keyword
MENU ▼
Read by QxMD icon Read
search

loan

keyword
https://www.readbyqxmd.com/read/29448507/platinum-nanoparticles-induce-apoptosis-on-raw-264-7-macrophage-cells
#1
Ta Thi Loan, Le Thanh Do, Hoon Yoo
The cellular effects of platinum nanoparticles (PNP05, average size of 5 nm, and PNP30, average size of 30 nm) were investigated on murine leukemia Raw 264.7 cells. Cells treated with various concentrations of PNPs showed size-dependent cytotoxicity in an MTT assay with PNP5 of smaller nanoparticles higher toxicity than PNP30. Investigations on cell morphology, Annexin V assay, DNA fragmentation and the activity of caspase-3/-7 showed that PNPs induced apoptosis on Raw 264.7 cells by changing cell morphology and density, increasing cell population in apoptosis and causing nucleus fragmentation...
February 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29443960/tgf%C3%AE-attenuates-tumour-response-to-pd-l1-blockade-by-contributing-to-exclusion-of-t-cells
#2
Sanjeev Mariathasan, Shannon J Turley, Dorothee Nickles, Alessandra Castiglioni, Kobe Yuen, Yulei Wang, Edward E Kadel Iii, Hartmut Koeppen, Jillian L Astarita, Rafael Cubas, Suchit Jhunjhunwala, Romain Banchereau, Yagai Yang, Yinghui Guan, Cecile Chalouni, James Ziai, Yasin Şenbabaoğlu, Stephen Santoro, Daniel Sheinson, Jeffrey Hung, Jennifer M Giltnane, Andrew A Pierce, Kathryn Mesh, Steve Lianoglou, Johannes Riegler, Richard A D Carano, Pontus Eriksson, Mattias Höglund, Loan Somarriba, Daniel L Halligan, Michiel S van der Heijden, Yohann Loriot, Jonathan E Rosenberg, Lawrence Fong, Ira Mellman, Daniel S Chen, Marjorie Green, Christina Derleth, Gregg D Fine, Priti S Hegde, Richard Bourgon, Thomas Powles
Therapeutic antibodies that block the programmed death-1 (PD-1)-programmed death-ligand 1 (PD-L1) pathway can induce robust and durable responses in patients with various cancers, including metastatic urothelial cancer. However, these responses only occur in a subset of patients. Elucidating the determinants of response and resistance is key to improving outcomes and developing new treatment strategies. Here we examined tumours from a large cohort of patients with metastatic urothelial cancer who were treated with an anti-PD-L1 agent (atezolizumab) and identified major determinants of clinical outcome...
February 14, 2018: Nature
https://www.readbyqxmd.com/read/29423674/intravenous-infusion-of-human-adipose-tissue-derived-mesenchymal-stem-cells-to-treat-type-1-diabetic-mellitus-in-mice-an-evaluation-of-grafted-cell-doses
#3
Loan Thi-Tung Dang, Anh Nguyen-Tu Bui, Cong Le-Thanh Nguyen, Nhat Chau Truong, Anh Thi-Van Bui, Ngoc Phan Kim, Kiet Dinh Truong, Phuc Van Pham
Mesenchymal stem cell (MSC) transplantation is a novel treatment for diabetes mellitus, especially type 1 diabetes. Many recent publications have demonstrated the efficacy of MSC transplantation on reducing blood glucose and increasing insulin production in both preclinical and clinical trials. However, the investigation of grafted cell doses has been lacking. Therefore, this study aimed to evaluate the different doses of MSCs on treatment of type 1 diabetes in mouse models. MSCs were isolated and expanded from human adipose tissue...
February 9, 2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29421977/chronic-alterations-in-systemic-immune-function-after-traumatic-brain-injury
#4
Rodney Ritzel, Sarah Doran, James Barrett, Rebecca Henry, Elise Ma, Alan Faden, David J Loane
There is a compelling link between severe brain trauma and immunosuppression in traumatic brain injury (TBI) patients. Although acute changes in the systemic immune compartment have been linked to outcome severity, the long-term consequences of TBI on systemic immune function is unknown. Here, adult male C57Bl/6 mice were subjected to moderate-level controlled cortical impact (CCI) or sham surgery and systemic immune function was evaluated at 1, 3, 7, 14, and 60 days post-injury. Bone marrow, blood, thymus, and spleen were examined by flow cytometry to assess changes in immune composition, reactive oxygen species (ROS) production, phagocytic activity, and cytokine production...
