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https://www.readbyqxmd.com/read/29037257/ventriculoperitoneal-shunt-insertion-for-hydrocephalus-in-human-immunodeficiency-virus-infected-adults-a-systematic-review-and-meta-analysis-protocol
#1
James J M Loan, Ncedile Mankahla, Graeme Meintjes, A Graham Fieggen
BACKGROUND: Hydrocephalus is a recognised complication of human immunodeficiency virus (HIV)-related opportunistic infections. Symptomatic raised cerebrospinal fluid pressure can be treated with ventriculoperitoneal shunt insertion (VPS). In HIV-infected patients however, there is a concern that VPS might be associated with unacceptably high rates of mortality. We aim to systematically review and appraise published literature to determine reported outcomes and identify predictors of outcome following VPS in relevant subgroups of HIV-infected adults...
October 16, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/29029245/host-transcription-profile-in-nasal-epithelium-and-whole-blood-of-hospitalised-children-under-two-years-of-age-with-respiratory-syncytial-virus-infection
#2
Lien Anh Ha Do, Johann Pellet, H Rogier van Doorn, Anh Tuan Tran, Bach Hue Nguyen, Thi Thu Loan Tran, Quynh Huong Tran, Quoc Bao Vo, Nguyen Anh Tran Dac, Hong Nhien Trinh, Thi Thanh Hai Nguyen, Bao Tinh Le Binh, Huu Mai Khanh Nguyen, Minh Tien Nguyen, Quang Tung Thai, Thanh Vu Vo, Ngoc Quang Minh Ngo, Thi Kim Huyen Dang, Ngoc Huong Cao, Thu Van Tran, Lu Viet Ho, Bertrand De Meulder, Charles Auffray, Jorrit-Jan Hofstra, Jeremy Farrar, Juliet E Bryant, Menno de Jong, Martin L Hibberd
Most insights into the cascade of immune events following acute respiratory syncytial virus (RSV) infection have been obtained from animal experiments or in vitro models. Here we investigated host gene expression profiles in nasopharyngeal swabs (NP) and whole blood samples during natural RSV and rhinovirus (hRV) infection (acute versus early recovery phase) in 83 hospitalised patients <2 years old with lower respiratory tract infections (LRTI). RSV infection induced strong and persistent innate immune responses including interferon signaling and pathways related to chemokine/cytokine signaling in both compartments...
September 27, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29020629/differential-regulation-of-lipoprotein-and-hepatitis-c-virus-secretion-by-rab1b
#3
Constantin N Takacs, Ursula Andreo, Viet Loan Dao Thi, Xianfang Wu, Caroline E Gleason, Michelle S Itano, Gabriella S Spitz-Becker, Rachel L Belote, Brenna R Hedin, Margaret A Scull, Charles M Rice, Sanford M Simon
Secretory cells produce diverse cargoes, yet how they regulate concomitant secretory traffic remains insufficiently explored. Rab GTPases control intracellular vesicular transport. To map secretion pathways, we generated a library of lentivirus-expressed dominant-negative Rab mutants and used it in a large-scale screen to identify regulators of hepatic lipoprotein secretion. We identified several candidate pathways, including those mediated by Rab11 and Rab8. Surprisingly, inhibition of Rab1b, the major regulator of transport from the endoplasmic reticulum to the Golgi, differently affected the secretion of the very-low-density lipoprotein components ApoE and ApoB100, despite their final association on mature secreted lipoprotein particles...
October 10, 2017: Cell Reports
https://www.readbyqxmd.com/read/29020329/vitamin-d3-supplementation-increases-spine-bone-mineral-density-in-adolescents-and-young-adults-with-hiv-infection-being-treated-with-tenofovir-disoproxil-fumarate-a-randomized-placebo-controlled-trial
#4
Peter L Havens, Charles B Stephensen, Marta D Van Loan, Gertrud U Schuster, Leslie R Woodhouse, Patricia M Flynn, Catherine M Gordon, Cynthia G Pan, Brandy Rutledge, D Robert Harris, Georgine Price, Alyne Baker, William A Meyer, Craig M Wilson, Rohan Hazra, Bill G Kapogiannis, Kathleen Mulligan
Background: Tenofovir disoproxil fumarate (TDF) decreases bone mineral density (BMD). We hypothesized vitamin D3 (VITD3) would increase BMD in youth receiving TDF. Methods: Randomized double-blind placebo-controlled trial of directly observed VITD3 vs. placebo every 4 weeks for 48 weeks in youth ages 16-24 years with HIV, viral load <200 copies/mL, taking TDF-containing combination antiretroviral therapy (TDF-cART) for ≥180 days. Participants (N=214) received a daily multivitamin containing VITD3 400 IU and calcium 162 mg, plus monthly randomized VITD3 50,000 IU (N=109) or placebo (N=105)...
