blood-cd4-t-lymphocytes-of-relapsing-remitting-multiple-sclerosis-patients
#7
Nooshin Ghadiri, Negaralsadat Emamnia, Mazdak Ganjalikhani-Hakemi, Kamran Ghaedi, Masoud Etemadifar, Mansoor Salehi, Hedayatollah Shirzad, Mohammad Hossein Nasr-Esfahani
BACKGROUND: Multiple sclerosis is an immune-mediated inflammatory disease of central nervous system. MicroRNAs play important roles in autoimmune diseases such as MS. OBJECTIVES: The aim was to evaluate the expression pattern of miR-34a, miR-199a, miR-30c and miR-19a in peripheral blood derived CD4+ T lymphocytes of both relapsing and remitting phases of MS. METHODS: Blood samples from 40 RRMS patients (20 in relapsing and 20 in remitting phase) and 20 healthy volunteers were taken...
June 15, 2018: Gene
https://www.readbyqxmd.com/read/29471302/socs3-is-upregulated-and-targeted-by-mir30a-5p-in-allergic-rhinitis
#8
Chun Yuan Zhao, Wei Wang, Hong Chao Yao, Xin Wang
BACKGROUND: Suppressor of cytokine signaling 1 (SOCS1) and SOCS3 play important roles in T helper cell differentiation, which is involved with the pathologic mechanisms of allergic rhinitis (AR). The aim of this study was to evaluate the expression of SOCS1 and SOCS3 in AR and find their regulatory microRNAs (miRNAs) to provide a basis for the treatment of AR. METHODS: The expression of SOCS1 and SOCS3 were analyzed by real-time PCR, immunohistochemistry, and Western blot...
2018: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/29459719/mir-142-3p-regulates-autophagy-by-targeting-atg16l1-in-thymic-derived-regulatory-t-cell-ttreg
#9
Yunjie Lu, Ji Gao, Shaopeng Zhang, Jian Gu, Hao Lu, Yongxiang Xia, Qin Zhu, Xiaofeng Qian, Feng Zhang, Chuanyong Zhang, Hongbing Shen, Keli L Hippen, Bruce R Blazar, Ling Lu, Xuehao Wang
Thymic-derived regulatory T cell (tTreg) clinical trials show therapeutic promise in the prevention of acute graft-versus-host disease (GVHD) in allogeneic hematopoietic stem cell transplantation patients. However, strategies are needed to improve tTreg proliferative ability and survival as a means to improve tTreg therapy and reduce the requirement for producing large numbers of Treg cells for adoptive tTreg transfer. Autophagy is a self-degradative process for cytosolic components, which is involved in cells death, differentiation, lymphocyte homeostasis, and tTreg function...
February 19, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29423087/design-of-mirna-sponges-for-mdv-1-as-a-therapeutic-strategy-against-lymphomas
#10
Yuan Fang, Yuqi Zhou, Yun Zhang, Liangliang He, Chunyi Xue, Yongchang Cao
Lymphomas are solid-type tumors containing lymphoid cells. Some of latent herpesvirus infections established in B and/or T-lymphocytes could result in the formation of lymphomas. Marek's disease virus serotype 1 (MDV-1) is an avian herpes virus causing to lymphoproliferative tumors in birds, known as Marek's disease (MD). MD has often been used as an ideal biological model for studying the pathogenesis of lymphoma diseases caused by viruses. Therefore, we used it as a research subject to study the effect of miRNA sponges on its tumorigenicity, and to develop the theoretical basis for a new anti-tumor small molecule...
January 9, 2018: Oncotarget
https://www.readbyqxmd.com/read/29347945/microrna-transcriptome-analysis-of-porcine-vital-organ-responses-to-immunosuppressive-porcine-cytomegalovirus-infection
#11
Xiao Liu, Haoche Wei, Shan Liao, Jianheng Ye, Ling Zhu, Zhiwen Xu
BACKGROUND: Porcine cytomegalovirus (PCMV) is an immunosuppressive virus that mainly inhibits T-lymphocyte and macrophage immune functions; it has significantly damaged the farming industry. Although recent studies have shown that miRNAs play important roles in immune responses, the regulatory mechanisms of miRNAs during immunosuppressive virus infection remain unclear. METHODS: In this study, porcine small-RNA transcriptomes of PCMV-infected and uninfected vital organs were first characterised by high-throughput sequencing...
