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https://www.readbyqxmd.com/read/29686039/stem-cell-derived-culture-models-of-hepatitis-e-virus-infection
#1
Viet Loan Dao Thi, Xianfang Wu, Charles M Rice
Similar to other hepatotropic viruses, hepatitis E virus (HEV) has been notoriously difficult to propagate in cell culture, limiting studies to unravel its biology. Recently, major advances have been made by passaging primary HEV isolates and selecting variants that replicate efficiently in carcinoma cells. These adaptations, however, can alter HEV biology. We have explored human embryonic or induced pluripotent stem cell (hESC/iPSC)-derived hepatocyte-like cells (HLCs) as an alternative to conventional hepatoma and hepatocyte cell culture systems for HEV studies...
April 23, 2018: Cold Spring Harbor Perspectives in Medicine
https://www.readbyqxmd.com/read/29683751/from-bursaries-to-loans-are-nursing-students-being-turned-into-consumers
#2
Isaac Tuffour
No abstract text is available yet for this article.
April 26, 2018: British Journal of Nursing: BJN
https://www.readbyqxmd.com/read/29670238/traumatic-meningeal-injury-and-repair-mechanisms
#3
David J Loane, Alan I Faden
No abstract text is available yet for this article.
May 2018: Nature Immunology
https://www.readbyqxmd.com/read/29665695/women-in-rural-family-medicine-a-qualitative-exploration-of-practice-attributes-that-promote-physician-satisfaction
#4
Carol Hustedde, Heather Paladine, Andrea Wendling, Rupa Prasad, Orlando Sola, Sarah Bjorkman, Julie Phillips
INTRODUCTION: The USA needs more rural physicians. Although women represent half of all US trained medical students, the rural physician workforce has remained predominantly male. Insight is needed into what makes rural practice attractive for women and which practice characteristics allow women physicians to practice successfully in rural areas. This study's purpose was to examine aspects of the practice environment that impact women physicians' professional satisfaction and commitment to rural medicine...
April 2018: Rural and Remote Health
https://www.readbyqxmd.com/read/29652628/salience-and-impact-of-health-warning-label-on-cigarette-packs-in-vietnam-findings-from-the-global-adult-tobacco-survey-2015
#5
Nguyen Ngoc Bich, Tran Thu Ngan, Kim Bao Giang, Phan Thi Hai, Doan Thi Thu Huyen, Luong Ngoc Khue, Nguyen Tuan Lam, Hoang Van Minh, Pham Thi Quynh Nga, Nguyen The Quan, Vu Hoang Loan
Viet Nam is among the countries having highest rate of male smokers in the world. The country has joined the Global Tobacco Surveillance System since 2010. Under this system, two rounds of Global Adult Tobacco Survey (GATS) were conducted in 2010 and 2015. Those two surveys provide excellent comparable data on tobacco usage and its related aspects in Vietnam. This study using the data from GATS 2015 to examine the salience and impact of cigarette pack health warnings on quitting intention in Vietnam. The Vietnam GATS 2015 was a nationally representative survey in which 9,513 households were selected using two-stage random systematic sampling method...
April 13, 2018: Behavioral Medicine
https://www.readbyqxmd.com/read/29651977/antimicrobial-resistance-in-chlamydiales-rickettsia-coxiella-and-other-intracellular-pathogens
#6
Daisy Vanrompay, Thi Loan Anh Nguyen, Sally J Cutler, Patrick Butaye
This article will provide current insights into antimicrobial susceptibilities and resistance of an important group of bacterial pathogens that are not phylogenetically related but share lifestyle similarities in that they are generally considered to be obligate intracellular microbes. As such, there are shared challenges regarding methods for their detection and subsequent clinical management. Similarly, from the laboratory perspective, susceptibility testing is rarely undertaken, though molecular approaches might provide new insights...
April 2018: Microbiology Spectrum
https://www.readbyqxmd.com/read/29623435/porcine-like-g3p-6-and-g4p-6-rotavirus-a-strains-detected-from-children-with-diarrhoea-in-vietnam
#7
Miho Kaneko, Loan Phuong Do, Yen Hai Doan, Toyoko Nakagomi, Punita Gauchan, Chantal Ama Agbemabiese, Anh Duc Dang, Osamu Nakagomi
Animal rotavirus A (RVA) strains can infect children and cause diarrhoea. We determined the full genome sequences of one G3P[6] strain (NT0001) and five G4P[6] strains (NT0042, NT0077, NT0205, NT0599, and NT0621) detected from children with diarrhoea in Vietnam in 2007-2008. Strain NT0001 had a genotype constellation of: G3-P[6]-I5-R1-C1-M1-A8-N1-T1-E1-H1, strain NT0042: G4-P[6]-I1-R1-C1-M1-A8-N1-T1-E1-H1, strain NT0077: G4-P[6]-I5-R1-C1-M1-A8-N1-T7-E1-H1, and strains NT0205, NT0599, and NT0621: G4-P[6]-I1-R1-C1-M1-A1-N1-T1-E1-H1...