August 21, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29016401/evaluation-of-the-effectiveness-of-neuromuscular-electrical-stimulation-after-total-knee-arthroplasty-a-meta-analysis
#5
Alessandro Bistolfi, Jessica Zanovello, Riccardo Ferracini, Fabrizio Allisiardi, Elisa Lioce, Ernesta Magistroni, Paola Berchialla, Ilaria Da Rold, Giuseppe Massazza
OBJECTIVE: to evaluate the efficacy of the use of the neuromuscular electrical stimulation (NMES) after total knee arthroplasty (TKA). DESIGN: a systematic review of randomized controlled trials (MEDLINE, PubMed, Cochrane Library, and PEDro) using PICOS approach to formulate the research question, Controlled terms and Boolean operators. Inclusion and exclusion criteria were defined in advance. "Neuromuscular electrical stimulation" and "total knee arthroplasty" were used as keywords...
October 7, 2017: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/28983431/evaluation-of-policy-options-for-increasing-the-availability-of-primary-care-services-in-rural-washington-state
#6
Mark W Friedberg, Grant R Martsolf, Chapin White, David I Auerbach, Ryan Kandrack, Rachel O Reid, Emily Butcher, Hao Yu, Simon Hollands, Xiaoyu Nie
The Washington State legislature has recently considered several policy options to address a perceived shortage of primary care physicians in rural Washington. These policy options include opening the new Elson S. Floyd College of Medicine at Washington State University in 2017; increasing the number of primary care residency positions in the state; expanding educational loan-repayment incentives to encourage primary care physicians to practice in rural Washington; increasing Medicaid payment rates for primary care physicians in rural Washington; and encouraging the adoption of alternative models of primary care, such as medical homes and nurse-managed health centers, that reallocate work from physicians to nurse practitioners (NPs) and physician assistants (PAs)...
January 2017: Rand Health Quarterly
https://www.readbyqxmd.com/read/28972421/third-year-pharmacy-students-propose-an-interprofessional-prediabetes-educational-programme-prediame-prediabetes-me
#7
Chava Chaitin, Jaimie Velasquez, Nile M Khanfar, Stephanie Chassange, Rennie Perez Torres, Ngoc Loan Pham, Martha M Rodriguez, Genevieve M Hale
The American Diabetes Association announced in 2012 that 86 million Americans were diagnosed with prediabetes compared to 79 million in 2010. Prediabetes + Me (PreDiaMe) is an innovative educational programme developed by pharmacy students at Nova Southeastern University College of Pharmacy, which provides collaborative interprofessional care for patients with prediabetes. A literature review using EBSCOhost, EMBASE, and MEDLINE databases searching the terms education, health services, interprofessional team, and prediabetes was conducted...
October 3, 2017: Journal of Interprofessional Care
https://www.readbyqxmd.com/read/28971922/early-medicaid-expansion-associated-with-reduced-payday-borrowing-in-california
#8
Heidi Allen, Ashley Swanson, Jialan Wang, Tal Gross
We examined the impact of California's early Medicaid expansion under the Affordable Care Act on the use of payday loans, a form of high-interest borrowing used by low- and middle-income Americans. Using a data set for the period 2009-13 (roughly twenty-four months before and twenty-four months after the 2011-12 Medicaid expansion) that covered the universe of payday loans from five large payday lenders with locations around the United States, we used a difference-in-differences research design to assess the effect of the expansion on payday borrowing, comparing trends in early-expansion counties in California to those in counties nationwide that did not expand early...