January 18, 2018: Virology Journal
https://www.readbyqxmd.com/read/29282311/a-cellular-microrna-facilitates-regulatory-t-lymphocyte-development-by-targeting-the-foxp3-promoter-tata-box-motif
#12
Yiwen Zhang, Weiwei Liu, Yingshi Chen, Jun Liu, Kang Wu, Lishi Su, Wanying Zhang, Yawen Jiang, Xu Zhang, Yijun Zhang, Chao Liu, Liang Tao, Bingfeng Liu, Hui Zhang
The CD4+ CD25+ FOXP3+ regulatory T cells (Tregs) mediate immunological self-tolerance and suppress various immune responses. FOXP3 is a key transcriptional factor for the generation and development of Tregs. Its expression is regulated by various cytokines including TGF-β, IL-2, and IL-10. It is important to further identify the regulatory factors for Tregs. Given that many microRNAs (miRNAs) could specifically interact with the core promoter region and specifically enhance the transcription of many target genes, we searched for any possible miRNA(s) targeting the core promoter region of the FOXP3 gene...
February 1, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29176936/role-of-microrna-33a-in-regulating-the-expression-of-pd-1-in-lung-adenocarcinoma
#13
Laura Boldrini, Mirella Giordano, Cristina Niccoli, Franca Melfi, Marco Lucchi, Alfredo Mussi, Gabriella Fontanini
Background: MiRNAs are vital in functioning as either oncogenes or tumor suppressors in the cell cycle. Target transcripts for immune checkpoint molecules such as PD-1/PD-L1 and (programmed cell death-1/its ligand and cytotoxic T-lymphocyte antigen 4) have proven to be beneficial against several solid tumors, including lung adenocarcinoma. Methods: Simultaneous quantification of the expression level of miR-33a and PD - 1 , PD - L1 and CTLA4 mRNAs with NanoString technology was performed in 88 lung adenocarcinoma specimens...
2017: Cancer Cell International
https://www.readbyqxmd.com/read/29170128/cerebrospinal-fluid-cd4-t-lymphocyte-derived-mirna-let-7b-can-enhances-the-diagnostic-performance-of-alzheimer-s-disease-biomarkers
#14
Yaping Liu, Xiaojing He, Yanling Li, Tian Wang
Alzheimer's disease is very difficult to clinically diagnose. miRNAs constitute the promising next generation of Alzheimer's disease (AD) biomarkers and have the potential to diagnose neurodegenerative diseases. In this study, 94 subjects underwent extensive dementia screening. Let-7b miRNA was found to increase in association with the progression of AD, and the increase in let-7b miRNA was mainly due to CD4+ T cells in the cerebrospinal fluid (CSF). Additionally, let-7b was positively correlated with the expression of t-Tau and p-Tau...
January 1, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29163428/hhv-6a-6b-infection-of-nk-cells-modulates-the-expression-of-mirnas-and-transcription-factors-potentially-associated-to-impaired-nk-activity
#15
Roberta Rizzo, Irene Soffritti, Maria D'Accolti, Daria Bortolotti, Dario Di Luca, Elisabetta Caselli
Natural killer (NK) cells have a critical role in controlling virus infections, and viruses have evolved several mechanisms to escape NK cell functions. In particular, Human herpesvirus 6 (HHV-6) is associated with diseases characterized by immune dysregulation and has been reported to infect NK cells. We recently found that HHV-6 in vitro infection of human thyroid follicular epithelial cells and T-lymphocytes modulates several miRNAs associated with alterations in immune response. Since miRNAs are key regulators of many immune pathways, including NK cell functions, we aimed to study the impact of HHV-6A and -6B in vitro infection on the intracellular mediators correlated to NK cell function...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29158064/mir-223-is-repressed-and-correlates-with-inferior-clinical-features-in-mantle-cell-lymphoma-through-targeting-sox11
#16
REVIEW
Keshu Zhou, Xiaoyan Feng, Yanying Wang, Yanyan Liu, Long Tian, Wenli Zuo, Shuhua Yi, Xudong Wei, Yongping Song, Lugui Qiu
Mantle cell lymphoma (MCL) is an aggressive lymphoid malignancy characterized by cytogenetic aberration of t(11;14), although it is not the prerequisite. Until now, the pathogenesis of MCL has not been fully interpreted. Our current study showed that microRNA (miR)-223 was downregulated in purified CD19+ lymphocytes from MCL patients (n = 21) compared with that of healthy donors (n = 20). In addition, patients with a high-risk Mantle Cell Lymphoma International Prognostic Index (MIPI) score, elevated lactate dehydrogenase, and Eastern Cooperative Oncology Group performance status >2 were more likely to have much lower miR-223 expression...