April 5, 2018: Archives of Virology
https://www.readbyqxmd.com/read/29621304/trends-in-congenital-anomalies-in-europe-from-1980-to-2012
#8
Joan K Morris, Anna L Springett, Ruth Greenlees, Maria Loane, Marie-Claude Addor, Larraitz Arriola, Ingeborg Barisic, Jorieke E H Bergman, Melinda Csaky-Szunyogh, Carlos Dias, Elizabeth S Draper, Ester Garne, Miriam Gatt, Babak Khoshnood, Kari Klungsoyr, Catherine Lynch, Robert McDonnell, Vera Nelen, Amanda J Neville, Mary O'Mahony, Anna Pierini, Annette Queisser-Luft, Hanitra Randrianaivo, Judith Rankin, Anke Rissmann, Jennifer Kurinczuk, David Tucker, Christine Verellen-Dumoulin, Diana Wellesley, Helen Dolk
BACKGROUND: Surveillance of congenital anomalies is important to identify potential teratogens. METHODS: This study analysed the prevalence of 61 congenital anomaly subgroups (excluding chromosomal) in 25 population-based EUROCAT registries (1980-2012). Live births, fetal deaths and terminations of pregnancy for fetal anomaly were analysed with multilevel random-effects Poisson regression models. RESULTS: Seventeen anomaly subgroups had statistically significant trends from 2003-2012; 12 increasing and 5 decreasing...
2018: PloS One
https://www.readbyqxmd.com/read/29618611/fam210a-is-a-novel-determinant-of-bone-and-muscle-structure-and-strength
#9
Ken-Ichiro Tanaka, Yingben Xue, Loan Nguyen-Yamamoto, John A Morris, Ippei Kanazawa, Toshitsugu Sugimoto, Simon S Wing, J Brent Richards, David Goltzman
Osteoporosis and sarcopenia are common comorbid diseases, yet their shared mechanisms are largely unknown. We found that genetic variation near FAM210A was associated, through large genome-wide association studies, with fracture, bone mineral density (BMD), and appendicular and whole body lean mass, in humans. In mice, Fam210a was expressed in muscle mitochondria and cytoplasm, as well as in heart and brain, but not in bone. Grip strength and limb lean mass were reduced in tamoxifen-inducible Fam210a homozygous global knockout mice ( TFam210a -/- ), and in tamoxifen-inducible Fam210 skeletal muscle cell-specific knockout mice ( TFam210aMus -/- )...
April 4, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29616079/-stat6-pbx2-and-pbrm1-emerge-as-predicted-regulators-of-452-differentially-expressed-genes-associated-with-puberty-in-brahman-heifers
#10
Loan T Nguyen, Antonio Reverter, Angela Cánovas, Bronwyn Venus, Stephen T Anderson, Alma Islas-Trejo, Marina M Dias, Natalie F Crawford, Sigrid A Lehnert, Juan F Medrano, Milt G Thomas, Stephen S Moore, Marina R S Fortes
The liver plays a central role in metabolism and produces important hormones. Hepatic estrogen receptors and the release of insulin-like growth factor 1 (IGF1) are critical links between liver function and the reproductive system. However, the role of liver in pubertal development is not fully understood. To explore this question, we applied transcriptomic analyses to liver samples of pre- and post-pubertal Brahman heifers and identified differentially expressed (DE) genes and genes encoding transcription factors (TFs)...