February 8, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29404525/hepatitis-e-virus-replication-and-interferon-responses-in-human-placental-cells
#5
Leonard Knegendorf, Svenja A Drave, Viet Loan Dao Thi, Yannick Debing, Richard J P Brown, Florian W R Vondran, Kathrin Resner, Martina Friesland, Tanvi Khera, Michael Engelmann, Birgit Bremer, Heiner Wedemeyer, Patrick Behrendt, Johan Neyts, Thomas Pietschmann, Daniel Todt, Eike Steinmann
Hepatitis E virus (HEV) is a member of the genus Orthohepevirus in the family Hepeviridae and the causative agent of hepatitis E in humans. HEV is a major health problem in developing countries, causing mortality rates up to 25% in pregnant women. However, these cases are mainly reported for HEV genotype (gt)1, while gt3 infections are usually associated with subclinical courses of disease. The pathogenic mechanisms of adverse maternal and fetal outcome during pregnancy in HEV-infected pregnant women remain elusive...
February 2018: Hepatology Communications
https://www.readbyqxmd.com/read/29401028/medicaid-expansion-and-payday-loans
#6
Cirila Estela Vasquez Guzman
No abstract text is available yet for this article.
February 2018: Health Affairs
https://www.readbyqxmd.com/read/29399986/2015-rheumatology-workforce-study-the-role-of-graduate-medical-education-in-adult-rheumatology
#7
Marcy B Bolster, Anne R Bass, Jonathan S Hausmann, Chad Deal, Marcia Ditmyer, Kamilah L Greene, Seetha U Monrad, Daniel F Battafarano
OBJECTIVE: Graduate medical education (GME), through fellowship training, plays a critical role in providing new rheumatologists into our workforce and is an essential component when addressing the gap of excess demand for adult rheumatology care. METHODS: Primary and secondary data sources were used to develop an integrated workforce model. Factors specific to new graduates entering the workforce included available and filled fellowship positions, gender shifts, planned work schedules (part-time, full- time), practice settings (academic, non-academic private practice), and number of international medical graduates (IMGs) projecting U...
February 5, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29395325/human-adar1-prevents-endogenous-rna-from-triggering-translational-shutdown
#8
Hachung Chung, Jorg J A Calis, Xianfang Wu, Tony Sun, Yingpu Yu, Stephanie L Sarbanes, Viet Loan Dao Thi, Abigail R Shilvock, H-Heinrich Hoffmann, Brad R Rosenberg, Charles M Rice
Type I interferon (IFN) is produced when host sensors detect foreign nucleic acids, but how sensors differentiate self from nonself nucleic acids, such as double-stranded RNA (dsRNA), is incompletely understood. Mutations in ADAR1, an adenosine-to-inosine editing enzyme of dsRNA, cause Aicardi-Goutières syndrome, an autoinflammatory disorder associated with spontaneous interferon production and neurologic sequelae. We generated ADAR1 knockout human cells to explore ADAR1 substrates and function. ADAR1 primarily edited Alu elements in RNA polymerase II (pol II)-transcribed mRNAs, but not putative pol III-transcribed Alus...
January 12, 2018: Cell
https://www.readbyqxmd.com/read/29384083/combining-optical-coherence-tomography-with-visual-field-data-to-rapidly-detect-disease-progression-in-glaucoma-a-diagnostic-accuracy-study
#9
David F Garway-Heath, Haogang Zhu, Qian Cheng, Katy Morgan, Chris Frost, David P Crabb, Tuan-Anh Ho, Yannis Agiomyrgiannakis
BACKGROUND: Progressive optic nerve damage in glaucoma results in vision loss, quantifiable with visual field (VF) testing. VF measurements are, however, highly variable, making identification of worsening vision ('progression') challenging. Glaucomatous optic nerve damage can also be measured with imaging techniques such as optical coherence tomography (OCT). OBJECTIVE: To compare statistical methods that combine VF and OCT data with VF-only methods to establish whether or not these allow (1) more rapid identification of glaucoma progression and (2) shorter or smaller clinical trials...