October 1, 2017: Health Affairs
https://www.readbyqxmd.com/read/28966400/into-the-red-and-back-to-the-nest-student-debt-college-completion-and-returning-to-the-parental-home-among-young-adults
#9
Jason N Houle, Cody Warner
Rising student debt has sparked concerns about its impact on the transition to adulthood. In this paper, we examine the claim that student debt is leading to a rise in "boomeranging", or returning home, using data from the National Longitudinal Survey of Youth 1997 Cohort and discrete time event history models. We have four findings. First, student loan debt is not associated with boomeranging in the complete sample. However, we find that the association differs by race, such that the link between student debt and returning home is stronger for black than white youth...
2017: Sociology of Education
https://www.readbyqxmd.com/read/28953295/how-many-graduating-family-medicine-residents-have-chosen-financial-support-for-service-commitments
#10
Julie Phillips, Lars E Peterson, Bo Fang, Iris Kovar-Gough, Robert L Phillips
BACKGROUND AND OBJECTIVES: New family physicians have opportunities to avoid accruing educational debt or have loans repaid by making a commitment to public service. Little information is available about the numbers of early career family physicians who have made service commitments to fund their education. The purpose of this study is to describe the proportion of graduating family medicine residents who have enrolled in US military and National Health Service Corps (NHSC) scholarship and loan repayment programs, thus obligating them to future public service...
September 2017: Family Medicine
https://www.readbyqxmd.com/read/28948025/does-access-to-credit-services-influence-availability-of-essential-child-medicines-and-licensing-status-among-private-medicine-retail-outlets-in-uganda
#11
Lorraine Nabbanja Kabunga, Paschal Mujasi
BACKGROUND: Despite making great progress in reducing under five mortality in the last three decades. Uganda still ranks high among countries with the highest under five mortality rates. More than a third (36%) of these deaths are caused by pneumonia (15%), malaria (12%), or diarrhea (9%). For many mothers and caregivers, private drug shops are a point of care seeking for these illnesses. However, many drug-shops, are unlicensed and do not stock essential commodities due to insufficient capital and operational funds...
2017: Journal of Pharmaceutical Policy and Practice
https://www.readbyqxmd.com/read/28947523/is-the-public-service-loan-forgiveness-program-right-for-you
#12
Vincent Notareschi, Timothy R Ulbrich
No abstract text is available yet for this article.
October 1, 2017: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/28930761/factors-associated-with-medical-school-graduates-intention-to-work-with-underserved-populations-policy-implications-for-advancing-workforce-diversity
#13
Andrea N Garcia, Tony Kuo, Lisa Arangua, Eliseo J Pérez-Stable
PURPOSE: Given projected U.S. physician shortages across all specialties that will likely impact underserved areas disproportionately, the authors sought to explore factors most correlated with medical school graduates' intention to work with underserved populations (IWUP). METHOD: Data from the 2010-2012 Association of American Medical Colleges Medical School Graduation Questionnaire (n = 40,846) were analyzed. Variables (demographics, career preference, debt burden, intention to enter loan forgiveness programs) were examined using chi-square tests and logistic regression models...
September 14, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/28927380/financial-burden-of-survivors-of-medically-managed-myocardial-infarction-and-its-association-with-selected-social-determinants-and-quality-of-life-in-a-lower-middle-income-country
#14
P K B Mahesh, M W Gunathunga, S Jayasinghe, S M Arnold, D S V Mallawarachchi, S K Perera, U A D Wijesinghe
BACKGROUND: Burden from ischemic heart disease is rising in Sri Lanka due to the demographic and epidemiological transitions. Documented literature is scarce on quality of life, financial burden and its determinants in relation to myocardial infarction (MI). This study was done to describe the financial burden among the survivors of MI managed only with drugs (i.e. those who did not undergo Percutaneous Coronary Intervention or Coronary Artery Bypass Graft) and its association with selected social determinants (SDHs) and quality of life (QOL)...
September 19, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28922902/from-directed-donation-to-kidney-sale-does-the-argument-hold-up
#15
James Stacey Taylor
The UCLA Medical Center has initiated a "voucher program" under which a person who donated a kidney would receive a voucher that she could provide to someone of her choosing who could then use it to move to the top of the renal transplantation waiting list. If the use of such vouchers as incentives for donors is morally permissible, then cash payments for kidneys are also morally permissible. But, that argument faces five objections. First, there are some goods whose nature allows them to be exchanged for similar goods but renders them monetarily inalienable...