2018: Frontiers in Genetics
https://www.readbyqxmd.com/read/29615093/continuous-versus-intermittent-endotracheal-cuff-pressure-control-for-the-prevention-of-ventilator-associated-respiratory-infections-in-vietnam-study-protocol-for-a-randomised-controlled-trial
#11
Vu Quoc Dat, Ronald B Geskus, Marcel Wolbers, Huynh Thi Loan, Lam Minh Yen, Nguyen Thien Binh, Le Thanh Chien, Nguyen Thi Hoang Mai, Nguyen Hoan Phu, Nguyen Phu Huong Lan, Nguyen Van Hao, Hoang Bao Long, Tran Phuong Thuy, Nguyen Van Kinh, Nguyen Vu Trung, Vu Dinh Phu, Nguyen Trung Cap, Dao Tuyet Trinh, James Campbell, Evelyne Kestelyn, Heiman F L Wertheim, Duncan Wyncoll, Guy Edward Thwaites, H Rogier van Doorn, C Louise Thwaites, Behzad Nadjm
BACKGROUND: Ventilator-associated respiratory infection (VARI) comprises ventilator-associated pneumonia (VAP) and ventilator-associated tracheobronchitis (VAT). Although their diagnostic criteria vary, together these are the most common hospital-acquired infections in intensive care units (ICUs) worldwide, responsible for a large proportion of antibiotic use within ICUs. Evidence-based strategies for the prevention of VARI in resource-limited settings are lacking. Preventing the leakage of oropharyngeal secretions into the lung using continuous endotracheal cuff pressure control is a promising strategy...
April 4, 2018: Trials
https://www.readbyqxmd.com/read/29609568/a-cluster-randomized-controlled-trial-to-assess-the-impact-on-intimate-partner-violence-of-a-10-session-participatory-gender-training-curriculum-delivered-to-women-taking-part-in-a-group-based-microfinance-loan-scheme-in-tanzania-maisha-crt01-study-protocol
#12
Sheila Harvey, Shelley Lees, Gerry Mshana, Daniel Pilger, Christian Hansen, Saidi Kapiga, Charlotte Watts
BACKGROUND: Worldwide, almost one third (30%) of women who have been in a relationship have experienced physical and/or sexual violence from an intimate partner. Given the considerable negative impacts of intimate partner violence (IPV) on women's physical health and well-being, there is an urgent need for rigorous evidence on violence prevention interventions. METHODS: The study, comprising a cluster randomized controlled trial (RCT) and in-depth qualitative study, will assess the impact on women's past year experience of physical and/or sexual IPV of a participatory gender training curriculum (MAISHA curriculum) delivered to women participating in group-based microfinance in Tanzania...
April 2, 2018: BMC Women's Health
https://www.readbyqxmd.com/read/29597337/behavioral-intervention-in-adolescents-improves-bone-mass-yet-lactose-maldigestion-is-a-barrier
#13
Yujin Lee, Dennis A Savaiano, George P McCabe, Francis M Pottenger, Kathleen Welshimer, Connie M Weaver, Linda D McCabe, Rachel Novotny, Marsha Read, Scott Going, April Mason, Marta Van Loan, Carol J Boushey
Calcium intake during adolescence is important for attainment of peak bone mass. Lactose maldigestion is an autosomal recessive trait, leading to lower calcium intake. The Adequate Calcium Today study aimed to determine if a school-based targeted behavioral intervention over one year could improve calcium intake and bone mass in early adolescent girls. The school-randomized intervention was conducted at middle schools in six states over one school year. A total of 473 girls aged 10-13 years were recruited for outcome assessments...
March 28, 2018: Nutrients
https://www.readbyqxmd.com/read/29597096/a-sustainable-solution-for-the-activities-of-the-european-network-for-surveillance-of-congenital-anomalies-eurocat-as-part-of-the-eu-platform-on-rare-diseases-registration
#14
REVIEW
Agnieszka Kinsner-Ovaskainen, Monica Lanzoni, Ester Garne, Maria Loane, Joan Morris, Amanda Neville, Ciarán Nicholl, Judith Rankin, Anke Rissmann, David Tucker, Simona Martin
The European Commission through its Directorates-General Joint Research Centre (DG JRC) and Health and Food Safety (DG SANTE) is developing the European Platform on Rare Diseases Registration (EU RD Platform) with the objective to set European-level standards for data collection and data sharing. In the field of rare diseases the EU RD Platform will be a source of information on available rare disease patient data with large transnational European coverage. One main function of the EU RD Platform is to enable interoperability for the >600 existing RD registries in Europe...
March 27, 2018: European Journal of Medical Genetics
https://www.readbyqxmd.com/read/29590131/peer-to-peer-lending-and-bias-in-crowd-decision-making
#15
Pramesh Singh, Jayaram Uparna, Panagiotis Karampourniotis, Emoke-Agnes Horvat, Boleslaw Szymanski, Gyorgy Korniss, Jonathan Z Bakdash, Brian Uzzi
Peer-to-peer lending is hypothesized to help equalize economic opportunities for the world's poor. We empirically investigate the "flat-world" hypothesis, the idea that globalization eventually leads to economic equality, using crowdfinancing data for over 660,000 loans in 220 nations and territories made between 2005 and 2013. Contrary to the flat-world hypothesis, we find that peer-to-peer lending networks are moving away from flatness. Furthermore, decreasing flatness is strongly associated with multiple variables: relatively stable patterns in the difference in the per capita GDP between borrowing and lending nations, ongoing migration flows from borrowing to lending nations worldwide, and the existence of a tie as a historic colonial...