January 2018: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/29381170/health-literacy-essential-for-a-culture-of-health
#10
Amy J Barton, Patricia E Allen, Diane K Boyle, Lori A Loan, Jaynelle F Stichler, Terri Ann Parnell
BACKGROUND: A culture of health requires a commitment from all-individuals, families, communities, organizations, and municipalities-to value health and make decisions reflective of a healthy society. At the individual level, health literacy is a necessary precursor to assist individuals in achieving a higher level of health. METHOD: One method for ensuring that staff members are routinely assessing and promoting health literacy is using competencies and practices previously identified for all health professions...
February 1, 2018: Journal of Continuing Education in Nursing
https://www.readbyqxmd.com/read/29377964/ethnical-discrimination-in-europe-field-evidence-from-the-finance-industry
#11
Matthias Stefan, Felix Holzmeister, Alexander Müllauer, Michael Kirchler
The integration of ethnical minorities has been a hotly discussed topic in the political, societal, and economic debate. Persistent discrimination of ethnical minorities can hinder successful integration. Given that unequal access to investment and financing opportunities can cause social and economic disparities due to inferior economic prospects, we conducted a field experiment on ethnical discrimination in the finance sector with 1,218 banks in seven European countries. We contacted banks via e-mail, either with domestic or Arabic sounding names, asking for contact details only...
2018: PloS One
https://www.readbyqxmd.com/read/29363330/chemical-constituents-of-geum-urbanum-l-roots
#12
Quang Ton That, Truong Van Nguyen Thien, Huu Phuc Dang, Ngoc Le Hoan, Loan Kieu Thi Vo, Minh Huu Duc Nguyen, Nhan Truong Ngu, Thien S Nguyen, Poul Erik Hansen
A new dehydrodigallic acid derivative (1), along with 19 known compounds, including 6 phenolic derivatives, 2 steroids and 11 triterpenoids were isolated from the ethanol extract of the root of Geum urbanum. Herein, there is the first report of steroid and triterpene in Geum urbanum. The purified metabolites were characterised by NMR spectroscopic and mass spectrometric analyses. The identification of the known compounds (2-20) was based on the comparison of their NMR spectroscopic features with previously published data...
January 24, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29360889/student-loan-burden-and-its-impact-on-career-decisions-in-dermatology
#13
Jannett Nguyen, Eingun Song, Michael A Liu, Patrick K Lee, Sam Truong
Dermatology departments in the United States face difficulties in recruiting dermatologists to academic positions, raising concerns for the future of dermatology education and research. This preliminary study aimed to explore the impact of student loan burden on career plans in dermatology and to determine if the Public Service Loan Forgiveness (PSLF) program can be used as a recruitment tool for academic positions in dermatology. Results from this electronic survey, which was distributed to dermatology residents and attending physicians, revealed that debt burden may influence career decisions in dermatology...
December 2017: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/29357076/a-grey-dematel-based-approach-for-modeling-enablers-of-green-innovation-in-manufacturing-organizations
#14
Himanshu Gupta, Mukesh Kumar Barua
Incorporating green practices into the manufacturing process has gained momentum over the past few years and is a matter of great concern for both manufacturers as well as researchers. Regulatory pressures in developed countries have forced the organizations to adopt green practices; however, this issue still lacks attention in developing economies like India. There is an urgent need to identify enablers of green innovation for manufacturing organizations and also to identify prominent enablers among those...
January 22, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29355993/relationships-between-army-nursing-practice-environments-and-patient-outcomes
#15
Pauline A Swiger, Lori A Loan, Dheeraj Raju, Sara T Breckenridge-Sproat, Rebecca S Miltner, Patricia A Patrician
Favorable nursing practice environments have been associated with lower patient mortality, failure to rescue, nurse-administered medication errors, infections, patient complaints, and patient falls. Favorable environments have also been associated with higher nurse-reported care quality and patient satisfaction in civilian hospitals. However, limited information exists on the relationship between favorable nursing practice environments and positive outcomes in military facilities. Using 4 years of secondary data collected from 45 units in 10 Army hospitals, generalized estimating equations were used to test the associations between nurses' scores on the Practice Environment Scale of the Nursing Work Index (PES-NWI) and patient outcomes of falls with and without injury, medication administration errors with and without harm, and patient experience...