October 1, 2017: Journal of Medicine and Philosophy
https://www.readbyqxmd.com/read/28917788/glass-polytetrafluoroethylene-glass-based-sandwich-microdevice-for-continuous-flow-polymerase-chain-reaction-and-its-application-for-fast-identification-of-foodborne-pathogens
#16
Kieu The Loan Trinh, Nae Yoon Lee
A uniquely fabricated microdevice with a glass-polytetrafluoroethylene (PTFE)-glass (GPG) sandwich configuration was developed for the fast identification of foodborne pathogens by using continuous-flow polymerase chain reaction (PCR) followed by on-site fluorescence detection of PCR products. A PTFE tube was simply folded into a serpentine configuration and sandwiched between two glass slides to maintain a 2D planar structure. By using a PTFE tube, the microchannel has the advantage of seamlessness without the need for photolithography methods, and is less expensive and less time-consuming to fabricate than alternative devices...
January 1, 2018: Talanta
https://www.readbyqxmd.com/read/28905298/would-environmental-pollution-affect-home-prices-an-empirical-study-based-on-china-s-key-cities
#17
Yu Hao, Shaoqing Zheng
With the development of China's economy, the problem of environmental pollution has become increasingly more serious, affecting the sustained and healthy development of Chinese cities and the willingness of residents to invest in fixed assets. In this paper, a panel data set of 70 of China's key cities from 2003 to 2014 is used to study the effect of environmental pollution on home prices in China's key cities. In addition to the static panel data regression model, this paper uses the generalized method of moments (GMM) to control for the potential endogeneity and introduce the dynamics...
September 13, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28904815/predictors-help-seeking-behaviour-and-treatment-coverage-for-depression-in-adults-in-sehore-district-india
#18
Rahul Shidhaye, Tanica Lyngdoh, Vaibhav Murhar, Sandesh Samudre, Thomas Krafft
BACKGROUND: National Mental Health Survey found that in India, the point prevalence of major depressive disorder (MDD) was 2.7% and the treatment gap was 85.2%, whereas in Madhya Pradesh the point prevalence of MDD was 1.4% and the treatment gap was 80%. AIMS: To describe the baseline prevalence of depression among adults, association of various demographic and socioeconomic variables with depression and estimation of contact coverage for the same. METHOD: Population-based cross-sectional survey of 3220 adults in Sehore district of Madhya Pradesh, India...
September 2017: BJPsych Open
https://www.readbyqxmd.com/read/28899697/implementation-of-a-human-podocyte-injury-model-of-chronic-kidney-disease-for-profiling-of-renoprotective-compounds
#19
Vivek C Abraham, Loan N Miller, Steve D Pratt, Brent Putman, Laura Kim, Sujatha M Gopalakrishnan, Andrew King
Degradation of podocyte structural integrity and function are hallmarks of proteinuric chronic kidney disease. In vivo, injury of podocytes manifests itself in the form of disruption of foot process morphology and associated cytoskeletal architecture, de-differentiation, and loss of adhesion to the glomerular basement membrane. Given the critical role played by this highly specialized cell type in maintaining glomerular filtration, there is a need for improved physiologically relevant cellular models that enable detection of disease-relevant indicators of podocyte perturbation...
September 9, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28889136/electro-navigational-bronchoscopy-for-bilateral-peripheral-lung-lesions-a-case-report
#20
A H Faisal, A W Sopian, H Tidi
Electromagnetic navigational bronchoscopy (ENB), one of the methods of navigational bronchoscopy is an advanced diagnostic tool allowing tissue sampling at the lung peripheries which were previously accessible only by computed tomography (CT) guidance or video-assisted thoracoscopic surgery (VATS). We report a 53-year-old man who presented with a cough and dyspnea with constitutional symptoms for one month. CT thorax revealed multiple bilateral peripheral lung nodules and there were no endobronchial lesions on flexible bronchoscopy...
August 2017: Medical Journal of Malaysia
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