2018: PloS One
https://www.readbyqxmd.com/read/29587777/an-evaluation-of-south-africa-s-public-private-partnership-for-the-localisation-of-vaccine-research-manufacture-and-distribution
#16
David R Walwyn, Adolph T Nkolele
BACKGROUND: Public-private partnerships (PPPs), widely used as a means of leveraging the skills, expertise and resources of the private sector to mutual advantage, were similarly adopted by South Africa to support public sector delivery. This study has evaluated one such partnership, namely the Biovac Institute, which was established in 2003 to cover vaccine research and development, manufacturing, and supply. The initiative was highly unusual given that it attempted to combine all three aspects in a single PPP...
March 27, 2018: Health Research Policy and Systems
https://www.readbyqxmd.com/read/29553451/job-satisfaction-and-mental-health-of-palestinian-nurses-with-shift-work-a-cross-sectional-study
#17
Yousef Jaradat, Morten Birkeland Nielsen, Petter Kristensen, Rita Bast-Pettersen
BACKGROUND: Shift work is associated with sleep disturbances, mental health problems, and job dissatisfaction. Disparities between male and female nurses in the effect of shift work on mental distress and job satisfaction have been scarcely studied. We aimed to examine differences between female and male nurses in the associations between shift work and job satisfaction and mental health. METHODS: In this cross-sectional study, male and female nurses were recruited to rate their job satisfaction on the Generic Job Satisfaction Scale and to complete the General Health Questionnaire (GHQ-30)...
February 21, 2018: Lancet
https://www.readbyqxmd.com/read/29537478/characteristics-of-graduating-family-medicine-residents-who-intend-to-practice-maternity-care
#18
Sebastian T Tong, Camille J Hochheimer, Wendy B Barr, Matteo Leveroni-Calvi, Nicholas M Lefevre, Jordyn T Wallenborn, Lars E Peterson
BACKGROUND AND OBJECTIVES: Prior research found that 24% of graduating family medicine residents intend to provide obstetrical deliveries, but only 9% of family physicians 1 to 10 years into practice are doing so. Our study aims to describe the individual and residency program characteristics associated with intention to provide obstetrical deliveries and prenatal care. METHODS: Cross-sectional data on 2014-2016 graduating residents were obtained from the American Board of Family Medicine certification examination demographic questionnaire that asked about intended provision of specific clinical activities...
March 8, 2018: Family Medicine
https://www.readbyqxmd.com/read/29533307/does-continuous-video-eeg-in-patients-with-altered-consciousness-improve-patient-outcome-current-evidence-and-randomized-controlled-trial-design
#19
Andrea O Rossetti, Kaspar Schindler, Vincent Alvarez, Raoul Sutter, Jan Novy, Mauro Oddo, Loane Warpelin-Decrausaz, Stephan Rüegg
Continuous video-EEG is recommended for patients with altered consciousness; as compared to routine EEG (lasting <30 minutes), it improves seizure detection, but is time- and resource-consuming. Although North American centers increasingly implement continuous video-EEG, most other (including European) hospitals have insufficient resources. Only one study suggested that continuous video-EEG could improve outcome in adults, and a recent assessments challenge this view. This article reviews current evidence on the added value for continuous video-EEG in clinical terms and describes a design for a prospective study...
March 8, 2018: Journal of Clinical Neurophysiology: Official Publication of the American Electroencephalographic Society
https://www.readbyqxmd.com/read/29522185/maximizing-home-equity-or-preventing-home-loss-reverse-mortgage-decision-making-and-racial-inequality
#20
Danya E Keene, Ann Sarnak, Caitlin Coyle
Background and Objectives: Reverse mortgages are loans that allow older homeowners to borrow from their home equity with no repayment due until the borrower dies or moves out of the home. We currently know very little about how homeowners evaluate and experience reverse mortgages as solutions to their financial and housing needs in later life. Furthermore, despite an increasingly diverse population of reverse mortgage borrowers, we know little about how social inequalities may contribute to reverse mortgage decisions and their outcomes...
March 7, 2018: Gerontologist
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