January 22, 2018: Research in Nursing & Health
https://www.readbyqxmd.com/read/29341431/risk-of-infantile-hemangiomas-in-the-offspring-of-women-with-autoimmune-disease-and-the-pathogenic-implications-of-these-lesions
#16
Chelsey J F Smith, Kenneth L Jones, Diana L Johnson, Gretchen Bandoli, Loan K Robinson, Arthur Kavanaugh, Christina D Chambers
The purpose of this study was to analyze the risk of maternal autoimmune disease or associated treatments on infantile hemangiomas (IHs), a common benign vascular tumor in infants, and to better understand how maternal chronic inflammation may play a factor in the pathogenesis of these lesions. Eligible women from the United States and Canada who enrolled before 19 weeks' gestation and delivered at least one live born infant were recruited as part of the Organization of Teratology Information Specialists (OTIS) Autoimmune Disease in Pregnancy Project from 2004-2013...
January 17, 2018: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/29338431/medically-induced-hypertension-hypervolaemia-and-haemodilution-for-the-treatment-and-prophylaxis-of-vasospasm-following-aneurysmal-subarachnoid-haemorrhage-systematic-review
#17
James J M Loan, Anthony N Wiggins, Paul M Brennan
PURPOSE: Arterial vasospasm is a major cause of death and long-term disability following subarachnoid haemorrhage (SAH). The use of medically induced hypertension, hypervolaemia and/or haemodilution is widely practiced for prophylaxis and treatment of vasospasm following SAH. We aimed to determine if the quality of available research is adequate to inform use of haemodynamic management strategies to prevent or treat vasospasm following SAH. METHODS: Individual searches of the following databases were conducted: The Cochrane Database of Systematic Reviews, The Cochrane Central Register of Controlled Trials, MEDLINE, EMBASE and OpenSIGLE...
January 17, 2018: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/29331444/call-for-action-nurses-must-play-a-critical-role-to-enhance-health-literacy
#18
Lori A Loan, Terri Ann Parnell, Jaynelle F Stichler, Diane K Boyle, Patricia Allen, Christopher A VanFosson, Amy J Barton
No abstract text is available yet for this article.
November 27, 2017: Nursing Outlook
https://www.readbyqxmd.com/read/29313250/adolescents-perceptions-of-the-economy-its-association-with-academic-engagement-and-the-role-of-school-based-and-parental-relationships
#19
Nancy E Hill, Belle Liang, Diamond Y Bravo, Maggi Price, Whitney Polk, John Perella, Mandy Savitz-Romer
In the context of widespread media coverage of economic problems, un- and under-employment, and overwhelming student loan debt, youth are making sense of the prospects of getting a job and value of education. Further, they are assessing the implications of the job market in curtailing or enhancing their future success. School-based and familial relationships may support students in making sense of the job market. The current study focuses on how youth view the economy, its association with academic engagement, and how parental and school-based relationships shape views of the job market and their impact on academic engagement...
January 8, 2018: Journal of Youth and Adolescence
https://www.readbyqxmd.com/read/29313243/racial-and-ethnic-variation-in-the-relationship-between-student-loan-debt-and-the-transition-to-first-birth
#20
Stella Min, Miles G Taylor
The present study employs discrete-time hazard regression models to investigate the relationship between student loan debt and the probability of transitioning to either marital or nonmarital first childbirth using the 1997 National Longitudinal Survey of Youth (NLSY97). Accounting for nonrandom selection into student loans using propensity scores, our study reveals that the effect of student loan debt on the transition to motherhood differs among white, black, and Hispanic women. Hispanic women holding student loans experience significant declines in the probability of transitioning to both marital and nonmarital motherhood, whereas black women with student loans are significantly more likely to transition to any first childbirth...
January 8, 2018: Demography
keyword
keyword
73166
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"