February 2018: Experimental Hematology
https://www.readbyqxmd.com/read/29156819/mir-29a-3p-suppresses-cell-proliferation-and-migration-by-downregulating-igf1r-in-hepatocellular-carcinoma
#17
Xiao Wang, Shasha Liu, Ling Cao, Tengfei Zhang, Dongli Yue, Liping Wang, Yu Ping, Qianyi He, Chaoqi Zhang, Meng Wang, Xinfeng Chen, Qun Gao, Dan Wang, Zhen Zhang, Fei Wang, Li Yang, Jieyao Li, Lan Huang, Bin Zhang, Yi Zhang
Hepatocellular carcinoma (HCC), the most common primary tumor of the liver, has a poor prognosis and rapid progression. MicroRNAs (miRNAs) play important roles in carcinogenesis and tumor progression. Insulin-like growth factor 1 receptor (IGF1R) is a transmembrane heterotetrameric protein that has been reported to promote transformation to malignancy and cancer cell proliferation and survival. In this study, we found that the expression of miR-29a-3p was downregulated in HCC patients, resulting in poor survival rates...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29138813/reduced-mirna%C3%A2-214-expression-in-oral-mucosa-contributes-to-the-pathogenesis-of-oral-lichen-planus-by-targeting-cd44
#18
Haiyan Zheng, Shaohui Li
The present study aimed to investigate the role of miRNAs during the pathogenesis of oral lichen planus (OLP). OLP is a chronic inflammatory disorder, which involves T‑cell mediated autoimmunity and affects the skin, scalp, nails and mucosa. Abundant T lymphocytes have been demonstrated to infiltrate the oral mucosa, in which the activated T cells trigger apoptosis of oral epithelial cells. Overexpression of osteopontin (OPN) and CD44 has been observed in the mucosa of patients with OLP, and it has been confirmed that OPN suppresses the apoptosis of activated CD8+ T cells via CD44...
January 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29107863/elevated-expression-of-mir-146-mir-139-and-mir-340-involved-in-regulating-th1-th2-balance-with-acute-exposure-of-fine-particulate-matter-in-mice
#19
Tianfang Hou, Jiping Liao, Cheng Zhang, Chao Sun, Xueying Li, Guangfa Wang
Airborne fine particulate matter (PM2.5) is detrimental to human health, and frequently leads to a variety of lung diseases. Recently, IARC conclude that particulate matter is carcinogenic to humans (level one). However, the pulmonary toxicological mechanism induced by PM2.5 remains obscure. Our previous studies confirmed that PM2.5 hurt the human immune system by means of causing the imbalance of Th1/Th2 lymphocytes. MicroRNAs (miRNAs) are post-transcriptional gene suppressors and potential mediators of environmental effects, which play an important role in the regulation of CD4+ T lymphocyte differentiation...
January 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/28990564/-mirnas-new-actors-in-the-physiopathology-of-multiple-sclerosis
#20
Ferdinand Jagot, Nathalie Davoust
Multiple sclerosis (MS) is an auto-immune demyelinating disorder characterized by a chronic neuro-inflammatory process associated with an infiltration of the central nervous system (CNS) by autoreactive lymphocytes. The etiology of the disease remains unclear but the recent discovery of a dysregulated miRNA network in both cells and extracellular fluids of MS patients has brought new insights on the pathophysiological mechanisms involved in this disorder. miRNAs can induce a T cell polarization towards a pathological Th17 or Th1 phenotype and a deleterious activation of microglia, the CNS-resident macrophages...
June 2017: Médecine Sciences: M/S
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